Tezacaftor (VX-661)

目录号：S7059 批次号：S705902

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₆H₂₇F₃N₂O₆
	分子量	520.5	CAS号	1152311-62-0
Solubility (25°C)*	体外	DMSO	100 mg/mL (192.12 mM)
		Ethanol	100 mg/mL (192.12 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Tezacaftor (VX-661)是第二个F508del CFTR校正药物，协助CFTR蛋白到达细胞表面。Phase 2。

靶点

F508del-CFTR ^[1]
(Cell-free assay)

体外研究

VX-661是CFTR校正药物，使F508del突变通道避免降解且转运到细胞膜上。

参考文献

客户使用selleck产品的实验数据

: 数据来源于[Data independently produced by Sci Transl Med, 2014, 6(246), 246ra96]

: 数据来源于[Data independently produced by , , J Cyst Fibros, 2018, doi:10.1016/j.jcf.2018.07.001]

: 数据来源于[Data independently produced by , , NPJ Genom Med. 2017, 2:12]

Tezacaftor (VX-661)在文献中得到引用

PTI-801 (posenacaftor) shares a common mechanism with VX-445 (elexacaftor) to rescue p.Phe508del-CFTR [ Eur J Pharmacol, 2024, 967:176390]	PubMed: 38336013
CFTR function is impaired in a subset of patients with pancreatitis carrying rare CFTR variants [ Pancreatology, 2024, S1424-3903(24)00066-8]	PubMed: 38493004
A uniquely efficacious type of CFTR corrector with complementary mode of action [ Sci Adv, 2024, 10(9):eadk1814]	PubMed: 38427726
UBE3C Facilitates the ER-Associated and Peripheral Degradation of Misfolded CFTR [ Cells, 2023, 12(23)2741]	PubMed: 38067172
A Novel Co-Culture Model Reveals Enhanced CFTR Rescue in Primary Cystic Fibrosis Airway Epithelial Cultures with Persistent Pseudomonas aeruginosa Infection [ Cells, 2023, 10.3390/cells12222618]	PubMed: 37998353
Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium [ Front Pharmacol, 2023, 14:1293578]	PubMed: 38149052
Elexacaftor Mediates the Rescue of F508del CFTR Functional Expression Interacting with MSD2 [ Int J Mol Sci, 2023, 24(16)12838]	PubMed: 37629017
Theratyping of the Rare CFTR Genotype A559T in Rectal Organoids and Nasal Cells Reveals a Relevant Response to Elexacaftor (VX-445) and Tezacaftor (VX-661) Combination [ Int J Mol Sci, 2023, 24(12)10358]	PubMed: 37373505
CFTR Function Restoration upon Elexacaftor/Tezacaftor/Ivacaftor Treatment in Patient-Derived Intestinal Organoids with Rare CFTR Genotypes [ Int J Mol Sci, 2023, 24(19)14539]	PubMed: 37833986
Rescue of Rare CFTR Trafficking Mutants Highlights a Structural Location-Dependent Pattern for Correction [ Int J Mol Sci, 2023, 24(4)3211]	PubMed: 36834620

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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