Dabrafenib (GSK2118436)

目录号:S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436)是一种突变型BRAFV600特异性抑制剂,无细胞试验中IC50为0.8 nM,作用于B-Raf(wt)和c-Raf效果分别低4和6倍。

规格 价格 库存 购买数量  
RMB 1481.39 现货
RMB 733.64 现货
RMB 1056.75 现货
RMB 1394.46 现货
RMB 2235.84 现货
RMB 3261.37 现货
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客户使用该产品的5个实验数据:

  • A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

    Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

  • The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

    Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

  • Western blot analysis of p-Erk and total ERK in A375 melanoma cell line after treatment with different doses of Dabrafenib for 48 hours (A). p-ERK signal was normalized with total ERK signal (B), SD and means of the normalized p-ERK values were reported.

    PLoS One, 2016, 11(3):e0152104. Dabrafenib (GSK2118436) purchased from Selleck.

产品安全说明书

Raf抑制剂选择性比较

生物活性

产品描述 Dabrafenib (GSK2118436)是一种突变型BRAFV600特异性抑制剂,无细胞试验中IC50为0.8 nM,作用于B-Raf(wt)和c-Raf效果分别低4和6倍。
靶点
B-Raf (V600E) [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
C-Raf [1]
(Cell-free assay)
0.8 nM 3.2 nM 5.0 nM
体外研究

Dabrafenib对Raf激酶具有选择性,对B-Raf的活性比其它测试过的91%的激酶高400倍。 Dabrafenib抑制B-RafV600E激酶,导致ERK磷酸化降低和抑制细胞的增值,在特异性编码突变的B-RafV600E的癌细胞中细胞停滞在G1期。

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
M{nXeGtqdmG|ZTDBd5NigQ>? MWfJcohq[mm2aX;uJI9nKE5vdHXycYlv[WxiSHnzJJRi\2enZDDCMXJi\iCYNkCwSUBufXSjboSg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIHnud4VkfCClZXzsd{Bkdy2neIDy[ZN{cW6pIFPER|M4KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJIJqd3SrbonsZZRm\C2PRVugdJJwfGWrbjDwbI9{eGixconsZZRqd25iYomgRYxxcGGVY4Ll[Y4h[XO|YYmge4l1cCCLQ{WwJI9nKDBwMECwO{DPxE1? NVzLS3FoOjR7MEC2O|M>
SK-MEL-28 M2rKV2tqdmG|ZTDBd5NigQ>? NXHqPHUzOSCq NVLybYk6UW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSgbY4hcHWvYX6gV2suVUWOLUK4JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKEWUSzDwbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFAvODB2IN88US=> Ml\tNlQ6ODB4N{O=
HepG2 M1jZN2tqdmG|ZTDBd5NigQ>? NWnpXnN{UW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSgbY4hcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP MXuyOFkxODZ5Mx?=
COLO205 MoLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon3TY5pcWKrdHnvckBw\iCqdX3hckBEV0yRMkC1JINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFch|ryP M3LOUlI1QTByNkez
HepG2 NXHaVmhMTnWwY4Tpc44hSXO|YYm= MVG0OUBucW5? MYrEUXNQ MWHJcohq[mm2aX;uJI9nKEGua{WgbY4hXEeILXLleIEue3SrbYXsZZRm\CCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBUdWGmMjDwbI9{eGixconsZZRqd25idILlZZRm\CCob4KgOFUhdWmwczDwdolweiC2bzDUS2Yu[mW2YTDzeIlufWyjdHnvckBu\WG|dYLl[EBi\nSncjC2NEBucW6|IHL5JI9lgXO|ZYmgZoxwfCC|Y3HucoVzKGGwYXz5d4l{KHerdHigTWM2OCCxZjCzMlch|ryP Mmf0NlQ6ODB4N{O=
HFF MoTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DjTFExKM7:TR?= MkjJO|IhcA>? MnHtSG1UVw>? NUnaVld[UW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIHj1cYFvKEiIRjDj[YxteyCqYYLic5Jqdmdid3ns[EB1gXCnIFKtVoFnKHerdHigTWM2OCCxZjCzJO69VQ>? M4\ONlI{QDR2MEO4
SK-MEL-28 M4i4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\rNVAh|ryP M4fsbVczKGh? NWPTSVE2TE2VTx?= MlS4TY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKFONLV3FUE0zQCClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODR|IN88US=> MXiyN|g1PDB|OB?=
A375P-F11 NGjWeHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnE[olJOTBizszN MU[3NkBp NInFWpJFVVOR MmLDTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKEF|N{XQMWYyOSClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODdzIN88US=> M2D2[VI{QDR2MEO4
MALME-3M M2TSNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4e3XFExKM7:TR?= NVLYRYRPPzJiaB?= MlTsSG1UVw>? NGDxToZKSzVyPUGgcm0> Ml3jNlM5PDRyM{i=
UACC-62 MkKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX4R4wyOCEQvF2= MlHkO|IhcA>? MYTEUXNQ MoXYTWM2OD1zIH7N NYHSW4VCOjN6NESwN|g>
C32TG M4PnSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnjc4cyOCEQvF2= MlzFO|IhcA>? MYfEUXNQ NHzNVYZKSzVyPUGgcm0> M1TpTlI{QDR2MEO4
SK-MEL-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfsNVAh|ryP NFrQUZE4OiCq NH30TlhFVVOR NX7uUYh3UUN3ME2yJI5O MWKyN|g1PDB|OB?=
M14 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWOxNEDPxE1? MoXLO|IhcA>? NVzkSHAyTE2VTx?= NXTGWopIUUN3ME2yJI5O NVTCTnhGOjN6NESwN|g>
SK-MEL-28 NELqc5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHVNVAh|ryP NYjze2Q5PzJiaB?= MWHEUXNQ NVrRNmg5UUN3ME2zJI5O NYrpb21zOjN6NESwN|g>
A375 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2WzelExKM7:TR?= Mn\OO|IhcA>? M3jDWWROW09? NF7HNGhKSzVyPUSgcm0> MkH6NlM5PDRyM{i=
DU-4475 NUPKdHh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPoVlZoOTBizszN MmruO|IhcA>? Mn\wSG1UVw>? MUPJR|UxRTVibl2= MXWyN|g1PDB|OB?=
UACC-257 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrycohPOTBizszN MYi3NkBp NW\tbYlMTE2VTx?= NHn5e|BKSzVyPU[gcm0> MYeyN|g1PDB|OB?=
Colo 205 NXLQ[IlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17V[lExKM7:TR?= M2HQ[|czKGh? NH;XcG5FVVOR NFPueWZKSzVyPUegcm0> M17wPVI{QDR2MEO4
SK-MEL-3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnDVWhrOTBizszN MYq3NkBp M{CxcWROW09? M4T4fWlEPTB;NzDuUS=> MmjZNlM5PDRyM{i=
SH-4 NUjMXmJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XPflExKM7:TR?= NUXjNHhyPzJiaB?= MWHEUXNQ NX7GVJZHUUN3ME24JI5O MVWyN|g1PDB|OB?=
A101D NGHPRZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHkWIVFOTBizszN M3\H[VczKGh? NWDSeGJrTE2VTx?= Ml3PTWM2OD17IH7N NVPpVXNYOjN6NESwN|g>
ES-2 MlvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUGxNEDPxE1? MWe3NkBp M1X0ZmROW09? MlzzTWM2OD13MzDuUS=> M3npeVI{QDR2MEO4
HT-29 NXvxcZdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYexNEDPxE1? NWLvZ3ZnPzJiaB?= MXzEUXNQ NIXxblFKSzVyPU[2JI5O NIDIbIozOzh2NECzPC=>
SW1417 NVTLbIpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPMcXBlOTBizszN MXy3NkBp MkL0SG1UVw>? M{PONGlEPTB;MUW4JI5O MUGyN|g1PDB|OB?=
SW872 MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYi2XFkzOTBizszN M4i2SlczKGh? M{fCPGROW09? MmLZTWM2OD1|N{egcm0> M3TXS|I{QDR2MEO4
RKO MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe1XoYyOCEQvF2= NXGxOnpXPzJiaB?= NWX0fVY6TE2VTx?= NGjyNYJKSzVyPUKuOVIzKM7:TR?= NWXNSXBUOjN6NESwN|g>
A673 M4P0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ezZ|ExKM7:TR?= M2nuUFczKGh? NH62Z3FFVVOR MkPtTWM2OD1zMDFOwG0> NUDlUJhvOjN6NESwN|g>
GCT NHPWdGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfxVJEyOCEQvF2= NFeyOXM4OiCq MnLBSG1UVw>? NFXkS29KSzVyPUGwJO69VQ>? NX25bVAxOjN6NESwN|g>
WM-115 MoLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzhNVAh|ryP M3j6R|czKGh? MYTEUXNQ NXfEeFl6UUN3ME21JI5O MXyyN|g1PDB|OB?=
YUMAC NIPhVIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrlUodyOTBizszN NUTIUXR[PzJiaB?= M4LlfmROW09? M{HjeWlEPTB;NTDuUS=> MX[yN|g1PDB|OB?=
OV-90 M3nMXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrtO|l1OTBizszN NWPHPGszPzJiaB?= Mn30SG1UVw>? MnjjTWM2OD1{OTDuUS=> NWrsRWt1OjN6NESwN|g>
NCI-H508 NGjzbY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{KxUVExKM7:TR?= NYH5WGFWPzJiaB?= MoXqSG1UVw>? M1z4UmlEPTB;MUCg{txO NUCzbHVDOjN6NESwN|g>
MDA-MB-231 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYqxNEDPxE1? MWK3NkBp NHnhdYxFVVOR MmnkTWM2OD1zMDFOwG0> MWCyN|g1PDB|OB?=
SW756 NWfUZXhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLW[XpVOTBizszN MV63NkBp MnXYSG1UVw>? MUDJR|UxRTFyIN88US=> MkG5NlM5PDRyM{i=
SW-837 NUXidnFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIju[VkyOCEQvF2= MUi3NkBp MVvEUXNQ MXTJR|UxRTFyIN88US=> NXO0TWRROjN6NESwN|g>
UMUC-3 NX\ORmNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TFe|ExKM7:TR?= Mn\MO|IhcA>? MVrEUXNQ MmKwTWM2OD1zMDFOwG0> MmexNlM5PDRyM{i=
LS-174T MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vTdVExKM7:TR?= NV\qV3lMPzJiaB?= MmPQSG1UVw>? M2DlPWlEPTB;MUCg{txO MoqyNlM5PDRyM{i=
A549 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\tVpIyOCEQvF2= NXfNRmliPzJiaB?= NYnxNoVHTE2VTx?= M1\TRmlEPTB;MUCg{txO MYKyN|g1PDB|OB?=
SHP-77 Mo\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrjcIhWOTBizszN MmfyO|IhcA>? NX;xfHZQTE2VTx?= NFTIZXVKSzVyPUGwJO69VQ>? MnHENlM5PDRyM{i=
SW480 NI\0OVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPaO4kyOCEQvF2= M1GxXFczKGh? NEH6fWRFVVOR NFjiUFNKSzVyPUGwJO69VQ>? M{HjblI{QDR2MEO4
DLD-1 MnnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvCNVAh|ryP NEj6ZZk4OiCq MXPEUXNQ NFX3PXZKSzVyPUGwJO69VQ>? M2nvRlI{QDR2MEO4
HCT-116 NYi1SW1WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnv4NVAh|ryP MnHyO|IhcA>? NVXNXoh1TE2VTx?= NFy2c21KSzVyPUGwJO69VQ>? MlL2NlM5PDRyM{i=
NCI-H747 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHiXZd4OTBizszN M{TJZlczKGh? M362PWROW09? Mmf0TWM2OD1zMDFOwG0> NGHpcFAzOzh2NECzPC=>
T-84 M3\zdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVixNEDPxE1? NG\DbWw4OiCq MljVSG1UVw>? MVnJR|UxRTFyIN88US=> M33O[lI{QDR2MEO4
NCI-H460 NIn4ZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWixNpFFOTBizszN MYq3NkBp NFntWJNFVVOR Mnu4TWM2OD1zMDFOwG0> M4XGXVI{QDR2MEO4
Calu-6 NFLqfmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXH[XUyOCEQvF2= NVrmTIdnPzJiaB?= MXHEUXNQ M{PDWmlEPTB;MUCg{txO M1PYSVI{QDR2MEO4
HCC-2998 NW\qSI42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfybVNoOTBizszN MXi3NkBp NHf6fVNFVVOR NYTIZ3VoUUN3ME2xNEDPxE1? M2DPelI{QDR2MEO4
LS1034 NVnRNGRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HTcVExKM7:TR?= MVe3NkBp MXnEUXNQ MoPYTWM2OD1zMDFOwG0> M{LZW|I{QDR2MEO4
CHP-212 NFHR[HdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jEfFExKM7:TR?= M{ToTVczKGh? NWjqZ|l3TE2VTx?= NIPje3BKSzVyPUGwJO69VQ>? NIqzS5YzOzh2NECzPC=>
SK-N-AS MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPRPJkxOTBizszN M3vxdlczKGh? NX;OVYVyTE2VTx?= NHrIOopKSzVyPUGwJO69VQ>? M2DqXVI{QDR2MEO4
BFTC-905 NWDH[49ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq3NXB2OTBizszN M1fvUVczKGh? MVvEUXNQ NYT6S2tWUUN3ME2xNEDPxE1? M1q2dlI{QDR2MEO4
HuT78 M{ezWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknBNVAh|ryP NGrIRYw4OiCq NYj6dY9LTE2VTx?= NXfiO2lNUUN3ME21NkBvVQ>? Mmf6NlM5PDRyM{i=
RPMI-8226 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nu[VExKM7:TR?= NE\NN5E4OiCq NX3VOJV4TE2VTx?= MUTJR|UxRTJ4MzDuUS=> MVmyN|g1PDB|OB?=
BC-3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NID3VGgyOCEQvF2= NYPXPFdXPzJiaB?= NEP5cnlFVVOR NX23WoZ3UUN3ME2yO|chdk1? MXKyN|g1PDB|OB?=
ACHN MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\HcFExKM7:TR?= MnL0O|IhcA>? NVnLN2t2TE2VTx?= MVHJR|UxRTJ7NDDuUS=> M3HaZlI{QDR2MEO4
JRT3-T35 NF\LPW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvhdlcyOCEQvF2= Mn\yO|IhcA>? MoLtSG1UVw>? MYLJR|UxRTJ7NTDuUS=> NIL4UY8zOzh2NECzPC=>
SK-MES-1 NHziXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXBNVAh|ryP M3HxblczKGh? M13od2ROW09? NIXtWGlKSzVyPUOyPUBvVQ>? M1TNc|I{QDR2MEO4
CESS MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUSxNEDPxE1? NI\oeZg4OiCq M2rOZmROW09? NF63XYpKSzVyPUS5O{BvVQ>? M1nTSVI{QDR2MEO4
H4 M{HGTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfESnMyOCEQvF2= MnPUO|IhcA>? MoLzSG1UVw>? MkTLTWM2OD14MUmgcm0> MkKyNlM5PDRyM{i=
BC-1 NFrnXo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLqZoQyOCEQvF2= NVm3VnBLPzJiaB?= NEnWRmpFVVOR Ml22TWM2OD15MESgcm0> M2PS[|I{QDR2MEO4
DB NGTJOHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWyT3JoOTBizszN MXy3NkBp NGHa[nFFVVOR NXfVT|l7UUN3ME24O|Mhdk1? M2PmbFI{QDR2MEO4
RPMI-6666 NInwTYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYqxNEDPxE1? NG\6bFI4OiCq NX;ubYtVTE2VTx?= M{PMcGlEPTB;OUK4JI5O MYGyN|g1PDB|OB?=
MC/CAR MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXYWmYyOCEQvF2= MmLlO|IhcA>? NWrMZpdLTE2VTx?= M33SU2lEPTB;MT6wNFIh|ryP MXyyN|g1PDB|OB?=
SNU-1 MoPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDpe4JLOTBizszN NIXCd4I4OiCq NVX4fGJCTE2VTx?= NVrWSJhPUUN3ME2xMlUxOSEQvF2= NYXJTphOOjN6NESwN|g>
CEM/C1 NIj0PGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV:xNEDPxE1? M3vIPVczKGh? NHzHV3NFVVOR NEPONJBKSzVyPUGuO|c{KM7:TR?= NEjkTHMzOzh2NECzPC=>
GDM-1 NUHmUYVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXmxNEDPxE1? M4HRV|czKGh? MWPEUXNQ MX\JR|UxRTFwOUm3JO69VQ>? M2jQe|I{QDR2MEO4
HT-1080 MnOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIny[pkyOCEQvF2= M{j6[FczKGh? NXrWNphlTE2VTx?= MXHJR|UxRTJwMEC0JO69VQ>? NF\xbG8zOzh2NECzPC=>
HL-60 NUnN[Hd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVGxNEDPxE1? MnT3O|IhcA>? NU\HUVNSTE2VTx?= MX3JR|UxRTJwMUe4JO69VQ>? MX2yN|g1PDB|OB?=
C3A NV30c3NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjyNVAh|ryP MVG3NkBp M3\jOGROW09? MmewTWM2OD13LkSxOEDPxE1? MYCyN|g1PDB|OB?=
MES-SA NIPEXmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M364ZVExKM7:TR?= MVK3NkBp MWHEUXNQ MonYTWM2OD14Lkm4PUDPxE1? NYXH[HNnOjN6NESwN|g>
22Rv1 M2q2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\qOFExKM7:TR?= M4TwOVczKGh? MoXCSG1UVw>? MnfXTWM2OD1zMDFOwG0> NEX3XGkzOzh2NECzPC=>
647-V MmrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTUNVAh|ryP M1P4VlczKGh? NH7BO3dFVVOR MYXJR|UxRTFyIN88US=> MlrqNlM5PDRyM{i=
786-O M1;RO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;pNVAh|ryP NHjiXmg4OiCq M4H0U2ROW09? NFvzN49KSzVyPUGwJO69VQ>? MnjnNlM5PDRyM{i=
A172 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX4V20yOCEQvF2= NHjlU|g4OiCq NF2wUpJFVVOR M{jzeWlEPTB;MUCg{txO NYfIZ2F3OjN6NESwN|g>
A204 M4myVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDtUlFxOTBizszN NV;icItDPzJiaB?= MYLEUXNQ MV\JR|UxRTFyIN88US=> MUSyN|g1PDB|OB?=
A427 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYe3V4FLOTBizszN M2P6VVczKGh? MV;EUXNQ M{jrd2lEPTB;MUCg{txO MV[yN|g1PDB|OB?=
A431 NYnMW5lmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLZUlQyOCEQvF2= NGfaXIs4OiCq M4OyfmROW09? NFL1eIVKSzVyPUGwJO69VQ>? MkLUNlM5PDRyM{i=
A2780 NEDiSopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;rWFExKM7:TR?= NH3vV|k4OiCq MW\EUXNQ M{S4U2lEPTB;MUCg{txO M3XBVFI{QDR2MEO4
ARH-77 NHjVfItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XSZVExKM7:TR?= NH\vfGk4OiCq MWrEUXNQ MVXJR|UxRTFyIN88US=> MXGyN|g1PDB|OB?=
Be(2)C M{TX[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3aN3oyOCEQvF2= NV;ySHF1PzJiaB?= NFfF[mpFVVOR MoDCTWM2OD1zMDFOwG0> M1Lo[FI{QDR2MEO4
BT-20 M2THS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWOxNEDPxE1? NFu1R|c4OiCq M{DZV2ROW09? MXTJR|UxRTFyIN88US=> Ml;oNlM5PDRyM{i=
BxPc3 M3y5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrDSoh6OTBizszN MorGO|IhcA>? NHvRZ4lFVVOR NFG3XXlKSzVyPUGwJO69VQ>? MW[yN|g1PDB|OB?=
C-4 I M1LtOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHMXnpiOTBizszN NVK0UmxmPzJiaB?= NWXjdG9UTE2VTx?= M1mwVWlEPTB;MUCg{txO MWmyN|g1PDB|OB?=
C33A MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnvW411OTBizszN MoS2O|IhcA>? MnLtSG1UVw>? M1W0WmlEPTB;MUCg{txO M4jjZVI{QDR2MEO4
CAL-27 NXXyTVlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;5NXQyOCEQvF2= MWW3NkBp NFzvVGhFVVOR MoiyTWM2OD1zMDFOwG0> NHLJPY4zOzh2NECzPC=>
CAL-62 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIKwWIcyOCEQvF2= MUm3NkBp MYDEUXNQ MXTJR|UxRTFyIN88US=> MUmyN|g1PDB|OB?=
Calu-3 MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWCxNEDPxE1? M3:xcFczKGh? MlTOSG1UVw>? Mnz5TWM2OD1zMDFOwG0> M4LIOlI{QDR2MEO4
CaOV3 MnTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULw[XNkOTBizszN MonBO|IhcA>? NVr3bGRLTE2VTx?= MVvJR|UxRTFyIN88US=> M3GzSFI{QDR2MEO4
CGTHW1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;iToNuOTBizszN NWLsS3piPzJiaB?= NHrpS3JFVVOR MkH0TWM2OD1zMDFOwG0> NVW0NFBFOjN6NESwN|g>
CHL-1 M3r5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPmNVAh|ryP NGTK[Yc4OiCq NWPtSm9zTE2VTx?= MoLhTWM2OD1zMDFOwG0> NX\mUFZPOjN6NESwN|g>
Colo320DM NGL2cm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPxRodoOTBizszN MoHuO|IhcA>? Mnz5SG1UVw>? MknFTWM2OD1zMDFOwG0> MojPNlM5PDRyM{i=
Colo704 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\oS|AxOTBizszN MknSO|IhcA>? M1zyWWROW09? M1;ETGlEPTB;MUCg{txO NED3NIQzOzh2NECzPC=>
COR-L23 NV;3NXRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXZNVAh|ryP M4nGWVczKGh? NGXDOnhFVVOR M2XENWlEPTB;MUCg{txO MWOyN|g1PDB|OB?=
CRO-AP2 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHUW5IyOCEQvF2= M2TWWlczKGh? NHPT[o5FVVOR MYLJR|UxRTFyIN88US=> Ml\LNlM5PDRyM{i=
Daudi M4HoeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYW0V5dROTBizszN NGDFc|c4OiCq NXX5WIE{TE2VTx?= MlHLTWM2OD1zMDFOwG0> MV:yN|g1PDB|OB?=
DOTC 24510 MnWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUSxNEDPxE1? M4\COlczKGh? MlnuSG1UVw>? MnO3TWM2OD1zMDFOwG0> NYPibWZTOjN6NESwN|g>
DU-145 MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnn[5AzOTBizszN M4XqeFczKGh? NYTvfIM5TE2VTx?= NWXoS5p5UUN3ME2xNEDPxE1? NHXWclQzOzh2NECzPC=>
EB-3 MmjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq3NVAh|ryP NWPMO2dGPzJiaB?= M1nESmROW09? MlHxTWM2OD1zMDFOwG0> M330V|I{QDR2MEO4
EFM-19 M1T3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rNbFExKM7:TR?= NEDWNWk4OiCq MnmxSG1UVw>? NUfpbGxuUUN3ME2xNEDPxE1? M1jxTlI{QDR2MEO4
EKVX Mmf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[xNEDPxE1? M3zIfVczKGh? MWPEUXNQ MXPJR|UxRTFyIN88US=> M4PHclI{QDR2MEO4
FaDu NWrNWVRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7RNVAh|ryP NWL4cJdzPzJiaB?= M4WzVGROW09? MUnJR|UxRTFyIN88US=> NF;wV2UzOzh2NECzPC=>
G401 MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XifFExKM7:TR?= MXi3NkBp NV7sWpoxTE2VTx?= MUTJR|UxRTFyIN88US=> NFzvRWIzOzh2NECzPC=>
HCC-70 NHLHNZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnsNVAh|ryP NHvETIo4OiCq NXTyNGY5TE2VTx?= M{PEfGlEPTB;MUCg{txO M{S5d|I{QDR2MEO4
HCC-1954 NWDnT4xFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrjVVEyOCEQvF2= NYLBUnBNPzJiaB?= NVH1RoxYTE2VTx?= NXn2TZgyUUN3ME2xNEDPxE1? NV\yc4JXOjN6NESwN|g>
Hela MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;p[Y1{OTBizszN MWi3NkBp Mmr4SG1UVw>? MXHJR|UxRTFyIN88US=> NWrhT4prOjN6NESwN|g>
Hep3B NH[2TIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfFcHlQOTBizszN M{\6S|czKGh? NXK3UGNOTE2VTx?= MVHJR|UxRTFyIN88US=> M2TaUFI{QDR2MEO4
HMCB M2LRdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LrdlExKM7:TR?= M2jOeVczKGh? Mn\TSG1UVw>? MnyyTWM2OD1zMDFOwG0> MVyyN|g1PDB|OB?=
HN5 M4LzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HUcFExKM7:TR?= NXvVToVDPzJiaB?= Mo\jSG1UVw>? NFLyc2ZKSzVyPUGwJO69VQ>? NFLyV2kzOzh2NECzPC=>
HOS NInu[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorSNVAh|ryP NXzxNG9UPzJiaB?= MV\EUXNQ M3f0bWlEPTB;MUCg{txO NWO0eVRFOjN6NESwN|g>
HPAF-II NF7XdVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWSxNEDPxE1? NGK1dWs4OiCq NILld49FVVOR MU\JR|UxRTFyIN88US=> NUT2W4hQOjN6NESwN|g>
Hs746.T NF3zOo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLTNVAh|ryP NETKTYE4OiCq NVrzOXp7TE2VTx?= Mm\UTWM2OD1zMDFOwG0> NU[3[YFSOjN6NESwN|g>
HT Ml\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jWdVExKM7:TR?= M4HMW|czKGh? NULqWVN4TE2VTx?= NWfIWmR7UUN3ME2xNEDPxE1? MmC4NlM5PDRyM{i=
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HuNS-1 MnvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXmxNEDPxE1? M1ftcFczKGh? NWm0U2RHTE2VTx?= NVO4fW5oUUN3ME2xNEDPxE1? NHG0UpUzOzh2NECzPC=>
IGROV1 M{\OUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUKxNEDPxE1? M1y2VFczKGh? NXjjSFJ[TE2VTx?= NF22fXFKSzVyPUGwJO69VQ>? MXSyN|g1PDB|OB?=
J82 M3vJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjxZXdTOTBizszN Mm\MO|IhcA>? NWi3W2M6TE2VTx?= M3vrW2lEPTB;MUCg{txO MkPzNlM5PDRyM{i=
JM1 M13CUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV[xNEDPxE1? NGSzcZg4OiCq M{fYfWROW09? NHHxS3NKSzVyPUGwJO69VQ>? NWjTSHUxOjN6NESwN|g>
Kato III NGjMe4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7CT40yOCEQvF2= NYPIc2h4PzJiaB?= M4mwTmROW09? MVXJR|UxRTFyIN88US=> M3vJUVI{QDR2MEO4
KHOS-240S NEfr[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU[xNEDPxE1? NUXPZmNQPzJiaB?= MVzEUXNQ MUPJR|UxRTFyIN88US=> NWTCWVZxOjN6NESwN|g>
KM-12 NUTxWYpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHnNVAh|ryP NWTVeWtnPzJiaB?= NFvIO3RFVVOR NH;PTFFKSzVyPUGwJO69VQ>? MknYNlM5PDRyM{i=
KPL-1 M1zib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHIOItpOTBizszN MUe3NkBp Ml;OSG1UVw>? MXjJR|UxRTFyIN88US=> NX7nOnJuOjN6NESwN|g>
KYSE-30 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PlSVExKM7:TR?= M3The|czKGh? M2\Y[2ROW09? MnPPTWM2OD1zMDFOwG0> MVeyN|g1PDB|OB?=
LNCaP NH;5ZYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjkWngyOCEQvF2= NEfN[Xc4OiCq NIn6RldFVVOR NXfiT|FYUUN3ME2xNEDPxE1? NHX4fpIzOzh2NECzPC=>
MCF-7 NGSze2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4j6OlExKM7:TR?= M1zR[lczKGh? MVnEUXNQ NV3yNlA5UUN3ME2xNEDPxE1? NVrWc5prOjN6NESwN|g>
MC-IXC MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\tNVAh|ryP NYHpc5FSPzJiaB?= MX;EUXNQ NFHUZ2VKSzVyPUGwJO69VQ>? NEnzNIUzOzh2NECzPC=>
MDA-MB-175 VII MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17rO|ExKM7:TR?= MmHmO|IhcA>? M1rvWWROW09? Ml3pTWM2OD1zMDFOwG0> NVHHZ3ZrOjN6NESwN|g>
MDA-MB-468 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfQZmcyOCEQvF2= MWq3NkBp NUXlOpQ1TE2VTx?= NX;Fd5M4UUN3ME2xNEDPxE1? NF7NUZozOzh2NECzPC=>
MiaPaCa NYnWVXdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjPOlYyOCEQvF2= NVXhUY1YPzJiaB?= MoTISG1UVw>? M3HtV2lEPTB;MUCg{txO NIC0ZYYzOzh2NECzPC=>
Molt-4 NVHleZNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVKxNEDPxE1? Ml\vO|IhcA>? MUDEUXNQ M13LVGlEPTB;MUCg{txO NV20OIpXOjN6NESwN|g>
NCI-ADR/RES NFyxR4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HyclExKM7:TR?= MlTUO|IhcA>? MnzlSG1UVw>? MlzLTWM2OD1zMDFOwG0> M4ewUFI{QDR2MEO4
NCI-H69 MkewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorhNVAh|ryP NHP6V4U4OiCq Ml3VSG1UVw>? MmPrTWM2OD1zMDFOwG0> MX2yN|g1PDB|OB?=
NCI-H82 Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfDWGYyOCEQvF2= M2m5SVczKGh? NILGemxFVVOR M1XOV2lEPTB;MUCg{txO M1HYd|I{QDR2MEO4
NCI-N87 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrJNVAh|ryP MYS3NkBp MlfnSG1UVw>? MonyTWM2OD1zMDFOwG0> NVjSW4tvOjN6NESwN|g>
NCI-H146 MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUGxNEDPxE1? MnruO|IhcA>? MnPwSG1UVw>? NGH6RplKSzVyPUGwJO69VQ>? MX6yN|g1PDB|OB?=
NCI-H157 M2DrTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHJWo8yOCEQvF2= M4Phc|czKGh? M{j2OmROW09? MV;JR|UxRTFyIN88US=> NGfBU5UzOzh2NECzPC=>
NCI-H187 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF:4ZVMyOCEQvF2= Mn7PO|IhcA>? MX\EUXNQ MUXJR|UxRTFyIN88US=> M4r3VlI{QDR2MEO4
NCI-H209 NWqweFJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWWxNEDPxE1? M2DlR|czKGh? NHjOOnBFVVOR MnOwTWM2OD1zMDFOwG0> MU[yN|g1PDB|OB?=
NCI-H226 NIHHfnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MluyNVAh|ryP MVS3NkBp MmjXSG1UVw>? MmD1TWM2OD1zMDFOwG0> NVnpS4FCOjN6NESwN|g>
NCI-H292 M1zE[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjQd4ltOTBizszN M3n2NlczKGh? MmLESG1UVw>? NWjxVXFZUUN3ME2xNEDPxE1? NYr6WFc{OjN6NESwN|g>
NCI-H322 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjrO|NbOTBizszN MlTGO|IhcA>? NXiyWIZwTE2VTx?= NF7VSVdKSzVyPUGwJO69VQ>? Moe2NlM5PDRyM{i=
NCI-H358 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojzNVAh|ryP M3v1e|czKGh? M{e1OmROW09? NFn2e5RKSzVyPUGwJO69VQ>? MV[yN|g1PDB|OB?=
NCI-H520 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTrNVAh|ryP M1SzN|czKGh? MkTBSG1UVw>? MV\JR|UxRTFyIN88US=> NXrOcZhvOjN6NESwN|g>
NCI-H526 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVmxNEDPxE1? NWP1VXQ2PzJiaB?= NFK0TnRFVVOR MYrJR|UxRTFyIN88US=> Ml3oNlM5PDRyM{i=
NCI-H630 NUjjcnM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4T0clExKM7:TR?= MnXKO|IhcA>? MVfEUXNQ NYWw[FF2UUN3ME2xNEDPxE1? M3LZS|I{QDR2MEO4
NCI-H661 NUPYOGxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TjTFExKM7:TR?= MYm3NkBp MVvEUXNQ NXLUO41UUUN3ME2xNEDPxE1? M3nIbVI{QDR2MEO4
NCI-H716 M1zuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILJNlAyOCEQvF2= MoTCO|IhcA>? NXu2[GFlTE2VTx?= MVzJR|UxRTFyIN88US=> NU\SXnlQOjN6NESwN|g>
NCI-H1563 NVS2cI9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfQSJEyOCEQvF2= NXzz[HJIPzJiaB?= M2PISWROW09? M1rwdmlEPTB;MUCg{txO M1zi[|I{QDR2MEO4
NCI-H1792 M4DBTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXWxNEDPxE1? MnLlO|IhcA>? Mn7NSG1UVw>? Ml3PTWM2OD1zMDFOwG0> MnHrNlM5PDRyM{i=
NCI-H2030 NGLWOVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn6wNVAh|ryP NWfBenR7PzJiaB?= MWDEUXNQ NGrV[HVKSzVyPUGwJO69VQ>? M2CxeVI{QDR2MEO4
NCI-H2052 NF\aO2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkG2NVAh|ryP NGrlT2U4OiCq NX\nbZU1TE2VTx?= NEjlVXhKSzVyPUGwJO69VQ>? NI[2Z|EzOzh2NECzPC=>
NCI-H2122 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWGxNEDPxE1? Ml3YO|IhcA>? NFP5T4FFVVOR NFLJcnBKSzVyPUGwJO69VQ>? NFTMeZkzOzh2NECzPC=>
NCI-H2228 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n4W|ExKM7:TR?= M2LFXlczKGh? NUDmOnplTE2VTx?= M4DSN2lEPTB;MUCg{txO NH;mTJYzOzh2NECzPC=>
OE-19 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVezVJdQOTBizszN NYL1Uo5oPzJiaB?= MW\EUXNQ NWDsbJNkUUN3ME2xNEDPxE1? M3vFUVI{QDR2MEO4
OE-21 NG\jdYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX6xNEDPxE1? MmPxO|IhcA>? MkfGSG1UVw>? NH:5SIRKSzVyPUGwJO69VQ>? MlTINlM5PDRyM{i=
OE-33 NFvk[nNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUixNEDPxE1? NF;aWXg4OiCq NGnMNpdFVVOR M3e1cmlEPTB;MUCg{txO MVWyN|g1PDB|OB?=
OVCAR-3 Mo\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPwNVAh|ryP NUXPPJNlPzJiaB?= NFnpSlFFVVOR NIfXfZNKSzVyPUGwJO69VQ>? NI\SPYYzOzh2NECzPC=>
OVCAR-4 M4L1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfQNVAh|ryP MnvXO|IhcA>? MYHEUXNQ NV\VeGEyUUN3ME2xNEDPxE1? NHPqZYwzOzh2NECzPC=>
OVCAR-5 Mon5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrrNVAh|ryP NHPkeFE4OiCq MkPaSG1UVw>? NUH3OmlpUUN3ME2xNEDPxE1? MYCyN|g1PDB|OB?=
P3HR-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXqXFBNOTBizszN NEC0T3c4OiCq NX\RVoZETE2VTx?= M2q3eWlEPTB;MUCg{txO MYiyN|g1PDB|OB?=
PC-3 M4DyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LQN|ExKM7:TR?= Mk\VO|IhcA>? NGjJcYNFVVOR MmCxTWM2OD1zMDFOwG0> NGnGc|EzOzh2NECzPC=>
Raji NHHM[INIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHH[XYyOCEQvF2= NWX6[3NnPzJiaB?= NH;WTnpFVVOR M{PYPGlEPTB;MUCg{txO NWnqO3BrOjN6NESwN|g>
RD MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXFSoUyOCEQvF2= MoK3O|IhcA>? NHzKNW5FVVOR NVnjSZJxUUN3ME2xNEDPxE1? MlTWNlM5PDRyM{i=
RD-ES M{fD[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3jcIkyOCEQvF2= MV63NkBp MmGzSG1UVw>? MXrJR|UxRTFyIN88US=> Ml7mNlM5PDRyM{i=
RL NV[xbIRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojvNVAh|ryP MVG3NkBp NYj6Nmx1TE2VTx?= MX7JR|UxRTFyIN88US=> MWqyN|g1PDB|OB?=
SaOS2 MkjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYWxNEDPxE1? MkXvO|IhcA>? MYTEUXNQ MXTJR|UxRTFyIN88US=> M1nOdlI{QDR2MEO4
SCC-9 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLPNVAh|ryP MofwO|IhcA>? NF3ReXdFVVOR M3qzOWlEPTB;MUCg{txO NVjsToRQOjN6NESwN|g>
SCC-12 NWnuSWVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDrNVAh|ryP MYS3NkBp MVHEUXNQ NUDBXpJVUUN3ME2xNEDPxE1? M3;kc|I{QDR2MEO4
SCC-13 MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mln4NVAh|ryP NXzTSphnPzJiaB?= NGT2fppFVVOR MW\JR|UxRTFyIN88US=> MoD0NlM5PDRyM{i=
SCC-15 NW\LWll7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW[xNEDPxE1? MWW3NkBp NYTEeWwzTE2VTx?= MUPJR|UxRTFyIN88US=> MX6yN|g1PDB|OB?=
SCC-25 M{HMNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkK1NVAh|ryP MnK4O|IhcA>? NIXmboFFVVOR NFWw[oRKSzVyPUGwJO69VQ>? M2DWdlI{QDR2MEO4
SCLC-3 NHuxR3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWGxNEDPxE1? MV63NkBp M4HCcmROW09? MXrJR|UxRTFyIN88US=> M1PHZlI{QDR2MEO4
SF-268 NHjUdlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHQ[pN3OTBizszN NHfpZ2E4OiCq MUTEUXNQ M4fFfmlEPTB;MUCg{txO NEm2eY4zOzh2NECzPC=>
SF-295 NHzCcVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nadlExKM7:TR?= NGLOb|g4OiCq MVrEUXNQ NH\zelZKSzVyPUGwJO69VQ>? M4\2NlI{QDR2MEO4
SJRH30 M37LXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\iZmgyOCEQvF2= MYG3NkBp NXnLeIxMTE2VTx?= MVjJR|UxRTFyIN88US=> MUeyN|g1PDB|OB?=
SK-BR-3 NFLZPIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;xb|ExKM7:TR?= Mn74O|IhcA>? NXHoTIV2TE2VTx?= M3ryXWlEPTB;MUCg{txO NVLadm1EOjN6NESwN|g>
SK-LMS-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXW4SHZlOTBizszN NWDWco1IPzJiaB?= NWfvToRKTE2VTx?= MUPJR|UxRTFyIN88US=> MlLvNlM5PDRyM{i=
SK-N-DZ MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYexNEDPxE1? MYm3NkBp MlixSG1UVw>? NU\X[oZVUUN3ME2xNEDPxE1? MoTmNlM5PDRyM{i=
SK-N-F1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDnNVAh|ryP Mmm1O|IhcA>? MX7EUXNQ M1P0RmlEPTB;MUCg{txO NHXFWGIzOzh2NECzPC=>
SKOV-3 NIDQfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXGxNEDPxE1? MWG3NkBp MmLjSG1UVw>? NX\2XXlZUUN3ME2xNEDPxE1? M{TORlI{QDR2MEO4
SK-UT-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWmxNEDPxE1? MnS4O|IhcA>? NH2zZ4hFVVOR MWDJR|UxRTFyIN88US=> Mk\FNlM5PDRyM{i=
SN12C NYn0ToZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jtZlExKM7:TR?= MV[3NkBp MYHEUXNQ NWXyZZFoUUN3ME2xNEDPxE1? MYOyN|g1PDB|OB?=
SNB-19 MljFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETBflUyOCEQvF2= MlXuO|IhcA>? MljDSG1UVw>? Mm\2TWM2OD1zMDFOwG0> M3jITlI{QDR2MEO4
SNU-5 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVqxNEDPxE1? MVW3NkBp MnnGSG1UVw>? NVfuR2FsUUN3ME2xNEDPxE1? M{naflI{QDR2MEO4
SNU-16 M4DUSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIKyXowyOCEQvF2= NVPKUJJGPzJiaB?= MXXEUXNQ NWThT2o3UUN3ME2xNEDPxE1? Ml7aNlM5PDRyM{i=
SNU-398 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnT5NVAh|ryP MmrpO|IhcA>? Mn;4SG1UVw>? MWfJR|UxRTFyIN88US=> NH;KVHIzOzh2NECzPC=>
SNU-449 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV6xNEDPxE1? MorSO|IhcA>? M2nLU2ROW09? NILzfohKSzVyPUGwJO69VQ>? NEnsXo0zOzh2NECzPC=>
SR M2OxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTCWXF{OTBizszN NX\FU5dUPzJiaB?= MULEUXNQ NGHCZo5KSzVyPUGwJO69VQ>? MnXaNlM5PDRyM{i=
ST486 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWmxNEDPxE1? MmjsO|IhcA>? M{fPVGROW09? MYHJR|UxRTFyIN88US=> NIPXdnEzOzh2NECzPC=>
SW579 NF72SYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX2xNEDPxE1? NGjpSZA4OiCq M1TsW2ROW09? NU[4eYZ5UUN3ME2xNEDPxE1? MkHSNlM5PDRyM{i=
SW684 M2nCXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33HSlExKM7:TR?= MmrVO|IhcA>? NVLVdohETE2VTx?= NID0SmZKSzVyPUGwJO69VQ>? NGDk[4gzOzh2NECzPC=>
SW-780 NG\6[2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXKxNEDPxE1? MnzKO|IhcA>? MYTEUXNQ MUHJR|UxRTFyIN88US=> NHfCcnMzOzh2NECzPC=>
SW900 M2HPSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTGXXFOOTBizszN M3;2[FczKGh? MoWxSG1UVw>? MV\JR|UxRTFyIN88US=> MYGyN|g1PDB|OB?=
SW1088 M{O5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUixNEDPxE1? MWW3NkBp MnrvSG1UVw>? NUnheFBkUUN3ME2xNEDPxE1? NIC4TJUzOzh2NECzPC=>
SW1463 M2O5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjTZ2kyOCEQvF2= NHnU[5A4OiCq M1rjbGROW09? Mmf1TWM2OD1zMDFOwG0> MVOyN|g1PDB|OB?=
SW1990 M1LBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVGxNEDPxE1? MVG3NkBp MoTuSG1UVw>? MVHJR|UxRTFyIN88US=> NU\oTmJJOjN6NESwN|g>
T47D M2jsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXKxNEDPxE1? MVe3NkBp M4jXSmROW09? M2DScmlEPTB;MUCg{txO M4C3XlI{QDR2MEO4
TE381.T M4LUN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUexNEDPxE1? NWrKWZE4PzJiaB?= NE[3OpBFVVOR MoPZTWM2OD1zMDFOwG0> NH3lZpQzOzh2NECzPC=>
TK-10 MmfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVSxNEDPxE1? MnHrO|IhcA>? NWDHd4hLTE2VTx?= NUHVNGpGUUN3ME2xNEDPxE1? NWjHcG5COjN6NESwN|g>
U2OS NHjXV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HQNVExKM7:TR?= MVi3NkBp MnLkSG1UVw>? NFTZfYhKSzVyPUGwJO69VQ>? MlvNNlM5PDRyM{i=
U251 M3vWXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHX5e3oyOCEQvF2= MVy3NkBp MWnEUXNQ NVXXO5pOUUN3ME2xNEDPxE1? MXKyN|g1PDB|OB?=
UACC-812 NEfFSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X2TFExKM7:TR?= M1P6UFczKGh? NV\WRlByTE2VTx?= MWrJR|UxRTFyIN88US=> MYOyN|g1PDB|OB?=
YAPC NFK0W4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTZNVAh|ryP MU[3NkBp MknuSG1UVw>? M2XEPWlEPTB;MUCg{txO NFvTN4ozOzh2NECzPC=>
ZR-75-1 NX7QcJNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\YUG9qOTBizszN NWPuZYFqPzJiaB?= M3jZXmROW09? M2DNemlEPTB;MUCg{txO NISzdWEzOzh2NECzPC=>
A375 NXPYfopXTnWwY4Tpc44h[XO|YYm= MnHXNU4zKM7:TR?= MkT1OEBp NFnFUo5FVVOR NFnyO2xKdmirYnn0bY9vKG:oIIDoc5NxcG:{eXzheIlwdiCxZjDNSWstKEWUSzygZY5lKFN4UB?= NHrIZY0zOjN6OUS3NS=>
YUSIT1 MWDGeY5kfGmxbjDhd5NigQ>? NFy2XpBFVVOR NGnTRnZz\WS3Y3XkJJNmdnOrdHn2bZR6KHerdHigTWM2OCB-IECuOUDPxE1? M2S3S|IzOzh7NEex
MeWo MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYHEUXNQ MVrJR|UxKD1iOUi3JI5O MXmyOlAyQDV{NB?=
WiDr NY\rTWpzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M165d2ROW09? NX3XTWFSUUN3MDC9JFc3KG6P M{jxelI3ODF6NUK0
Colo-205 MWjGeY5kfGmxbjDhd5NigQ>? NF3aV4IyKM7:TR?= NV\DeItkPCCm MXnEUXNQ MXzJcoR2[2WmIHGgbIlocGy7IHPvcZBiemGkbHWgZ49ueGGldHnvckBxcGWwb4T5dIU> NFnaWWszPTN6MUG1Ni=>
RBW-1 NX7NRZdjTnWwY4Tpc44h[XO|YYm= M1;OO|Eh|ryP M4Ox[mROW09? MnjvUo8hemWmdXP0bY9vKG:oIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v NInrWVUzPDh6NU[5NC=>
RBO-1 NHOyTFFHfW6ldHnvckBie3OjeR?= NWfI[YcyOSEQvF2= M3HEN2ROW09? MVrJcohq[mm2aX;uJI9nKE2nazCxM|IheGixc4Doc5J6dGG2aX;u MYqyOFg5PTZ7MB?=
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M257 NH3pOYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnod|h7OTByIH7N NH\RUpQ4OiCq M{TrUmRw\XNibn;0JIlvcGmkaYSgdJJwdGmoZYLheIlwdiCxZjDNNlU4KGOnbHygbIFz[m:3cnnu[{B4cWymIIT5dIUhSlKDRh?= MYeyN|MyPzR2Nh?=
LCP NV;GVZdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:xNFAhdk1? NGDNcm04OiCq MlH4TY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;uJI9nKEyFUDDj[YxtKGijcnLveZJqdmdiQmLBSkBXPjByUjDteZRidnSjdHnvci=> NXTtb2lVOjN|MUe0OFY>
WM266 MorKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXid3cyODBibl2= NHfiUG84OiCq NF[3RoJKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiV12yOlYh[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNWQhdXW2YX70ZZRqd25? MmHqNlM{OTd2NE[=
M257 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3RNVAxKG6P MlztO|IhcA>? MnXXSI9meyCwb4SgbY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIF2yOVch[2WubDDoZZJjd3W{aX7nJJdqdGRidInw[UBDWkGI MmPKNlM{OTd2NE[=
LCP MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV6xNFAhdk1? NH;iSFc4OiCq MmXnTY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIFzDVEBk\WyuIHjhdoJwfXKrbnegRnJCTiCYNkCwVkBufXSjboTheIlwdg>? MmfKNlM{OTd2NE[=
WM266 NFz3W|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmi2NVAxKG6P NXPRZm1[PzJiaB?= MnzvTY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIGfNNlY3KGOnbHygbIFz[m:3cnnu[{BDWkGIIG[2NFBFKG23dHHueIF1cW:w MlfLNlM{OTd2NE[=

... Click to View More Cell Line Experimental Data

体内研究 Dabrafenib(口服)抑制B-RafV600E突变的黑色素瘤(A375P)的生长,在免疫受损小鼠中皮下注射结肠癌(Colo205),Dabrafenib(口服)同样能抑制肿瘤生长。 [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
30% PEG400+0.5% Tween80+5% propylene glycol
8 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 519.56
化学式

C23H20F3N5O2S2

CAS号 1195765-45-7
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01723202 Active, not recruiting Follicular Thyroid Cancer|Insular Thyroid Cancer|Papillary Thyroid Cancer|Recurrent Thyroid Cancer Manisha Shah|National Comprehensive Cancer Network|Ohio State University Comprehensive Cancer Center November 7, 2012 Phase 2
NCT02672358 Not yet recruiting Non-Small-Cell Lung Cancer Novartis Pharmaceuticals|Novartis October 2017 Phase 2
NCT02447939 Withdrawn Melanoma GlaxoSmithKline May 2017 Phase 1
NCT02967692 Not yet recruiting Melanoma Novartis Pharmaceuticals|Novartis February 2017 Phase 3
NCT02858921 Not yet recruiting Melanoma Melanoma Institute Australia|Merck Sharp & Dohme Corp.|Novartis February 2017 Phase 2
NCT03026517 Recruiting Melanoma Memorial Sloan Kettering Cancer Center|Massachusetts General Hospital|Weill Medical College of Cornell University January 2017 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Raf Signaling Pathway Map

Raf Inhibitors with Unique Features

相关Raf产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID