VAV2 Rabbit Recombinant mAb

生物描述

特异性

VAV2 Rabbit Recombinant mAb detects endogenous level of total VAV2.

背景

Vav proteins are guanine nucleotide exchange factors for Rho GTPases that regulate cell adhesion, motility, spreading and proliferation in response to growth factor signalling. Vav1, the best characterized of the three human Vav family members, is expressed in hematopoietic cells and their derivatives whereas the other two proteins, Vav2 and Vav3, show wider expression patterns. Vav proteins are potent oncogenes that can induce cell transformation by activating Rho GTPase function and modulating cell signaling. Vav2 Demonstrates GEF exchange activity on RhoA, Rac1, and Cdc42 in vitro. Vav2 and EGFR localize to the same regions at the cell membrane and share interactions with several proteins including Src kinases family, Ras, Cbl and Grb2. Vav2 expression delayed epidermal growth factor receptor (EGFR) internalization and degradation, and enhanced EGFR, ERK and Akt phosphorylations.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	101kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] S Thalappilly, et al. Oncogene. 2010, 29: 2528-2539. [2] Abe Km, et al. J Biol Chem. 2000, 275(14):10141-9.

Application Data

WB

IHC