TPOR Rabbit Recombinant mAb Datasheet

生物描述

特异性	TPOR Rabbit Recombinant mAb detects endogenous level of total TPOR.
背景	The cytokine thrombopoietin (TPO) is the chief regulator of megakaryocyte (MK) and platelet production, signaling via its receptor, MPL (TPO-R). TPO-R is 635 amino acids in length and has three functional domains: an extracellular portion involved in cytokine binding, a transmembrane domain (TMD), and a cytoplasmic domain, likely largely unstructured, which binds JAKs and other signaling molecules, such as STATs. TPO-R is expressed predominantly on the surface of MKs, platelets, hemangioblasts, and hematopoietic stem cells (HSCs). It has no intrinsic kinase activity and utilizes the Janus kinase (JAK) family of proteins to transduce signal from the extracellular cytokine to the nucleus within the cell.

特异性

TPOR Rabbit Recombinant mAb detects endogenous level of total TPOR.

背景

The cytokine thrombopoietin (TPO) is the chief regulator of megakaryocyte (MK) and platelet production, signaling via its receptor, MPL (TPO-R). TPO-R is 635 amino acids in length and has three functional domains: an extracellular portion involved in cytokine binding, a transmembrane domain (TMD), and a cytoplasmic domain, likely largely unstructured, which binds JAKs and other signaling molecules, such as STATs. TPO-R is expressed predominantly on the surface of MKs, platelets, hemangioblasts, and hematopoietic stem cells (HSCs). It has no intrinsic kinase activity and utilizes the Janus kinase (JAK) family of proteins to transduce signal from the extracellular cytokine to the nucleus within the cell.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

82kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Leila N. Varghese, et al. Front Endocrinol (Lausanne). 2017, 8: 59.

Application Data

WB

Validated by Selleck