Dabrafenib (GSK2118436)

目录号:S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436)是一种突变型BRAFV600特异性抑制剂,无细胞试验中IC50为0.8 nM,作用于B-Raf(wt)和c-Raf效果分别低4和6倍。

规格 价格 库存 购买数量  
RMB 1481.39 现货
RMB 733.64 现货
RMB 1056.75 现货
RMB 1394.46 现货
RMB 2235.84 现货
RMB 3261.37 现货
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客户使用该产品的5个实验数据:

  • A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

    Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

  • The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

    Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

  • Western blot analysis of p-Erk and total ERK in A375 melanoma cell line after treatment with different doses of Dabrafenib for 48 hours (A). p-ERK signal was normalized with total ERK signal (B), SD and means of the normalized p-ERK values were reported.

    PLoS One, 2016, 11(3):e0152104. Dabrafenib (GSK2118436) purchased from Selleck.

产品安全说明书

Raf抑制剂选择性比较

生物活性

产品描述 Dabrafenib (GSK2118436)是一种突变型BRAFV600特异性抑制剂,无细胞试验中IC50为0.8 nM,作用于B-Raf(wt)和c-Raf效果分别低4和6倍。
靶点
B-Raf (V600E) [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
C-Raf [1]
(Cell-free assay)
0.8 nM 3.2 nM 5.0 nM
体外研究

Dabrafenib对Raf激酶具有选择性,对B-Raf的活性比其它测试过的91%的激酶高400倍。 Dabrafenib抑制B-RafV600E激酶,导致ERK磷酸化降低和抑制细胞的增值,在特异性编码突变的B-RafV600E的癌细胞中细胞停滞在G1期。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MlXST4lv[XOnIFHzd4F6 MVTJcohq[mm2aX;uJI9nKE5vdHXycYlv[WxiSHnzJJRi\2enZDDCMXJi\iCYNkCwSUBufXSjboSg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIHnud4VkfCClZXzsd{Bkdy2neIDy[ZN{cW6pIFPER|M4KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJIJqd3SrbonsZZRm\C2PRVugdJJwfGWrbjDwbI9{eGixconsZZRqd25iYomgRYxxcGGVY4Ll[Y4h[XO|YYmge4l1cCCLQ{WwJI9nKDBwMECwO{DPxE1? NXu5[JhQOjR7MEC2O|M>
SK-MEL-28 MYHLbY5ie2ViQYPzZZk> NIraUVkyKGh? MV;Jcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCVSz3NSWwuOjhiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP Mmj4NlQ6ODB4N{O=
HepG2 NGntVodMcW6jc3WgRZN{[Xl? NWnBfJV1UW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSgbY4hcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP NGnRTpEzPDlyME[3Ny=>
COLO205 NG\Bc2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\DUXNvUW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPNlA2KGOnbHygdJJwdGmoZYLheIlwdiC5aYToJGlEPTBib3[gNE4xODdizszN MYqyOFkxODZ5Mx?=
HepG2 MkLBSpVv[3Srb36gRZN{[Xl? MUm0OUBucW5? M1HZPWROW09? NVzXS4cxUW6qaXLpeIlwdiCxZjDBcIs2KGmwIGTHSk1j\XSjLYP0bY12dGG2ZXSgbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iU33h[FIheGixc4Doc5J6dGG2aX;uJJRz\WG2ZXSg[o9zKDR3IH3pcpMheHKrb4KgeI8hXEeILXLleIEhe3SrbYXsZZRqd25ibXXhd5Vz\WRiYX\0[ZIhPjBibXnud{BjgSCxZInzd4V6KGKub4Sgd4Nidm6ncjDhcoFtgXOrczD3bZRpKEmFNUCgc4YhOy55IN88US=> NVuyOXZqOjR7MEC2O|M>
HFF NI\ITHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPyNVAh|ryP NXjSOZZvPzJiaB?= NGPoV|JFVVOR MorsTY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJI9nKGi3bXHuJGhHTiClZXzsd{Bp[XKkb4Lpcochf2muZDD0fZBmKEJvUnHmJJdqfGhiSVO1NEBw\iB|IN88US=> MXmyN|g1PDB|OB?=
SK-MEL-28 MkTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjD[YpNOTBizszN NYPG[3RNPzJiaB?= NVr3VYFxTE2VTx?= MlLPTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKFONLV3FUE0zQCClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODR|IN88US=> MlnGNlM5PDRyM{i=
A375P-F11 M{HocWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvqPJprOTBizszN M2PrR|czKGh? M3nZcGROW09? M3jlS2lvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62LXTybZZmdiCDM{e1VE1HOTFiY3XscEBxem:uaX\ldoF1cW:wIIfpeIghUUN3MDDv[kAxNjB5MTFOwG0> Mk[1NlM5PDRyM{i=
MALME-3M M1TZW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUWxNEDPxE1? NUTNVHhVPzJiaB?= MWnEUXNQ M3XC[mlEPTB;MTDuUS=> NUXD[lRLOjN6NESwN|g>
UACC-62 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnHN5IyOCEQvF2= NYn2[Gs{PzJiaB?= MnrXSG1UVw>? MVLJR|UxRTFibl2= NICyU5YzOzh2NECzPC=>
C32TG NIX3eXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYr6UZpLOTBizszN MYm3NkBp Mmf5SG1UVw>? M1O4TGlEPTB;MTDuUS=> M{DCVVI{QDR2MEO4
SK-MEL-1 M4joW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XTOFExKM7:TR?= NWPJPW5KPzJiaB?= NEHtOmpFVVOR MVrJR|UxRTJibl2= MmXPNlM5PDRyM{i=
M14 NF\iToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;5WWQyOCEQvF2= MmnOO|IhcA>? M13LOGROW09? MlzrTWM2OD1{IH7N M4npS|I{QDR2MEO4
SK-MEL-28 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX6xNEDPxE1? NH7XO|Q4OiCq MWXEUXNQ MYXJR|UxRTNibl2= M1ezWlI{QDR2MEO4
A375 NFXaTHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Pkd|ExKM7:TR?= MX[3NkBp Ml2xSG1UVw>? M{XFUGlEPTB;NDDuUS=> NYrCdHVCOjN6NESwN|g>
DU-4475 M2PnW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPWNVAh|ryP NHLlUGY4OiCq MoP0SG1UVw>? NWTFN4FZUUN3ME21JI5O MXyyN|g1PDB|OB?=
UACC-257 NWXmVFFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[xNEDPxE1? NF3zSlg4OiCq NFTqW|hFVVOR MWLJR|UxRTZibl2= MnTGNlM5PDRyM{i=
Colo 205 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXqxNEDPxE1? NGDONmg4OiCq MWXEUXNQ NWTkenA6UUN3ME23JI5O NHn1UXozOzh2NECzPC=>
SK-MEL-3 NIjMOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e0PFExKM7:TR?= NUCxSXlZPzJiaB?= Mn\4SG1UVw>? M1;PT2lEPTB;NzDuUS=> MXyyN|g1PDB|OB?=
SH-4 NXTuZnM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYixNEDPxE1? MWK3NkBp NI\zXpdFVVOR NVHCcYZtUUN3ME24JI5O MVSyN|g1PDB|OB?=
A101D MkjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X6XVExKM7:TR?= MoDBO|IhcA>? MWrEUXNQ NFrETXJKSzVyPUmgcm0> NGjrNWUzOzh2NECzPC=>
ES-2 NWO5e|FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfZUlFMOTBizszN MWC3NkBp MWXEUXNQ MoG5TWM2OD13MzDuUS=> MnSxNlM5PDRyM{i=
HT-29 MlqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHLZnkyOCEQvF2= NXHPWnhoPzJiaB?= MlLLSG1UVw>? NYroUWZIUUN3ME22OkBvVQ>? NYG3RpB7OjN6NESwN|g>
SW1417 NFvXWZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHHXm9ZOTBizszN NHTN[IY4OiCq MYLEUXNQ Mn61TWM2OD1zNUigcm0> MYmyN|g1PDB|OB?=
SW872 NVvsNmk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPyNVAh|ryP M3PBUFczKGh? MlrXSG1UVw>? MmTyTWM2OD1|N{egcm0> MmLQNlM5PDRyM{i=
RKO M174SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjXc5YyOCEQvF2= MoftO|IhcA>? NVfJPWRFTE2VTx?= NVSzOJcxUUN3ME2yMlUzOiEQvF2= NGC1fIszOzh2NECzPC=>
A673 NGHzU|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXRN49YOTBizszN MknDO|IhcA>? MlrJSG1UVw>? MUDJR|UxRTFyIN88US=> Mo\NNlM5PDRyM{i=
GCT NXvXSHNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjoemoyOCEQvF2= NIr2Vmc4OiCq NIe1cFdFVVOR Ml73TWM2OD1zMDFOwG0> NEnFTYgzOzh2NECzPC=>
WM-115 M3G4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\lU|ExKM7:TR?= MlTuO|IhcA>? NGfuOIpFVVOR MX;JR|UxRTVibl2= MYqyN|g1PDB|OB?=
YUMAC NFHKNZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX1SVYyOCEQvF2= M4jkO|czKGh? M3HnXGROW09? NEHOblZKSzVyPUWgcm0> NUTWcGkxOjN6NESwN|g>
OV-90 M3XO[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHr5fFkyOCEQvF2= NVjnVGhNPzJiaB?= M13Zd2ROW09? NHXHSYtKSzVyPUK5JI5O NULTZWlxOjN6NESwN|g>
NCI-H508 M{fL[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\yNVAh|ryP M1LmcVczKGh? M1L3UGROW09? MXfJR|UxRTFyIN88US=> M{P5[FI{QDR2MEO4
MDA-MB-231 MkXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYWxNEDPxE1? NVjoRVNQPzJiaB?= NIDpZ|BFVVOR MnHhTWM2OD1zMDFOwG0> MnLVNlM5PDRyM{i=
SW756 M3vGU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:xTFExKM7:TR?= M2PhVVczKGh? NYq4b2RuTE2VTx?= NUTHVplWUUN3ME2xNEDPxE1? NWHrXpp7OjN6NESwN|g>
SW-837 MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;XdZZJOTBizszN MYO3NkBp NHHnUndFVVOR MYjJR|UxRTFyIN88US=> NWfpSXEyOjN6NESwN|g>
UMUC-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDHelQ6OTBizszN NHTs[XU4OiCq NYS3V4ZQTE2VTx?= NHTGfnRKSzVyPUGwJO69VQ>? NGWyfo4zOzh2NECzPC=>
LS-174T M1G2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWGxNEDPxE1? NWPubVExPzJiaB?= M1;yZWROW09? M4qwbGlEPTB;MUCg{txO NEHZUJUzOzh2NECzPC=>
A549 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXixNEDPxE1? NGLPe2o4OiCq NYjON2liTE2VTx?= MmG1TWM2OD1zMDFOwG0> M4rxTFI{QDR2MEO4
SHP-77 M4ryS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfENVAh|ryP MXG3NkBp NFPzWpZFVVOR MWXJR|UxRTFyIN88US=> M13wS|I{QDR2MEO4
SW480 Mmf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\ZPZcyOCEQvF2= NIXxOmw4OiCq NVHyOIR2TE2VTx?= NE\RW2pKSzVyPUGwJO69VQ>? M4THc|I{QDR2MEO4
DLD-1 M1XoSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnqN4IyOCEQvF2= M1LRbVczKGh? NG\Hbo1FVVOR Mn3ITWM2OD1zMDFOwG0> M17HeVI{QDR2MEO4
HCT-116 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP2SpAyOCEQvF2= MUK3NkBp NVHicHRKTE2VTx?= MknCTWM2OD1zMDFOwG0> MU[yN|g1PDB|OB?=
NCI-H747 NFL2SIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnJNVAh|ryP MoLDO|IhcA>? M4C3cWROW09? M4TZemlEPTB;MUCg{txO MoHHNlM5PDRyM{i=
T-84 NHrvdJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfzSmUyOCEQvF2= NVLrfVc3PzJiaB?= Mm\XSG1UVw>? MVrJR|UxRTFyIN88US=> MojBNlM5PDRyM{i=
NCI-H460 NFzyV5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH76cm0yOCEQvF2= Mm\wO|IhcA>? MWfEUXNQ NHnpTZZKSzVyPUGwJO69VQ>? NEXFSYczOzh2NECzPC=>
Calu-6 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV[xNEDPxE1? NV7nSI5TPzJiaB?= NGS5ZWpFVVOR MWnJR|UxRTFyIN88US=> NIK1coUzOzh2NECzPC=>
HCC-2998 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zCcVExKM7:TR?= NIrxUFk4OiCq M2TkXGROW09? Mo[0TWM2OD1zMDFOwG0> M1q4elI{QDR2MEO4
LS1034 M2fkfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYGxNEDPxE1? M3fUZlczKGh? MkfuSG1UVw>? NVnPT4F6UUN3ME2xNEDPxE1? Ml\xNlM5PDRyM{i=
CHP-212 M3jnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3qwR|ExKM7:TR?= NIXJdZA4OiCq Mm\NSG1UVw>? NIT4Zm9KSzVyPUGwJO69VQ>? MVeyN|g1PDB|OB?=
SK-N-AS M3nMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHaNVAh|ryP M2CwTlczKGh? M2ruOmROW09? NVK3bZJ2UUN3ME2xNEDPxE1? NVfQVGZ7OjN6NESwN|g>
BFTC-905 MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTWNVAh|ryP MX63NkBp MmjiSG1UVw>? NF3KV3RKSzVyPUGwJO69VQ>? NWrndpVJOjN6NESwN|g>
HuT78 MkHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVu2N3Y6OTBizszN MlnDO|IhcA>? M4DC[2ROW09? NYrNflJtUUN3ME21NkBvVQ>? NY\kelZoOjN6NESwN|g>
RPMI-8226 M3jSfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\NTVExKM7:TR?= NFThV4M4OiCq NUfHV5U3TE2VTx?= M{TueGlEPTB;Mk[zJI5O M3vHTlI{QDR2MEO4
BC-3 NH61bWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXJ[4wyOCEQvF2= NVvPOmtWPzJiaB?= MWPEUXNQ NVnQU4V6UUN3ME2yO|chdk1? NVHGfFh{OjN6NESwN|g>
ACHN MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nIV|ExKM7:TR?= NEC5XHk4OiCq M2nNcWROW09? MkK2TWM2OD1{OUSgcm0> MkTpNlM5PDRyM{i=
JRT3-T35 MmXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfVbpUyOCEQvF2= MYm3NkBp NVfTcVNKTE2VTx?= M4jKVGlEPTB;Mkm1JI5O MXOyN|g1PDB|OB?=
SK-MES-1 M{K2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHzN3AyOCEQvF2= MVi3NkBp M3zwXGROW09? NUGxWolZUUN3ME2zNlkhdk1? M1PxclI{QDR2MEO4
CESS MmLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES1WHAyOCEQvF2= NHTvOlQ4OiCq MVfEUXNQ MXLJR|UxRTR7NzDuUS=> NGDm[lMzOzh2NECzPC=>
H4 NYq0Um1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fOSVExKM7:TR?= M3jIclczKGh? M{fScGROW09? M2H4emlEPTB;NkG5JI5O NXH6Nmp7OjN6NESwN|g>
BC-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{ftPVExKM7:TR?= M1fjUFczKGh? NVjBflM4TE2VTx?= NIP5XIJKSzVyPUewOEBvVQ>? NFr2[GMzOzh2NECzPC=>
DB NXHrRXYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnINVAh|ryP NHnxSY44OiCq M4fOVGROW09? MVXJR|UxRTh5MzDuUS=> M3y0cFI{QDR2MEO4
RPMI-6666 M3S2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvvXYEyOCEQvF2= NIrROW04OiCq MWTEUXNQ MnnJTWM2OD17Mkigcm0> MmqxNlM5PDRyM{i=
MC/CAR MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\hXnMyOCEQvF2= M1;VS|czKGh? M1\hcGROW09? M4Lq[mlEPTB;MT6wNFIh|ryP MljuNlM5PDRyM{i=
SNU-1 M3fV[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXSxNEDPxE1? NF3GV484OiCq MUnEUXNQ NIjlO|NKSzVyPUGuOVAyKM7:TR?= MV:yN|g1PDB|OB?=
CEM/C1 NF36Z4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXWxNEDPxE1? MXu3NkBp NIDIbIRFVVOR MYTJR|UxRTFwN{ezJO69VQ>? MUeyN|g1PDB|OB?=
GDM-1 MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{ezU|ExKM7:TR?= MkDoO|IhcA>? M2jWc2ROW09? M4Tte2lEPTB;MT65PVch|ryP MoXwNlM5PDRyM{i=
HT-1080 M1OyOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXSxNEDPxE1? NF;VeYI4OiCq MUTEUXNQ M2r2SWlEPTB;Mj6wNFQh|ryP NV3uW5k2OjN6NESwN|g>
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786-O NIHjephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvyNVAh|ryP NXLJNXJ[PzJiaB?= MYnEUXNQ MnO1TWM2OD1zMDFOwG0> NV3TTItMOjN6NESwN|g>
A172 NG\ROHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYCxNEDPxE1? NY[0b|hIPzJiaB?= MkDvSG1UVw>? MlrRTWM2OD1zMDFOwG0> NIj0T5UzOzh2NECzPC=>
A204 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfUWFhCOTBizszN NFS2Sms4OiCq M3S4fGROW09? NF;tRW1KSzVyPUGwJO69VQ>? MV6yN|g1PDB|OB?=
A427 M4XlSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDzU|g3OTBizszN NUXv[|d1PzJiaB?= MoW3SG1UVw>? NVr3ZVFlUUN3ME2xNEDPxE1? NULBZmI2OjN6NESwN|g>
A431 NWXZWnJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYOxNEDPxE1? NWjZXIN[PzJiaB?= MnzzSG1UVw>? NWW0fJJzUUN3ME2xNEDPxE1? M3zmblI{QDR2MEO4
A2780 NGryblFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXWxNEDPxE1? NEHER|U4OiCq MUHEUXNQ MXjJR|UxRTFyIN88US=> MlTvNlM5PDRyM{i=
ARH-77 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlizNVAh|ryP NWnkUnZmPzJiaB?= MX7EUXNQ NYexSpppUUN3ME2xNEDPxE1? NV\Pc4w{OjN6NESwN|g>
Be(2)C NFy3ZYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfrOVZ[OTBizszN Mn3kO|IhcA>? M2r6WWROW09? MW\JR|UxRTFyIN88US=> NUf2PJQ3OjN6NESwN|g>
BT-20 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHFNW8yOCEQvF2= NWi2cId5PzJiaB?= Ml7SSG1UVw>? NGWwcmZKSzVyPUGwJO69VQ>? M1nGR|I{QDR2MEO4
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CAL-27 NXfuRZpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWSwVY9UOTBizszN NELWdnM4OiCq MYfEUXNQ MnPVTWM2OD1zMDFOwG0> MkPCNlM5PDRyM{i=
CAL-62 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrINVAh|ryP MXG3NkBp NVntdVdbTE2VTx?= NX21co43UUN3ME2xNEDPxE1? NVHqbGV3OjN6NESwN|g>
Calu-3 NHns[VBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvtV3NFOTBizszN M37NUVczKGh? MWTEUXNQ MVHJR|UxRTFyIN88US=> MWmyN|g1PDB|OB?=
CaOV3 NWfCRmVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXSxNEDPxE1? NXjvbZJvPzJiaB?= NFLJVHJFVVOR M2C1TmlEPTB;MUCg{txO MoDONlM5PDRyM{i=
CGTHW1 NUS0NXlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFO5dpEyOCEQvF2= MkLBO|IhcA>? NIHiUZpFVVOR NG\2cldKSzVyPUGwJO69VQ>? NHT4cm0zOzh2NECzPC=>
CHL-1 M3PrOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnseXpTOTBizszN NWfTZ5ZlPzJiaB?= NWTUW|N{TE2VTx?= NGKye|VKSzVyPUGwJO69VQ>? NYjkSWR3OjN6NESwN|g>
Colo320DM NHPTW5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\nNVAh|ryP NHi5OVM4OiCq MVfEUXNQ MXzJR|UxRTFyIN88US=> MoLGNlM5PDRyM{i=
Colo704 NFnRe2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWexNEDPxE1? NV;IWpR{PzJiaB?= M3XKSWROW09? NV3lNXN1UUN3ME2xNEDPxE1? NVS1VWNOOjN6NESwN|g>
COR-L23 MoXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDv[nEyOCEQvF2= NH3MPHU4OiCq NH7mZWNFVVOR MYrJR|UxRTFyIN88US=> NVXXfWM1OjN6NESwN|g>
CRO-AP2 NX7ZT3J4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Xnd|ExKM7:TR?= Ml;PO|IhcA>? M1W2NGROW09? M17uc2lEPTB;MUCg{txO M4rSNVI{QDR2MEO4
Daudi MmHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\i[VExKM7:TR?= MkDjO|IhcA>? M4jNWWROW09? M4nUfGlEPTB;MUCg{txO NUi2[INqOjN6NESwN|g>
DOTC 24510 NIHLdpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XrdlExKM7:TR?= NHTERlM4OiCq MYfEUXNQ MUnJR|UxRTFyIN88US=> NEjySYkzOzh2NECzPC=>
DU-145 NVjVbm02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e1SFExKM7:TR?= NITGdG84OiCq NF\SOGdFVVOR NISxXJZKSzVyPUGwJO69VQ>? NEfq[2QzOzh2NECzPC=>
EB-3 NXr5T241T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWmxNEDPxE1? MXm3NkBp MWHEUXNQ NWDXdVZ6UUN3ME2xNEDPxE1? M2X2NVI{QDR2MEO4
EFM-19 M33Bfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nqNFExKM7:TR?= MYW3NkBp NY[3d3Z6TE2VTx?= NXHRe3hDUUN3ME2xNEDPxE1? M{OxZlI{QDR2MEO4
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FaDu MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[3R|ExKM7:TR?= NG\vUFY4OiCq MnrkSG1UVw>? NUXVUohxUUN3ME2xNEDPxE1? NXrMT2hUOjN6NESwN|g>
G401 M4nyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HMcFExKM7:TR?= NEX1UHE4OiCq MlXlSG1UVw>? Mm\hTWM2OD1zMDFOwG0> NV7kWJhCOjN6NESwN|g>
HCC-70 NWW1ZldCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITYSlYyOCEQvF2= MVm3NkBp MnLTSG1UVw>? MmTaTWM2OD1zMDFOwG0> NYPY[|ZbOjN6NESwN|g>
HCC-1954 NFXQSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\2NVAh|ryP M{PFflczKGh? M1rjZmROW09? M2fMWGlEPTB;MUCg{txO NIrERnYzOzh2NECzPC=>
Hela NEXvVXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jMfVExKM7:TR?= NEThRZE4OiCq M4m1N2ROW09? MoP1TWM2OD1zMDFOwG0> NWnR[XV2OjN6NESwN|g>
Hep3B NVP6TG9KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVOxNEDPxE1? NHTYVI84OiCq M1fK[WROW09? NYLNZ4duUUN3ME2xNEDPxE1? M3PtVFI{QDR2MEO4
HMCB MljJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXGxNEDPxE1? MnK0O|IhcA>? NHv0eXdFVVOR NXTkU|hXUUN3ME2xNEDPxE1? M{fmWVI{QDR2MEO4
HN5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlO3NVAh|ryP M{\iSVczKGh? NVezTo9LTE2VTx?= NH:xPVZKSzVyPUGwJO69VQ>? NFnNO2YzOzh2NECzPC=>
HOS NE[3R4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi0dGtTOTBizszN MmTIO|IhcA>? M2L4OGROW09? NX3KPIFRUUN3ME2xNEDPxE1? Mo\UNlM5PDRyM{i=
HPAF-II NWPTOGM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX6xNEDPxE1? NX7OV3YzPzJiaB?= MmrnSG1UVw>? M4nGUmlEPTB;MUCg{txO NV3OcodGOjN6NESwN|g>
Hs746.T NUTJNYZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrTZW8yOCEQvF2= NF7HdIQ4OiCq NXvoUW9YTE2VTx?= MUXJR|UxRTFyIN88US=> M{\nTFI{QDR2MEO4
HT M{HBVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnJT25vOTBizszN NEnWZXo4OiCq MWPEUXNQ M1PmXGlEPTB;MUCg{txO NHPtbW0zOzh2NECzPC=>
HT-3 NFPZeWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7MNVAh|ryP MlfZO|IhcA>? MoDFSG1UVw>? MlXZTWM2OD1zMDFOwG0> Mo\FNlM5PDRyM{i=
HuNS-1 NH7YcItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVOxNEDPxE1? MmWzO|IhcA>? MmfISG1UVw>? M4LzT2lEPTB;MUCg{txO MWGyN|g1PDB|OB?=
IGROV1 NEXKVI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXixNEDPxE1? M3TKWFczKGh? NHvpZYdFVVOR MWXJR|UxRTFyIN88US=> Ml7tNlM5PDRyM{i=
J82 NFf3dIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWySHFvOTBizszN MWW3NkBp MVXEUXNQ NGfafZdKSzVyPUGwJO69VQ>? MnLxNlM5PDRyM{i=
JM1 MnPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3m[mUyOCEQvF2= NF\nXHc4OiCq M2npOGROW09? NYHMZ41kUUN3ME2xNEDPxE1? MWqyN|g1PDB|OB?=
Kato III MnfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUmxNEDPxE1? NXK4N4g4PzJiaB?= MkjFSG1UVw>? NVfrVGJDUUN3ME2xNEDPxE1? NXfrdYlLOjN6NESwN|g>
KHOS-240S MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Pad|ExKM7:TR?= NWjiTpJiPzJiaB?= Mk\vSG1UVw>? NX7HXHV6UUN3ME2xNEDPxE1? NWnJVJdOOjN6NESwN|g>
KM-12 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLGNVAh|ryP NGXRe5M4OiCq NFy0d4xFVVOR MmnJTWM2OD1zMDFOwG0> NHqxXokzOzh2NECzPC=>
KPL-1 NXuxUodlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PsOVExKM7:TR?= MVq3NkBp M3vhO2ROW09? M1PXfWlEPTB;MUCg{txO MYGyN|g1PDB|OB?=
KYSE-30 MlTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnrZYcyOCEQvF2= MVq3NkBp NGr3[mNFVVOR M1fvN2lEPTB;MUCg{txO MVSyN|g1PDB|OB?=
LNCaP NHPmOVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\xZ|ExKM7:TR?= MVu3NkBp MlOxSG1UVw>? NFv2dphKSzVyPUGwJO69VQ>? Mlv3NlM5PDRyM{i=
MCF-7 NVHobml5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoS5NVAh|ryP MoLRO|IhcA>? M2PLcGROW09? M3HzXmlEPTB;MUCg{txO MnHLNlM5PDRyM{i=
MC-IXC MornS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\2NVAh|ryP NXrueo9uPzJiaB?= MkfMSG1UVw>? MlXmTWM2OD1zMDFOwG0> MXmyN|g1PDB|OB?=
MDA-MB-175 VII MmDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvJNVAh|ryP MXW3NkBp M1LyNmROW09? NF7tVlZKSzVyPUGwJO69VQ>? M{nz[lI{QDR2MEO4
MDA-MB-468 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn1NVAh|ryP NWHVWnlFPzJiaB?= M1S4emROW09? MXTJR|UxRTFyIN88US=> MX2yN|g1PDB|OB?=
MiaPaCa MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIG0WYoyOCEQvF2= MlLtO|IhcA>? NIHOV5ZFVVOR NWXCeI9nUUN3ME2xNEDPxE1? NVLjWY9SOjN6NESwN|g>
Molt-4 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrJW2RGOTBizszN NVW2SnZmPzJiaB?= NUPRUoh6TE2VTx?= Ml\ZTWM2OD1zMDFOwG0> NGnDUnEzOzh2NECzPC=>
NCI-ADR/RES NEH4RVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnpNVAh|ryP MVy3NkBp MVLEUXNQ NX3GRZBZUUN3ME2xNEDPxE1? M{LNRlI{QDR2MEO4
NCI-H69 M2G3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7nPYwyOCEQvF2= MYO3NkBp NIrCOG1FVVOR NYHSTnA2UUN3ME2xNEDPxE1? MlG5NlM5PDRyM{i=
NCI-H82 M4jWSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYOxNEDPxE1? MoXFO|IhcA>? NFS1WHJFVVOR NGf1RlJKSzVyPUGwJO69VQ>? MYqyN|g1PDB|OB?=
NCI-N87 Mkn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f4SFExKM7:TR?= MmX3O|IhcA>? MnLYSG1UVw>? NYGwUYlLUUN3ME2xNEDPxE1? M3\1dlI{QDR2MEO4
NCI-H146 NWX5ZoQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXixNEDPxE1? MYK3NkBp NFOwWXFFVVOR MlOzTWM2OD1zMDFOwG0> NXv3enFPOjN6NESwN|g>
NCI-H157 NEHycYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlG3NVAh|ryP MlK2O|IhcA>? MWHEUXNQ M2\UcWlEPTB;MUCg{txO MlS2NlM5PDRyM{i=
NCI-H187 NYf6flgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDjNVAh|ryP M{TlN|czKGh? M17UdmROW09? MmrPTWM2OD1zMDFOwG0> NXnJV|FjOjN6NESwN|g>
NCI-H209 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzSNVAh|ryP MXu3NkBp M1\r[2ROW09? M3zVW2lEPTB;MUCg{txO NYe2[|czOjN6NESwN|g>
NCI-H226 NFrneYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVWxNEDPxE1? NHXsfIo4OiCq NH\mNHdFVVOR MnXYTWM2OD1zMDFOwG0> NYfLS4ltOjN6NESwN|g>
NCI-H292 M{\EPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIP6epIyOCEQvF2= MX23NkBp M3fERWROW09? NYfFWIxWUUN3ME2xNEDPxE1? MnfHNlM5PDRyM{i=
NCI-H322 M1HTXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT4VXQyOCEQvF2= MUS3NkBp NFzVV2RFVVOR MWTJR|UxRTFyIN88US=> MWCyN|g1PDB|OB?=
NCI-H358 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[4cZVpOTBizszN NWPmRVh4PzJiaB?= NISxTIpFVVOR MWTJR|UxRTFyIN88US=> NVSyUWVnOjN6NESwN|g>
NCI-H520 M2XmeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnLcI8yOCEQvF2= M373TVczKGh? NFfCeXZFVVOR MVTJR|UxRTFyIN88US=> NV\Fd4FEOjN6NESwN|g>
NCI-H526 Mn3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnOZ4hoOTBizszN NWjv[XlqPzJiaB?= MVzEUXNQ NYDldYZsUUN3ME2xNEDPxE1? MortNlM5PDRyM{i=
NCI-H630 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfqNVAh|ryP NEXkU484OiCq M{e5N2ROW09? NEXZVZhKSzVyPUGwJO69VQ>? NH60VogzOzh2NECzPC=>
NCI-H661 Ml;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2L0blExKM7:TR?= M{DIVlczKGh? MX3EUXNQ MWPJR|UxRTFyIN88US=> M13TZlI{QDR2MEO4
NCI-H716 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWWxNEDPxE1? M1HhVVczKGh? MUTEUXNQ MlP5TWM2OD1zMDFOwG0> MnfsNlM5PDRyM{i=
NCI-H1563 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfUNVAh|ryP M2TaU|czKGh? NHz5d2xFVVOR MUTJR|UxRTFyIN88US=> M3v5ZlI{QDR2MEO4
NCI-H1792 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf2UXIyOCEQvF2= NEjLUFg4OiCq M4XXR2ROW09? NHv1Z5BKSzVyPUGwJO69VQ>? M3f6N|I{QDR2MEO4
NCI-H2030 NIX6[HpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoH3NVAh|ryP NIexbFk4OiCq M{Ls[WROW09? MVrJR|UxRTFyIN88US=> Mn62NlM5PDRyM{i=
NCI-H2052 NET3U|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFT3cGgyOCEQvF2= MX63NkBp M2OxUmROW09? M3z3NGlEPTB;MUCg{txO M4joSlI{QDR2MEO4
NCI-H2122 NFe3S4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ThOlExKM7:TR?= MUW3NkBp NXPKVnZETE2VTx?= NVvTZ21XUUN3ME2xNEDPxE1? M2r0O|I{QDR2MEO4
NCI-H2228 NHLNV4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVSxNEDPxE1? NVrWUGtwPzJiaB?= NFfiTZJFVVOR NV7IdlU4UUN3ME2xNEDPxE1? MU[yN|g1PDB|OB?=
OE-19 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHnRllpOTBizszN MkPyO|IhcA>? M{nWdGROW09? NHfKS2xKSzVyPUGwJO69VQ>? M2PrTFI{QDR2MEO4
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SCC-15 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVWxNEDPxE1? NUDsd2VRPzJiaB?= NXX0TZI{TE2VTx?= NF:2R2RKSzVyPUGwJO69VQ>? NIq4cGgzOzh2NECzPC=>
SCC-25 NV;p[ZhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DpVlExKM7:TR?= NYraOXFlPzJiaB?= NXL4T3RZTE2VTx?= NVLN[3M{UUN3ME2xNEDPxE1? MXuyN|g1PDB|OB?=
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TK-10 NYjG[XNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PLWlExKM7:TR?= MX[3NkBp MVzEUXNQ MWPJR|UxRTFyIN88US=> MnzhNlM5PDRyM{i=
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U251 NWLYWJhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVyxNEDPxE1? M{fQVFczKGh? NV\LfVRZTE2VTx?= MXjJR|UxRTFyIN88US=> NWDaVGMzOjN6NESwN|g>
UACC-812 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPzVmcyOCEQvF2= Mn;sO|IhcA>? MnXwSG1UVw>? MYPJR|UxRTFyIN88US=> NUD2No83OjN6NESwN|g>
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MeWo M1zB[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{LvRWROW09? NV7NeXExUUN3MDC9JFk5PyCwTR?= NV;BU|J{OjZyMUi1NlQ>
WiDr NWriRXR6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnXNSG1UVw>? Mnm3TWM2OCB;IEe2JI5O NF;Kb4MzPjBzOEWyOC=>
Colo-205 NFLsZmJHfW6ldHnvckBie3OjeR?= Mm[xNUDPxE1? M3HW[FQh\A>? MmnLSG1UVw>? M2D5T2lv\HWlZXSgZUBpcWeqbImgZ49ueGG{YXLs[UBkd22yYXP0bY9vKHCqZX7veJlx\Q>? M2iwRlI2OzhzMUWy
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... Click to View More Cell Line Experimental Data

体内研究 Dabrafenib(口服)抑制B-RafV600E突变的黑色素瘤(A375P)的生长,在免疫受损小鼠中皮下注射结肠癌(Colo205),Dabrafenib(口服)同样能抑制肿瘤生长。 [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
30% PEG400+0.5% Tween80+5% propylene glycol
8 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 519.56
化学式

C23H20F3N5O2S2

CAS号 1195765-45-7
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01723202 Active, not recruiting Follicular Thyroid Cancer|Insular Thyroid Cancer|Papillary Thyroid Cancer|Recurrent Thyroid Cancer Manisha Shah|National Comprehensive Cancer Network|Ohio State University Comprehensive Cancer Center November 7, 2012 Phase 2
NCT02672358 Not yet recruiting Non-Small-Cell Lung Cancer Novartis Pharmaceuticals|Novartis October 2017 Phase 2
NCT02447939 Withdrawn Melanoma GlaxoSmithKline May 2017 Phase 1
NCT02967692 Not yet recruiting Melanoma Novartis Pharmaceuticals|Novartis February 2017 Phase 3
NCT02858921 Not yet recruiting Melanoma Melanoma Institute Australia|Merck Sharp & Dohme Corp.|Novartis February 2017 Phase 2
NCT03026517 Recruiting Melanoma Memorial Sloan Kettering Cancer Center|Massachusetts General Hospital|Weill Medical College of Cornell University January 2017 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Raf Signaling Pathway Map

Raf Inhibitors with Unique Features

相关Raf产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID