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特异性 | WDR5 Rabbit Recombinant mAb detects endogenous level of total WDR5. |
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背景 | WDR5 is a highly conserved WD40 repeat-containing protein that is essential for proper regulation of multiple cellular processes. It is a core scaffolding component of histone H3 lysine 4 methyltransferases. It is a fascinating example of a protein that sits squarely at the crossroads of development, epigenetic control, transcription, and cell division. Its multitude of interactions, with both proteins and RNAs, endows it with a broad range of molecular functions, and it appears to manage the volume of traffic at its surface by creative reuse of two main binding sites. WDR5 has emerged as a prime target for anti-cancer drug discovery efforts, which have already been shown to selectively inhibit cancer cells carrying specific genetic lesions. |
抗体应用 | WB,ELISA,ELISA | ||
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稀释比例 |
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反应性 | Human Mouse Rat | ||
MW (kDa) | 36kDa | ||
抗体类型 | Rabbit | ||
储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
储存条件 (自收到货起) |
Store at –20°C. |
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WB
Validated by Selleck