Ponatinib (AP24534)

目录号:S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。

规格 价格 库存 购买数量  
RMB 819.31 现货
RMB 903.01 现货
RMB 3034.48 现货
RMB 7959.08 现货
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客户使用该产品的4个实验数据:

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017. Ponatinib (AP24534) purchased from Selleck.

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。
靶点
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外研究

Ponatinib是有效的可用于口服的多靶点激酶抑制剂,作用于野生型细胞,及T315I 突变细胞IC50分别为1.2和8.8nM。[1] Ponatinib抑制Ba/F3衍生细胞系的增殖。[2] Ponatinib作用于表达野生型或T315I突变型BCR-ABL的CML细胞系,有效抑制BCR-ABL调节的信号。Ponatinib阻断在细胞瘤筛选时产生抗性突变。[3] Ponatinib也抑制VEGFR和FGFR家族激酶,在体外抑制FLT3, KIT, FGFR1,和PDGFRa激酶活性时IC50分别为13, 13, 2, 和1 nM.[4]Ponatinib抑制全部4种RTKs磷酸化,存在剂量依赖性,IC50值为0.3到20 nM。然而,Ponatinib抑制表达野生型FLT3的RS4;11细胞时IC50>100 nM。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;2XWlEPTB;MD6wNFAxODByM{W5JO69VQ>? NXTncpF3W0GQR1XS
MV-4-11 NYrGNnV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMECwNFk2PiEQvF2= MnPEV2FPT0WU
MEG-01 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMECwNVI5KM7:TR?= MlvqV2FPT0WU
LAMA-84 NXzmbFk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMECwNVY2KM7:TR?= NHnzWYxUSU6JRWK=
CGTH-W-1 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP5fZJLUUN3ME2wMlAxOTZ7IN88US=> MkXFV2FPT0WU
KASUMI-1 MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHDWIpKSzVyPUCuNFAzOTdizszN M1[2SnNCVkeHUh?=
BE-13 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMECyOVkh|ryP M1LmN3NCVkeHUh?=
CTV-1 NHzIVYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTJTWM2OD1yLkCwOVIyKM7:TR?= NX7nb4FtW0GQR1XS
NKM-1 M4rDeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIflPZlKSzVyPUCuNFA3PTVizszN MXTTRW5ITVJ?
MONO-MAC-6 MlL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\EO|BKSzVyPUCuNFA5OzdizszN MXvTRW5ITVJ?
A204 MoL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7NZ4EyUUN3ME2wMlAyOjF6IN88US=> NWW3eIFIW0GQR1XS
GDM-1 NFe5PJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn2TWM2OD1yLkCxPFM{KM7:TR?= MmK2V2FPT0WU
AN3-CA NHrlZoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnvNJJIUUN3ME2wMlAyQDd|IN88US=> MV7TRW5ITVJ?
BL-70 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTBPG5HUUN3ME2wMlAzOTl7IN88US=> MVvTRW5ITVJ?
Daudi M3jT[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHp[VBKSzVyPUCuNFI2OzdizszN MlL1V2FPT0WU
KU812 M4HiV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;LNWZ6UUN3ME2wMlAzQDR6IN88US=> NXqzOpBKW0GQR1XS
KG-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jESWlEPTB;MD6wN|I6PCEQvF2= NWDDPYdVW0GQR1XS
DOHH-2 M1\OXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3O1VmlEPTB;MD6wOFgxOyEQvF2= MXrTRW5ITVJ?
HuO9 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzJSJJGUUN3ME2wMlA2PDR6IN88US=> NWfPPWRZW0GQR1XS
EB2 NITYOohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMEW1O|Yh|ryP MlXLV2FPT0WU
G-402 M4rpW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXX2NZZiUUN3ME2wMlA3OzRzIN88US=> NHXCUFlUSU6JRWK=
SU-DHL-1 M{\IfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4exdGlEPTB;MD6wOlM4QSEQvF2= M3PI[nNCVkeHUh?=
NCI-H719 NV20OIZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEe4PFgh|ryP M2j2fXNCVkeHUh?=
MLMA MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEmwOkDPxE1? MWjTRW5ITVJ?
KM12 MkjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHBZZJEUUN3ME2wMlA6PzN5IN88US=> MVXTRW5ITVJ?
SUP-T1 M1zKXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUS4b4NHUUN3ME2wMlA6QTh{IN88US=> M3jKVnNCVkeHUh?=
MZ1-PC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrpTVNFUUN3ME2wMlEyOzN4IN88US=> NIqzUFVUSU6JRWK=
MFE-296 NXHncItRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMUG4N|kh|ryP NY\UWFAyW0GQR1XS
ALL-PO MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzFTWM2OD1yLkGyOFQ{KM7:TR?= MnPZV2FPT0WU
GB-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jTWmlEPTB;MD6xNlUyOiEQvF2= Mk\wV2FPT0WU
SIG-M5 NGHoOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HuRmlEPTB;MD6xN|M4KM7:TR?= NV;RVm1XW0GQR1XS
P30-OHK MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHpTWM2OD1yLkG1OlczKM7:TR?= NXLFXFBPW0GQR1XS
NCI-H716 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMU[yOlYh|ryP NITVdo1USU6JRWK=
MPP-89 M{XkZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\oOGJ5UUN3ME2wMlE3QTN|IN88US=> NWrnRYI3W0GQR1XS
SF126 NGT4U|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfVVZBKSzVyPUCuNVcxPjNizszN MY\TRW5ITVJ?
CTB-1 NH3V[pFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMUezNVYh|ryP MVHTRW5ITVJ?
CA46 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjJOFhxUUN3ME2wMlE4PDh7IN88US=> NF\PfHNUSU6JRWK=
NCI-H520 NXTN[pFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjHPGZKSzVyPUCuNVc4OzJizszN MVrTRW5ITVJ?
CAL-85-1 NXHTZm9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMUe5Nlch|ryP NES2V41USU6JRWK=
NCI-H2342 NHLhbXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTReWNKSzVyPUCuNVg2PzdizszN MlTOV2FPT0WU
697 NGjmU|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTqTWM2OD1yLkG4PFcyKM7:TR?= M1zvOXNCVkeHUh?=
NY Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMUmyPFch|ryP MY\TRW5ITVJ?
T98G M3nvNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnzbotKSzVyPUCuNVk{OThizszN M2ns[nNCVkeHUh?=
NCI-H1703 NF7yZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMUm2NVUh|ryP NIK0OJpUSU6JRWK=
NCI-H2087 MmfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMkC0N|kh|ryP NXXucWZCW0GQR1XS
PF-382 MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMkC4O|Mh|ryP MmrBV2FPT0WU
HCT-116 NUXYSmpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\QfmlEPTB;MD6yNVA3QSEQvF2= MoD5V2FPT0WU
CAKI-1 Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{CyNGlEPTB;MD6yNVY3PiEQvF2= NHSzW3hUSU6JRWK=
CCF-STTG1 NHTEO3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmWwTWM2OD1yLkKyOFc2KM7:TR?= NUHlZnhEW0GQR1XS
D-392MG NID4blVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfETolHUUN3ME2wMlI{OTd5IN88US=> NUm1RYxpW0GQR1XS
RT-112 NIf0fHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFG5[2FKSzVyPUCuNlM4QTVizszN NXuyUFh3W0GQR1XS
MES-SA MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PSZmlEPTB;MD6yOFE5PyEQvF2= M1rXS3NCVkeHUh?=
LC-2-ad NH\vWYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4D3fWlEPTB;MD6yOFI3PSEQvF2= MYPTRW5ITVJ?
NOS-1 MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz1TWM2OD1yLkK0N|Y4KM7:TR?= NGqyfXBUSU6JRWK=
NALM-6 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS1TWM2OD1yLkK1OVQ{KM7:TR?= MXjTRW5ITVJ?
TE-15 MoPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\ETWM2OD1yLkK2NFkyKM7:TR?= NIK2SIhUSU6JRWK=
786-0 NWHQVHhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYW4dJI4UUN3ME2wMlI3OjJ6IN88US=> Mn;YV2FPT0WU
IST-MES1 M2HUd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7CTWM2OD1yLkK2PFI6KM7:TR?= NYrrNGlxW0GQR1XS
KYSE-180 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXQSnVKSzVyPUCuNlY5QTFizszN NEW3U5pUSU6JRWK=
YT MojDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37wdGlEPTB;MD6yOlk4PCEQvF2= NU\2WWlZW0GQR1XS
A427 MlPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfCTWM2OD1yLkK3NlY1KM7:TR?= NXvyWItnW0GQR1XS
KYSE-450 MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\WcGZzUUN3ME2wMlI4OzJ7IN88US=> M1;DRnNCVkeHUh?=
HuH-7 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInCeGVKSzVyPUCuNlc4PjNizszN MlGxV2FPT0WU
CAS-1 NFv5WmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMkizNFMh|ryP NW\aSYRjW0GQR1XS
KURAMOCHI MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TOcmlEPTB;MD6yPFQyQSEQvF2= NIHn[INUSU6JRWK=
ACHN MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPrd5pKSzVyPUCuNlk{OjNizszN MUXTRW5ITVJ?
HGC-27 NV\qOFNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;aXWJKSzVyPUCuNlk{PTNizszN M4rIXnNCVkeHUh?=
A172 NXjRNmVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLFb5NKSzVyPUCuNlk2PzdizszN MWrTRW5ITVJ?
SNU-449 NVrqNllmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMkm5OlQh|ryP NGnSbmZUSU6JRWK=
SW982 NXPBVItbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMkm5O|gh|ryP M13xZnNCVkeHUh?=
EFO-21 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofyTWM2OD1yLkOwOFEyKM7:TR?= MorDV2FPT0WU
NCI-H2030 NYjHcXpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nJfWlEPTB;MD6zNVE3PCEQvF2= NFXvcHpUSU6JRWK=
HT-144 MlzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwM{GyPEDPxE1? NWryTGo4W0GQR1XS
MFE-280 NUfhPFQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7yWJJuUUN3ME2wMlMyPDV|IN88US=> NGTaW3NUSU6JRWK=
SK-LU-1 NYiwT2l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn62TWM2OD1yLkOxOFY3KM7:TR?= M2rVcXNCVkeHUh?=
NCI-H2052 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXxc|NHUUN3ME2wMlMyPDh2IN88US=> NXHiWIJrW0GQR1XS
SK-HEP-1 NF3SVWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwM{OzOlgh|ryP Mlu2V2FPT0WU
QIMR-WIL NEjBUItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwM{O0NlQh|ryP NH:xXVBUSU6JRWK=
A2780 MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon3TWM2OD1yLkO0N|A1KM7:TR?= MUTTRW5ITVJ?
ACN M4TWbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnpV|hkUUN3ME2wMlM1QDd|IN88US=> NWfWVIl6W0GQR1XS
BxPC-3 NY\EcZR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nQfWlEPTB;MD6zOFk5QSEQvF2= NXq2R5FDW0GQR1XS
BCPAP M4THW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jZbWlEPTB;MD6zOlAxOSEQvF2= MlzmV2FPT0WU
HOP-62 NIXYS2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnINHdpUUN3ME2wMlM3OTB4IN88US=> NGjWS2xUSU6JRWK=
SW1710 NUS5dXFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwM{[0OVUh|ryP NYHlTZJPW0GQR1XS
OPM-2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PIdGlEPTB;MD6zOlQ4OyEQvF2= M1;RcHNCVkeHUh?=
DBTRG-05MG MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHIc2VDUUN3ME2wMlM5ODV2IN88US=> NELDb3FUSU6JRWK=
SK-MEL-24 M4ntcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwM{m3PVEh|ryP M{HU[HNCVkeHUh?=
8305C M33uemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD3TWM2OD1yLkO5O|k{KM7:TR?= MVXTRW5ITVJ?
OVCAR-4 M1vUcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe1WJFwUUN3ME2wMlQyPTh4IN88US=> NFGzT4NUSU6JRWK=
HLE MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHFeIZKSzVyPUCuOFE5PiEQvF2= M{G3U3NCVkeHUh?=
NCI-H747 M1;RSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorTTWM2OD1yLkSyNVM4KM7:TR?= MXPTRW5ITVJ?
SW780 M2nDXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnQWmNKSzVyPUCuOFI{PDZizszN NH\jVlVUSU6JRWK=
KYSE-150 M1\mVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7FVHZ[UUN3ME2wMlQzPDF3IN88US=> NUDKSpBNW0GQR1XS
H4 M3vDfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHaXnJIUUN3ME2wMlQzPDVzIN88US=> MV\TRW5ITVJ?
SW1088 NHfyeXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnYUpZTUUN3ME2wMlQ1OzlizszN NX;qdmc5W0GQR1XS
SF268 MlTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PFOGlEPTB;MD60OFg3KM7:TR?= NGPYbYtUSU6JRWK=
RT4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTOTWM2OD1yLkS1NVEyKM7:TR?= NXq2OWQ3W0GQR1XS
NCI-H522 MmSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwNEWyO{DPxE1? M4nWXnNCVkeHUh?=
LCLC-97TM1 MnrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1OzeWlEPTB;MD60OlE6PSEQvF2= M{HCXHNCVkeHUh?=
CAL-39 NWXzRppIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXKPZprUUN3ME2wMlQ3PTF7IN88US=> NEjUUFBUSU6JRWK=
CAL-120 MkLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnq0TWM2OD1yLkS3OlQ{KM7:TR?= M1jVV3NCVkeHUh?=
ESS-1 NF[yeYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PURmlEPTB;MD60O|gzOSEQvF2= MYHTRW5ITVJ?
KARPAS-45 NFzpVIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq2SJBKSzVyPUCuOFg6OzNizszN NEHofXRUSU6JRWK=
DU-4475 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37XdGlEPTB;MD60PVUyOSEQvF2= M3LCbXNCVkeHUh?=
VMRC-RCZ M132[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT2U5E1UUN3ME2wMlQ6QTB2IN88US=> NIPIbGdUSU6JRWK=
HOS MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y4UWlEPTB;MD61NFM3PSEQvF2= MkTPV2FPT0WU
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D-542MG NH;FUoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLYTWM2OD1zLki1PFUyKM7:TR?= NILmXpVUSU6JRWK=
KNS-42 Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHmTWM2OD1zLki2NlY3KM7:TR?= MYfTRW5ITVJ?
NCI-H2452 NEDFOnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{ntZWlEPTB;MT64PVA4PCEQvF2= MXjTRW5ITVJ?
SK-MEL-2 NXXsfpZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTFwOUCyO|Eh|ryP NV7yZ4p{W0GQR1XS
OVCAR-5 NWnIXYkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGS2[npKSzVyPUGuPVA3PzVizszN NYPGVHhVW0GQR1XS
SNG-M NHXIdWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzwWYhJUUN3ME2xMlk2QDV6IN88US=> NIe4NYhUSU6JRWK=
A673 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKyTWM2OD1zLkm3OVE3KM7:TR?= MVrTRW5ITVJ?
L-428 MmO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTidZczUUN3ME2xMlk6OTd7IN88US=> NYrLdm5oW0GQR1XS
KM-H2 NEXBeGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mme4TWM2OD1{LkCxNFkh|ryP MV7TRW5ITVJ?
MC-IXC MoDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULqT48yUUN3ME2yMlAzOjd|IN88US=> NFjEfnRUSU6JRWK=
COLO-678 NI[2U4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfKeHFbUUN3ME2yMlA1OjB5IN88US=> NIW1eGJUSU6JRWK=
MEL-JUSO NHLLUZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGGzRZNKSzVyPUKuNFc5PTFizszN M4q4VnNCVkeHUh?=
HCC38 NEfoc3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M165OmlEPTB;Mj6wPFQ{OyEQvF2= M37nRnNCVkeHUh?=
UACC-62 NFXlR3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHFS5Q4UUN3ME2yMlA5QDV3IN88US=> NIPp[VFUSU6JRWK=
OAW-42 M4rtcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJwMEm3NVEh|ryP MWLTRW5ITVJ?
LB996-RCC NW\uU5ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDHTWM2OD1{LkGzPFE4KM7:TR?= M1fkd3NCVkeHUh?=
COR-L105 Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrseXlKSzVyPUKuNVY{PzNizszN M{X6NnNCVkeHUh?=
RCC10RGB MkCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHGeZh{UUN3ME2yMlE5PTd4IN88US=> MXHTRW5ITVJ?
A431 M13vZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzKTWM2OD1{LkG5NFE6KM7:TR?= Ml64V2FPT0WU
NCI-H292 NIjVWo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJwMkO5OVEh|ryP MorwV2FPT0WU
SK-UT-1 NVzRZ|FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:yN3dKSzVyPUKuN|MyQDRizszN M1TuN3NCVkeHUh?=
PANC-08-13 NF3NVJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjVT4tsUUN3ME2yMlM{OjN3IN88US=> MkLUV2FPT0WU
ST486 MnPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvuepVKSzVyPUKuOFExPDhizszN M3TnWHNCVkeHUh?=
SJSA-1 MkTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7acIhKSzVyPUKuOFEzPzFizszN NFHZ[GlUSU6JRWK=
RKO MmLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXWTWM2OD1{LkSyNFI6KM7:TR?= NFzXT|hUSU6JRWK=
NCI-H1793 NVjDU5lTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jPOGlEPTB;Mj60OFAzQSEQvF2= M2i3[3NCVkeHUh?=
639-V MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXnR|RKSzVyPUKuOFU{QDJizszN MkPKV2FPT0WU
ES3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJwNEm3N|ch|ryP NXm3VVM5W0GQR1XS
NCI-H1792 NWTFToZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTJwNU[4NlYh|ryP MUfTRW5ITVJ?
NCI-H1651 NYrpNHFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYKwWYl1UUN3ME2yMlU5OjFizszN M{ixeXNCVkeHUh?=
SN12C MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DxW2lEPTB;Mj61PFQ5PyEQvF2= M2fmeXNCVkeHUh?=
COLO-679 MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r6NWlEPTB;Mj61PFYxPSEQvF2= MoPNV2FPT0WU
U-118-MG NVvkPFZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHVVmdGUUN3ME2yMlU5QDd{IN88US=> NYT2TJlJW0GQR1XS
Ramos-2G6-4C10 NFrxVHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJwNkS4NFch|ryP NU\BVHdKW0GQR1XS
HCT-15 MmXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJwNki3PVIh|ryP MkPOV2FPT0WU
MDA-MB-157 MmTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWexV3JHUUN3ME2yMlcxPzR5IN88US=> Ml[3V2FPT0WU
K5 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKwTWM2OD1{LkexPFQ2KM7:TR?= NWfBU2Z6W0GQR1XS
MKN45 MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUP0cndWUUN3ME2yMlc{OzZ4IN88US=> NW\MSXRmW0GQR1XS
DMS-273 MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nhTmlEPTB;Mj63OVY{OiEQvF2= MlHqV2FPT0WU
C8166 NYTTVpkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkCzTWM2OD1{Lke4OVE{KM7:TR?= NEHL[I9USU6JRWK=
Calu-3 NXnud3I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml71TWM2OD1{Lke4PVY6KM7:TR?= MUTTRW5ITVJ?
SNB75 M2DsTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfZfWh2UUN3ME2yMlg5PTN3IN88US=> NYjtSoFmW0GQR1XS
BFTC-905 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXJN|lKSzVyPUKuPVAyQTFizszN NGDSPVhUSU6JRWK=
C-4-II M1ixd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX64cmh3UUN3ME2yMlkyOzV|IN88US=> MULTRW5ITVJ?
MS-1 NEm1SFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJwOU[3Olkh|ryP M3LlXnNCVkeHUh?=
A375 NILwTVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLLTWM2OD1|LkC4NVg1KM7:TR?= MnW3V2FPT0WU
KYSE-70 NHuwVJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPES4Y1UUN3ME2zMlA5QDh{IN88US=> M2LjdXNCVkeHUh?=
KYSE-510 NETUPGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfuc4x7UUN3ME2zMlExQTl3IN88US=> MUHTRW5ITVJ?
LN-405 MnPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLPTWM2OD1|LkGzOVE5KM7:TR?= MVfTRW5ITVJ?
BOKU NFPXbFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TmRmlEPTB;Mz6xOFI2PiEQvF2= Mnu2V2FPT0WU
TE-10 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HKUmlEPTB;Mz6xO|M3OiEQvF2= MnPWV2FPT0WU
MKN1 MlHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfFTWM2OD1|LkG4OFg{KM7:TR?= MYTTRW5ITVJ?
M059J MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTNwMkCxO|Mh|ryP MVLTRW5ITVJ?
GOTO MkixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XuemlEPTB;Mz6yNlA{QSEQvF2= M1;0cHNCVkeHUh?=
DK-MG MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTNwMkW5O|Yh|ryP M3vYVnNCVkeHUh?=
NCI-H727 M3K2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTNwMk[1PEDPxE1? MmfKV2FPT0WU
NB12 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETKfolKSzVyPUOuN|MzOjRizszN NYXTd29[W0GQR1XS
DOK NYC1WYZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zkWWlEPTB;Mz6zOlE5PiEQvF2= M{HpbHNCVkeHUh?=
KYSE-410 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTNwM{[yPFch|ryP M1[3[nNCVkeHUh?=
AM-38 MmSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;WdZRKSzVyPUOuN|gxPTFizszN M1WwW3NCVkeHUh?=
GR-ST NIPpclBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTNwNEW3N|Ih|ryP MorOV2FPT0WU
D-247MG NVHWbG5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXvd|ZKSzVyPUOuOFgzPjNizszN MV;TRW5ITVJ?
TE-8 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTNwNEmzN|Mh|ryP MnvPV2FPT0WU
LS-411N NHnaTFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTNwNEm2PVIh|ryP NWHSbFBiW0GQR1XS
SK-MES-1 NInJOoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvLTWM2OD1|LkW2OFM{KM7:TR?= Mmq0V2FPT0WU
SF295 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUG3eGRXUUN3ME2zMlYyPTV{IN88US=> NYWze3RMW0GQR1XS
SK-MEL-30 M1rMbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvUTWM2OD1|Lk[1PVIyKM7:TR?= M3XxZXNCVkeHUh?=
LB2241-RCC M2m1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTNwNk[yOkDPxE1? NXvZXpBpW0GQR1XS
PC-14 NFTk[Y5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPZSnFRUUN3ME2zMlY3PDN5IN88US=> M{\kfHNCVkeHUh?=
EW-7 M2X0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfzdpBKSzVyPUOuOlc3QTNizszN NFn5VW9USU6JRWK=
NMC-G1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jGVWlEPTB;Mz63NVg{PyEQvF2= NVnuPG5xW0GQR1XS
TE-441-T NW\oZVlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\jNWlEPTB;Mz63N|AzQCEQvF2= MYLTRW5ITVJ?
NCI-H1618 NXvn[YVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrLWY46UUN3ME2zMlgyQDd3IN88US=> NInDfoxUSU6JRWK=
PANC-03-27 NFnncXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHxTWM2OD1|LkixPVE3KM7:TR?= NYXLN3M3W0GQR1XS
NCI-H2228 NUK2OHp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfrTWM2OD1|LkizNVI3KM7:TR?= NXLySGJKW0GQR1XS
CAPAN-1 M2KxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTNwOEewNFkh|ryP M1zF[XNCVkeHUh?=
KLE NYrYfVhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK1R4xTUUN3ME2zMlkxPjdizszN M3;R[3NCVkeHUh?=
Becker NUfwSWx4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTNwOUK4OFkh|ryP NETxcVFUSU6JRWK=
SK-PN-DW M4C2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTRwMEe5O|Qh|ryP MnjwV2FPT0WU
Hs-578-T M4eyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHjenpbUUN3ME20MlA5OzB4IN88US=> MVTTRW5ITVJ?
RS4-11 NInqTIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7UWWhKSzVyPUSuNVEzPTVizszN Ml2yV2FPT0WU
D-502MG MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHuTWM2OD12LkG2PVk4KM7:TR?= MkjGV2FPT0WU
GI-1 NGTofmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq2XodKSzVyPUSuNlgzQTlizszN M3mxXnNCVkeHUh?=
NCI-H209 M2rJeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS4elFKSzVyPUSuN|M4QCEQvF2= NEXnV2xUSU6JRWK=
SK-OV-3 M2G2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DiWGlEPTB;ND60PFE1QSEQvF2= M4DmNXNCVkeHUh?=
LOUCY NEfCeWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:ze2lEPTB;ND60PFQ{OiEQvF2= MU\TRW5ITVJ?
NCI-H69 MlP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLIV4NJUUN3ME20MlUyPzl|IN88US=> NYfSUHJRW0GQR1XS
SCC-9 NIDrWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jocGlEPTB;ND61N|E4OiEQvF2= NH\mNHZUSU6JRWK=
NCI-H526 M{fVfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfOTWM2OD12LkW5Nlk{KM7:TR?= M13BXXNCVkeHUh?=
NCI-H2170 NF3uOXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXq1eFNsUUN3ME20MlY3PzdzIN88US=> NHHLUGtUSU6JRWK=
SR NFTFcpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTBXXQ2UUN3ME20MlcxODR6IN88US=> Mn;sV2FPT0WU
CMK MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHyXW1KSzVyPUSuO|IyODFizszN Mnr4V2FPT0WU
COLO-829 M163W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2K5OmlEPTB;ND63O|A1OyEQvF2= M{K0fnNCVkeHUh?=
HuO-3N1 NWDDTo9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnifnhKSzVyPUSuPFMzQDFizszN MoTvV2FPT0WU
5637 NHLv[GZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjzWZM5UUN3ME20MlkxPDh5IN88US=> M3rpV3NCVkeHUh?=
A253 NF\5NZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ni[GlEPTB;ND65O|cxQCEQvF2= NF3XfpdUSU6JRWK=
NB10 NXnBcIpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnv0TWM2OD13LkC3OFk4KM7:TR?= M{DBdXNCVkeHUh?=
SF539 Mk\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTVwMEm5OVkh|ryP MYDTRW5ITVJ?
HAL-01 NInhZphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTVwMUS2OFUh|ryP NYHZVnd4W0GQR1XS
MHH-ES-1 MnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHic5N[UUN3ME21MlE3QTJ3IN88US=> NFvDUHhUSU6JRWK=
DEL M{XUWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTVwMke1PFIh|ryP MWHTRW5ITVJ?
NCI-H1299 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTVwM{WwNFch|ryP NFHjPIdUSU6JRWK=
ChaGo-K-1 NGDOXpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\QS5hiUUN3ME21MlM2OTB5IN88US=> MYLTRW5ITVJ?
HMV-II MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3xbYZKSzVyPUWuN|k1OyEQvF2= NWmwVI9qW0GQR1XS
NB69 NUDIdXJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[xWWlEPTB;NT6zPVY{OSEQvF2= NWna[pdkW0GQR1XS
NCI-H1882 NUPxd4dbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nDVGlEPTB;NT60N|M3PCEQvF2= MXfTRW5ITVJ?
SNU-475 MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnjTWM2OD13LkS3NVcyKM7:TR?= NEDzS4xUSU6JRWK=
RXF393 M1nJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XISWlEPTB;NT60PFQ6PCEQvF2= M{joNXNCVkeHUh?=
CAL-51 NULnUFN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTVwNkK4OVMh|ryP M3WwVHNCVkeHUh?=
SW1573 M1nFV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXMW|g2UUN3ME21MlY{PTN2IN88US=> MYPTRW5ITVJ?
GCT NWnvb4ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjlZ4l5UUN3ME21Mlc2QTJ7IN88US=> NV\HNYw6W0GQR1XS
COR-L88 NFH5cVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TQ[GlEPTB;NT63Olg1PiEQvF2= M1LpXHNCVkeHUh?=
MDA-MB-134-VI NXf2ZXpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TubWlEPTB;NT64O|U{PiEQvF2= NFG2Sm5USU6JRWK=
NB5 NF7jb5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjKS2ZwUUN3ME21MlkzPDRizszN M2\BZXNCVkeHUh?=
GMS-10 NXewTWJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIqxNVhKSzVyPUWuPVY5PjFizszN NVP4Xow3W0GQR1XS
CHP-212 NYXqfW1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLVTWM2OD14LkS4NlY4KM7:TR?= NGTHR5hUSU6JRWK=
TE-11 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnsTWM2OD14LkW1NVgzKM7:TR?= NUjVbmlnW0GQR1XS
SW962 NEnreVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVv3SnN7UUN3ME22MlY2Pzd2IN88US=> M1\4cXNCVkeHUh?=
MZ2-MEL NHvaO4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{f0W2lEPTB;Nj64NlAyOSEQvF2= NFvlUIRUSU6JRWK=
C-33-A M{XVNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXrTWM2OD14LkmxOlg5KM7:TR?= M4ezd3NCVkeHUh?=
IGR-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTZwOUe4NlYh|ryP MkL0V2FPT0WU
MOLT-4 NHK5eVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTdwMUW0NFYh|ryP NGfXcIhUSU6JRWK=
NCI-H1650 NFrBW2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jDOGlEPTB;Nz6yO|A1PiEQvF2= Ml;JV2FPT0WU
AsPC-1 NIKzSodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTdwMki2NFUh|ryP NWPseXNDW0GQR1XS
SNU-C2B NHvLR5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfDZVE2UUN3ME23MlI6PTdzIN88US=> MYDTRW5ITVJ?
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HCE-T MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XnT2lEPTB;MkKuPFYxPiEQvF2= MmrvV2FPT0WU
BB65-RCC M3[2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPwTWM2OD1{Mz6wN|Q1KM7:TR?= MlzpV2FPT0WU
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LNCaP-Clone-FGC M3HU[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:4U2lEPTB;MkWuN|Q6QCEQvF2= MYDTRW5ITVJ?
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OE33 NFjESIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLZW|BpUUN3ME2yOU43QDV|IN88US=> MWDTRW5ITVJ?
HT-29 NHr1[WpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTpTWM2OD1{NT63PFc6KM7:TR?= M{DpWHNCVkeHUh?=
RCM-1 NGjNZlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJ3Lkm2OVYh|ryP NIrFZZFUSU6JRWK=
NCI-H1522 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M12xNWlEPTB;MkWuPVkyOSEQvF2= NHzRfXBUSU6JRWK=
LB373-MEL-D M1rs[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP2eoJDUUN3ME2yOk4yPzB6IN88US=> NF;HN5JUSU6JRWK=
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COLO-824 MkW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3ETWM2OD1{Nj60NFAzKM7:TR?= MWLTRW5ITVJ?
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LAN-6 NF21XFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTJ5LkO1PVgh|ryP NGmybnRUSU6JRWK=
GAK MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[2TWM2OD1{Nz60NlI2KM7:TR?= MXHTRW5ITVJ?
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UACC-257 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\rTWM2OD1{Nz62PFc5KM7:TR?= NWTSR4dUW0GQR1XS
SW1783 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjuN3pFUUN3ME2yO{44Pzh|IN88US=> NX7CfZRKW0GQR1XS
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RL M2HRemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP3XJJyUUN3ME2yPE42QTFzIN88US=> Mn3BV2FPT0WU
TK10 NHHTOGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\IfGlEPTB;MkiuOlU{PSEQvF2= M4\jSHNCVkeHUh?=
HT55 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJ7LkC1OlUh|ryP MWXTRW5ITVJ?
BT-20 MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHi[4JxUUN3ME2yPU4xPTh4IN88US=> NHLISWhUSU6JRWK=
TGBC24TKB MkfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;wTWM2OD1{OT6xPFMyKM7:TR?= NVu1XZB[W0GQR1XS
HSC-2 M2jqZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\iTWM2OD1{OT6zNFAyKM7:TR?= Mm\hV2FPT0WU
COLO-205 Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LMc2lEPTB;MkmuN|k1PCEQvF2= M3TzUHNCVkeHUh?=
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PFSK-1 Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTNzLkK2OVkh|ryP MoTUV2FPT0WU
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RD M16ycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[xTWM2OD1|MT61NVE2KM7:TR?= M2XYenNCVkeHUh?=
NCI-H64 M{j3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmC4TWM2OD1|Mj60NVc6KM7:TR?= NFP0UIlUSU6JRWK=
DMS-114 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljoTWM2OD1|Mj60NVgzKM7:TR?= M{OxPHNCVkeHUh?=
NCI-H661 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXpW5dKSzVyPUOyMlY2ODFizszN Mo\YV2FPT0WU
CAL-148 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHiSmw4UUN3ME2zNk43PjZ3IN88US=> NELDbItUSU6JRWK=
HuP-T3 M{Kxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIGx[2lKSzVyPUOyMlk{OzhizszN NF7JU|BUSU6JRWK=
ES4 NFrwWZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTN|LkG3NFUh|ryP NHPZSG1USU6JRWK=
Ca9-22 MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzOUY9KSzVyPUOzMlQ3ODFizszN NU\0OlZGW0GQR1XS
LP-1 MofaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zNbGlEPTB;M{SuNFkh|ryP MWrTRW5ITVJ?
AU565 M3ftS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTN2LkWwOlkh|ryP MUDTRW5ITVJ?
MDA-MB-453 NG[5eINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LQWWlEPTB;M{WuNVQzPiEQvF2= NH7tOHZUSU6JRWK=
SNU-C1 M4DBfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mni0TWM2OD1|NT6xO|Eh|ryP MYrTRW5ITVJ?
SW13 NGDublZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkK3TWM2OD1|NT60NFc3KM7:TR?= MX7TRW5ITVJ?
NCI-H2122 NFX1Wo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4OzT2lEPTB;M{WuOVU6QCEQvF2= MWXTRW5ITVJ?
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ATN-1 MmnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLSToJKSzVyPUO2Mlg2OTZizszN NHX0[W5USU6JRWK=
HCC2998 M1L2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTN4Lki1O|Eh|ryP M3XieHNCVkeHUh?=
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HCC1599 NF;Pd|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTN5LkG2NVgh|ryP M{TN[nNCVkeHUh?=
UMC-11 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\iW2lEPTB;M{euNlUxOyEQvF2= NEHKdnhUSU6JRWK=
THP-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MornTWM2OD1|Nz6yPFY5KM7:TR?= MljlV2FPT0WU
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NCI-H1693 NYXhO2s{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zkcGlEPTB;M{euN|I{OyEQvF2= M1fTe3NCVkeHUh?=
NCI-H345 MlroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHi0co9KSzVyPUO3MlM3OjRizszN NEXKfGRUSU6JRWK=
COLO-800 M3LhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\2ZWlEPTB;M{euOVY4KM7:TR?= NITMT3dUSU6JRWK=
COLO-320-HSR NUHsO2VPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nkVWlEPTB;M{iuN|Q6OiEQvF2= MkftV2FPT0WU
NCI-H596 NGGyVYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXVTWM2OD1|OD60OFg6KM7:TR?= MmjqV2FPT0WU
NCI-H187 MonXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULYWWhGUUN3ME2zPE44OzR2IN88US=> MYrTRW5ITVJ?
ECC4 NU\neYRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LTPGlEPTB;M{muNFgyPCEQvF2= NEfrVopUSU6JRWK=
KP-4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnn[pE6UUN3ME2zPU4yOjN3IN88US=> MoT5V2FPT0WU
NCI-H2227 NFj5N5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\OcXRyUUN3ME2zPU4{QTR7IN88US=> M3XY[HNCVkeHUh?=
22RV1 NG[4XFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvxeFNKSzVyPUO5Mlg{QThizszN M2XYc3NCVkeHUh?=
SAS NXjNemtGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HDVWlEPTB;NECuNFk3KM7:TR?= NXrOVIN2W0GQR1XS
PANC-10-05 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmGzTWM2OD12MD6xPFI5KM7:TR?= MYPTRW5ITVJ?
MDA-MB-468 MnPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYGxfYVMUUN3ME20NE42OzR4IN88US=> M4Lab3NCVkeHUh?=
RPMI-7951 NXjWWm9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfnNW5oUUN3ME20NU4zODd3IN88US=> MUPTRW5ITVJ?
BB49-HNC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPSNHBKSzVyPUSxMlIyPzlizszN MkjyV2FPT0WU
23132-87 NYL4cHV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTRzLkK3N|Ih|ryP NGX4SIFUSU6JRWK=
HCC1569 M{S1e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XUSGlEPTB;NEGuNlg5PSEQvF2= NH\kZ|VUSU6JRWK=
CP66-MEL NFvhbFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnwW21KSzVyPUSyMlE5QDZizszN NXy0[I5uW0GQR1XS
K-562 NEO2UppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzPTJpRUUN3ME20Nk4zQDV2IN88US=> MmDUV2FPT0WU
OCI-AML2 M1H0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDwTWM2OD12Mj64PVc1KM7:TR?= Ml;UV2FPT0WU
SW756 MnrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTR|LkCzPFgh|ryP MYfTRW5ITVJ?
M14 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPRVo0yUUN3ME20N{4{OTh7IN88US=> NYK5XXI1W0GQR1XS
NCI-H1623 NFv5OFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkO4TWM2OD12Mz60OlQh|ryP M{iyUnNCVkeHUh?=
KNS-81-FD M2jVVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrVRm1KUUN3ME20N{44PjJizszN NUK3W|J6W0GQR1XS
TGBC1TKB NELxZWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTR|LkmwPVkh|ryP NG\MdZVUSU6JRWK=
RERF-LC-MS MoLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTR|LkmyPFEh|ryP M3rFO3NCVkeHUh?=
PC-3 MkLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M324b2lEPTB;NESuOFM1PyEQvF2= M2HCSXNCVkeHUh?=
HuP-T4 MkTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfFcYVKSzVyPUS0MlQ1PzRizszN M3;3b3NCVkeHUh?=
NCI-H510A MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jGT2lEPTB;NESuO|A5KM7:TR?= MXHTRW5ITVJ?
LB2518-MEL NXzDbpFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTR2Lke5N|ch|ryP M32zPXNCVkeHUh?=
TE-5 NIHyeJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTR3Lkm1PFEh|ryP NXPaVVNrW0GQR1XS
EW-24 NFTTc|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrDTWM2OD12Nj6xO|I{KM7:TR?= MUXTRW5ITVJ?
LB647-SCLC NH;IdYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTR4LkKxOVUh|ryP NVjBW|FXW0GQR1XS
NCI-H524 NGPnZ|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XzOmlEPTB;NE[uO|E5PSEQvF2= NFX0emtUSU6JRWK=
EW-11 M2\2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXu0RlZ5UUN3ME20Ok46Ozd|IN88US=> NIP5[pBUSU6JRWK=
KALS-1 M1PG[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnFbJN1UUN3ME20O{4zODZ4IN88US=> NV3lfYNtW0GQR1XS
BT-474 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rCXGlEPTB;NEeuOFIyPiEQvF2= MYjTRW5ITVJ?
SK-N-AS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEe2SlZKSzVyPUS3Mlg5QCEQvF2= NH3UZlhUSU6JRWK=
HCC2157 MlvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jhR2lEPTB;NEiuNFc3KM7:TR?= MVzTRW5ITVJ?
HCC1954 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTR6LkG3NFQh|ryP M2LLOnNCVkeHUh?=
FADU MkX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTR6LkOwN|Eh|ryP NGHtWVNUSU6JRWK=
S-117 M3HmRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TBOmlEPTB;NEiuN|gyPSEQvF2= NEOycGxUSU6JRWK=
LS-1034 MlH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nWe2lEPTB;NEiuO|A3PyEQvF2= NHHQVmRUSU6JRWK=
CAMA-1 NXjnXmg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrTOGhKSzVyPUS5MlU2PDNizszN NGfLTGpUSU6JRWK=
LU-134-A MlPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTR7LkiwPFUh|ryP M3X1b3NCVkeHUh?=
NCI-H1838 M{DzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTR7LkiwPFch|ryP M175fHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

体内研究 Ponatinib抑制取自FLT3-ITD阳性AML病人的原代白血病细胞,而不抑制表达阴性FLT3的AML病人的白血病细胞。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
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激酶实验:

通过同质时间分辨荧光共振能量转移法(TR-FRET),使用纯化的人类野生型ABL激酶,T315I突变型ABL激酶,及生物素化的磷酸激酶底物肽: 生物素-EKKMAAEAIYAAPFAK-NH2,测定野生型ABL和T315I突变型ABL活性的抑制激酶反应在全LANCE激酶buffer (LKB)中进行,LKB包括20 mM NaHEPES(pH 为7.4), 0.1 mg ⁄ mL BSA, 1 mM ATP, 10 mM MgCl2, 及0.41 mM DTT,在提前用1% BSA(溶于PBS)包被的96孔板上4oC下过夜。用于激酶反应,Ponatinib稀释物和野生型ABL, T315I突变型ABL (40 pM), 及底物肽(50 nM), 在室温下温育1小时(T315I突变型ABL)或2小时(野生型ABL)。加入15 nM 抑制剂, 6 nM 铕标记的磷酸酪氨酸抗体(磷酸化位点在第66为酪氨酸上),及60 nM 别藻蓝素标记的链酶亲和素,终止反应。实验板在室温下黑暗温育20分钟,使用Wallac Victor2V读数器读取615和665nm处的荧光值。在孔中数据平均值中插入抑制剂的3倍连续稀释液,再读取665nm处荧光值,计算IC50值。
细胞实验:[1]
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  • Cell lines: Ba ⁄ F3细胞
  • Concentrations: 0-625 nM, 和0-10 µM
  • Incubation Time: 72小时
  • Method: Ba/F3细胞系按每孔4×103个细胞分布在96孔板上(4×103),和梯度浓度Ponatinib温育72小时。Ponatinib浓度范围为: 0-625 nM 作用于表达BCR-ABL细胞,0-10 µM 用于测定BCR-ABL阴性细胞。使用MTS实验测定细胞增殖,取三次平行实验平均值测定IC50值。
    (Only for Reference)
动物实验:[3]
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  • Animal Models: 皮下植入MV4-11细胞移植瘤(1×107,50%基质胶中) 的雌性CB.17 SCID鼠
  • Formulation: 25 mmol/L柠檬酸盐缓冲液(pH 为2.75)
  • Dosages: 每天处理一次,持续4周
  • Administration: 口服饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
1% CMC Na
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 532.56
化学式

C29H27F3N6O

CAS号 943319-70-8
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID