Tauroursodeoxycholic Acid (TUDCA)
中文名称：牛磺熊去氧胆酸
Tauroursodeoxycholic acid (TUDCA)是乌索脱氧胆酸的牛磺酸共轭产物，在多种神经退行性疾病，如阿尔茨海默病、帕金森疾病和亨廷顿疾病中，可作为线粒体稳定剂和抗凋亡试剂。
Tauroursodeoxycholic Acid (TUDCA) Chemical Structure
CAS: 14605-22-2
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产品质控
Tauroursodeoxycholic Acid (TUDCA)相关产品
Apoptosis related抑制剂选择性比较
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| HuH7 | Cytoprotective assay | 1 mM | 24 hrs | Cytoprotective activity against DCA-induced cell death in human HuH7 cells assessed as increase in cell viability at 1 mM preincubated with cells followed by DCA addition measured after 24 hrs by MTT/INCELL assay | 27729186 |
| HEK293 | Function assay | 90 mins | Inhibition of human ATX expressed in HEK293 Flp-In cells assessed as decrease in choline release from LPC measured every 30 secs for 90 mins by HVA based fluorescence assay, IC50=10.3μM | 28165241 | |
| HuH7 | Cytoprotective assay | 6 hrs | Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as inhibition of CHOP mRNA levels after 6 hrs | 27729186 | |
| HuH7 | Cytoprotective assay | 6 hrs | Cytoprotective activity against DCA-induced ER stress in human HuH7 cells assessed as increase in XBPu mRNA levels after 6 hrs | 27729186 | |
| HuH7 | Cytoprotective assay | 6 hrs | Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as increase in XBPu mRNA levels after 6 hrs | 27729186 | |
| HuH7 | Cytoprotective assay | 6 hrs | Cytoprotective activity against DCA-induced ER stress in human HuH7 cells assessed as inhibition of XBPs mRNA levels after 6 hrs | 27729186 | |
| HuH7 | Cytoprotective assay | 6 hrs | Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as inhibition of XBPs mRNA levels after 6 hrs | 27729186 | |
| HuH7 | Cytoprotective assay | 6 hrs | Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as reduction in XBPs/XBPu ratio after 6 hrs | 27729186 | |
| HuH7 | Cytoprotective assay | 6 hrs | Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as inhibition of BIP/GRP78 mRNA levels after 6 hrs | 27729186 | |
| CHO cells | Function assay | Agonist activity at human TGR5 expressed in CHO cells by luciferase assay, EC50=30 μM | 18307294 | ||
| Sf9 | Function assay | TP_TRANSPORTER: uptake in membrane vesicles from Bsep-expressing Sf9 cells, Km=4.1μM | 10648470 | ||
| MDCK | Function assay | TP_TRANSPORTER: uptake in Oatp3-expressing MDCK cells, Km=6.6μM | 11093941 | ||
| Sf9 | Function assay | TP_TRANSPORTER: uptake in membrane vesicles isolated from Bsep-expressing Sf9 cells, Km=11.9μM | 12404240 | ||
| CHO | Function assay | TP_TRANSPORTER: uptake in Ntcp-expressing CHO cells, Km=14μM | 9486191 | ||
| COS | Function assay | TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cells, Ki=28μM | 9458785 | ||
| HEK293 | Function assay | Non-competitive inhibition of human ATX expressed in HEK293 Flp-In cells assessed as decrease in LPC hydrolysis by Lineweaver-Burk plot analysis | 28165241 | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Tauroursodeoxycholic acid (TUDCA)是乌索脱氧胆酸的牛磺酸共轭产物，在多种神经退行性疾病，如阿尔茨海默病、帕金森疾病和亨廷顿疾病中，可作为线粒体稳定剂和抗凋亡试剂。 |
|---|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05753852 | Recruiting | Amyotrophic Lateral Sclerosis |
Humanitas Mirasole SpA|University of Ulm|University of Sheffield|University Hospital Tours|KU Leuven|UMC Utrecht|University of Dublin Trinity College|Bruschettini S.r.l.|Istituto Superiore di Sanità|Motor Neurone Disease Association |
October 25 2021 | Phase 3 |
| NCT04114292 | Unknown status | Ulcerative Colitis |
Washington University School of Medicine|Crohn''s and Colitis Foundation |
January 17 2019 | Phase 1 |
| NCT01899703 | Completed | Cholestasis Intrahepatic |
GlaxoSmithKline |
March 10 2014 | Phase 2 |
化学信息&溶解度
| 分子量 | 499.70 | 分子式 | C26H45NO6S |
| CAS号 | 14605-22-2 | SDF | Download Tauroursodeoxycholic Acid (TUDCA) SDF |
| Smiles | CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C | ||
| 储存条件(自收到货起) | |||
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体外溶解度 |
DMSO : 100 mg/mL ( (200.12 mM)； DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Water : 100 mg/mL Ethanol : 50 mg/mL |
摩尔浓度计算器 |
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体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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