Torin 1

目录号:S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。

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RMB 1419.84 现货
RMB 3019.04 现货
RMB 5492.28 现货
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客户使用该产品的4个实验数据:

  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

产品安全说明书

mTOR抑制剂选择性比较

生物活性

产品描述 Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。
靶点
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
体外研究

Torin1在2和10 nM浓度下分别抑制mTORC1 和mTORC2底物的磷酸化。此外,Torin1对mTOR比对PI3K (EC50 = 1800 nM)的选择性高1000倍,比对450种其它蛋白激酶的结合选择性高100倍。[1] [2] Torin1通过耐rapamycin机制引起细胞周期阻滞,并且其不依赖于mTORC2。Torin1比rapamycin更完全地干扰mTORC1依赖表现型。Cap依赖性翻译需要mTORC1耐Rapamycin的功能。[1]在近期的一项研究中,据报道Torin1通过活化人内分泌细胞系BON 中MEK/ERK/c-Jun通路,能够增加神经降压素分泌和基因表达。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 M3;vdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrRTWM2OD1yLkCwNFMxPiEQvF2= MYXTRW5ITVJ?
OCUB-M MmnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnSWJF5UUN3ME2wMlAxOTl2IN88US=> MY\TRW5ITVJ?
DOHH-2 NXTWfVRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HhSGlEPTB;MD6wNFIzPSEQvF2= NHPuPY5USU6JRWK=
NOS-1 M4mzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMECyOFIh|ryP NIjOT2RUSU6JRWK=
L-363 M1jqemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrX[nB{UUN3ME2wMlAxOjh2IN88US=> MXTTRW5ITVJ?
RL95-2 NXTS[3F3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\6fFBYUUN3ME2wMlAxOzJizszN Mn7OV2FPT0WU
BL-70 NFXQfJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInuNFBKSzVyPUCuNFA{OzdizszN NFvU[5ZUSU6JRWK=
TGBC1TKB NV[xZlJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PzbmlEPTB;MD6wNFM4QSEQvF2= MUPTRW5ITVJ?
697 M3rTPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILu[VZKSzVyPUCuNFA3OzRizszN NEDEUohUSU6JRWK=
RPMI-8226 NUPkRoJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjTUWZFUUN3ME2wMlAxPjVzIN88US=> NUPHPWoxW0GQR1XS
BL-41 NFm2eppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnGTWM2OD1yLkCwOlk3KM7:TR?= MXrTRW5ITVJ?
MRK-nu-1 NWPXO5g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3q1XWlEPTB;MD6wNFcxPyEQvF2= MVTTRW5ITVJ?
EW-1 MlXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13CUGlEPTB;MD6wNFc1QSEQvF2= NY\ENVBjW0GQR1XS
EVSA-T M2LyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:xTWM2OD1yLkCwPFkzKM7:TR?= MV3TRW5ITVJ?
HUTU-80 NFLhdWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33CbWlEPTB;MD6wNFkzQSEQvF2= NYW1clh1W0GQR1XS
VA-ES-BJ MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PrPWlEPTB;MD6wNFk5PCEQvF2= MljSV2FPT0WU
GCIY M1THR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NImyTGhKSzVyPUCuNFExODdizszN NHny[3RUSU6JRWK=
ES6 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEGwPFMh|ryP M1jBOHNCVkeHUh?=
NALM-6 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;u[HdKSzVyPUCuNFEyODJizszN M33mfXNCVkeHUh?=
LB996-RCC NEfUb2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMEGxN|ch|ryP M2m1T3NCVkeHUh?=
EW-16 M37ST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzTclBKSzVyPUCuNFEyQTJizszN Mn\uV2FPT0WU
KALS-1 MlT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XOZmlEPTB;MD6wNVE6QCEQvF2= M2XUUHNCVkeHUh?=
OPM-2 Mn3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rvcWlEPTB;MD6wNVI6KM7:TR?= NWHXfXlSW0GQR1XS
KU812 MoDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDyTWM2OD1yLkCxNlk3KM7:TR?= M3Ti[3NCVkeHUh?=
A4-Fuk M1;PNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;mdmlEPTB;MD6wNVMyQSEQvF2= NH\EOoxUSU6JRWK=
KGN NHPqdJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHXTWM2OD1yLkCxN|U6KM7:TR?= NFnzVYxUSU6JRWK=
KS-1 NXTPeHE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm3bmU6UUN3ME2wMlAyOzl{IN88US=> MkDpV2FPT0WU
no-11 NHPIWoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DudWlEPTB;MD6wNVM6PSEQvF2= NU\zSHEzW0GQR1XS
PSN1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L4d2lEPTB;MD6wNVQxQSEQvF2= MVvTRW5ITVJ?
SK-LMS-1 NFnNNpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HqcmlEPTB;MD6wNVQyOyEQvF2= NVn6UopkW0GQR1XS
LS-411N MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HaU2lEPTB;MD6wNVQ{QSEQvF2= NVW1XVlZW0GQR1XS
HT-144 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWS5S2NJUUN3ME2wMlAyPDVzIN88US=> MVHTRW5ITVJ?
ACN NULRSoI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPJUoRKUUN3ME2wMlAyPSEQvF2= MnTLV2FPT0WU
RKO NGrXR5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjSVmNjUUN3ME2wMlAyPTN|IN88US=> MnTSV2FPT0WU
CMK MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzyR4FKSzVyPUCuNFE2PDNizszN MkDRV2FPT0WU
GB-1 M2H5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfyZodKSzVyPUCuNFE2PTNizszN NGGxXYpUSU6JRWK=
KE-37 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEG1O|Mh|ryP NGDz[4lUSU6JRWK=
no-10 M3XTcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rBS2lEPTB;MD6wNVU5PCEQvF2= MlfOV2FPT0WU
MOLT-16 NYLESVFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfETYFDUUN3ME2wMlAyPjJ{IN88US=> NWnLUGhPW0GQR1XS
HEL NHPjRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HDOGlEPTB;MD6wNVY1KM7:TR?= NIrhRXpUSU6JRWK=
NCI-H1355 NV;RXFBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrLPIJKSzVyPUCuNFE3PDZizszN NUDqSIZVW0GQR1XS
IST-MEL1 NGn4coFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMEG3O|Qh|ryP Mlm3V2FPT0WU
MHH-PREB-1 NFLCfXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvNcoU1UUN3ME2wMlAyQDF6IN88US=> M3ixNHNCVkeHUh?=
ES8 NIr5eJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjYWHNQUUN3ME2wMlAyQDR2IN88US=> MlvKV2FPT0WU
LC-2-ad MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\6NmlEPTB;MD6wNlE{PyEQvF2= NYfhPIlLW0GQR1XS
LAMA-84 MoHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jKT2lEPTB;MD6wNlE3PyEQvF2= NGHSU49USU6JRWK=
BV-173 NYC1flNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETMWpRKSzVyPUCuNFIzODNizszN NYfiVmRnW0GQR1XS
SW872 NFj4co1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\0eWlEPTB;MD6wNlI1PyEQvF2= NF3XWWVUSU6JRWK=
SK-UT-1 M2DaTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknrTWM2OD1yLkCyNlYyKM7:TR?= MX7TRW5ITVJ?
OS-RC-2 NV71RWdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTlTWM2OD1yLkCyN|I{KM7:TR?= MYfTRW5ITVJ?
NCI-H747 M4r0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnmTWM2OD1yLkCyN|Mh|ryP MYLTRW5ITVJ?
MZ2-MEL M3LwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PGXmlEPTB;MD6wNlM{PyEQvF2= NVnY[3JUW0GQR1XS
TE-11 M2j2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMEKzO|Ih|ryP MVnTRW5ITVJ?
KURAMOCHI MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUezWIVJUUN3ME2wMlAzPDF2IN88US=> NES4OGJUSU6JRWK=
HD-MY-Z M{T5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEe0c5NKSzVyPUCuNFI1OjZizszN MlP4V2FPT0WU
GI-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nBWmlEPTB;MD6wNlQ3QSEQvF2= NVu4T3BJW0GQR1XS
LB1047-RCC MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnVTGJOUUN3ME2wMlAzPDh6IN88US=> NELIT5ZUSU6JRWK=
TE-12 MlH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mne5TWM2OD1yLkCyOVUh|ryP MmTMV2FPT0WU
MZ7-mel MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\sTWM2OD1yLkCyOlA6KM7:TR?= MlHIV2FPT0WU
MMAC-SF MnnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjqTWM2OD1yLkCyOlM{KM7:TR?= M1jaZnNCVkeHUh?=
A101D M2Lqemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljJTWM2OD1yLkCyOlUh|ryP NYT1Om1RW0GQR1XS
GR-ST MmHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj1TWM2OD1yLkCyOlU2KM7:TR?= NXX0dnFJW0GQR1XS
MC116 NXnPUIQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13mRWlEPTB;MD6wNlY5KM7:TR?= NEjGSYxUSU6JRWK=
Ramos-2G6-4C10 M{L0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMEK3OUDPxE1? MlnVV2FPT0WU
ATN-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInSV|BKSzVyPUCuNFI4QDlizszN MV\TRW5ITVJ?
MFH-ino NH3IbXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEK4NVIh|ryP Mly0V2FPT0WU
DEL NV7yT5IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn61TWM2OD1yLkCyPFE2KM7:TR?= M2TVRXNCVkeHUh?=
OCI-AML2 Ml\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;xTWM2OD1yLkCyPFcyKM7:TR?= M{\QcHNCVkeHUh?=
LXF-289 MnvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHoVotiUUN3ME2wMlAzQDd{IN88US=> MW\TRW5ITVJ?
IA-LM MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm2TWM2OD1yLkCyPVE4KM7:TR?= MUHTRW5ITVJ?
EoL-1-cell MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELXSXZKSzVyPUCuNFI6QTZizszN NGrZXVNUSU6JRWK=
OVCAR-4 NY\Zc3JET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEOwPVQh|ryP MX;TRW5ITVJ?
ES1 NWfDSYE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEOwPVch|ryP MYnTRW5ITVJ?
CESS M1zkS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMEOwPVkh|ryP NVj3fmE6W0GQR1XS
GAK M1\lfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXO[2VKSzVyPUCuNFMyQDZizszN NWq5OIh6W0GQR1XS
NTERA-S-cl-D1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzXb4dzUUN3ME2wMlA{OjJ4IN88US=> M2DuZ3NCVkeHUh?=
TE-10 NH\heXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7MTWM2OD1yLkCzN|EyKM7:TR?= Ml\sV2FPT0WU
CCRF-CEM NIPQV4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXuzfWpHUUN3ME2wMlA{OzdzIN88US=> MWfTRW5ITVJ?
NMC-G1 NVfFOGJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPuZ29KSzVyPUCuNFM1PDhizszN M4PzZXNCVkeHUh?=
HOP-62 M1\J[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDaUplvUUN3ME2wMlA{PTV4IN88US=> NVmxWoJjW0GQR1XS
SH-4 MmjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITkZXZKSzVyPUCuNFM2QDJizszN MUfTRW5ITVJ?
NCI-H1648 MmHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMEO2NlIh|ryP MX\TRW5ITVJ?
EB-3 NXXkZXVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEO2OFMh|ryP MVXTRW5ITVJ?
BB65-RCC MkLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEO2PVEh|ryP M2LoUHNCVkeHUh?=
BE-13 M33wcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;LTWM2OD1yLkCzO|U6KM7:TR?= MYDTRW5ITVJ?
CP67-MEL NIL6XYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX2[|FKSzVyPUCuNFM4PTlizszN Mnn1V2FPT0WU
SW954 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PwRmlEPTB;MD6wN|c6KM7:TR?= MY\TRW5ITVJ?
TE-5 NV\XcIh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\NeGJFUUN3ME2wMlA{QDV2IN88US=> MmPDV2FPT0WU
HCE-4 NHqwOYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PVRmlEPTB;MD6wN|g2PSEQvF2= MYnTRW5ITVJ?
LC-1F NVLtcpN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPTTWM2OD1yLkCzPVg6KM7:TR?= MoXOV2FPT0WU
TK10 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrrTWM2OD1yLkC0NFE6KM7:TR?= Mn6xV2FPT0WU
SJSA-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMESxPFgh|ryP MXXTRW5ITVJ?
Daudi MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmD0TWM2OD1yLkC0NlI2KM7:TR?= NWr5Vm9YW0GQR1XS
SW982 M1HXNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4e2bmlEPTB;MD6wOFI1PiEQvF2= NH\ienhUSU6JRWK=
SF126 NUO2cnNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzqRYZKSzVyPUCuNFQ{PjFizszN MWXTRW5ITVJ?
TE-15 NIDPOZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13vR2lEPTB;MD6wOFQ{PSEQvF2= MYDTRW5ITVJ?
COLO-684 NYe5dnpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnL0TWM2OD1yLkC0OVYyKM7:TR?= M2PSdnNCVkeHUh?=
8-MG-BA NF7CU5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LPNWlEPTB;MD6wOFYzQSEQvF2= M37rd3NCVkeHUh?=
NB13 MmjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMES3O|Yh|ryP NVPvO5NPW0GQR1XS
HCC1599 MlfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DFO2lEPTB;MD6wOFg4QSEQvF2= NXjrZZQzW0GQR1XS
SK-PN-DW M2j6bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHrPFRnUUN3ME2wMlA1QTR7IN88US=> MXrTRW5ITVJ?
ALL-PO NUXZbHhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoG0TWM2OD1yLkC0PVU3KM7:TR?= NIS4c4pUSU6JRWK=
NB6 M3i0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonDTWM2OD1yLkC1NlcyKM7:TR?= MnjoV2FPT0WU
IST-SL2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jtVGlEPTB;MD6wOVM3OiEQvF2= MXvTRW5ITVJ?
BB30-HNC M4jofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEW3N{DPxE1? MkHiV2FPT0WU
SW962 NHfp[oNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rNTmlEPTB;MD6wOVc3OyEQvF2= MYLTRW5ITVJ?
TGBC24TKB NFzZc5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M372dGlEPTB;MD6wOVc6QSEQvF2= MWPTRW5ITVJ?
KINGS-1 M4HmTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LNXWlEPTB;MD6wOVgxOyEQvF2= Mo\3V2FPT0WU
HC-1 MnPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:4TWM2OD1yLkC1PFI4KM7:TR?= MnzVV2FPT0WU
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BOKU NHLpV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwM{exPVkh|ryP NXTFfpFpW0GQR1XS
GDM-1 NXXabVFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwM{eyN|Qh|ryP MX\TRW5ITVJ?
TGW Ml;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnmTWM2OD1yLkO3OFU{KM7:TR?= NHvudXVUSU6JRWK=
SNU-C1 NV3RcXB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmCzTWM2OD1yLkO4NlE2KM7:TR?= MUfTRW5ITVJ?
LS-513 NECzb2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTNTWM2OD1yLkO5NFcyKM7:TR?= MlW0V2FPT0WU
NOMO-1 MkDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnVbo5YUUN3ME2wMlM6QTdzIN88US=> MlTKV2FPT0WU
MS-1 NX\sRYhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDz[I5oUUN3ME2wMlQxOTd5IN88US=> Mkf4V2FPT0WU
EKVX M{Tjbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDyPWtKSzVyPUCuOFQ1PjFizszN NXHPZm85W0GQR1XS
SK-MEL-2 M2\qbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwNE[0JO69VQ>? NHzxOplUSU6JRWK=
HCC1187 NIPWO2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwNE[3Olgh|ryP NWLRSXJoW0GQR1XS
HCC2218 NVnqcogyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;wUmlEPTB;MD60O|IzPyEQvF2= MUHTRW5ITVJ?
NCI-H187 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jYT2lEPTB;MD60O|g1KM7:TR?= NITjSIxUSU6JRWK=
DB NGPXOGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NES4OY1KSzVyPUCuOVAxPTVizszN NGi3VWVUSU6JRWK=
NCI-H69 NEiwdYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jq[WlEPTB;MD61NFI1PyEQvF2= MkKwV2FPT0WU
NCI-H1694 NH3TXmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37GOGlEPTB;MD61NFY6PyEQvF2= MlTsV2FPT0WU
CA46 NYSyeJhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq1XJMyUUN3ME2wMlUxQTF5IN88US=> MkTqV2FPT0WU
EHEB MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjPTppKSzVyPUCuOVEyQTNizszN M3XBVnNCVkeHUh?=
NCCIT MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jucWlEPTB;MD61OFMzOSEQvF2= NEDsd5ZUSU6JRWK=
NCI-H720 NVT3[nY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojhTWM2OD1yLkW0PVYzKM7:TR?= M4HuTXNCVkeHUh?=
LU-134-A Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwNUWyPVYh|ryP M3zaXnNCVkeHUh?=
MC-CAR NF3VSJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;KUWlEPTB;MD61OVQ{OSEQvF2= MljaV2FPT0WU
NEC8 M1i4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjETWM2OD1yLkW2NVczKM7:TR?= Ml[1V2FPT0WU
NCI-H524 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7aZ2FKSzVyPUCuOVg4PDhizszN M2PhcXNCVkeHUh?=
NCI-H1963 NWm3Oo9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j1WGlEPTB;MD62NlU5KM7:TR?= NF[1c3ZUSU6JRWK=
SU-DHL-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXtVnJKSzVyPUCuOlQ2OjZizszN MlnYV2FPT0WU
NCI-H1522 NVzn[XJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;1dmlEPTB;MD62OFg5OyEQvF2= NYPPSoFuW0GQR1XS
NCI-H1155 NFHNW41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TpUGlEPTB;MD62OVM2KM7:TR?= MYLTRW5ITVJ?
D-263MG M1XN[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fTSGlEPTB;MD62OlExOSEQvF2= MXzTRW5ITVJ?
TE-6 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LhO2lEPTB;MD62PFExPCEQvF2= M3PS[HNCVkeHUh?=
NCI-H1417 NEm0R4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvkTWM2OD1yLk[5O|EyKM7:TR?= MkTiV2FPT0WU
NCI-H510A MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwN{eyN|Yh|ryP MVnTRW5ITVJ?
KARPAS-45 NFnsTJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4H4bWlEPTB;MD63PFI{PSEQvF2= M4DX[nNCVkeHUh?=
IST-SL1 NUPzZW5TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHKwZWhKSzVyPUCuPFU5OjVizszN MUfTRW5ITVJ?
COLO-824 M4SwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwOEe4N|Uh|ryP MX3TRW5ITVJ?
NCI-H526 NHK2[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwOUC5OVgh|ryP Mn3mV2FPT0WU
NCI-H719 NGCxT3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwOU[2OVch|ryP NHXZXmhUSU6JRWK=
SF539 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorzTWM2OD1yLkm4N|k3KM7:TR?= NInMe4FUSU6JRWK=
NKM-1 NIXGW4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTHTWM2OD1yLkm4OlY{KM7:TR?= NVjMXY1JW0GQR1XS
A253 MnKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwOUi4PFUh|ryP MlnIV2FPT0WU
TE-441-T MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFwMESzOUDPxE1? NVewRohUW0GQR1XS
COR-L88 NVHmNYhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTFwMUGzOVQh|ryP NUK0NZE5W0GQR1XS
CPC-N MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnXcXpKSzVyPUGuNVU5QDhizszN NYrKe5Y{W0GQR1XS
NCI-H2107 NGXaTYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnSxTWM2OD1zLkG3NlYyKM7:TR?= NEixOIRUSU6JRWK=
ECC4 NU\pcXJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXacINKSzVyPUGuNVg3QTNizszN NIDiN5pUSU6JRWK=
NCI-H2141 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXzZohxUUN3ME2xMlE6Ojl7IN88US=> NUHt[HB[W0GQR1XS
NCI-H1770 NUDCRnlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PnPGlEPTB;MT6zNlkzQCEQvF2= M3\JbXNCVkeHUh?=
NCI-SNU-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTFwM{OwOEDPxE1? NITxfYtUSU6JRWK=
LU-165 MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfGOFFKSzVyPUGuOFU1PjdizszN NFrCO4VUSU6JRWK=
Raji MnfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{O1R2lEPTB;MT60O|I2QSEQvF2= NHTYfphUSU6JRWK=
EW-24 Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4roPWlEPTB;MT61OFYyQSEQvF2= MX;TRW5ITVJ?
KP-N-RT-BM-1 M4rFNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TLeGlEPTB;MT61OlU2OSEQvF2= NXO3fFR[W0GQR1XS
SK-MEL-1 NV7od3JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTFwNkS4O|ch|ryP NX;qd2ZlW0GQR1XS
SCLC-21H NV3pUmFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXlenpKSzVyPUGuOlY3PTFizszN M1K0VnNCVkeHUh?=
SIMA NHTBRWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYe5eplMUUN3ME2xMlY5OjN|IN88US=> NGTHbmtUSU6JRWK=
NCI-H1304 Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLY[VlKSzVyPUGuO|A4PjVizszN MnL3V2FPT0WU
REH NYmzb4dpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTDTWM2OD1zLkexNFc5KM7:TR?= MnXGV2FPT0WU
KP-N-YS MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTFwOUO1OVEh|ryP NYP3OJZyW0GQR1XS
DMS-153 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWOzZ2o4UUN3ME2xMlk4PTlizszN M2L2[XNCVkeHUh?=
NB10 M17KRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYC1UpFGUUN3ME2yMlIxQDd6IN88US=> Mn;xV2FPT0WU
NCI-H345 NH:zO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnyXnV6UUN3ME2yMlYyQTB3IN88US=> M{L2RnNCVkeHUh?=
SK-N-FI NF;ERm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPCTWM2OD1{Lke1N|gyKM7:TR?= NIfnPXNUSU6JRWK=
NCI-H1092 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJwOUWzPVQh|ryP MVXTRW5ITVJ?
KM-H2 NEG0dFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTNwNkWzPVYh|ryP MoTXV2FPT0WU
KG-1 MnjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTNwN{G2PFgh|ryP NGf0O4FUSU6JRWK=
D-283MED NHrObmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTNwN{W4O{DPxE1? MXTTRW5ITVJ?
LU-65 NHXVRpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTRwMUG0PFUh|ryP MWrTRW5ITVJ?
MSTO-211H MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTRwMUi4PVgh|ryP M2Sz[nNCVkeHUh?=
NCI-H2081 MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnq1TWM2OD12LkK5NVc1KM7:TR?= NHLCXXZUSU6JRWK=
D-247MG MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjNRmNKSzVyPUSuOFMyQTFizszN MVHTRW5ITVJ?
P31-FUJ M1rUSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nLb2lEPTB;ND60OVAyQSEQvF2= M3fzRnNCVkeHUh?=
DMS-79 Mn:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzNTWM2OD12LkmzNVg{KM7:TR?= NFTRfHNUSU6JRWK=
KASUMI-1 NETobWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkK0TWM2OD12Lkm3OVA6KM7:TR?= MWHTRW5ITVJ?
JVM-3 Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r0VWlEPTB;NT6yOVAyPCEQvF2= NHLnPJlUSU6JRWK=
LAN-6 NFfDUI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTVwNUG3N|Yh|ryP NGnTNHpUSU6JRWK=
DJM-1 MnLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTVwNU[wNlkh|ryP NXTWc5dSW0GQR1XS
JVM-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L2WGlEPTB;NT62O|A6OiEQvF2= MWjTRW5ITVJ?
U-87-MG NIHTfVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\QdlhUUUN3ME21Mlg6QTZ2IN88US=> NWHDPVI6W0GQR1XS
SHP-77 NYLrWFdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfafJlzUUN3ME21Mlk1QTJ6IN88US=> Mnz1V2FPT0WU
RPMI-8866 M4rVW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTZwMkewNVMh|ryP NVTRRYE6W0GQR1XS
ES7 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHmxR41KSzVyPU[uN|k6OjRizszN M4HUW3NCVkeHUh?=
WSU-NHL NIj3XHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXy0fnk5UUN3ME22MlUyPjB7IN88US=> MWHTRW5ITVJ?
CAS-1 MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;ZTGlEPTB;Nz6wPVc1QSEQvF2= MnvqV2FPT0WU
MHH-NB-11 NGrpTlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRThwMkOxOVIh|ryP NGHDPXVUSU6JRWK=
ES5 NFrhVmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvTTWM2OD17LkWyNlg3KM7:TR?= MkjSV2FPT0WU
HDLM-2 M3vKOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4m0dGlEPTB;OT65OVkxOiEQvF2= NWmzOHZMW0GQR1XS
NCI-H2171 NH7kdnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrWTWM2OD1zMD61PVI4KM7:TR?= MWrTRW5ITVJ?
LNCaP-Clone-FGC MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU[zXWp2UUN3ME2xNU4{PzF6IN88US=> MkLYV2FPT0WU
NCI-H1395 M3\CU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETG[45KSzVyPUGyMlI3QTlizszN NV;GcoEzW0GQR1XS
NCI-H1436 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPa[WVQUUN3ME2xN{4{OTl3IN88US=> NH7CWmNUSU6JRWK=
RCC10RGB NFq3[FZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;vR3R5UUN3ME2xN{4{OjJzIN88US=> MkXFV2FPT0WU
SW684 NGKxT3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXtTWM2OD1zMz65O|k4KM7:TR?= MXTTRW5ITVJ?
NCI-H1650 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvJVXh7UUN3ME2xOU4xPDR5IN88US=> M37PWHNCVkeHUh?=
EW-13 M{SwN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLhN|lKSzVyPUG1MlIxOjFizszN NGGzU2ZUSU6JRWK=
EC-GI-10 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzETWM2OD1zNT64OlQ1KM7:TR?= NV7VRVNxW0GQR1XS
CHP-126 NV24N|N1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTF5LkG5NVgh|ryP NVf2R4JCW0GQR1XS
NCI-H226 NUHUXlhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTF6LkC0NFMh|ryP NXzXS41ZW0GQR1XS
NCI-H1838 NIXSPHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfZelRpUUN3ME2yNE4yQDR6IN88US=> MniyV2FPT0WU
EW-11 NFHUWJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJ2LkK3NVgh|ryP M4nTVHNCVkeHUh?=
EB2 NG\hVmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrIbpBKSzVyPUOxMlU{OThizszN NUXUS5RxW0GQR1XS
D-502MG M2DBfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzpTFE5UUN3ME20N{46OjJ7IN88US=> NWPwXmRPW0GQR1XS
U-698-M NWXveYJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NICyb4lKSzVyPUS4Mlg3PzFizszN M1[4SXNCVkeHUh?=
ES3 NULOWHp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrIZnlKSzVyPUS5MlM5QTNizszN NHL3XppUSU6JRWK=

... Click to View More Cell Line Experimental Data

体内研究 Torin1在20 mg/kg剂量下,在U87MG异种移植模型中是有效的,并且在肿瘤和外周组织中对mTOR下游效应蛋白表现出良好的药效学抑制作用。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

mTORC1和 mTORC2体外激酶试验:

为产生可溶性mTORC1,HEK-293T细胞系,稳定表达N端FLAG标记的Raptor,使用水泡性口炎病毒G-假型病毒MSCV逆转录酶病毒产生。对于mTORC2,产生相似的HeLa细胞,能够稳定表达N端FLAG-标记的Protor-1。两个复合物通过在50 mm HEPES,pH 7.4,10 mm 焦磷酸钠,10 mm β-甘油磷酸钠,100 mm NaCl,2 mm EDTA,0.3% CHAPS中裂解细胞纯化。细胞在4 °C下裂解30分钟,不溶解部分通过以13,000 rpm微量离心10分钟移除。上清液与FLAG-M2单克隆抗体-琼脂糖培育1小时,然后用裂解缓冲液洗涤3次,用包含终浓度0.5 M NaCl的裂解缓冲液洗涤1次。纯化的mTORC1用100 μg/mL 3×FLAG多肽在50 mm HEPES,pH 7.4,100 mm NaCl中洗脱。将洗出液等分收集,储存在-80 °C。纯化底物S6K1 和 Akt1。激酶试验在30 °C,由激酶缓冲液(25 mm HEPES,pH 7.4,50 mm KCl,10 mm MgCl2,500 μm ATP)和150 ng 灭活的S6K1或Akt1底物组成的20 μL终体积混合物中进行。反应通过加入80 μL样品缓冲液停止,并沸煮5分钟。随后,样品通过SDS-PAGE和免疫印迹法分析。
细胞实验:[1]
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  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4天
  • Method: 细胞活性通过CellTiter-Glo发光法细胞活性测定评估。在第0天,细胞以500细胞每孔接种到96孔板,并生长过夜。第1天,细胞用适当的化合物处理,随后在第3-5天分析。对于分析,板在室温下培育60分钟,将50 μL CellTiter-Glo试剂加入每孔中,板在定轨摇床上混合12分钟。发光在标准平板光度计上定量。
    (Only for Reference)
动物实验:[2]
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  • Animal Models: U87MG 异种移植物模型
  • Formulation: Torin1粉末首先以25 mg/mL在100% N-甲基-2-吡咯烷酮中溶解,随后以1:4 与无菌 50% PEG400稀释到5 mg/mL的终浓度
  • Dosages: 20 mg/kg
  • Administration: 腹腔注射给药,每天一次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次加入纯溶剂:
30% PEG 400+0.5% Tween80+5% Propylene glycol
30mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 607.62
化学式

C35H28F3N5O2

CAS号 1222998-36-8
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    How to re-constitute the inhibitor for i.p. administration?

  • 回答:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID