Nrf2

  • 抑制剂选择性比较
  • 溶解性比较
目录号 产品目录 溶解度(25°C)
DMSO 酒精
S1848 Curcumin <1 mg/mL 73 mg/mL <1 mg/mL
S7864 Oltipraz <1 mg/mL 39 mg/mL <1 mg/mL
S3784 Obacunone -1 mg/mL 90 mg/mL -1 mg/mL
S4990 TBHQ -1 mg/mL 33 mg/mL -1 mg/mL
产品目录 产品描述 文献引用 实验数据
S1848

Curcumin

Curcumin 是流行的印度香料姜黄的主要姜黄色素,属于姜科(Zingiberaceae)。它是p300 histone acetylatransferase(IC50~25 μM)和Histone deacetylase的抑制剂,能够激活Nrf2 pathway并抑制NF-κB的激活。

S7864

Oltipraz

Oltipraz 是一种有效的 Nrf2 激活剂,也是一种有效的II期解毒酶诱导剂,显著作用于谷胱甘肽-S-转移酶(GST)。Phase 3。

S3784New

Obacunone

Obacunone, a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.

S4990New

TBHQ

Tert-butylhydroquinone (TBHQ)是一种抗氧化剂,用于阻止脂质过氧化,具有多种细胞保护作用。同时,它也是Nrf2的激活剂。

S4712

Diethylmaleate

Diethylmaleate是Nrf2的激活剂,是马来酸的二乙酯形式,能消耗谷胱甘肽并抑制NFkB。