Dactolisib (BEZ235, NVP-BEZ235)

目录号:S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Phase 2。

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RMB 1414.41 现货
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客户购买Selleck的此次产品后发表的文献83篇:

客户使用该产品的11个实验数据:

  • Level of phospho-proteins in RTK and PI3K–Akt–mTOR pathways in treated tumours, detected with western blot.

    Nature, 2017, 728-732. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • (B) The effects of AZD2014, BEZ235, lapatinib, LEE011, pazopanib on PI3K/AKT signaling in sarcoma PDC line were determined by immunoblotting analysis. Cells were treated with 1 μM of the indicated drugs for 72 h.

    Transl Oncol, 2016, 9(3):197-202. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    The effects of LY294002, rapamycin and NVP-BEZ235 on activation of PI3K-Akt-mTOR pathway in hepatocytes. (a) The mRNA expression (PI3K, Akt, mTOR, raptor) by Real-Time PCR, (b) protein expression (PI3K, Akt, mTOR, S6K) by ELISA kits; (c) protein expression of S6K and P-S6K by western blotting. The different letters indicated significant differences (P <0.05). LY = LY294002; rapa = rapamycin; NVP = NVP-BEZ235.

    Animal, 2016, 10(8):1319-27. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Phase 2。
靶点
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
体外研究

BEZ235显著降低mTOR活化的激酶p70S6K的磷酸化水平。BEZ235导致S235/S236P-RPS6水平减少,IC50为6.5 nM。BEZ235抗mTOR的活性使用生化mTOR K-LISA试验测定,IC50为20.7 nM。BEZ235对其β旁系同源物的活性稍弱,IC50为75 nM。在人肿瘤细胞中,PI3K/Akt/mTOR通路经常被组成性活化。BEZ235阻断PI3K和mTOR激酶活性,通过结合于这些酶的ATP结合槽发挥作用。用逐渐增加浓度BEZ235处理PTEN-null细胞系PC3M和U87MG时,导致细胞增殖剂量依赖性减少,平均GI50为10-12 nM。[1] BEZ235是一种mTORC1/2催化抑制剂。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MkftRY51cW2rY4LvZolidCCDc4PhfS=> M3zXXVE5KGh? NF\GNGpFVVOR Mn\ORY51cXS{eYDhco9{d22jbDDhZ5Rqfmm2eTD3bZRpKEWFNUCgc4YhOC5yMEK1JO69VQ>? M1zqb|I1QDB3OUS2
MCF7 NWrKXnN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrjNE4xOS1zMECg{txO NFH2RWo1QCCq MV;EUXNQ NVHUPXRkUUN3ME2wMlc{KM7:TR?= NHv5VmkzOzh5MUmwOC=>
HCT116 MofMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXKwMlAyNTFyMDFOwG0> Mn7JOFghcA>? M2n2dGROW09? M4nofmlEPTB;MT6xOkDPxE1? MmPBNlM5PzF7MES=
U87MG NUTtcGM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3G0[lAvODFvMUCwJO69VQ>? NI\3T3c1QCCq MYLEUXNQ M1;zeWlEPTB;MT6zNkDPxE1? Ml;oNlM5PzF7MES=
HBC4 NYfu[5JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYCwMlAyNTFyMDFOwG0> MY[0PEBp M1rQdWxw\yCJSUWwQU05NjZzIF2= Mn;sNlI{OzZ{NE[=
BSY1 M1nqdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorKNE4xOS1zMECg{txO MUm0PEBp MXrMc4chT0l3ME2tPE41QCCP MoX0NlI{OzZ{NE[=
HBC5 NInBVVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVWwMlAyNTFyMDFOwG0> MVq0PEBp Mk\4UI9oKEeLNUC9MVcvQDdiTR?= MYOyNlM{PjJ2Nh?=
MCF7 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHVNE4xOS1zMECg{txO M2HuXVQ5KGh? NUXwXGREVG:pIFfJOVA:NThwMU[gUS=> M322RVIzOzN4MkS2
MDA-MB-231 NYXYeIpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:wMlAyNTFyMDFOwG0> NYS3XGJxPDhiaB?= M{LTRWxw\yCJSUWwQU05NjB7IF2= MX[yNlM{PjJ2Nh?=
U251 NHXUOI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrtNE4xOS1zMECg{txO NXvnd|Z{PDhiaB?= NFnVfoFNd2diR1m1NF0uPy54NjDN MXKyNlM{PjJ2Nh?=
SF268 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkW0NE4xOS1zMECg{txO NUC5NXI3PDhiaB?= NYXSb5oyVG:pIFfJOVA:NTdwOUKgUS=> MUeyNlM{PjJ2Nh?=
SF295 MkLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nlRlAvODFvMUCwJO69VQ>? NIDCWII1QCCq NYD1eVRkVG:pIFfJOVA:NThwM{GgUS=> M3X0VlIzOzN4MkS2
SF539 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH5R3MxNjBzLUGwNEDPxE1? NWjzepdEPDhiaB?= MlW0UI9oKEeLNUC9MVgvPTliTR?= NF\nd4EzOjN|NkK0Oi=>
SNB75 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVSwMlAyNTFyMDFOwG0> M4HMVFQ5KGh? NILC[IRNd2diR1m1NF0uQC53ODDN NF2wSVgzOjN|NkK0Oi=>
SNB78 NXrmeJFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jBblAvODFvMUCwJO69VQ>? MlnJOFghcA>? MY\Mc4chT0l3ME2tPE43PSCP NIrZNZMzOjN|NkK0Oi=>
HCC2998 MnfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X1OlAvODFvMUCwJO69VQ>? M1:4cVQ5KGh? MWDMc4chT0l3ME2tPE4xPSCP MWCyNlM{PjJ2Nh?=
KM12 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUToTFM5OC5yMT2xNFAh|ryP M1u2[VQ5KGh? M3SyVmxw\yCJSUWwQU04NjV2IF2= NGfRRXczOjN|NkK0Oi=>
HT-29 M{LmfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ruSVAvODFvMUCwJO69VQ>? NVzr[5hWPDhiaB?= NXXqRWJIVG:pIFfJOVA:NTdwN{WgUS=> MW[yNlM{PjJ2Nh?=
HCT15 MljtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDPNE4xOS1zMECg{txO MnO5OFghcA>? MofEUI9oKEeLNUC9MVgvODNiTR?= NIfC[oEzOjN|NkK0Oi=>
HCT116 M3PMZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGqx[5YxNjBzLUGwNEDPxE1? NYTZU3R2PDhiaB?= NULqe2hQVG:pIFfJOVA:NTdwNkGgUS=> MlTENlI{OzZ{NE[=
NCI-H23 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH4NE4xOS1zMECg{txO MkewOFghcA>? NUW5UXFQVG:pIFfJOVA:NTdwNkSgUS=> NH\FWlMzOjN|NkK0Oi=>
NCI-H226 NXr5U4d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\oRlAvODFvMUCwJO69VQ>? NH3oSnU1QCCq M3nqcmxw\yCJSUWwQU05NjR2IF2= M1rKVlIzOzN4MkS2
NCI-H522 Mlf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vNOVAvODFvMUCwJO69VQ>? M3\FdlQ5KGh? NYXVdJZTVG:pIFfJOVA:NThwNEWgUS=> NXnP[FB4OjJ|M{[yOFY>
NCI-H438 NWP1fVFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXKwMlAyNTFyMDFOwG0> MWW0PEBp NWLqeJc5VG:pIFfJOVA:NThwMUGgUS=> NI\NR|EzOjN|NkK0Oi=>
A549 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHj[JhsOC5yMT2xNFAh|ryP M{nCWFQ5KGh? M2jkW2xw\yCJSUWwQU05NjB5IF2= M1LuN|IzOzN4MkS2
DMS273 MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDiNE4xOS1zMECg{txO NYHyNXE1PDhiaB?= M4Xs[Gxw\yCJSUWwQU04NjhyIF2= M4rs[VIzOzN4MkS2
DMS114 Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLWNE4xOS1zMECg{txO MnHhOFghcA>? M3XGcWxw\yCJSUWwQU05NjN7IF2= NUT0dJV7OjJ|M{[yOFY>
LOXIMVI MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTJ[lF{OC5yMT2xNFAh|ryP MVm0PEBp M2PuWGxw\yCJSUWwQU05NjZ4IF2= M1;4SVIzOzN4MkS2
OVCAR3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVWwMlAyNTFyMDFOwG0> M1nuW|Q5KGh? NVTF[GZvVG:pIFfJOVA:NThwMUegUS=> M{fSUlIzOzN4MkS2
OVCAR4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWCwMlAyNTFyMDFOwG0> NWjoPXF7PDhiaB?= MWHMc4chT0l3ME2tPE42QCCP NX3GcWRjOjJ|M{[yOFY>
OVCAR5 M2nKWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;5cpBJOC5yMT2xNFAh|ryP NITHXXU1QCCq M2XsTmxw\yCJSUWwQU04NjV5IF2= NVjLOnNlOjJ|M{[yOFY>
OVCAR8 NVTLRVJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r2RVAvODFvMUCwJO69VQ>? NUHsXIZ7PDhiaB?= Mlq5UI9oKEeLNUC9MVcvQDRiTR?= Ml3TNlI{OzZ{NE[=
SKOV3 NF6wWpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLaNo1GOC5yMT2xNFAh|ryP NEG5dI01QCCq M33lR2xw\yCJSUWwQU05NjRzIF2= MUOyNlM{PjJ2Nh?=
RXF631L MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVywMlAyNTFyMDFOwG0> MoDNOFghcA>? NE\HVVhNd2diR1m1NF0uQC5{MTDN M4LpNFIzOzN4MkS2
ACHN NISyWHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmewNE4xOS1zMECg{txO MoTOOFghcA>? NU\FfIhXVG:pIFfJOVA:NTdwOUWgUS=> M2KydVIzOzN4MkS2
St-4 M4\GN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1L4d|AvODFvMUCwJO69VQ>? M1rOXFQ5KGh? MVTMc4chT0l3ME2tO{41PyCP Mne4NlI{OzZ{NE[=
MKN1 Mmr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTDNE4xOS1zMECg{txO NIXFcVE1QCCq MkW4UI9oKEeLNUC9MVgvPDFiTR?= NYXmbmxCOjJ|M{[yOFY>
MKN7 M3rwdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDNUVExNjBzLUGwNEDPxE1? NILHbXY1QCCq NF:2fnRNd2diR1m1NF0uPy54ODDN NFvpfWozOjN|NkK0Oi=>
MKN28 NUm5ZXJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrZW3V7OC5yMT2xNFAh|ryP M3HVbVQ5KGh? NHPIOWxNd2diR1m1NF0uPy5yNzDN NWHpXmNIOjJ|M{[yOFY>
MKN45 NUTXSpc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH5fGVFOC5yMT2xNFAh|ryP NX;2TIVwPDhiaB?= M3XvV2xw\yCJSUWwQU05NjN2IF2= MW[yNlM{PjJ2Nh?=
MKN74 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVywMlAyNTFyMDFOwG0> MYK0PEBp MV\Mc4chT0l3ME2tO{41OiCP M1H5dFIzOzN4MkS2
DU145 M325dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Kz[lAvODFvMUCwJO69VQ>? M4LEWFQ5KGh? MULMc4chT0l3ME2tPE4yPiCP M{LudFIzOzN4MkS2
PC3 M4roR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\we|AvODFvMUCwJO69VQ>? NYjseJREPDhiaB?= M{nZSmxw\yCJSUWwQU05NjZ4IF2= NYXvcWRjOjJ|M{[yOFY>
Trypanosoma brucei brucei NHLDTZZHfW6ldHnvckBCe3OjeR?= MYqyNFAhdk1? Ml7xNVIhcA>? NFHuRpdFVVOR NVrLboFiTGWlcnXhd4UhcW5icHjvd5Bpd3SrZInsJIlvd3OrdH;sJJBpd3OyaHH0[UBt\X[nbB?= NWH1b5pXOjR6MEW5OFY>
Trypanosoma brucei brucei NI\0W45HfW6ldHnvckBCe3OjeR?= MnXENVghcA>? NE\QWWZFVVOR NV23UFNGUW6qaXLpeIlwdiCxZjDy[YNmeHSxcj3t[YRq[XSnZDDlcoRw[3m2b4Ppd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjD0doFve2[ncoLpckB2eHSja3W= NGTGbHgzPDhyNUm0Oi=>
Trypanosoma brucei brucei MWTGeY5kfGmxbjDBd5NigQ>? MUGyNFAhdk1? M4C4[lEzKGh? NHjV[VVFVVOR Mmi3SYZn\WO2IH;uJJNxcGmwZ3;tfYxmcW5ibHX2[Yw> NHm5[oEzPDhyNUm0Oi=>
Trypanosoma brucei brucei NHPjW3NHfW6ldHnvckBCe3OjeR?= MnjyNlAxKG6P M3;GdFEzKGh? NHLKS2JFVVOR M3LJRWVn\mWldDDvckBxcG:|cHjheIllgWylaH;sbY5mKGyndnXs MVeyOFgxPTl2Nh?=
UM-UC-3 M2nyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjtclNKSzVyPUOxOUBxVQ>? M{jKT3NCVkeHUh?=
SBC-1 NWW4PIRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTd2MjDwUS=> MWXTRW5ITVJ?
MKN1 MmDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHsOnJKSzVyPUKuPEBvVQ>? M{XWTHNCVkeHUh?=
NCI-H720 NXvkTVVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\FN5dKSzVyPUOuOVchdk1? MkTKV2FPT0WU
BFTC-909 NXzPPFdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fZOWlEPTB;Mz63NUBvVQ>? MmfVV2FPT0WU
BPH-1 NHH3WIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTRwN{[gcm0> MkDPV2FPT0WU
PC-3 NYHuRVdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTVwMEmgcm0> M2DuV3NCVkeHUh?=
AN3-CA M32wNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rzPWlEPTB;NT61OkBvVQ>? Mn7YV2FPT0WU
HN MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;OTWM2OD13Lkm2JI5O NI\jXGpUSU6JRWK=
HCC2218 NFW2dHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LLeWlEPTB;Nj62NUBvVQ>? NHrLXYZUSU6JRWK=
KP-4 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLPbmJHUUN3ME23JI5O MU\TRW5ITVJ?
LU-139 MlzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPicXNKSzVyPUeuO|chdk1? NX3xdFRqW0GQR1XS
ETK-1 NXruXpZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml6xTWM2OD15Lki4JI5O MUjTRW5ITVJ?
Ramos-2G6-4C10 NFHybY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r4VmlEPTB;OD60PUBvVQ>? MoO4V2FPT0WU
MHH-PREB-1 M4LZPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV36VpdRUUN3ME25MlEzKG6P MVjTRW5ITVJ?
DU-4475 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnDTWM2OD17LkS0JI5O M1XTW3NCVkeHUh?=
NCI-H1666 NYDYU|dFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVWyS2NiUUN3ME25MlcyKG6P MUHTRW5ITVJ?
CAMA-1 NEL2THdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDGTWM2OD17Lkigcm0> MVTTRW5ITVJ?
TYK-nu MmnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkWwTWM2OD17Lkm0JI5O NELNPJZUSU6JRWK=
MFE-280 NUL4Sm5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDlO5ZKSzVyPUmuPVkhdk1? M364ZnNCVkeHUh?=
A549 NV7KW5d{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PIV2lEPTB;MUCuNVQhdk1? M4DJenNCVkeHUh?=
769-P NF21eXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTFyLkS0JI5O NGXGc|hUSU6JRWK=
L-363 M{nYPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTFyLk[5JI5O NYfmUHV{W0GQR1XS
ES8 M2rUU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfmTWM2OD1zMD65JI5O Mon3V2FPT0WU
PA-1 NHvtdHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX3TWM2OD1zMT64NkBvVQ>? NF\Ue2hUSU6JRWK=
Mewo MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTkNIFKSzVyPUGxMlk6KG6P NHi5UXdUSU6JRWK=
HSC-3 NH;kfIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17OUWlEPTB;MUKuNlEhdk1? MVPTRW5ITVJ?
H4 MlP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jvTmlEPTB;MUKuOlchdk1? NF;UO4RUSU6JRWK=
BB65-RCC MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HXOGlEPTB;MUKuO|Ihdk1? M1rCT3NCVkeHUh?=
NCI-H1793 NILJc4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXZTWM2OD1zMj64NkBvVQ>? NHGwc|NUSU6JRWK=
KARPAS-45 NEDRSFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlexTWM2OD1zMz61NUBvVQ>? Mm\WV2FPT0WU
GCT MnnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17YVmlEPTB;MUOuOlghdk1? MUnTRW5ITVJ?
EoL-1 M2jWTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M176T2lEPTB;MUOuPVMhdk1? NYe0e4tOW0GQR1XS
LB2241-RCC NUC0XFRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jlbGlEPTB;MUSuNFEhdk1? MnPJV2FPT0WU
ES5 M3HzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Oze2lEPTB;MUSuO|Qhdk1? M1LhenNCVkeHUh?=
LOXIMVI NFTITodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVP6XINmUUN3ME2xOE46QSCwTR?= MXjTRW5ITVJ?
COR-L105 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3mTWM2OD1zNT6wOEBvVQ>? MkPuV2FPT0WU
P12-ICHIKAWA MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NESyUIRKSzVyPUG1MlEhdk1? M1PkcXNCVkeHUh?=
CHL-1 MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fZSGlEPTB;MUWuOFUhdk1? M1PQUnNCVkeHUh?=
VMRC-RCZ NHfib4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTF3Lk[zJI5O NF3jenZUSU6JRWK=
HH M{Sz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXVTWM2OD1zNT63JI5O M37sZXNCVkeHUh?=
NUGC-3 NF3Ld4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O0bGlEPTB;MU[uN|Qhdk1? MmHjV2FPT0WU
EGI-1 M37TeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3hTWM2OD1zNj60N{BvVQ>? MX7TRW5ITVJ?
OS-RC-2 M1r5OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPFbVBTUUN3ME2xOk41PyCwTR?= MmrhV2FPT0WU
MOLT-16 NFrkbVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknGTWM2OD1zNz6xOUBvVQ>? NFPC[YhUSU6JRWK=
NCI-H209 NEjScIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGyVpMxUUN3ME2xO{4zQSCwTR?= NWKyUJFjW0GQR1XS
697 NGe3dYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfBR|RuUUN3ME2xO{41OyCwTR?= NH\mbZNUSU6JRWK=
D-56MG MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF5Lk[5JI5O NEfWN|VUSU6JRWK=
VA-ES-BJ M{e0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGK5UIZKSzVyPUG3Mlg{KG6P M{jSO3NCVkeHUh?=
EW-16 NWfGUm1QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfqdHFvUUN3ME2xPE4xPCCwTR?= MmnCV2FPT0WU
HGC-27 NWfwO|BqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfXTWM2OD1zOD6wOkBvVQ>? MWDTRW5ITVJ?
ES7 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1L0NmlEPTB;MUiuNFkhdk1? MYDTRW5ITVJ?
HuH-7 NXnCUVE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DzcWlEPTB;MUiuOEBvVQ>? MV;TRW5ITVJ?
BCPAP M3fGd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jTWmlEPTB;MUiuOlUhdk1? MXXTRW5ITVJ?
SW1710 NFT3UlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTF6LkeyJI5O MWLTRW5ITVJ?
IST-MEL1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn5TWM2OD1zOD63O{BvVQ>? NILY[GFUSU6JRWK=
SF295 M{PRNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LKfGlEPTB;MUiuPVMhdk1? NH7W[VhUSU6JRWK=
RPMI-7951 NEmwT2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTF7LkK4JI5O MX\TRW5ITVJ?
SF126 NUPOW|JrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfFcXdKSzVyPUG5MlQyKG6P M2nncnNCVkeHUh?=
GAMG NICxS3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLEfW5DUUN3ME2xPU41QCCwTR?= NH3CdIVUSU6JRWK=
KNS-81-FD NHXweYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF7LkW0JI5O NHvocmdUSU6JRWK=
RT-112 M4nhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTF7Lk[2JI5O NYfBTJRUW0GQR1XS
DEL MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M12zWmlEPTB;MkCuOFkhdk1? MnTIV2FPT0WU
CGTH-W-1 NV23d2x2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTJyLk[zJI5O NHzYcFdUSU6JRWK=
HOS Mkf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;kcXA5UUN3ME2yNU4xPiCwTR?= Mme1V2FPT0WU
ES4 NWeyZWtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{C2WmlEPTB;MkGuNFghdk1? NVzUXXpnW0GQR1XS
RXF393 MlPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f1bmlEPTB;MkGuOFUhdk1? MWfTRW5ITVJ?
NCI-H2030 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\ERlU1UUN3ME2yNU42OiCwTR?= M33xPHNCVkeHUh?=
YH-13 M1qxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnr3TWM2OD1{MT64PEBvVQ>? MlrQV2FPT0WU
HT-1080 M{fBNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrV[4lwUUN3ME2yNU46OyCwTR?= Mlv4V2FPT0WU
NCI-SNU-1 M1rSfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDrUmwxUUN3ME2yNU46PSCwTR?= NXLhRnNFW0GQR1XS
G-402 NWTvPVdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m2b2lEPTB;MkKuNVYhdk1? NX\hUVJ{W0GQR1XS
786-0 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPVb5hKSzVyPUKyMlI6KG6P M3nvfXNCVkeHUh?=
ME-180 M1nY[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PjRmlEPTB;MkKuOFMhdk1? MYDTRW5ITVJ?
NB69 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF61[5ZKSzVyPUKyMlU{KG6P M3;CXnNCVkeHUh?=
J-RT3-T3-5 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Pje2lEPTB;MkKuPVYhdk1? NGf4c3RUSU6JRWK=
TGBC1TKB NEPxSYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTJ|LkC1JI5O M1fSeHNCVkeHUh?=
SW780 M3S1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XNbmlEPTB;MkOuNVMhdk1? M1rPSXNCVkeHUh?=
MG-63 MoqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHYSHRKSzVyPUKzMlQ2KG6P M2THfnNCVkeHUh?=
BV-173 NFzobXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHuTWM2OD1{Mz64O{BvVQ>? NHfhZpZUSU6JRWK=
CAL-51 MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPKeoFMUUN3ME2yN{45QSCwTR?= MUHTRW5ITVJ?
A375 M1nBbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP0TWM2OD1{Mz65N{BvVQ>? NWjjb5Q6W0GQR1XS
MEL-HO Mm\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJ2LkC0JI5O NYHjO25HW0GQR1XS
EFO-27 M4CzeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJ2LkOzJI5O MYjTRW5ITVJ?
Hs-578-T MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPyTWM2OD1{ND61PEBvVQ>? M2PXNnNCVkeHUh?=
NBsusSR MoT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq0e5ZKSzVyPUK0MlYhdk1? MlrMV2FPT0WU
CTB-1 MnPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PYV2lEPTB;MkSuOlchdk1? M2HUenNCVkeHUh?=
FTC-133 NEDtZ4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1u3VGlEPTB;MkWuNUBvVQ>? MUfTRW5ITVJ?
MOLT-4 NEjLcZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfqV3JKSzVyPUK1MlEzKG6P NEO4TYxUSU6JRWK=
HO-1-N-1 M3PMS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnQTWM2OD1{NT6xOUBvVQ>? NGO0Um1USU6JRWK=
ES3 NIP6N3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIe0fXdKSzVyPUK1MlIzKG6P M4\LSHNCVkeHUh?=
TI-73 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL0TWM2OD1{NT6yPEBvVQ>? MXnTRW5ITVJ?
MPP-89 M2\mUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1v0OGlEPTB;MkWuN|Ihdk1? NHWzVHpUSU6JRWK=
KYSE-150 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjoeVhKSzVyPUK1Mlg6KG6P MX;TRW5ITVJ?
LXF-289 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJ4LkC0JI5O NV20[ZRyW0GQR1XS
SK-LU-1 NHzzcpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;od4hjUUN3ME2yOk4yPyCwTR?= NFWwZXdUSU6JRWK=
HOP-92 NGjmOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\XTWM2OD1{Nj60PEBvVQ>? NVrJUHZwW0GQR1XS
HuO9 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\RZ2xqUUN3ME2yOk44PiCwTR?= MXPTRW5ITVJ?
SW962 NWHBR2Z6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7TdGFKSzVyPUK2Mlc3KG6P NXHFe3NoW0GQR1XS
RS4-11 MoDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHZfmVKSzVyPUK2MlkyKG6P M{\hUnNCVkeHUh?=
NCI-H292 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\VNGpKSzVyPUK3JI5O MXzTRW5ITVJ?
DB NI\yZodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTJ5LkO2JI5O NH7GSFJUSU6JRWK=
SW1088 NXXhSHpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnm3TWM2OD1{OD6yPUBvVQ>? NULmS3F6W0GQR1XS
A204 M1z4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHraSVJKSzVyPUK4MlQ4KG6P NFTabVVUSU6JRWK=
A3-KAW NV6wNItjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFe4[3ZKSzVyPUK4MlY1KG6P NXzqdYJGW0GQR1XS
MV-4-11 MkDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jibmlEPTB;MkiuO{BvVQ>? NV7TfnpUW0GQR1XS
ES1 M37CcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\LPVZnUUN3ME2yPE45PCCwTR?= MkXvV2FPT0WU
ONS-76 NYfFPFlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW2SGVKSzVyPUK5MlA2KG6P NGD1XZNUSU6JRWK=
D-263MG NVrL[XVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTJ7LkO1JI5O MYrTRW5ITVJ?
U-2-OS Mm\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2WwbmlEPTB;MkmuOUBvVQ>? NGC1VnZUSU6JRWK=
T98G NIrxUZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXhd|lKSzVyPUK5Mlg5KG6P MmGyV2FPT0WU
GI-ME-N NFLGWGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn75TWM2OD1{OT65NUBvVQ>? MWjTRW5ITVJ?
BHT-101 NXHkNVhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTNyLkC1JI5O NX64WFk{W0GQR1XS
NOS-1 NF\hfHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXz5UYZTUUN3ME2zNE4yOiCwTR?= MWjTRW5ITVJ?
AsPC-1 M3XiTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTYTWM2OD1|MD6yJI5O NV;XeZJZW0GQR1XS
QIMR-WIL NXjJPZpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nsXGlEPTB;M{CuOkBvVQ>? MWHTRW5ITVJ?
JVM-3 M17LO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rFZmlEPTB;M{CuPFMhdk1? MYXTRW5ITVJ?
KU-19-19 NXzIWFJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGT4S3BKSzVyPUOxMlE{KG6P NFzXNYVUSU6JRWK=
OVCAR-8 NGLVcGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrQTWM2OD1|MT6yOkBvVQ>? NVnWR3dTW0GQR1XS
BEN M{XZWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr3TWM2OD1|MT62N{BvVQ>? MWPTRW5ITVJ?
BE-13 Mkm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\OXXBWUUN3ME2zNU45OiCwTR?= MkfIV2FPT0WU
EW-18 MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D0SmlEPTB;M{GuPFYhdk1? NYfLb41ZW0GQR1XS
ECC10 M2qwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnWxTWM2OD1|MT65OUBvVQ>? MkW0V2FPT0WU
CTV-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[wTWM2OD1|Mj64NkBvVQ>? M1fHV3NCVkeHUh?=
COLO-800 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLuSplKSzVyPUOyMlkzKG6P MmrIV2FPT0WU
A2058 M3zrOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrHTWM2OD1|Mz6yOUBvVQ>? M4HTVHNCVkeHUh?=
VM-CUB-1 M4L3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTN|LkSzJI5O NXr3UGlwW0GQR1XS
Ca9-22 M{LsVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jOTGlEPTB;M{OuOVUhdk1? Mly3V2FPT0WU
COLO-684 NGH1dmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXBTWM2OD1|Mz61PEBvVQ>? NWP0c45ZW0GQR1XS
RPMI-8226 MonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTN|LkiyJI5O MXzTRW5ITVJ?
SK-NEP-1 MnH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTN2LkG1JI5O MULTRW5ITVJ?
Becker M2m2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrN[G5jUUN3ME2zOE4zOSCwTR?= MnzoV2FPT0WU
NCI-H28 NVzvZVlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTN2LkS0JI5O MlTSV2FPT0WU
CAL-120 NVL6b5lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXlW2JKSzVyPUO0MlczKG6P NV;TTYRuW0GQR1XS
MDA-MB-157 NHnkT4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q4fWlEPTB;M{WuOFEhdk1? M363[3NCVkeHUh?=
OVCAR-5 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PYU2lEPTB;M{WuOFchdk1? NVTidFdWW0GQR1XS
LAMA-84 NYS2fm5TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LKO2lEPTB;M{WuPFchdk1? M2DlfHNCVkeHUh?=
CAKI-1 NIW5e|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWqxeY95UUN3ME2zOk41OyCwTR?= M4fUS3NCVkeHUh?=
Daoy NEXv[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPtTWM2OD1|Nj63JI5O MXrTRW5ITVJ?
CAL-62 Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj2TWM2OD1|Nj64OkBvVQ>? Ml3iV2FPT0WU
8-MG-BA MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG5TWM2OD1|Nz6yOUBvVQ>? MYrTRW5ITVJ?
8505C MkLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXpcWhKSzVyPUO3MlUyKG6P NHPiWmJUSU6JRWK=
LNCaP-Clone-FGC M372e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO5V|NKSzVyPUO3MlU6KG6P NXPWeYF2W0GQR1XS
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MN-60 M1:0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTN5Lkm2JI5O NXm1bpZ{W0GQR1XS
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U251 NEjXZVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTN6LkSzJI5O MnLyV2FPT0WU
SJSA-1 NXXibWVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PGT2lEPTB;M{iuOVQhdk1? Mnz5V2FPT0WU
CAL-12T MoXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTYTWM2OD1|OD62JI5O NFrtdVZUSU6JRWK=
HCC1419 NI\LOVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO0RlVKSzVyPUO4MlcyKG6P MnTnV2FPT0WU
CO-314 M1zKWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTN6Lke0JI5O MkHvV2FPT0WU
LB1047-RCC M1zZ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PMWmlEPTB;M{iuPFEhdk1? M4DRW3NCVkeHUh?=
A101D MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTN6Lkm3JI5O NELsNXJUSU6JRWK=
MDA-MB-175-VII NG\HVoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rT[WlEPTB;M{muOVEhdk1? NEi5VnNUSU6JRWK=
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G-401 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjqTWM2OD12MD64NkBvVQ>? NFrD[XRUSU6JRWK=
HT MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULrNIFoUUN3ME20NU4xOiCwTR?= M4Pk[nNCVkeHUh?=
8305C NFTwe|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfE[Y5wUUN3ME20NU45PyCwTR?= M3r4S3NCVkeHUh?=
BHY MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTR{LkeyJI5O NVzpWGpTW0GQR1XS
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T-24 NUnLVVFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DFRmlEPTB;NEOuPFMhdk1? M{DPPXNCVkeHUh?=
EPLC-272H MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTR2LkO5JI5O MXPTRW5ITVJ?
PSN1 NWjRNow5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjQNZhTUUN3ME20OE41KG6P MYjTRW5ITVJ?
NCI-H2452 M{XFUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3mx[GlEPTB;NESuOVghdk1? MmHWV2FPT0WU
KS-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\nemhbUUN3ME20OE43PiCwTR?= MYnTRW5ITVJ?
HD-MY-Z M3nIU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn32TWM2OD12ND65NkBvVQ>? M3PBXXNCVkeHUh?=
KNS-62 NX73dFh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXX5W2lqUUN3ME20OU4{QCCwTR?= M3LaO3NCVkeHUh?=
NOMO-1 Mm\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTR3Lki3JI5O NGXNWY1USU6JRWK=
SK-HEP-1 M{T1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzjUYVKSzVyPUS2MlA1KG6P NFz3SnJUSU6JRWK=
IGR-1 M1LG[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTR4LkGzJI5O NUfhbIdHW0GQR1XS
KYSE-180 NIDEXnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTR4LkG3JI5O M4TEOnNCVkeHUh?=
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NCI-H1355 M{DabWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvFSYZiUUN3ME20Ok4{PCCwTR?= MXPTRW5ITVJ?
DOHH-2 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETJboJKSzVyPUS2MlM4KG6P MVnTRW5ITVJ?
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PC-14 NEWxW25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\ZTWM2OD12Nj61O{BvVQ>? MnfkV2FPT0WU
TE-5 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTR4Lki0JI5O MoPKV2FPT0WU
LB996-RCC NV3OcYw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPmTm5KSzVyPUS3MlE6KG6P MYfTRW5ITVJ?
NCI-H1623 NXPVV4JLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnVPGRKSzVyPUS3Mlc3KG6P NWqxN2lsW0GQR1XS
NCI-H1155 M2i5Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTR6LkOyJI5O MnPPV2FPT0WU
LoVo M3z6cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVW3eW1SUUN3ME20PE41KG6P NGPlSWpUSU6JRWK=
MCF7 NF:wTZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13s[mlEPTB;NEiuOVghdk1? NHy2SHBUSU6JRWK=
AGS Ml;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfYeXFLUUN3ME20PE44PyCwTR?= NWXrSVRjW0GQR1XS
PFSK-1 MlK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfhdXFKSzVyPUS5MlA3KG6P NVixT2RPW0GQR1XS
22RV1 NVzyb|FDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Xmb2lEPTB;NEmuNFkhdk1? NITNbnBUSU6JRWK=
COR-L23 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{niUGlEPTB;NEmuNVYhdk1? M1TkZ3NCVkeHUh?=
D-283MED NHvVNJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ixNmlEPTB;NEmuOlEhdk1? M{SwcXNCVkeHUh?=
SW982 M1uxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTR7LkmxJI5O MVHTRW5ITVJ?
SW620 MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTVyLkO2JI5O Mn3jV2FPT0WU
KYSE-140 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlL2TWM2OD13MD61OUBvVQ>? M3nPTXNCVkeHUh?=
GCIY MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfUTWM2OD13MD62O{BvVQ>? NI\xUXJUSU6JRWK=
MHH-ESS-1 MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDxbWlKSzVyPUWxMlk2KG6P NV\hN4lEW0GQR1XS
D-423MG NIW4TW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2n5eGlEPTB;NUKuNFghdk1? NU\F[VJuW0GQR1XS
SF539 Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nsWGlEPTB;NUKuN|Uhdk1? NVfsZ4dFW0GQR1XS
RPMI-2650 MnzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzzUY5KSzVyPUWyMlY6KG6P MnLPV2FPT0WU
GR-ST MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfIS3c2UUN3ME21Nk45PyCwTR?= MUPTRW5ITVJ?
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SK-MES-1 NVXhS|A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLzeoRKSzVyPUWzMlI3KG6P NFnWZo1USU6JRWK=
HLE NX;TUlE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjDWWNKSzVyPUWzMlQ4KG6P NXPke3FWW0GQR1XS
RVH-421 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\hdWVLUUN3ME21N{43PyCwTR?= MY\TRW5ITVJ?
C32 MmT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTV|LkizJI5O MYPTRW5ITVJ?
GB-1 NGHUd5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD1TWM2OD13ND6yJI5O NYnnVJc1W0GQR1XS
SNB75 MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvl[WVKSzVyPUW0MlI3KG6P MXLTRW5ITVJ?
EM-2 NF74dJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWj0e2xKUUN3ME21OE41KG6P NXjrbHZ{W0GQR1XS
RH-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTV2Lkegcm0> NY\sT|ZCW0GQR1XS
NKM-1 MmrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1npSGlEPTB;NUSuPFEhdk1? M2XZZnNCVkeHUh?=
NCI-H2405 NI[5ZlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;OPVFKSzVyPUW0Mlg5KG6P M1HiWnNCVkeHUh?=
KYSE-450 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTV3LkG2JI5O NGXhN3ZUSU6JRWK=
A704 Mk\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXSd3RKSzVyPUW1MlU6KG6P NXP6dYtUW0GQR1XS
HAL-01 NFP5OXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTV3LkizJI5O M{DKdXNCVkeHUh?=
TE-11 M17hSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3SNo5KSzVyPUW1Mlk6KG6P NXTmd2xVW0GQR1XS
DOK NV;wOWZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLWPWJZUUN3ME21Ok4xOiCwTR?= NX[0OolEW0GQR1XS
KY821 NXPMS497T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjMTWM2OD13Nj6yJI5O MWPTRW5ITVJ?
KGN NXrOd2U1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PjXGlEPTB;NU[uN|Ihdk1? NIHxN3VUSU6JRWK=
MC116 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\uNXdyUUN3ME21O{45KG6P NX3mTYl4W0GQR1XS
PANC-08-13 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvPd4RKSzVyPUW4MlAyKG6P M1HRd3NCVkeHUh?=
KE-37 M2\abmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTV6Lke3JI5O M3Xi[XNCVkeHUh?=
KYSE-410 MonLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvoXlg5UUN3ME21PU41PyCwTR?= NIrXZpJUSU6JRWK=
RO82-W-1 Mn7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f3b2lEPTB;NUmuPUBvVQ>? NYTzeGpTW0GQR1XS
M14 NULJeVVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\zTWM2OD14MD6wOEBvVQ>? MnHlV2FPT0WU
GI-1 NGfFU49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfPSZJKSzVyPU[wMlMhdk1? NXr6dIxMW0GQR1XS
ML-2 MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXK[opKSzVyPU[wMlYzKG6P MXjTRW5ITVJ?
BFTC-905 MmS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\afWlEPTB;NkCuOlUhdk1? MnW0V2FPT0WU
DMS-273 M3voemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HnWGlEPTB;NkCuPFchdk1? NVTwdZZsW0GQR1XS
MDA-MB-361 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTZzIH7N NU\0SIR5W0GQR1XS
MSTO-211H M1y4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTZ|LkWxJI5O M{\Fe3NCVkeHUh?=
MEG-01 M{HBWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXRN4pKSzVyPU[zMlUzKG6P NGLLUVlUSU6JRWK=
M059J MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTZ|LkW4JI5O M2jQUXNCVkeHUh?=
LN-405 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTZ|Lki1JI5O MWfTRW5ITVJ?
NCI-H1581 M2Sw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTZ2LkCzJI5O MmPFV2FPT0WU
TCCSUP NECwXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmroTWM2OD14ND61N{BvVQ>? NIrRSpdUSU6JRWK=
SW872 M2XCWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPo[4cyUUN3ME22OE42PyCwTR?= NWDpVHo{W0GQR1XS
KYSE-510 M3jhXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTZ3Lke1JI5O Ml7SV2FPT0WU
NCI-H1792 NGr3RlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLXTWM2OD14Nj6xOUBvVQ>? MojPV2FPT0WU
SW13 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fvN2lEPTB;Nk[uOUBvVQ>? NU\oSXhwW0GQR1XS
TE-8 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjzTWM2OD14Nj61NkBvVQ>? NVzzSVduW0GQR1XS
SCH MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTZ5LkGgcm0> NGKxZYZUSU6JRWK=
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EFM-19 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDJcG5KSzVyPU[3MlUhdk1? NH;hS4JUSU6JRWK=
HEC-1 NGDFTWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHm3O5BKSzVyPU[3MlUzKG6P MV7TRW5ITVJ?
T47D M2XTVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXlfm9KUUN3ME22O{45PyCwTR?= MmnnV2FPT0WU
SNU-423 NVv1bGhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFWxepBKSzVyPU[3Mlk5KG6P NYnWbW91W0GQR1XS
WM-115 NXP2fXMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPMcGRkUUN3ME22PE4yPCCwTR?= M1K1bXNCVkeHUh?=
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KU812 NVHUcolNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LUOmlEPTB;NkiuOlkhdk1? NELab3lUSU6JRWK=
AM-38 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIW5VWxKSzVyPU[5MlMyKG6P M3HDfHNCVkeHUh?=
KOSC-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFy0UG9KSzVyPU[5Mlk4KG6P MWPTRW5ITVJ?
MC-IXC NYjuUopwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LubGlEPTB;N{CuNFghdk1? NUXsVplZW0GQR1XS
SCC-4 MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnztTWM2OD15MT6zPEBvVQ>? MVjTRW5ITVJ?
Calu-3 Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW2c2dKSzVyPUexMlk5KG6P NVPBe4JxW0GQR1XS
RPMI-8866 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHVS5BxUUN3ME23Nk45OiCwTR?= M1TObHNCVkeHUh?=
OVCAR-4 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nLVmlEPTB;N{OuN|Yhdk1? MVrTRW5ITVJ?
OAW-42 NUfLWG17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTd|LkO5JI5O Mn;wV2FPT0WU
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CHP-212 NEPRPY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXBOHBKSzVyPUe0Mlk2KG6P NHjkcIJUSU6JRWK=
C2BBe1 NEDRU2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nhXWlEPTB;N{WuNFMhdk1? NGjXSFVUSU6JRWK=
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SH-4 M1fR[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nB[2lEPTB;N{WuNlEhdk1? M2TTWHNCVkeHUh?=
SNU-449 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\FRVRKSzVyPUe1Mlc6KG6P MmPPV2FPT0WU
RD NGjMT5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTd3Lki2JI5O M{HVcXNCVkeHUh?=
PANC-03-27 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYf6TWZmUUN3ME23Ok4zPSCwTR?= NVnkbI1KW0GQR1XS
S-117 M1fYUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHGbYgzUUN3ME23Ok4zPyCwTR?= NGXUdI1USU6JRWK=
SK-MEL-2 M{m3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTd4Lke1JI5O Ml7VV2FPT0WU
LK-2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXGwdWprUUN3ME23O{4xPSCwTR?= NEjteY9USU6JRWK=
CP50-MEL-B M170XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTd5LkSgcm0> M{OzOXNCVkeHUh?=
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LU-65 MkWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXX2XGlNUUN3ME2xMlYzOjR7IN88US=> MnrYV2FPT0WU
NCI-H1304 M{XiRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULwb|dLUUN3ME2xMlY2PDl6IN88US=> NHnqbGZUSU6JRWK=
KARPAS-299 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\2NGlEPTB;MT63PVQ4QSEQvF2= MUnTRW5ITVJ?
NCI-H358 MojIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVS4bG84UUN3ME2xMlk2PTB|IN88US=> MnrhV2FPT0WU
OAW-28 NV;5R3NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn24TWM2OD1{LkC2PVE6KM7:TR?= MVzTRW5ITVJ?
C8166 NYfTUYprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjKWVhuUUN3ME2yMlY{Ozl{IN88US=> MkDVV2FPT0WU
COLO-678 NYjkdlcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\hem5KSzVyPUKuPFM4PjhizszN NVvaSpNJW0GQR1XS
SK-N-DZ MmK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVe5Um9KUUN3ME2yMlg3OzhzIN88US=> MX7TRW5ITVJ?
NCI-H82 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJwOUCzOlkh|ryP NUTQVJZ7W0GQR1XS
JVM-2 M3jhO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:3TWM2OD1|LkCzNVg5KM7:TR?= NFjyR2lUSU6JRWK=
SW1116 MkPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjacFgzUUN3ME2zMlA2PDFzIN88US=> NV;tTlFQW0GQR1XS
MDA-MB-453 NYK4NXY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2S2VGlEPTB;Mz6xNFQ{QSEQvF2= NGTucpVUSU6JRWK=
Calu-6 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnkTWM2OD1|LkG5PVch|ryP MWHTRW5ITVJ?
SHP-77 M4rzeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO5TotKSzVyPUOuOVI5KM7:TR?= Ml6xV2FPT0WU
Capan-2 M1WzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnsW|doUUN3ME20MlMzPThzIN88US=> NELHO3lUSU6JRWK=
SW948 MlfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVq0V|VTUUN3ME20Mlc1Pzd7IN88US=> NV3HRpQ1W0GQR1XS
HDLM-2 NGHNOYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzTTWM2OD13LkC3O|I2KM7:TR?= MVnTRW5ITVJ?
LAN-6 MkPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDEO4tTUUN3ME22MlIyPDl3IN88US=> MmTWV2FPT0WU
LU-135 NIKxW3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXiUnRGUUN3ME22MlQ{ODd5IN88US=> NGrWdphUSU6JRWK=
T84 NYXDU2lHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLnTJhKSzVyPU[uPVg3PCEQvF2= MnnpV2FPT0WU
CAPAN-1 NXznWohkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4eyU2lEPTB;Nz62NlI{OyEQvF2= MkW3V2FPT0WU
SW1417 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTdwOUG3N|Eh|ryP NX6wW4hEW0GQR1XS
BALL-1 NFrxSlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrkTpNKSzVyPUiuOVA1ODlizszN MnfHV2FPT0WU
HT-29 NHXxfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkm1TWM2OD17LkC3OVk6KM7:TR?= NHu1RWFUSU6JRWK=
C3A NVL6O4pIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vITWlEPTB;OT64PFM6PCEQvF2= MonrV2FPT0WU
NCI-H1993 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjzdHgyUUN3ME2xNE42ODhzIN88US=> M2\oZ3NCVkeHUh?=
SK-MEL-1 NGnudWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vjPWlEPTB;MUGuOlI5QSEQvF2= M4LSSXNCVkeHUh?=
DU-145 NFm1cJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnNO|NKSzVyPUG0MlUxPTJizszN M17vVXNCVkeHUh?=
KP-N-YN MnjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofuTWM2OD1zND61NVA{KM7:TR?= M{DVfXNCVkeHUh?=
CCRF-CEM NYDW[4l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1z6WGlEPTB;MUSuO|gxQSEQvF2= M3rRUXNCVkeHUh?=
ZR-75-30 MlX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPWZZlwUUN3ME2xOk4{OzB|IN88US=> NYH5NVJbW0GQR1XS
A673 Mn6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1za[GlEPTB;MkCuOVUxPyEQvF2= M1WxVXNCVkeHUh?=
K-562 M{PWW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfyTFBKSzVyPUK4MlQyQDNizszN M3;DUHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

体内研究 BEZ235诱导肿瘤(69%)消退,而对体重增加没有统计学上显著的作用。总之,这些初步的体内功效研究结果表明,BEZ235单一口服给药时能够阻断疾病的发展,与其他抗癌药结合使用时能够增强疗效。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[2]

+ 展开

体外蛋白激酶,PI3K,和mTOR实验:

PI3Kα, β, δ蛋白都由与p110全长蛋白相接的p85 N端的iSH2域组成,只是PI3Kα没有最后的20个氨基酸。PI3Kγ由p110全长蛋白去掉前144个氨基酸产生而来。所有PI3K蛋白在羧基末端加组氨酸标签便于纯化,然后克隆到pBlue-Bac4.5 (用于α, β,和δ亚型) 或者pVL1393 (用于γ 亚型) 质粒中。转染BaculoGold WT基因组DNA的不同的载体按说明书推荐的方法生产各自重组体杆状病毒及重组蛋白。使用激酶发光检测试剂盒测定BEZ235 (NVP-BEZ235)作用于PI3K的活力。在384孔板上进行激酶实验。在每个孔中加入50 nl的测试项目(溶在90%DMSO中)和5ul的反应buffer,反应buffer包含10 μg/ml PI基质 (l-α-磷脂酰肌醇; 由Avanti Polar Lipids提供;预备在3%辛基葡萄糖苷中),然后加入PI3K 蛋白(p110α, p110β, p110δ,和p110γ分别为10, 25, 10,和150 nM)。加入预备在反应buffer中的5 ul 1 µM 的ATP反应开始,反应进行60分钟 (测p110α, p110β, p110δ)或者120分钟(测p110γ),随后加入10ul的荧光激酶buffer终止反应。数据用Synergy 2 阅读器阅读用于荧光测试。
细胞实验:

[1]

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  • Cell lines: HCT116, DLD-1, SW480
  • Concentrations: 0-1 μM
  • Incubation Time: 48小时
  • Method:

    HCT116 (PIK3CA突变型; 激酶域在H1047R), DLD-1 (PIK3CA突变型;螺旋域在E545K), SW480 (PIK3CA 野生型)人类CRC细胞系,同基因型的DLD-1 PIK3CA突变和野生型细胞培养在含10%FBS和1×青霉素/链霉素的培养基中。细胞按不同的初始密度加入(HCT116: 3000个细胞/每孔, DLD-1: 5500个细胞/每孔, SW480: 4500个细胞/每孔, DLD-1 PIK3CA突变型: 7000个细胞/每孔, DLD-1 PIK3CA野生型: 9000个细胞/每孔),用来计算不同的生长动力学。16个小时后,细胞加入浓度越来越高的BEZ235中进行温育,含有药物的培养基24小时更换一次。根据产品说明书,加入细胞16小时和药物处理48小时,使用单溶液细胞增殖检测试剂盒以比色法检测细胞活力。与没有用药物处理正在生长的细胞相比,药物处理的细胞的活力也逐渐趋于正常化。使用GraphPad Prism 5软件用4个参数的回归曲线计算IC50值。用于western blot 分析,细胞用0 nM 或者最高抑制剂量(500 nM) BEZ235处理 2, 6, 24, 或者48 小时。


    (Only for Reference)
动物实验:

[2]

+ 展开
  • Animal Models: 雌性Harlan无胸腺裸鼠
  • Formulation: NMP/聚乙二醇300(10/90,v/v)
  • Dosages: 45 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
NMP+polyethylene glycol 300 (10+90, v+v)
30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 469.55
化学式

C30H23N5O

CAS号 915019-65-7
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01717898 Terminated Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2
NCT00620594 Completed Breast Cancer|Advanced Solid Tumors|Cowden Syndrome Novartis Pharmaceuticals|Novartis December 21 2006 Phase 1
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01658436 Completed Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis November 2012 Phase 2
NCT01628913 Terminated Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis October 2012 Phase 2
NCT01690871 Withdrawn Malignant PEComa (Perivascular Epithelioid Cell Tumors) Novartis Pharmaceuticals|Novartis September 2012 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • 回答:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

相关PI3K产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID