Torin 1

目录号:S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。

规格 价格 库存 购买数量  
RMB 1419.84 现货
RMB 3019.04 现货
RMB 5492.28 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用该产品的4个实验数据:

  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

产品安全说明书

mTOR抑制剂选择性比较

生物活性

产品描述 Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。
靶点
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
体外研究

Torin1在2和10 nM浓度下分别抑制mTORC1 和mTORC2底物的磷酸化。此外,Torin1对mTOR比对PI3K (EC50 = 1800 nM)的选择性高1000倍,比对450种其它蛋白激酶的结合选择性高100倍。[1] [2] Torin1通过耐rapamycin机制引起细胞周期阻滞,并且其不依赖于mTORC2。Torin1比rapamycin更完全地干扰mTORC1依赖表现型。Cap依赖性翻译需要mTORC1耐Rapamycin的功能。[1]在近期的一项研究中,据报道Torin1通过活化人内分泌细胞系BON 中MEK/ERK/c-Jun通路,能够增加神经降压素分泌和基因表达。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\wWWlGUUN3ME2wMlAxODNyNjFOwG0> NVriNIo3W0GQR1XS
OCUB-M NWXwWmxXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPMTWM2OD1yLkCwNVk1KM7:TR?= MUnTRW5ITVJ?
DOHH-2 Ml\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vqWmlEPTB;MD6wNFIzPSEQvF2= M{LJZ3NCVkeHUh?=
NOS-1 Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVi5Vpk3UUN3ME2wMlAxOjR{IN88US=> NFvT[IZUSU6JRWK=
L-363 M1PISmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXW0V4NoUUN3ME2wMlAxOjh2IN88US=> NXyyNlNxW0GQR1XS
RL95-2 M1rhT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj5TYRKSzVyPUCuNFA{OiEQvF2= NVXvWJpVW0GQR1XS
BL-70 M1LoXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMECzN|ch|ryP NV;pWZZzW0GQR1XS
TGBC1TKB NGLaOWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\iTWM2OD1yLkCwN|c6KM7:TR?= NGj5XVlUSU6JRWK=
697 NFuyV2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMEC2N|Qh|ryP NYHHNpg3W0GQR1XS
RPMI-8226 NFO5ZmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PES2lEPTB;MD6wNFY2OSEQvF2= NHPHc5FUSU6JRWK=
BL-41 NWqxcmh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;yTVVtUUN3ME2wMlAxPjl4IN88US=> MWDTRW5ITVJ?
MRK-nu-1 MnfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDU[llmUUN3ME2wMlAxPzB5IN88US=> MVPTRW5ITVJ?
EW-1 M3vZdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;DTWM2OD1yLkCwO|Q6KM7:TR?= NETacJBUSU6JRWK=
EVSA-T NYX5VFd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMEC4PVIh|ryP M1PPT3NCVkeHUh?=
HUTU-80 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX0Z5ZKSzVyPUCuNFA6OjlizszN NI\PTnpUSU6JRWK=
VA-ES-BJ MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;GTWM2OD1yLkCwPVg1KM7:TR?= MXzTRW5ITVJ?
GCIY MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rPWmlEPTB;MD6wNVAxPyEQvF2= NITTNWhUSU6JRWK=
ES6 M4qz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTjW41KSzVyPUCuNFExQDNizszN Moi5V2FPT0WU
NALM-6 M1O4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HxVWlEPTB;MD6wNVExOiEQvF2= MoqxV2FPT0WU
LB996-RCC NHftTIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3WSYtKSzVyPUCuNFEyOzdizszN MlnBV2FPT0WU
EW-16 M16zUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XtZWlEPTB;MD6wNVE6OiEQvF2= MVHTRW5ITVJ?
KALS-1 NGPJWZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInWRVdKSzVyPUCuNFEyQThizszN MmDsV2FPT0WU
OPM-2 NHvzU2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\K[GlEPTB;MD6wNVI6KM7:TR?= NIjiPXBUSU6JRWK=
KU812 MnvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLtN4dzUUN3ME2wMlAyOjl4IN88US=> M{PySHNCVkeHUh?=
A4-Fuk NYP2d4JDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEGzNVkh|ryP NHLoRplUSU6JRWK=
KGN NYe5NJJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMEGzOVkh|ryP NXjUWHg5W0GQR1XS
KS-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\OTWM2OD1yLkCxN|kzKM7:TR?= MWPTRW5ITVJ?
no-11 NXLXd3hkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7ETWM2OD1yLkCxN|k2KM7:TR?= NG\ifmhUSU6JRWK=
PSN1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH5XG5NUUN3ME2wMlAyPDB7IN88US=> MV;TRW5ITVJ?
SK-LMS-1 M1LVfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEG0NVMh|ryP NFvlbIVUSU6JRWK=
LS-411N NGDBclZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXThfWFEUUN3ME2wMlAyPDN7IN88US=> Mn6yV2FPT0WU
HT-144 M4fJN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr2TmZGUUN3ME2wMlAyPDVzIN88US=> NX7kOIQxW0GQR1XS
ACN MlzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMEG1JO69VQ>? NIHvXpJUSU6JRWK=
RKO MoHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDuVoFKSzVyPUCuNFE2OzNizszN MYPTRW5ITVJ?
CMK NWP3[4lUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PRdGlEPTB;MD6wNVU1OyEQvF2= MVzTRW5ITVJ?
GB-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHsepNEUUN3ME2wMlAyPTV|IN88US=> Ml[4V2FPT0WU
KE-37 MkT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTIVY9ZUUN3ME2wMlAyPTd|IN88US=> MUHTRW5ITVJ?
no-10 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3TTWM2OD1yLkCxOVg1KM7:TR?= Mn3GV2FPT0WU
MOLT-16 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfZUVNKSzVyPUCuNFE3OjJizszN NFrteo1USU6JRWK=
HEL NFXHfXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXF[ZNZUUN3ME2wMlAyPjRizszN M1KybnNCVkeHUh?=
NCI-H1355 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fC[GlEPTB;MD6wNVY1PiEQvF2= M1j5XnNCVkeHUh?=
IST-MEL1 MnrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEG3O|Qh|ryP M1KzR3NCVkeHUh?=
MHH-PREB-1 M1\JZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMEG4NVgh|ryP Ml;vV2FPT0WU
ES8 NFjLVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\pS5VKSzVyPUCuNFE5PDRizszN MkjGV2FPT0WU
LC-2-ad MmXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD2cJdRUUN3ME2wMlAzOTN5IN88US=> MnPkV2FPT0WU
LAMA-84 NEPscZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W5XGlEPTB;MD6wNlE3PyEQvF2= MUDTRW5ITVJ?
BV-173 NF;XSVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;OTWM2OD1yLkCyNlA{KM7:TR?= NG\SSGVUSU6JRWK=
SW872 M36yZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3MSVNQUUN3ME2wMlAzOjR5IN88US=> NYn0XWpLW0GQR1XS
SK-UT-1 NVXLSHJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHVTWM2OD1yLkCyNlYyKM7:TR?= NUH6[nVRW0GQR1XS
OS-RC-2 NWO4U4VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjNNWcyUUN3ME2wMlAzOzJ|IN88US=> NVnUZXg4W0GQR1XS
NCI-H747 MoP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfSfWl5UUN3ME2wMlAzOzNizszN MWjTRW5ITVJ?
MZ2-MEL MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX70UIZYUUN3ME2wMlAzOzN5IN88US=> NH3TPZlUSU6JRWK=
TE-11 NUL4SnVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEKzO|Ih|ryP MkjNV2FPT0WU
KURAMOCHI NWDBZ2RYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\TSGlEPTB;MD6wNlQyPCEQvF2= NX\pOXZoW0GQR1XS
HD-MY-Z Mke4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jEXGlEPTB;MD6wNlQzPiEQvF2= M2TOZ3NCVkeHUh?=
GI-1 NWf0WFBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\STWM2OD1yLkCyOFY6KM7:TR?= NEXyeVFUSU6JRWK=
LB1047-RCC M2nSWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7lTWM2OD1yLkCyOFg5KM7:TR?= MUjTRW5ITVJ?
TE-12 MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMEK1OUDPxE1? NUjwTW9HW0GQR1XS
MZ7-mel M4HaXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXGWlM5UUN3ME2wMlAzPjB7IN88US=> MlvlV2FPT0WU
MMAC-SF M{DURWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny2TWM2OD1yLkCyOlM{KM7:TR?= NXntPHhPW0GQR1XS
A101D MmDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\XZWlEPTB;MD6wNlY2KM7:TR?= NGC3VW9USU6JRWK=
GR-ST NGjVbXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj6TWM2OD1yLkCyOlU2KM7:TR?= NGLsNJhUSU6JRWK=
MC116 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMEK2PEDPxE1? M2S4eXNCVkeHUh?=
Ramos-2G6-4C10 NXzQbW5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\CXWlEPTB;MD6wNlc2KM7:TR?= NUDabXFpW0GQR1XS
ATN-1 MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMEK3PFkh|ryP M1HxfHNCVkeHUh?=
MFH-ino M1TzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXUeGVKSzVyPUCuNFI5OTJizszN M2ToPHNCVkeHUh?=
DEL MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMEK4NVUh|ryP NUXMSJVuW0GQR1XS
OCI-AML2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLsV3R{UUN3ME2wMlAzQDdzIN88US=> MVLTRW5ITVJ?
LXF-289 NHe1U5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPZfHQ{UUN3ME2wMlAzQDd{IN88US=> MkjPV2FPT0WU
IA-LM M1;FfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;XTWM2OD1yLkCyPVE4KM7:TR?= M3uwTXNCVkeHUh?=
EoL-1-cell M1HZdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEK5PVYh|ryP NEHyclFUSU6JRWK=
OVCAR-4 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEOwPVQh|ryP M{Sw[XNCVkeHUh?=
ES1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3kOpNNUUN3ME2wMlA{ODl5IN88US=> NEjNWYpUSU6JRWK=
CESS NGrMRlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTyTWM2OD1yLkCzNFk6KM7:TR?= MoHTV2FPT0WU
GAK NVLVT4w5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEOxPFYh|ryP NET6THhUSU6JRWK=
NTERA-S-cl-D1 NEPHe5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3VZYttUUN3ME2wMlA{OjJ4IN88US=> M{\qfXNCVkeHUh?=
TE-10 M{m3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMEOzNVEh|ryP M2TveHNCVkeHUh?=
CCRF-CEM MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvzVYViUUN3ME2wMlA{OzdzIN88US=> NYT4SlBtW0GQR1XS
NMC-G1 M{jDVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP2NJlKSzVyPUCuNFM1PDhizszN MnX5V2FPT0WU
HOP-62 Ml3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWr1RVh3UUN3ME2wMlA{PTV4IN88US=> M2TPO3NCVkeHUh?=
SH-4 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHrPJJKSzVyPUCuNFM2QDJizszN MV3TRW5ITVJ?
NCI-H1648 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEezUGNKSzVyPUCuNFM3OjJizszN M{myTXNCVkeHUh?=
EB-3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEO2OFMh|ryP MWLTRW5ITVJ?
BB65-RCC NX\SSG0yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEP2dYRKSzVyPUCuNFM3QTFizszN NVXU[lFUW0GQR1XS
BE-13 NEPMNIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TwZWlEPTB;MD6wN|c2QSEQvF2= NXL0e3BuW0GQR1XS
CP67-MEL M4mxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[5VVZ{UUN3ME2wMlA{PzV7IN88US=> NYO1bVYzW0GQR1XS
SW954 NF7D[XRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMEO3PUDPxE1? MUTTRW5ITVJ?
TE-5 M2P5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fXbGlEPTB;MD6wN|g2PCEQvF2= NWKxe4xyW0GQR1XS
HCE-4 NVzifVhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjoUXFTUUN3ME2wMlA{QDV3IN88US=> NGXJWZpUSU6JRWK=
LC-1F MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mon5TWM2OD1yLkCzPVg6KM7:TR?= MoHjV2FPT0WU
TK10 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC0TI5PUUN3ME2wMlA1ODF7IN88US=> NUOzfI9[W0GQR1XS
SJSA-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\Zd21ZUUN3ME2wMlA1OTh6IN88US=> MmXpV2FPT0WU
Daudi NHjzR5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMESyNlUh|ryP MUnTRW5ITVJ?
SW982 M{TDU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnT6TWM2OD1yLkC0NlQ3KM7:TR?= MkOyV2FPT0WU
SF126 NY\Rb2x1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moj2TWM2OD1yLkC0N|YyKM7:TR?= NXfiOldpW0GQR1XS
TE-15 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWO4N45MUUN3ME2wMlA1PDN3IN88US=> NVnKWJU5W0GQR1XS
COLO-684 NGniT29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fPdmlEPTB;MD6wOFU3OSEQvF2= MYrTRW5ITVJ?
8-MG-BA Mkm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;sTWM2OD1yLkC0OlI6KM7:TR?= MkPQV2FPT0WU
NB13 NIXlWYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXpSmJKSzVyPUCuNFQ4PzZizszN M17JUnNCVkeHUh?=
HCC1599 NX64XFYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzXTWM2OD1yLkC0PFc6KM7:TR?= MkDXV2FPT0WU
SK-PN-DW MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;acnFKSzVyPUCuNFQ6PDlizszN M1LHc3NCVkeHUh?=
ALL-PO NWjrco04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDHVZE5UUN3ME2wMlA1QTV4IN88US=> NH7MSXVUSU6JRWK=
NB6 NFPnTIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfiTWNKSzVyPUCuNFUzPzFizszN MUjTRW5ITVJ?
IST-SL2 NYPFbmppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnReohmUUN3ME2wMlA2OzZ{IN88US=> MXHTRW5ITVJ?
BB30-HNC NIn0fGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjwbmNKSzVyPUCuNFU4OyEQvF2= NUPiRVNWW0GQR1XS
SW962 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEToNZNKSzVyPUCuNFU4PjNizszN NVvSNVVZW0GQR1XS
TGBC24TKB MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnFbFBKSzVyPUCuNFU4QTlizszN NFHYWHZUSU6JRWK=
KINGS-1 NVLrcY1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXDTWM2OD1yLkC1PFA{KM7:TR?= MYTTRW5ITVJ?
HC-1 NEnMR3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITLUWhKSzVyPUCuNFU5OjdizszN MmHYV2FPT0WU
RS4-11 MmjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLQTWM2OD1yLkC1PVM5KM7:TR?= M1PIVHNCVkeHUh?=
LS-123 NHvKS|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXOTIluUUN3ME2wMlA2QTR{IN88US=> M4TaOHNCVkeHUh?=
A3-KAW MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XIV2lEPTB;MD6wOlIzPSEQvF2= MWnTRW5ITVJ?
SNB75 NWfmbFJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jYdWlEPTB;MD6wOlM1OSEQvF2= NU\ifVhNW0GQR1XS
SR NEHBZ4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwME[zO|Qh|ryP NHK5fXZUSU6JRWK=
LOUCY NXLKRXNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fSdmlEPTB;MD6wOlM6PCEQvF2= M4jqV3NCVkeHUh?=
K5 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLnTWM2OD1yLkC2OFA{KM7:TR?= NUP3eXZsW0GQR1XS
Becker M1TH[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwME[0NkDPxE1? MYPTRW5ITVJ?
CTV-1 M2\5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzQXVBKSzVyPUCuNFY2PDhizszN NXv5VWFnW0GQR1XS
KLE NYLvb|RWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwME[1PFQh|ryP Ml3SV2FPT0WU
MZ1-PC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF:yNGdKSzVyPUCuNFY2QThizszN NWizNVlCW0GQR1XS
MOLT-4 MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3n6cWlEPTB;MD6wOlYxPSEQvF2= MkHCV2FPT0WU
MLMA NXjyfIw4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPCXWhqUUN3ME2wMlA3PzhizszN Ml\uV2FPT0WU
A388 M1rndGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIqydodKSzVyPUCuNFY5QTNizszN NHPzcpNUSU6JRWK=
MV-4-11 NF\vbG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DhdGlEPTB;MD6wOlk6PSEQvF2= NIDOZ3pUSU6JRWK=
DSH1 Mmj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HXW2lEPTB;MD6wO|E4OyEQvF2= NEW5[XFUSU6JRWK=
MONO-MAC-6 MkjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n1UmlEPTB;MD6wO|IyOiEQvF2= M1LKW3NCVkeHUh?=
ARH-77 NHO0VpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXiZ2g4UUN3ME2wMlA4Ojd6IN88US=> Mn\RV2FPT0WU
LB771-HNC NELybnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LabWlEPTB;MD6wO|U1QSEQvF2= M4XxdnNCVkeHUh?=
PF-382 NEexW4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFz1RlRKSzVyPUCuNFc2PjlizszN MYfTRW5ITVJ?
KM12 NETCOHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTjTWM2OD1yLkC3OlQh|ryP M2\a[nNCVkeHUh?=
HAL-01 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTYTWM2OD1yLkC3OlU5KM7:TR?= MnjyV2FPT0WU
RPMI-8402 NWraXZJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XzO2lEPTB;MD6wO|c5QSEQvF2= NXTzTJhqW0GQR1XS
OMC-1 NWjFOlFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Tpb2lEPTB;MD6wO|gxPCEQvF2= MnfJV2FPT0WU
HT NIf4R25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPN[5dKSzVyPUCuNFgh|ryP NETR[FNUSU6JRWK=
QIMR-WIL NVnkfHdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHhTVRKSzVyPUCuNFgxPTVizszN M2TkTHNCVkeHUh?=
KNS-42 NYLyW4QyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEiyNFMh|ryP NIGwe|NUSU6JRWK=
BC-3 Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PEUWlEPTB;MD6wPFIxPCEQvF2= M3O5dHNCVkeHUh?=
ES4 NFHPOGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPrTWM2OD1yLkC4Nlk3KM7:TR?= MXnTRW5ITVJ?
NCI-H23 NHfERYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXmZWR[UUN3ME2wMlA5PDRizszN Mm\3V2FPT0WU
LB2518-MEL MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMEi2PVYh|ryP NXnzRoxMW0GQR1XS
LC4-1 M1TTfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknOTWM2OD1yLkC4O|M5KM7:TR?= MXXTRW5ITVJ?
SIG-M5 NV60TXVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\WXnZbUUN3ME2wMlA5QTB2IN88US=> NHrMWG9USU6JRWK=
LP-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Xne2lEPTB;MD6wPFk{QCEQvF2= M4\ae3NCVkeHUh?=
TE-8 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVe5dmZIUUN3ME2wMlA6ODF4IN88US=> MlK3V2FPT0WU
K-562 NELtOWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmC4TWM2OD1yLkC5NVIh|ryP MnjvV2FPT0WU
J-RT3-T3-5 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XoS2lEPTB;MD6wPVE2OyEQvF2= M4PHOXNCVkeHUh?=
DU-4475 M3jaR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L0W2lEPTB;MD6wPVE3PSEQvF2= NHfENXFUSU6JRWK=
RXF393 NVLjdHM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvOVVdXUUN3ME2wMlA6PDZ{IN88US=> NFrYb5FUSU6JRWK=
NB5 M3HQb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLyTWM2OD1yLkC5OlI2KM7:TR?= MYTTRW5ITVJ?
A704 NWfxfXlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMEm3OFEh|ryP MU\TRW5ITVJ?
SF268 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEm4NlUh|ryP NH7mZ2hUSU6JRWK=
UACC-257 NH[wN4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zTcWlEPTB;MD6wPVg{OyEQvF2= M3SxRnNCVkeHUh?=
L-428 M2LGZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq4WHJKSzVyPUCuNVA{OiEQvF2= M2nKcHNCVkeHUh?=
ST486 MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHq4VmlKSzVyPUCuNVA3ODZizszN MWHTRW5ITVJ?
SK-MM-2 NYHhd3A{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3PTWM2OD1yLkGwO|A6KM7:TR?= NV\PSnJZW0GQR1XS
COR-L279 NUjU[ppyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3S[pZKSzVyPUCuNVA5OzJizszN M3mw[HNCVkeHUh?=
JiyoyeP-2003 NHPlcldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDlR3ZKSzVyPUCuNVA5PDNizszN Ml[3V2FPT0WU
GT3TKB NF63do1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3WRoJKSzVyPUCuNVA6OThizszN NVTCOlhCW0GQR1XS
HCE-T NGPHNoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r0RmlEPTB;MD6xNFk1KM7:TR?= NUTPS5VZW0GQR1XS
SBC-1 NXfTSGVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3SXYtMUUN3ME2wMlEyOTF7IN88US=> NFvPN5JUSU6JRWK=
KNS-81-FD MlP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMUGyO|Mh|ryP NH7sdpdUSU6JRWK=
NCI-H2126 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33nbmlEPTB;MD6xNVM6PCEQvF2= MWDTRW5ITVJ?
EM-2 NFLCWXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMUG1Nlkh|ryP MmfrV2FPT0WU
JAR MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nEWmlEPTB;MD6xNVU6QCEQvF2= NVHORZBTW0GQR1XS
NB17 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:2UWlEPTB;MD6xNVY2OiEQvF2= M4PGVnNCVkeHUh?=
LB647-SCLC NXSxUlhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fre2lEPTB;MD6xNVcxPSEQvF2= MXLTRW5ITVJ?
CAL-148 NFPPRYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMUG4JO69VQ>? MUnTRW5ITVJ?
K052 NWTmPVlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm3VHlWUUN3ME2wMlEyQDVzIN88US=> M131SHNCVkeHUh?=
KARPAS-299 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDPcZNKSzVyPUCuNVIzOzNizszN M3;UOnNCVkeHUh?=
KARPAS-422 NEHodpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPPTWM2OD1yLkGyOFMzKM7:TR?= M1qxcnNCVkeHUh?=
LOXIMVI MnHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMUK1NVUh|ryP Ml;BV2FPT0WU
SCC-3 NW\pUIdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX0TXhKSzVyPUCuNVI5PTFizszN M3;TVnNCVkeHUh?=
LU-139 NUPQPJU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP2UnJKSzVyPUCuNVI6PzVizszN MYXTRW5ITVJ?
COLO-320-HSR NV\aZnk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nr[mlEPTB;MD6xN|A5PiEQvF2= NXvIXFYxW0GQR1XS
ONS-76 M37hcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXZTWM2OD1yLkGzNVMh|ryP MWLTRW5ITVJ?
U-266 NFrTU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PPb2lEPTB;MD6xN|I1PSEQvF2= MUDTRW5ITVJ?
HH M2PnOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYOwe5l6UUN3ME2wMlE{PTN3IN88US=> M2LlUXNCVkeHUh?=
BB49-HNC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHKTWM2OD1yLkGzOVg4KM7:TR?= MlTUV2FPT0WU
NCI-SNU-5 M4XQS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M125eGlEPTB;MD6xN|U6PiEQvF2= NIq4dYlUSU6JRWK=
C2BBe1 NIDWWJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMUO3OFYh|ryP NVPxeo9HW0GQR1XS
ML-2 M2HpOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVW3elU5UUN3ME2wMlE{QTV|IN88US=> NGHRZnFUSU6JRWK=
SCH NW\4bnhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\CWmlEPTB;MD6xN|k4PCEQvF2= MXTTRW5ITVJ?
NCI-H82 MmDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWj3W3g6UUN3ME2wMlE1OTB2IN88US=> NHrrTXRUSU6JRWK=
MDA-MB-134-VI NFznb|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMUSyOVIh|ryP NEnOcHBUSU6JRWK=
SK-N-DZ NUjifFIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYmzb3V6UUN3ME2wMlE1PzF7IN88US=> NGDOe5lUSU6JRWK=
HL-60 M4O1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:0SndkUUN3ME2wMlE1QTJizszN M2\JZnNCVkeHUh?=
LB373-MEL-D NX7Nc4FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHIeXhKSzVyPUCuNVU2OzlizszN NWfqV2JbW0GQR1XS
LB831-BLC NHrQfmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnicVcxUUN3ME2wMlE3ODd4IN88US=> MVrTRW5ITVJ?
SK-NEP-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEH6To5KSzVyPUCuNVYyODFizszN MXPTRW5ITVJ?
IMR-5 NXvWe4tUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXkfolzUUN3ME2wMlE3PDh|IN88US=> M3H1XnNCVkeHUh?=
Calu-6 Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M36x[mlEPTB;MD6xOlU{PyEQvF2= MUfTRW5ITVJ?
NCI-H1882 M125SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HvOmlEPTB;MD6xOlczQCEQvF2= MWjTRW5ITVJ?
NCI-H446 NGnqPVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMU[4PVEh|ryP M3;odHNCVkeHUh?=
GI-ME-N NFr2UJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;4SW9FUUN3ME2wMlE5ODJizszN MVTTRW5ITVJ?
MPP-89 M3fXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXCTWM2OD1yLkG4NVIyKM7:TR?= M2fFeXNCVkeHUh?=
CGTH-W-1 NFfiOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlO3TWM2OD1yLkG4OFM3KM7:TR?= NX6yUZg6W0GQR1XS
MEG-01 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMUi2Nlgh|ryP MW\TRW5ITVJ?
NCI-H748 NGHFV2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLObmtKSzVyPUCuNVg6OTFizszN MW\TRW5ITVJ?
COLO-829 NYK5eld[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfEU|hVUUN3ME2wMlIxPjd|IN88US=> NEfEZmRUSU6JRWK=
GOTO MmjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMkC3N{DPxE1? NH\NSlhUSU6JRWK=
EW-3 MoTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMkG3NVgh|ryP NYnCUplsW0GQR1XS
KY821 Ml7sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFniSndKSzVyPUCuNlIxPDVizszN M1LTNHNCVkeHUh?=
CTB-1 NX3JXI9jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\yeWlEPTB;MD6yNlIzQCEQvF2= M{XDe3NCVkeHUh?=
TALL-1 M{[xXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPCW4VKSzVyPUCuNlI6OjFizszN M{m1U3NCVkeHUh?=
NCI-H209 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LTOGlEPTB;MD6yNlk3OiEQvF2= MoLzV2FPT0WU
IST-MES1 MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXYVphsUUN3ME2wMlI{PTFizszN MVjTRW5ITVJ?
DMS-114 NHnYNYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\hTGlEPTB;MD6yN|k6OyEQvF2= MmTpV2FPT0WU
SNU-C2B NE\4ZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMkSzNVYh|ryP NUPwXolKW0GQR1XS
DG-75 MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMk[xPVUh|ryP M4ToPHNCVkeHUh?=
D-336MG M3rnXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULzN5ViUUN3ME2wMlI3PTV5IN88US=> M{DwOHNCVkeHUh?=
KMOE-2 MnWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMke1N|gh|ryP MojxV2FPT0WU
NB1 NWPtO2hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTlTWM2OD1yLkK3PVI3KM7:TR?= Mly5V2FPT0WU
RH-1 NVTFdIhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMke5PFkh|ryP Ml;zV2FPT0WU
TE-1 M3HoNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzNNWxUUUN3ME2wMlI5PDd7IN88US=> MYTTRW5ITVJ?
RPMI-6666 NFzhT5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[yTWM2OD1yLkK4PFQh|ryP NWTySGtwW0GQR1XS
TE-9 NYHaSGl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIT0RW5KSzVyPUCuNlg6QDVizszN NYLnXnFiW0GQR1XS
BT-474 Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFftS3lKSzVyPUCuNlk{OzRizszN NE\NdGJUSU6JRWK=
COLO-668 MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLaTWM2OD1yLkK5OFI6KM7:TR?= M2q3RnNCVkeHUh?=
NCI-H1581 MmfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj0dY5KSzVyPUCuNlk3QDlizszN NHrnOY9USU6JRWK=
MN-60 MnLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMkm5NFUh|ryP M4\sRnNCVkeHUh?=
L-540 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XKeGlEPTB;MD6zNFA5OSEQvF2= NWHEOJgxW0GQR1XS
MOLT-13 MlPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHWbYROUUN3ME2wMlMxOTh|IN88US=> Mm\3V2FPT0WU
NCI-SNU-16 NHHzXGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwM{CyNFUh|ryP NVHPXXo6W0GQR1XS
NCI-H64 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwM{CzN|Eh|ryP NH7SUJRUSU6JRWK=
CP66-MEL M3HNfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHXTWM2OD1yLkOxOFE2KM7:TR?= MVTTRW5ITVJ?
NB69 NYDsNYRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[ze2RpUUN3ME2wMlMzOTh6IN88US=> MVHTRW5ITVJ?
NCI-H2196 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrFSJFlUUN3ME2wMlM{ODN4IN88US=> MVnTRW5ITVJ?
MHH-CALL-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXradHh3UUN3ME2wMlM{PDZ6IN88US=> MXTTRW5ITVJ?
HCC2157 NXL6SJZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M363fWlEPTB;MD6zN|k2PCEQvF2= M4jvdXNCVkeHUh?=
LS-1034 MnTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\sZWlEPTB;MD6zOlM5QCEQvF2= MmDlV2FPT0WU
BOKU NF\IO|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\vblJKSzVyPUCuN|cyQTlizszN MWDTRW5ITVJ?
GDM-1 NEH2R4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwM{eyN|Qh|ryP NYP5UlBEW0GQR1XS
TGW NGm2d4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPyO4FiUUN3ME2wMlM4PDV|IN88US=> MWjTRW5ITVJ?
SNU-C1 M3vzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPsTWM2OD1yLkO4NlE2KM7:TR?= M1\zOHNCVkeHUh?=
LS-513 NX3VRXBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXldopKSzVyPUCuN|kxPzFizszN NEOyUG5USU6JRWK=
NOMO-1 NGjrcpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXiZm9IUUN3ME2wMlM6QTdzIN88US=> MnvQV2FPT0WU
MS-1 MnrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPYNGVmUUN3ME2wMlQxOTd5IN88US=> MYLTRW5ITVJ?
EKVX NWjXcpdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwNES0OlEh|ryP NXi0UIJEW0GQR1XS
SK-MEL-2 NILYTG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwNE[0JO69VQ>? M1jKVnNCVkeHUh?=
HCC1187 M2XEbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwNE[3Olgh|ryP M4n1TXNCVkeHUh?=
HCC2218 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFm5XIlKSzVyPUCuOFczOjdizszN MXXTRW5ITVJ?
NCI-H187 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17kWmlEPTB;MD60O|g1KM7:TR?= NVvrWHV[W0GQR1XS
DB MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXa[pRwUUN3ME2wMlUxODV3IN88US=> Mon6V2FPT0WU
NCI-H69 NV3wUHQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwNUCyOFch|ryP NVHkRlFKW0GQR1XS
NCI-H1694 MnTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrKVG5KSzVyPUCuOVA3QTdizszN M4TZSHNCVkeHUh?=
CA46 M{e1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXWO45KSzVyPUCuOVA6OTdizszN MVLTRW5ITVJ?
EHEB NWTNSow2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwNUGxPVMh|ryP MlKxV2FPT0WU
NCCIT MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwNUSzNlEh|ryP MlLoV2FPT0WU
NCI-H720 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwNUS5OlIh|ryP NXTySodXW0GQR1XS
LU-134-A NEDE[mNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwNUWyPVYh|ryP NUfKfW1bW0GQR1XS
MC-CAR NHTaPVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13wemlEPTB;MD61OVQ{OSEQvF2= MV7TRW5ITVJ?
NEC8 NEPpeGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwNU[xO|Ih|ryP NXj6OmdFW0GQR1XS
NCI-H524 NHXWOm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvQTWM2OD1yLkW4O|Q5KM7:TR?= M4jPfXNCVkeHUh?=
NCI-H1963 M13CXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{X0N2lEPTB;MD62NlU5KM7:TR?= MVXTRW5ITVJ?
SU-DHL-1 NFrmXmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP1TWM2OD1yLk[0OVI3KM7:TR?= M4G1SXNCVkeHUh?=
NCI-H1522 MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwNkS4PFMh|ryP NHGxfYJUSU6JRWK=
NCI-H1155 MoTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NISzVmlKSzVyPUCuOlU{PSEQvF2= M3;pTXNCVkeHUh?=
D-263MG NFiyNYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PUeWlEPTB;MD62OlExOSEQvF2= NXviTox1W0GQR1XS
TE-6 MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvOfJhKSzVyPUCuOlgyODRizszN NYHyTW5mW0GQR1XS
NCI-H1417 M{Dw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwNkm3NVEh|ryP MWjTRW5ITVJ?
NCI-H510A M2S4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PFfWlEPTB;MD63O|I{PiEQvF2= NYHBfG01W0GQR1XS
KARPAS-45 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHBcHhmUUN3ME2wMlc5OjN3IN88US=> MoPxV2FPT0WU
IST-SL1 M3i2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwOEW4NlUh|ryP MoHCV2FPT0WU
COLO-824 M2nrfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHOXJZKSzVyPUCuPFc5OzVizszN NEKwN2JUSU6JRWK=
NCI-H526 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnMTWM2OD1yLkmwPVU5KM7:TR?= NFfod29USU6JRWK=
NCI-H719 MoXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXvNW5KSzVyPUCuPVY3PTdizszN NVi4PVJmW0GQR1XS
SF539 NVTQZWZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{CzUGlEPTB;MD65PFM6PiEQvF2= Ml[yV2FPT0WU
NKM-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfZTWM2OD1yLkm4OlY{KM7:TR?= NWfv[o5mW0GQR1XS
A253 NVLQ[3pTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHESppiUUN3ME2wMlk5QDh3IN88US=> MXfTRW5ITVJ?
TE-441-T NFr6NIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfpTJBKSzVyPUGuNFQ{PSEQvF2= MlL5V2FPT0WU
COR-L88 NFjCSWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvjTWM2OD1zLkGxN|U1KM7:TR?= M2qxOnNCVkeHUh?=
CPC-N M1Pscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHESZlKSzVyPUGuNVU5QDhizszN MUTTRW5ITVJ?
NCI-H2107 NULTd5ZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPSTWM2OD1zLkG3NlYyKM7:TR?= MYDTRW5ITVJ?
ECC4 NWDLXXlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DZOGlEPTB;MT6xPFY6OyEQvF2= MV3TRW5ITVJ?
NCI-H2141 NHjRbVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFwMUmyPVkh|ryP MYTTRW5ITVJ?
NCI-H1770 M2j2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2SyfmlEPTB;MT6zNlkzQCEQvF2= NHHEdJJUSU6JRWK=
NCI-SNU-1 NGPufYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP3T4pKSzVyPUGuN|MxPCEQvF2= NUnkNXFsW0GQR1XS
LU-165 NV30XVBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3v2[GlEPTB;MT60OVQ3PyEQvF2= MXzTRW5ITVJ?
Raji NEP0XY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTFwNEeyOVkh|ryP MUHTRW5ITVJ?
EW-24 NF\MN5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfFTWM2OD1zLkW0OlE6KM7:TR?= MVLTRW5ITVJ?
KP-N-RT-BM-1 M4nQWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1WyXGlEPTB;MT61OlU2OSEQvF2= M{HPdnNCVkeHUh?=
SK-MEL-1 MmPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWOxWoRNUUN3ME2xMlY1QDd5IN88US=> NXq1cHNnW0GQR1XS
SCLC-21H MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTyTWM2OD1zLk[2OlUyKM7:TR?= M1\ufXNCVkeHUh?=
SIMA M2jhRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlz1TWM2OD1zLk[4NlM{KM7:TR?= MVrTRW5ITVJ?
NCI-H1304 NEjQTpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTFwN{C3OlUh|ryP Moi5V2FPT0WU
REH NUnlUWUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLBUG01UUN3ME2xMlcyODd6IN88US=> MV7TRW5ITVJ?
KP-N-YS M{DkUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn0Vmg{UUN3ME2xMlk{PTVzIN88US=> M2\uTXNCVkeHUh?=
DMS-153 NWrGO|ljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXPOmpwUUN3ME2xMlk4PTlizszN M13KdXNCVkeHUh?=
NB10 NGXyV2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7EPVBXUUN3ME2yMlIxQDd6IN88US=> MlG2V2FPT0WU
NCI-H345 NXjCfo9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nObWlEPTB;Mj62NVkxPSEQvF2= MXTTRW5ITVJ?
SK-N-FI NEe0eGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXqVm1KSzVyPUKuO|U{QDFizszN MX3TRW5ITVJ?
NCI-H1092 NVf0bYtvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDVcm9KSzVyPUKuPVU{QTRizszN NWOxbJNZW0GQR1XS
KM-H2 MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTXepRzUUN3ME2zMlY2Ozl4IN88US=> MYPTRW5ITVJ?
KG-1 M1vuV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPLXI5KSzVyPUOuO|E3QDhizszN NXzIW3d6W0GQR1XS
D-283MED M4nv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2THN2lEPTB;Mz63OVg4KM7:TR?= M2TRWHNCVkeHUh?=
LU-65 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXUTWM2OD12LkGxOFg2KM7:TR?= NFS0Om5USU6JRWK=
MSTO-211H NVX3dHU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjMPWtKSzVyPUSuNVg5QThizszN NH;kd|NUSU6JRWK=
NCI-H2081 NWW0NndlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1S5S2lEPTB;ND6yPVE4PCEQvF2= MlXFV2FPT0WU
D-247MG NVHSU3NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnIRmFpUUN3ME20MlQ{OTlzIN88US=> MnrZV2FPT0WU
P31-FUJ MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr5O5dHUUN3ME20MlQ2ODF7IN88US=> MVvTRW5ITVJ?
DMS-79 M2L6Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jKTmlEPTB;ND65N|E5OyEQvF2= MXzTRW5ITVJ?
KASUMI-1 MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\3TWM2OD12Lkm3OVA6KM7:TR?= MULTRW5ITVJ?
JVM-3 NUS1S5ByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYW0cWRkUUN3ME21MlI2ODF2IN88US=> MnnjV2FPT0WU
LAN-6 NELKRlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{D4UWlEPTB;NT61NVc{PiEQvF2= MmW1V2FPT0WU
DJM-1 MoPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;OSGVKSzVyPUWuOVYxOjlizszN MWPTRW5ITVJ?
JVM-2 NVTIPVBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPLSpFSUUN3ME21MlY4ODl{IN88US=> M4PTNHNCVkeHUh?=
U-87-MG MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTVwOEm5OlQh|ryP MWrTRW5ITVJ?
SHP-77 M{XHWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfiTmFTUUN3ME21Mlk1QTJ6IN88US=> MYrTRW5ITVJ?
RPMI-8866 NHzke4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LIXGlEPTB;Nj6yO|AyOyEQvF2= MmL0V2FPT0WU
ES7 NHvaXnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTFWoVKSzVyPU[uN|k6OjRizszN NGTwSIZUSU6JRWK=
WSU-NHL NYPEWJcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTZwNUG2NFkh|ryP NVruR|JyW0GQR1XS
CAS-1 M4\mWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUewVFRbUUN3ME23MlA6PzR7IN88US=> M3\hdHNCVkeHUh?=
MHH-NB-11 NYm5T49RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRThwMkOxOVIh|ryP MXHTRW5ITVJ?
ES5 Mm[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;YNIJKSzVyPUmuOVIzQDZizszN NHXqXpJUSU6JRWK=
HDLM-2 M3joUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3xTWM2OD17Lkm1PVAzKM7:TR?= M{XzdXNCVkeHUh?=
NCI-H2171 M3jueWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTFyLkW5Nlch|ryP M3zwUHNCVkeHUh?=
LNCaP-Clone-FGC Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnnTWM2OD1zMT6zO|E5KM7:TR?= M1\NPXNCVkeHUh?=
NCI-H1395 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTF{LkK2PVkh|ryP M33wZ3NCVkeHUh?=
NCI-H1436 NHXlU5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH3dFd1UUN3ME2xN{4{OTl3IN88US=> MnK4V2FPT0WU
RCC10RGB M17pcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTF|LkOyNlEh|ryP M3\xenNCVkeHUh?=
SW684 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjWUIdKSzVyPUGzMlk4QTdizszN NITBO3BUSU6JRWK=
NCI-H1650 NGXiWIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTkTWM2OD1zNT6wOFQ4KM7:TR?= M{HKcXNCVkeHUh?=
EW-13 NVvGb5RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHBVlZHUUN3ME2xOU4zODJzIN88US=> M1ra[XNCVkeHUh?=
EC-GI-10 MnTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DXWGlEPTB;MUWuPFY1PCEQvF2= M2\GUXNCVkeHUh?=
CHP-126 M3Ww[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF5LkG5NVgh|ryP MnL5V2FPT0WU
NCI-H226 NGnrXnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\yXWRHUUN3ME2xPE4xPDB|IN88US=> Mon6V2FPT0WU
NCI-H1838 MmfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\sTWM2OD1{MD6xPFQ5KM7:TR?= MXXTRW5ITVJ?
EW-11 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkCxTWM2OD1{ND6yO|E5KM7:TR?= MoHVV2FPT0WU
EB2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTNzLkWzNVgh|ryP NUnOV5hZW0GQR1XS
D-502MG NHe0VpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrre2dKSzVyPUSzMlkzOjlizszN MkfxV2FPT0WU
U-698-M NF65VnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\TeGxKSzVyPUS4Mlg3PzFizszN MYTTRW5ITVJ?
ES3 M2LRRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\TbIF7UUN3ME20PU4{QDl|IN88US=> NGHhendUSU6JRWK=

... Click to View More Cell Line Experimental Data

体内研究 Torin1在20 mg/kg剂量下,在U87MG异种移植模型中是有效的,并且在肿瘤和外周组织中对mTOR下游效应蛋白表现出良好的药效学抑制作用。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

mTORC1和 mTORC2体外激酶试验:

为产生可溶性mTORC1,HEK-293T细胞系,稳定表达N端FLAG标记的Raptor,使用水泡性口炎病毒G-假型病毒MSCV逆转录酶病毒产生。对于mTORC2,产生相似的HeLa细胞,能够稳定表达N端FLAG-标记的Protor-1。两个复合物通过在50 mm HEPES,pH 7.4,10 mm 焦磷酸钠,10 mm β-甘油磷酸钠,100 mm NaCl,2 mm EDTA,0.3% CHAPS中裂解细胞纯化。细胞在4 °C下裂解30分钟,不溶解部分通过以13,000 rpm微量离心10分钟移除。上清液与FLAG-M2单克隆抗体-琼脂糖培育1小时,然后用裂解缓冲液洗涤3次,用包含终浓度0.5 M NaCl的裂解缓冲液洗涤1次。纯化的mTORC1用100 μg/mL 3×FLAG多肽在50 mm HEPES,pH 7.4,100 mm NaCl中洗脱。将洗出液等分收集,储存在-80 °C。纯化底物S6K1 和 Akt1。激酶试验在30 °C,由激酶缓冲液(25 mm HEPES,pH 7.4,50 mm KCl,10 mm MgCl2,500 μm ATP)和150 ng 灭活的S6K1或Akt1底物组成的20 μL终体积混合物中进行。反应通过加入80 μL样品缓冲液停止,并沸煮5分钟。随后,样品通过SDS-PAGE和免疫印迹法分析。
细胞实验:[1]
+ 展开
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4天
  • Method: 细胞活性通过CellTiter-Glo发光法细胞活性测定评估。在第0天,细胞以500细胞每孔接种到96孔板,并生长过夜。第1天,细胞用适当的化合物处理,随后在第3-5天分析。对于分析,板在室温下培育60分钟,将50 μL CellTiter-Glo试剂加入每孔中,板在定轨摇床上混合12分钟。发光在标准平板光度计上定量。
    (Only for Reference)
动物实验:[2]
+ 展开
  • Animal Models: U87MG 异种移植物模型
  • Formulation: Torin1粉末首先以25 mg/mL在100% N-甲基-2-吡咯烷酮中溶解,随后以1:4 与无菌 50% PEG400稀释到5 mg/mL的终浓度
  • Dosages: 20 mg/kg
  • Administration: 腹腔注射给药,每天一次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次加入纯溶剂:
30% PEG 400+0.5% Tween80+5% Propylene glycol
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 607.62
化学式

C35H28F3N5O2

CAS号 1222998-36-8
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    How to re-constitute the inhibitor for i.p. administration?

  • 回答:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

相关mTOR产品

Tags: 购买Torin 1 | Torin 1供应商 | 采购Torin 1 | Torin 1价格 | Torin 1生产 | 订购Torin 1 | Torin 1代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID