Afatinib (BIBW2992)

目录号:S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992)不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。

规格 价格 库存 购买数量  
RMB 1964.25 现货
RMB 977.68 现货
RMB 1724.11 现货
RMB 4652.69 现货
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客户购买Selleck的此次产品后发表的文献37篇:

客户使用该产品的4个实验数据:

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

产品安全说明书

EGFR抑制剂选择性比较

生物活性

产品描述 Afatinib (BIBW2992)不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。
靶点
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
体外研究

BIBW2992不可逆地抑制EGFR/HER2,在体外作用于野生型EGFR ,L858R突变型EGFR, L858R/T790M 双突变型EGFR,及HER2时IC50分别为0.5, 0.4, 10, 14 nM。在体外实验中,BIBW2992不管作用于野生型EGFR/HER2还是突变型EGFR/HER2都显示出强大的活力,与gefitinib作用于L858R突变型EGFR的活力差不多,但是要比gefitinib 作用于L858R-T790M双突变型EGFR的活力大100倍。在体外,BIBW2992有效抑制所有实验类型细胞的EGFR/HER磷酸化作用。比如人类扁平上皮癌A431细胞系表达的野生型EGFR, 鼠类NIH-3T3细胞转染的野生型HER2 , 以及乳腺癌BT-474细胞系和胃癌NCI-N87细胞系表达的内源性HER2。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 Mn;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEC1O|Ih|ryP NHnaTWVUSU6JRWK=
KASUMI-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDJTVJKSzVyPUCuNFA6OTFizszN NIPWPIdUSU6JRWK=
HCC2218 Mk\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvV[YhLUUN3ME2wMlAxQTh5IN88US=> M4jxXnNCVkeHUh?=
KARPAS-45 MnH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HJeGlEPTB;MD6wNVY4OSEQvF2= M1;hOHNCVkeHUh?=
HSC-4 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rMWWlEPTB;MD6wNVc1QCEQvF2= NXTVT4RUW0GQR1XS
CHL-1 NGTqPFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDDTppKSzVyPUCuNFE5OzlizszN MkXkV2FPT0WU
KY821 NF;6OIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEKwOkDPxE1? NHjRfItUSU6JRWK=
NCI-N87 MmqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3FTWM2OD1yLkCyO|c{KM7:TR?= MkPRV2FPT0WU
DOK NHjQWHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nj[2lEPTB;MD6wN|E6PCEQvF2= MX;TRW5ITVJ?
DSH1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLUTWM2OD1yLkCzN|E1KM7:TR?= NWHUb2F7W0GQR1XS
MDA-MB-175-VII MnzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17mfmlEPTB;MD6wN|QyPiEQvF2= M{T0fXNCVkeHUh?=
NCI-H2170 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{L2XmlEPTB;MD6wN|czQCEQvF2= NFHnVI5USU6JRWK=
BT-474 M{\DUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYC0[FlnUUN3ME2wMlA1QTh4IN88US=> MWDTRW5ITVJ?
EFO-27 NGLXbnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkW4TWM2OD1yLkC1NVgzKM7:TR?= M360TXNCVkeHUh?=
NCI-H720 M{C3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf3NJpKSzVyPUCuNFU{OjVizszN MknLV2FPT0WU
PC-14 NX\VV3ZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEW2Olgh|ryP NIDndoxUSU6JRWK=
EC-GI-10 NH2wWpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIC0U2hKSzVyPUCuNFU6OTJizszN NX6xSGFFW0GQR1XS
KYSE-450 M3\kNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED1b45KSzVyPUCuNFU6PzhizszN M3XENnNCVkeHUh?=
BPH-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jFdmlEPTB;MD6wOVk5QCEQvF2= M{DxfHNCVkeHUh?=
NCI-H292 MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYq0XWFSUUN3ME2wMlA3ODlizszN NGnqXYdUSU6JRWK=
H9 NI\IfYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTyTWM2OD1yLkC3NVMzKM7:TR?= NUftWJRTW0GQR1XS
NCI-H526 NGPHXmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUOz[pJ5UUN3ME2wMlA4QDJ|IN88US=> NGnCcpRUSU6JRWK=
NCI-H1623 NWDpWWplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HWdWlEPTB;MD6wPFAzPSEQvF2= MUPTRW5ITVJ?
KYSE-140 NUjENnBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVizXIlpUUN3ME2wMlA5OzNizszN MnfvV2FPT0WU
Ca9-22 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEizOVMh|ryP M4LBN3NCVkeHUh?=
AU565 M2XTeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\iOoZUUUN3ME2wMlA5PTB2IN88US=> MV\TRW5ITVJ?
ZR-75-30 MkjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nlZmlEPTB;MD6wPVU1PSEQvF2= MnjQV2FPT0WU
NCI-H1770 M1ji[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYG2XpFZUUN3ME2wMlExOjhizszN MXvTRW5ITVJ?
LB2241-RCC Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfJU|RbUUN3ME2wMlExQDh2IN88US=> MmDuV2FPT0WU
CAL-39 M1O5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfkbZhKSzVyPUCuNVE4QTJizszN NV:4No95W0GQR1XS
UACC-893 NVzxWHpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIKyNXdKSzVyPUCuNVE5QDVizszN M2\OfnNCVkeHUh?=
LU-65 MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnX1TWM2OD1yLkGyOlM{KM7:TR?= MnrCV2FPT0WU
HN M3;weGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH60UYVKSzVyPUCuNVMxPzdizszN NV\lUIZrW0GQR1XS
TI-73 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NESxWHpKSzVyPUCuNVQ4OTVizszN MnHrV2FPT0WU
KU812 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Lt[2lEPTB;MD6xOVQ2PiEQvF2= NESzR4RUSU6JRWK=
SW13 M3fv[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzSOY1KSzVyPUCuNVYzOTZizszN NF:zb|hUSU6JRWK=
BB30-HNC NWPwTYRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMU[1O|Yh|ryP M1KxZ3NCVkeHUh?=
HSC-2 M37zc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjMO4JTUUN3ME2wMlE3QDN5IN88US=> M13Z[nNCVkeHUh?=
BV-173 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPhfY1KSzVyPUCuNVc2QTZizszN MoHxV2FPT0WU
CAL-27 MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13FOGlEPTB;MD6xO|Y{PiEQvF2= MlnSV2FPT0WU
SBC-1 NYi5XVQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDjXGRFUUN3ME2wMlE5QTV7IN88US=> NF[y[VNUSU6JRWK=
CAL-33 MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvJeo9KSzVyPUCuNlAyQDRizszN MYnTRW5ITVJ?
NCI-H209 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMkC0OkDPxE1? NWTO[I9qW0GQR1XS
COR-L105 NX74[HR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILodnVKSzVyPUCuNlExQDRizszN Mm\FV2FPT0WU
HSC-3 MoPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fwTGlEPTB;MD6yNVE6QCEQvF2= NYix[FRjW0GQR1XS
NCI-H69 NXfybpplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPjd2FKSzVyPUCuNlE1PTFizszN M4mwNXNCVkeHUh?=
MOLT-13 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPrU3gyUUN3ME2wMlI{QTd3IN88US=> NFHl[JZUSU6JRWK=
ML-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HSemlEPTB;MD6yOFgxOiEQvF2= NIq5OG1USU6JRWK=
IGROV-1 MkfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXtTWM2OD1yLkK1PVUzKM7:TR?= NFPOTJZUSU6JRWK=
TK10 Mo\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMk[3N|gh|ryP NFzsTIdUSU6JRWK=
EoL-1-cell Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LBO2lEPTB;MD6yOlg6OiEQvF2= MkLBV2FPT0WU
HO-1-N-1 NHrUSVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[1U2NKSzVyPUCuNlc5PTNizszN NXLvUZllW0GQR1XS
BHY MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\aO|hOUUN3ME2wMlI5PjV3IN88US=> MoXQV2FPT0WU
LU-139 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPURW5lUUN3ME2wMlMxPTFizszN NXfqRoJEW0GQR1XS
23132-87 MmHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofnTWM2OD1yLkOxPVI{KM7:TR?= M1;M[3NCVkeHUh?=
ACHN MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwM{G5PVQh|ryP NWTF[FlQW0GQR1XS
DoTc2-4510 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fUPGlEPTB;MD6zNlIyQSEQvF2= NIfpPYlUSU6JRWK=
BB65-RCC MmGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnpfZBRUUN3ME2wMlM1PTl|IN88US=> MU\TRW5ITVJ?
HLE NYfmPHIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHZdGRKSzVyPUCuN|UxPDZizszN MULTRW5ITVJ?
HCC1419 M17xT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfoXWt2UUN3ME2wMlM3PDB6IN88US=> NHjTTYZUSU6JRWK=
A388 NIrV[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjxU2JWUUN3ME2wMlM3QDV5IN88US=> NVfQcVJyW0GQR1XS
NUGC-3 M{m3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnETWM2OD1yLkO4N|c{KM7:TR?= M3SxbnNCVkeHUh?=
KYSE-180 NX7QfFdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17oWWlEPTB;MD6zPVA5QSEQvF2= MorkV2FPT0WU
TE-6 NFLNOpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3GO5dTUUN3ME2wMlQxOjR4IN88US=> Mor1V2FPT0WU
A498 NVzpenNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3oTWM2OD1yLkSwOlc1KM7:TR?= MWfTRW5ITVJ?
NCI-H1648 M2rO[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwNESxPFIh|ryP NVThNFZxW0GQR1XS
DU-145 M33nVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnOTWM2OD1yLkS0PFM{KM7:TR?= MXPTRW5ITVJ?
CW-2 NID3TJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki0TWM2OD1yLkS2PVE1KM7:TR?= MlfaV2FPT0WU
A431 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknKTWM2OD1yLkS4NlM{KM7:TR?= NF3ZbIVUSU6JRWK=
SAS MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTzZZhjUUN3ME2wMlQ5Ozl6IN88US=> NWrpdIpQW0GQR1XS
NCI-H2126 NILWWVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrNTIFKSzVyPUCuOVE6OjZizszN NGX3NnZUSU6JRWK=
NCI-H358 NH;0WY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTPdY5xUUN3ME2wMlU{OjFizszN MVPTRW5ITVJ?
FADU NVnkenptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjhTWM2OD1yLkW0OFA1KM7:TR?= Mm\RV2FPT0WU
ACN MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwNUWwPVQh|ryP MkDpV2FPT0WU
HCC70 NIrMTZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwNUe2OlEh|ryP NYj2ZmpZW0GQR1XS
NCI-H1838 NFS1b2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nwSmlEPTB;MD62NFI6QSEQvF2= NVvyVVYzW0GQR1XS
CAL-54 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PH[2lEPTB;MD62NVYzOSEQvF2= M1XobXNCVkeHUh?=
NCI-H1975 NH7SdWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIC1O3FKSzVyPUCuOlE4OjhizszN NYHt[XA5W0GQR1XS
COR-L88 MnPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XWS2lEPTB;MD62OFEyOyEQvF2= NGfXVmVUSU6JRWK=
CTV-1 M13LVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwNkSzPVIh|ryP NGn3dnpUSU6JRWK=
EW-18 NX75UZQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\URXVJUUN3ME2wMlY5Pjl6IN88US=> M4jZUHNCVkeHUh?=
HCC1806 NF3CSFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TrVWlEPTB;MD62PVY3PiEQvF2= MYrTRW5ITVJ?
HuP-T4 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwNkm3OkDPxE1? Ml3QV2FPT0WU
MDA-MB-361 NWTid3F3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwN{K2OlIh|ryP MlHTV2FPT0WU
NCI-H1573 NHrUfpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIm3SodKSzVyPUCuO|M3OyEQvF2= M3PYOnNCVkeHUh?=
KU-19-19 NIXqSXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHyN2RVUUN3ME2wMlc4PDZ2IN88US=> NFSwXXNUSU6JRWK=
COLO-678 M4LaWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HzSmlEPTB;MD64NFg{PCEQvF2= MlLmV2FPT0WU
C-33-A NEHLN2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUH6NlZtUUN3ME2wMlgyOjl5IN88US=> MYjTRW5ITVJ?
Calu-3 M4nZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwOEG0N|Qh|ryP NVXv[FczW0GQR1XS
AGS MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfwSnhKSzVyPUCuPFM3PDhizszN NFf0RVJUSU6JRWK=
SCC-25 NFTpUlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LBPWlEPTB;MD64OFE4OSEQvF2= M2r4TnNCVkeHUh?=
JVM-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwOEiyPVkh|ryP NInGXldUSU6JRWK=
HCE-T NWjoflVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkWzTWM2OD1yLki4OFI5KM7:TR?= NF74e5ZUSU6JRWK=
ES4 NEOxO2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwOUe4N|Yh|ryP M2i4R3NCVkeHUh?=
EKVX NIn3TGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT3TWM2OD1zLkCxNFY1KM7:TR?= MVPTRW5ITVJ?
D-542MG MnK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fI[GlEPTB;MT6wNVA3PCEQvF2= NVn1O5JOW0GQR1XS
SW1116 NUfnVXVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPRV2JKSzVyPUGuNFEzQDdizszN MXjTRW5ITVJ?
5637 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmm0TWM2OD1zLkCxOVEh|ryP M4PxOXNCVkeHUh?=
HT-1376 NV\mb5hTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDqTWM2OD1zLkCxOVE{KM7:TR?= MVzTRW5ITVJ?
NB69 NI\rWZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF6wdWNKSzVyPUGuNFI6PDVizszN NYXPZlVzW0GQR1XS
YKG-1 NV\sUWhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\lVGlEPTB;MT6wOVQyQSEQvF2= M{TaXHNCVkeHUh?=
EW-3 MoHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTFwMEe4PFMh|ryP NH[2ToNUSU6JRWK=
GCIY MknXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFwMEixNFQh|ryP M33RPHNCVkeHUh?=
SK-MES-1 NHvGOo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jjcmlEPTB;MT6xNVQ5PyEQvF2= MlXxV2FPT0WU
PANC-08-13 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjrbWxQUUN3ME2xMlE3PDF4IN88US=> MXPTRW5ITVJ?
SK-NEP-1 MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LyPWlEPTB;MT6xO|UyOyEQvF2= NUXZSnpyW0GQR1XS
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HEL MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX3VFdFUUN3ME23MlcyOjB|IN88US=> MmKxV2FPT0WU
NH-12 MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr6VoJ5UUN3ME23MlczQDB6IN88US=> NGC3cI9USU6JRWK=
LB373-MEL-D MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;QNodNUUN3ME23Mlc3PzdzIN88US=> MWDTRW5ITVJ?
SW900 MkLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfnW3NKSzVyPUeuPFIyOjFizszN MWPTRW5ITVJ?
JVM-3 NE[5PWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjsbmJKSzVyPUeuPFk2QTlizszN NWDQZ29GW0GQR1XS
OAW-28 M3fmNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TVPWlEPTB;Nz65OFU4QCEQvF2= M2fW[XNCVkeHUh?=
KURAMOCHI NVziZYxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmj2TWM2OD15Lkm0PFEyKM7:TR?= MWrTRW5ITVJ?
BE-13 NF7kd2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTdwOUixNVIh|ryP Mn;PV2FPT0WU
VMRC-RCZ NImzOJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{WzXWlEPTB;OD6wNVY6PyEQvF2= MWXTRW5ITVJ?
NCI-H727 NHjCdJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRThwMUC0NkDPxE1? Ml3KV2FPT0WU
SW1710 MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\3TWM2OD16LkG4OVE2KM7:TR?= Mm[5V2FPT0WU
D-502MG NX\yW2xxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPBZ|FKSzVyPUiuNlkzQDJizszN M1TqU3NCVkeHUh?=
NCI-H1993 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvSSlFKSzVyPUiuN|M3OzFizszN MV\TRW5ITVJ?
SCC-4 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2npbGlEPTB;OD60OFA2QSEQvF2= MmL1V2FPT0WU
HAL-01 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFH2SnRKSzVyPUiuOVE6OSEQvF2= Ml;QV2FPT0WU
GT3TKB NVSw[3M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;teGlEPTB;OD62O|k3PCEQvF2= MWrTRW5ITVJ?
SK-OV-3 M4TBW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRThwN{GzNlkh|ryP NHm0O5lUSU6JRWK=
COLO-829 NUWzbWpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DKW2lEPTB;OD64NFk4PiEQvF2= MoXzV2FPT0WU
OCI-AML2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DRdGlEPTB;OD65OVQ5OSEQvF2= NX7RVVR1W0GQR1XS
OS-RC-2 NVH0eG42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXzTWM2OD17LkCyNVkh|ryP M2\ufHNCVkeHUh?=
BFTC-909 M1j2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vOb2lEPTB;OT6wOlc6QSEQvF2= M2HO[HNCVkeHUh?=
EW-11 M3TIbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTlwMUe2OVMh|ryP NGjhfYNUSU6JRWK=
HCE-4 MmfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH3fIdjUUN3ME25MlIyPTV6IN88US=> MWDTRW5ITVJ?
BALL-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LiSmlEPTB;OT6yNVkxPyEQvF2= NF21blFUSU6JRWK=
SF539 M4e1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVezNJprUUN3ME25MlI{PTZ{IN88US=> Mom1V2FPT0WU
CAMA-1 NUDi[3ljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjOU2NKSzVyPUmuNlgyOjhizszN MnqzV2FPT0WU
C32 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTsN3RPUUN3ME25MlM{ODZ2IN88US=> NIP3PG1USU6JRWK=
NCI-H1703 NITNeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\NeWVKSzVyPUmuN|Q{PzVizszN MoLFV2FPT0WU
NCI-H1650 M3PUTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTlwNkC5OFYh|ryP M1Xsb3NCVkeHUh?=
NCI-H1563 NETBNmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoexTWM2OD17Lke2NFMyKM7:TR?= NFW5O3NUSU6JRWK=
CAL-85-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DvdWlEPTB;OT64O|M5OyEQvF2= M3;5RnNCVkeHUh?=
UM-UC-3 NVnpOWpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3m3OmlEPTB;OT65OVA{KM7:TR?= MlPFV2FPT0WU
BxPC-3 M4fQVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGW2d21KSzVyPUGwMlA6PzJizszN NXnJO4hFW0GQR1XS
MHH-PREB-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[zTWM2OD1zMD6xPVk6KM7:TR?= MlXDV2FPT0WU
DEL MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fYOmlEPTB;MUCuN|k1PiEQvF2= Mn7ZV2FPT0WU
HuCCT1 NV;iTJFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfDTWM2OD1zMD62NFM{KM7:TR?= NFPlRnpUSU6JRWK=
OVCAR-4 Ml;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rQU2lEPTB;MUCuPFg{PSEQvF2= M334PXNCVkeHUh?=
CAL-72 NF[yeYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWG3Spl5UUN3ME2xNE46OzlzIN88US=> NUSxbVVOW0GQR1XS
HCC1954 MonuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTFzLkC3OVQh|ryP Mn7zV2FPT0WU
EFO-21 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfjO3Z1UUN3ME2xNU4yODR3IN88US=> NX74flRnW0GQR1XS
FTC-133 M4HKTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mle5TWM2OD1zMT6xOFA4KM7:TR?= NVvKWoROW0GQR1XS
SK-MEL-24 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWO1VXFXUUN3ME2xNU4zOzZ4IN88US=> MV;TRW5ITVJ?
UACC-62 NXj4OXl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTFzLkKzOlgh|ryP Mnj2V2FPT0WU
NCI-H650 NIXXRVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTFzLkK0NVgh|ryP NIW0N5JUSU6JRWK=
ALL-PO MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3jWnhKSzVyPUGxMlI2OTJizszN NHvVbWlUSU6JRWK=
T84 MkLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPITWM2OD1zMT6zPVA4KM7:TR?= NWe2d|VGW0GQR1XS
IST-MEL1 NV;iSmpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHVSYxKSzVyPUGxMlQ2PTlizszN MVPTRW5ITVJ?
SW626 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;XPWlEPTB;MUGuOVc2PSEQvF2= NH[0NHVUSU6JRWK=
RPMI-2650 NIPq[WlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX0UmtUUUN3ME2xNU42QDh3IN88US=> Mn;ZV2FPT0WU
MC-IXC NHzldnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLnTWM2OD1zMT62O|I5KM7:TR?= NXK3[Y4zW0GQR1XS
HOP-62 M3Pkd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTFzLk[3OlQh|ryP NFjEOmxUSU6JRWK=
NOS-1 M1LaPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\oWmlEPTB;MUGuO|ExQSEQvF2= MoiyV2FPT0WU
SW1573 M2i0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPyZZFKSzVyPUGxMlczQTVizszN M2izdXNCVkeHUh?=
WM-115 MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYGyVoJQUUN3ME2xNU44PTh6IN88US=> MmnTV2FPT0WU
HuO9 NWXDS2p3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmmwTWM2OD1zMT64O|c1KM7:TR?= NHnxXGJUSU6JRWK=
YAPC M124ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVyxOnNwUUN3ME2xNU46OjV7IN88US=> M1LLVXNCVkeHUh?=
MDA-MB-453 NXvWXHZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTqR49qUUN3ME2xNU46PTF3IN88US=> MV;TRW5ITVJ?
NCI-H596 NGrHVWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVniXYczUUN3ME2xNk4xOzZ7IN88US=> NYix[VN[W0GQR1XS
A172 NVfoS3ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7sTWM2OD1zMj6wO|k5KM7:TR?= MkPpV2FPT0WU
RS4-11 NV73U|lzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTF{LkG3NlUh|ryP NXW1[o91W0GQR1XS
HCC1937 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnzTWM2OD1zMj63OVY1KM7:TR?= NITvcmhUSU6JRWK=
SW837 M3\SZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\mRYxKSzVyPUGyMlkxOjhizszN M2TBPXNCVkeHUh?=
NMC-G1 MlnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7Bcm5tUUN3ME2xNk46OjN2IN88US=> MmDVV2FPT0WU
PFSK-1 MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHxTWM2OD1zMz6wOkDPxE1? M1zTR3NCVkeHUh?=
DBTRG-05MG MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmi1TWM2OD1zMz6wOlMzKM7:TR?= MYPTRW5ITVJ?
SK-UT-1 NGf2cWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlqwTWM2OD1zMz6xNFg{KM7:TR?= NYOwO|lKW0GQR1XS
OVCAR-5 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHsTWM2OD1zMz6xOVk{KM7:TR?= NIeyXmVUSU6JRWK=
8505C M3H3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHLdHY1UUN3ME2xN{4zODZ5IN88US=> NI\ob2hUSU6JRWK=
SK-MEL-1 Mnz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF|LkexN|Uh|ryP MmrYV2FPT0WU
LK-2 M3LQZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3JcXQxUUN3ME2xN{44PjN7IN88US=> NEfiVlNUSU6JRWK=
OE33 MlT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3nTWM2OD1zMz63PFYh|ryP MV3TRW5ITVJ?
Ramos-2G6-4C10 Mn7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEX4TIdKSzVyPUG0MlAzODJizszN M4LPSHNCVkeHUh?=
EW-13 NXm0Xo1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTF2LkCzOVIh|ryP NVm1SYczW0GQR1XS
NCI-H1793 M2Pa[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLsbphKSzVyPUG0MlIxQDdizszN NFj1Z|ZUSU6JRWK=
BHT-101 MmH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInkO4NKSzVyPUG0MlI1OSEQvF2= MmH4V2FPT0WU
RKO MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\IN2lEPTB;MUSuOVA4PSEQvF2= MkHEV2FPT0WU
NEC8 NV70WXl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTF2LkW0O|Ih|ryP NHPYeYxUSU6JRWK=
PANC-10-05 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4[4VGlEPTB;MUSuOlI1PyEQvF2= NUD5ZVZSW0GQR1XS
NCI-H2030 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF2Lk[0OFgh|ryP NYrnfmR3W0GQR1XS
C2BBe1 M13ERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\pTWM2OD1zND63OlQh|ryP M1nRTXNCVkeHUh?=
EM-2 NHvtcI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHznZ2hKSzVyPUG0Mlg2PzZizszN NH[5cJZUSU6JRWK=
HCC1395 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zJd2lEPTB;MUSuPVM{QCEQvF2= M3jqWXNCVkeHUh?=
A2058 NWPqXZJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTF3LkC0NFkh|ryP MoXIV2FPT0WU
SW1463 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DI[2lEPTB;MUWuNFQ5PSEQvF2= NW[0R5BlW0GQR1XS
J82 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jYWWlEPTB;MUWuNFU4KM7:TR?= M4\jVHNCVkeHUh?=
CAL-120 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDRZYZKSzVyPUG1MlE1PDdizszN NYTZUGg3W0GQR1XS
COLO-824 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTF3LkG1O|kh|ryP MXPTRW5ITVJ?
LNCaP-Clone-FGC NVHHXoFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TEVGlEPTB;MUWuOFI1QCEQvF2= NITOZ2RUSU6JRWK=
CP66-MEL MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7tSY5KSzVyPUG1MlQ3QDhizszN Mm\WV2FPT0WU
OC-314 NFTWT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPCTWM2OD1zNT60O|E1KM7:TR?= MlO4V2FPT0WU
OVCAR-8 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXac2RVUUN3ME2xOU45QDZzIN88US=> NVPnW4V[W0GQR1XS
MFE-280 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTF4LkC0PFgh|ryP MVPTRW5ITVJ?
MHH-NB-11 NUXBdFBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH3VIZKSzVyPUG2MlA5OzlizszN MUfTRW5ITVJ?
SW1990 MnLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF4LkG3OVUh|ryP NX7SZ|hyW0GQR1XS
U-266 M3q3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonOTWM2OD1zNj6yNlk6KM7:TR?= M{LPcXNCVkeHUh?=
MFM-223 NHn1SIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV20PIk5UUN3ME2xOk4{QTZ3IN88US=> NYj3ToVjW0GQR1XS
L-363 M1;pS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF4LkS1O|ch|ryP M2DYbXNCVkeHUh?=
MCF7 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofHTWM2OD1zNj60O|I{KM7:TR?= MlSyV2FPT0WU
SK-MEL-3 Mn:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTF4LkS3PFch|ryP MWLTRW5ITVJ?
HH NFXkWIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXwfYNKSzVyPUG2MlUyPjJizszN MYjTRW5ITVJ?
no-10 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDJcHllUUN3ME2xOk43OzR|IN88US=> M3\3bnNCVkeHUh?=
HuP-T3 Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvxcmdMUUN3ME2xOk43PTd4IN88US=> MV7TRW5ITVJ?
QIMR-WIL MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTF4LkexNFUh|ryP NVHWZnZkW0GQR1XS
NCI-H1092 M2PDbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHJPVJCUUN3ME2xOk45OzF4IN88US=> M3rkenNCVkeHUh?=
MZ2-MEL M3zZ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojtTWM2OD1zNj64OFA{KM7:TR?= NFTKcVdUSU6JRWK=
ES3 Mn[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF4LkmxN|Qh|ryP NWTiSGdTW0GQR1XS
COLO-684 NHnZe2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF4Lkm0O|ch|ryP M2fNcXNCVkeHUh?=
NCI-H661 MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTaSmh1UUN3ME2xOk46Pjl2IN88US=> NXmyZ241W0GQR1XS
CP50-MEL-B MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF5LkCzOFMh|ryP NWS4flVNW0GQR1XS
NCI-H2405 MkC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnrSVNLUUN3ME2xO{4yQTd2IN88US=> NIK2b3ZUSU6JRWK=
U-2-OS MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1qwe2lEPTB;MUeuOVMxPyEQvF2= NXrzbpJoW0GQR1XS
RERF-LC-MS NHXYco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF5LkW1NFgh|ryP NH7YeYpUSU6JRWK=
NCI-H2342 MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDLd2p{UUN3ME2xO{42PTdizszN MXvTRW5ITVJ?
ES8 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTF5Lk[wPFch|ryP NFzKVHlUSU6JRWK=
MOLT-16 Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojkTWM2OD1zNz64PVM1KM7:TR?= NHvWbmVUSU6JRWK=
RH-18 M3zPe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LPV2lEPTB;MUiuNFA{PSEQvF2= NV\vepBwW0GQR1XS
D-283MED MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vGfGlEPTB;MUiuNFA5QCEQvF2= NFLRUmlUSU6JRWK=
RCC10RGB MmS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LkeWlEPTB;MUiuNFU2QSEQvF2= M{XK[3NCVkeHUh?=
NCI-H1437 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTF6LkG2OFEh|ryP MVvTRW5ITVJ?
SW982 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHznVWFKSzVyPUG4MlI3PzFizszN MXXTRW5ITVJ?
IST-MES1 MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXablZKSzVyPUG4MlQ1OjhizszN MVXTRW5ITVJ?
A704 NGe1T4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXZO497UUN3ME2xPE41PzV|IN88US=> MWDTRW5ITVJ?
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C8166 NYnUdGNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTN|Lki4OVQh|ryP MXzTRW5ITVJ?
T-24 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe4flBKSzVyPUO0MlAzODVizszN M{fEe3NCVkeHUh?=
Mewo NHnxUZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3m5e2lEPTB;M{SuNVM1QSEQvF2= NYi2[lQyW0GQR1XS
22RV1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLVT3U5UUN3ME2zOE4yPzV2IN88US=> M3;ObHNCVkeHUh?=
KM-H2 NY\GVYVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rkNWlEPTB;M{SuNVc4QSEQvF2= NEH3bpdUSU6JRWK=
NCI-H2122 NE\uWGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDaTJlZUUN3ME2zOE4{PDdzIN88US=> M{HMTXNCVkeHUh?=
ABC-1 M3PqR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK3NIVKSzVyPUO0MlM3QTNizszN NW\icpU2W0GQR1XS
NCI-H1355 NEPVNopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu0NFZKSzVyPUO0MlM5QDlizszN M1\EWXNCVkeHUh?=
NOMO-1 NUfLbVVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv6Z5d6UUN3ME2zOE42PzB|IN88US=> MnPsV2FPT0WU
MZ7-mel NVvBV45OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7JcZZiUUN3ME2zOE43PDh5IN88US=> NIjBSpZUSU6JRWK=
NCI-H810 NXfIcodRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HTbmlEPTB;M{SuO|I4QCEQvF2= MlnNV2FPT0WU
D-392MG NYnKcnE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TpU2lEPTB;M{WuNFU3PSEQvF2= MmSwV2FPT0WU
LB771-HNC MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\rTYpKSzVyPUO1MlE3PThizszN MkXGV2FPT0WU
COLO-679 M2Ticmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTN3LkO4PEDPxE1? NGrtWm9USU6JRWK=
SK-PN-DW NU\hSFVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvuPYpQUUN3ME2zOU41OzZ7IN88US=> Ml7iV2FPT0WU
VA-ES-BJ MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLWTWM2OD1|NT60OlQ6KM7:TR?= MVvTRW5ITVJ?
KNS-42 Mmr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDMdGJ6UUN3ME2zOU42QDJ4IN88US=> MkLKV2FPT0WU
RVH-421 NHzIeIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTN3Lke2OFUh|ryP NH\OZotUSU6JRWK=
P30-OHK NWHJfmRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTN3Lki3OVIh|ryP M{jzNXNCVkeHUh?=
G-402 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILFd3ZKSzVyPUO1Mlk5PjdizszN M2TpTnNCVkeHUh?=
S-117 NVrKdo5MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4i1WWlEPTB;M{[uN|AxQCEQvF2= NWTmPXprW0GQR1XS
RXF393 Ml;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XOWGlEPTB;M{[uN|c5PSEQvF2= M2CzU3NCVkeHUh?=
LCLC-103H MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjNUmNKSzVyPUO2Mlc5ODNizszN NH3rVo9USU6JRWK=
U-118-MG MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTN4Lki4OFch|ryP NUHpfnFqW0GQR1XS
8-MG-BA MkD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX1eVVKSzVyPUO2Mlk1QDNizszN M1PIZXNCVkeHUh?=
MFH-ino M4\pcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTN5LkOzO|Eh|ryP NHuxSHBUSU6JRWK=
NCI-H23 M3;Hc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF25OmJKSzVyPUO3MlQyQTZizszN M4f3dnNCVkeHUh?=
NCI-H446 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHibYg5UUN3ME2zO{41QDZ{IN88US=> MWLTRW5ITVJ?
LU-99A M3npTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS2NJNKSzVyPUO3MlU4OzFizszN MlfDV2FPT0WU
KP-N-YN MkTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{G5[WlEPTB;M{euOlE6PSEQvF2= MnLZV2FPT0WU
SCC-9 MmrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;YOJVKSzVyPUO3Mlc5OzhizszN M1SxUnNCVkeHUh?=
EFM-19 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTN5Lke5Olch|ryP NVn5emlSW0GQR1XS
A427 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTN5LkmxNFch|ryP NXjzU4t6W0GQR1XS
LB831-BLC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2C0fWlEPTB;M{iuOlA{QSEQvF2= NXLw[FRHW0GQR1XS
HOS MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1G0c2lEPTB;M{muOlI4OyEQvF2= M{[2RXNCVkeHUh?=
LAN-6 MnTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDXWIJKSzVyPUSwMlAyOTJizszN NGOxToZUSU6JRWK=
U251 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TWZ2lEPTB;NECuOFA2PCEQvF2= M4LhcXNCVkeHUh?=
SNU-387 NGfBT5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTRyLkS1OVMh|ryP MX3TRW5ITVJ?
DMS-79 M1HTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTRyLkW4PFkh|ryP M3LwN3NCVkeHUh?=
SK-LU-1 NVHBWoVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;pcGlEPTB;NECuOlU3QCEQvF2= NV7mfmVIW0GQR1XS
HT M3n0cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTRyLk[2N|kh|ryP MnLYV2FPT0WU
KP-N-YS MnrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjDSpFKSzVyPUSwMlY4PjhizszN MWrTRW5ITVJ?
DMS-114 Ml\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzIRVVKSzVyPUSwMlg{PzRizszN M{G5cXNCVkeHUh?=
HUTU-80 Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHKTWM2OD12MT6wOVY6KM7:TR?= NF2xdpRUSU6JRWK=
ONS-76 NWLtNWg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P6NGlEPTB;NEGuOFcxQSEQvF2= M1nqcnNCVkeHUh?=
A673 M4XseWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTRzLkWxOVch|ryP MVzTRW5ITVJ?
HPAF-II MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\HNFZrUUN3ME20NU43PzB7IN88US=> MUTTRW5ITVJ?
UACC-257 MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTRzLkezOlkh|ryP MljiV2FPT0WU
EW-22 NY\XdIpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fhNmlEPTB;NEGuPFY6PyEQvF2= NF7jRmpUSU6JRWK=
NCI-H1755 M4TJbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;QbGRKSzVyPUSxMlg4OjVizszN MlXlV2FPT0WU
KYSE-150 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTR{LkG3PFIh|ryP M2DOd3NCVkeHUh?=
CGTH-W-1 NGj5W5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTR{LkS5OVUh|ryP MnHDV2FPT0WU
NB13 MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTR{Lk[yNVch|ryP NWPSdWh2W0GQR1XS
SW872 NE[3UZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTR{Lk[zN|Eh|ryP M4TWfHNCVkeHUh?=
KP-4 M1S2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTv[JFIUUN3ME20Nk45QDN{IN88US=> MlvZV2FPT0WU
HCC38 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nkWGlEPTB;NEKuPVYyQCEQvF2= NWnGdHpjW0GQR1XS
BB49-HNC MmrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLyR3FKSzVyPUSzMlI{PTZizszN M{jicXNCVkeHUh?=
CAL-62 NUDVXI5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;YWFJQUUN3ME20N{41ODJ6IN88US=> MYLTRW5ITVJ?
NCI-H2029 M3:wO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fITGlEPTB;NEOuOVU5OSEQvF2= M1T4bnNCVkeHUh?=
M14 M1f3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDjOIVKSzVyPUS0MlE{OzJizszN MV;TRW5ITVJ?
COLO-680N MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;EOJU6UUN3ME20OE4{OzlizszN NV\GO5gyW0GQR1XS
Hs-578-T M{nqZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEWwdoZKSzVyPUS1MlAzQTRizszN NEfUWlFUSU6JRWK=
MSTO-211H NHX4OYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnKyTWM2OD12NT65OFgzKM7:TR?= M{XBU3NCVkeHUh?=
EW-1 NV;l[HN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTR3Lkm2PFkh|ryP NHuydVBUSU6JRWK=
SW948 NHLnV4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XGZWlEPTB;NE[uOFQ3OiEQvF2= NWXXbIFMW0GQR1XS
NCI-H460 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHkPVg3UUN3ME20Ok42OjNizszN M3z0[HNCVkeHUh?=
CAS-1 MknzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17rTmlEPTB;NE[uO|cxOSEQvF2= M4rac3NCVkeHUh?=
TGBC11TKB NWHZOm1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XBVGlEPTB;NEeuNVc4PyEQvF2= NW\IXotTW0GQR1XS
HD-MY-Z M1TjZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF25[mJKSzVyPUS4Mlc5PiEQvF2= NG\MUGhUSU6JRWK=
NCI-H226 NUD5dFZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LMTmlEPTB;NEmuO|c5PSEQvF2= NVSxOGQ5W0GQR1XS
PA-1 MnvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXUdWJKSzVyPUS5Mlg{OzVizszN NF;0e2FUSU6JRWK=
LB2518-MEL MkXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLz[ppIUUN3ME20PU45PzJ|IN88US=> NWW1R2FyW0GQR1XS
A101D MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnocWRKSzVyPUS5Mlk1OjVizszN NWOzZ2w4W0GQR1XS
NCI-H2087 M4HmUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTR7Lkm2PFIh|ryP NEft[3hUSU6JRWK=

... Click to View More Cell Line Experimental Data

体内研究 活体研究时按实验对象体重,每千克口服20 mg BIBW2992持续25天,肿瘤产生明显的衰退现象,通过肿瘤切片的免疫组织化学染色观察发现,EGFR和AKT的磷酸化作用收到抑制。因此,正如lapatinib和neratinib, BIBW2992是次代酪氨酸激酶抑制剂,不可逆地抑制人类EGFR2(HER2)和EGFR激酶。BIBW2992不仅能和原代酪氨酸激酶如erlotinib和gefitinib一样有效抑制EGFR突变型,而且还能作用于抗erlotinib和gefitinib的EGFR。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

体外激酶活性实验:

人类EGFR和L858R/T790M双重突变型EGFR 的酪氨酸激酶区域与谷胱甘肽巯基转移酶区域相接,提取酪氨酸激酶区域的方法见补充说明。在有和没有BIBW2992时分别测定酶活。使用杆状病毒系统克隆HER2激酶,用类似提取EGFR激酶域的方法提取HER2激酶域。
细胞实验:

[1]

+ 展开
  • Cell lines: NSCLC细胞
  • Concentrations: 0-10 μM
  • Incubation Time: 1小时
  • Method:

    细胞按1×104密度转移到96孔板上,在无血清培养基上过夜培养,用于EGFR磷酸化实验。第二天添加包含BIBW2992的混合物,培养基在37oC温育1小时。在室温下用100 ng/ml EGF刺激10分钟。细胞用冰冻PBS冲洗,然后每孔用120 μl HEPEX buffer萃取,然后在室温下震荡1小时。每孔中所有2×104细胞都用于HER2磷酸化实验。在涂有链霉亲和素的板上加用封闭液按1:100比例稀释的抗EGFR的生物素和c-erb2/HER2肿瘤蛋白Ab-5-生物素。上述步骤得到的萃取物转移到有抗体包被的孔中,室温下温育1小时。彩色显影的测法见补充说明,吸光度为450纳米。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 雌性无胸腺NMRI-nu/nu鼠
  • Formulation: 0.5%甲基纤维素-0.4% Tween-80
  • Dosages: 20 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
10mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 485.94
化学式

C24H25ClFN5O3

CAS号 439081-18-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02780687 Recruiting Urologic Neoplasms Boehringer Ingelheim June 9 2016 Phase 2
NCT02131259 Completed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim May 7 2014 --
NCT02216617 Completed HNSCC Groupe Oncologie Radiotherapie Tete et Cou August 6 2014 Phase 1
NCT02451553 Recruiting Advanced Malignant Solid Neoplasm|Bile Duct Carcinoma|Recurrent Malignant Solid Neoplasm|Recurrent Pancreatic Carcinoma|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IVA Pancreatic Cancer|Stage IVB Pancreatic Cancer University of Washington|National Cancer Institute (NCI) November 5 2015 Phase 1
NCT02047903 Active not recruiting Carcinoma Non-Small-Cell Lung Boehringer Ingelheim March 5 2014 --
NCT01523587 Completed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim March 5 2012 Phase 3

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • 回答:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFR Signaling Pathway Map

EGFR Inhibitors with Unique Features

相关EGFR产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID