Ponatinib (AP24534)

目录号:S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。

规格 价格 库存 购买数量  
RMB 819.31 现货
RMB 903.01 现货
RMB 3034.48 现货
RMB 7959.08 现货
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客户使用该产品的4个实验数据:

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017. Ponatinib (AP24534) purchased from Selleck.

产品安全说明书

Bcr-Abl抑制剂选择性比较

生物活性

产品描述 Ponatinib (AP24534)是一种新型有效的多靶点抑制剂,在无细胞试验中作用于Abl,PDGFRα,VEGFR2,FGFR1和Src,IC50分别为0.37 nM,1.1 nM,1.5 nM,2.2 nM和5.4 nM。
靶点
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
体外研究

Ponatinib是有效的可用于口服的多靶点激酶抑制剂,作用于野生型细胞,及T315I 突变细胞IC50分别为1.2和8.8nM。[1] Ponatinib抑制Ba/F3衍生细胞系的增殖。[2] Ponatinib作用于表达野生型或T315I突变型BCR-ABL的CML细胞系,有效抑制BCR-ABL调节的信号。Ponatinib阻断在细胞瘤筛选时产生抗性突变。[3] Ponatinib也抑制VEGFR和FGFR家族激酶,在体外抑制FLT3, KIT, FGFR1,和PDGFRa激酶活性时IC50分别为13, 13, 2, 和1 nM.[4]Ponatinib抑制全部4种RTKs磷酸化,存在剂量依赖性,IC50值为0.3到20 nM。然而,Ponatinib抑制表达野生型FLT3的RS4;11细胞时IC50>100 nM。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell M{\ESmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfrSW9KSzVyPUCuNFAxODByMEO1PUDPxE1? MUjTRW5ITVJ?
MV-4-11 NV2xZ|ZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMECwNFk2PiEQvF2= MmXtV2FPT0WU
MEG-01 NHP0UldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMECwNVI5KM7:TR?= NYL1TXA3W0GQR1XS
LAMA-84 Mom2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMECwNVY2KM7:TR?= NX7TOYxnW0GQR1XS
CGTH-W-1 Mn;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT4TWM2OD1yLkCwNVY6KM7:TR?= M{XVXHNCVkeHUh?=
KASUMI-1 NW\YWXZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnETWM2OD1yLkCwNlE4KM7:TR?= NVnp[o9JW0GQR1XS
BE-13 M{HaZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMECyOVkh|ryP MnzOV2FPT0WU
CTV-1 MmG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3STWM2OD1yLkCwOVIyKM7:TR?= MlLqV2FPT0WU
NKM-1 Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEC2OVUh|ryP NVG0O4lqW0GQR1XS
MONO-MAC-6 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TlRWlEPTB;MD6wNFg{PyEQvF2= MUfTRW5ITVJ?
A204 NH[yRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fLUGlEPTB;MD6wNVIyQCEQvF2= NIn1ZotUSU6JRWK=
GDM-1 M4nlbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfPTWM2OD1yLkCxPFM{KM7:TR?= NH3iUnFUSU6JRWK=
AN3-CA NXLLdmJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWC4U3dKUUN3ME2wMlAyQDd|IN88US=> M1P1SXNCVkeHUh?=
BL-70 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVL1N3NUUUN3ME2wMlAzOTl7IN88US=> MX;TRW5ITVJ?
Daudi Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHOTWM2OD1yLkCyOVM4KM7:TR?= Mo\sV2FPT0WU
KU812 NWrkRnE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;5RmlEPTB;MD6wNlg1QCEQvF2= MUPTRW5ITVJ?
KG-1 NIjB[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTpU2liUUN3ME2wMlA{Ojl2IN88US=> MVLTRW5ITVJ?
DOHH-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7qTWM2OD1yLkC0PFA{KM7:TR?= M2e5VHNCVkeHUh?=
HuO9 NX35T|ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGGyVppKSzVyPUCuNFU1PDhizszN M1PmeHNCVkeHUh?=
EB2 MlPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjSZ5REUUN3ME2wMlA2PTd4IN88US=> M1nWeHNCVkeHUh?=
G-402 M4DJOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfFZnNKSzVyPUCuNFY{PDFizszN NXzVU4p7W0GQR1XS
SU-DHL-1 MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrRVG1KSzVyPUCuNFY{PzlizszN NHvhOZlUSU6JRWK=
NCI-H719 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoroTWM2OD1yLkC3PFg5KM7:TR?= NI\XfYRUSU6JRWK=
MLMA MlTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrUOFdkUUN3ME2wMlA6ODZizszN NFq1[FBUSU6JRWK=
KM12 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jDSWlEPTB;MD6wPVc{PyEQvF2= MXPTRW5ITVJ?
SUP-T1 M3T3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLpTWM2OD1yLkC5PVgzKM7:TR?= NID0WI1USU6JRWK=
MZ1-PC NIqwO3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\1[phKSzVyPUCuNVE{OzZizszN NXvvUpMyW0GQR1XS
MFE-296 MmqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\wTWM2OD1yLkGxPFM6KM7:TR?= M{Hz[nNCVkeHUh?=
ALL-PO NYDNbFc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7qXFAyUUN3ME2wMlEzPDR|IN88US=> M2XZR3NCVkeHUh?=
GB-1 NHLHeXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXJTWM2OD1yLkGyOVEzKM7:TR?= NYfQenZqW0GQR1XS
SIG-M5 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rp[GlEPTB;MD6xN|M4KM7:TR?= MY\TRW5ITVJ?
P30-OHK Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEj3VnVKSzVyPUCuNVU3PzJizszN MnzLV2FPT0WU
NCI-H716 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrCTWM2OD1yLkG2NlY3KM7:TR?= Mn35V2FPT0WU
MPP-89 NILleYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fJbWlEPTB;MD6xOlk{OyEQvF2= MVnTRW5ITVJ?
SF126 NXfTe3dST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjPTWM2OD1yLkG3NFY{KM7:TR?= M{LjcXNCVkeHUh?=
CTB-1 NWn5eWxET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPFU3NKSzVyPUCuNVc{OTZizszN MWHTRW5ITVJ?
CA46 MnXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S1b2lEPTB;MD6xO|Q5QSEQvF2= MWLTRW5ITVJ?
NCI-H520 NXTlW4NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXNdYdKSzVyPUCuNVc4OzJizszN M{XyTnNCVkeHUh?=
CAL-85-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvlXJhTUUN3ME2wMlE4QTJ5IN88US=> NX64Oph4W0GQR1XS
NCI-H2342 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMUi1O|ch|ryP M1zVOXNCVkeHUh?=
697 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjWXmhYUUN3ME2wMlE5QDdzIN88US=> MVXTRW5ITVJ?
NY NGfnU3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1v2dWlEPTB;MD6xPVI5PyEQvF2= NHf3XIZUSU6JRWK=
T98G M1TIfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPuTWM2OD1yLkG5N|E5KM7:TR?= Mn\aV2FPT0WU
NCI-H1703 MlrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHm3OHFKSzVyPUCuNVk3OTVizszN NEm2fYdUSU6JRWK=
NCI-H2087 NWfzU4JGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\O[JpKSzVyPUCuNlA1OzlizszN MX\TRW5ITVJ?
PF-382 NVnYWW85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMkC4O|Mh|ryP M1f1ZXNCVkeHUh?=
HCT-116 NFzET2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;FWJg2UUN3ME2wMlIyODZ7IN88US=> Mlv1V2FPT0WU
CAKI-1 NH7zVZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljtTWM2OD1yLkKxOlY3KM7:TR?= NELrdGFUSU6JRWK=
CCF-STTG1 NGf2UIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXZTWM2OD1yLkKyOFc2KM7:TR?= NF7GdJZUSU6JRWK=
D-392MG MnzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rqbGlEPTB;MD6yN|E4PyEQvF2= NU\xe4gzW0GQR1XS
RT-112 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnpdY5oUUN3ME2wMlI{Pzl3IN88US=> Mk\mV2FPT0WU
MES-SA NV7jcnFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHWfZRKSzVyPUCuNlQyQDdizszN MUHTRW5ITVJ?
LC-2-ad MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTlSIxNUUN3ME2wMlI1OjZ3IN88US=> NV3LWVNNW0GQR1XS
NOS-1 M3nobWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnr6TWM2OD1yLkK0N|Y4KM7:TR?= MX\TRW5ITVJ?
NALM-6 NGH2[IdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInXUoxKSzVyPUCuNlU2PDNizszN M2DUTnNCVkeHUh?=
TE-15 MkHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M174UWlEPTB;MD6yOlA6OSEQvF2= NG\1[3dUSU6JRWK=
786-0 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;oPGlEPTB;MD6yOlIzQCEQvF2= NEiyWnlUSU6JRWK=
IST-MES1 M{OxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnJTWM2OD1yLkK2PFI6KM7:TR?= MUTTRW5ITVJ?
KYSE-180 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfsTWM2OD1yLkK2PFkyKM7:TR?= M{ftZnNCVkeHUh?=
YT MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3W5UGlEPTB;MD6yOlk4PCEQvF2= Mlr3V2FPT0WU
A427 M3;EVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMkeyOlQh|ryP Mn7YV2FPT0WU
KYSE-450 M1K3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrsXnNKSzVyPUCuNlc{OjlizszN NWXRN5VKW0GQR1XS
HuH-7 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHmU|JKSzVyPUCuNlc4PjNizszN MWDTRW5ITVJ?
CAS-1 NUWx[3E1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;FXI9oUUN3ME2wMlI5OzB|IN88US=> NIn5c5NUSU6JRWK=
KURAMOCHI NWTEcmFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMki0NVkh|ryP MVjTRW5ITVJ?
ACHN MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfvOYtlUUN3ME2wMlI6OzJ|IN88US=> NIXiXHRUSU6JRWK=
HGC-27 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3sOXBKSzVyPUCuNlk{PTNizszN M4\LUHNCVkeHUh?=
A172 NFu2[pFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHIS|VKSzVyPUCuNlk2PzdizszN MUTTRW5ITVJ?
SNU-449 MlX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PFWmlEPTB;MD6yPVk3PCEQvF2= MoO4V2FPT0WU
SW982 M17iNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonJTWM2OD1yLkK5PVc5KM7:TR?= NXrTOpVnW0GQR1XS
EFO-21 NUC3elJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH73TYVKSzVyPUCuN|A1OTFizszN M{XRZ3NCVkeHUh?=
NCI-H2030 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4SwNWlEPTB;MD6zNVE3PCEQvF2= NUnnW3VYW0GQR1XS
HT-144 MonSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXkeHlrUUN3ME2wMlMyOjhizszN NUn4Z|JDW0GQR1XS
MFE-280 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwM{G0OVMh|ryP MknyV2FPT0WU
SK-LU-1 NH;sZ5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLKTWM2OD1yLkOxOFY3KM7:TR?= NVflXpZsW0GQR1XS
NCI-H2052 M2TzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfLOpNKSzVyPUCuN|E1QDRizszN Mk\BV2FPT0WU
SK-HEP-1 NXv5dI9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwM{OzOlgh|ryP NYLFbGxLW0GQR1XS
QIMR-WIL NU\YW3N{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7wbWtKSzVyPUCuN|M1OjRizszN NX73cnRNW0GQR1XS
A2780 NH7yRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXzSoRKSzVyPUCuN|Q{ODRizszN NHvOfGJUSU6JRWK=
ACN NFnJWYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrQeplKSzVyPUCuN|Q5PzNizszN MUPTRW5ITVJ?
BxPC-3 NX\vbYc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInRU4ZKSzVyPUCuN|Q6QDlizszN NHHMUnhUSU6JRWK=
BCPAP M1\4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkT2TWM2OD1yLkO2NFAyKM7:TR?= NFjFR2ZUSU6JRWK=
HOP-62 NYjmbotJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLLTWM2OD1yLkO2NVA3KM7:TR?= M1nz[HNCVkeHUh?=
SW1710 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1OwU2lEPTB;MD6zOlQ2PSEQvF2= MmXKV2FPT0WU
OPM-2 M2q2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDOTWM2OD1yLkO2OFc{KM7:TR?= MmfJV2FPT0WU
DBTRG-05MG NVHUTlNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwM{iwOVQh|ryP M3nKVHNCVkeHUh?=
SK-MEL-24 NV\Te5lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwM{m3PVEh|ryP NFTHS|FUSU6JRWK=
8305C Ml\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTFUWhWUUN3ME2wMlM6Pzl|IN88US=> NHHWZmNUSU6JRWK=
OVCAR-4 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7ETWM2OD1yLkSxOVg3KM7:TR?= MWTTRW5ITVJ?
HLE NFuy[WtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwNEG4OkDPxE1? MXvTRW5ITVJ?
NCI-H747 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;aPJdKSzVyPUCuOFIyOzdizszN MoKyV2FPT0WU
SW780 NITvVnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml2zTWM2OD1yLkSyN|Q3KM7:TR?= NVuyPWlIW0GQR1XS
KYSE-150 NWrwRndGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwNEK0NVUh|ryP NVLvUnBwW0GQR1XS
H4 M1zUW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrNXVRKSzVyPUCuOFI1PTFizszN NF\XdIRUSU6JRWK=
SW1088 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjPWoRKSzVyPUCuOFQ{QSEQvF2= NXvz[od7W0GQR1XS
SF268 M1X4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLoTWM2OD1yLkS0PFYh|ryP M1LpRXNCVkeHUh?=
RT4 NGrYOHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwNEWxNVEh|ryP MX7TRW5ITVJ?
NCI-H522 NF;Mc|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jwc2lEPTB;MD60OVI4KM7:TR?= M2PYPHNCVkeHUh?=
LCLC-97TM1 NX7wZoZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnwTWM2OD1yLkS2NVk2KM7:TR?= Mn\UV2FPT0WU
CAL-39 NXjWXXV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fGSmlEPTB;MD60OlUyQSEQvF2= MYjTRW5ITVJ?
CAL-120 NX3SfYRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH6WGJbUUN3ME2wMlQ4PjR|IN88US=> NUO3[WFKW0GQR1XS
ESS-1 NEnrT4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwNEe4NlEh|ryP NVXtfldOW0GQR1XS
KARPAS-45 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7zTWM2OD1yLkS4PVM{KM7:TR?= NIS0SWdUSU6JRWK=
DU-4475 M2\Pb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwNEm1NVEh|ryP MUHTRW5ITVJ?
VMRC-RCZ Mn:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITmUIFKSzVyPUCuOFk6ODRizszN NV7mcVgyW0GQR1XS
HOS NVPVcXI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwNUCzOlUh|ryP M37R[HNCVkeHUh?=
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D-542MG NX3iZWt1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjvSnl3UUN3ME2xMlg2QDVzIN88US=> M4PQZXNCVkeHUh?=
KNS-42 NFnlW3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFwOE[yOlYh|ryP NXK0coZuW0GQR1XS
NCI-H2452 NFHlZm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTFwOEmwO|Qh|ryP NGflVnNUSU6JRWK=
SK-MEL-2 M3PjSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFztTGJKSzVyPUGuPVAzPzFizszN MWDTRW5ITVJ?
OVCAR-5 NVHVZnNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\VU3JKSzVyPUGuPVA3PzVizszN MU\TRW5ITVJ?
SNG-M NYSweFB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTFwOUW4OVgh|ryP M3TwU3NCVkeHUh?=
A673 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXPTWM2OD1zLkm3OVE3KM7:TR?= M{HJfXNCVkeHUh?=
L-428 NEC1O4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmmzTWM2OD1zLkm5NVc6KM7:TR?= M2j1VnNCVkeHUh?=
KM-H2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwMEGwPUDPxE1? MkLqV2FPT0WU
MC-IXC M4n1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJwMEKyO|Mh|ryP NVHn[VB7W0GQR1XS
COLO-678 MlzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXyS4Z2UUN3ME2yMlA1OjB5IN88US=> M4G3PHNCVkeHUh?=
MEL-JUSO MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnPSno6UUN3ME2yMlA4QDVzIN88US=> NGPQcGVUSU6JRWK=
HCC38 Mmq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrON2VOUUN3ME2yMlA5PDN|IN88US=> M1qxdnNCVkeHUh?=
UACC-62 NYPuU283T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTNV2VFUUN3ME2yMlA5QDV3IN88US=> MoKzV2FPT0WU
OAW-42 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnwTWM2OD1{LkC5O|EyKM7:TR?= NXXtb|d3W0GQR1XS
LB996-RCC NW\KXW5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT3SmxIUUN3ME2yMlE{QDF5IN88US=> NHXTVWJUSU6JRWK=
COR-L105 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjjNJdKSzVyPUKuNVY{PzNizszN NU\HXm9FW0GQR1XS
RCC10RGB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rTNGlEPTB;Mj6xPFU4PiEQvF2= NU\J[oJwW0GQR1XS
A431 NGrVbJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJwMUmwNVkh|ryP MYXTRW5ITVJ?
NCI-H292 NV3vS29MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\iUGlEPTB;Mj6yN|k2OSEQvF2= NXW5ZY16W0GQR1XS
SK-UT-1 M4PJfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJwM{OxPFQh|ryP Mn7zV2FPT0WU
PANC-08-13 NYTvcVg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrtTWM2OD1{LkOzNlM2KM7:TR?= NIKwXXpUSU6JRWK=
ST486 MoXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJwNEGwOFgh|ryP MnSwV2FPT0WU
SJSA-1 M3LWfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mle5TWM2OD1{LkSxNlcyKM7:TR?= MoLDV2FPT0WU
RKO NIK3O4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHqzNXlKSzVyPUKuOFIxOjlizszN Mn20V2FPT0WU
NCI-H1793 NUTEZ3VuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlKyTWM2OD1{LkS0NFI6KM7:TR?= M1z1TnNCVkeHUh?=
639-V MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzwTWM2OD1{LkS1N|gzKM7:TR?= M1yzTXNCVkeHUh?=
ES3 M2G2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jMVGlEPTB;Mj60PVc{PyEQvF2= NECxXZdUSU6JRWK=
NCI-H1792 NIW2O|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTJwNU[4NlYh|ryP NIHLPJZUSU6JRWK=
NCI-H1651 M4LONGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PK[GlEPTB;Mj61PFIyKM7:TR?= MVXTRW5ITVJ?
SN12C NIW0e5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTJwNUi0PFch|ryP NEDuZnRUSU6JRWK=
COLO-679 NXryVW1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXET2dKSzVyPUKuOVg3ODVizszN NXy5VmxoW0GQR1XS
U-118-MG MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDoTWM2OD1{LkW4PFczKM7:TR?= NHTncYVUSU6JRWK=
Ramos-2G6-4C10 MmO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rjUWlEPTB;Mj62OFgxPyEQvF2= M2\l[nNCVkeHUh?=
HCT-15 NEmxfopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHqwV5FKSzVyPUKuOlg4QTJizszN MmTKV2FPT0WU
MDA-MB-157 M{ixTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7DPZlVUUN3ME2yMlcxPzR5IN88US=> MmTuV2FPT0WU
K5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fLNGlEPTB;Mj63NVg1PSEQvF2= NWjwcJVwW0GQR1XS
MKN45 NXn3Nnp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fKZmlEPTB;Mj63N|M3PiEQvF2= M1;lb3NCVkeHUh?=
DMS-273 NHSy[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS3TWM2OD1{Lke1OlMzKM7:TR?= MVLTRW5ITVJ?
C8166 NXfCenAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPkTopCUUN3ME2yMlc5PTF|IN88US=> MXHTRW5ITVJ?
Calu-3 NHL0XnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnrXHZKSzVyPUKuO|g6PjlizszN Ml7jV2FPT0WU
SNB75 NEnqc|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmwZ4FXUUN3ME2yMlg5PTN3IN88US=> M33WPHNCVkeHUh?=
BFTC-905 NFXGOm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPSZmhsUUN3ME2yMlkxOTlzIN88US=> M1LoZ3NCVkeHUh?=
C-4-II NFfvVIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TPRmlEPTB;Mj65NVM2OyEQvF2= MnLQV2FPT0WU
MS-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrJTWM2OD1{Lkm2O|Y6KM7:TR?= NGHFT41USU6JRWK=
A375 NH3zXo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HS[mlEPTB;Mz6wPFE5PCEQvF2= MXTTRW5ITVJ?
KYSE-70 NVXydpNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrCO5B7UUN3ME2zMlA5QDh{IN88US=> NFzjPGFUSU6JRWK=
KYSE-510 M{m3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PkbmlEPTB;Mz6xNFk6PSEQvF2= M4nNN3NCVkeHUh?=
LN-405 Ml\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTNwMUO1NVgh|ryP NX3EfZNNW0GQR1XS
BOKU MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHKZWtKSzVyPUOuNVQzPTZizszN M3XnN3NCVkeHUh?=
TE-10 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4P0e2lEPTB;Mz6xO|M3OiEQvF2= MUnTRW5ITVJ?
MKN1 NHH0NIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTNwMUi0PFMh|ryP MknZV2FPT0WU
M059J NH3sd5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTNwMkCxO|Mh|ryP MWDTRW5ITVJ?
GOTO NUW0SnNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;JXGhKSzVyPUOuNlIxOzlizszN NIHPVmdUSU6JRWK=
DK-MG MlHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTNwMkW5O|Yh|ryP MkfOV2FPT0WU
NCI-H727 MoTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{WyNGlEPTB;Mz6yOlU5KM7:TR?= M4D4VnNCVkeHUh?=
NB12 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;XWmlEPTB;Mz6zN|IzPCEQvF2= M4XlRXNCVkeHUh?=
DOK MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTZTWM2OD1|LkO2NVg3KM7:TR?= MVTTRW5ITVJ?
KYSE-410 MoLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK2SlFyUUN3ME2zMlM3Ojh5IN88US=> MXnTRW5ITVJ?
AM-38 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn63TWM2OD1|LkO4NFUyKM7:TR?= M4D0O3NCVkeHUh?=
GR-ST MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\5NYpKSzVyPUOuOFU4OzJizszN M17KZnNCVkeHUh?=
D-247MG MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTUcWdKSzVyPUOuOFgzPjNizszN NF;YbGZUSU6JRWK=
TE-8 MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTNwNEmzN|Mh|ryP M3PQOHNCVkeHUh?=
LS-411N NXfRTlRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnINJBKSzVyPUOuOFk3QTJizszN MWLTRW5ITVJ?
SK-MES-1 NX\DXXVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTNwNU[0N|Mh|ryP MV7TRW5ITVJ?
SF295 M3\pcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;hZWlEPTB;Mz62NVU2OiEQvF2= MYHTRW5ITVJ?
SK-MEL-30 M2Ph[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDqTWM2OD1|Lk[1PVIyKM7:TR?= NVzYXJREW0GQR1XS
LB2241-RCC NHvacJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;6TWM2OD1|Lk[2NlYh|ryP Mli3V2FPT0WU
PC-14 Ml;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HE[mlEPTB;Mz62OlQ{PyEQvF2= NXi3clFGW0GQR1XS
EW-7 Mlz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPaU4VKSzVyPUOuOlc3QTNizszN NHrEUGFUSU6JRWK=
NMC-G1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL1NIw4UUN3ME2zMlcyQDN5IN88US=> MknQV2FPT0WU
TE-441-T NUfzV5k5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{H2[WlEPTB;Mz63N|AzQCEQvF2= NVjDRnJFW0GQR1XS
NCI-H1618 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrITWM2OD1|LkixPFc2KM7:TR?= NVHXR2ZZW0GQR1XS
PANC-03-27 MlO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;5OXFtUUN3ME2zMlgyQTF4IN88US=> M3GwWnNCVkeHUh?=
NCI-H2228 Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\P[2lEPTB;Mz64N|EzPiEQvF2= NE\qdJZUSU6JRWK=
CAPAN-1 MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\LPWlEPTB;Mz64O|AxQSEQvF2= MkH2V2FPT0WU
KLE MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;3fnZoUUN3ME2zMlkxPjdizszN NV;HUllZW0GQR1XS
Becker NIDhboFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml2wTWM2OD1|LkmyPFQ6KM7:TR?= MXXTRW5ITVJ?
SK-PN-DW MojES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLxTWM2OD12LkC3PVc1KM7:TR?= MXrTRW5ITVJ?
Hs-578-T NYLxTXhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTRwMEizNFYh|ryP MYLTRW5ITVJ?
RS4-11 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX72W5JlUUN3ME20MlEyOjV3IN88US=> MVrTRW5ITVJ?
D-502MG M{nIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXoeGpKSzVyPUSuNVY6QTdizszN Ml\JV2FPT0WU
GI-1 NWXkSZBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\lSJh[UUN3ME20MlI5Ojl7IN88US=> M{iyTnNCVkeHUh?=
NCI-H209 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYj3V3dIUUN3ME20MlM{PzhizszN NWD0OJZqW0GQR1XS
SK-OV-3 NGTCSpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITzOWZKSzVyPUSuOFgyPDlizszN MYLTRW5ITVJ?
LOUCY MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\pTWM2OD12LkS4OFMzKM7:TR?= M3rHV3NCVkeHUh?=
NCI-H69 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTRwNUG3PVMh|ryP MkTuV2FPT0WU
SCC-9 M1TRXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G4[2lEPTB;ND61N|E4OiEQvF2= NV7LU3JsW0GQR1XS
NCI-H526 NGTNN5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLNTWM2OD12LkW5Nlk{KM7:TR?= NWfPUYpEW0GQR1XS
NCI-H2170 NETrb4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLWXGV2UUN3ME20MlY3PzdzIN88US=> M4faT3NCVkeHUh?=
SR Mnj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTRwN{CwOFgh|ryP NIDhPXpUSU6JRWK=
CMK M{XtUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jZZmlEPTB;ND63NlExOSEQvF2= MV7TRW5ITVJ?
COLO-829 Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[0TGlEPTB;ND63O|A1OyEQvF2= Ml;iV2FPT0WU
HuO-3N1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF76VVJKSzVyPUSuPFMzQDFizszN MormV2FPT0WU
5637 NEHTcY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTRwOUC0PFch|ryP MWjTRW5ITVJ?
A253 NYPlWWlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUS5NoxmUUN3ME20Mlk4PzB6IN88US=> M{m3[XNCVkeHUh?=
NB10 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWGydYF5UUN3ME21MlA4PDl5IN88US=> NFfKdGVUSU6JRWK=
SF539 NGHEfFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD0TWM2OD13LkC5PVU6KM7:TR?= Mn;OV2FPT0WU
HAL-01 NW\6eGJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjOOnVKSzVyPUWuNVQ3PDVizszN M33Xb3NCVkeHUh?=
MHH-ES-1 NVfVcZZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rmOmlEPTB;NT6xOlkzPSEQvF2= NHHNd5RUSU6JRWK=
DEL MkDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrFZVFKSzVyPUWuNlc2QDJizszN NIXXZo9USU6JRWK=
NCI-H1299 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;UWo5KSzVyPUWuN|UxODdizszN MVrTRW5ITVJ?
ChaGo-K-1 M2Swemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvySW9KSzVyPUWuN|UyODdizszN MWHTRW5ITVJ?
HMV-II NHnu[nRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTVwM{m0N{DPxE1? NELhfIxUSU6JRWK=
NB69 NV;kOVBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;1TWM2OD13LkO5OlMyKM7:TR?= NXzRXWY3W0GQR1XS
NCI-H1882 M2fsZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPhenpRUUN3ME21MlQ{OzZ2IN88US=> NHO0WIFUSU6JRWK=
SNU-475 NVLjdVlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrONoRzUUN3ME21MlQ4OTdzIN88US=> NF61cm1USU6JRWK=
RXF393 NHW0W45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP6TWM2OD13LkS4OFk1KM7:TR?= NEHmZ4NUSU6JRWK=
CAL-51 M1\RSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTVwNkK4OVMh|ryP M{K2d3NCVkeHUh?=
SW1573 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTVwNkO1N|Qh|ryP MWrTRW5ITVJ?
GCT NF[4TGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4S4R2lEPTB;NT63OVkzQSEQvF2= M4jZeXNCVkeHUh?=
COR-L88 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTmd4JoUUN3ME21Mlc3QDR4IN88US=> MUnTRW5ITVJ?
MDA-MB-134-VI MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rENmlEPTB;NT64O|U{PiEQvF2= NHO1N3JUSU6JRWK=
NB5 NYmxRXYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mly5TWM2OD13LkmyOFQh|ryP M1nobnNCVkeHUh?=
GMS-10 NV;CPJdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVKwTJNYUUN3ME21Mlk3QDZzIN88US=> NFHlbZNUSU6JRWK=
CHP-212 NEfQeHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTZwNEiyOlch|ryP MXLTRW5ITVJ?
TE-11 NYToN5UzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULoVmpIUUN3ME22MlU2OTh{IN88US=> NE\kUmNUSU6JRWK=
SW962 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;yeYx4UUN3ME22MlY2Pzd2IN88US=> M3\zU3NCVkeHUh?=
MZ2-MEL NELkRpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPwTWM2OD14LkiyNFEyKM7:TR?= NHzobJdUSU6JRWK=
C-33-A MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7QTWM2OD14LkmxOlg5KM7:TR?= M4DqZnNCVkeHUh?=
IGR-1 M3\EbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTZwOUe4NlYh|ryP MUTTRW5ITVJ?
MOLT-4 NFz2N2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTdwMUW0NFYh|ryP NYfGbHF6W0GQR1XS
NCI-H1650 Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fZVGlEPTB;Nz6yO|A1PiEQvF2= MlriV2FPT0WU
AsPC-1 MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Po[2lEPTB;Nz6yPFYxPSEQvF2= Mn;2V2FPT0WU
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NCI-H661 NHvOS4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTN{Lk[1NFEh|ryP MlHyV2FPT0WU
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NCI-H596 Mn\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\JT5VKUUN3ME2zPE41PDh7IN88US=> NFPyUHVUSU6JRWK=
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PANC-10-05 M1XxW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXyXXg4UUN3ME20NE4yQDJ6IN88US=> NFOwOWZUSU6JRWK=
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23132-87 MnrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTxZol1UUN3ME20NU4zPzN{IN88US=> NVjrcHJHW0GQR1XS
HCC1569 NYn5W5R3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTZWYZTUUN3ME20NU4zQDh3IN88US=> MkDaV2FPT0WU
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K-562 M4TITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3OxdWlEPTB;NEKuNlg2PCEQvF2= MmmyV2FPT0WU
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BT-474 NV7lZ5dRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHO[lRxUUN3ME20O{41OjF4IN88US=> MWTTRW5ITVJ?
SK-N-AS NXO3dnJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jXbmlEPTB;NEeuPFg5KM7:TR?= MV\TRW5ITVJ?
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LS-1034 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fyOWlEPTB;NEiuO|A3PyEQvF2= MoGyV2FPT0WU
CAMA-1 NEL0NnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXlblBKSzVyPUS5MlU2PDNizszN Ml;iV2FPT0WU
LU-134-A MoC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTR7LkiwPFUh|ryP MU\TRW5ITVJ?
NCI-H1838 NFrOWFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTsWXVFUUN3ME20PU45ODh5IN88US=> MXPTRW5ITVJ?

... Click to View More Cell Line Experimental Data

体内研究 Ponatinib抑制取自FLT3-ITD阳性AML病人的原代白血病细胞,而不抑制表达阴性FLT3的AML病人的白血病细胞。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

激酶实验:

通过同质时间分辨荧光共振能量转移法(TR-FRET),使用纯化的人类野生型ABL激酶,T315I突变型ABL激酶,及生物素化的磷酸激酶底物肽: 生物素-EKKMAAEAIYAAPFAK-NH2,测定野生型ABL和T315I突变型ABL活性的抑制激酶反应在全LANCE激酶buffer (LKB)中进行,LKB包括20 mM NaHEPES(pH 为7.4), 0.1 mg ⁄ mL BSA, 1 mM ATP, 10 mM MgCl2, 及0.41 mM DTT,在提前用1% BSA(溶于PBS)包被的96孔板上4oC下过夜。用于激酶反应,Ponatinib稀释物和野生型ABL, T315I突变型ABL (40 pM), 及底物肽(50 nM), 在室温下温育1小时(T315I突变型ABL)或2小时(野生型ABL)。加入15 nM 抑制剂, 6 nM 铕标记的磷酸酪氨酸抗体(磷酸化位点在第66为酪氨酸上),及60 nM 别藻蓝素标记的链酶亲和素,终止反应。实验板在室温下黑暗温育20分钟,使用Wallac Victor2V读数器读取615和665nm处的荧光值。在孔中数据平均值中插入抑制剂的3倍连续稀释液,再读取665nm处荧光值,计算IC50值。
细胞实验:[1]
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  • Cell lines: Ba ⁄ F3细胞
  • Concentrations: 0-625 nM, 和0-10 µM
  • Incubation Time: 72小时
  • Method: Ba/F3细胞系按每孔4×103个细胞分布在96孔板上(4×103),和梯度浓度Ponatinib温育72小时。Ponatinib浓度范围为: 0-625 nM 作用于表达BCR-ABL细胞,0-10 µM 用于测定BCR-ABL阴性细胞。使用MTS实验测定细胞增殖,取三次平行实验平均值测定IC50值。
    (Only for Reference)
动物实验:[3]
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  • Animal Models: 皮下植入MV4-11细胞移植瘤(1×107,50%基质胶中) 的雌性CB.17 SCID鼠
  • Formulation: 25 mmol/L柠檬酸盐缓冲液(pH 为2.75)
  • Dosages: 每天处理一次,持续4周
  • Administration: 口服饲喂处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
1% CMC Na
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 532.56
化学式

C29H27F3N6O

CAS号 943319-70-8
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02829840 Not yet recruiting Leukemia|FLT3-Mutated Acute Myeloid Leukemia|FLT3-Mutated High-Risk Myelodysplastic Syndrome M.D. Anderson Cancer Center|Ariad Pharmaceuticals September 2016 Phase 1|Phase 2
NCT02398825 Recruiting Chronic Myeloid Leukemia|Chronic Phase|Adults Gruppo Italiano Malattie EMatologiche dellAdulto August 2016 Phase 2
NCT02776605 Recruiting ALL PETHEMA Foundation June 2016 Phase 2
NCT01888562 Withdrawn Endometrial Neoplasms Washington University School of Medicine January 2016 --
NCT02627677 Recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals December 2015 Phase 3
NCT02448095 Recruiting Chronic Myeloid Leukemia|Philadelphia Positive Gruppo Italiano Malattie EMatologiche dellAdulto December 2015 --

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • 回答:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID