Ponatinib (AP24534)

目录号:S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。

规格 价格 库存 购买数量  
RMB 819.31 现货
RMB 903.01 现货
RMB 3034.48 现货
RMB 7959.08 现货
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客户使用该产品的4个实验数据:

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。
靶点
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外研究

Ponatinib是有效的可用于口服的多靶点激酶抑制剂,作用于野生型细胞,及T315I 突变细胞IC50分别为1.2和8.8nM。[1] Ponatinib抑制Ba/F3衍生细胞系的增殖。[2] Ponatinib作用于表达野生型或T315I突变型BCR-ABL的CML细胞系,有效抑制BCR-ABL调节的信号。Ponatinib阻断在细胞瘤筛选时产生抗性突变。[3] Ponatinib也抑制VEGFR和FGFR家族激酶,在体外抑制FLT3, KIT, FGFR1,和PDGFRa激酶活性时IC50分别为13, 13, 2, 和1 nM.[4]Ponatinib抑制全部4种RTKs磷酸化,存在剂量依赖性,IC50值为0.3到20 nM。然而,Ponatinib抑制表达野生型FLT3的RS4;11细胞时IC50>100 nM。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MnzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7mWW14UUN3ME2wMlAxODByMECzOVkh|ryP NV3jdmNzW0GQR1XS
MV-4-11 NV7MTGZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3i2VGlEPTB;MD6wNFAxQTV4IN88US=> Mmj6V2FPT0WU
MEG-01 Mn\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMECwNVI5KM7:TR?= NWCyfI9XW0GQR1XS
LAMA-84 NVzDSmtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljNTWM2OD1yLkCwNFE3PSEQvF2= MXrTRW5ITVJ?
CGTH-W-1 MlvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPvdnQ2UUN3ME2wMlAxOTZ7IN88US=> M1jhcnNCVkeHUh?=
KASUMI-1 MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonrTWM2OD1yLkCwNlE4KM7:TR?= NVrHS5g6W0GQR1XS
BE-13 M{TybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[3UXhzUUN3ME2wMlAxOjV7IN88US=> NWHlZplDW0GQR1XS
CTV-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTB[o1HUUN3ME2wMlAxPTJzIN88US=> MUfTRW5ITVJ?
NKM-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjjTVNKSzVyPUCuNFA3PTVizszN MU\TRW5ITVJ?
MONO-MAC-6 NG\EemhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{f6fGlEPTB;MD6wNFg{PyEQvF2= M{P5dnNCVkeHUh?=
A204 NYjtRmV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L4S2lEPTB;MD6wNVIyQCEQvF2= M{G3OHNCVkeHUh?=
GDM-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTPTWM2OD1yLkCxPFM{KM7:TR?= MUPTRW5ITVJ?
AN3-CA MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTTTWM2OD1yLkCxPFc{KM7:TR?= Mni3V2FPT0WU
BL-70 NV76Xo9zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrNeXkzUUN3ME2wMlAzOTl7IN88US=> MonrV2FPT0WU
Daudi NX71NlJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTkfG9KSzVyPUCuNFI2OzdizszN MV7TRW5ITVJ?
KU812 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEK4OFgh|ryP MmDZV2FPT0WU
KG-1 NX\NcYFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEOyPVQh|ryP NFPE[XpUSU6JRWK=
DOHH-2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fS[GlEPTB;MD6wOFgxOyEQvF2= M1fDU3NCVkeHUh?=
HuO9 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEW0OFgh|ryP MoO4V2FPT0WU
EB2 NFKwdndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3rTWM2OD1yLkC1OVc3KM7:TR?= MYrTRW5ITVJ?
G-402 NUf1UJZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwME[zOFEh|ryP MoHQV2FPT0WU
SU-DHL-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PBW2lEPTB;MD6wOlM4QSEQvF2= NUfJd29kW0GQR1XS
NCI-H719 M4[xWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j0eGlEPTB;MD6wO|g5QCEQvF2= NXnWOWlLW0GQR1XS
MLMA NIOxSG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HzfWlEPTB;MD6wPVA3KM7:TR?= M4e3OnNCVkeHUh?=
KM12 MmfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXne3N7UUN3ME2wMlA6PzN5IN88US=> NXXDfXNiW0GQR1XS
SUP-T1 NH\GSXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1L1dmlEPTB;MD6wPVk5OiEQvF2= Ml3FV2FPT0WU
MZ1-PC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMUGzN|Yh|ryP NFuwRoJUSU6JRWK=
MFE-296 M3ftRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[0dYVjUUN3ME2wMlEyQDN7IN88US=> M13lXXNCVkeHUh?=
ALL-PO MoLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHUU|ZKSzVyPUCuNVI1PDNizszN NHe2OXpUSU6JRWK=
GB-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3juXWlEPTB;MD6xNlUyOiEQvF2= Mk[1V2FPT0WU
SIG-M5 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XMeGlEPTB;MD6xN|M4KM7:TR?= MljWV2FPT0WU
P30-OHK M2PxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMUW2O|Ih|ryP MkT6V2FPT0WU
NCI-H716 M3Lh[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX0TWM2OD1yLkG2NlY3KM7:TR?= MVfTRW5ITVJ?
MPP-89 Mk\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMU[5N|Mh|ryP MWnTRW5ITVJ?
SF126 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LqT2lEPTB;MD6xO|A3OyEQvF2= NEnEPYhUSU6JRWK=
CTB-1 M2rJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M36weWlEPTB;MD6xO|MyPiEQvF2= NHztdIRUSU6JRWK=
CA46 MmPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXIflZSUUN3ME2wMlE4PDh7IN88US=> M3Llb3NCVkeHUh?=
NCI-H520 M1jnTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMUe3N|Ih|ryP M4PlfnNCVkeHUh?=
CAL-85-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTRTWM2OD1yLkG3PVI4KM7:TR?= M4K2T3NCVkeHUh?=
NCI-H2342 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMUi1O|ch|ryP MkKyV2FPT0WU
697 NE\VXnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnYU2JKSzVyPUCuNVg5PzFizszN MX7TRW5ITVJ?
NY M37Mc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O2fmlEPTB;MD6xPVI5PyEQvF2= MlzIV2FPT0WU
T98G NHvOdm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LSPGlEPTB;MD6xPVMyQCEQvF2= NV\nZlhuW0GQR1XS
NCI-H1703 M{HyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLPTWM2OD1yLkG5OlE2KM7:TR?= MlyzV2FPT0WU
NCI-H2087 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLTbVdpUUN3ME2wMlIxPDN7IN88US=> M{TjbHNCVkeHUh?=
PF-382 MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTzTWM2OD1yLkKwPFc{KM7:TR?= MUPTRW5ITVJ?
HCT-116 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEC2TYZKSzVyPUCuNlExPjlizszN NVXUeoVVW0GQR1XS
CAKI-1 M{DiN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjRU29SUUN3ME2wMlIyPjZ4IN88US=> M1nQO3NCVkeHUh?=
CCF-STTG1 NG\lXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\DTWM2OD1yLkKyOFc2KM7:TR?= MV7TRW5ITVJ?
D-392MG M{L6dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fmNmlEPTB;MD6yN|E4PyEQvF2= MXXTRW5ITVJ?
RT-112 NGLZNlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2izbGlEPTB;MD6yN|c6PSEQvF2= M2jOOnNCVkeHUh?=
MES-SA MnS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fDPWlEPTB;MD6yOFE5PyEQvF2= MnywV2FPT0WU
LC-2-ad NVnR[|ZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4mzR2lEPTB;MD6yOFI3PSEQvF2= M{j3O3NCVkeHUh?=
NOS-1 NHPS[FRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXNUIFKSzVyPUCuNlQ{PjdizszN MXXTRW5ITVJ?
NALM-6 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjwTHY1UUN3ME2wMlI2PTR|IN88US=> NX;yRZR4W0GQR1XS
TE-15 M3[4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMk[wPVEh|ryP NUDvOnFlW0GQR1XS
786-0 NFmxbIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTwTWM2OD1yLkK2NlI5KM7:TR?= M1v4PHNCVkeHUh?=
IST-MES1 NFrMNGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMk[4Nlkh|ryP NITGfmZUSU6JRWK=
KYSE-180 Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIL5eYNKSzVyPUCuNlY5QTFizszN MX\TRW5ITVJ?
YT NX2xcHl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HNOWlEPTB;MD6yOlk4PCEQvF2= NW\BVWVGW0GQR1XS
A427 M1;qTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfWR3Y3UUN3ME2wMlI4OjZ2IN88US=> NXzKZoo{W0GQR1XS
KYSE-450 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvqc4ZmUUN3ME2wMlI4OzJ7IN88US=> NHrYbWpUSU6JRWK=
HuH-7 NW\IZ5VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHniN3FKSzVyPUCuNlc4PjNizszN MY\TRW5ITVJ?
CAS-1 MluwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfBNJdPUUN3ME2wMlI5OzB|IN88US=> NUHCUmZ3W0GQR1XS
KURAMOCHI MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;LVpNKSzVyPUCuNlg1OTlizszN NGHrdXZUSU6JRWK=
ACHN M1TONWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHldZFKSzVyPUCuNlk{OjNizszN MmnKV2FPT0WU
HGC-27 NUHpeWdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXwOplKSzVyPUCuNlk{PTNizszN Ml7lV2FPT0WU
A172 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHO5OmNKSzVyPUCuNlk2PzdizszN NWXDZYw1W0GQR1XS
SNU-449 NH\qZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnyTWM2OD1yLkK5PVY1KM7:TR?= MojlV2FPT0WU
SW982 NWDYdVhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMkm5O|gh|ryP NF7heIpUSU6JRWK=
EFO-21 NFT2d4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnTVIpKSzVyPUCuN|A1OTFizszN MonZV2FPT0WU
NCI-H2030 MljyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwM{GxOlQh|ryP NIHVbJZUSU6JRWK=
HT-144 M4T3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TJVGlEPTB;MD6zNVI5KM7:TR?= NWqycot5W0GQR1XS
MFE-280 NHTmbFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYixRYdWUUN3ME2wMlMyPDV|IN88US=> M2HRN3NCVkeHUh?=
SK-LU-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFywbJVKSzVyPUCuN|E1PjZizszN M2Toe3NCVkeHUh?=
NCI-H2052 NXLETYt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwM{G0PFQh|ryP M1vS[nNCVkeHUh?=
SK-HEP-1 M2XsUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXsTWM2OD1yLkOzN|Y5KM7:TR?= NVu1dJpwW0GQR1XS
QIMR-WIL NHTtU2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwM{O0NlQh|ryP MXvTRW5ITVJ?
A2780 NF30S|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmftTWM2OD1yLkO0N|A1KM7:TR?= MonNV2FPT0WU
ACN MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwM{S4O|Mh|ryP NF\6N21USU6JRWK=
BxPC-3 NHLCUZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfGTWM2OD1yLkO0PVg6KM7:TR?= Mn[xV2FPT0WU
BCPAP NH\LUHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHwToNKSzVyPUCuN|YxODFizszN M2nsUHNCVkeHUh?=
HOP-62 NFvtfG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3vRlZKSzVyPUCuN|YyODZizszN M2PVfXNCVkeHUh?=
SW1710 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vyN2lEPTB;MD6zOlQ2PSEQvF2= Mo[0V2FPT0WU
OPM-2 NFzUc3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4L3VGlEPTB;MD6zOlQ4OyEQvF2= NHPLXJBUSU6JRWK=
DBTRG-05MG MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLpNW9RUUN3ME2wMlM5ODV2IN88US=> M3jTWnNCVkeHUh?=
SK-MEL-24 NFTie2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkGxTWM2OD1yLkO5O|kyKM7:TR?= Mm[0V2FPT0WU
8305C M2jodWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rsbGlEPTB;MD6zPVc6OyEQvF2= M3fhcHNCVkeHUh?=
OVCAR-4 M{KxNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn70TWM2OD1yLkSxOVg3KM7:TR?= Ml3XV2FPT0WU
HLE M4nIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNEG4OkDPxE1? M{CxZ3NCVkeHUh?=
NCI-H747 M1fZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rTUGlEPTB;MD60NlE{PyEQvF2= NIW4e2ZUSU6JRWK=
SW780 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vrdGlEPTB;MD60NlM1PiEQvF2= M4KzTnNCVkeHUh?=
KYSE-150 M3;qPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwNEK0NVUh|ryP Mn;wV2FPT0WU
H4 MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHzb3hzUUN3ME2wMlQzPDVzIN88US=> MlH3V2FPT0WU
SW1088 M3jOXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwNESzPUDPxE1? NIHlc|NUSU6JRWK=
SF268 NEHHbHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrsTWM2OD1yLkS0PFYh|ryP MUXTRW5ITVJ?
RT4 M2HtV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHH6XIVKSzVyPUCuOFUyOTFizszN NH\qTGVUSU6JRWK=
NCI-H522 NHfH[IpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnvTWM2OD1yLkS1Nlch|ryP MoPuV2FPT0WU
LCLC-97TM1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLFVZRKSzVyPUCuOFYyQTVizszN MVjTRW5ITVJ?
CAL-39 Mnq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHOTWM2OD1yLkS2OVE6KM7:TR?= MnHkV2FPT0WU
CAL-120 NGiy[GNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vZTWlEPTB;MD60O|Y1OyEQvF2= MX3TRW5ITVJ?
ESS-1 M4[4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjWdVZuUUN3ME2wMlQ4QDJzIN88US=> NUHJbGhNW0GQR1XS
KARPAS-45 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIe4b5hKSzVyPUCuOFg6OzNizszN MV3TRW5ITVJ?
DU-4475 Mm\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULLeYJzUUN3ME2wMlQ6PTFzIN88US=> M3nsPXNCVkeHUh?=
VMRC-RCZ M3zWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfVdZlKSzVyPUCuOFk6ODRizszN NYfUb2prW0GQR1XS
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D-542MG NYDhOZMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrnTWM2OD1zLki1PFUyKM7:TR?= MWnTRW5ITVJ?
KNS-42 NXfIOHl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHTTWM2OD1zLki2NlY3KM7:TR?= MV\TRW5ITVJ?
NCI-H2452 MlHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITZbIhKSzVyPUGuPFkxPzRizszN MnqyV2FPT0WU
SK-MEL-2 M3:wXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M16wWWlEPTB;MT65NFI4OSEQvF2= NWC4OlVjW0GQR1XS
OVCAR-5 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXMTWM2OD1zLkmwOlc2KM7:TR?= MUDTRW5ITVJ?
SNG-M M3r6[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlv5TWM2OD1zLkm1PFU5KM7:TR?= NIXXb4hUSU6JRWK=
A673 NYjvUm85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrURXNKSzVyPUGuPVc2OTZizszN M3jiVHNCVkeHUh?=
L-428 NHzLVYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljXTWM2OD1zLkm5NVc6KM7:TR?= NGLJO5NUSU6JRWK=
KM-H2 NIjmOWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnqbXU5UUN3ME2yMlAyODlizszN MUHTRW5ITVJ?
MC-IXC M2PFXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJwMEKyO|Mh|ryP Mn;0V2FPT0WU
COLO-678 NH\kTYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TWW2lEPTB;Mj6wOFIxPyEQvF2= Mn;nV2FPT0WU
MEL-JUSO MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XjNmlEPTB;Mj6wO|g2OSEQvF2= Ml3XV2FPT0WU
HCC38 NWPaPYlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTJwMEi0N|Mh|ryP NWPUSFA1W0GQR1XS
UACC-62 NWPSbpVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTJwMEi4OVUh|ryP NGPJb5pUSU6JRWK=
OAW-42 NYDpcoE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;C[2dKSzVyPUKuNFk4OTFizszN MXTTRW5ITVJ?
LB996-RCC NYD1bZB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfmVZpRUUN3ME2yMlE{QDF5IN88US=> Mn[wV2FPT0WU
COR-L105 M1fNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXSfGdpUUN3ME2yMlE3Ozd|IN88US=> NEPLR3FUSU6JRWK=
RCC10RGB M{\INmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTJwMUi1O|Yh|ryP NVSxTHoyW0GQR1XS
A431 NWPjWXNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\0cXNKSzVyPUKuNVkxOTlizszN NUXOVY5EW0GQR1XS
NCI-H292 NYL5NZlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjHWHJKSzVyPUKuNlM6PTFizszN MkfkV2FPT0WU
SK-UT-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\yU401UUN3ME2yMlM{OTh2IN88US=> M{npbnNCVkeHUh?=
PANC-08-13 NITMR2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTJwM{OyN|Uh|ryP MYrTRW5ITVJ?
ST486 NEHrZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjyTWM2OD1{LkSxNFQ5KM7:TR?= M{XTV3NCVkeHUh?=
SJSA-1 MmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJwNEGyO|Eh|ryP M1vxenNCVkeHUh?=
RKO NH3WPItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LjbWlEPTB;Mj60NlAzQSEQvF2= NF\GOYxUSU6JRWK=
NCI-H1793 M4LNNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTJwNESwNlkh|ryP MnXkV2FPT0WU
639-V NXXKfFdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnK5TWM2OD1{LkS1N|gzKM7:TR?= NUDrb|VTW0GQR1XS
ES3 M{n2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\hTWM2OD1{LkS5O|M4KM7:TR?= Mn\TV2FPT0WU
NCI-H1792 M2TwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\6b|NqUUN3ME2yMlU3QDJ4IN88US=> NWT6fIpxW0GQR1XS
NCI-H1651 MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXtN5JKSzVyPUKuOVgzOSEQvF2= M371dHNCVkeHUh?=
SN12C NIe5c|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJwNUi0PFch|ryP Ml\SV2FPT0WU
COLO-679 NGPOd5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITsXlRKSzVyPUKuOVg3ODVizszN NID1bJRUSU6JRWK=
U-118-MG NF3m[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJwNUi4O|Ih|ryP NYfG[FZvW0GQR1XS
Ramos-2G6-4C10 Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTuTWM2OD1{Lk[0PFA4KM7:TR?= MX;TRW5ITVJ?
HCT-15 M2Lu[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTJwNki3PVIh|ryP MVjTRW5ITVJ?
MDA-MB-157 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\sbXdKSzVyPUKuO|A4PDdizszN MULTRW5ITVJ?
K5 NH7hbnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzSTWM2OD1{LkexPFQ2KM7:TR?= M3GySXNCVkeHUh?=
MKN45 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf6elNKSzVyPUKuO|M{PjZizszN NFrYd3BUSU6JRWK=
DMS-273 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTJwN{W2N|Ih|ryP NFHtNY5USU6JRWK=
C8166 MnXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnpWopKSzVyPUKuO|g2OTNizszN MlrnV2FPT0WU
Calu-3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknuTWM2OD1{Lke4PVY6KM7:TR?= M{PsfHNCVkeHUh?=
SNB75 NIrMXVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHMS4hKSzVyPUKuPFg2OzVizszN NEjUcGFUSU6JRWK=
BFTC-905 M2H1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrDTJo3UUN3ME2yMlkxOTlzIN88US=> NVT4eIwzW0GQR1XS
C-4-II NYDOOoxVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrQTllKSzVyPUKuPVE{PTNizszN M1HUOnNCVkeHUh?=
MS-1 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVGweXkzUUN3ME2yMlk3PzZ7IN88US=> M{L5VXNCVkeHUh?=
A375 Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTNwMEixPFQh|ryP NFv2OW1USU6JRWK=
KYSE-70 NYr0bJpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfPTWM2OD1|LkC4PFgzKM7:TR?= MUnTRW5ITVJ?
KYSE-510 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTNwMUC5PVUh|ryP NWfNTpMyW0GQR1XS
LN-405 MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTNwMUO1NVgh|ryP NUf3TXBDW0GQR1XS
BOKU M2LOb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf4fnNKSzVyPUOuNVQzPTZizszN MlLLV2FPT0WU
TE-10 NVryTGRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVe5VpNXUUN3ME2zMlE4OzZ{IN88US=> M{\5[3NCVkeHUh?=
MKN1 NYLWUWR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2L2dGlEPTB;Mz6xPFQ5OyEQvF2= M{[yUHNCVkeHUh?=
M059J MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zLbWlEPTB;Mz6yNFE4OyEQvF2= NVr6OGdVW0GQR1XS
GOTO MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTNwMkKwN|kh|ryP NF7FcYxUSU6JRWK=
DK-MG NHr6fZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzScFkxUUN3ME2zMlI2QTd4IN88US=> MYTTRW5ITVJ?
NCI-H727 M2HleGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlz6TWM2OD1|LkK2OVgh|ryP NUTHTFk3W0GQR1XS
NB12 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTNwM{OyNlQh|ryP M2jxZXNCVkeHUh?=
DOK MlW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlX5TWM2OD1|LkO2NVg3KM7:TR?= MlT3V2FPT0WU
KYSE-410 M4\Q[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvhTWM2OD1|LkO2Nlg4KM7:TR?= NGPGcolUSU6JRWK=
AM-38 MlfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rhN2lEPTB;Mz6zPFA2OSEQvF2= M3;hRXNCVkeHUh?=
GR-ST Ml3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTNwNEW3N|Ih|ryP NH7RRYVUSU6JRWK=
D-247MG MmLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLGdY1LUUN3ME2zMlQ5OjZ|IN88US=> M4T4[HNCVkeHUh?=
TE-8 NVrhO4ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTNwNEmzN|Mh|ryP MnjIV2FPT0WU
LS-411N NGrxN3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4K4NmlEPTB;Mz60PVY6OiEQvF2= MV;TRW5ITVJ?
SK-MES-1 NGSyVXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXoZ21xUUN3ME2zMlU3PDN|IN88US=> MWTTRW5ITVJ?
SF295 Mm\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T6[WlEPTB;Mz62NVU2OiEQvF2= NVXDTW9iW0GQR1XS
SK-MEL-30 MoXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zTUmlEPTB;Mz62OVkzOSEQvF2= NULUXoE{W0GQR1XS
LB2241-RCC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PhR2lEPTB;Mz62OlI3KM7:TR?= M1THfHNCVkeHUh?=
PC-14 NIjoO5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTJTWM2OD1|Lk[2OFM4KM7:TR?= NU\vfXNRW0GQR1XS
EW-7 NYPWS2FwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlSwTWM2OD1|Lk[3Olk{KM7:TR?= M3Hr[XNCVkeHUh?=
NMC-G1 MoPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCwUWJKSzVyPUOuO|E5OzdizszN NGS3e3JUSU6JRWK=
TE-441-T Mme2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Gx[GlEPTB;Mz63N|AzQCEQvF2= NIHpcmxUSU6JRWK=
NCI-H1618 M4WzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXHbFFxUUN3ME2zMlgyQDd3IN88US=> NF24WJZUSU6JRWK=
PANC-03-27 MnHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vMc2lEPTB;Mz64NVkyPiEQvF2= MWfTRW5ITVJ?
NCI-H2228 MnzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTNwOEOxNlYh|ryP MlH6V2FPT0WU
CAPAN-1 Ml74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTNwOEewNFkh|ryP M4LDXnNCVkeHUh?=
KLE NWrTWplwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Wyd2lEPTB;Mz65NFY4KM7:TR?= NXLJfWxNW0GQR1XS
Becker NITWTXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUWzWmJ3UUN3ME2zMlkzQDR7IN88US=> NV;JW2Q5W0GQR1XS
SK-PN-DW NUm4SYRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX5TWM2OD12LkC3PVc1KM7:TR?= MXnTRW5ITVJ?
Hs-578-T NWHpPGw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\NZXFKSzVyPUSuNFg{ODZizszN M4HDWnNCVkeHUh?=
RS4-11 NWnJO2hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTRwMUGyOVUh|ryP NXPRTZVoW0GQR1XS
D-502MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TOdWlEPTB;ND6xOlk6PyEQvF2= NFP1S2tUSU6JRWK=
GI-1 NUPufYVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;zd4F4UUN3ME20MlI5Ojl7IN88US=> M2\3[XNCVkeHUh?=
NCI-H209 NUD6WVR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHROG84UUN3ME20MlM{PzhizszN MlzxV2FPT0WU
SK-OV-3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnMOnRKSzVyPUSuOFgyPDlizszN NGLOOIdUSU6JRWK=
LOUCY NUPBdYg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjKbJVKSzVyPUSuOFg1OzJizszN NYHFWYpJW0GQR1XS
NCI-H69 MkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTRwNUG3PVMh|ryP M2LGenNCVkeHUh?=
SCC-9 M1\y[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjST5dKSzVyPUSuOVMyPzJizszN MUjTRW5ITVJ?
NCI-H526 NX3hdHpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmW4TWM2OD12LkW5Nlk{KM7:TR?= MknFV2FPT0WU
NCI-H2170 NY\v[oJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzkTWM2OD12Lk[2O|cyKM7:TR?= NW\N[lBFW0GQR1XS
SR M2DEVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTRwN{CwOFgh|ryP MV3TRW5ITVJ?
CMK M{DKVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3yTWM2OD12LkeyNVAyKM7:TR?= MYHTRW5ITVJ?
COLO-829 M1u5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlT1TWM2OD12Lke3NFQ{KM7:TR?= M4\xTnNCVkeHUh?=
HuO-3N1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{CwemlEPTB;ND64N|I5OSEQvF2= NHXuOllUSU6JRWK=
5637 MlHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\MbHZ2UUN3ME20MlkxPDh5IN88US=> NGn4VGhUSU6JRWK=
A253 NX21WWh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHv5W5FKSzVyPUSuPVc4ODhizszN NYfTXGMxW0GQR1XS
NB10 M2e3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrpcotjUUN3ME21MlA4PDl5IN88US=> MWjTRW5ITVJ?
SF539 NITtR4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3GzXmlEPTB;NT6wPVk2QSEQvF2= M4noT3NCVkeHUh?=
HAL-01 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fsWGlEPTB;NT6xOFY1PSEQvF2= Mlv1V2FPT0WU
MHH-ES-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXnTWM2OD13LkG2PVI2KM7:TR?= M{\SOXNCVkeHUh?=
DEL MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTVwMke1PFIh|ryP Mm\RV2FPT0WU
NCI-H1299 NGO4THRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{POXWlEPTB;NT6zOVAxPyEQvF2= MWDTRW5ITVJ?
ChaGo-K-1 Mon2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTIOHdKSzVyPUWuN|UyODdizszN M{CwW3NCVkeHUh?=
HMV-II M1W0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rXeGlEPTB;NT6zPVQ{KM7:TR?= MoDaV2FPT0WU
NB69 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO5TWM2OD13LkO5OlMyKM7:TR?= M1jWcHNCVkeHUh?=
NCI-H1882 M3XDZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVOwUWd{UUN3ME21MlQ{OzZ2IN88US=> MljhV2FPT0WU
SNU-475 NED6eIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\aSmlEPTB;NT60O|E4OSEQvF2= NY\BXnpmW0GQR1XS
RXF393 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTVwNEi0PVQh|ryP M3nsN3NCVkeHUh?=
CAL-51 M3jIU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTVwNkK4OVMh|ryP MYLTRW5ITVJ?
SW1573 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\Pe2lEPTB;NT62N|U{PCEQvF2= MVTTRW5ITVJ?
GCT NHjTXoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTVwN{W5Nlkh|ryP MVPTRW5ITVJ?
COR-L88 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTVwN{[4OFYh|ryP NVHZcYszW0GQR1XS
MDA-MB-134-VI MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFGzcJdKSzVyPUWuPFc2OzZizszN NV7zflRLW0GQR1XS
NB5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj0doZKSzVyPUWuPVI1PCEQvF2= NHrlPFZUSU6JRWK=
GMS-10 M3PEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\PdotFUUN3ME21Mlk3QDZzIN88US=> MWnTRW5ITVJ?
CHP-212 NVLMSJdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj6d2pKSzVyPU[uOFgzPjdizszN NV3qemg1W0GQR1XS
TE-11 NHrFNINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPxSXBWUUN3ME22MlU2OTh{IN88US=> MYfTRW5ITVJ?
SW962 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHOxOFlKSzVyPU[uOlU4PzRizszN NUjjTHhqW0GQR1XS
MZ2-MEL MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLYSIg6UUN3ME22MlgzODFzIN88US=> MlnlV2FPT0WU
C-33-A NHTQTXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLlZohKSzVyPU[uPVE3QDhizszN Mlr6V2FPT0WU
IGR-1 NUO4RlBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHIPFlKSzVyPU[uPVc5OjZizszN M3flUnNCVkeHUh?=
MOLT-4 NHrKeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLPTWM2OD15LkG1OFA3KM7:TR?= NHPqb3dUSU6JRWK=
NCI-H1650 M3LpXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTdwMkewOFYh|ryP M3f3OHNCVkeHUh?=
AsPC-1 MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTUTWM2OD15LkK4OlA2KM7:TR?= M{\PXXNCVkeHUh?=
SNU-C2B M3y5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXSb4ZKSzVyPUeuNlk2PzFizszN MnvoV2FPT0WU
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JVM-2 MmjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jWV2lEPTB;MkeuOlYzOiEQvF2= MY\TRW5ITVJ?
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TK10 M{PoZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHYUIpxUUN3ME2yPE43PTN3IN88US=> Mm\MV2FPT0WU
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NCI-H661 NIDMVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWyRnVMUUN3ME2zNk43PTBzIN88US=> MXTTRW5ITVJ?
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ATN-1 MlO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\oZVNNUUN3ME2zOk45PTF4IN88US=> NIfjZWtUSU6JRWK=
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OCUB-M NF;Jb3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTN5LkK4PVEh|ryP MWHTRW5ITVJ?
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KP-4 NFXDUnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S5eGlEPTB;M{muNVI{PSEQvF2= MlHXV2FPT0WU
NCI-H2227 NFvCU29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7ITWM2OD1|OT6zPVQ6KM7:TR?= MVLTRW5ITVJ?
22RV1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTN7LkizPVgh|ryP M3L3PHNCVkeHUh?=
SAS Mk\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvFb25KSzVyPUSwMlA6PiEQvF2= MmTHV2FPT0WU
PANC-10-05 NGXiXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzuTWM2OD12MD6xPFI5KM7:TR?= M13ue3NCVkeHUh?=
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RPMI-7951 M2S5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\GR2lEPTB;NEGuNlA4PSEQvF2= NFjieo1USU6JRWK=
BB49-HNC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2C0TmlEPTB;NEGuNlE4QSEQvF2= NGnLdmpUSU6JRWK=
23132-87 MkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTRzLkK3N|Ih|ryP M3[4PXNCVkeHUh?=
HCC1569 NH3PbWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLxT3BKSzVyPUSxMlI5QDVizszN MUPTRW5ITVJ?
CP66-MEL MoLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3rU2VKSzVyPUSyMlE5QDZizszN M2PGd3NCVkeHUh?=
K-562 NFvuXVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH76TllKSzVyPUSyMlI5PTRizszN Mlr4V2FPT0WU
OCI-AML2 MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTR{Lki5O|Qh|ryP NGXvdlhUSU6JRWK=
SW756 MknqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfjXG9PUUN3ME20N{4xOzh6IN88US=> M2C4XnNCVkeHUh?=
M14 M4XVNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTR|LkOxPFkh|ryP NHrmRWtUSU6JRWK=
NCI-H1623 NILkT3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2D0ZmlEPTB;NEOuOFY1KM7:TR?= MYnTRW5ITVJ?
KNS-81-FD M{L0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWqydYZXUUN3ME20N{44PjJizszN MWPTRW5ITVJ?
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RERF-LC-MS NVyyOpJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHLbm5UUUN3ME20N{46OjhzIN88US=> M1P6TXNCVkeHUh?=
PC-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1z5dmlEPTB;NESuOFM1PyEQvF2= NHv3b3VUSU6JRWK=
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NCI-H510A MmLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3QWGpoUUN3ME20OE44ODhizszN M2\MbXNCVkeHUh?=
LB2518-MEL Mn3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTR2Lke5N|ch|ryP MYnTRW5ITVJ?
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EW-24 Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;qSmlEPTB;NE[uNVczOyEQvF2= MXLTRW5ITVJ?
LB647-SCLC M1[3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTR4LkKxOVUh|ryP MoG0V2FPT0WU
NCI-H524 NFLDdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETPe4lKSzVyPUS2MlcyQDVizszN NXrRbG41W0GQR1XS
EW-11 Ml36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTabWtZUUN3ME20Ok46Ozd|IN88US=> NUDlO5A1W0GQR1XS
KALS-1 Ml63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnxOpVKSzVyPUS3MlIxPjZizszN Mki4V2FPT0WU
BT-474 NULIeY5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[xVZlKSzVyPUS3MlQzOTZizszN NWLKc5NsW0GQR1XS
SK-N-AS Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTR5Lki4PEDPxE1? MVPTRW5ITVJ?
HCC2157 NHfIV4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTR6LkC3OkDPxE1? NXPlbo8xW0GQR1XS
HCC1954 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTvTWM2OD12OD6xO|A1KM7:TR?= NXjqTYdMW0GQR1XS
FADU NEe1NFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnDbINKSzVyPUS4MlMxOzFizszN NVP2RmpyW0GQR1XS
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LS-1034 M2XGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[5OHJPUUN3ME20PE44ODZ5IN88US=> MUnTRW5ITVJ?
CAMA-1 NXjQSYFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3T4XmlEPTB;NEmuOVU1OyEQvF2= MVvTRW5ITVJ?
LU-134-A M2jSXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ztO2lEPTB;NEmuPFA5PSEQvF2= M2DTSXNCVkeHUh?=
NCI-H1838 M{POUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTzTWM2OD12OT64NFg4KM7:TR?= NVf1V2dFW0GQR1XS

... Click to View More Cell Line Experimental Data

体内研究 Ponatinib抑制取自FLT3-ITD阳性AML病人的原代白血病细胞,而不抑制表达阴性FLT3的AML病人的白血病细胞。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
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激酶实验:

通过同质时间分辨荧光共振能量转移法(TR-FRET),使用纯化的人类野生型ABL激酶,T315I突变型ABL激酶,及生物素化的磷酸激酶底物肽: 生物素-EKKMAAEAIYAAPFAK-NH2,测定野生型ABL和T315I突变型ABL活性的抑制激酶反应在全LANCE激酶buffer (LKB)中进行,LKB包括20 mM NaHEPES(pH 为7.4), 0.1 mg ⁄ mL BSA, 1 mM ATP, 10 mM MgCl2, 及0.41 mM DTT,在提前用1% BSA(溶于PBS)包被的96孔板上4oC下过夜。用于激酶反应,Ponatinib稀释物和野生型ABL, T315I突变型ABL (40 pM), 及底物肽(50 nM), 在室温下温育1小时(T315I突变型ABL)或2小时(野生型ABL)。加入15 nM 抑制剂, 6 nM 铕标记的磷酸酪氨酸抗体(磷酸化位点在第66为酪氨酸上),及60 nM 别藻蓝素标记的链酶亲和素,终止反应。实验板在室温下黑暗温育20分钟,使用Wallac Victor2V读数器读取615和665nm处的荧光值。在孔中数据平均值中插入抑制剂的3倍连续稀释液,再读取665nm处荧光值,计算IC50值。
细胞实验:[1]
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  • Cell lines: Ba ⁄ F3细胞
  • Concentrations: 0-625 nM, 和0-10 µM
  • Incubation Time: 72小时
  • Method: Ba/F3细胞系按每孔4×103个细胞分布在96孔板上(4×103),和梯度浓度Ponatinib温育72小时。Ponatinib浓度范围为: 0-625 nM 作用于表达BCR-ABL细胞,0-10 µM 用于测定BCR-ABL阴性细胞。使用MTS实验测定细胞增殖,取三次平行实验平均值测定IC50值。
    (Only for Reference)
动物实验:[3]
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  • Animal Models: 皮下植入MV4-11细胞移植瘤(1×107,50%基质胶中) 的雌性CB.17 SCID鼠
  • Formulation: 25 mmol/L柠檬酸盐缓冲液(pH 为2.75)
  • Dosages: 每天处理一次,持续4周
  • Administration: 口服饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
1% CMC Na
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 532.56
化学式

C29H27F3N6O

CAS号 943319-70-8
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID