USP28 Rabbit Recombinant mAb

目录号：A5582

生物描述

特异性	USP28 Rabbit Recombinant mAb detects endogenous level of total USP28.
背景	USP28 is an ubiquitin-specific protease. Members of this class of enzymes can enhance the stability of individual proteins by antagonizing the activity of ubiquitin E3 ligases. They are regulators of oncogenes and tumor suppressors. Usp28 controls MYC stability through antagonistic effects on the activity of the SCF-Fbxw7 ubiquitin ligase complex, and that the stabilization of MYC by Usp28 is required for proliferation of several tumor cell types and for inhibition of cell differentiation in colon carcinoma.

特异性

USP28 Rabbit Recombinant mAb detects endogenous level of total USP28.

背景

USP28 is an ubiquitin-specific protease. Members of this class of enzymes can enhance the stability of individual proteins by antagonizing the activity of ubiquitin E3 ligases. They are regulators of oncogenes and tumor suppressors. Usp28 controls MYC stability through antagonistic effects on the activity of the SCF-Fbxw7 ubiquitin ligase complex, and that the stabilization of MYC by Usp28 is required for proliferation of several tumor cell types and for inhibition of cell differentiation in colon carcinoma.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

1:1000

反应性

Human

MW (kDa)

135kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Popov N, et al. Nat Cell Biol. 2007, 9(7):765-74.
[2] Guo G, et al. Tumour Biol. 2014, 35(5):4017-22.

Application Data

Validated by Selleck