生物描述

特异性

VCP Rabbit Recombinant mAb detects endogenous levels of total VCP.

背景

Valosin-containing protein (VCP, also called p97 in mammals, Cdc48 in yeast, CDC-48 in Caenorhabditis elegans, and Ter94 in Drosophila melanogaster) is a hexameric protein belonging to the type II AAA+ (ATPases associated with diverse cellular activities) protein family. VCP is closely associated with UPS-mediated protein degradation in endoplasmic reticulum-associated protein degradation (ERAD) and mitochondrial protein degradation. VCP also regulates cellular homeostasis and survival through positive or negative modulation of apoptosis and autophagy. VCP is found in the brain, skeletal muscle, ovary, testis, kidney, liver, heart, lung, lymph nodes, and whole blood. The intracellular location of VPC is mostly in the cytosol and nucleus. It is also present in the Golgi apparatus, ER, and mitochondria, which is likely related to its multiple cellular functions.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	89kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] BK Yeo, et al. Animal cells and systems. 2016, 20:303-309.

Application Data

WB

IHC