TRAF2 Rabbit Recombinant mAb Datasheet

生物描述

特异性	TRAF2 Rabbit Recombinant mAb detects endogenous level of total TRAF2.
背景	TNF receptor-associated factor 2 (TRAF2) is a member of TRAF family of proteins. It is an important signal transducer for a wide range of TNF receptor superfamily members, in cluding TNFR1, TNFR2, CD40 and other lymphocyte costimulatory receptors, RANK/TRANCE-R, EDAR, LTβR, LMP-1 and IRE1. Therefore, it regulate diverse physiological roles, ranging from T and B cell signaling and inflammatory responses to organogenesis and cell survival. TRAF2 is heavily regulated by ubiquitin signals, and many of the signaling functions of TRAF2 are mediated through its RING domain and likely its own role as an E3 ubiquitin ligase. TRAF2 recruits cIAPs to the TNFα-TNFR1 signaling complex, facilitating NF-κB activation. TRAF2 also supports K48-linked ubiquitination and proteasomal degradation of death-receptor-activated caspase-8, curbing apoptosis. It is a necroptosis suppressor in vitro and in vivo.

特异性

TRAF2 Rabbit Recombinant mAb detects endogenous level of total TRAF2.

背景

TNF receptor-associated factor 2 (TRAF2) is a member of TRAF family of proteins. It is an important signal transducer for a wide range of TNF receptor superfamily members, in cluding TNFR1, TNFR2, CD40 and other lymphocyte costimulatory receptors, RANK/TRANCE-R, EDAR, LTβR, LMP-1 and IRE1. Therefore, it regulate diverse physiological roles, ranging from T and B cell signaling and inflammatory responses to organogenesis and cell survival. TRAF2 is heavily regulated by ubiquitin signals, and many of the signaling functions of TRAF2 are mediated through its RING domain and likely its own role as an E3 ubiquitin ligase. TRAF2 recruits cIAPs to the TNFα-TNFR1 signaling complex, facilitating NF-κB activation. TRAF2 also supports K48-linked ubiquitination and proteasomal degradation of death-receptor-activated caspase-8, curbing apoptosis. It is a necroptosis suppressor in vitro and in vivo.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

56kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck