Dactolisib (BEZ235, NVP-BEZ235)

目录号：S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3K 和 mTOR 抑制剂，在无细胞试验中，抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR，IC50 为 21 nM，而对 Akt 和 PDK1 的抑制作用很弱。Phase 2。

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客户购买Selleck的此次产品后发表的文献82篇：

客户使用该产品的11个实验数据：

  • Level of phospho-proteins in RTK and PI3K–Akt–mTOR pathways in treated tumours, detected with western blot.

    Nature, 2017, 728-732. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • (B) The effects of AZD2014, BEZ235, lapatinib, LEE011, pazopanib on PI3K/AKT signaling in sarcoma PDC line were determined by immunoblotting analysis. Cells were treated with 1 μM of the indicated drugs for 72 h.

    Transl Oncol, 2016, 9(3):197-202. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    The effects of LY294002, rapamycin and NVP-BEZ235 on activation of PI3K-Akt-mTOR pathway in hepatocytes. (a) The mRNA expression (PI3K, Akt, mTOR, raptor) by Real-Time PCR, (b) protein expression (PI3K, Akt, mTOR, S6K) by ELISA kits; (c) protein expression of S6K and P-S6K by western blotting. The different letters indicated significant differences (P <0.05). LY = LY294002; rapa = rapamycin; NVP = NVP-BEZ235.

    Animal, 2016, 10(8):1319-27. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3K 和 mTOR 抑制剂，在无细胞试验中，抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR，IC50 为 21 nM，而对 Akt 和 PDK1 的抑制作用很弱。Phase 2。
靶点
p110α [1]
(Cell-free assay)		 p110γ [1]
(Cell-free assay)		 mTOR (p70S6K) [1]
(Cell-free assay)		 p110δ [1]
(Cell-free assay)		 ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
体外研究

BEZ235显著降低mTOR活化的激酶p70S6K的磷酸化水平。BEZ235导致S235/S236P-RPS6水平减少，IC50为6.5 nM。BEZ235抗mTOR的活性使用生化mTOR K-LISA试验测定，IC50为20.7 nM。BEZ235对其β旁系同源物的活性稍弱，IC50为75 nM。在人肿瘤细胞中，PI3K/Akt/mTOR通路经常被组成性活化。BEZ235阻断PI3K和mTOR激酶活性，通过结合于这些酶的ATP结合槽发挥作用。用逐渐增加浓度BEZ235处理PTEN-null细胞系PC3M和U87MG时，导致细胞增殖剂量依赖性减少，平均GI50为10-12 nM。[1] BEZ235是一种mTORC1/2催化抑制剂。[2]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei NFnQSZdCdnSrbXnjdo9jcWGuIFHzd4F6 NWC2[JV2OThiaB?= NWS1OWZkTE2VTx?= M4HSOmFvfGm2conwZY5we2:vYXygZYN1cX[rdImge4l1cCCHQ{WwJI9nKDBwMECyOUDPxE1? MnXONlQ5ODV7NE[=
MCF7 MoLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XES|AvODFvMUCwJO69VQ>? NITBUGI1QCCq MnzZSG1UVw>? MmTnTWM2OD1yLkezJO69VQ>? NV:x[FM1OjN6N{G5NFQ>
HCT116 NFnS[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nJV|AvODFvMUCwJO69VQ>? M{La[lQ5KGh? MWXEUXNQ M{T1fmlEPTB;MT6xOkDPxE1? NX3HeHc5OjN6N{G5NFQ>
U87MG NFPRcINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonPNE4xOS1zMECg{txO M2nodlQ5KGh? MUfEUXNQ NGLwWWVKSzVyPUGuN|Ih|ryP M1nR[lI{QDdzOUC0
HBC4 MkXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfuSIExNjBzLUGwNEDPxE1? Ml7aOFghcA>? M4rzb2xw\yCJSUWwQU05NjZzIF2= M1\pTVIzOzN4MkS2
BSY1 M{fmfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\mUmVxOC5yMT2xNFAh|ryP Mo\1OFghcA>? Mlm5UI9oKEeLNUC9MVgvPDhiTR?= MV[yNlM{PjJ2Nh?=
HBC5 M4rQcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO0blAxNjBzLUGwNEDPxE1? MojiOFghcA>? NYfOXot1VG:pIFfJOVA:NTdwOEegUS=> NVPyR|BEOjJ|M{[yOFY>
MCF7 NVHPepdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfFNE4xOS1zMECg{txO NX\4XFJoPDhiaB?= MYrMc4chT0l3ME2tPE4yPiCP MnfhNlI{OzZ{NE[=
MDA-MB-231 NYjJ[nVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjnfHcxNjBzLUGwNEDPxE1? M{P2RVQ5KGh? NEfkSGxNd2diR1m1NF0uQC5yOTDN NFLPZ44zOjN|NkK0Oi=>
U251 MlPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[wMlAyNTFyMDFOwG0> NX;kU|ZuPDhiaB?= MXfMc4chT0l3ME2tO{43PiCP MYCyNlM{PjJ2Nh?=
SF268 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrXNE4xOS1zMECg{txO NG\k[201QCCq NFT3VVFNd2diR1m1NF0uPy57MjDN NETFSpEzOjN|NkK0Oi=>
SF295 M4WwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX62c2gxOC5yMT2xNFAh|ryP MYm0PEBp NILmdJpNd2diR1m1NF0uQC5|MTDN M4DUWFIzOzN4MkS2
SF539 NIrQVG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULEeI5EOC5yMT2xNFAh|ryP Mk\BOFghcA>? MUTMc4chT0l3ME2tPE42QSCP MknrNlI{OzZ{NE[=
SNB75 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{mzelAvODFvMUCwJO69VQ>? NF;Gd3I1QCCq MnHOUI9oKEeLNUC9MVgvPThiTR?= NGTxSJYzOjN|NkK0Oi=>
SNB78 NXO1co9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HVc|AvODFvMUCwJO69VQ>? MlrBOFghcA>? MULMc4chT0l3ME2tPE43PSCP NEfm[FEzOjN|NkK0Oi=>
HCC2998 NVjkVI1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4naVlAvODFvMUCwJO69VQ>? MmTxOFghcA>? MlHzUI9oKEeLNUC9MVgvODViTR?= M4jCT|IzOzN4MkS2
KM12 NIHUNm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\LW2IxNjBzLUGwNEDPxE1? NH7FNJA1QCCq MljLUI9oKEeLNUC9MVcvPTRiTR?= M{[1NVIzOzN4MkS2
HT-29 NYLtN|d[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;1R|AvODFvMUCwJO69VQ>? NUG1RYxHPDhiaB?= MWLMc4chT0l3ME2tO{44PSCP MkXhNlI{OzZ{NE[=
HCT15 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jadVAvODFvMUCwJO69VQ>? M2rTTVQ5KGh? M{nsZ2xw\yCJSUWwQU05NjB|IF2= M4T3WlIzOzN4MkS2
HCT116 M1LMXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jwT|AvODFvMUCwJO69VQ>? MV60PEBp Mnr3UI9oKEeLNUC9MVcvPjFiTR?= Mkm2NlI{OzZ{NE[=
NCI-H23 NH7rd2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzOXGdROC5yMT2xNFAh|ryP NW[xT5l{PDhiaB?= MmmyUI9oKEeLNUC9MVcvPjRiTR?= NVS4ZlZxOjJ|M{[yOFY>
NCI-H226 M3X5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYWwMlAyNTFyMDFOwG0> MUO0PEBp NWP4WnE2VG:pIFfJOVA:NThwNESgUS=> NX;seIxHOjJ|M{[yOFY>
NCI-H522 Mn7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m1bFAvODFvMUCwJO69VQ>? NVjvZ3lsPDhiaB?= NEnKPYRNd2diR1m1NF0uQC52NTDN MVKyNlM{PjJ2Nh?=
NCI-H438 M320Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYSwMlAyNTFyMDFOwG0> MoXMOFghcA>? Ml;MUI9oKEeLNUC9MVgvOTFiTR?= NHnjTGgzOjN|NkK0Oi=>
A549 NWG1[XhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXqNE4xOS1zMECg{txO NUP2XHVwPDhiaB?= M17sTmxw\yCJSUWwQU05NjB5IF2= MV:yNlM{PjJ2Nh?=
DMS273 M1vtdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY[wMlAyNTFyMDFOwG0> NXLQVodKPDhiaB?= MY\Mc4chT0l3ME2tO{45OCCP NX:wc5NMOjJ|M{[yOFY>
DMS114 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHztTGUxNjBzLUGwNEDPxE1? NFjSZnM1QCCq MXLMc4chT0l3ME2tPE4{QSCP MXWyNlM{PjJ2Nh?=
LOXIMVI NG\iWoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fPWFAvODFvMUCwJO69VQ>? M{OxcFQ5KGh? MnTKUI9oKEeLNUC9MVgvPjZiTR?= NWWwdnh6OjJ|M{[yOFY>
OVCAR3 MknsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYiwMlAyNTFyMDFOwG0> NVjFO|RqPDhiaB?= NWf2RoNxVG:pIFfJOVA:NThwMUegUS=> NYW5XFF4OjJ|M{[yOFY>
OVCAR4 M{fXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPLRWFXOC5yMT2xNFAh|ryP M2PqNlQ5KGh? M1;TSmxw\yCJSUWwQU05NjV6IF2= MXqyNlM{PjJ2Nh?=
OVCAR5 NFq3O4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHlWXBTOC5yMT2xNFAh|ryP MkewOFghcA>? NWPCWIxNVG:pIFfJOVA:NTdwNUegUS=> NYrscpNWOjJ|M{[yOFY>
OVCAR8 NH3rbmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n3UlAvODFvMUCwJO69VQ>? M2KwNFQ5KGh? NF31W2hNd2diR1m1NF0uPy56NDDN M4HSd|IzOzN4MkS2
SKOV3 NVGxZ3V2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULmR2FOOC5yMT2xNFAh|ryP NHG3e3A1QCCq M2Twe2xw\yCJSUWwQU05NjRzIF2= NV\tZnFDOjJ|M{[yOFY>
RXF631L MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnkR|RlOC5yMT2xNFAh|ryP MUK0PEBp M{[ydGxw\yCJSUWwQU05NjJzIF2= MlrQNlI{OzZ{NE[=
ACHN M{G0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVGwMlAyNTFyMDFOwG0> NEDxbng1QCCq MlT4UI9oKEeLNUC9MVcvQTViTR?= NYnafW9POjJ|M{[yOFY>
St-4 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fDR|AvODFvMUCwJO69VQ>? MoruOFghcA>? MYrMc4chT0l3ME2tO{41PyCP NFTzSYwzOjN|NkK0Oi=>
MKN1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zOTlAvODFvMUCwJO69VQ>? M1H4O|Q5KGh? MlvQUI9oKEeLNUC9MVgvPDFiTR?= NHXL[VEzOjN|NkK0Oi=>
MKN7 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWSwMlAyNTFyMDFOwG0> NGHhPXI1QCCq NEDlcHRNd2diR1m1NF0uPy54ODDN M{L5S|IzOzN4MkS2
MKN28 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\uNE4xOS1zMECg{txO NWLme4pHPDhiaB?= NED6T5dNd2diR1m1NF0uPy5yNzDN NGi1XG0zOjN|NkK0Oi=>
MKN45 MkPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYCzbpJWOC5yMT2xNFAh|ryP MUm0PEBp MV;Mc4chT0l3ME2tPE4{PCCP MVKyNlM{PjJ2Nh?=
MKN74 MnjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOwMlAyNTFyMDFOwG0> MmD6OFghcA>? MmfpUI9oKEeLNUC9MVcvPDJiTR?= NGrUSIIzOjN|NkK0Oi=>
DU145 NVns[I46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDmU2QxOC5yMT2xNFAh|ryP MlnVOFghcA>? NHGySYVNd2diR1m1NF0uQC5zNjDN NFvmSZYzOjN|NkK0Oi=>
PC3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DGZ|AvODFvMUCwJO69VQ>? NXrHd|FZPDhiaB?= MmnkUI9oKEeLNUC9MVgvPjZiTR?= M{nzWVIzOzN4MkS2
Trypanosoma brucei brucei M364UWZ2dmO2aX;uJGF{e2G7 MoriNlAxKG6P MkPUNVIhcA>? M4W0[mROW09? MUjE[YNz\WG|ZTDpckBxcG:|cHjveIllgWxiaX7vd4l1d2xicHjvd5Bp[XSnIHzleoVt NFnLcJozPDhyNUm0Oi=>
Trypanosoma brucei brucei M{LTPGZ2dmO2aX;uJGF{e2G7 M{O4cVE5KGh? NFvOTlVFVVOR NW\yUHpQUW6qaXLpeIlwdiCxZjDy[YNmeHSxcj3t[YRq[XSnZDDlcoRw[3m2b4Ppd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjD0doFve2[ncoLpckB2eHSja3W= MWGyOFgxPTl2Nh?=
Trypanosoma brucei brucei NV71VG9ZTnWwY4Tpc44hSXO|YYm= M1H1ZlIxOCCwTR?= NGDMTnEyOiCq NGT0NG5FVVOR MWPF[oZm[3Rib36gd5BpcW6pb335cIVqdiCuZY\lcC=> MlXFNlQ5ODV7NE[=
Trypanosoma brucei brucei MWrGeY5kfGmxbjDBd5NigQ>? M4nnRVIxOCCwTR?= Mnz2NVIhcA>? NHzoOJlFVVOR M4\MR2Vn\mWldDDvckBxcG:|cHjheIllgWylaH;sbY5mKGyndnXs MYGyOFgxPTl2Nh?=
UM-UC-3 NIPpbHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HoS2lEPTB;M{G1JJBO NHPXZ4FUSU6JRWK=
SBC-1 MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXWR49KSzVyPUe0NkBxVQ>? MVHTRW5ITVJ?
MKN1 MojhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXxV2diUUN3ME2yMlghdk1? M1zSdXNCVkeHUh?=
NCI-H720 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPqTHlKUUN3ME2zMlU4KG6P M3i2PHNCVkeHUh?=
BFTC-909 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLiZ|NPUUN3ME2zMlcyKG6P NIrwNYxUSU6JRWK=
BPH-1 MmnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnJTWM2OD12Lke2JI5O MWTTRW5ITVJ?
PC-3 Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XSVmlEPTB;NT6wPUBvVQ>? MkKyV2FPT0WU
AN3-CA M{DyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTVwNU[gcm0> NVi0Sm9GW0GQR1XS
HN MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmezTWM2OD13Lkm2JI5O NVf6Z2JHW0GQR1XS
HCC2218 NVn4e5lMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjkVlVKSzVyPU[uOlEhdk1? MnPnV2FPT0WU
KP-4 NYqy[G1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PnbmlEPTB;NzDuUS=> MVHTRW5ITVJ?
LU-139 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLIPHhKSzVyPUeuO|chdk1? M{HDRXNCVkeHUh?=
ETK-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTdwOEigcm0> M2fzRnNCVkeHUh?=
Ramos-2G6-4C10 Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRThwNEmgcm0> NGLF[m9USU6JRWK=
MHH-PREB-1 M{LmTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\ReJZRUUN3ME25MlEzKG6P M175T3NCVkeHUh?=
DU-4475 M2m0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTpUnFGUUN3ME25MlQ1KG6P MlPuV2FPT0WU
NCI-H1666 Moe0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DoeWlEPTB;OT63NUBvVQ>? NEP2VGtUSU6JRWK=
CAMA-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvsUmVSUUN3ME25Mlghdk1? MlLqV2FPT0WU
TYK-nu MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLmS4JKSzVyPUmuPVQhdk1? NXPkNm5GW0GQR1XS
MFE-280 M2nGd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjFV5d[UUN3ME25Mlk6KG6P M3jKbHNCVkeHUh?=
A549 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDzTWM2OD1zMD6xOEBvVQ>? Mny2V2FPT0WU
769-P MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjTTWM2OD1zMD60OEBvVQ>? M1fhTnNCVkeHUh?=
L-363 MoHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:xNYR{UUN3ME2xNE43QSCwTR?= M4q1dXNCVkeHUh?=
ES8 MmjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfQe5JKSzVyPUGwMlkhdk1? NWXrNmZRW0GQR1XS
PA-1 NIX6fVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTFzLkiyJI5O M1\F[nNCVkeHUh?=
Mewo M3\JXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzGb2pKSzVyPUGxMlk6KG6P MVLTRW5ITVJ?
HSC-3 NGLQPYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7ue|FKSzVyPUGyMlIyKG6P MYfTRW5ITVJ?
H4 MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXPbXpxUUN3ME2xNk43PyCwTR?= M3fUd3NCVkeHUh?=
BB65-RCC NFO3WVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF{LkeyJI5O MlzHV2FPT0WU
NCI-H1793 NEj5U2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n1[WlEPTB;MUKuPFIhdk1? MkHMV2FPT0WU
KARPAS-45 MlTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HPNGlEPTB;MUOuOVEhdk1? M{jVRnNCVkeHUh?=
GCT NX[wNml2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPh[5BKSzVyPUGzMlY5KG6P NVGydW56W0GQR1XS
EoL-1 MoTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\zdWlEPTB;MUOuPVMhdk1? NXrDc49QW0GQR1XS
LB2241-RCC NF7DXlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zOS2lEPTB;MUSuNFEhdk1? NXXufo95W0GQR1XS
ES5 NXXvRYpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjKRolKSzVyPUG0Mlc1KG6P MX3TRW5ITVJ?
LOXIMVI NX36XlV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPDO41KSzVyPUG0Mlk6KG6P Mnr6V2FPT0WU
COR-L105 NH7yVnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2n4[WlEPTB;MUWuNFQhdk1? NXGy[2xLW0GQR1XS
P12-ICHIKAWA NHezeVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPtW5JKSzVyPUG1MlEhdk1? NXvPUJRUW0GQR1XS
CHL-1 NYT0fYl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX70ZZd5UUN3ME2xOU41PSCwTR?= Ml\UV2FPT0WU
VMRC-RCZ NXrmSY1lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3uTWM2OD1zNT62N{BvVQ>? MYnTRW5ITVJ?
HH M1;hZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTF3Lkegcm0> NIryWJhUSU6JRWK=
NUGC-3 NWPrbGxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\SOWlEPTB;MU[uN|Qhdk1? M3LWfXNCVkeHUh?=
EGI-1 NUPKTWJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPBNYlKSzVyPUG2MlQ{KG6P NXSwepViW0GQR1XS
OS-RC-2 Mn3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;vUWZKSzVyPUG2MlQ4KG6P MYrTRW5ITVJ?
MOLT-16 NGfXeHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXkOVRKSzVyPUG3MlE2KG6P MWrTRW5ITVJ?
NCI-H209 NF\4[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjVOplKSzVyPUG3MlI6KG6P MoDRV2FPT0WU
697 MlPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3ZTFNCUUN3ME2xO{41OyCwTR?= MoWzV2FPT0WU
D-56MG M4nOfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPaTWM2OD1zNz62PUBvVQ>? NHL4ZoFUSU6JRWK=
VA-ES-BJ MorCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTF5LkizJI5O MXXTRW5ITVJ?
EW-16 M3fS[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPtb4RKSzVyPUG4MlA1KG6P NWXNR5FpW0GQR1XS
HGC-27 M{DESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfOXW1KSzVyPUG4MlA3KG6P MVHTRW5ITVJ?
ES7 Moi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHvZVY1UUN3ME2xPE4xQSCwTR?= MlLCV2FPT0WU
HuH-7 M{K0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n4[2lEPTB;MUiuOEBvVQ>? M3qwcnNCVkeHUh?=
BCPAP NF;pOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfDZm82UUN3ME2xPE43PSCwTR?= M4LmfHNCVkeHUh?=
SW1710 NESwXJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF6LkeyJI5O MVLTRW5ITVJ?
IST-MEL1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPuSnlbUUN3ME2xPE44PyCwTR?= MYLTRW5ITVJ?
SF295 M4ThS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfGTWM2OD1zOD65N{BvVQ>? MVLTRW5ITVJ?
RPMI-7951 NUTnTmo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7SZ5JKSzVyPUG5MlI5KG6P MnfhV2FPT0WU
SF126 Mk\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPqTWM2OD1zOT60NUBvVQ>? M3;rcHNCVkeHUh?=
GAMG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTF7LkS4JI5O MYrTRW5ITVJ?
KNS-81-FD M{W3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnuTWM2OD1zOT61OEBvVQ>? NWL0XIJRW0GQR1XS
RT-112 Mlv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLrTWM2OD1zOT62OkBvVQ>? Ml33V2FPT0WU
DEL NUjOUmZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LvRWlEPTB;MkCuOFkhdk1? NEHK[ZVUSU6JRWK=
CGTH-W-1 NGnvbFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTJyLk[zJI5O NHL3NoVUSU6JRWK=
HOS NX;IOnVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXQS2RKSzVyPUKxMlA3KG6P M4\YV3NCVkeHUh?=
ES4 MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4O3OWlEPTB;MkGuNFghdk1? M1\mfHNCVkeHUh?=
RXF393 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJzLkS1JI5O MkmyV2FPT0WU
NCI-H2030 NUTKfI5UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P0Z2lEPTB;MkGuOVIhdk1? Mnj1V2FPT0WU
YH-13 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfBWGtKSzVyPUKxMlg5KG6P MX\TRW5ITVJ?
HT-1080 NVy5e5FQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTJzLkmzJI5O NHTD[ZVUSU6JRWK=
NCI-SNU-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j5U2lEPTB;MkGuPVUhdk1? M1;GO3NCVkeHUh?=
G-402 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrVTWM2OD1{Mj6xOkBvVQ>? MmDwV2FPT0WU
786-0 MkTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGGxTWdKSzVyPUKyMlI6KG6P NG\qWHlUSU6JRWK=
ME-180 MkK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJ{LkSzJI5O MYLTRW5ITVJ?
NB69 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJ{LkWzJI5O NFftdW9USU6JRWK=
J-RT3-T3-5 NHj6OJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\aU4JKSzVyPUKyMlk3KG6P MYjTRW5ITVJ?
TGBC1TKB M2PxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzhblNKSzVyPUKzMlA2KG6P MV7TRW5ITVJ?
SW780 NHv6[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3WXppKSzVyPUKzMlE{KG6P NWHsTm51W0GQR1XS
MG-63 MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXHVnVKSzVyPUKzMlQ2KG6P M2XuZXNCVkeHUh?=
BV-173 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[xTWM2OD1{Mz64O{BvVQ>? MVHTRW5ITVJ?
CAL-51 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXSTYk1UUN3ME2yN{45QSCwTR?= NEfq[JdUSU6JRWK=
A375 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjNTWM2OD1{Mz65N{BvVQ>? MlWzV2FPT0WU
MEL-HO NFW4N2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETENnlKSzVyPUK0MlA1KG6P MVrTRW5ITVJ?
EFO-27 NYj2eY06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLtfVZKSzVyPUK0MlM{KG6P NXzJXnMyW0GQR1XS
Hs-578-T M4juWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJ2LkW4JI5O NWPVZ49CW0GQR1XS
NBsusSR MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz1TWM2OD1{ND62JI5O NELHXJVUSU6JRWK=
CTB-1 M4HJZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJ2Lk[3JI5O NF3ESXBUSU6JRWK=
FTC-133 NGXmfoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJ3LkGgcm0> MX\TRW5ITVJ?
MOLT-4 M3nkPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUH6c29rUUN3ME2yOU4yOiCwTR?= M2G0SXNCVkeHUh?=
HO-1-N-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{H0XWlEPTB;MkWuNVUhdk1? NE\PRllUSU6JRWK=
ES3 MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJ3LkKyJI5O MkH3V2FPT0WU
TI-73 NUfmcpVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MomyTWM2OD1{NT6yPEBvVQ>? M4fqSXNCVkeHUh?=
MPP-89 NEPjRopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWm3VWR5UUN3ME2yOU4{OiCwTR?= NFvsXFdUSU6JRWK=
KYSE-150 NHi4SHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\jTWM2OD1{NT64PUBvVQ>? NHPoeWdUSU6JRWK=
LXF-289 NEniTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof4TWM2OD1{Nj6wOEBvVQ>? MWrTRW5ITVJ?
SK-LU-1 MmTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDvUmFyUUN3ME2yOk4yPyCwTR?= MlvqV2FPT0WU
HOP-92 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPL[4gyUUN3ME2yOk41QCCwTR?= MnvxV2FPT0WU
HuO9 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYP3bXJjUUN3ME2yOk44PiCwTR?= Mmn3V2FPT0WU
SW962 MkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTiOFBpUUN3ME2yOk44PiCwTR?= M2joVHNCVkeHUh?=
RS4-11 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PwdmlEPTB;Mk[uPVEhdk1? NVfD[FBCW0GQR1XS
NCI-H292 M1PZeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D5TGlEPTB;Mkegcm0> M2PPRnNCVkeHUh?=
DB NH\4RVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTJ5LkO2JI5O NUHSN2NyW0GQR1XS
SW1088 NGfMTFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M120RmlEPTB;MkiuNlkhdk1? NFPR[GlUSU6JRWK=
A204 M3;vVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfTTWM2OD1{OD60O{BvVQ>? NFHOXFZUSU6JRWK=
A3-KAW NH;NUVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJ6Lk[0JI5O NU[zfXpvW0GQR1XS
MV-4-11 NEH4VY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJ6Lkegcm0> M1L1TnNCVkeHUh?=
ES1 NHjiU|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJ6Lki0JI5O MlniV2FPT0WU
ONS-76 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJ7LkC1JI5O NHnIW5pUSU6JRWK=
D-263MG M2Dh[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDXPVdKSzVyPUK5MlM2KG6P NV7l[XNYW0GQR1XS
U-2-OS Mn7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf3TWM2OD1{OT61JI5O Mn:zV2FPT0WU
T98G MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ7Lki4JI5O NVLjc4hNW0GQR1XS
GI-ME-N NH7tNohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfuTWM2OD1{OT65NUBvVQ>? NEXY[W9USU6JRWK=
BHT-101 NXja[GV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTybYZCUUN3ME2zNE4xPSCwTR?= NGTnZmhUSU6JRWK=
NOS-1 NYW2VYd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknVTWM2OD1|MD6xNkBvVQ>? NXrDZZJHW0GQR1XS
AsPC-1 NHnRUHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTNyLkKgcm0> M2LmTnNCVkeHUh?=
QIMR-WIL NHnEO2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfSUIZWUUN3ME2zNE43KG6P MVnTRW5ITVJ?
JVM-3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfY[FhvUUN3ME2zNE45OyCwTR?= NVjSWZRbW0GQR1XS
KU-19-19 Ml3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL4fpM1UUN3ME2zNU4yOyCwTR?= NHG2fohUSU6JRWK=
OVCAR-8 NVfEN4hWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLJUoVKSzVyPUOxMlI3KG6P NUHhPHpJW0GQR1XS
BEN M3:xcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfhRWsyUUN3ME2zNU43OyCwTR?= M33rN3NCVkeHUh?=
BE-13 M{nXZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTNzLkiyJI5O MYrTRW5ITVJ?
EW-18 NF\SR5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z6Z2lEPTB;M{GuPFYhdk1? MYXTRW5ITVJ?
ECC10 M{LMeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETLdYJKSzVyPUOxMlk2KG6P MkG1V2FPT0WU
CTV-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFW0XWpKSzVyPUOyMlgzKG6P NUHieWFrW0GQR1XS
COLO-800 M1q1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXZc3ZKSzVyPUOyMlkzKG6P MUTTRW5ITVJ?
A2058 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3u2WGlEPTB;M{OuNlUhdk1? M1TzUnNCVkeHUh?=
VM-CUB-1 M{PiVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDGTWM2OD1|Mz60N{BvVQ>? MmLrV2FPT0WU
Ca9-22 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrSTWM2OD1|Mz61OUBvVQ>? MUPTRW5ITVJ?
COLO-684 MkDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTN|LkW4JI5O Mk\mV2FPT0WU
RPMI-8226 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTN|LkiyJI5O M4XvdnNCVkeHUh?=
SK-NEP-1 NIXhNmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTpTWM2OD1|ND6xOUBvVQ>? NFzmd5JUSU6JRWK=
Becker M4ixS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXUTWM2OD1|ND6yNUBvVQ>? NFe1UppUSU6JRWK=
NCI-H28 M{P4Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoCzTWM2OD1|ND60OEBvVQ>? MkS3V2FPT0WU
CAL-120 MmP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTN2LkeyJI5O MlvpV2FPT0WU
MDA-MB-157 NFTqV3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DhcWlEPTB;M{WuOFEhdk1? MnXMV2FPT0WU
OVCAR-5 NYm0eZBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPPTWM2OD1|NT60O{BvVQ>? MoPzV2FPT0WU
LAMA-84 NUnqdWlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[4OmlEPTB;M{WuPFchdk1? NHLHS5lUSU6JRWK=
CAKI-1 NFf0dHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTpTWM2OD1|Nj60N{BvVQ>? NEfSPVBUSU6JRWK=
Daoy M1K5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDFTWM2OD1|Nj63JI5O NGjwfXVUSU6JRWK=
CAL-62 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rmfWlEPTB;M{[uPFYhdk1? NHfYSGlUSU6JRWK=
8-MG-BA NFfScmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTN5LkK1JI5O M4jOW3NCVkeHUh?=
8505C NFjoXJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3ycnNKSzVyPUO3MlUyKG6P NVXT[npSW0GQR1XS
LNCaP-Clone-FGC MlTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzPbm5KSzVyPUO3MlU6KG6P Mnj6V2FPT0WU
CAL-39 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT4TWM2OD1|Nz65JI5O MlvVV2FPT0WU
MN-60 M1vJVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTN5Lkm2JI5O MoS0V2FPT0WU
RKO MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\3ZnNnUUN3ME2zPE4{OyCwTR?= NIDPbWlUSU6JRWK=
U251 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3yzO2lEPTB;M{iuOFMhdk1? NGnL[5ZUSU6JRWK=
SJSA-1 NYLRXW1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGG5[|JKSzVyPUO4MlU1KG6P MlXQV2FPT0WU
CAL-12T NXPae4dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH6TWM2OD1|OD62JI5O MkLlV2FPT0WU
HCC1419 MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{foN2lEPTB;M{iuO|Ehdk1? M3nhNnNCVkeHUh?=
CO-314 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTN6Lke0JI5O NFzuVJRUSU6JRWK=
LB1047-RCC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV21N291UUN3ME2zPE45OSCwTR?= M3X6NHNCVkeHUh?=
A101D M1HpPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXtVHN5UUN3ME2zPE46PyCwTR?= NY\2OGFTW0GQR1XS
MDA-MB-175-VII M1\aPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[yd3VKSzVyPUO5MlUyKG6P M4DJe3NCVkeHUh?=
MZ2-MEL M2XVTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr5TWM2OD1|OT62OkBvVQ>? NGjCUGVUSU6JRWK=
NB5 MnTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;x[mNQUUN3ME20NE43PCCwTR?= M3LrWnNCVkeHUh?=
G-401 NHfufFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3G1TGlEPTB;NECuPFIhdk1? MkT2V2FPT0WU
HT NFTCOINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPzTWM2OD12MT6wNkBvVQ>? NI\pbnBUSU6JRWK=
8305C NWPNUW9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPwTWM2OD12MT64O{BvVQ>? M{fs[HNCVkeHUh?=
BHY M4DKZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTR{LkeyJI5O M2Hrc3NCVkeHUh?=
NTERA-S-cl-D1 NIXGRXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjES5NoUUN3ME20N{BvVQ>? MXzTRW5ITVJ?
T-24 M1;BNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnuR5dKSzVyPUSzMlg{KG6P NXvndZZ6W0GQR1XS
EPLC-272H M2W5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzldpJKSzVyPUS0MlM6KG6P Mn7LV2FPT0WU
PSN1 MlO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTR2LkSgcm0> NEm5[W1USU6JRWK=
NCI-H2452 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfnNYVKSzVyPUS0MlU5KG6P NVPEdHpJW0GQR1XS
KS-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTR2Lk[2JI5O M4XKOHNCVkeHUh?=
HD-MY-Z NUPGSYFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\Uc2VKSzVyPUS0MlkzKG6P Mn34V2FPT0WU
KNS-62 NGTZT5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTuTWM2OD12NT6zPEBvVQ>? NGftfHpUSU6JRWK=
NOMO-1 NFO0TWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe0TWM2OD12NT64O{BvVQ>? MnPQV2FPT0WU
SK-HEP-1 NFzWc5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTR4LkC0JI5O NIDabIJUSU6JRWK=
IGR-1 NGPm[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFiwWG5KSzVyPUS2MlE{KG6P M2r0d3NCVkeHUh?=
KYSE-180 NV62cHNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jYcWlEPTB;NE[uNVchdk1? NIfLVZBUSU6JRWK=
EW-22 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnUTWM2OD12Nj6yJI5O NV\iZXlRW0GQR1XS
NCI-H1355 NF;rW2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7JOGNKSzVyPUS2MlM1KG6P M2jlO3NCVkeHUh?=
DOHH-2 NXLUOY9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTR4LkO3JI5O NGHxOolUSU6JRWK=
A4-Fuk MoPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3W1XmlEPTB;NE[uOVIhdk1? MnntV2FPT0WU
PC-14 Mnq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\UPYV5UUN3ME20Ok42PyCwTR?= NEnsNI9USU6JRWK=
TE-5 MmnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDnfplKSzVyPUS2Mlg1KG6P NX\r[G9IW0GQR1XS
LB996-RCC NVjxSVhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTR5LkG5JI5O M4fnbXNCVkeHUh?=
NCI-H1623 M16zb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K3[GlEPTB;NEeuO|Yhdk1? NF;1fJdUSU6JRWK=
NCI-H1155 M3XEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfVTWM2OD12OD6zNkBvVQ>? M{HwOXNCVkeHUh?=
LoVo Mlr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEP0dYxKSzVyPUS4MlQhdk1? MX;TRW5ITVJ?
MCF7 NUflbZduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XYTWlEPTB;NEiuOVghdk1? NIHFe3lUSU6JRWK=
AGS Ml3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXpb|ZkUUN3ME20PE44PyCwTR?= NVLufZZCW0GQR1XS
PFSK-1 MoDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33vXWlEPTB;NEmuNFYhdk1? MmXYV2FPT0WU
22RV1 M4HaVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTR7LkC5JI5O NFnXdGhUSU6JRWK=
COR-L23 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrCTWM2OD12OT6xOkBvVQ>? NXrWb5hEW0GQR1XS
D-283MED NEezeWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTR7Lk[xJI5O NUDReGFpW0GQR1XS
SW982 MkTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nsc2lEPTB;NEmuPVEhdk1? NGW2eWtUSU6JRWK=
SW620 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrNTWM2OD13MD6zOkBvVQ>? MmnWV2FPT0WU
KYSE-140 NX:3d4RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[ybVNZUUN3ME21NE42PSCwTR?= MVTTRW5ITVJ?
GCIY NUPRcWozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzu[29CUUN3ME21NE43PyCwTR?= NV7uSoZSW0GQR1XS
MHH-ESS-1 NEWwOoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\hTWM2OD13MT65OUBvVQ>? M1;4OHNCVkeHUh?=
D-423MG MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHm3OXlKSzVyPUWyMlA5KG6P MXzTRW5ITVJ?
SF539 M2nKU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHFT5BKSzVyPUWyMlM2KG6P MkC1V2FPT0WU
RPMI-2650 MmL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzNTWM2OD13Mj62PUBvVQ>? M13qPHNCVkeHUh?=
GR-ST NGKyRnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;mTWM2OD13Mj64O{BvVQ>? M1PmWHNCVkeHUh?=
YKG-1 M{jifmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV22e2lyUUN3ME21N{BvVQ>? M2fhcnNCVkeHUh?=
SK-MES-1 M3uxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzyTWM2OD13Mz6yOkBvVQ>? NULuenJQW0GQR1XS
HLE MkjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjmTWM2OD13Mz60O{BvVQ>? M4DvPXNCVkeHUh?=
RVH-421 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\mOnhzUUN3ME21N{43PyCwTR?= Ml\FV2FPT0WU
C32 MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrWTVBrUUN3ME21N{45OyCwTR?= NIfEWW9USU6JRWK=
GB-1 NHzKe2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfFTWM2OD13ND6yJI5O M3H0TXNCVkeHUh?=
SNB75 NH20b4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknRTWM2OD13ND6yOkBvVQ>? M2TJXHNCVkeHUh?=
EM-2 M4HNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjONmNKSzVyPUW0MlQhdk1? NWTLNWdXW0GQR1XS
RH-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWqydXRsUUN3ME21OE44KG6P M4XTOXNCVkeHUh?=
NKM-1 M2KxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTV2LkixJI5O MmPpV2FPT0WU
NCI-H2405 M1Gwdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTV2Lki4JI5O MWXTRW5ITVJ?
KYSE-450 NWLUUZR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTV3LkG2JI5O MoTNV2FPT0WU
A704 NIja[nVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrKTWM2OD13NT61PUBvVQ>? NVnyPI1nW0GQR1XS
HAL-01 NXi4UnV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTV3LkizJI5O MnPvV2FPT0WU
TE-11 MoP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvlTWM2OD13NT65PUBvVQ>? Mk\RV2FPT0WU
DOK Ml3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjsVWNKSzVyPUW2MlAzKG6P M2rzPXNCVkeHUh?=
KY821 M4LobWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfoWpBsUUN3ME21Ok4zKG6P MUnTRW5ITVJ?
KGN M4PnWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVn2ZmRTUUN3ME21Ok4{OiCwTR?= MYXTRW5ITVJ?
MC116 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTV5Lkigcm0> MnjUV2FPT0WU
PANC-08-13 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTV6LkCxJI5O Ml\KV2FPT0WU
KE-37 M{Hxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTV6Lke3JI5O M{O2e3NCVkeHUh?=
KYSE-410 MoTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLJZZAxUUN3ME21PU41PyCwTR?= MkPMV2FPT0WU
RO82-W-1 NXzQSHlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHvZohpUUN3ME21PU46KG6P M{jOTHNCVkeHUh?=
M14 M175T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTZyLkC0JI5O MmLtV2FPT0WU
GI-1 NFfD[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;hTWM2OD14MD6zJI5O M3HqPXNCVkeHUh?=
ML-2 Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDBXXpOUUN3ME22NE43OiCwTR?= M2TZdnNCVkeHUh?=
BFTC-905 MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTZyLk[1JI5O MUHTRW5ITVJ?
DMS-273 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnZTWM2OD14MD64O{BvVQ>? NVfxbFFuW0GQR1XS
MDA-MB-361 MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULO[oJxUUN3ME22NUBvVQ>? M1jvcHNCVkeHUh?=
MSTO-211H MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLMTWM2OD14Mz61NUBvVQ>? MWXTRW5ITVJ?
MEG-01 NWPrZXAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjhUodsUUN3ME22N{42OiCwTR?= Ml:yV2FPT0WU
M059J MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;JNWVPUUN3ME22N{42QCCwTR?= NVTFTopNW0GQR1XS
LN-405 M{TWWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq0XGhKSzVyPU[zMlg2KG6P NUHIZW9FW0GQR1XS
NCI-H1581 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPndFhUUUN3ME22OE4xOyCwTR?= NGC2RXhUSU6JRWK=
TCCSUP MnzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTS[2Y3UUN3ME22OE42OyCwTR?= NVPaTodsW0GQR1XS
SW872 NYr1d45UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2P6ZWlEPTB;NkSuOVchdk1? NIXLTJFUSU6JRWK=
KYSE-510 MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrDfo5KSzVyPU[1Mlc2KG6P NVL1N|hTW0GQR1XS
NCI-H1792 NUK4d|RMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln0TWM2OD14Nj6xOUBvVQ>? NIDrdJlUSU6JRWK=
SW13 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7LOlNnUUN3ME22Ok42KG6P NV\wRXJJW0GQR1XS
TE-8 NYnmXJlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXKO2lQUUN3ME22Ok42OiCwTR?= NXL4[4pRW0GQR1XS
SCH M1rQSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTZ5LkGgcm0> MmXLV2FPT0WU
NEC8 NWfqSnpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVOzTHZxUUN3ME22O{4zPCCwTR?= NYHLZY02W0GQR1XS
HuO-3N1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi0TWM2OD14Nz6zNUBvVQ>? NXPpVoh3W0GQR1XS
EFM-19 Mmj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmeyTWM2OD14Nz61JI5O M3PhOXNCVkeHUh?=
HEC-1 Mlv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfGVY1ZUUN3ME22O{42OiCwTR?= M1m1V3NCVkeHUh?=
T47D NFmzZ3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTZ5Lki3JI5O NI\jPYxUSU6JRWK=
SNU-423 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M363R2lEPTB;NkeuPVghdk1? NVXo[IM{W0GQR1XS
WM-115 NGTqdnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIS2ZYRKSzVyPU[4MlE1KG6P NFW5[mZUSU6JRWK=
CaR-1 MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrrTWM2OD14OD6yOUBvVQ>? M1WwOXNCVkeHUh?=
KU812 MonoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\lTWM2OD14OD62PUBvVQ>? MUPTRW5ITVJ?
AM-38 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\6c5ZyUUN3ME22PU4{OSCwTR?= NVrnbY17W0GQR1XS
KOSC-2 MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorhTWM2OD14OT65O{BvVQ>? NGrXco1USU6JRWK=
MC-IXC MnKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\hPWZTUUN3ME23NE4xQCCwTR?= MX\TRW5ITVJ?
SCC-4 MorDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3hTWM2OD15MT6zPEBvVQ>? Mm\HV2FPT0WU
Calu-3 NUDH[IhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2C1cGlEPTB;N{GuPVghdk1? NH3V[ZhUSU6JRWK=
RPMI-8866 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP0SlFKSzVyPUeyMlgzKG6P MVTTRW5ITVJ?
OVCAR-4 MoPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTd|LkO2JI5O MWHTRW5ITVJ?
OAW-42 M1nKN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXPO3d1UUN3ME23N{4{QSCwTR?= NEXtU2RUSU6JRWK=
ATN-1 NVn2fng6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH2TWM2OD15Mz64O{BvVQ>? MV3TRW5ITVJ?
CHP-212 NITIfZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HoZmlEPTB;N{SuPVUhdk1? NXT5[Gc6W0GQR1XS
C2BBe1 M1;sWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3flTWlEPTB;N{WuNFMhdk1? NVLodVFyW0GQR1XS
A498 M4[ze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPYeXpWUUN3ME23OU4yPSCwTR?= Mli0V2FPT0WU
SH-4 M1rMOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInjbXJKSzVyPUe1MlIyKG6P Ml24V2FPT0WU
SNU-449 NV[1bWJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TwO2lEPTB;N{WuO|khdk1? NVvO[ZY5W0GQR1XS
RD M2PUR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPZTWM2OD15NT64OkBvVQ>? NH7H[HRUSU6JRWK=
PANC-03-27 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPxenpKSzVyPUe2MlI2KG6P NU\DT4tnW0GQR1XS
S-117 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGWyeYZKSzVyPUe2MlI4KG6P NWDnUJJ4W0GQR1XS
SK-MEL-2 MnvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjQd4xKSzVyPUe2Mlc2KG6P MXrTRW5ITVJ?
LK-2 NETMPYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\idmk1UUN3ME23O{4xPSCwTR?= NYnOcVdXW0GQR1XS
CP50-MEL-B NEK1NHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\sVmlEPTB;N{euOEBvVQ>? NWq2dJVjW0GQR1XS
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NCI-H358 M4\lS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK1foZKSzVyPUGuPVU2ODNizszN MXjTRW5ITVJ?
OAW-28 M1SxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnYWYpwUUN3ME2yMlA3QTF7IN88US=> NEjNU3BUSU6JRWK=
C8166 M4jIUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrGTWM2OD1{Lk[zN|kzKM7:TR?= MXTTRW5ITVJ?
COLO-678 NHXYSWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDYbGp5UUN3ME2yMlg{PzZ6IN88US=> MnS0V2FPT0WU
SK-N-DZ MnX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJwOE[zPFEh|ryP NX\adWxRW0GQR1XS
NCI-H82 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rCO2lEPTB;Mj65NFM3QSEQvF2= NHTHZmxUSU6JRWK=
JVM-2 NVm2WYhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTNwMEOxPFgh|ryP MYPTRW5ITVJ?
SW1116 MkjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFW5eJlKSzVyPUOuNFU1OTFizszN M{LR[HNCVkeHUh?=
MDA-MB-453 MkHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vQT2lEPTB;Mz6xNFQ{QSEQvF2= NHLsNJhUSU6JRWK=
Calu-6 M2jjR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTrO4VKSzVyPUOuNVk6PyEQvF2= M2fBc3NCVkeHUh?=
SHP-77 Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTNwNUK4JO69VQ>? NIPaNIZUSU6JRWK=
Capan-2 NITDXpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvKbmlKSzVyPUSuN|I2QDFizszN MnPJV2FPT0WU
SW948 M2DSXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTRwN{S3O|kh|ryP M2LhWXNCVkeHUh?=
HDLM-2 NW\kdJpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXk[pR2UUN3ME21MlA4PzJ3IN88US=> NH3zRoZUSU6JRWK=
LAN-6 NYnvc49kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrONZpYUUN3ME22MlIyPDl3IN88US=> MlXhV2FPT0WU
LU-135 NYr1XXhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\SfJJKSzVyPU[uOFMxPzdizszN M2GxcHNCVkeHUh?=
T84 NFrueGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzVXIFiUUN3ME22Mlk5PjRizszN Mo\5V2FPT0WU
CAPAN-1 NXm2PHZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln5TWM2OD15Lk[yNlM{KM7:TR?= MlnDV2FPT0WU
SW1417 NGnHVIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTETWM2OD15LkmxO|MyKM7:TR?= M{T3enNCVkeHUh?=
BALL-1 M2TPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlO3TWM2OD16LkWwOFA6KM7:TR?= NYXhcGpNW0GQR1XS
HT-29 NGCz[FVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjXTWM2OD17LkC3OVk6KM7:TR?= M2fTZnNCVkeHUh?=
C3A NYTZOJZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Pk[GlEPTB;OT64PFM6PCEQvF2= M2TrUHNCVkeHUh?=
NCI-H1993 M4nPTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;EV2lEPTB;MUCuOVA5OSEQvF2= NWTuTpN{W0GQR1XS
SK-MEL-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTVcm1DUUN3ME2xNU43Ojh7IN88US=> NWDMcopSW0GQR1XS
DU-145 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTF2LkWwOVIh|ryP M2\ST3NCVkeHUh?=
KP-N-YN NWjsW29nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zURWlEPTB;MUSuOVExOyEQvF2= NVr0eXNVW0GQR1XS
CCRF-CEM NWnadIlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTF2Lke4NFkh|ryP NETDT3RUSU6JRWK=
ZR-75-30 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mln0TWM2OD1zNj6zN|A{KM7:TR?= M1\sSXNCVkeHUh?=
A673 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTJyLkW1NFch|ryP MVPTRW5ITVJ?
K-562 M3r0eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3LZnU4UUN3ME2yPE41OTh|IN88US=> MkjyV2FPT0WU

... Click to View More Cell Line Experimental Data
体内研究 BEZ235诱导肿瘤(69%)消退，而对体重增加没有统计学上显著的作用。总之，这些初步的体内功效研究结果表明，BEZ235单一口服给药时能够阻断疾病的发展，与其他抗癌药结合使用时能够增强疗效。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验：

[2]
+ 展开

体外蛋白激酶,PI3K,和mTOR实验:

PI3Kα, β, δ蛋白都由与p110全长蛋白相接的p85 N端的iSH2域组成，只是PI3Kα没有最后的20个氨基酸。PI3Kγ由p110全长蛋白去掉前144个氨基酸产生而来。所有PI3K蛋白在羧基末端加组氨酸标签便于纯化，然后克隆到pBlue-Bac4.5 (用于α, β,和δ亚型) 或者pVL1393 (用于γ 亚型) 质粒中。转染BaculoGold WT基因组DNA的不同的载体按说明书推荐的方法生产各自重组体杆状病毒及重组蛋白。使用激酶发光检测试剂盒测定BEZ235 (NVP-BEZ235)作用于PI3K的活力。在384孔板上进行激酶实验。在每个孔中加入50 nl的测试项目（溶在90%DMSO中）和5ul的反应buffer,反应buffer包含10 μg/ml PI基质 (l-α-磷脂酰肌醇; 由Avanti Polar Lipids提供;预备在3%辛基葡萄糖苷中)，然后加入PI3K 蛋白(p110α, p110β, p110δ,和p110γ分别为10, 25, 10,和150 nM)。加入预备在反应buffer中的5 ul 1 µM 的ATP反应开始，反应进行60分钟 (测p110α, p110β, p110δ)或者120分钟(测p110γ)，随后加入10ul的荧光激酶buffer终止反应。数据用Synergy 2 阅读器阅读用于荧光测试。
细胞实验：

[1]
+ 展开
  • Cell lines: HCT116, DLD-1, SW480
  • Concentrations: 0-1 μM
  • Incubation Time: 48小时
  • Method:

    HCT116 (PIK3CA突变型; 激酶域在H1047R), DLD-1 (PIK3CA突变型；螺旋域在E545K), SW480 (PIK3CA 野生型)人类CRC细胞系，同基因型的DLD-1 PIK3CA突变和野生型细胞培养在含10%FBS和1×青霉素/链霉素的培养基中。细胞按不同的初始密度加入（HCT116: 3000个细胞/每孔, DLD-1: 5500个细胞/每孔, SW480: 4500个细胞/每孔, DLD-1 PIK3CA突变型: 7000个细胞/每孔, DLD-1 PIK3CA野生型: 9000个细胞/每孔)，用来计算不同的生长动力学。16个小时后，细胞加入浓度越来越高的BEZ235中进行温育，含有药物的培养基24小时更换一次。根据产品说明书，加入细胞16小时和药物处理48小时，使用单溶液细胞增殖检测试剂盒以比色法检测细胞活力。与没有用药物处理正在生长的细胞相比，药物处理的细胞的活力也逐渐趋于正常化。使用GraphPad Prism 5软件用4个参数的回归曲线计算IC50值。用于western blot 分析，细胞用0 nM 或者最高抑制剂量(500 nM) BEZ235处理 2, 6, 24, 或者48 小时。


    (Only for Reference)
动物实验：

[2]
+ 展开
  • Animal Models: 雌性Harlan无胸腺裸鼠
  • Formulation: NMP/聚乙二醇300(10/90,v/v)
  • Dosages: 45 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用：
NMP+polyethylene glycol 300 (10+90, v+v) 		30 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 469.55
化学式

C30H23N5O
CAS号 915019-65-7
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00620594 Completed Breast Cancer|Advanced Solid Tumors|Cowden Syndrome Novartis Pharmaceuticals|Novartis December 21, 2006 Phase 1
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Patients. Charles Ryan|Novartis Pharmaceuticals|University of California, San Francisco January 2013 Phase 1|Phase 2
NCT01658436 Completed Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis November 2012 Phase 2
NCT01628913 Terminated Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis October 2012 Phase 2
NCT01690871 Withdrawn Malignant PEComa (Perivascular Epithelioid Cell Tumors) Novartis Pharmaceuticals|Novartis September 2012 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1：

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • 回答：

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

selleck catalog

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

相关PI3K产品

  • Taselisib (GDC 0032) New

    Taselisib (GDC 0032)是一种有效，下一代的β亚型PI3K抑制剂，作用于PI3Kα/δ/γ， IC50分别为0.29 nM/0.12 nM/0.97nM，比作用于PI3Kβ选择性高10倍以上。

  • Pilaralisib (XL147) New

    Pilaralisib (XL147)是一种选择性的可逆I型PI3K抑制剂，作用于PI3Kα/δ/γ，在无细胞试验中IC50为 39 nM/36 nM/23 nM，对PI3Kβ作用较低。Phase 1/2。

  • GNE-317 New

    GNE-317 是一种有效的，大脑渗透性 PI3K 抑制剂。

  • LY294002

    LY294002 是首个合成的已知抑制PI3Kα/δ/β的小分子，在无细胞测定中IC50分别为 0.5 μM/0.57 μM/0.97 μM；在溶液中比在Wortmannin中稳定，也能够阻断自噬体的形成。它不仅能够结合class I PI3Ks和其他PI3K相关的激酶，还能够结合一些与PI3K家族无关的新型靶点。

    Features:LY294002是选择性的, 可渗透细胞的特定PI3K抑制剂，可作用于酶的ATP结合位点，且抑制自体吞噬的螯合作用。

  • 3-Methyladenine (3-MA)

    3-Methyladenine (3-MA)是一种选择性PI3K抑制剂，作用于Vps34和PI3Kγ，在 HeLa细胞中IC50分别为25 μM和60 μM；永久性抑制I型PI3K，但对III型PI3K的抑制是短暂的，也会阻断自噬体的形成。

  • Idelalisib (CAL-101, GS-1101)

    Idelalisib (CAL-101, GS-1101) 是选择性p110δ抑制剂，在无细胞试验中IC50为 2.5 nM；对 p110δ 表现出的选择性是对 p110α/β/γ 的 40 到 300 倍，对p110δ的选择性是对 C2β，hVPS34，DNA-PK 和 mTOR的400到4000倍。

    Features:Calistoga 暗示 CAL-101治疗血液恶性肿瘤可能有更广泛的应用价值。

  • Wortmannin

    Wortmannin是一种首次命名的PI3K抑制剂，在无细胞试验中IC50为3 nM，对 PI3K 家族的选择性较低。也会抑制自噬体的形成，并有效抑制DNA-PK/ATM，在无细胞试验中IC50为16 nM和150 nM。

  • Buparlisib (BKM120, NVP-BKM120)

    Buparlisib (BKM120, NVP-BKM120) 是一种选择性 PI3K 抑制剂，在无细胞试验中作用于p110α/β/δ/γ的IC50分别为 52 nM/166 nM/116 nM/262 nM。对 VPS34，mTOR，DNAPK 的作用效果下降，而对 PI4Kβ几乎没有活性。Phase 2。

    Features:BKM120是可用于口服的生物有效的PI3K抑制剂。

  • Pictilisib (GDC-0941)

    Pictilisib (GDC-0941) 是一种有效的PI3Kα/δ抑制剂，在无细胞试验中IC50为 3 nM，对p110β (11倍)和p110γ (25倍)具有适度的选择性。Phase 2。

  • Alpelisib (BYL719)

    Alpelisib (BYL719) 是一种有效的选择性PI3Kα抑制剂，在无细胞试验中IC50为 5 nM，对PI3Kβ/γ/δ具有极弱的作用。Phase 2。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID