Afatinib (BIBW2992)

目录号:S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992)不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。

规格 价格 库存 购买数量  
RMB 1964.25 现货
RMB 977.68 现货
RMB 1724.11 现货
RMB 4652.69 现货
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客户购买Selleck的此次产品后发表的文献37篇:

客户使用该产品的4个实验数据:

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Afatinib (BIBW2992)不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。
靶点
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外研究

BIBW2992不可逆地抑制EGFR/HER2,在体外作用于野生型EGFR ,L858R突变型EGFR, L858R/T790M 双突变型EGFR,及HER2时IC50分别为0.5, 0.4, 10, 14 nM。在体外实验中,BIBW2992不管作用于野生型EGFR/HER2还是突变型EGFR/HER2都显示出强大的活力,与gefitinib作用于L858R突变型EGFR的活力差不多,但是要比gefitinib 作用于L858R-T790M双突变型EGFR的活力大100倍。在体外,BIBW2992有效抑制所有实验类型细胞的EGFR/HER磷酸化作用。比如人类扁平上皮癌A431细胞系表达的野生型EGFR, 鼠类NIH-3T3细胞转染的野生型HER2 , 以及乳腺癌BT-474细胞系和胃癌NCI-N87细胞系表达的内源性HER2。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 M2nIO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMEC1O|Ih|ryP MkO3V2FPT0WU
KASUMI-1 NWnHeWMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHvcoNKSzVyPUCuNFA6OTFizszN MYLTRW5ITVJ?
HCC2218 M3Paemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMEC5PFch|ryP NYntZXFMW0GQR1XS
KARPAS-45 NIrTe4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2P4bmlEPTB;MD6wNVY4OSEQvF2= M2qzZnNCVkeHUh?=
HSC-4 MmrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXjTWM2OD1yLkCxO|Q5KM7:TR?= M4DTd3NCVkeHUh?=
CHL-1 Ml[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jxeWlEPTB;MD6wNVg{QSEQvF2= MkH6V2FPT0WU
KY821 M3jRN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LhT2lEPTB;MD6wNlA3KM7:TR?= MXLTRW5ITVJ?
NCI-N87 NUX1co9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{K2bGlEPTB;MD6wNlc4OyEQvF2= MkPOV2FPT0WU
DOK NH;WTpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXvRpZ4UUN3ME2wMlA{OTl2IN88US=> M3npfnNCVkeHUh?=
DSH1 M2r0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW4Z|NKSzVyPUCuNFM{OTRizszN MYnTRW5ITVJ?
MDA-MB-175-VII MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjZTWM2OD1yLkCzOFE3KM7:TR?= M4m2e3NCVkeHUh?=
NCI-H2170 M2fMRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVX0V|FiUUN3ME2wMlA{PzJ6IN88US=> MoTzV2FPT0WU
BT-474 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHyTWM2OD1yLkC0PVg3KM7:TR?= MUPTRW5ITVJ?
EFO-27 M1vTemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3hN4JtUUN3ME2wMlA2OTh{IN88US=> Mlf6V2FPT0WU
NCI-H720 NXnXV5JGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofsTWM2OD1yLkC1N|I2KM7:TR?= MV3TRW5ITVJ?
PC-14 M37T[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHF[mJLUUN3ME2wMlA2PjZ6IN88US=> MX7TRW5ITVJ?
EC-GI-10 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3NUop[UUN3ME2wMlA2QTF{IN88US=> NX20SldWW0GQR1XS
KYSE-450 M1LNW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMEW5O|gh|ryP NV3JXYJoW0GQR1XS
BPH-1 NWf6Rpg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\4bm5vUUN3ME2wMlA2QTh6IN88US=> NYTnU49kW0GQR1XS
NCI-H292 NVPzSItrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zYW2lEPTB;MD6wOlA6KM7:TR?= MnvVV2FPT0WU
H9 M4XpZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3mbWdKSzVyPUCuNFcyOzJizszN Mnv3V2FPT0WU
NCI-H526 NXjMUFVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXRWJdmUUN3ME2wMlA4QDJ|IN88US=> MYHTRW5ITVJ?
NCI-H1623 NGCwOVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTzTWM2OD1yLkC4NFI2KM7:TR?= NGG1VpVUSU6JRWK=
KYSE-140 M{fWUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTBfpdSUUN3ME2wMlA5OzNizszN NFn3WJdUSU6JRWK=
Ca9-22 NHHSbG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlThTWM2OD1yLkC4N|U{KM7:TR?= NVLvfI04W0GQR1XS
AU565 M3r6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7WTYdPUUN3ME2wMlA5PTB2IN88US=> NUS0OpJ7W0GQR1XS
ZR-75-30 NYj2T|RsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnz3TWM2OD1yLkC5OVQ2KM7:TR?= MkXmV2FPT0WU
NCI-H1770 MnLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXWwSmhKUUN3ME2wMlExOjhizszN M{HPT3NCVkeHUh?=
LB2241-RCC NF:0eGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NES3RmJKSzVyPUCuNVA5QDRizszN NVXLXpUzW0GQR1XS
CAL-39 M33lR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jHWWlEPTB;MD6xNVc6OiEQvF2= MYnTRW5ITVJ?
UACC-893 M4Lld2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX4N4VbUUN3ME2wMlEyQDh3IN88US=> MoPuV2FPT0WU
LU-65 M1XhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMUK2N|Mh|ryP NHPGUXZUSU6JRWK=
HN M3nqXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;3d5F5UUN3ME2wMlE{ODd5IN88US=> MnzRV2FPT0WU
TI-73 M4LSW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\kW2lEPTB;MD6xOFcyPSEQvF2= MlPVV2FPT0WU
KU812 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPGR|FKSzVyPUCuNVU1PTZizszN NV;jSYp7W0GQR1XS
SW13 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMU[yNVYh|ryP NIDhd|JUSU6JRWK=
BB30-HNC NHv6dJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMU[1O|Yh|ryP MYHTRW5ITVJ?
HSC-2 M3ziWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PXSGlEPTB;MD6xOlg{PyEQvF2= MlXjV2FPT0WU
BV-173 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHRZ2NKSzVyPUCuNVc2QTZizszN MVjTRW5ITVJ?
CAL-27 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMUe2N|Yh|ryP NGrUc3RUSU6JRWK=
SBC-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\MfYhVUUN3ME2wMlE5QTV7IN88US=> M4ezZ3NCVkeHUh?=
CAL-33 NGK5NHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;vTWM2OD1yLkKwNVg1KM7:TR?= MX3TRW5ITVJ?
NCI-H209 MlrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTVeoRKSzVyPUCuNlA1PiEQvF2= MWXTRW5ITVJ?
COR-L105 M3XUXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnlZ3plUUN3ME2wMlIyODh2IN88US=> NIHQdWFUSU6JRWK=
HSC-3 M1TSfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jHVWlEPTB;MD6yNVE6QCEQvF2= MXPTRW5ITVJ?
NCI-H69 MnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nX[mlEPTB;MD6yNVQ2OSEQvF2= NIP3TVNUSU6JRWK=
MOLT-13 NHT3doRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMkO5O|Uh|ryP NVLoT2U5W0GQR1XS
ML-2 M3PFTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUe5UGxbUUN3ME2wMlI1QDB{IN88US=> Ml;EV2FPT0WU
IGROV-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljZTWM2OD1yLkK1PVUzKM7:TR?= Mki0V2FPT0WU
TK10 M{j0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMk[3N|gh|ryP M1nCbHNCVkeHUh?=
EoL-1-cell NWrLZ4ZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS2boxKSzVyPUCuNlY5QTJizszN M3jhcnNCVkeHUh?=
HO-1-N-1 NYD0c5J3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjxTWM2OD1yLkK3PFU{KM7:TR?= MXrTRW5ITVJ?
BHY M2XRTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMki2OVUh|ryP M1vyRXNCVkeHUh?=
LU-139 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfiUlNKSzVyPUCuN|A2OSEQvF2= MWfTRW5ITVJ?
23132-87 MnHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DBe2lEPTB;MD6zNVkzOyEQvF2= MnqwV2FPT0WU
ACHN NHTEdZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnO3TWM2OD1yLkOxPVk1KM7:TR?= MX;TRW5ITVJ?
DoTc2-4510 MkHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnzd2xpUUN3ME2wMlMzOjF7IN88US=> MXvTRW5ITVJ?
BB65-RCC M1qwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknuTWM2OD1yLkO0OVk{KM7:TR?= Moi3V2FPT0WU
HLE M4m0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nMfGlEPTB;MD6zOVA1PiEQvF2= M4nMN3NCVkeHUh?=
HCC1419 NGfqcZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3ScmhKSzVyPUCuN|Y1ODhizszN MVrTRW5ITVJ?
A388 M4jER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;kUlFKSzVyPUCuN|Y5PTdizszN MUPTRW5ITVJ?
NUGC-3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TJXGlEPTB;MD6zPFM4OyEQvF2= M4rRV3NCVkeHUh?=
KYSE-180 NGXpWm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HMOWlEPTB;MD6zPVA5QSEQvF2= NY\ETW9KW0GQR1XS
TE-6 MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLoUZR5UUN3ME2wMlQxOjR4IN88US=> MoTtV2FPT0WU
A498 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\S[YsxUUN3ME2wMlQxPjd2IN88US=> MUDTRW5ITVJ?
NCI-H1648 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;rXZBKSzVyPUCuOFQyQDJizszN MlrRV2FPT0WU
DU-145 NGG5SHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3e1PWlEPTB;MD60OFg{OyEQvF2= MlTHV2FPT0WU
CW-2 NFS2fYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUP3dpF7UUN3ME2wMlQ3QTF2IN88US=> NUXL[nd4W0GQR1XS
A431 NXjsWHAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUP2RVFzUUN3ME2wMlQ5OjN|IN88US=> M{K5TXNCVkeHUh?=
SAS NHf6cHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT5TWM2OD1yLkS4N|k5KM7:TR?= NIS0UYpUSU6JRWK=
NCI-H2126 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYGxZ|l7UUN3ME2wMlUyQTJ4IN88US=> M1[0SXNCVkeHUh?=
NCI-H358 NGDyXYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXNTWM2OD1yLkWzNlEh|ryP Ml3PV2FPT0WU
FADU MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Xze2lEPTB;MD61OFQxPCEQvF2= Mo\5V2FPT0WU
ACN MnTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7NTWM2OD1yLkW1NFk1KM7:TR?= MknEV2FPT0WU
HCC70 NHXleIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;GUnhSUUN3ME2wMlU4PjZzIN88US=> NYTheFc1W0GQR1XS
NCI-H1838 M1zqcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;mTWM2OD1yLk[wNlk6KM7:TR?= NW\ER|V6W0GQR1XS
CAL-54 NXvvOlM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwNkG2NlEh|ryP NVXFV3N2W0GQR1XS
NCI-H1975 NYTheGNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDuT5R1UUN3ME2wMlYyPzJ6IN88US=> NIXqWnpUSU6JRWK=
COR-L88 NXTXSmNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\BR2lEPTB;MD62OFEyOyEQvF2= MmiwV2FPT0WU
CTV-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\ZTWM2OD1yLk[0N|kzKM7:TR?= MXzTRW5ITVJ?
EW-18 NY\reY16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTOTWM2OD1yLk[4Olk5KM7:TR?= MlmwV2FPT0WU
HCC1806 NVrUUJh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTK[FJKSzVyPUCuOlk3PjZizszN MV3TRW5ITVJ?
HuP-T4 M3S1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17Hb2lEPTB;MD62PVc3KM7:TR?= MmC4V2FPT0WU
MDA-MB-361 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\POWlEPTB;MD63NlY3OiEQvF2= MVrTRW5ITVJ?
NCI-H1573 NFu5OoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ezcmlEPTB;MD63N|Y{KM7:TR?= MYHTRW5ITVJ?
KU-19-19 NIHUe3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwN{e0OlQh|ryP MWfTRW5ITVJ?
COLO-678 NY\6VVVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwOEC4N|Qh|ryP NF;R[XNUSU6JRWK=
C-33-A M2TmOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwOEGyPVch|ryP NULMUYVHW0GQR1XS
Calu-3 M3nxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwOEG0N|Qh|ryP NF\5UWhUSU6JRWK=
AGS Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nxRmlEPTB;MD64N|Y1QCEQvF2= MWLTRW5ITVJ?
SCC-25 NUnJPYhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fHfmlEPTB;MD64OFE4OSEQvF2= M2X0XnNCVkeHUh?=
JVM-2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S0R2lEPTB;MD64PFI6QSEQvF2= NF7jbY9USU6JRWK=
HCE-T NYjrXmt1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfzTWM2OD1yLki4OFI5KM7:TR?= NIPLboZUSU6JRWK=
ES4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwOUe4N|Yh|ryP MmT5V2FPT0WU
EKVX NVLWR4RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXmTItGUUN3ME2xMlAyODZ2IN88US=> MWHTRW5ITVJ?
D-542MG NUPifGROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmn4TWM2OD1zLkCxNFY1KM7:TR?= MY\TRW5ITVJ?
SW1116 NYL4Z5RQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\BcXVFUUN3ME2xMlAyOjh5IN88US=> MXHTRW5ITVJ?
5637 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TDSmlEPTB;MT6wNVUyKM7:TR?= NYDxUnJwW0GQR1XS
HT-1376 Mki0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3eweWlEPTB;MT6wNVUyOyEQvF2= MVfTRW5ITVJ?
NB69 M4DhOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT2TWM2OD1zLkCyPVQ2KM7:TR?= MlrxV2FPT0WU
YKG-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7vSHRKSzVyPUGuNFU1OTlizszN NX7DbGVvW0GQR1XS
EW-3 MmTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rlc2lEPTB;MT6wO|g5OyEQvF2= M4LxdHNCVkeHUh?=
GCIY NGLBU3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPHPXozUUN3ME2xMlA5OTB2IN88US=> M2C0PHNCVkeHUh?=
SK-MES-1 Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHnTWM2OD1zLkGxOFg4KM7:TR?= M2OxPXNCVkeHUh?=
PANC-08-13 M4fORmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrVVm1ZUUN3ME2xMlE3PDF4IN88US=> M33YNnNCVkeHUh?=
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Ca-Ski NVLsN5JwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nG[GlEPTB;Nz62OFI2QSEQvF2= Ml\TV2FPT0WU
HEL MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvtTWM2OD15LkexNlA{KM7:TR?= M{nwbXNCVkeHUh?=
NH-12 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzNTWM2OD15LkeyPFA5KM7:TR?= NWj2SHgyW0GQR1XS
LB373-MEL-D NFvve2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\TeWlEPTB;Nz63Olc4OSEQvF2= NWDEUo5iW0GQR1XS
SW900 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWOyTWc{UUN3ME23MlgzOTJzIN88US=> MUHTRW5ITVJ?
JVM-3 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7n[lFKSzVyPUeuPFk2QTlizszN M{HX[3NCVkeHUh?=
OAW-28 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTdwOUS1O|gh|ryP NXnPdZNYW0GQR1XS
KURAMOCHI MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4exOmlEPTB;Nz65OFgyOSEQvF2= MoDtV2FPT0WU
BE-13 MmHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLRelB{UUN3ME23Mlk5OTF{IN88US=> NUKyOmpOW0GQR1XS
VMRC-RCZ NUnNbZoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3j5TGlEPTB;OD6wNVY6PyEQvF2= MV\TRW5ITVJ?
NCI-H727 NWrLcndQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRThwMUC0NkDPxE1? NUnJb|BUW0GQR1XS
SW1710 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRThwMUi1NVUh|ryP M{C1SnNCVkeHUh?=
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NCI-H1993 NFPIdXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fwUWlEPTB;OD6zN|Y{OSEQvF2= NWq0XYF5W0GQR1XS
SCC-4 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;pPG9MUUN3ME24MlQ1ODV7IN88US=> NXLTNIs3W0GQR1XS
HAL-01 NIXlPXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXvVJE1UUN3ME24MlUyQTFizszN MX;TRW5ITVJ?
GT3TKB MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHSZmtKSzVyPUiuOlc6PjRizszN MW\TRW5ITVJ?
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COLO-829 NXXQfpFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vKdGlEPTB;OD64NFk4PiEQvF2= NVnXbXVNW0GQR1XS
OCI-AML2 NVHveYJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYm0VG5OUUN3ME24Mlk2PDhzIN88US=> MkLpV2FPT0WU
OS-RC-2 NYm4R4VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTlwMEKxPUDPxE1? M2rCTnNCVkeHUh?=
BFTC-909 MlLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILuXY5KSzVyPUmuNFY4QTlizszN MknzV2FPT0WU
EW-11 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTneIdDUUN3ME25MlE4PjV|IN88US=> MmPiV2FPT0WU
HCE-4 NVj4V|VUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTlwMkG1OVgh|ryP MnnKV2FPT0WU
BALL-1 Mn:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\pNGpKSzVyPUmuNlE6ODdizszN NWS4fVM5W0GQR1XS
SF539 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEi1S4lKSzVyPUmuNlM2PjJizszN MUfTRW5ITVJ?
CAMA-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\YTWM2OD17LkK4NVI5KM7:TR?= NHXCd5ZUSU6JRWK=
C32 NXjHPZNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\JWZV2UUN3ME25MlM{ODZ2IN88US=> M1OzRnNCVkeHUh?=
NCI-H1703 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvCTWM2OD17LkO0N|c2KM7:TR?= MVXTRW5ITVJ?
NCI-H1650 M1\NUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPLVFVKSzVyPUmuOlA6PDZizszN MnjzV2FPT0WU
NCI-H1563 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnjSHV7UUN3ME25Mlc3ODNzIN88US=> MorSV2FPT0WU
CAL-85-1 Mmj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoCzTWM2OD17Lki3N|g{KM7:TR?= MWLTRW5ITVJ?
UM-UC-3 NYTMOWdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1u3UmlEPTB;OT65OVA{KM7:TR?= M1vx[nNCVkeHUh?=
BxPC-3 NULib3pyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLsTWM2OD1zMD6wPVczKM7:TR?= NV7kXJFUW0GQR1XS
MHH-PREB-1 NIDVfplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT1TWM2OD1zMD6xPVk6KM7:TR?= NW\aWHZ{W0GQR1XS
DEL MkD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PwT2lEPTB;MUCuN|k1PiEQvF2= MmHlV2FPT0WU
HuCCT1 MlTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULTcZgzUUN3ME2xNE43ODN|IN88US=> NV\sWXVbW0GQR1XS
OVCAR-4 MorRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfDOGxvUUN3ME2xNE45QDN3IN88US=> NFezNZpUSU6JRWK=
CAL-72 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoeyTWM2OD1zMD65N|kyKM7:TR?= Mom3V2FPT0WU
HCC1954 NUjSfWdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nZSmlEPTB;MUGuNFc2PCEQvF2= NFTndW5USU6JRWK=
EFO-21 NF;YZVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[4N2lEPTB;MUGuNVA1PSEQvF2= NUT0ZndJW0GQR1XS
FTC-133 NHTOPW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrLWm5lUUN3ME2xNU4yPDB5IN88US=> Mn75V2FPT0WU
SK-MEL-24 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojHTWM2OD1zMT6yN|Y3KM7:TR?= M1raNnNCVkeHUh?=
UACC-62 MnzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPDTWM2OD1zMT6yN|Y5KM7:TR?= M1vUOnNCVkeHUh?=
NCI-H650 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTBdpB{UUN3ME2xNU4zPDF6IN88US=> MY\TRW5ITVJ?
ALL-PO MljkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTFzLkK1NVIh|ryP MlP3V2FPT0WU
T84 NH;Vd2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\hb2lEPTB;MUGuN|kxPyEQvF2= M1;zWHNCVkeHUh?=
IST-MEL1 NILLfXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWf2b2NFUUN3ME2xNU41PTV7IN88US=> NGXXflhUSU6JRWK=
SW626 MnH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjUTWM2OD1zMT61O|U2KM7:TR?= M2jDd3NCVkeHUh?=
RPMI-2650 MnG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1i2dWlEPTB;MUGuOVg5PSEQvF2= M1;aPXNCVkeHUh?=
MC-IXC M4nLSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH0[VNCUUN3ME2xNU43PzJ6IN88US=> NFvud2RUSU6JRWK=
HOP-62 NUDYO3FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTFzLk[3OlQh|ryP M4e4R3NCVkeHUh?=
NOS-1 NHjVV|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;T[G46UUN3ME2xNU44OTB7IN88US=> MYXTRW5ITVJ?
SW1573 M2WweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkn4TWM2OD1zMT63Nlk2KM7:TR?= MV\TRW5ITVJ?
WM-115 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4G0WmlEPTB;MUGuO|U5QCEQvF2= MVPTRW5ITVJ?
HuO9 NGKwU4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHNTWM2OD1zMT64O|c1KM7:TR?= MULTRW5ITVJ?
YAPC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnOenNvUUN3ME2xNU46OjV7IN88US=> MmjiV2FPT0WU
MDA-MB-453 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljSTWM2OD1zMT65OVE2KM7:TR?= MmHUV2FPT0WU
NCI-H596 MkC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L1bmlEPTB;MUKuNFM3QSEQvF2= NVzZNmYyW0GQR1XS
A172 M4XvV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[3d|JKSzVyPUGyMlA4QThizszN Mon0V2FPT0WU
RS4-11 Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTF{LkG3NlUh|ryP MVHTRW5ITVJ?
HCC1937 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nFVGlEPTB;MUKuO|U3PCEQvF2= M4XTbnNCVkeHUh?=
SW837 M2Lxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF{LkmwNlgh|ryP MmG4V2FPT0WU
NMC-G1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\Q[mlEPTB;MUKuPVI{PCEQvF2= MVLTRW5ITVJ?
PFSK-1 NXHjOWFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTF|LkC2JO69VQ>? M2nwdHNCVkeHUh?=
DBTRG-05MG NXfkeYtbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDCToFKSzVyPUGzMlA3OzJizszN MnzuV2FPT0WU
SK-UT-1 MkX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\VdmhKSzVyPUGzMlExQDNizszN MnHDV2FPT0WU
OVCAR-5 MkPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfTTWM2OD1zMz6xOVk{KM7:TR?= NGXzdINUSU6JRWK=
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SK-MEL-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTrNYRTUUN3ME2xN{44OTN3IN88US=> NF\pNZVUSU6JRWK=
LK-2 NYfVNWZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDXcHBKSzVyPUGzMlc3OzlizszN MY\TRW5ITVJ?
OE33 NGDleFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm1TWM2OD1zMz63PFYh|ryP MWDTRW5ITVJ?
Ramos-2G6-4C10 NV:y[opKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnj6TWM2OD1zND6wNlAzKM7:TR?= MYTTRW5ITVJ?
EW-13 NEDYTZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfrTWM2OD1zND6wN|UzKM7:TR?= MlfkV2FPT0WU
NCI-H1793 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDhTWM2OD1zND6yNFg4KM7:TR?= MWDTRW5ITVJ?
BHT-101 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonRTWM2OD1zND6yOFEh|ryP MVfTRW5ITVJ?
RKO NF;mWXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFO1XnVKSzVyPUG0MlUxPzVizszN NIrxNplUSU6JRWK=
NEC8 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkj2TWM2OD1zND61OFczKM7:TR?= M1XaNXNCVkeHUh?=
PANC-10-05 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjUTWM2OD1zND62NlQ4KM7:TR?= MnfCV2FPT0WU
NCI-H2030 Mki4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLhTWM2OD1zND62OFQ5KM7:TR?= MormV2FPT0WU
C2BBe1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjEe|ZKSzVyPUG0Mlc3PCEQvF2= Mn\hV2FPT0WU
EM-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoOwTWM2OD1zND64OVc3KM7:TR?= M1rSb3NCVkeHUh?=
HCC1395 NEjHUW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULDU2VLUUN3ME2xOE46OzN6IN88US=> NGe2PYhUSU6JRWK=
A2058 M33JWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PEfmlEPTB;MUWuNFQxQSEQvF2= MUTTRW5ITVJ?
SW1463 NGfldYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PsOmlEPTB;MUWuNFQ5PSEQvF2= NVrKTZhJW0GQR1XS
J82 M{Tic2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULVUWlOUUN3ME2xOU4xPTdizszN NV;sbmh[W0GQR1XS
CAL-120 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTF3LkG0OFch|ryP NIXLbm9USU6JRWK=
COLO-824 NYPnNWNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzzUWhKSzVyPUG1MlE2PzlizszN M2\BeXNCVkeHUh?=
LNCaP-Clone-FGC NVXHcmJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTndoYzUUN3ME2xOU41OjR6IN88US=> Mkn1V2FPT0WU
CP66-MEL NHzDUW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjpTWM2OD1zNT60Olg5KM7:TR?= NX\U[4RrW0GQR1XS
OC-314 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTF3LkS3NVQh|ryP M2rCOXNCVkeHUh?=
OVCAR-8 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonCTWM2OD1zNT64PFYyKM7:TR?= NYPmXXNLW0GQR1XS
MFE-280 M3TB[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnQbFI2UUN3ME2xOk4xPDh6IN88US=> MmPNV2FPT0WU
MHH-NB-11 NHj6U5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFThXHRKSzVyPUG2MlA5OzlizszN M1LOOHNCVkeHUh?=
SW1990 Mo\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTF4LkG3OVUh|ryP MVnTRW5ITVJ?
U-266 M1zuXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTF4LkKyPVkh|ryP MYHTRW5ITVJ?
MFM-223 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDjTWM2OD1zNj6zPVY2KM7:TR?= MlHUV2FPT0WU
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HH MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e0cGlEPTB;MU[uOVE3OiEQvF2= MVvTRW5ITVJ?
no-10 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTF4Lk[zOFMh|ryP M2\ONHNCVkeHUh?=
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NCI-H1092 MnHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTF4LkizNVYh|ryP MXPTRW5ITVJ?
MZ2-MEL MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXMU4FKUUN3ME2xOk45PDB|IN88US=> MmjtV2FPT0WU
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COLO-684 NIr5[2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWyOpB5UUN3ME2xOk46PDd5IN88US=> MX\TRW5ITVJ?
NCI-H661 M{\RNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmj6TWM2OD1zNj65Olk1KM7:TR?= NHS5TZVUSU6JRWK=
CP50-MEL-B M{LRXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTF5LkCzOFMh|ryP NXXxV3E3W0GQR1XS
NCI-H2405 NX;DWnhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jPc2lEPTB;MUeuNVk4PCEQvF2= MlS0V2FPT0WU
U-2-OS NGjUZmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fQSWlEPTB;MUeuOVMxPyEQvF2= M3vPbHNCVkeHUh?=
RERF-LC-MS NHrGdYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPTTWM2OD1zNz61OVA5KM7:TR?= M{PEUHNCVkeHUh?=
NCI-H2342 M{D2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXaO|hqUUN3ME2xO{42PTdizszN MkjOV2FPT0WU
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MOLT-16 NIryeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\NeGlEPTB;MUeuPFk{PCEQvF2= MWrTRW5ITVJ?
RH-18 NY\vSmFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\TTWM2OD1zOD6wNFM2KM7:TR?= NUnLOIJoW0GQR1XS
D-283MED MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jGXmlEPTB;MUiuNFA5QCEQvF2= MVvTRW5ITVJ?
RCC10RGB MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHWOlY2UUN3ME2xPE4xPTV7IN88US=> MVHTRW5ITVJ?
NCI-H1437 M1TnNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq2TWM2OD1zOD6xOlQyKM7:TR?= Mkf3V2FPT0WU
SW982 NFe2[HJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2D2VWlEPTB;MUiuNlY4OSEQvF2= NFXTPZFUSU6JRWK=
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ATN-1 M1fxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTN|LkG0NVYh|ryP MnLpV2FPT0WU
D-263MG MoPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlmwTWM2OD1|Mz64N|c5KM7:TR?= MnLLV2FPT0WU
LU-135 M4CybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjKXHFKSzVyPUOzMlg5OjlizszN MofwV2FPT0WU
C8166 NV3tb4t6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1SwbWlEPTB;M{OuPFg2PCEQvF2= M4jFWnNCVkeHUh?=
T-24 NGDDfWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTN2LkCyNFUh|ryP NVv1N4lpW0GQR1XS
Mewo NEjhOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTN2LkGzOFkh|ryP NYf4fIVZW0GQR1XS
22RV1 M3nzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUn4T|RIUUN3ME2zOE4yPzV2IN88US=> MX\TRW5ITVJ?
KM-H2 MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPNOVNRUUN3ME2zOE4yPzd7IN88US=> MnrUV2FPT0WU
NCI-H2122 MnKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTN2LkO0O|Eh|ryP M4X1O3NCVkeHUh?=
ABC-1 NHmxdHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG0TWM2OD1|ND6zOlk{KM7:TR?= M{nV[3NCVkeHUh?=
NCI-H1355 NF;RVJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTN2LkO4PFkh|ryP M2TPPXNCVkeHUh?=
NOMO-1 NF3GWXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXpfGpKSzVyPUO0MlU4ODNizszN NXT0PJUzW0GQR1XS
MZ7-mel MoSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTN2Lk[0PFch|ryP NEDyPHRUSU6JRWK=
NCI-H810 Mli3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPrTWM2OD1|ND63Nlc5KM7:TR?= NXSyeo97W0GQR1XS
D-392MG Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fm[GlEPTB;M{WuNFU3PSEQvF2= NXnBTpF1W0GQR1XS
LB771-HNC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIS4NXlKSzVyPUO1MlE3PThizszN MVjTRW5ITVJ?
COLO-679 NF;vdXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTN3LkO4PEDPxE1? MkDvV2FPT0WU
SK-PN-DW NYW0OopbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DpNmlEPTB;M{WuOFM3QSEQvF2= NHvVVZZUSU6JRWK=
VA-ES-BJ MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIW0OWlKSzVyPUO1MlQ3PDlizszN M4\MVnNCVkeHUh?=
KNS-42 NXjUTZhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTN3LkW4NlYh|ryP M1vIdXNCVkeHUh?=
RVH-421 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTN3Lke2OFUh|ryP MU\TRW5ITVJ?
P30-OHK NXHYVHN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILQNG1KSzVyPUO1Mlg4PTJizszN MYjTRW5ITVJ?
G-402 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDmO2M2UUN3ME2zOU46QDZ5IN88US=> M3KxSXNCVkeHUh?=
S-117 NX:4NFRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTN4LkOwNFgh|ryP NFPqUpZUSU6JRWK=
RXF393 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\xTWM2OD1|Nj6zO|g2KM7:TR?= NF61ZnNUSU6JRWK=
LCLC-103H NIjMSGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnHT204UUN3ME2zOk44QDB|IN88US=> NH\VcmJUSU6JRWK=
U-118-MG MknlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFThcW9KSzVyPUO2Mlg5PDdizszN NETEXWRUSU6JRWK=
8-MG-BA M2Xpb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7lT5NYUUN3ME2zOk46PDh|IN88US=> NVG2[YNRW0GQR1XS
MFH-ino MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn33TWM2OD1|Nz6zN|cyKM7:TR?= NEPaZZFUSU6JRWK=
NCI-H23 Ml7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzyb4JpUUN3ME2zO{41OTl4IN88US=> M2fSUXNCVkeHUh?=
NCI-H446 MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTN5LkS4OlIh|ryP NIXhZ5hUSU6JRWK=
LU-99A NH7Td3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jYRmlEPTB;M{euOVc{OSEQvF2= NIfKTG9USU6JRWK=
KP-N-YN NFvDUVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTN5Lk[xPVUh|ryP Mo\IV2FPT0WU
SCC-9 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LvXGlEPTB;M{euO|g{QCEQvF2= MVPTRW5ITVJ?
EFM-19 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTad2FKSzVyPUO3Mlc6PjdizszN MXrTRW5ITVJ?
A427 Ml2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvuNZBKSzVyPUO3MlkyODdizszN NI\4U2dUSU6JRWK=
LB831-BLC M3;OVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTN6Lk[wN|kh|ryP MYPTRW5ITVJ?
HOS MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTN7Lk[yO|Mh|ryP MVnTRW5ITVJ?
LAN-6 NWLWNm9rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjhVlBKSzVyPUSwMlAyOTJizszN MknDV2FPT0WU
U251 MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LIVGlEPTB;NECuOFA2PCEQvF2= MkHVV2FPT0WU
SNU-387 MorIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnROotJUUN3ME20NE41PTV|IN88US=> NHq0UFRUSU6JRWK=
DMS-79 NFezemNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTRyLkW4PFkh|ryP M2PuVHNCVkeHUh?=
SK-LU-1 NYrkPHI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PCcmlEPTB;NECuOlU3QCEQvF2= NUK4dWpMW0GQR1XS
HT NITn[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\OTWM2OD12MD62OlM6KM7:TR?= MWfTRW5ITVJ?
KP-N-YS MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPUTWM2OD12MD62O|Y5KM7:TR?= NI\sbFhUSU6JRWK=
DMS-114 NF;NS49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTBTWM2OD12MD64N|c1KM7:TR?= M17pW3NCVkeHUh?=
HUTU-80 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDqN5VKSzVyPUSxMlA2PjlizszN Mln4V2FPT0WU
ONS-76 MoqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTRzLkS3NFkh|ryP M1rSdHNCVkeHUh?=
A673 NHjNNHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTRzLkWxOVch|ryP NHy1V5JUSU6JRWK=
HPAF-II MnnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTyOohSUUN3ME20NU43PzB7IN88US=> NXHyNmN[W0GQR1XS
UACC-257 M4jPRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHjWlBiUUN3ME20NU44OzZ7IN88US=> M33CTXNCVkeHUh?=
EW-22 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTRzLki2PVch|ryP MnrNV2FPT0WU
NCI-H1755 NWnXSHZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TYdWlEPTB;NEGuPFczPSEQvF2= NV:xZW1jW0GQR1XS
KYSE-150 M2LYbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUGwXGs2UUN3ME20Nk4yPzh{IN88US=> MVrTRW5ITVJ?
CGTH-W-1 M4G2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLXWFFKSzVyPUSyMlQ6PTVizszN NFH6V2pUSU6JRWK=
NB13 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4qwSGlEPTB;NEKuOlIyPyEQvF2= M4jhO3NCVkeHUh?=
SW872 NIi4WXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TMSmlEPTB;NEKuOlM{OSEQvF2= NWf6UWRDW0GQR1XS
KP-4 M2Lj[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnNWZM{UUN3ME20Nk45QDN{IN88US=> Mnr5V2FPT0WU
HCC38 NXPMcpNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTR{Lkm2NVgh|ryP NEHCbVZUSU6JRWK=
BB49-HNC Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3RNVB3UUN3ME20N{4zOzV4IN88US=> NVqzbFh[W0GQR1XS
CAL-62 NIHkO2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoroTWM2OD12Mz60NFI5KM7:TR?= NI[0NFJUSU6JRWK=
NCI-H2029 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjmbndKSzVyPUSzMlU2QDFizszN NWnLSnRIW0GQR1XS
M14 Ml;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnnTWM2OD12ND6xN|MzKM7:TR?= MVvTRW5ITVJ?
COLO-680N M2rIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PJZmlEPTB;NESuN|M6KM7:TR?= NFnzUWxUSU6JRWK=
Hs-578-T MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTR3LkCyPVQh|ryP NYfsTYxGW0GQR1XS
MSTO-211H MnzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HpPWlEPTB;NEWuPVQ5OiEQvF2= M1\xOnNCVkeHUh?=
EW-1 MnjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlu0TWM2OD12NT65Olg6KM7:TR?= MWTTRW5ITVJ?
SW948 M164RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT0TWM2OD12Nj60OFYzKM7:TR?= MmTVV2FPT0WU
NCI-H460 NHnWfHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjBUndKSzVyPUS2MlUzOyEQvF2= MX3TRW5ITVJ?
CAS-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3lO|dKSzVyPUS2Mlc4ODFizszN MkCzV2FPT0WU
TGBC11TKB MlqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LUc2lEPTB;NEeuNVc4PyEQvF2= NIG4dWxUSU6JRWK=
HD-MY-Z NUDpb|JvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHYdWlKSzVyPUS4Mlc5PiEQvF2= M1zER3NCVkeHUh?=
NCI-H226 MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\xTWM2OD12OT63O|g2KM7:TR?= NVXTOmdRW0GQR1XS
PA-1 NUjWToI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmiwTWM2OD12OT64N|M2KM7:TR?= MYjTRW5ITVJ?
LB2518-MEL NHPwZYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLRPWI1UUN3ME20PU45PzJ|IN88US=> MnznV2FPT0WU
A101D NFW2V4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XT[WlEPTB;NEmuPVQzPSEQvF2= MmjVV2FPT0WU
NCI-H2087 MlvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTR7Lkm2PFIh|ryP NVO1XWwxW0GQR1XS

... Click to View More Cell Line Experimental Data

体内研究 活体研究时按实验对象体重,每千克口服20 mg BIBW2992持续25天,肿瘤产生明显的衰退现象,通过肿瘤切片的免疫组织化学染色观察发现,EGFR和AKT的磷酸化作用收到抑制。因此,正如lapatinib和neratinib, BIBW2992是次代酪氨酸激酶抑制剂,不可逆地抑制人类EGFR2(HER2)和EGFR激酶。BIBW2992不仅能和原代酪氨酸激酶如erlotinib和gefitinib一样有效抑制EGFR突变型,而且还能作用于抗erlotinib和gefitinib的EGFR。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

体外激酶活性实验:

人类EGFR和L858R/T790M双重突变型EGFR 的酪氨酸激酶区域与谷胱甘肽巯基转移酶区域相接,提取酪氨酸激酶区域的方法见补充说明。在有和没有BIBW2992时分别测定酶活。使用杆状病毒系统克隆HER2激酶,用类似提取EGFR激酶域的方法提取HER2激酶域。
细胞实验:

[1]

+ 展开
  • Cell lines: NSCLC细胞
  • Concentrations: 0-10 μM
  • Incubation Time: 1小时
  • Method:

    细胞按1×104密度转移到96孔板上,在无血清培养基上过夜培养,用于EGFR磷酸化实验。第二天添加包含BIBW2992的混合物,培养基在37oC温育1小时。在室温下用100 ng/ml EGF刺激10分钟。细胞用冰冻PBS冲洗,然后每孔用120 μl HEPEX buffer萃取,然后在室温下震荡1小时。每孔中所有2×104细胞都用于HER2磷酸化实验。在涂有链霉亲和素的板上加用封闭液按1:100比例稀释的抗EGFR的生物素和c-erb2/HER2肿瘤蛋白Ab-5-生物素。上述步骤得到的萃取物转移到有抗体包被的孔中,室温下温育1小时。彩色显影的测法见补充说明,吸光度为450纳米。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 雌性无胸腺NMRI-nu/nu鼠
  • Formulation: 0.5%甲基纤维素-0.4% Tween-80
  • Dosages: 20 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 485.94
化学式

C24H25ClFN5O3

CAS号 439081-18-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02795156 Recruiting Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma SCRI Development Innovations, LLC|Foundation Medicine|Boehringer Ingelheim|Bayer September 28, 2016 Phase 2
NCT03054038 Not yet recruiting Non-Small Cell Lung Carcinoma Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) February 2017 Phase 1
NCT02979977 Not yet recruiting Squamous Cell Cancers of the Head and Neck Aarti Bhatia|National Comprehensive Cancer Network|Boehringer Ingelheim|Yale University December 2016 Phase 2
NCT02876081 Not yet recruiting SMALL CELL LUNG CARCINOMA Groupe Hospitalier Paris Saint Joseph December 2016 Phase 2
NCT02183883 Recruiting Non-small Cell Lung Cancer University College, London|Boehringer Ingelheim December 2016 Phase 2
NCT02423525 Recruiting Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute October 2016 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFR Signaling Pathway Map

EGFR Inhibitors with Unique Features

相关EGFR产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID