Torin 1

目录号:S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。

规格 价格 库存 购买数量  
RMB 1419.84 现货
RMB 3019.04 现货
RMB 5492.28 现货
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客户使用该产品的4个实验数据:

  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

产品安全说明书

mTOR抑制剂选择性比较

生物活性

产品描述 Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。
靶点
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
体外研究

Torin1在2和10 nM浓度下分别抑制mTORC1 和mTORC2底物的磷酸化。此外,Torin1对mTOR比对PI3K (EC50 = 1800 nM)的选择性高1000倍,比对450种其它蛋白激酶的结合选择性高100倍。[1] [2] Torin1通过耐rapamycin机制引起细胞周期阻滞,并且其不依赖于mTORC2。Torin1比rapamycin更完全地干扰mTORC1依赖表现型。Cap依赖性翻译需要mTORC1耐Rapamycin的功能。[1]在近期的一项研究中,据报道Torin1通过活化人内分泌细胞系BON 中MEK/ERK/c-Jun通路,能够增加神经降压素分泌和基因表达。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 M3HKe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7YWndKSzVyPUCuNFAxOzB4IN88US=> M3zrcXNCVkeHUh?=
OCUB-M M1fRVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMECxPVQh|ryP MoTtV2FPT0WU
DOHH-2 MoPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS2TWM2OD1yLkCwNlI2KM7:TR?= NHeyUJpUSU6JRWK=
NOS-1 M4XhSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3jW41KSzVyPUCuNFAzPDJizszN MoHMV2FPT0WU
L-363 MnPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC4TWM2OD1yLkCwNlg1KM7:TR?= NVH4W|V{W0GQR1XS
RL95-2 NIGyc|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPCTWM2OD1yLkCwN|Ih|ryP MUHTRW5ITVJ?
BL-70 NEf2c2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\rbWlEPTB;MD6wNFM{PyEQvF2= MYDTRW5ITVJ?
TGBC1TKB M1j5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPtPHIyUUN3ME2wMlAxOzd7IN88US=> M1WxXXNCVkeHUh?=
697 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEG0S25KSzVyPUCuNFA3OzRizszN MVXTRW5ITVJ?
RPMI-8226 M2S4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLyPI5KSzVyPUCuNFA3PTFizszN NHTJU49USU6JRWK=
BL-41 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPtTWM2OD1yLkCwOlk3KM7:TR?= MYjTRW5ITVJ?
MRK-nu-1 NWP0UXpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMEC3NFch|ryP NH;DWWZUSU6JRWK=
EW-1 MnjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMEC3OFkh|ryP MkiwV2FPT0WU
EVSA-T MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vjfGlEPTB;MD6wNFg6OiEQvF2= NYWzXVR7W0GQR1XS
HUTU-80 NXLlVXVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMEC5Nlkh|ryP MYLTRW5ITVJ?
VA-ES-BJ NEfocJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEC5PFQh|ryP NUmyS5pvW0GQR1XS
GCIY MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILMUphKSzVyPUCuNFExODdizszN MmjWV2FPT0WU
ES6 NVXSbXU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEGwPFMh|ryP NX\EVVExW0GQR1XS
NALM-6 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojNTWM2OD1yLkCxNVAzKM7:TR?= NIfuXphUSU6JRWK=
LB996-RCC NGi5OYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfhNlZKSzVyPUCuNFEyOzdizszN NFX1WlNUSU6JRWK=
EW-16 NV\zSnlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fOcWlEPTB;MD6wNVE6OiEQvF2= NX7ndWJ1W0GQR1XS
KALS-1 M3eyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M323XmlEPTB;MD6wNVE6QCEQvF2= M1fzUXNCVkeHUh?=
OPM-2 M{DuWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r1dGlEPTB;MD6wNVI6KM7:TR?= MlO5V2FPT0WU
KU812 NEfrclRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEGyPVYh|ryP NH6zRXJUSU6JRWK=
A4-Fuk MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDtTWM2OD1yLkCxN|E6KM7:TR?= MVHTRW5ITVJ?
KGN NULzcpZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrqOHlKSzVyPUCuNFE{PTlizszN MYjTRW5ITVJ?
KS-1 MlPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEGzPVIh|ryP Mnz1V2FPT0WU
no-11 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEGzPVUh|ryP NILLTlNUSU6JRWK=
PSN1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEG0NFkh|ryP NG[yd|FUSU6JRWK=
SK-LMS-1 M{POcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\RU3ZIUUN3ME2wMlAyPDF|IN88US=> NEnPb3FUSU6JRWK=
LS-411N MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojLTWM2OD1yLkCxOFM6KM7:TR?= M3jVN3NCVkeHUh?=
HT-144 MlPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPFTWM2OD1yLkCxOFUyKM7:TR?= Ml;VV2FPT0WU
ACN MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEG1JO69VQ>? NELHSHBUSU6JRWK=
RKO NFT6OlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;ETWM2OD1yLkCxOVM{KM7:TR?= MWfTRW5ITVJ?
CMK M33RS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMEG1OFMh|ryP NIX5dJFUSU6JRWK=
GB-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LpbWlEPTB;MD6wNVU2OyEQvF2= M3npWnNCVkeHUh?=
KE-37 M3LkN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILFOVlKSzVyPUCuNFE2PzNizszN NH3Id2RUSU6JRWK=
no-10 M1z5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkeyTWM2OD1yLkCxOVg1KM7:TR?= MYDTRW5ITVJ?
MOLT-16 NHnBcJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz1TWM2OD1yLkCxOlIzKM7:TR?= MXTTRW5ITVJ?
HEL NHXmS2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjJXXJwUUN3ME2wMlAyPjRizszN M{HjVXNCVkeHUh?=
NCI-H1355 NIrH[4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1mxWWlEPTB;MD6wNVY1PiEQvF2= NYq2PHF1W0GQR1XS
IST-MEL1 NYq3UlB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PlUWlEPTB;MD6wNVc4PCEQvF2= NYPhfYRzW0GQR1XS
MHH-PREB-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4OySWlEPTB;MD6wNVgyQCEQvF2= NVHmbFN5W0GQR1XS
ES8 Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H1OmlEPTB;MD6wNVg1PCEQvF2= MUnTRW5ITVJ?
LC-2-ad NEf6bItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vMVmlEPTB;MD6wNlE{PyEQvF2= MoD2V2FPT0WU
LAMA-84 MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMEKxOlch|ryP NH:4V3VUSU6JRWK=
BV-173 NXnONZJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEKyNFMh|ryP MVTTRW5ITVJ?
SW872 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEKyOFch|ryP MmLZV2FPT0WU
SK-UT-1 MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjxTWM2OD1yLkCyNlYyKM7:TR?= NXr4N3h{W0GQR1XS
OS-RC-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEKzNlMh|ryP M2TtcnNCVkeHUh?=
NCI-H747 M{TTOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEKzN{DPxE1? NFT4[5RUSU6JRWK=
MZ2-MEL M1nTdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEKzN|ch|ryP MkHlV2FPT0WU
TE-11 MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLYTlFKSzVyPUCuNFI{PzJizszN NELQbmxUSU6JRWK=
KURAMOCHI M3K2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vF[WlEPTB;MD6wNlQyPCEQvF2= Ml2xV2FPT0WU
HD-MY-Z M2DQeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFuzV5BKSzVyPUCuNFI1OjZizszN M1nKSHNCVkeHUh?=
GI-1 NUTyZmNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknjTWM2OD1yLkCyOFY6KM7:TR?= MkDPV2FPT0WU
LB1047-RCC MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjVXFR6UUN3ME2wMlAzPDh6IN88US=> NUG3cVRCW0GQR1XS
TE-12 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHjTWM2OD1yLkCyOVUh|ryP M2HGSHNCVkeHUh?=
MZ7-mel NXjZS|hFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEK2NFkh|ryP M4L4OHNCVkeHUh?=
MMAC-SF MnzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkf1TWM2OD1yLkCyOlM{KM7:TR?= M3LocXNCVkeHUh?=
A101D MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMEK2OUDPxE1? MXnTRW5ITVJ?
GR-ST MknRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;IRZRKSzVyPUCuNFI3PTVizszN NGfnRXlUSU6JRWK=
MC116 M{nDO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jpOGlEPTB;MD6wNlY5KM7:TR?= NIPzNoZUSU6JRWK=
Ramos-2G6-4C10 MoDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jU[GlEPTB;MD6wNlc2KM7:TR?= M4DPSHNCVkeHUh?=
ATN-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTPfHlFUUN3ME2wMlAzPzh7IN88US=> NHHoPHFUSU6JRWK=
MFH-ino MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfCN2ZKSzVyPUCuNFI5OTJizszN MnfwV2FPT0WU
DEL MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\2cXFRUUN3ME2wMlAzQDF3IN88US=> Mn7uV2FPT0WU
OCI-AML2 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrMdZJHUUN3ME2wMlAzQDdzIN88US=> MUTTRW5ITVJ?
LXF-289 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMEK4O|Ih|ryP M4DJfXNCVkeHUh?=
IA-LM M4rifWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfiTWM2OD1yLkCyPVE4KM7:TR?= MnvtV2FPT0WU
EoL-1-cell NGnnXldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrINGRuUUN3ME2wMlAzQTl4IN88US=> M3zYcXNCVkeHUh?=
OVCAR-4 NHjOfZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMEOwPVQh|ryP NVzsXGtpW0GQR1XS
ES1 NX;1fVYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFT6WWxKSzVyPUCuNFMxQTdizszN MWTTRW5ITVJ?
CESS NE\vVldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEOwPVkh|ryP NIj3UIFUSU6JRWK=
GAK M3v3SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEOxPFYh|ryP MXnTRW5ITVJ?
NTERA-S-cl-D1 MoTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;rRXZKSzVyPUCuNFMzOjZizszN M3LLXXNCVkeHUh?=
TE-10 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjGeVNKSzVyPUCuNFM{OTFizszN M3r0fXNCVkeHUh?=
CCRF-CEM MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C3OmlEPTB;MD6wN|M4OSEQvF2= NGm4do9USU6JRWK=
NMC-G1 NFfpelVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjwNJlKSzVyPUCuNFM1PDhizszN MlvtV2FPT0WU
HOP-62 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;qSY1KSzVyPUCuNFM2PTZizszN M2PhU3NCVkeHUh?=
SH-4 Mn6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDZTWM2OD1yLkCzOVgzKM7:TR?= M3LWV3NCVkeHUh?=
NCI-H1648 NHm3UodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMEO2NlIh|ryP NH6w[mNUSU6JRWK=
EB-3 Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEO2OFMh|ryP NGnTcmhUSU6JRWK=
BB65-RCC M{fjeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rZXmlEPTB;MD6wN|Y6OSEQvF2= Mm\wV2FPT0WU
BE-13 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mln0TWM2OD1yLkCzO|U6KM7:TR?= MlTsV2FPT0WU
CP67-MEL MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjzVI1KSzVyPUCuNFM4PTlizszN NF3rS2hUSU6JRWK=
SW954 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mke4TWM2OD1yLkCzO|kh|ryP M{D3dnNCVkeHUh?=
TE-5 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\GSGlEPTB;MD6wN|g2PCEQvF2= NGDLZ5FUSU6JRWK=
HCE-4 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DuUGlEPTB;MD6wN|g2PSEQvF2= NVX6TINUW0GQR1XS
LC-1F MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Hz[mlEPTB;MD6wN|k5QSEQvF2= NXLkOndLW0GQR1XS
TK10 M{DYNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmC1TWM2OD1yLkC0NFE6KM7:TR?= MnT1V2FPT0WU
SJSA-1 NXP3cWs5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMESxPFgh|ryP M2\2W3NCVkeHUh?=
Daudi MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnme5NSUUN3ME2wMlA1OjJ3IN88US=> MVvTRW5ITVJ?
SW982 Mk\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHS2[HZKSzVyPUCuNFQzPDZizszN M3TMRXNCVkeHUh?=
SF126 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITSTHZKSzVyPUCuNFQ{PjFizszN NGLvUZpUSU6JRWK=
TE-15 M3;KWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMES0N|Uh|ryP M3XNXnNCVkeHUh?=
COLO-684 Mm\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMES1OlEh|ryP M{Pw[nNCVkeHUh?=
8-MG-BA NWXKdGx6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMES2Nlkh|ryP NHfZd2VUSU6JRWK=
NB13 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XsV2lEPTB;MD6wOFc4PiEQvF2= MonUV2FPT0WU
HCC1599 Mk\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DxW2lEPTB;MD6wOFg4QSEQvF2= MUHTRW5ITVJ?
SK-PN-DW M{nTVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7RVJJKSzVyPUCuNFQ6PDlizszN MnfrV2FPT0WU
ALL-PO MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXlTWM2OD1yLkC0PVU3KM7:TR?= M2rnOXNCVkeHUh?=
NB6 M{ey[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEWyO|Eh|ryP MW\TRW5ITVJ?
IST-SL2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7iTWM2OD1yLkC1N|YzKM7:TR?= M1vicHNCVkeHUh?=
BB30-HNC M17rWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMEW3N{DPxE1? MnjRV2FPT0WU
SW962 NFjFcplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwMEW3OlMh|ryP MYrTRW5ITVJ?
TGBC24TKB MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofoTWM2OD1yLkC1O|k6KM7:TR?= MUDTRW5ITVJ?
KINGS-1 Ml7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;0UoJ2UUN3ME2wMlA2QDB|IN88US=> NX7Xd|hWW0GQR1XS
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GDM-1 Mn3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37zNGlEPTB;MD6zO|I{PCEQvF2= MULTRW5ITVJ?
TGW M17LO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwM{e0OVMh|ryP MnT6V2FPT0WU
SNU-C1 NFL6Z2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHS1bFlKSzVyPUCuN|gzOTVizszN NX3qUoxpW0GQR1XS
LS-513 NXLhfYNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\RS2lEPTB;MD6zPVA4OSEQvF2= Mm\lV2FPT0WU
NOMO-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwM{m5O|Eh|ryP MXzTRW5ITVJ?
MS-1 M2e3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwNECxO|ch|ryP MUDTRW5ITVJ?
EKVX MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj5SW9KSzVyPUCuOFQ1PjFizszN NYXqd4VJW0GQR1XS
SK-MEL-2 Mn\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYL2[HB5UUN3ME2wMlQ3PCEQvF2= NIfWOplUSU6JRWK=
HCC1187 NILGWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fScmlEPTB;MD60Olc3QCEQvF2= NV;nTIdtW0GQR1XS
HCC2218 NFPhbGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELOTVFKSzVyPUCuOFczOjdizszN M13aSXNCVkeHUh?=
NCI-H187 M1TPTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwNEe4OEDPxE1? M4\aenNCVkeHUh?=
DB MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwNUCwOVUh|ryP M3;C[nNCVkeHUh?=
NCI-H69 NGDjVVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnHTWM2OD1yLkWwNlQ4KM7:TR?= NU[zS3F1W0GQR1XS
NCI-H1694 NYnqXlZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfncm9lUUN3ME2wMlUxPjl5IN88US=> MUXTRW5ITVJ?
CA46 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3XU4tKSzVyPUCuOVA6OTdizszN MYTTRW5ITVJ?
EHEB M2Ow[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPDdnNKSzVyPUCuOVEyQTNizszN NHvQelFUSU6JRWK=
NCCIT NFjoXnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TLPWlEPTB;MD61OFMzOSEQvF2= MXrTRW5ITVJ?
NCI-H720 NGTqU3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwNUS5OlIh|ryP MljsV2FPT0WU
LU-134-A MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwNUWyPVYh|ryP MlTNV2FPT0WU
MC-CAR NXj1cXB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP5TWM2OD1yLkW1OFMyKM7:TR?= NHnyXHFUSU6JRWK=
NEC8 NVzLVJFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLnTWM2OD1yLkW2NVczKM7:TR?= MnzKV2FPT0WU
NCI-H524 NILFPJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDlTWM2OD1yLkW4O|Q5KM7:TR?= NYL6O3ZRW0GQR1XS
NCI-H1963 NH;rU3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vJZWlEPTB;MD62NlU5KM7:TR?= Mm\2V2FPT0WU
SU-DHL-1 NUnBd3ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTKXFFqUUN3ME2wMlY1PTJ4IN88US=> M1;MRXNCVkeHUh?=
NCI-H1522 M4GyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDLZndxUUN3ME2wMlY1QDh|IN88US=> M3PuNnNCVkeHUh?=
NCI-H1155 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\QenA{UUN3ME2wMlY2OzVizszN NUTZV4JzW0GQR1XS
D-263MG M1Tnd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXxTWM2OD1yLk[2NVAyKM7:TR?= M2e2UnNCVkeHUh?=
TE-6 M1PVZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXMW3dKSzVyPUCuOlgyODRizszN M1PlPXNCVkeHUh?=
NCI-H1417 M3nBRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwNkm3NVEh|ryP MmfEV2FPT0WU
NCI-H510A NEWyRYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF75TopKSzVyPUCuO|czOzZizszN Mn7GV2FPT0WU
KARPAS-45 MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrKUYp2UUN3ME2wMlc5OjN3IN88US=> MnnaV2FPT0WU
IST-SL1 M3nnT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHCUGNuUUN3ME2wMlg2QDJ3IN88US=> MVLTRW5ITVJ?
COLO-824 Ml[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwOEe4N|Uh|ryP MX;TRW5ITVJ?
NCI-H526 Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwOUC5OVgh|ryP M4mwV3NCVkeHUh?=
NCI-H719 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX6TWM2OD1yLkm2OlU4KM7:TR?= NEOxXpNUSU6JRWK=
SF539 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDnTWM2OD1yLkm4N|k3KM7:TR?= MmHNV2FPT0WU
NKM-1 NFTDZnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PUOmlEPTB;MD65PFY3OyEQvF2= MXHTRW5ITVJ?
A253 Mn7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHrNpA5UUN3ME2wMlk5QDh3IN88US=> M2fMTXNCVkeHUh?=
TE-441-T M1PCSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Szd2lEPTB;MT6wOFM2KM7:TR?= MXTTRW5ITVJ?
COR-L88 NInXVopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPBS3dKSzVyPUGuNVE{PTRizszN MW\TRW5ITVJ?
CPC-N NVLFTYVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFwMUW4PFgh|ryP MWrTRW5ITVJ?
NCI-H2107 NGfzS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jt[WlEPTB;MT6xO|I3OSEQvF2= MnvLV2FPT0WU
ECC4 M4jzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTFwMUi2PVMh|ryP NIXoZ5VUSU6JRWK=
NCI-H2141 M17vTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvqVXFJUUN3ME2xMlE6Ojl7IN88US=> NYLuWWxtW0GQR1XS
NCI-H1770 NV[2WIxET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nPd2lEPTB;MT6zNlkzQCEQvF2= NHTQPYpUSU6JRWK=
NCI-SNU-1 NUW4RpI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFwM{OwOEDPxE1? MV;TRW5ITVJ?
LU-165 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIX2OoZKSzVyPUGuOFU1PjdizszN MnrKV2FPT0WU
Raji NYOxVlJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPZcmxKSzVyPUGuOFczPTlizszN NHW2coNUSU6JRWK=
EW-24 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD0XmxVUUN3ME2xMlU1PjF7IN88US=> NUHjO5M{W0GQR1XS
KP-N-RT-BM-1 NGSwR2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILaUoxKSzVyPUGuOVY2PTFizszN NGm5bmxUSU6JRWK=
SK-MEL-1 M3zXeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\vO2lEPTB;MT62OFg4PyEQvF2= MWLTRW5ITVJ?
SCLC-21H Ml3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\RS2lEPTB;MT62OlY2OSEQvF2= MoezV2FPT0WU
SIMA MoPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT3ZmpKSzVyPUGuOlgzOzNizszN M{\JZXNCVkeHUh?=
NCI-H1304 MkPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTFwN{C3OlUh|ryP MYXTRW5ITVJ?
REH M2DzVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnPVIVUUUN3ME2xMlcyODd6IN88US=> NIDESWRUSU6JRWK=
KP-N-YS NG\3fIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGeyUGFKSzVyPUGuPVM2PTFizszN NXL4N3N2W0GQR1XS
DMS-153 NXvUZVFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\1TWM2OD1zLkm3OVkh|ryP M4PxcnNCVkeHUh?=
NB10 NYrURVhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP6TmRYUUN3ME2yMlIxQDd6IN88US=> Mn30V2FPT0WU
NCI-H345 NV7kZ2dPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHNTWM2OD1{Lk[xPVA2KM7:TR?= M2\nOnNCVkeHUh?=
SK-N-FI NHHTbZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjWTWM2OD1{Lke1N|gyKM7:TR?= MVHTRW5ITVJ?
NCI-H1092 NHfjWllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDTTWM2OD1{Lkm1N|k1KM7:TR?= M3;oSXNCVkeHUh?=
KM-H2 M4[yemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fwT2lEPTB;Mz62OVM6PiEQvF2= M3LNOnNCVkeHUh?=
KG-1 NYnvNllNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzsVHQzUUN3ME2zMlcyPjh6IN88US=> Mk\WV2FPT0WU
D-283MED MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HkPGlEPTB;Mz63OVg4KM7:TR?= Mn7BV2FPT0WU
LU-65 NV\hc|ZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjWZ4JLUUN3ME20MlEyPDh3IN88US=> NFqxcIVUSU6JRWK=
MSTO-211H MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTRwMUi4PVgh|ryP MVfTRW5ITVJ?
NCI-H2081 M3;FSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPmTWM2OD12LkK5NVc1KM7:TR?= Ml3xV2FPT0WU
D-247MG MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jUNWlEPTB;ND60N|E6OSEQvF2= MYjTRW5ITVJ?
P31-FUJ M4juT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTRwNEWwNVkh|ryP MUPTRW5ITVJ?
DMS-79 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTRwOUOxPFMh|ryP NVXRRVBMW0GQR1XS
KASUMI-1 M4fMeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTRwOUe1NFkh|ryP MlPQV2FPT0WU
JVM-3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;hR5VKSzVyPUWuNlUxOTRizszN MYLTRW5ITVJ?
LAN-6 MnHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfSTWM2OD13LkWxO|M3KM7:TR?= NFzsd2ZUSU6JRWK=
DJM-1 M{GyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3hSlNKSzVyPUWuOVYxOjlizszN M17oTXNCVkeHUh?=
JVM-2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LofmlEPTB;NT62O|A6OiEQvF2= MYLTRW5ITVJ?
U-87-MG NHTwT|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnVZm5qUUN3ME21Mlg6QTZ2IN88US=> Ml33V2FPT0WU
SHP-77 NEXYc4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nkWWlEPTB;NT65OFkzQCEQvF2= NH\VcmJUSU6JRWK=
RPMI-8866 NXvFS4dnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTZwMkewNVMh|ryP NICyeXRUSU6JRWK=
ES7 NWrZNIJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLCT|FKSzVyPU[uN|k6OjRizszN MYPTRW5ITVJ?
WSU-NHL NFzWPWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vXd2lEPTB;Nj61NVYxQSEQvF2= MV;TRW5ITVJ?
CAS-1 MmXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fXSWlEPTB;Nz6wPVc1QSEQvF2= NHv5VGlUSU6JRWK=
MHH-NB-11 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjWbYdKSzVyPUiuNlMyPTJizszN NW[xVWtPW0GQR1XS
ES5 NIDqcW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYWwfWxPUUN3ME25MlUzOjh4IN88US=> M{XZXHNCVkeHUh?=
HDLM-2 NWXk[Y1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTlwOUW5NFIh|ryP MnH0V2FPT0WU
NCI-H2171 M3n1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTFyLkW5Nlch|ryP M2HXO3NCVkeHUh?=
LNCaP-Clone-FGC MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTFzLkO3NVgh|ryP NGrGOlZUSU6JRWK=
NCI-H1395 NYLGdIZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mor1TWM2OD1zMj6yOlk6KM7:TR?= NGnrSFBUSU6JRWK=
NCI-H1436 NITwTYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHIRmlKSzVyPUGzMlMyQTVizszN NGrUTHpUSU6JRWK=
RCC10RGB NH7KVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4K3fWlEPTB;MUOuN|IzOSEQvF2= M1Pib3NCVkeHUh?=
SW684 NHLicHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PU[mlEPTB;MUOuPVc6PyEQvF2= NYLtZ5FNW0GQR1XS
NCI-H1650 NVfWS|BHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXrTWM2OD1zNT6wOFQ4KM7:TR?= NUPiTHAxW0GQR1XS
EW-13 MlOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTF3LkKwNlEh|ryP NIjYRZhUSU6JRWK=
EC-GI-10 NVLBOFFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTF3Lki2OFQh|ryP Mn\0V2FPT0WU
CHP-126 M2DUOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnNN3ZsUUN3ME2xO{4yQTF6IN88US=> NYPNbGVrW0GQR1XS
NCI-H226 NILpWoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLxNGRIUUN3ME2xPE4xPDB|IN88US=> NWG3N5loW0GQR1XS
NCI-H1838 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Lp[mlEPTB;MkCuNVg1QCEQvF2= NWmzfnhmW0GQR1XS
EW-11 NH;rXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJ2LkK3NVgh|ryP M2nCVXNCVkeHUh?=
EB2 NIL3WpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLQcXpKSzVyPUOxMlU{OThizszN NWnjZVRwW0GQR1XS
D-502MG M1S3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PkfGlEPTB;NEOuPVIzQSEQvF2= M2HPdnNCVkeHUh?=
U-698-M MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTR6Lki2O|Eh|ryP NEfkWYFUSU6JRWK=
ES3 NHfxeGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULNcGZWUUN3ME20PU4{QDl|IN88US=> NWq1[lZkW0GQR1XS

... Click to View More Cell Line Experimental Data

体内研究 Torin1在20 mg/kg剂量下,在U87MG异种移植模型中是有效的,并且在肿瘤和外周组织中对mTOR下游效应蛋白表现出良好的药效学抑制作用。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

mTORC1和 mTORC2体外激酶试验:

为产生可溶性mTORC1,HEK-293T细胞系,稳定表达N端FLAG标记的Raptor,使用水泡性口炎病毒G-假型病毒MSCV逆转录酶病毒产生。对于mTORC2,产生相似的HeLa细胞,能够稳定表达N端FLAG-标记的Protor-1。两个复合物通过在50 mm HEPES,pH 7.4,10 mm 焦磷酸钠,10 mm β-甘油磷酸钠,100 mm NaCl,2 mm EDTA,0.3% CHAPS中裂解细胞纯化。细胞在4 °C下裂解30分钟,不溶解部分通过以13,000 rpm微量离心10分钟移除。上清液与FLAG-M2单克隆抗体-琼脂糖培育1小时,然后用裂解缓冲液洗涤3次,用包含终浓度0.5 M NaCl的裂解缓冲液洗涤1次。纯化的mTORC1用100 μg/mL 3×FLAG多肽在50 mm HEPES,pH 7.4,100 mm NaCl中洗脱。将洗出液等分收集,储存在-80 °C。纯化底物S6K1 和 Akt1。激酶试验在30 °C,由激酶缓冲液(25 mm HEPES,pH 7.4,50 mm KCl,10 mm MgCl2,500 μm ATP)和150 ng 灭活的S6K1或Akt1底物组成的20 μL终体积混合物中进行。反应通过加入80 μL样品缓冲液停止,并沸煮5分钟。随后,样品通过SDS-PAGE和免疫印迹法分析。
细胞实验:[1]
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  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4天
  • Method: 细胞活性通过CellTiter-Glo发光法细胞活性测定评估。在第0天,细胞以500细胞每孔接种到96孔板,并生长过夜。第1天,细胞用适当的化合物处理,随后在第3-5天分析。对于分析,板在室温下培育60分钟,将50 μL CellTiter-Glo试剂加入每孔中,板在定轨摇床上混合12分钟。发光在标准平板光度计上定量。
    (Only for Reference)
动物实验:[2]
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  • Animal Models: U87MG 异种移植物模型
  • Formulation: Torin1粉末首先以25 mg/mL在100% N-甲基-2-吡咯烷酮中溶解,随后以1:4 与无菌 50% PEG400稀释到5 mg/mL的终浓度
  • Dosages: 20 mg/kg
  • Administration: 腹腔注射给药,每天一次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品:
20% NMP+50% PEG 400
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 607.62
化学式

C35H28F3N5O2

CAS号 1222998-36-8
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    How to re-constitute the inhibitor for i.p. administration?

  • 回答:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID