AZD7762
AZD7762是一种有效的，选择性Chk1抑制剂，无细胞试验中IC50为5 nM，作用于Chk2也同样有效，对CAM， Yes， Fyn， Lyn， Hck和Lck作用效果稍弱。Phase 1。
AZD7762 Chemical Structure
CAS: 860352-01-8
客户使用Selleck的AZD7762发表文献121篇
产品质控
批次：
纯度：
99.99%
99.99
AZD7762相关产品
| 相关靶点 | Chk1 Chk2 | 点击展开 |
|---|---|---|
| 相关化合物库 | 激酶抑制剂库 PI3K/Akt 抑制剂库 MAPK抑制剂库 DNA损伤/ DNA修复化合物库 细胞周期化合物库 | 点击展开 |
相关信号通路图
Chk抑制剂选择性比较
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| EW-16 | Growth Inhibition Assay | IC50=0.53774 μM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50=0.53657 μM | SANGER | ||
| SNU-423 | Growth Inhibition Assay | IC50=0.53466 μM | SANGER | ||
| SK-N-DZ | Growth Inhibition Assay | IC50=0.53078 μM | SANGER | ||
| CHL-1 | Growth Inhibition Assay | IC50=0.52551 μM | SANGER | ||
| HC-1 | Growth Inhibition Assay | IC50=0.52114 μM | SANGER | ||
| RKO | Growth Inhibition Assay | IC50=0.52019 μM | SANGER | ||
| CAL-51 | Growth Inhibition Assay | IC50=0.51437 μM | SANGER | ||
| SBC-5 | Growth Inhibition Assay | IC50=0.51344 μM | SANGER | ||
| SW626 | Growth Inhibition Assay | IC50=0.50633 μM | SANGER | ||
| A375 | Growth Inhibition Assay | IC50=0.49922 μM | SANGER | ||
| RT-112 | Growth Inhibition Assay | IC50=0.49921 μM | SANGER | ||
| HT-1080 | Growth Inhibition Assay | IC50=0.4927 μM | SANGER | ||
| HGC-27 | Growth Inhibition Assay | IC50=0.49115 μM | SANGER | ||
| HT-3 | Growth Inhibition Assay | IC50=0.4903 μM | SANGER | ||
| HSC-3 | Growth Inhibition Assay | IC50=0.48626 μM | SANGER | ||
| U031 | Growth Inhibition Assay | IC50=0.48234 μM | SANGER | ||
| NCI-H1563 | Growth Inhibition Assay | IC50=0.47035 μM | SANGER | ||
| HuP-T4 | Growth Inhibition Assay | IC50=0.46868 μM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50=0.46603 μM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50=0.46419 μM | SANGER | ||
| MOLT-13 | Growth Inhibition Assay | IC50=0.46294 μM | SANGER | ||
| D-392MG | Growth Inhibition Assay | IC50=0.45612 μM | SANGER | ||
| GI-ME-N | Growth Inhibition Assay | IC50=0.4546 μM | SANGER | ||
| TE-11 | Growth Inhibition Assay | IC50=0.45293 μM | SANGER | ||
| Hs-578-T | Growth Inhibition Assay | IC50=0.45278 μM | SANGER | ||
| A2058 | Growth Inhibition Assay | IC50=0.45136 μM | SANGER | ||
| Daoy | Growth Inhibition Assay | IC50=0.45103 μM | SANGER | ||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.44293 μM | SANGER | ||
| HCE-T | Growth Inhibition Assay | IC50=0.44187 μM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50=0.44185 μM | SANGER | ||
| CAL-12T | Growth Inhibition Assay | IC50=0.43288 μM | SANGER | ||
| A2780 | Growth Inhibition Assay | IC50=0.43162 μM | SANGER | ||
| EFO-27 | Growth Inhibition Assay | IC50=0.43049 μM | SANGER | ||
| LOXIMVI | Growth Inhibition Assay | IC50=0.42885 μM | SANGER | ||
| D-336MG | Growth Inhibition Assay | IC50=0.42138 μM | SANGER | ||
| SJSA-1 | Growth Inhibition Assay | IC50=0.41714 μM | SANGER | ||
| PC-14 | Growth Inhibition Assay | IC50=0.41661 μM | SANGER | ||
| GP5d | Growth Inhibition Assay | IC50=0.41225 μM | SANGER | ||
| FADU | Growth Inhibition Assay | IC50=0.41172 μM | SANGER | ||
| PFSK-1 | Growth Inhibition Assay | IC50=0.41092 μM | SANGER | ||
| COR-L23 | Growth Inhibition Assay | IC50=0.40286 μM | SANGER | ||
| NCI-H720 | Growth Inhibition Assay | IC50=0.40191 μM | SANGER | ||
| KYSE-180 | Growth Inhibition Assay | IC50=0.40151 μM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50=0.40131 μM | SANGER | ||
| OE33 | Growth Inhibition Assay | IC50=0.39118 μM | SANGER | ||
| MHH-NB-11 | Growth Inhibition Assay | IC50=0.3897 μM | SANGER | ||
| 786-0 | Growth Inhibition Assay | IC50=0.38823 μM | SANGER | ||
| Ca-Ski | Growth Inhibition Assay | IC50=0.38792 μM | SANGER | ||
| G-361 | Growth Inhibition Assay | IC50=0.38712 μM | SANGER | ||
| GAMG | Growth Inhibition Assay | IC50=0.38567 μM | SANGER | ||
| SW1990 | Growth Inhibition Assay | IC50=0.38353 μM | SANGER | ||
| TK10 | Growth Inhibition Assay | IC50=0.37948 μM | SANGER | ||
| LS-411N | Growth Inhibition Assay | IC50=0.37606 μM | SANGER | ||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.37497 μM | SANGER | ||
| T-24 | Growth Inhibition Assay | IC50=0.36985 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50=0.36482 μM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50=0.35696 μM | SANGER | ||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.35584 μM | SANGER | ||
| 8505C | Growth Inhibition Assay | IC50=0.35002 μM | SANGER | ||
| MKN1 | Growth Inhibition Assay | IC50=0.35002 μM | SANGER | ||
| KP-N-YN | Growth Inhibition Assay | IC50=0.34887 μM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50=0.34875 μM | SANGER | ||
| C32 | Growth Inhibition Assay | IC50=0.34682 μM | SANGER | ||
| MZ7-mel | Growth Inhibition Assay | IC50=0.34677 μM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50=0.34596 μM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50=0.34584 μM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50=0.3381 μM | SANGER | ||
| Detroit562 | Growth Inhibition Assay | IC50=0.33343 μM | SANGER | ||
| D-423MG | Growth Inhibition Assay | IC50=0.33142 μM | SANGER | ||
| KALS-1 | Growth Inhibition Assay | IC50=0.32594 μM | SANGER | ||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.32489 μM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50=0.32353 μM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.32021 μM | SANGER | ||
| NBsusSR | Growth Inhibition Assay | IC50=0.31819 μM | SANGER | ||
| HCC2998 | Growth Inhibition Assay | IC50=0.3165 μM | SANGER | ||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.31566 μM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50=0.31525 μM | SANGER | ||
| HCC70 | Growth Inhibition Assay | IC50=0.30665 μM | SANGER | ||
| Mewo | Growth Inhibition Assay | IC50=0.30431 μM | SANGER | ||
| FTC-133 | Growth Inhibition Assay | IC50=0.30265 μM | SANGER | ||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.29896 μM | SANGER | ||
| MSTO-211H | Growth Inhibition Assay | IC50=0.29855 μM | SANGER | ||
| COLO-829 | Growth Inhibition Assay | IC50=0.29845 μM | SANGER | ||
| SF295 | Growth Inhibition Assay | IC50=0.29802 μM | SANGER | ||
| HuO9 | Growth Inhibition Assay | IC50=0.29793 μM | SANGER | ||
| NCI-H28 | Growth Inhibition Assay | IC50=0.29704 μM | SANGER | ||
| COLO-684 | Growth Inhibition Assay | IC50=0.29406 μM | SANGER | ||
| HOP-92 | Growth Inhibition Assay | IC50=0.29279 μM | SANGER | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.29154 μM | SANGER | ||
| RXF393 | Growth Inhibition Assay | IC50=0.29008 μM | SANGER | ||
| EW-24 | Growth Inhibition Assay | IC50=0.2891 μM | SANGER | ||
| CAKI-1 | Growth Inhibition Assay | IC50=0.2868 μM | SANGER | ||
| H-EMC-SS | Growth Inhibition Assay | IC50=0.28354 μM | SANGER | ||
| SNU-C2B | Growth Inhibition Assay | IC50=0.28134 μM | SANGER | ||
| TYK-nu | Growth Inhibition Assay | IC50=0.2806 μM | SANGER | ||
| MKN45 | Growth Inhibition Assay | IC50=0.2798 μM | SANGER | ||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.27385 μM | SANGER | ||
| NCI-H1755 | Growth Inhibition Assay | IC50=0.27304 μM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50=0.27097 μM | SANGER | ||
| HCC1395 | Growth Inhibition Assay | IC50=0.27089 μM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.27059 μM | SANGER | ||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.26678 μM | SANGER | ||
| ABC-1 | Growth Inhibition Assay | IC50=0.26064 μM | SANGER | ||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.25768 μM | SANGER | ||
| MC116 | Growth Inhibition Assay | IC50=0.25654 μM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50=0.24761 μM | SANGER | ||
| KOSC-2 | Growth Inhibition Assay | IC50=0.24671 μM | SANGER | ||
| NCI-H510A | Growth Inhibition Assay | IC50=0.24626 μM | SANGER | ||
| T98G | Growth Inhibition Assay | IC50=0.24568 μM | SANGER | ||
| MPP-89 | Growth Inhibition Assay | IC50=0.24451 μM | SANGER | ||
| IGROV-1 | Growth Inhibition Assay | IC50=0.24401 μM | SANGER | ||
| SNU-387 | Growth Inhibition Assay | IC50=0.24339 μM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50=0.24243 μM | SANGER | ||
| MOLT-4 | Growth Inhibition Assay | IC50=0.2385 μM | SANGER | ||
| JAR | Growth Inhibition Assay | IC50=0.23238 μM | SANGER | ||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.23056 μM | SANGER | ||
| JVM-3 | Growth Inhibition Assay | IC50=0.23036 μM | SANGER | ||
| RH-1 | Growth Inhibition Assay | IC50=0.22666 μM | SANGER | ||
| KYSE-270 | Growth Inhibition Assay | IC50=0.22633 μM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.2257 μM | SANGER | ||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.22557 μM | SANGER | ||
| HEL | Growth Inhibition Assay | IC50=0.22454 μM | SANGER | ||
| 769-P | Growth Inhibition Assay | IC50=0.22298 μM | SANGER | ||
| COR-L105 | Growth Inhibition Assay | IC50=0.22235 μM | SANGER | ||
| EPLC-272H | Growth Inhibition Assay | IC50=0.22068 μM | SANGER | ||
| H4 | Growth Inhibition Assay | IC50=0.22062 μM | SANGER | ||
| KY821 | Growth Inhibition Assay | IC50=0.21429 μM | SANGER | ||
| HAL-01 | Growth Inhibition Assay | IC50=0.2097 μM | SANGER | ||
| TI-73 | Growth Inhibition Assay | IC50=0.20873 μM | SANGER | ||
| RS4-11 | Growth Inhibition Assay | IC50=0.20318 μM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50=0.20117 μM | SANGER | ||
| A427 | Growth Inhibition Assay | IC50=0.19832 μM | SANGER | ||
| CHP-212 | Growth Inhibition Assay | IC50=0.19782 μM | SANGER | ||
| NCI-H1395 | Growth Inhibition Assay | IC50=0.19761 μM | SANGER | ||
| GI-1 | Growth Inhibition Assay | IC50=0.19561 μM | SANGER | ||
| 5637 | Growth Inhibition Assay | IC50=0.19278 μM | SANGER | ||
| EW-1 | Growth Inhibition Assay | IC50=0.18905 μM | SANGER | ||
| SK-N-AS | Growth Inhibition Assay | IC50=0.18815 μM | SANGER | ||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.18599 μM | SANGER | ||
| GR-ST | Growth Inhibition Assay | IC50=0.17827 μM | SANGER | ||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.17464 μM | SANGER | ||
| ACN | Growth Inhibition Assay | IC50=0.17171 μM | SANGER | ||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.16847 μM | SANGER | ||
| KU812 | Growth Inhibition Assay | IC50=0.1683 μM | SANGER | ||
| TGBC24TKB | Growth Inhibition Assay | IC50=0.16535 μM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50=0.16503 μM | SANGER | ||
| ESS-1 | Growth Inhibition Assay | IC50=0.16413 μM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.16311 μM | SANGER | ||
| LoVo | Growth Inhibition Assay | IC50=0.16166 μM | SANGER | ||
| ES7 | Growth Inhibition Assay | IC50=0.16011 μM | SANGER | ||
| U-2-OS | Growth Inhibition Assay | IC50=0.15847 μM | SANGER | ||
| NB17 | Growth Inhibition Assay | IC50=0.15786 μM | SANGER | ||
| YH-13 | Growth Inhibition Assay | IC50=0.15674 μM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50=0.14967 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=0.14842 μM | SANGER | ||
| D-566MG | Growth Inhibition Assay | IC50=0.1469 μM | SANGER | ||
| M14 | Growth Inhibition Assay | IC50=0.14463 μM | SANGER | ||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.14288 μM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50=0.13925 μM | SANGER | ||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.13894 μM | SANGER | ||
| D-283MED | Growth Inhibition Assay | IC50=0.13687 μM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50=0.1368 μM | SANGER | ||
| ES5 | Growth Inhibition Assay | IC50=0.13476 μM | SANGER | ||
| ACHN | Growth Inhibition Assay | IC50=0.13369 μM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50=0.13325 μM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50=0.1316 μM | SANGER | ||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.13128 μM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50=0.13064 μM | SANGER | ||
| KYSE-140 | Growth Inhibition Assay | IC50=0.13041 μM | SANGER | ||
| MC-IXC | Growth Inhibition Assay | IC50=0.12843 μM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50=0.12484 μM | SANGER | ||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.1225 μM | SANGER | ||
| H9 | Growth Inhibition Assay | IC50=0.12165 μM | SANGER | ||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.1186 μM | SANGER | ||
| TGBC11TKB | Growth Inhibition Assay | IC50=0.11093 μM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50=0.11063 μM | SANGER | ||
| HSC-4 | Growth Inhibition Assay | IC50=0.10554 μM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50=0.102 μM | SANGER | ||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.10033 μM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50=0.09918 μM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50=0.09903 μM | SANGER | ||
| COLO-679 | Growth Inhibition Assay | IC50=0.09091 μM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50=0.08807 μM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50=0.08806 μM | SANGER | ||
| HuP-T3 | Growth Inhibition Assay | IC50=0.0871 μM | SANGER | ||
| MDA-MB-157 | Growth Inhibition Assay | IC50=0.08659 μM | SANGER | ||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.08421 μM | SANGER | ||
| OC-314 | Growth Inhibition Assay | IC50=0.07807 μM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50=0.07486 μM | SANGER | ||
| L-363 | Growth Inhibition Assay | IC50=0.0739 μM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50=0.07146 μM | SANGER | ||
| G-402 | Growth Inhibition Assay | IC50=0.0646 μM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.06255 μM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50=0.06196 μM | SANGER | ||
| NB14 | Growth Inhibition Assay | IC50=0.06136 μM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50=0.06115 μM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.06102 μM | SANGER | ||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.06025 μM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50=0.05158 μM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50=0.04592 μM | SANGER | ||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=0.04316 μM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50=0.04203 μM | SANGER | ||
| HCC1806 | Growth Inhibition Assay | IC50=0.04022 μM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50=0.03896 μM | SANGER | ||
| SW756 | Growth Inhibition Assay | IC50=0.03579 μM | SANGER | ||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=0.03442 μM | SANGER | ||
| ATN-1 | Growth Inhibition Assay | IC50=0.03417 μM | SANGER | ||
| ES4 | Growth Inhibition Assay | IC50=0.03251 μM | SANGER | ||
| KE-37 | Growth Inhibition Assay | IC50=0.03142 μM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50=0.0312 μM | SANGER | ||
| MLMA | Growth Inhibition Assay | IC50=0.02849 μM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.0142 μM | SANGER | ||
| A204 | Growth Inhibition Assay | IC50=0.00856 μM | SANGER | ||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.00643 μM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50=0.000425 μM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50=0.000415 μM | SANGER | ||
| KASUMI-1 | Growth Inhibition Assay | IC50=0.000234 μM | SANGER | ||
| A704 | Growth Inhibition Assay | IC50=0.53881 μM | SANGER | ||
| Ca9-22 | Growth Inhibition Assay | IC50=0.54077 μM | SANGER | ||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.5558 μM | SANGER | ||
| LB771-HNC | Growth Inhibition Assay | IC50=0.55933 μM | SANGER | ||
| EW-11 | Growth Inhibition Assay | IC50=0.56326 μM | SANGER | ||
| LC-2-ad | Growth Inhibition Assay | IC50=0.56522 μM | SANGER | ||
| KNS-62 | Growth Inhibition Assay | IC50=0.56553 μM | SANGER | ||
| CAL-62 | Growth Inhibition Assay | IC50=0.57121 μM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50=0.57421 μM | SANGER | ||
| OMC-1 | Growth Inhibition Assay | IC50=0.57497 μM | SANGER | ||
| AGS | Growth Inhibition Assay | IC50=0.58162 μM | SANGER | ||
| EW-22 | Growth Inhibition Assay | IC50=0.58375 μM | SANGER | ||
| KP-N-YS | Growth Inhibition Assay | IC50=0.58382 μM | SANGER | ||
| BFTC-909 | Growth Inhibition Assay | IC50=0.58833 μM | SANGER | ||
| PSN1 | Growth Inhibition Assay | IC50=0.59118 μM | SANGER | ||
| NB10 | Growth Inhibition Assay | IC50=0.59129 μM | SANGER | ||
| COLO-800 | Growth Inhibition Assay | IC50=0.60328 μM | SANGER | ||
| 647-V | Growth Inhibition Assay | IC50=0.61787 μM | SANGER | ||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.61861 μM | SANGER | ||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.6201 μM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50=0.62788 μM | SANGER | ||
| NCI-H661 | Growth Inhibition Assay | IC50=0.63712 μM | SANGER | ||
| ETK-1 | Growth Inhibition Assay | IC50=0.63721 μM | SANGER | ||
| SW1710 | Growth Inhibition Assay | IC50=0.64023 μM | SANGER | ||
| GCT | Growth Inhibition Assay | IC50=0.64935 μM | SANGER | ||
| SKG-IIIa | Growth Inhibition Assay | IC50=0.65036 μM | SANGER | ||
| LU-134-A | Growth Inhibition Assay | IC50=0.6565 μM | SANGER | ||
| Becker | Growth Inhibition Assay | IC50=0.65805 μM | SANGER | ||
| PANC-08-13 | Growth Inhibition Assay | IC50=0.66068 μM | SANGER | ||
| SW620 | Growth Inhibition Assay | IC50=0.66223 μM | SANGER | ||
| AsPC-1 | Growth Inhibition Assay | IC50=0.66361 μM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50=0.67625 μM | SANGER | ||
| RERF-LC-MS | Growth Inhibition Assay | IC50=0.67671 μM | SANGER | ||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.67852 μM | SANGER | ||
| 23132-87 | Growth Inhibition Assay | IC50=0.68306 μM | SANGER | ||
| BHY | Growth Inhibition Assay | IC50=0.68804 μM | SANGER | ||
| C2BBe1 | Growth Inhibition Assay | IC50=0.68928 μM | SANGER | ||
| A172 | Growth Inhibition Assay | IC50=0.69217 μM | SANGER | ||
| NCI-H727 | Growth Inhibition Assay | IC50=0.69812 μM | SANGER | ||
| NB69 | Growth Inhibition Assay | IC50=0.70549 μM | SANGER | ||
| HCC1937 | Growth Inhibition Assay | IC50=0.70631 μM | SANGER | ||
| HuCCT1 | Growth Inhibition Assay | IC50=0.70765 μM | SANGER | ||
| HH | Growth Inhibition Assay | IC50=0.70781 μM | SANGER | ||
| MN-60 | Growth Inhibition Assay | IC50=0.72124 μM | SANGER | ||
| CFPAC-1 | Growth Inhibition Assay | IC50=0.72257 μM | SANGER | ||
| HOP-62 | Growth Inhibition Assay | IC50=0.7262 μM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50=0.73552 μM | SANGER | ||
| SW1417 | Growth Inhibition Assay | IC50=0.73593 μM | SANGER | ||
| NCI-H1155 | Growth Inhibition Assay | IC50=0.73864 μM | SANGER | ||
| CAL-54 | Growth Inhibition Assay | IC50=0.7403 μM | SANGER | ||
| Saos-2 | Growth Inhibition Assay | IC50=0.74584 μM | SANGER | ||
| NCI-H446 | Growth Inhibition Assay | IC50=0.74806 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50=0.74908 μM | SANGER | ||
| PA-1 | Growth Inhibition Assay | IC50=0.74968 μM | SANGER | ||
| HCC38 | Growth Inhibition Assay | IC50=0.74984 μM | SANGER | ||
| DMS-273 | Growth Inhibition Assay | IC50=0.75456 μM | SANGER | ||
| U-266 | Growth Inhibition Assay | IC50=0.76262 μM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50=0.77355 μM | SANGER | ||
| UACC-62 | Growth Inhibition Assay | IC50=0.77553 μM | SANGER | ||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.78211 μM | SANGER | ||
| SW982 | Growth Inhibition Assay | IC50=0.78432 μM | SANGER | ||
| 8305C | Growth Inhibition Assay | IC50=0.78939 μM | SANGER | ||
| SW48 | Growth Inhibition Assay | IC50=0.7924 μM | SANGER | ||
| NB5 | Growth Inhibition Assay | IC50=0.79651 μM | SANGER | ||
| J82 | Growth Inhibition Assay | IC50=0.80487 μM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50=0.81349 μM | SANGER | ||
| HEC-1 | Growth Inhibition Assay | IC50=0.81371 μM | SANGER | ||
| AU565 | Growth Inhibition Assay | IC50=0.8244 μM | SANGER | ||
| KYSE-520 | Growth Inhibition Assay | IC50=0.82636 μM | SANGER | ||
| HTC-C3 | Growth Inhibition Assay | IC50=0.83474 μM | SANGER | ||
| AN3-CA | Growth Inhibition Assay | IC50=0.83711 μM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50=0.84484 μM | SANGER | ||
| NCI-N87 | Growth Inhibition Assay | IC50=0.84556 μM | SANGER | ||
| HN | Growth Inhibition Assay | IC50=0.84591 μM | SANGER | ||
| SiHa | Growth Inhibition Assay | IC50=0.85882 μM | SANGER | ||
| C-33-A | Growth Inhibition Assay | IC50=0.86185 μM | SANGER | ||
| A673 | Growth Inhibition Assay | IC50=0.86536 μM | SANGER | ||
| HSC-2 | Growth Inhibition Assay | IC50=0.87334 μM | SANGER | ||
| LN-405 | Growth Inhibition Assay | IC50=0.87731 μM | SANGER | ||
| HOS | Growth Inhibition Assay | IC50=0.87995 μM | SANGER | ||
| SF268 | Growth Inhibition Assay | IC50=0.88097 μM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50=0.88602 μM | SANGER | ||
| HT-29 | Growth Inhibition Assay | IC50=0.89417 μM | SANGER | ||
| NCI-H292 | Growth Inhibition Assay | IC50=0.89777 μM | SANGER | ||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.90316 μM | SANGER | ||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.90578 μM | SANGER | ||
| D-263MG | Growth Inhibition Assay | IC50=0.90943 μM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50=0.90984 μM | SANGER | ||
| SW1088 | Growth Inhibition Assay | IC50=0.91552 μM | SANGER | ||
| NCI-H1048 | Growth Inhibition Assay | IC50=0.91852 μM | SANGER | ||
| A431 | Growth Inhibition Assay | IC50=0.92452 μM | SANGER | ||
| SW1783 | Growth Inhibition Assay | IC50=0.93251 μM | SANGER | ||
| NCI-H2452 | Growth Inhibition Assay | IC50=0.93557 μM | SANGER | ||
| OAW-42 | Growth Inhibition Assay | IC50=0.93665 μM | SANGER | ||
| HuO-3N1 | Growth Inhibition Assay | IC50=0.94092 μM | SANGER | ||
| K5 | Growth Inhibition Assay | IC50=0.94127 μM | SANGER | ||
| SW1573 | Growth Inhibition Assay | IC50=0.94227 μM | SANGER | ||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.94237 μM | SANGER | ||
| HCC1187 | Growth Inhibition Assay | IC50=0.96749 μM | SANGER | ||
| HCE-4 | Growth Inhibition Assay | IC50=0.9696 μM | SANGER | ||
| HPAF-II | Growth Inhibition Assay | IC50=0.97028 μM | SANGER | ||
| MEL-HO | Growth Inhibition Assay | IC50=0.97945 μM | SANGER | ||
| LCLC-103H | Growth Inhibition Assay | IC50=0.98027 μM | SANGER | ||
| CAL-33 | Growth Inhibition Assay | IC50=0.98378 μM | SANGER | ||
| NB6 | Growth Inhibition Assay | IC50=0.98462 μM | SANGER | ||
| BFTC-905 | Growth Inhibition Assay | IC50=0.98473 μM | SANGER | ||
| NMC-G1 | Growth Inhibition Assay | IC50=0.98592 μM | SANGER | ||
| RCM-1 | Growth Inhibition Assay | IC50=0.99258 μM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50=1.00412 μM | SANGER | ||
| NCI-H2030 | Growth Inhibition Assay | IC50=1.01813 μM | SANGER | ||
| SCC-4 | Growth Inhibition Assay | IC50=1.01859 μM | SANGER | ||
| KYSE-410 | Growth Inhibition Assay | IC50=1.0352 μM | SANGER | ||
| NCI-H1650 | Growth Inhibition Assay | IC50=1.03971 μM | SANGER | ||
| S-117 | Growth Inhibition Assay | IC50=1.04 μM | SANGER | ||
| GAK | Growth Inhibition Assay | IC50=1.05075 μM | SANGER | ||
| KYSE-450 | Growth Inhibition Assay | IC50=1.05336 μM | SANGER | ||
| M059J | Growth Inhibition Assay | IC50=1.06828 μM | SANGER | ||
| LAN-6 | Growth Inhibition Assay | IC50=1.07773 μM | SANGER | ||
| NCI-H1651 | Growth Inhibition Assay | IC50=1.09352 μM | SANGER | ||
| KMOE-2 | Growth Inhibition Assay | IC50=1.10973 μM | SANGER | ||
| SN12C | Growth Inhibition Assay | IC50=1.11785 μM | SANGER | ||
| SW900 | Growth Inhibition Assay | IC50=1.12251 μM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50=1.12291 μM | SANGER | ||
| HO-1-N-1 | Growth Inhibition Assay | IC50=1.14353 μM | SANGER | ||
| BHT-101 | Growth Inhibition Assay | IC50=1.14714 μM | SANGER | ||
| 639-V | Growth Inhibition Assay | IC50=1.1667 μM | SANGER | ||
| RVH-421 | Growth Inhibition Assay | IC50=1.19347 μM | SANGER | ||
| SW780 | Growth Inhibition Assay | IC50=1.19515 μM | SANGER | ||
| SNB75 | Growth Inhibition Assay | IC50=1.19819 μM | SANGER | ||
| U-87-MG | Growth Inhibition Assay | IC50=1.21334 μM | SANGER | ||
| TE-1 | Growth Inhibition Assay | IC50=1.21367 μM | SANGER | ||
| CAS-1 | Growth Inhibition Assay | IC50=1.21418 μM | SANGER | ||
| MKN7 | Growth Inhibition Assay | IC50=1.21478 μM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50=1.21773 μM | SANGER | ||
| NCI-H1693 | Growth Inhibition Assay | IC50=1.22758 μM | SANGER | ||
| KGN | Growth Inhibition Assay | IC50=1.23359 μM | SANGER | ||
| NCI-H2347 | Growth Inhibition Assay | IC50=1.23525 μM | SANGER | ||
| MFM-223 | Growth Inhibition Assay | IC50=1.24343 μM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50=1.26666 μM | SANGER | ||
| SAS | Growth Inhibition Assay | IC50=1.26672 μM | SANGER | ||
| BT-549 | Growth Inhibition Assay | IC50=1.26782 μM | SANGER | ||
| NCI-H2228 | Growth Inhibition Assay | IC50=1.2864 μM | SANGER | ||
| BxPC-3 | Growth Inhibition Assay | IC50=1.30672 μM | SANGER | ||
| SCH | Growth Inhibition Assay | IC50=1.32503 μM | SANGER | ||
| GMS-10 | Growth Inhibition Assay | IC50=1.34551 μM | SANGER | ||
| GB-1 | Growth Inhibition Assay | IC50=1.37564 μM | SANGER | ||
| NCI-H520 | Growth Inhibition Assay | IC50=1.38168 μM | SANGER | ||
| GCIY | Growth Inhibition Assay | IC50=1.39051 μM | SANGER | ||
| HuH-7 | Growth Inhibition Assay | IC50=1.39501 μM | SANGER | ||
| IA-LM | Growth Inhibition Assay | IC50=1.39986 μM | SANGER | ||
| BB49-HNC | Growth Inhibition Assay | IC50=1.40231 μM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50=1.41187 μM | SANGER | ||
| NCI-H650 | Growth Inhibition Assay | IC50=1.41795 μM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50=1.41954 μM | SANGER | ||
| KINGS-1 | Growth Inhibition Assay | IC50=1.42018 μM | SANGER | ||
| HCT-116 | Growth Inhibition Assay | IC50=1.42176 μM | SANGER | ||
| NCI-H1573 | Growth Inhibition Assay | IC50=1.42257 μM | SANGER | ||
| NCI-H358 | Growth Inhibition Assay | IC50=1.43128 μM | SANGER | ||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=1.44319 μM | SANGER | ||
| KP-4 | Growth Inhibition Assay | IC50=1.46151 μM | SANGER | ||
| LK-2 | Growth Inhibition Assay | IC50=1.46382 μM | SANGER | ||
| EFM-19 | Growth Inhibition Assay | IC50=1.48104 μM | SANGER | ||
| GT3TKB | Growth Inhibition Assay | IC50=1.48613 μM | SANGER | ||
| A549 | Growth Inhibition Assay | IC50=1.48833 μM | SANGER | ||
| no-11 | Growth Inhibition Assay | IC50=1.49026 μM | SANGER | ||
| SK-N-FI | Growth Inhibition Assay | IC50=1.4938 μM | SANGER | ||
| NCI-H2170 | Growth Inhibition Assay | IC50=1.52313 μM | SANGER | ||
| NCI-H460 | Growth Inhibition Assay | IC50=1.52961 μM | SANGER | ||
| NCI-H526 | Growth Inhibition Assay | IC50=1.53706 μM | SANGER | ||
| KYSE-510 | Growth Inhibition Assay | IC50=1.5825 μM | SANGER | ||
| YKG-1 | Growth Inhibition Assay | IC50=1.58328 μM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50=1.60227 μM | SANGER | ||
| MDA-MB-231 | Growth Inhibition Assay | IC50=1.6038 μM | SANGER | ||
| HT55 | Growth Inhibition Assay | IC50=1.60591 μM | SANGER | ||
| NCI-H1793 | Growth Inhibition Assay | IC50=1.61345 μM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50=1.63456 μM | SANGER | ||
| DSH1 | Growth Inhibition Assay | IC50=1.69256 μM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50=1.69983 μM | SANGER | ||
| DB | Growth Inhibition Assay | IC50=1.70067 μM | SANGER | ||
| ME-180 | Growth Inhibition Assay | IC50=1.71785 μM | SANGER | ||
| BT-20 | Growth Inhibition Assay | IC50=1.72407 μM | SANGER | ||
| A498 | Growth Inhibition Assay | IC50=1.72963 μM | SANGER | ||
| UMC-11 | Growth Inhibition Assay | IC50=1.76749 μM | SANGER | ||
| EC-GI-10 | Growth Inhibition Assay | IC50=1.77556 μM | SANGER | ||
| NCI-H630 | Growth Inhibition Assay | IC50=1.78642 μM | SANGER | ||
| EGI-1 | Growth Inhibition Assay | IC50=1.80267 μM | SANGER | ||
| 22RV1 | Growth Inhibition Assay | IC50=1.80853 μM | SANGER | ||
| LS-123 | Growth Inhibition Assay | IC50=1.81214 μM | SANGER | ||
| OAW-28 | Growth Inhibition Assay | IC50=1.84746 μM | SANGER | ||
| CaR-1 | Growth Inhibition Assay | IC50=1.8707 μM | SANGER | ||
| HT | Growth Inhibition Assay | IC50=1.87342 μM | SANGER | ||
| BCPAP | Growth Inhibition Assay | IC50=1.88676 μM | SANGER | ||
| RMG-I | Growth Inhibition Assay | IC50=1.90787 μM | SANGER | ||
| C8166 | Growth Inhibition Assay | IC50=1.90932 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50=1.92035 μM | SANGER | ||
| SCC-9 | Growth Inhibition Assay | IC50=1.99105 μM | SANGER | ||
| EKVX | Growth Inhibition Assay | IC50=2.00154 μM | SANGER | ||
| KU-19-19 | Growth Inhibition Assay | IC50=2.00372 μM | SANGER | ||
| K-562 | Growth Inhibition Assay | IC50=2.00898 μM | SANGER | ||
| SW962 | Growth Inhibition Assay | IC50=2.04059 μM | SANGER | ||
| MDA-MB-453 | Growth Inhibition Assay | IC50=2.05442 μM | SANGER | ||
| BPH-1 | Growth Inhibition Assay | IC50=2.07098 μM | SANGER | ||
| DK-MG | Growth Inhibition Assay | IC50=2.08603 μM | SANGER | ||
| Capan-2 | Growth Inhibition Assay | IC50=2.10041 μM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50=2.12541 μM | SANGER | ||
| DOK | Growth Inhibition Assay | IC50=2.13147 μM | SANGER | ||
| YAPC | Growth Inhibition Assay | IC50=2.15307 μM | SANGER | ||
| AM-38 | Growth Inhibition Assay | IC50=2.17015 μM | SANGER | ||
| EFO-21 | Growth Inhibition Assay | IC50=2.17788 μM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50=2.19271 μM | SANGER | ||
| RH-18 | Growth Inhibition Assay | IC50=2.19369 μM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50=2.19596 μM | SANGER | ||
| COLO-668 | Growth Inhibition Assay | IC50=2.29973 μM | SANGER | ||
| RPMI-2650 | Growth Inhibition Assay | IC50=2.32659 μM | SANGER | ||
| HMV-II | Growth Inhibition Assay | IC50=2.33868 μM | SANGER | ||
| NCI-H2342 | Growth Inhibition Assay | IC50=2.34603 μM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50=2.38204 μM | SANGER | ||
| L-428 | Growth Inhibition Assay | IC50=2.38794 μM | SANGER | ||
| U-118-MG | Growth Inhibition Assay | IC50=2.39805 μM | SANGER | ||
| RO82-W-1 | Growth Inhibition Assay | IC50=2.43727 μM | SANGER | ||
| NCI-H2291 | Growth Inhibition Assay | IC50=2.46994 μM | SANGER | ||
| SK-OV-3 | Growth Inhibition Assay | IC50=2.50249 μM | SANGER | ||
| NCI-H441 | Growth Inhibition Assay | IC50=2.50305 μM | SANGER | ||
| NCI-H2009 | Growth Inhibition Assay | IC50=2.52934 μM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50=2.53747 μM | SANGER | ||
| PANC-10-05 | Growth Inhibition Assay | IC50=2.61116 μM | SANGER | ||
| CAL-85-1 | Growth Inhibition Assay | IC50=2.66161 μM | SANGER | ||
| PC-3 | Growth Inhibition Assay | IC50=2.66611 μM | SANGER | ||
| COLO-824 | Growth Inhibition Assay | IC50=2.67374 μM | SANGER | ||
| D-502MG | Growth Inhibition Assay | IC50=2.70406 μM | SANGER | ||
| SBC-1 | Growth Inhibition Assay | IC50=2.71627 μM | SANGER | ||
| CAPAN-1 | Growth Inhibition Assay | IC50=2.71949 μM | SANGER | ||
| D-247MG | Growth Inhibition Assay | IC50=2.73756 μM | SANGER | ||
| CAL-39 | Growth Inhibition Assay | IC50=2.86389 μM | SANGER | ||
| NCI-H2087 | Growth Inhibition Assay | IC50=2.88431 μM | SANGER | ||
| NB7 | Growth Inhibition Assay | IC50=2.92139 μM | SANGER | ||
| NCI-H1437 | Growth Inhibition Assay | IC50=2.92257 μM | SANGER | ||
| RD | Growth Inhibition Assay | IC50=2.99939 μM | SANGER | ||
| TCCSUP | Growth Inhibition Assay | IC50=3.02636 μM | SANGER | ||
| MKN28 | Growth Inhibition Assay | IC50=3.03463 μM | SANGER | ||
| NCI-H596 | Growth Inhibition Assay | IC50=3.0671 μM | SANGER | ||
| SW948 | Growth Inhibition Assay | IC50=3.09693 μM | SANGER | ||
| WM-115 | Growth Inhibition Assay | IC50=3.11827 μM | SANGER | ||
| HCC1954 | Growth Inhibition Assay | IC50=3.12141 μM | SANGER | ||
| MS-1 | Growth Inhibition Assay | IC50=3.18474 μM | SANGER | ||
| SW13 | Growth Inhibition Assay | IC50=3.2326 μM | SANGER | ||
| OE19 | Growth Inhibition Assay | IC50=3.28489 μM | SANGER | ||
| HT-1197 | Growth Inhibition Assay | IC50=3.29179 μM | SANGER | ||
| HLE | Growth Inhibition Assay | IC50=3.3281 μM | SANGER | ||
| NUGC-3 | Growth Inhibition Assay | IC50=3.44761 μM | SANGER | ||
| UACC-257 | Growth Inhibition Assay | IC50=3.52417 μM | SANGER | ||
| SK-MEL-3 | Growth Inhibition Assay | IC50=3.53214 μM | SANGER | ||
| KNS-81-FD | Growth Inhibition Assay | IC50=3.562 μM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50=3.57986 μM | SANGER | ||
| KLE | Growth Inhibition Assay | IC50=3.59867 μM | SANGER | ||
| NCI-H2052 | Growth Inhibition Assay | IC50=3.60009 μM | SANGER | ||
| NCI-H1838 | Growth Inhibition Assay | IC50=3.81119 μM | SANGER | ||
| NCI-H1623 | Growth Inhibition Assay | IC50=4.01396 μM | SANGER | ||
| SCC-25 | Growth Inhibition Assay | IC50=4.23597 μM | SANGER | ||
| CP66-MEL | Growth Inhibition Assay | IC50=4.25191 μM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50=4.29271 μM | SANGER | ||
| LU-99A | Growth Inhibition Assay | IC50=4.31345 μM | SANGER | ||
| CAMA-1 | Growth Inhibition Assay | IC50=4.352 μM | SANGER | ||
| SK-MEL-30 | Growth Inhibition Assay | IC50=4.41913 μM | SANGER | ||
| KURAMOCHI | Growth Inhibition Assay | IC50=4.45528 μM | SANGER | ||
| BEN | Growth Inhibition Assay | IC50=4.52362 μM | SANGER | ||
| NCI-H226 | Growth Inhibition Assay | IC50=4.54871 μM | SANGER | ||
| CAL-27 | Growth Inhibition Assay | IC50=4.71694 μM | SANGER | ||
| G-401 | Growth Inhibition Assay | IC50=4.83841 μM | SANGER | ||
| CAL-120 | Growth Inhibition Assay | IC50=4.84991 μM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50=5.14506 μM | SANGER | ||
| KYSE-70 | Growth Inhibition Assay | IC50=5.14859 μM | SANGER | ||
| NCI-H1648 | Growth Inhibition Assay | IC50=5.29782 μM | SANGER | ||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=5.44014 μM | SANGER | ||
| NCI-H2029 | Growth Inhibition Assay | IC50=5.48022 μM | SANGER | ||
| LS-1034 | Growth Inhibition Assay | IC50=5.66889 μM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50=5.70345 μM | SANGER | ||
| MDA-MB-415 | Growth Inhibition Assay | IC50=5.7081 μM | SANGER | ||
| TE-6 | Growth Inhibition Assay | IC50=5.74182 μM | SANGER | ||
| SK-MEL-24 | Growth Inhibition Assay | IC50=5.74564 μM | SANGER | ||
| HUTU-80 | Growth Inhibition Assay | IC50=5.75333 μM | SANGER | ||
| OCUB-M | Growth Inhibition Assay | IC50=5.77563 μM | SANGER | ||
| IGR-1 | Growth Inhibition Assay | IC50=5.86894 μM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50=6.24585 μM | SANGER | ||
| COLO-680N | Growth Inhibition Assay | IC50=6.39403 μM | SANGER | ||
| NB12 | Growth Inhibition Assay | IC50=6.79722 μM | SANGER | ||
| SNU-449 | Growth Inhibition Assay | IC50=6.99591 μM | SANGER | ||
| D-542MG | Growth Inhibition Assay | IC50=7.12299 μM | SANGER | ||
| COLO-792 | Growth Inhibition Assay | IC50=7.87127 μM | SANGER | ||
| NCI-H810 | Growth Inhibition Assay | IC50=8.02984 μM | SANGER | ||
| T47D | Growth Inhibition Assay | IC50=8.16024 μM | SANGER | ||
| Calu-3 | Growth Inhibition Assay | IC50=8.28886 μM | SANGER | ||
| COLO-741 | Growth Inhibition Assay | IC50=8.93093 μM | SANGER | ||
| LU-135 | Growth Inhibition Assay | IC50=9.03452 μM | SANGER | ||
| COLO-678 | Growth Inhibition Assay | IC50=9.28844 μM | SANGER | ||
| NCI-H2126 | Growth Inhibition Assay | IC50=9.33919 μM | SANGER | ||
| SK-MEL-28 | Growth Inhibition Assay | IC50=9.53596 μM | SANGER | ||
| MFE-280 | Growth Inhibition Assay | IC50=10.0229 μM | SANGER | ||
| DBTRG-05MG | Growth Inhibition Assay | IC50=10.4369 μM | SANGER | ||
| RCC10RGB | Growth Inhibition Assay | IC50=10.5255 μM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=10.6852 μM | SANGER | ||
| C3A | Growth Inhibition Assay | IC50=12.3172 μM | SANGER | ||
| MHH-ES-1 | Growth Inhibition Assay | IC50=12.5284 μM | SANGER | ||
| LU-139 | Growth Inhibition Assay | IC50=12.6333 μM | SANGER | ||
| KNS-42 | Growth Inhibition Assay | IC50=12.8771 μM | SANGER | ||
| MCF7 | Growth Inhibition Assay | IC50=13.2365 μM | SANGER | ||
| SW872 | Growth Inhibition Assay | IC50=14.5461 μM | SANGER | ||
| HT-1376 | Growth Inhibition Assay | IC50=14.8582 μM | SANGER | ||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=15.1741 μM | SANGER | ||
| NCI-H2405 | Growth Inhibition Assay | IC50=15.4474 μM | SANGER | ||
| KYSE-150 | Growth Inhibition Assay | IC50=15.7611 μM | SANGER | ||
| SW837 | Growth Inhibition Assay | IC50=16.0124 μM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50=19.726 μM | SANGER | ||
| JEG-3 | Growth Inhibition Assay | IC50=20.3577 μM | SANGER | ||
| SK-MEL-1 | Growth Inhibition Assay | IC50=20.7836 μM | SANGER | ||
| SK-HEP-1 | Growth Inhibition Assay | IC50=21.5541 μM | SANGER | ||
| NCI-H1770 | Growth Inhibition Assay | IC50=23.4086 μM | SANGER | ||
| MG-63 | Growth Inhibition Assay | IC50=23.7673 μM | SANGER | ||
| ECC10 | Growth Inhibition Assay | IC50=25.571 μM | SANGER | ||
| SW1463 | Growth Inhibition Assay | IC50=27.8316 μM | SANGER | ||
| JVM-2 | Growth Inhibition Assay | IC50=28.3248 μM | SANGER | ||
| HCT-15 | Growth Inhibition Assay | IC50=28.4192 μM | SANGER | ||
| CAL-72 | Growth Inhibition Assay | IC50=31.4912 μM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50=32.8858 μM | SANGER | ||
| BT-474 | Growth Inhibition Assay | IC50=33.0843 μM | SANGER | ||
| NCI-H1092 | Growth Inhibition Assay | IC50=33.5145 μM | SANGER | ||
| Mo-T | Growth Inhibition Assay | IC50=37.3585 μM | SANGER | ||
| DU-145 | Growth Inhibition Assay | IC50=40.6295 μM | SANGER | ||
| NCI-H1666 | Growth Inhibition Assay | IC50=42.4488 μM | SANGER | ||
| IST-MES1 | Growth Inhibition Assay | IC50=46.4196 μM | SANGER | ||
| SW1116 | Growth Inhibition Assay | IC50=48.1756 μM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50=48.5026 μM | SANGER | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | AZD7762是一种有效的，选择性Chk1抑制剂，无细胞试验中IC50为5 nM，作用于Chk2也同样有效，对CAM， Yes， Fyn， Lyn， Hck和Lck作用效果稍弱。Phase 1。 | ||||
|---|---|---|---|---|---|
| 靶点 |
|
| 体外研究(In Vitro) | ||||
| 体外研究活性 | AZD7762是Chk1选择性抑制剂, 通过与Chk1的ATP结合位点可逆结合而抑制cdc25C肽段的Chk1磷酸化，IC50 为5 nM，Ki为 3.6 nM。AZD7762诱导细胞周期停滞，EC50为0.620 μM, 且通过阻断cdc25A依赖chk1的降解 和Cyclin A的激活，显著废除Camptothecin诱导的G2期停滞，EC50为10 nM。300 nM AZD7762增强Gemcitabine作用于SW620的抗癌活性，也增强 Topotecan作用于MDA-MB-231 的抗癌活性，通过降低 GI50 值，分别从24.1 nM和2.25 μM 降到1.08 nM 和0.15 μM。[1] AZD7762 作用于多种携带p53野生型，p53突变型，MDM2增添，或p14 缺失的神经母细胞瘤细胞系，IC50为82.6 nM 到505.9 nM。[2] | |||
|---|---|---|---|---|
| 激酶实验 | Chk1激酶实验 | |||
| 使用杆状病毒载体，融合在昆虫细胞中，重组人类Chk1表达作为谷胱甘肽S转移酶，通过胱甘肽亲和层析纯化。合成的肽底物 (N-biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR)用于Chk1 合成。实验中，肽和ATP(完全和40 nCi [33P]ATP) 的终浓度分别为0.8和1 μM。不同浓度AZD7762, 含肽和chk1激酶和ATP的buffer相继加到384孔板中。然后温育2小时,加入含EDTA和邻近闪烁分析(SPA)圆球微粒的buffer终止反应, 然后使用TopCount计数器读数。进行数据分析，测定IC50值。 | ||||
| 细胞实验 | 细胞系 | HT29,SW620和MDA-MB-231细胞 | ||
| 浓度 | 溶于DMSO, 终浓度为12.5 μM 左右 | |||
| 孵育时间 | 20或48小时 | |||
| 方法 | 检测点废除实验中, 用Camptothecin(拓扑异构酶I 抑制剂;0.07 μg/mL)处理HT29细胞2小时，诱导产生G2期检测点。然后用AZD7762(12.5 μM 到6 nM)12点滴定法和Nocodazole处理细胞20分钟。细胞和3.7%甲醛混合1小时，用含0.05% Triton X的PBS渗透处理, 然后与anti-phH3抗体温育1小时，然后用Hoechst染料染色1小时。使用ArrayScan测定有丝分裂指数，作为进行有丝分裂细胞的百分数。增强实验中,用Gemcitabine 9点滴定（0.01到 100 nM）和固定剂量AZD7762(300 nM)处理SW620或MDA-MB-231细胞24小时。24小时后, 移除培养基，单独加入AZD7762，再处理24小时。细胞在无AZD7762培养基中再温育72小时，通过MTT测定细胞增殖。 | |||
| 实验图片 | 检测方法 | 检测指标 | 实验图片 | PMID |
| Western blot | pChk1 / Chk1 / Wee1 / p21 / p53 |
|
29963769 | |
| Growth inhibition assay | Cell viability |
|
23715154 | |
| 体内研究(In Vivo) | ||
| 体内研究活性 | AZD7762 按25 mg/kg剂量单独作用于携带H460-DNp53移植瘤的小鼠和携带SW620移植瘤的小鼠，显示很弱的抗癌活性,但是和Gemcitabine(60 mg/kg)联用处理这两种携带移植瘤的小鼠，则具有强抗癌活性。AZD7762和Gemcitabine(10 mg/kg) 联用作用于携带H460-DNp53移植瘤大鼠，抑制肿瘤体积，这种作用存在剂量依赖性。AZD7762 (25 mg/kg)和Irinotecan (25或50 mg/kg) 联用作用于携带SW620移植瘤的小鼠，引起全部肿瘤衰退。[1] | |
|---|---|---|
| 动物实验 | Animal Models | 皮下注射H460-DNp53细胞或SW620细胞的雄性NCr小鼠, 或皮下注射H460-DNp53细胞的雄性rnu大鼠 |
| Dosages | ~25 mg/kg | |
| Administration | 静脉注射 | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT00937664 | Terminated | Cancer|Solid Tumors|Advanced Solid Malignancies |
AstraZeneca |
July 2009 | Phase 1 |
| NCT00473616 | Terminated | Advanced Solid Tumors|Cancer|Advanced Solid Malignancies |
AstraZeneca |
May 2007 | Phase 1 |
| NCT00413686 | Completed | Solid Tumors |
AstraZeneca |
December 2006 | Phase 1 |
化学信息&溶解度
| 分子量 | 362.42 | 分子式 | C17H19FN4O2S |
| CAS号 | 860352-01-8 | SDF | Download AZD7762 SDF |
| Smiles | C1CC(CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N | ||
| 储存条件(自收到货起) | |||
|
体外溶解度 |
DMSO : 73 mg/mL ( (201.42 mM)； DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Ethanol : 3 mg/mL Water : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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* 必填项
常见问题及建议解决方法
问题 1:
If I want to use the inhibitor for i.p. injection, can I use DMSO to dissolve it?
回答：
Since DMSO has low toxicity with i.p. injection, hydroxyproplyl-β-cyclodextrin is consider a safer co-solvent in compound formulation. In a previous literature report, 11.3% hydroxyproplyl-β-cyclodextrin was used to formulate this compound for i.v. injection.
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