Torin 1

目录号:S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。

规格 价格 库存 购买数量  
RMB 1419.84 现货
RMB 3019.04 现货
RMB 5492.28 现货
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客户使用该产品的4个实验数据:

  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

产品安全说明书

mTOR抑制剂选择性比较

生物活性

产品描述 Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。
靶点
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
体外研究

Torin1在2和10 nM浓度下分别抑制mTORC1 和mTORC2底物的磷酸化。此外,Torin1对mTOR比对PI3K (EC50 = 1800 nM)的选择性高1000倍,比对450种其它蛋白激酶的结合选择性高100倍。[1] [2] Torin1通过耐rapamycin机制引起细胞周期阻滞,并且其不依赖于mTORC2。Torin1比rapamycin更完全地干扰mTORC1依赖表现型。Cap依赖性翻译需要mTORC1耐Rapamycin的功能。[1]在近期的一项研究中,据报道Torin1通过活化人内分泌细胞系BON 中MEK/ERK/c-Jun通路,能够增加神经降压素分泌和基因表达。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 NHrHTFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn0TWM2OD1yLkCwNFMxPiEQvF2= NV:zUFVUW0GQR1XS
OCUB-M NXHwdItNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPsN4ZKSzVyPUCuNFAyQTRizszN M3vleHNCVkeHUh?=
DOHH-2 Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\1V2hKSzVyPUCuNFAzOjVizszN MofDV2FPT0WU
NOS-1 MlmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz4TWM2OD1yLkCwNlQzKM7:TR?= NXrpd2RFW0GQR1XS
L-363 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\2TWM2OD1yLkCwNlg1KM7:TR?= Mn;VV2FPT0WU
RL95-2 NWK0dGJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\6T3RjUUN3ME2wMlAxOzJizszN MYfTRW5ITVJ?
BL-70 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XFSmlEPTB;MD6wNFM{PyEQvF2= M4TVb3NCVkeHUh?=
TGBC1TKB NF[1[mlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1y1PWlEPTB;MD6wNFM4QSEQvF2= NUTPN|BnW0GQR1XS
697 NHzMWIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYn4XnpVUUN3ME2wMlAxPjN2IN88US=> M3z5WHNCVkeHUh?=
RPMI-8226 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3ORmFQUUN3ME2wMlAxPjVzIN88US=> M1P0SHNCVkeHUh?=
BL-41 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn2TWM2OD1yLkCwOlk3KM7:TR?= NGTlbYFUSU6JRWK=
MRK-nu-1 NHrwXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHoW45KSzVyPUCuNFA4ODdizszN MmDBV2FPT0WU
EW-1 NETFfWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEC3OFkh|ryP MXnTRW5ITVJ?
EVSA-T MkDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEC4PVIh|ryP NX;vZVdxW0GQR1XS
HUTU-80 M2\NVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMEC5Nlkh|ryP M161VHNCVkeHUh?=
VA-ES-BJ MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nXNGlEPTB;MD6wNFk5PCEQvF2= MkDQV2FPT0WU
GCIY NIP3NWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYX1fpc6UUN3ME2wMlAyODB5IN88US=> MUDTRW5ITVJ?
ES6 NUTrW|l2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LP[mlEPTB;MD6wNVA5OyEQvF2= NIjORW5USU6JRWK=
NALM-6 NVfvPG9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXT[|hKSzVyPUCuNFEyODJizszN M2DPU3NCVkeHUh?=
LB996-RCC M{X3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLpUIlHUUN3ME2wMlAyOTN5IN88US=> NHnNenFUSU6JRWK=
EW-16 MnjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEGxPVIh|ryP NVTLUII6W0GQR1XS
KALS-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMEGxPVgh|ryP MWHTRW5ITVJ?
OPM-2 Ml;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHaTWM2OD1yLkCxNlkh|ryP MUfTRW5ITVJ?
KU812 MnHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TSXmlEPTB;MD6wNVI6PiEQvF2= NE\UV41USU6JRWK=
A4-Fuk MkPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXSW3NLUUN3ME2wMlAyOzF7IN88US=> M4jwNnNCVkeHUh?=
KGN MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHTcIlKSzVyPUCuNFE{PTlizszN M4j4SnNCVkeHUh?=
KS-1 NUnGWWp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2P6R2lEPTB;MD6wNVM6OiEQvF2= MXjTRW5ITVJ?
no-11 NHzXc|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;uOWlEPTB;MD6wNVM6PSEQvF2= MUXTRW5ITVJ?
PSN1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjHWWRnUUN3ME2wMlAyPDB7IN88US=> NGTyNllUSU6JRWK=
SK-LMS-1 MkCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH61NGRKSzVyPUCuNFE1OTNizszN NGHH[WtUSU6JRWK=
LS-411N NX;2cWpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEG0N|kh|ryP M4Xvd3NCVkeHUh?=
HT-144 M4i4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMEG0OVEh|ryP NF\CdW9USU6JRWK=
ACN MnjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\HOIhTUUN3ME2wMlAyPSEQvF2= Mo\aV2FPT0WU
RKO NHPSN2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfSbnFRUUN3ME2wMlAyPTN|IN88US=> NYLIO5ZlW0GQR1XS
CMK Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rtc2lEPTB;MD6wNVU1OyEQvF2= M1nzbnNCVkeHUh?=
GB-1 Mn\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon0TWM2OD1yLkCxOVU{KM7:TR?= M1LCUXNCVkeHUh?=
KE-37 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjFTWM2OD1yLkCxOVc{KM7:TR?= MVvTRW5ITVJ?
no-10 Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMEG1PFQh|ryP NFLiZZNUSU6JRWK=
MOLT-16 M{DCVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvjTWM2OD1yLkCxOlIzKM7:TR?= NX7M[nh3W0GQR1XS
HEL MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m3O2lEPTB;MD6wNVY1KM7:TR?= MWXTRW5ITVJ?
NCI-H1355 NUjBOWZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe0TWM2OD1yLkCxOlQ3KM7:TR?= MXrTRW5ITVJ?
IST-MEL1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjUU4hKSzVyPUCuNFE4PzRizszN MofOV2FPT0WU
MHH-PREB-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWqyS4t6UUN3ME2wMlAyQDF6IN88US=> NVG4UGNZW0GQR1XS
ES8 MonTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMEG4OFQh|ryP MnPTV2FPT0WU
LC-2-ad NH\NSnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMEKxN|ch|ryP Mn3KV2FPT0WU
LAMA-84 M4LwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\PTWM2OD1yLkCyNVY4KM7:TR?= MkLoV2FPT0WU
BV-173 M1i0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHr0ZoZKSzVyPUCuNFIzODNizszN MWDTRW5ITVJ?
SW872 MnTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlK5TWM2OD1yLkCyNlQ4KM7:TR?= M4P6VXNCVkeHUh?=
SK-UT-1 NFfKT3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfmVIVKSzVyPUCuNFIzPjFizszN M3TmcXNCVkeHUh?=
OS-RC-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEKzNlMh|ryP MV;TRW5ITVJ?
NCI-H747 NHewd49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMEKzN{DPxE1? MX;TRW5ITVJ?
MZ2-MEL NFPTXllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEKzN|ch|ryP MlriV2FPT0WU
TE-11 M4rkb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX36e3N{UUN3ME2wMlAzOzd{IN88US=> NEmzS5JUSU6JRWK=
KURAMOCHI MnnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XsT2lEPTB;MD6wNlQyPCEQvF2= MWnTRW5ITVJ?
HD-MY-Z MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPOc5VIUUN3ME2wMlAzPDJ4IN88US=> MVXTRW5ITVJ?
GI-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2noRWlEPTB;MD6wNlQ3QSEQvF2= NV\TXIZDW0GQR1XS
LB1047-RCC NYrkXFE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nOSmlEPTB;MD6wNlQ5QCEQvF2= MoDmV2FPT0WU
TE-12 Mmi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;hfW5PUUN3ME2wMlAzPTVizszN MWrTRW5ITVJ?
MZ7-mel NF\HVYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEK2NFkh|ryP M{ize3NCVkeHUh?=
MMAC-SF MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LBTmlEPTB;MD6wNlY{OyEQvF2= M{C4cXNCVkeHUh?=
A101D MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEK2OUDPxE1? Mo\kV2FPT0WU
GR-ST M1\QSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHMTWM2OD1yLkCyOlU2KM7:TR?= NWXsXJo{W0GQR1XS
MC116 M1ztXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\sXGlEPTB;MD6wNlY5KM7:TR?= NEK3U2xUSU6JRWK=
Ramos-2G6-4C10 NVKx[Wg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPhUXJKSzVyPUCuNFI4PSEQvF2= M1n0fHNCVkeHUh?=
ATN-1 M4frOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLTTWM2OD1yLkCyO|g6KM7:TR?= NY\YbYlZW0GQR1XS
MFH-ino NW\NNFdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEK4NVIh|ryP MkjKV2FPT0WU
DEL NXfiUnFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEK4NVUh|ryP MmLnV2FPT0WU
OCI-AML2 NVjtWFlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEK4O|Eh|ryP MUXTRW5ITVJ?
LXF-289 NWi1XnRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEK4O|Ih|ryP NUGydHQ5W0GQR1XS
IA-LM M4m0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTHfoFKSzVyPUCuNFI6OTdizszN NFq3RYFUSU6JRWK=
EoL-1-cell NEDrNnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rrUmlEPTB;MD6wNlk6PiEQvF2= NILvZYlUSU6JRWK=
OVCAR-4 NV3vPHRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzTOnZKSzVyPUCuNFMxQTRizszN M1HtRnNCVkeHUh?=
ES1 NXvOPG5rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfNUWxKSzVyPUCuNFMxQTdizszN M4TTPHNCVkeHUh?=
CESS NF;WUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3f5RWlEPTB;MD6wN|A6QSEQvF2= M4\VZnNCVkeHUh?=
GAK NYKyV2J{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUW4fot6UUN3ME2wMlA{OTh4IN88US=> NV20OZpnW0GQR1XS
NTERA-S-cl-D1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnHT2ZsUUN3ME2wMlA{OjJ4IN88US=> NVLhcmZ7W0GQR1XS
TE-10 Mm\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fwN2lEPTB;MD6wN|MyOSEQvF2= M135OXNCVkeHUh?=
CCRF-CEM Mm\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDqVllLUUN3ME2wMlA{OzdzIN88US=> MVjTRW5ITVJ?
NMC-G1 MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUH3eGgxUUN3ME2wMlA{PDR6IN88US=> M1nNbHNCVkeHUh?=
HOP-62 NXPWVIFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMEO1OVYh|ryP MkTpV2FPT0WU
SH-4 NITpV|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLHUYp7UUN3ME2wMlA{PTh{IN88US=> MXHTRW5ITVJ?
NCI-H1648 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEO2NlIh|ryP MYPTRW5ITVJ?
EB-3 NVHFVnVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMEO2OFMh|ryP M3H0TnNCVkeHUh?=
BB65-RCC NF64OGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;0d2lEPTB;MD6wN|Y6OSEQvF2= NYW1[pRGW0GQR1XS
BE-13 NUnxfZppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEO3OVkh|ryP MojZV2FPT0WU
CP67-MEL NEDYPFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMEO3OVkh|ryP NHXKeZlUSU6JRWK=
SW954 NVv2SWhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PGWGlEPTB;MD6wN|c6KM7:TR?= MoSwV2FPT0WU
TE-5 MmnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzUTWM2OD1yLkCzPFU1KM7:TR?= M3zDUHNCVkeHUh?=
HCE-4 Mnm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7YSJBKSzVyPUCuNFM5PTVizszN MXXTRW5ITVJ?
LC-1F M1m5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMEO5PFkh|ryP M1\rPXNCVkeHUh?=
TK10 NH7Z[oRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMESwNVkh|ryP NVv0c2xMW0GQR1XS
SJSA-1 NEPJVoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMESxPFgh|ryP MkL0V2FPT0WU
Daudi MlvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMESyNlUh|ryP Mly0V2FPT0WU
SW982 Mk[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXIXnhyUUN3ME2wMlA1OjR4IN88US=> NGW2bIZUSU6JRWK=
SF126 NU\w[Xo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DW[mlEPTB;MD6wOFM3OSEQvF2= NYXve|NKW0GQR1XS
TE-15 MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX4WlhSUUN3ME2wMlA1PDN3IN88US=> NH\2doNUSU6JRWK=
COLO-684 NV:zUFZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPTTWM2OD1yLkC0OVYyKM7:TR?= M{fCdnNCVkeHUh?=
8-MG-BA MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPo[nQ2UUN3ME2wMlA1PjJ7IN88US=> NILUU5BUSU6JRWK=
NB13 MkTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLxTWM2OD1yLkC0O|c3KM7:TR?= NFP2NpRUSU6JRWK=
HCC1599 M{HHPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFO5WWhKSzVyPUCuNFQ5PzlizszN MXXTRW5ITVJ?
SK-PN-DW NWnPc3BUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXlZnJKSzVyPUCuNFQ6PDlizszN NFjseGxUSU6JRWK=
ALL-PO M2XCZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInienlKSzVyPUCuNFQ6PTZizszN NEHy[oxUSU6JRWK=
NB6 NVy3VnV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:zc2lEPTB;MD6wOVI4OSEQvF2= NH;PO3VUSU6JRWK=
IST-SL2 M{jGXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojRTWM2OD1yLkC1N|YzKM7:TR?= NGPWRpJUSU6JRWK=
BB30-HNC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjqWoVKSzVyPUCuNFU4OyEQvF2= M2XteHNCVkeHUh?=
SW962 M1jkV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEW3OlMh|ryP NV21VoFqW0GQR1XS
TGBC24TKB M3y4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXDT2hEUUN3ME2wMlA2Pzl7IN88US=> NWezO45LW0GQR1XS
KINGS-1 NWnZZnVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jRZ2lEPTB;MD6wOVgxOyEQvF2= MmfZV2FPT0WU
HC-1 Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nrNWlEPTB;MD6wOVgzPyEQvF2= MlG3V2FPT0WU
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GDM-1 MlPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfHTWM2OD1yLkO3NlM1KM7:TR?= M3n4fnNCVkeHUh?=
TGW MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rZXWlEPTB;MD6zO|Q2OyEQvF2= MV\TRW5ITVJ?
SNU-C1 Mnq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rSU2lEPTB;MD6zPFIyPSEQvF2= NXTM[WFjW0GQR1XS
LS-513 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwM{mwO|Eh|ryP MmntV2FPT0WU
NOMO-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTUTWM2OD1yLkO5PVcyKM7:TR?= NYfRWZdYW0GQR1XS
MS-1 NI[zNHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zuXWlEPTB;MD60NFE4PyEQvF2= NI[5dYtUSU6JRWK=
EKVX MlLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXpTWM2OD1yLkS0OFYyKM7:TR?= MXjTRW5ITVJ?
SK-MEL-2 M4S0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\mO2tlUUN3ME2wMlQ3PCEQvF2= M{DRbXNCVkeHUh?=
HCC1187 NFjpSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j3d2lEPTB;MD60Olc3QCEQvF2= MVPTRW5ITVJ?
HCC2218 Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHERXFKSzVyPUCuOFczOjdizszN NGLXSXNUSU6JRWK=
NCI-H187 NH\JVVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwNEe4OEDPxE1? MWLTRW5ITVJ?
DB MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjSTWM2OD1yLkWwNFU2KM7:TR?= NHjWSVdUSU6JRWK=
NCI-H69 MoPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NID0XZZKSzVyPUCuOVAzPDdizszN NFezVZhUSU6JRWK=
NCI-H1694 NWnqNXM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHNTWM2OD1yLkWwOlk4KM7:TR?= NF2ydFhUSU6JRWK=
CA46 M3T4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfDTFNKSzVyPUCuOVA6OTdizszN MUfTRW5ITVJ?
EHEB M1L2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3mye2lEPTB;MD61NVE6OyEQvF2= MXTTRW5ITVJ?
NCCIT MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwNUSzNlEh|ryP NXPLNG5QW0GQR1XS
NCI-H720 Mln4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorKTWM2OD1yLkW0PVYzKM7:TR?= MoThV2FPT0WU
LU-134-A NH7QSmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTPdm9KSzVyPUCuOVUzQTZizszN MUDTRW5ITVJ?
MC-CAR MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTYTWM2OD1yLkW1OFMyKM7:TR?= NGS4UVlUSU6JRWK=
NEC8 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjjZ2FKSzVyPUCuOVYyPzJizszN M4PVfnNCVkeHUh?=
NCI-H524 MkfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDwenZKSzVyPUCuOVg4PDhizszN MYjTRW5ITVJ?
NCI-H1963 NXPMWnR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwNkK1PEDPxE1? MUfTRW5ITVJ?
SU-DHL-1 NYT3[ohbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwNkS1NlYh|ryP MWXTRW5ITVJ?
NCI-H1522 MkO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXyxcYpUUUN3ME2wMlY1QDh|IN88US=> M4O4[3NCVkeHUh?=
NCI-H1155 MmW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLlTWM2OD1yLk[1N|Uh|ryP MmPsV2FPT0WU
D-263MG M2PWVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXCTWM2OD1yLk[2NVAyKM7:TR?= M2G0eHNCVkeHUh?=
TE-6 M{fEU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XjNWlEPTB;MD62PFExPCEQvF2= M2POV3NCVkeHUh?=
NCI-H1417 NHntWZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYK2PVdWUUN3ME2wMlY6PzFzIN88US=> NYH6RW1pW0GQR1XS
NCI-H510A NUDiV3IxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzJTWM2OD1yLke3NlM3KM7:TR?= M2W3eHNCVkeHUh?=
KARPAS-45 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHxTWM2OD1yLke4NlM2KM7:TR?= NYnjZY55W0GQR1XS
IST-SL1 NV6zT4VbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDvUplEUUN3ME2wMlg2QDJ3IN88US=> MYPTRW5ITVJ?
COLO-824 M1vNeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHj0WmJKSzVyPUCuPFc5OzVizszN NVzDVopDW0GQR1XS
NCI-H526 M160UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPhTWM2OD1yLkmwPVU5KM7:TR?= MWHTRW5ITVJ?
NCI-H719 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;BTWM2OD1yLkm2OlU4KM7:TR?= MlLiV2FPT0WU
SF539 M{fyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjvW|FKSzVyPUCuPVg{QTZizszN NHLSNXNUSU6JRWK=
NKM-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwOUi2OlMh|ryP MnPJV2FPT0WU
A253 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTYTWM2OD1yLkm4PFg2KM7:TR?= NILMU4NUSU6JRWK=
TE-441-T NILycWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPMO2RWUUN3ME2xMlA1OzVizszN NVu4XGRpW0GQR1XS
COR-L88 NFXSNHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTFwMUGzOVQh|ryP M1jpPXNCVkeHUh?=
CPC-N NEL1[mVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDTTWM2OD1zLkG1PFg5KM7:TR?= NHT3bIxUSU6JRWK=
NCI-H2107 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljlTWM2OD1zLkG3NlYyKM7:TR?= MmfXV2FPT0WU
ECC4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHWTWM2OD1zLkG4Olk{KM7:TR?= M{nJNXNCVkeHUh?=
NCI-H2141 NX7zNWh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWO0NJY{UUN3ME2xMlE6Ojl7IN88US=> NHHxSmJUSU6JRWK=
NCI-H1770 MkT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXsTWM2OD1zLkOyPVI5KM7:TR?= MXfTRW5ITVJ?
NCI-SNU-1 Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnMV4VKSzVyPUGuN|MxPCEQvF2= NHLaXVFUSU6JRWK=
LU-165 NI[1SItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV6x[o05UUN3ME2xMlQ2PDZ5IN88US=> MnvNV2FPT0WU
Raji MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vDe2lEPTB;MT60O|I2QSEQvF2= MnTwV2FPT0WU
EW-24 MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTFwNUS2NVkh|ryP MUfTRW5ITVJ?
KP-N-RT-BM-1 M{fHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFwNU[1OVEh|ryP MYXTRW5ITVJ?
SK-MEL-1 MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fmXWlEPTB;MT62OFg4PyEQvF2= NGHnbHpUSU6JRWK=
SCLC-21H MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3jTWM2OD1zLk[2OlUyKM7:TR?= M2r4c3NCVkeHUh?=
SIMA M3\xfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrHXmFzUUN3ME2xMlY5OjN|IN88US=> M13zV3NCVkeHUh?=
NCI-H1304 NVfGNnR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nmTWlEPTB;MT63NFc3PSEQvF2= MWXTRW5ITVJ?
REH NFrD[VVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof0TWM2OD1zLkexNFc5KM7:TR?= NY\2Nnc4W0GQR1XS
KP-N-YS MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mke2TWM2OD1zLkmzOVUyKM7:TR?= NUC5WZQ5W0GQR1XS
DMS-153 MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTkXWpRUUN3ME2xMlk4PTlizszN MmOzV2FPT0WU
NB10 MkXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF35UJlKSzVyPUKuNlA5PzhizszN NEDJeGZUSU6JRWK=
NCI-H345 NWnXfY5NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX0VnlbUUN3ME2yMlYyQTB3IN88US=> M{\1[XNCVkeHUh?=
SK-N-FI MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLtTWM2OD1{Lke1N|gyKM7:TR?= NIfTXIZUSU6JRWK=
NCI-H1092 MoH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\2UmlEPTB;Mj65OVM6PCEQvF2= MVHTRW5ITVJ?
KM-H2 NGqxb3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTNwNkWzPVYh|ryP M3rxeHNCVkeHUh?=
KG-1 NX7oZ2pLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzkTWM2OD1|LkexOlg5KM7:TR?= M2fqdnNCVkeHUh?=
D-283MED NUTIVnFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTNwN{W4O{DPxE1? MX\TRW5ITVJ?
LU-65 M1;vXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXtemhKSzVyPUSuNVE1QDVizszN M{K2VnNCVkeHUh?=
MSTO-211H NFvjcZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTRwMUi4PVgh|ryP M12wWHNCVkeHUh?=
NCI-H2081 NXu1[XRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7OWHlKSzVyPUSuNlkyPzRizszN NWPlWVVXW0GQR1XS
D-247MG MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvyTWM2OD12LkSzNVkyKM7:TR?= M{\PcXNCVkeHUh?=
P31-FUJ NHLON2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\kcG54UUN3ME20MlQ2ODF7IN88US=> M{DRc3NCVkeHUh?=
DMS-79 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLGTWM2OD12LkmzNVg{KM7:TR?= M3fMc3NCVkeHUh?=
KASUMI-1 NXPIXm17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TLfmlEPTB;ND65O|UxQSEQvF2= NXLsWXh6W0GQR1XS
JVM-3 NVPHcHA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTVwMkWwNVQh|ryP M4rPSXNCVkeHUh?=
LAN-6 M{T2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DZUGlEPTB;NT61NVc{PiEQvF2= MlrlV2FPT0WU
DJM-1 NVPze45{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTVwNU[wNlkh|ryP MYLTRW5ITVJ?
JVM-2 MmTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\NPY1QUUN3ME21MlY4ODl{IN88US=> NGTlUpZUSU6JRWK=
U-87-MG NWjheVh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;KfIZKSzVyPUWuPFk6PjRizszN MmPrV2FPT0WU
SHP-77 NInpXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Tud2lEPTB;NT65OFkzQCEQvF2= NXrs[HI6W0GQR1XS
RPMI-8866 NHLPeItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXuw[ZNpUUN3ME22MlI4ODF|IN88US=> NVfHcllMW0GQR1XS
ES7 NX7LWnJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTZwM{m5NlQh|ryP MnjtV2FPT0WU
WSU-NHL NIXFRXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDjT3VKSzVyPU[uOVE3ODlizszN NXSxbW9uW0GQR1XS
CAS-1 M37PeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLOSGlOUUN3ME23MlA6PzR7IN88US=> MUHTRW5ITVJ?
MHH-NB-11 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M36xcmlEPTB;OD6yN|E2OiEQvF2= NUDFUVdNW0GQR1XS
ES5 Ml;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXqVIFHUUN3ME25MlUzOjh4IN88US=> MornV2FPT0WU
HDLM-2 NHPpfXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvieVNKSzVyPUmuPVU6ODJizszN Ml\NV2FPT0WU
NCI-H2171 Mn32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HDZ2lEPTB;MUCuOVkzPyEQvF2= NFjIPG9USU6JRWK=
LNCaP-Clone-FGC MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XrdmlEPTB;MUGuN|cyQCEQvF2= Mnj5V2FPT0WU
NCI-H1395 MnSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDETWM2OD1zMj6yOlk6KM7:TR?= NYTMblJMW0GQR1XS
NCI-H1436 NGHsVIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF|LkOxPVUh|ryP MoXwV2FPT0WU
RCC10RGB NX;OUnBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTF|LkOyNlEh|ryP MVzTRW5ITVJ?
SW684 M{DKeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXewcol7UUN3ME2xN{46Pzl5IN88US=> Mn\qV2FPT0WU
NCI-H1650 MoHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvhTWM2OD1zNT6wOFQ4KM7:TR?= NIDHOVlUSU6JRWK=
EW-13 M1T5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fXRWlEPTB;MUWuNlAzOSEQvF2= MmjTV2FPT0WU
EC-GI-10 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe5bWJKSzVyPUG1Mlg3PDRizszN MVzTRW5ITVJ?
CHP-126 NVXDXYc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7NTWM2OD1zNz6xPVE5KM7:TR?= Mm\pV2FPT0WU
NCI-H226 NUD2NJFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DwSmlEPTB;MUiuNFQxOyEQvF2= M3XoNHNCVkeHUh?=
NCI-H1838 MonIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLuTWM2OD1{MD6xPFQ5KM7:TR?= NIe5d2FUSU6JRWK=
EW-11 NXG0XnNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\2VGlEPTB;MkSuNlcyQCEQvF2= NFr5fXpUSU6JRWK=
EB2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnRWHVKSzVyPUOxMlU{OThizszN NIPa[GtUSU6JRWK=
D-502MG MnW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\DbGlEPTB;NEOuPVIzQSEQvF2= NFLNZXRUSU6JRWK=
U-698-M M4nFfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7BNJVUUUN3ME20PE45PjdzIN88US=> M{Pyd3NCVkeHUh?=
ES3 M2W0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTR7LkO4PVMh|ryP MmL6V2FPT0WU

... Click to View More Cell Line Experimental Data

体内研究 Torin1在20 mg/kg剂量下,在U87MG异种移植模型中是有效的,并且在肿瘤和外周组织中对mTOR下游效应蛋白表现出良好的药效学抑制作用。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

mTORC1和 mTORC2体外激酶试验:

为产生可溶性mTORC1,HEK-293T细胞系,稳定表达N端FLAG标记的Raptor,使用水泡性口炎病毒G-假型病毒MSCV逆转录酶病毒产生。对于mTORC2,产生相似的HeLa细胞,能够稳定表达N端FLAG-标记的Protor-1。两个复合物通过在50 mm HEPES,pH 7.4,10 mm 焦磷酸钠,10 mm β-甘油磷酸钠,100 mm NaCl,2 mm EDTA,0.3% CHAPS中裂解细胞纯化。细胞在4 °C下裂解30分钟,不溶解部分通过以13,000 rpm微量离心10分钟移除。上清液与FLAG-M2单克隆抗体-琼脂糖培育1小时,然后用裂解缓冲液洗涤3次,用包含终浓度0.5 M NaCl的裂解缓冲液洗涤1次。纯化的mTORC1用100 μg/mL 3×FLAG多肽在50 mm HEPES,pH 7.4,100 mm NaCl中洗脱。将洗出液等分收集,储存在-80 °C。纯化底物S6K1 和 Akt1。激酶试验在30 °C,由激酶缓冲液(25 mm HEPES,pH 7.4,50 mm KCl,10 mm MgCl2,500 μm ATP)和150 ng 灭活的S6K1或Akt1底物组成的20 μL终体积混合物中进行。反应通过加入80 μL样品缓冲液停止,并沸煮5分钟。随后,样品通过SDS-PAGE和免疫印迹法分析。
细胞实验:[1]
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  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4天
  • Method: 细胞活性通过CellTiter-Glo发光法细胞活性测定评估。在第0天,细胞以500细胞每孔接种到96孔板,并生长过夜。第1天,细胞用适当的化合物处理,随后在第3-5天分析。对于分析,板在室温下培育60分钟,将50 μL CellTiter-Glo试剂加入每孔中,板在定轨摇床上混合12分钟。发光在标准平板光度计上定量。
    (Only for Reference)
动物实验:[2]
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  • Animal Models: U87MG 异种移植物模型
  • Formulation: Torin1粉末首先以25 mg/mL在100% N-甲基-2-吡咯烷酮中溶解,随后以1:4 与无菌 50% PEG400稀释到5 mg/mL的终浓度
  • Dosages: 20 mg/kg
  • Administration: 腹腔注射给药,每天一次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
20% NMP+50% PEG 400
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 607.62
化学式

C35H28F3N5O2

CAS号 1222998-36-8
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    How to re-constitute the inhibitor for i.p. administration?

  • 回答:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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mTOR Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID