Luminespib (AUY-922, NVP-AUY922)

目录号:S1069 别名: VER-52296

Luminespib (AUY-922, NVP-AUY922) Chemical Structure

Molecular Weight(MW): 465.54

Luminespib (AUY-922, NVP-AUY922)是一种高效的HSP90抑制剂,无细胞试验中作用于HSP90α/βIC50为13 nM /21 nM,对HSP90家族成员GRP94和TRAP-1具有稍弱的作用,与任何小分子HSP90配体均可紧密结合。Phase 2。

规格 价格 库存 购买数量  
RMB 2620.46 现货
RMB 1303.22 现货
RMB 2216.44 现货
RMB 3853.15 现货
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客户使用该产品的3个实验数据:

  • U2OS_exo cells were incubated with AUY922 for 20 h at the indicated concentrations before stimulation with TNFα (30 ng/mL) for 30 min and immunostaining to detect NF-κB (p65). DMSO 1%, cells stimulated by TNFα in the absence of AUY922. Representative pictures used to quantify nuclear and cytoplasmic localization of NF-κB.

    Proc Natl Acad Sci USA, 2014, 111(15): E1528–37 . Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

    J Biol Chem 2013 288(23), 16308-20. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

  • Western blots show the molecular signature of HSP90 inhibition by NVP-AUY922  (ie, induction of HSP72 and depletion of client proteins such as ERBB2, CRAF and CDK4) in BT474 breast cancer cell line. GAPDH was used as loading control.

     

     

    2011 Dr. Swee Sharp and Professor Paul Workman from Cancer Research UK. Luminespib (AUY-922, NVP-AUY922) purchased from Selleck.

产品安全说明书

HSP (e.g. HSP90)抑制剂选择性比较

生物活性

产品描述 Luminespib (AUY-922, NVP-AUY922)是一种高效的HSP90抑制剂,无细胞试验中作用于HSP90α/βIC50为13 nM /21 nM,对HSP90家族成员GRP94和TRAP-1具有稍弱的作用,与任何小分子HSP90配体均可紧密结合。Phase 2。
靶点
HSP90α [1]
(Cell-free assay)
HSP90β [1]
(Cell-free assay)
13 nM 21 nM
体外研究

体外研究时NVP-AUY922抑制多种人类肿瘤细胞系的增殖,GI50平均值为9 nM。NVP-AUY922作用于胃癌细胞时IC50值为2到40 nM。NVP-AUY922作用于BEAS-2B细胞IC50为28.49 nM。使用NVP-AUY922时不影响HSP90的表达,但是提高HSP70的表达。NVP-AUY922增强HSP70与HSP90的结合能力。NVP-AUY922造成p23与HSP复合体的分离。NVP-AUY922能使HSP70结合到HSP90复合体。使用NVP-AUY922,引起酪氨酸激酶受体如VEGFR1, 2, 3和PDGFR-ɑ的表达下降,Akt和p-Akt也下降。另外,NVP-AUY922作用于NCI-N87细胞,引起HER2表达下降。NVP-AUY922提高HSP90与目标蛋白的结合力,然后通过蛋白酶使蛋白降解。NVP-AUY922可以改变多条信号通路而影响细胞生长。此外,使用蛋白酶抑制剂MG132,恢复由于使用NVP-AUY922而降低的胸核苷酸合酶的重新表达。[1]NVP-AUY922提高cleaved caspase-3的表达,及导致HSC-2 细胞凋亡。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CMK NV:2fJBrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILDcZNKSzVyPUCuNFAxOTJ3IN88US=> NYO0bI81W0GQR1XS
MV-4-11 NHrjZnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLvTWM2OD1yLkCwNFU2QCEQvF2= NGX3[nRUSU6JRWK=
NALM-6 MnvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn5OYhJUUN3ME2wMlAxODh2MjFOwG0> MY\TRW5ITVJ?
HOS Mnr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMECxN|gh|ryP NUDJOGppW0GQR1XS
HT-144 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vaVGlEPTB;MD6wNFE2PSEQvF2= MV\TRW5ITVJ?
SW1710 MkDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3qyOWlEPTB;MD6wNFE5PiEQvF2= NXzWWHF4W0GQR1XS
TE-8 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMECyN|ch|ryP Mn\RV2FPT0WU
ES1 NI\FcJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPUVHJTUUN3ME2wMlAxOjZ4IN88US=> MlG1V2FPT0WU
CCF-STTG1 NIfJNZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LmOGlEPTB;MD6wNFI6PyEQvF2= NUTYV5dtW0GQR1XS
PSN1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMECzNVgh|ryP NGPBRnNUSU6JRWK=
CAL-51 MnfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3De2xKSzVyPUCuNFA{OjVizszN NW\vZ49xW0GQR1XS
MCF7 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMECzN|Uh|ryP M2XXSnNCVkeHUh?=
SK-HEP-1 NUD2Onp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnMNFJKSzVyPUCuNFA{OzZizszN MmfSV2FPT0WU
LCLC-103H M2jkT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHGxNFFKSzVyPUCuNFA1OyEQvF2= MnTZV2FPT0WU
HMV-II M2O2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfmfGNzUUN3ME2wMlAxPDR7IN88US=> MknWV2FPT0WU
MES-SA NFjETIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrRSmlKSzVyPUCuNFA1PTJizszN MnfpV2FPT0WU
SK-LMS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnhUZpSUUN3ME2wMlAxPDV6IN88US=> MkPmV2FPT0WU
639-V NGnD[2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEC0PFUh|ryP MYjTRW5ITVJ?
SIG-M5 NGnUUZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fmUWlEPTB;MD6wNFQ5QSEQvF2= Ml20V2FPT0WU
LOUCY MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMEC1NFUh|ryP M2rjdnNCVkeHUh?=
HSC-2 NYPTeItMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfCWGZtUUN3ME2wMlAxPTF6IN88US=> M1qzcnNCVkeHUh?=
EW-13 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;PTWM2OD1yLkCwOVE5KM7:TR?= NWLHW2ZGW0GQR1XS
RT-112 NFL4cFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEiwe3ZKSzVyPUCuNFA2OzVizszN NGjEN|lUSU6JRWK=
NKM-1 M4nSRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPqbHlKSzVyPUCuNFA2PDdizszN M4TI[HNCVkeHUh?=
KYSE-180 NWjkbWt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUSwXJBjUUN3ME2wMlAxPTh4IN88US=> NUDMbINZW0GQR1XS
SW1783 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7ZT3FQUUN3ME2wMlAxPTlzIN88US=> MV;TRW5ITVJ?
A431 M{jndWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2j4SmlEPTB;MD6wNFYxPyEQvF2= NXO1fpllW0GQR1XS
SK-OV-3 NGPQNplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMEC2N{DPxE1? NGSwe|hUSU6JRWK=
RPMI-7951 NXXUXHdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMEC2N|Eh|ryP MmLYV2FPT0WU
Capan-2 NX;JW5E6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEC2N|gh|ryP MnS0V2FPT0WU
HSC-3 Mn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIT2UmxKSzVyPUCuNFA3PDFizszN NUPSSoJlW0GQR1XS
786-0 M1LpcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jkTWlEPTB;MD6wNFY3OyEQvF2= MUHTRW5ITVJ?
Daoy M1jYT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\s[mlEPTB;MD6wNFY6PSEQvF2= MY\TRW5ITVJ?
KGN NYSxUFRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonDTWM2OD1yLkCwO|A{KM7:TR?= MoD5V2FPT0WU
EW-16 MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jPfWlEPTB;MD6wNFc1QSEQvF2= MmXqV2FPT0WU
EW-7 NFf4XHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXrWVduUUN3ME2wMlAxPzV2IN88US=> NHjxXXhUSU6JRWK=
IGROV-1 MnjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzEdIRKSzVyPUCuNFA5OTRizszN MV;TRW5ITVJ?
8505C M2DmNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\kZWlEPTB;MD6wNFgzOSEQvF2= Mnj0V2FPT0WU
RKO NEH5[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnWNohKSzVyPUCuNFA5OjZizszN Mo\4V2FPT0WU
GDM-1 NXvoW206T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3STWM2OD1yLkCwPFQh|ryP Mof4V2FPT0WU
IST-MEL1 MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELxc5lKSzVyPUCuNFA5PTJizszN M1K5THNCVkeHUh?=
RPMI-6666 NXzI[YFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMEC4OVIh|ryP Mnu4V2FPT0WU
SNG-M NGnEOmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7zVWdqUUN3ME2wMlAxQDV4IN88US=> Mn;MV2FPT0WU
KS-1 MnfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH61cXVKSzVyPUCuNFA5PTlizszN MYPTRW5ITVJ?
RXF393 MnPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r1Z2lEPTB;MD6wNFg3KM7:TR?= NYfLVYVLW0GQR1XS
CAL-12T M1LESGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEC5NlIh|ryP MmHLV2FPT0WU
BFTC-905 M1LLfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\ndm5KSzVyPUCuNFA6OzhizszN MYPTRW5ITVJ?
SK-MES-1 NGPUOHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\IT2lEPTB;MD6wNFk1PSEQvF2= NGHneZJUSU6JRWK=
BB30-HNC M3LOUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEC5OVIh|ryP MX3TRW5ITVJ?
AN3-CA NYHaXY5RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEGwNVch|ryP NXzxXlVlW0GQR1XS
EFO-27 Ml;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrtbZhZUUN3ME2wMlAyODF5IN88US=> NFnPUJZUSU6JRWK=
G-401 NWf2b3MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;3TGlEPTB;MD6wNVAzPSEQvF2= MYXTRW5ITVJ?
BPH-1 Ml;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[5TWM2OD1yLkCxNFMh|ryP NIrvdHBUSU6JRWK=
NCI-H727 MmT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV36SFBrUUN3ME2wMlAyODNizszN MVHTRW5ITVJ?
SNU-423 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjUTWM2OD1yLkCxNFU{KM7:TR?= NFHmcIlUSU6JRWK=
KYSE-270 M3SxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEGwOVkh|ryP NG\MTmJUSU6JRWK=
AGS MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoG4TWM2OD1yLkCxNFYyKM7:TR?= M{jOSHNCVkeHUh?=
NCI-H2228 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMEGwOlQh|ryP Mo\LV2FPT0WU
SW954 M2LUOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq5TWM2OD1yLkCxNFcyKM7:TR?= NHLzfJpUSU6JRWK=
769-P NFLUSlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEGwO|Mh|ryP MX7TRW5ITVJ?
BB49-HNC NWrFfWhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPUclliUUN3ME2wMlAyODd5IN88US=> NFLMRZNUSU6JRWK=
IA-LM NYO0ZmhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTWb41yUUN3ME2wMlAyODh4IN88US=> NVT1RndyW0GQR1XS
NB69 NF;ubo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37SbmlEPTB;MD6wNVExOiEQvF2= M3PzOnNCVkeHUh?=
C8166 MnviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEGxNlkh|ryP NGD4SopUSU6JRWK=
NCI-H1299 NVGxTHJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEGxOVQh|ryP M3jSWnNCVkeHUh?=
YKG-1 NGrkdWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jzZWlEPTB;MD6wNVE3KM7:TR?= M3nWS3NCVkeHUh?=
PANC-03-27 NHzkdVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXm4dFZkUUN3ME2wMlAyOTZ{IN88US=> MV\TRW5ITVJ?
YT M3ywPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEGxO|kh|ryP M4L3NHNCVkeHUh?=
CAL-85-1 MmO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DsNmlEPTB;MD6wNVE6OiEQvF2= M16xbHNCVkeHUh?=
GT3TKB MlGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfETWM2OD1yLkCxNlAzKM7:TR?= MYPTRW5ITVJ?
BB65-RCC NW\mdYhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVKyOmh{UUN3ME2wMlAyOjB2IN88US=> NFvJO4RUSU6JRWK=
ES6 NFzid41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEGyOlEh|ryP MVTTRW5ITVJ?
MHH-ES-1 NFLZ[5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMEGyOlMh|ryP NVXtXHlkW0GQR1XS
QIMR-WIL MorpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moe3TWM2OD1yLkCxNlY6KM7:TR?= MoPpV2FPT0WU
SNU-C2B NXLOeo86T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj3emdKSzVyPUCuNFEzPzJizszN NF7HdY1USU6JRWK=
OCI-AML2 M3\lPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TN[2lEPTB;MD6wNVI5OSEQvF2= M4LlSXNCVkeHUh?=
DU-145 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPyTYRIUUN3ME2wMlAyOjlizszN NWnNS|hIW0GQR1XS
SW982 NYridoZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fncmlEPTB;MD6wNVI6OyEQvF2= NX7HPFNrW0GQR1XS
MFH-ino MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMEGyPVMh|ryP NGTqeohUSU6JRWK=
A427 Mo\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEGyPVkh|ryP MVTTRW5ITVJ?
LCLC-97TM1 NVzz[oFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LoOmlEPTB;MD6wNVMh|ryP M4q5UnNCVkeHUh?=
AM-38 MnO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDwb2hKSzVyPUCuNFE{ODJizszN NYiwZXVIW0GQR1XS
K5 NXfYdZA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMEGzNFgh|ryP M2GwUnNCVkeHUh?=
T84 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEGzN|Eh|ryP NVTTPHluW0GQR1XS
TE-15 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPjc5BKSzVyPUCuNFE{OzZizszN M1PH[nNCVkeHUh?=
NCI-H460 NGrX[|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjtXo8{UUN3ME2wMlAyOzN4IN88US=> MVXTRW5ITVJ?
NTERA-S-cl-D1 NH7yRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;YWY1zUUN3ME2wMlAyOzN7IN88US=> MYnTRW5ITVJ?
KYSE-450 MnXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHoWnVKSzVyPUCuNFE{PDlizszN NHPS[IFUSU6JRWK=
H4 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYS4dmRMUUN3ME2wMlAyOzZ4IN88US=> MWXTRW5ITVJ?
LC-2-ad MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnoTWM2OD1yLkCxN|ch|ryP M2\OS3NCVkeHUh?=
GAMG NUnVS3VPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjyPYVKSzVyPUCuNFE{PzFizszN M12zPXNCVkeHUh?=
TK10 MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH1Z5pKSzVyPUCuNFE{QDJizszN MWHTRW5ITVJ?
NCI-H2122 NFvHXGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\id3ozUUN3ME2wMlAyOzh2IN88US=> MWTTRW5ITVJ?
KM12 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELvco9KSzVyPUCuNFE{QTlizszN M3yxPHNCVkeHUh?=
CAL-39 M2jD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HT[GlEPTB;MD6wNVQzKM7:TR?= Moj1V2FPT0WU
RPMI-2650 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEG0N|Ih|ryP MmLiV2FPT0WU
KYSE-510 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm0TWM2OD1yLkCxOFQzKM7:TR?= MWLTRW5ITVJ?
KALS-1 NVfhPYVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TlemlEPTB;MD6wNVQ3PiEQvF2= MXLTRW5ITVJ?
NCI-H1648 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDJ[m1KSzVyPUCuNFE1QTlizszN M4e2TnNCVkeHUh?=
ES4 NXzsPZNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMEG1NFIh|ryP M32zWnNCVkeHUh?=
C-33-A NF:3WJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTXTWM2OD1yLkCxOVA6KM7:TR?= M3O1SXNCVkeHUh?=
MIA-PaCa-2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37QVmlEPTB;MD6wNVUxQSEQvF2= MWfTRW5ITVJ?
Becker M3f1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rR[2lEPTB;MD6wNVUyPCEQvF2= MkPaV2FPT0WU
HOP-62 NGjvOphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIe4TXRKSzVyPUCuNFE2PDJizszN MXPTRW5ITVJ?
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BC-1 MnL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7uXZhKSzVyPUCuNFM{PjdizszN MkPQV2FPT0WU
ES7 M37j[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMEOzO|Qh|ryP NUn3OWw1W0GQR1XS
Daudi M{nncGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMEOzO|Yh|ryP M2HMb3NCVkeHUh?=
RS4-11 NWfQeIZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX31NphPUUN3ME2wMlA{Ozh|IN88US=> NVzCcYo2W0GQR1XS
JiyoyeP-2003 NEXKd3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TPWWlEPTB;MD6wN|M5QCEQvF2= Ml3nV2FPT0WU
BL-70 NFXQTZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfQfpBKSzVyPUCuNFM{QDlizszN NXLCZVFtW0GQR1XS
OS-RC-2 M{DZTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlOwTWM2OD1yLkCzN|k3KM7:TR?= NXnhOJpCW0GQR1XS
SF268 M37HOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzjTWM2OD1yLkCzOFAyKM7:TR?= MoDwV2FPT0WU
BV-173 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkSzTWM2OD1yLkCzOFI3KM7:TR?= MVnTRW5ITVJ?
DMS-273 M1nCZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVO4VWNoUUN3ME2wMlA{PDd7IN88US=> Mmr0V2FPT0WU
22RV1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEO1NFch|ryP M3X4fnNCVkeHUh?=
ES8 NGToZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTuTWM2OD1yLkCzOVM5KM7:TR?= M{G4UHNCVkeHUh?=
KYSE-150 NVjy[2JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3WTWM2OD1yLkCzOlA5KM7:TR?= NIK3NWVUSU6JRWK=
HCC1569 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMEO2NFgh|ryP NXn6epo3W0GQR1XS
NB5 MlHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMEO2NVMh|ryP NYntZmU1W0GQR1XS
G-402 NE\1XG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEO2NVQh|ryP MmjBV2FPT0WU
NCI-H1693 NF7VZXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETRU3JKSzVyPUCuNFM3OTdizszN NVLac|RlW0GQR1XS
LB2241-RCC NVfrNolLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\TOYRKSzVyPUCuNFM3PDJizszN M{nSVHNCVkeHUh?=
KP-4 MnLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIntdndKSzVyPUCuNFM3PjNizszN NIi0W|BUSU6JRWK=
ML-2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDRXZNKSzVyPUCuNFM3PzFizszN MkPBV2FPT0WU
KU812 NFjyRmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr5TWM2OD1yLkCzOlg1KM7:TR?= Mni0V2FPT0WU
LS-411N MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\SdYdKUUN3ME2wMlA{PzNzIN88US=> MlTtV2FPT0WU
OAW-42 NGO0Z2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPxTWM2OD1yLkCzO|Q4KM7:TR?= NILRWZNUSU6JRWK=
HCC38 Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\jXGRKSzVyPUCuNFM4PzFizszN NEHxSpBUSU6JRWK=
Ca-Ski M1ruWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfQTWM2OD1yLkCzO|g1KM7:TR?= M3zKPXNCVkeHUh?=
Calu-3 M1:zOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3M[5JJUUN3ME2wMlA{Pzh7IN88US=> NHzGOoNUSU6JRWK=
KYSE-70 MmfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEO4NVIh|ryP NU\2XVdsW0GQR1XS
D-392MG MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMEO4OFIh|ryP MUnTRW5ITVJ?
OVCAR-4 NIryO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3sZYNKSzVyPUCuNFM5PThizszN NFvWfppUSU6JRWK=
Detroit562 NIrWU|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEO4O|Ih|ryP M3HVe3NCVkeHUh?=
HEL MoS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\1ZlBKSzVyPUCuNFM5QTFizszN M4TCXXNCVkeHUh?=
MONO-MAC-6 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELHc|dKSzVyPUCuNFM5QTNizszN M1jycXNCVkeHUh?=
LoVo MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y2eWlEPTB;MD6wN|k{OyEQvF2= Ml7pV2FPT0WU
U-2-OS M13VW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvsfZJKSzVyPUCuNFM6OzVizszN NV7qVXRuW0GQR1XS
A172 M332eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW5TWM2OD1yLkCzPVUh|ryP MVHTRW5ITVJ?
OCUB-M M1fiNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLmW3ZTUUN3ME2wMlA{QTZzIN88US=> NEftVIpUSU6JRWK=
SW48 M{PLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfKdVJIUUN3ME2wMlA1ODNzIN88US=> MnfqV2FPT0WU
HC-1 M1TPXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4KzZ2lEPTB;MD6wOFA3QSEQvF2= MUXTRW5ITVJ?
KOSC-2 NF:3OHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMESxNUDPxE1? NV7Zdlh1W0GQR1XS
HDLM-2 NULvZ44{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmftTWM2OD1yLkC0NVE1KM7:TR?= NUP4W4pSW0GQR1XS
CTV-1 NFm4fHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHW5S|BKSzVyPUCuNFQyOTZizszN NXLiXGNKW0GQR1XS
SH-4 NXHzRmE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMESxOFEh|ryP NYDoO5k3W0GQR1XS
SW756 NGnuTmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK0Upd4UUN3ME2wMlA1OTV5IN88US=> NFv2b2RUSU6JRWK=
GCT NELlbI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMESxOlEh|ryP M3jPdXNCVkeHUh?=
CHL-1 M2XZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnxTllmUUN3ME2wMlA1OTZ7IN88US=> NEXOb|VUSU6JRWK=
LAMA-84 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLnTWM2OD1yLkC0NVcyKM7:TR?= NVrhcZA2W0GQR1XS
LS-1034 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDyTWM2OD1yLkC0NVkyKM7:TR?= NVPBVopOW0GQR1XS
NCI-H358 Mnv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPxTWM2OD1yLkC0NlEzKM7:TR?= Mk\kV2FPT0WU
NB13 M3nwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMESyNlch|ryP MnTjV2FPT0WU
TE-9 Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DK[2lEPTB;MD6wOFI{PyEQvF2= MkfsV2FPT0WU
OE33 NFLWN5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr6TWM2OD1yLkC0NlQyKM7:TR?= MY\TRW5ITVJ?
CAL-120 NHfHZ3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\mTWM2OD1yLkC0NlQyKM7:TR?= NYi3TFFNW0GQR1XS
DJM-1 NYH3ZnJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TMTWlEPTB;MD6wOFI4OiEQvF2= NITOfJZUSU6JRWK=
SK-MEL-24 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Xt[WlEPTB;MD6wOFI5OyEQvF2= NWrNRlFDW0GQR1XS
VA-ES-BJ NHzSZopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnmxTWM2OD1yLkC0NlkzKM7:TR?= MnGyV2FPT0WU
MMAC-SF M4frR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;MZVFKSzVyPUCuNFQzQTdizszN MXvTRW5ITVJ?
MZ7-mel MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLSTWM2OD1yLkC0N|Mh|ryP M{DBXXNCVkeHUh?=
BxPC-3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\iUGkxUUN3ME2wMlA1OzRzIN88US=> MoLEV2FPT0WU
HT-29 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMESzOVch|ryP NWfRU2hSW0GQR1XS
SK-MEL-30 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrDOY1nUUN3ME2wMlA1OzZ{IN88US=> M2PhbXNCVkeHUh?=
CAL-33 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q3N2lEPTB;MD6wOFM4PSEQvF2= M1K1ZnNCVkeHUh?=
COLO-680N NHvjXHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M12wWmlEPTB;MD6wOFQxPyEQvF2= MWPTRW5ITVJ?
NH-12 MnzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T6[mlEPTB;MD6wOFQ1KM7:TR?= NIToNXBUSU6JRWK=
HCC1937 MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr6PVNPUUN3ME2wMlA1PDV4IN88US=> MojhV2FPT0WU
IMR-5 M1P5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TwPGlEPTB;MD6wOFQ6KM7:TR?= M1\PcnNCVkeHUh?=
MC-CAR M2XzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HiNWlEPTB;MD6wOFU3QSEQvF2= NF7DephUSU6JRWK=
NCI-H747 M{fFPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMES1O{DPxE1? MWfTRW5ITVJ?
NCI-H1792 NVz2OJZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDCTWM2OD1yLkC0OVgyKM7:TR?= MVXTRW5ITVJ?
SW13 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TET2lEPTB;MD6wOFU6KM7:TR?= M3m1NHNCVkeHUh?=
MLMA NVjBVYJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nN[2lEPTB;MD6wOFYxQSEQvF2= NIjOUXlUSU6JRWK=
U251 Mn3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e1V2lEPTB;MD6wOFc3OyEQvF2= Ml7yV2FPT0WU
U031 NXvy[JhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7le3dKSzVyPUCuNFQ4PzFizszN NXLhdHh6W0GQR1XS
ME-180 M1y5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3GN5BFUUN3ME2wMlA1Pzh{IN88US=> M1TnUnNCVkeHUh?=
SK-MEL-3 NHv6boJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPCPFBEUUN3ME2wMlA1QDB{IN88US=> MmLQV2FPT0WU
MOLT-4 M4XYTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMES4NFMh|ryP M1;2NnNCVkeHUh?=
PF-382 NUDGT3NjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET6eVVKSzVyPUCuNFQ5OjZizszN NUXMT4xNW0GQR1XS
NUGC-3 M3vYT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLUO3FbUUN3ME2wMlA1QDJ5IN88US=> MXvTRW5ITVJ?
NCI-H1417 M{nnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkK2TWM2OD1yLkC0PFkh|ryP NV\NWG04W0GQR1XS
COLO-205 M2f0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzrNphPUUN3ME2wMlA1QTF7IN88US=> MmTjV2FPT0WU
TE-441-T NYm0OXhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3sTGtzUUN3ME2wMlA1QTNizszN M1O4N3NCVkeHUh?=
MKN1 NGDEVItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMES5N{DPxE1? MYTTRW5ITVJ?
UM-UC-3 NFP6[XRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnSXlBKSzVyPUCuNFQ6PSEQvF2= MU\TRW5ITVJ?
SF126 M2XqeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XiWGlEPTB;MD6wOVAyKM7:TR?= NIPjWYxUSU6JRWK=
LB1047-RCC MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnLTWM2OD1yLkC1NFMyKM7:TR?= MkTiV2FPT0WU
A253 M2HOTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEWwOVIh|ryP NUXoVJZSW0GQR1XS
NCI-H1963 NWDqe5NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nEVWlEPTB;MD6wOVE4PiEQvF2= NInCTYlUSU6JRWK=
VM-CUB-1 M3PjTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3QTWM2OD1yLkC1N|EyKM7:TR?= MnXsV2FPT0WU
T-24 NFH4dmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHncItKSzVyPUCuNFU{QDRizszN MnfIV2FPT0WU
K-562 NHW1UnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDKepR5UUN3ME2wMlA2Ozh5IN88US=> M1TWOHNCVkeHUh?=
ARH-77 M3\MTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEWzPVUh|ryP NH7OR2NUSU6JRWK=
CA46 M1HFWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEW0N{DPxE1? MknQV2FPT0WU
HCC70 MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;he4xIUUN3ME2wMlA2PDV{IN88US=> MUTTRW5ITVJ?
ST486 NVXs[lAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX2zOnlnUUN3ME2wMlA2PTJ3IN88US=> Mlq2V2FPT0WU
COLO-741 NXzZNXhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTnO5M1UUN3ME2wMlA2PTNzIN88US=> MWXTRW5ITVJ?
SK-PN-DW Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i4fWlEPTB;MD6wOVU5QCEQvF2= Mn3TV2FPT0WU
BL-41 NXnKNJV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTGU5dKSzVyPUCuNFU2QTZizszN NFjiTVNUSU6JRWK=
D-263MG MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\CbmlEPTB;MD6wOVY5OyEQvF2= M{O1[XNCVkeHUh?=
KE-37 M{naV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\sNXZqUUN3ME2wMlA2Pjh|IN88US=> NHP3fnBUSU6JRWK=
LU-134-A MknnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMEW3NVUh|ryP NG[4c|hUSU6JRWK=
HCC2157 M2DRbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW1eohKSzVyPUCuNFU4OzNizszN MV\TRW5ITVJ?
GAK NE\kUZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;VbGlEPTB;MD6wOVc{PCEQvF2= NY\tN5Z{W0GQR1XS
IST-SL2 MnnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEW3OFMh|ryP NUP2VI81W0GQR1XS
KMOE-2 NHToTnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nHS2lEPTB;MD6wOVc1QSEQvF2= MkLFV2FPT0WU
SW1573 NFPNRYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\kb3JSUUN3ME2wMlA2QDB{IN88US=> Ml\VV2FPT0WU
SCC-9 NWHKcmZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f4S2lEPTB;MD6wOVg4KM7:TR?= MkfOV2FPT0WU
MDA-MB-361 MoHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\HUpBKSzVyPUCuNFU5PzJizszN MVzTRW5ITVJ?
BHT-101 NGLrPFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3SW4JKSzVyPUCuNFU5PzZizszN NVHoUXZlW0GQR1XS
NCI-H1770 M4P4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\wb2lEPTB;MD6wOVg4QSEQvF2= NYXtcoVmW0GQR1XS
UACC-893 MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHr2OpVKSzVyPUCuNFU5QTZizszN NUfxVGtOW0GQR1XS
NCI-H226 MmL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W1[mlEPTB;MD6wOVk5QCEQvF2= NYHGcJhEW0GQR1XS
HLE M{XCZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILobXZKSzVyPUCuNFYxQDJizszN M{[1eHNCVkeHUh?=
NCI-H1703 NGjF[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwME[xO|gh|ryP Mmf5V2FPT0WU
KURAMOCHI M1zXV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwME[xPFkh|ryP MX7TRW5ITVJ?
RH-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13TO2lEPTB;MD6wOlI{KM7:TR?= M{nnRnNCVkeHUh?=
DSH1 NVnmNI5rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3O0TmlEPTB;MD6wOlI4KM7:TR?= NV2x[JpNW0GQR1XS
CAMA-1 NFnF[INIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LkUWlEPTB;MD6wOlMxOyEQvF2= Ml;SV2FPT0WU
NCI-H1437 NVKzbY5{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DTSGlEPTB;MD6wOlMzQCEQvF2= MUTTRW5ITVJ?
HuP-T4 NYLZOJRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjxbGFFUUN3ME2wMlA3PTh4IN88US=> MXTTRW5ITVJ?
HCT-15 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU[5S5FxUUN3ME2wMlA3PTl5IN88US=> NVvaWoY3W0GQR1XS
NCCIT NFzuNI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwME[2NFQh|ryP M4P6d3NCVkeHUh?=
BOKU NV;3N4xUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTxSIs5UUN3ME2wMlA3Pjd2IN88US=> MYLTRW5ITVJ?
FADU MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zkNWlEPTB;MD6wOlc1PSEQvF2= NXW4bW41W0GQR1XS
SUP-T1 NH;xWplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XBTmlEPTB;MD6wOlc3KM7:TR?= M3PEOnNCVkeHUh?=
L-363 M1:4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi3Z21NUUN3ME2wMlA3QTBzIN88US=> MVHTRW5ITVJ?
KNS-81-FD MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\NXFVKSzVyPUCuNFY6OThizszN MWDTRW5ITVJ?
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TALL-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j2bmlEPTB;MT6yOVE3PSEQvF2= Ml65V2FPT0WU
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NCI-H1581 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTFwM{W2PFch|ryP MV7TRW5ITVJ?
NCI-H748 M3vFe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLTTWM2OD1zLkO1O|M5KM7:TR?= M1[0SXNCVkeHUh?=
HCC1187 M1\0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXoOllvUUN3ME2xMlU2PTJ{IN88US=> NVvCPXJtW0GQR1XS
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HuO-3N1 NVnYZ3lmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nPRWlEPTB;MT64N|QyOiEQvF2= MkTYV2FPT0WU
NCI-H1793 NGfV[ldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HyfWlEPTB;MT64O|U6OyEQvF2= MkLoV2FPT0WU
Caov-3 MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3ITWM2OD1{LkCwOlI2KM7:TR?= M3LCWnNCVkeHUh?=
JAR MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\jXZR2UUN3ME2yMlA4QTJizszN M2\sdnNCVkeHUh?=
SK-MEL-28 NUjMUo57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTZTHdpUUN3ME2yMlE5ODl6IN88US=> MVrTRW5ITVJ?
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Mewo MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XhdWlEPTB;Mj6yNlI3PSEQvF2= NEHKXndUSU6JRWK=
NCI-H720 NXfob|F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXj3WFc4UUN3ME2yMlI3PTh3IN88US=> M4izdXNCVkeHUh?=
CAL-54 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWiyR4ZrUUN3ME2yMlI3Pzl3IN88US=> NIW0SFhUSU6JRWK=
MC116 NX;SU|ZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4WzXmlEPTB;Mj6zOlM6PyEQvF2= M3\P[3NCVkeHUh?=
DG-75 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJwNEi1O|Yh|ryP MVrTRW5ITVJ?
HCC1143 M3LGTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\YW2oyUUN3ME2yMlUxPjV6IN88US=> M3vKNHNCVkeHUh?=
FTC-133 M1HTdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlOzTWM2OD1{LkWzOlg6KM7:TR?= NGjSSVdUSU6JRWK=
AsPC-1 M13iNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJwNUO5Nlkh|ryP MX3TRW5ITVJ?
NCI-H889 M2TQS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHsTWM2OD1{LkW2O|A3KM7:TR?= NH;HcmVUSU6JRWK=
HT55 MkjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTJwNkKwNVkh|ryP MmruV2FPT0WU
UMC-11 NE\GcXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHhTWM2OD1{Lke4O|E2KM7:TR?= Mn;WV2FPT0WU
P12-ICHIKAWA NHTyVopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\YZZBKSzVyPUKuPFIxPDZizszN NY\zS3Y1W0GQR1XS
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D-283MED NHHNNGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rwUWlEPTB;Mz6xPFk{PyEQvF2= MoPYV2FPT0WU
COLO-800 Mkm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTNwM{O4PVch|ryP Mn3UV2FPT0WU
MFM-223 M2TpO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTNwM{[wPVch|ryP MUnTRW5ITVJ?
TE-5 NGTIV49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTRwNU[xOFch|ryP NVPUZnlxW0GQR1XS
NCI-H209 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;MTWM2OD12Lke4OVczKM7:TR?= MlfaV2FPT0WU
SiHa MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTRwOUWyNFMh|ryP MVXTRW5ITVJ?
NCI-H1395 M1LucGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTVwMUC2N|Mh|ryP M{fZeHNCVkeHUh?=
A498 M{XpO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;iXGlEPTB;NT6yNVI2OSEQvF2= NEPv[ZpUSU6JRWK=
ES5 M3nKPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvj[45pUUN3ME21MlYyOTd6IN88US=> NXywT2hbW0GQR1XS
MDA-MB-157 NXXsW2tVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzacpFsUUN3ME21MlY3PDR|IN88US=> NWT6[3hPW0GQR1XS
NCI-H1623 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7ySIpGUUN3ME21Mlg{PTV4IN88US=> MX3TRW5ITVJ?
RPMI-8866 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofrTWM2OD13Lki0O|kzKM7:TR?= NFLSSllUSU6JRWK=
LC-1F MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTKTWM2OD14LkC5NlkyKM7:TR?= NFPBfW9USU6JRWK=
TCCSUP NV25TlRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnpfYlKSzVyPU[uOlA{PDlizszN M{e4SHNCVkeHUh?=
TT NWG5fHAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2njdGlEPTB;OD6zN|AxQSEQvF2= NXTz[otiW0GQR1XS
NCI-H1838 NWHFOGdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRThwNUG3N|Eh|ryP M2\KNnNCVkeHUh?=
NCI-H322M NI[1bJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[y[mlEPTB;OT6xOlI5OSEQvF2= MlXlV2FPT0WU
NCI-H187 NX36dXpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTlwNUG4N|Uh|ryP M2L1NHNCVkeHUh?=
SBC-1 M3[1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDLTWM2OD17LkmzOlU3KM7:TR?= NV;KbHk{W0GQR1XS
SCC-3 M3ro[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfMeWJKSzVyPUGwMlU3PzlizszN NILUOZlUSU6JRWK=
SW948 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHX1c3NKSzVyPUGwMlc2OTFizszN NHXVUGJUSU6JRWK=
CPC-N NUjS[oZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXkcZNKSzVyPUGxMlAxPyEQvF2= M2D3dnNCVkeHUh?=
TGBC24TKB NGfFTnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHry[IlKSzVyPUGzMlUzQSEQvF2= NVnRXZc3W0GQR1XS
NCI-H2452 NE\SfmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTF2LkezJO69VQ>? NIO5d29USU6JRWK=
Hs-578-T NV;6flZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2O2T2lEPTB;MUiuOVc2QSEQvF2= NXPEZWpwW0GQR1XS
DV-90 NVnrSJZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIi5TI1KSzVyPUG4Mlk6PDVizszN M1z1W3NCVkeHUh?=
NCI-H1563 M1XaZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXiwS405UUN3ME2xPU44QDh6IN88US=> MUXTRW5ITVJ?
SW780 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPBTWM2OD1{MT6xN|E5KM7:TR?= MnnxV2FPT0WU
NCI-H345 NWfZcI1HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJzLki3O|kh|ryP M1TqTnNCVkeHUh?=
LB771-HNC MoHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fm[2lEPTB;MkKuOFgyOyEQvF2= M2LPcHNCVkeHUh?=
RT4 MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTJ|LkOyPFIh|ryP M{fsb3NCVkeHUh?=
NCI-H82 M{HCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LBRWlEPTB;MkOuOVUzPiEQvF2= MUjTRW5ITVJ?
NCI-H524 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;jbmVoUUN3ME2yOE4{QDF{IN88US=> NGfDfXRUSU6JRWK=
SNU-C1 NEnuXZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLRZ3ViUUN3ME2yOE46OTB3IN88US=> NFrDSGpUSU6JRWK=
NCI-SNU-16 NUiyR5pqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjPcGxuUUN3ME20PE4{OTR{IN88US=> NW[2OVN4W0GQR1XS

... Click to View More Cell Line Experimental Data

体内研究 使用NVP-AUY922可引起强的抗癌反应,可抑制HSC-2移植瘤模型中p-Akt和VEGF的表达。[2] 在12种实验肿瘤中观察到5种肿瘤衰退。体重降低<5%,且与HSP90相关的生物标签明显改变。BT474中, ERBB2完全缺失,ERα耗尽,且CDK4和磷酸化ERK1/2降低。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[3]
+ 展开

激酶实验:

NVP-AUY922溶解在DMSO中,浓度为10mM。通过作用于HSP90α, HSP90β, GRP94, TRAP-1, HSP72,和拓扑异构酶II评估NVP-AUY922的活性。
细胞实验:[1]
+ 展开
  • Cell lines: 人类胃癌细胞系NCI-N87
  • Concentrations: 1 μM
  • Incubation Time: 3天
  • Method: 人类胃癌细胞NCI-N87按5-7×103密度接种在96孔板中,每孔接种50ul,在37oC下温育24小时,然后用NVP-AUY922处理1到3天。实验处理后,使用MTT实验测细胞活力,用酶标仪分析。
    (Only for Reference)
动物实验:[3]
+ 展开
  • Animal Models: 携带WM266.4人类黑色素移植瘤的雌性NCr无胸腺鼠
  • Formulation: 溶于在DMSO中,用无菌盐水/Tween-20稀释。
  • Dosages: 50 mg/kg
  • Administration: 静脉注射或腹腔注射
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 93 mg/mL warmed (199.76 mM)
Ethanol 31 mg/mL (66.58 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
1% DMSO+30% polyethylene glycol+1% Tween 80
30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 465.54
化学式

C26H31N3O5

CAS号 747412-49-3
稳定性 powder
别名 VER-52296

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01784640 Active, not recruiting Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) January 2014 Phase 1
NCT01922583 Active, not recruiting Non-small Cell Lung Cancer (NSCLC) National Taiwan University Hospital January 2014 Phase 2
NCT01854034 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital July 2013 Phase 2
NCT01772797 Completed Anaplastic Lymphoma Kinase (ALK)|Non-small Cell Lung Cancer Novartis Pharmaceuticals|Novartis June 2013 Phase 1
NCT01752400 Active, not recruiting Non Small Cell Lung Cancer Massachusetts General Hospital January 2013 Phase 2
NCT01613950 Completed Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein Novartis Pharmaceuticals|Novartis December 2012 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

HSP (e.g. HSP90) Signaling Pathway Map

HSP (e.g. HSP90) Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID