Datasheet

生物描述

特异性	TXNIP Rabbit Recombinant mAb detects endogenous levels of total TXNIP
背景	Thioredoxin-interacting protein (Txnip), formerly known as VDUP1 or TBP-2, interacts with thioredoxin at its active-site thiols. Txnip plays important roles in diverse physiological or pathological processes. In many cancer cell lines or cancer tissues, the expression of the Txnip gene is down-regulated because Txnip can inhibit cell proliferation and promote apoptosis, it is thought that low Txnip expression may contribute to cancer development. Txnip is also identified as a negative regulator for cellular glucose uptake and Txnip knock-out mice exhibit abnormalities in glucose and lipid metabolism.

特异性

TXNIP Rabbit Recombinant mAb detects endogenous levels of total TXNIP

背景

Thioredoxin-interacting protein (Txnip), formerly known as VDUP1 or TBP-2, interacts with thioredoxin at its active-site thiols. Txnip plays important roles in diverse physiological or pathological processes. In many cancer cell lines or cancer tissues, the expression of the Txnip gene is down-regulated because Txnip can inhibit cell proliferation and promote apoptosis, it is thought that low Txnip expression may contribute to cancer development. Txnip is also identified as a negative regulator for cellular glucose uptake and Txnip knock-out mice exhibit abnormalities in glucose and lipid metabolism.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

53kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck