USP14 Rabbit Recombinant mAb

生物描述

特异性

USP14 Rabbit Recombinant mAb detects endogenous level of total USP14.

背景

The ubiquitin-specific protease 14 (USP14) is one of the most extensively studied deubiquitinating enzymes of the proteasome complex. USP14 negatively regulates proteasome activity by ubiquitin chain disassembly as well as by a noncatalytic mechanism. It localized both pre- and postsynapticallya and associated with the 19S regulatory particle of the proteasome; USP14 inhibits proteasome-mediated degradation of substrates by trimming ubiquitin chains and maintains cellular levels of free ubiquitin. It negatively regulates surface levels of GABA receptors in Purkinje neurons.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human Mouse Rat
MW (kDa)	56kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Jarome TJ, et al. Learn Mem. 2013, 21(1):9-13. [2] Lee BH, et al. Nature. 2016, 532(7599):398-401. [3] Jennifer R. Kowalski, et al. Neural Plasticity. 2012.

Application Data

WB

IHC

IF