Torin 1

目录号:S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。

规格 价格 库存 购买数量  
RMB 1419.84 现货
RMB 3019.04 现货
RMB 5492.28 现货
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客户使用该产品的5个实验数据:

  • Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

    Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

  • Exp Cell Res, 2018, 363(1):84-94. Torin 1 purchased from Selleck.

    Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

  • Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

产品安全说明书

mTOR抑制剂选择性比较

生物活性

产品描述 Torin 1是一种有效的mTORC1/2抑制剂,在无细胞试验中IC50为2 nM/10 nM;作用于mTOR比作用于PI3K选择性高1000倍。
靶点
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
体外研究

Torin1在2和10 nM浓度下分别抑制mTORC1 和mTORC2底物的磷酸化。此外,Torin1对mTOR比对PI3K (EC50 = 1800 nM)的选择性高1000倍,比对450种其它蛋白激酶的结合选择性高100倍。[1] [2] Torin1通过耐rapamycin机制引起细胞周期阻滞,并且其不依赖于mTORC2。Torin1比rapamycin更完全地干扰mTORC1依赖表现型。Cap依赖性翻译需要mTORC1耐Rapamycin的功能。[1]在近期的一项研究中,据报道Torin1通过活化人内分泌细胞系BON 中MEK/ERK/c-Jun通路,能够增加神经降压素分泌和基因表达。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMECwN|A3KM7:TR?= M3nrOnNCVkeHUh?=
OCUB-M MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXvZlBKSzVyPUCuNFAyQTRizszN M1TNfXNCVkeHUh?=
DOHH-2 NUXnTGN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml71TWM2OD1yLkCwNlI2KM7:TR?= M36xTnNCVkeHUh?=
NOS-1 M1rR[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzlOHlKSzVyPUCuNFAzPDJizszN M{XaNXNCVkeHUh?=
L-363 NXj3VFVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfGfJVKSzVyPUCuNFAzQDRizszN MoXxV2FPT0WU
RL95-2 NXHER5ZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXhXXZFUUN3ME2wMlAxOzJizszN MorUV2FPT0WU
BL-70 MnfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\5c5BKSzVyPUCuNFA{OzdizszN MWLTRW5ITVJ?
TGBC1TKB NYfYenpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rHVGlEPTB;MD6wNFM4QSEQvF2= NInTOGVUSU6JRWK=
697 M1zEbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nlWmlEPTB;MD6wNFY{PCEQvF2= MVfTRW5ITVJ?
RPMI-8226 NYXReoJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4THZ2lEPTB;MD6wNFY2OSEQvF2= MX\TRW5ITVJ?
BL-41 NYDVWo5iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjqNm1KSzVyPUCuNFA3QTZizszN MmfxV2FPT0WU
MRK-nu-1 M2X1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIezW2RKSzVyPUCuNFA4ODdizszN MoPhV2FPT0WU
EW-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3MTWM2OD1yLkCwO|Q6KM7:TR?= NGnLbYtUSU6JRWK=
EVSA-T MljhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vzfWlEPTB;MD6wNFg6OiEQvF2= M1\yOHNCVkeHUh?=
HUTU-80 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzpTWM2OD1yLkCwPVI6KM7:TR?= MlP5V2FPT0WU
VA-ES-BJ NGP3TlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnToTWM2OD1yLkCwPVg1KM7:TR?= NEG2cG9USU6JRWK=
GCIY NIr3W5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fnfWlEPTB;MD6wNVAxPyEQvF2= MnL5V2FPT0WU
ES6 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;xSHJiUUN3ME2wMlAyODh|IN88US=> NH7BPIRUSU6JRWK=
NALM-6 NXXvfJJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml22TWM2OD1yLkCxNVAzKM7:TR?= NX3QXZlrW0GQR1XS
LB996-RCC NVzmVW02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEGxN|ch|ryP NX\aO2tTW0GQR1XS
EW-16 NYOycVZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWO0cYhoUUN3ME2wMlAyOTl{IN88US=> NXvsT5dvW0GQR1XS
KALS-1 NG\uUoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlS0TWM2OD1yLkCxNVk5KM7:TR?= NVHqeWlDW0GQR1XS
OPM-2 M3LqXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;nTGlEPTB;MD6wNVI6KM7:TR?= M1XBbHNCVkeHUh?=
KU812 NXHRWYV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrjPZJOUUN3ME2wMlAyOjl4IN88US=> NXnJbIcyW0GQR1XS
A4-Fuk NY\BXlVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEGzNVkh|ryP MWHTRW5ITVJ?
KGN NF3kTHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7VRnVKSzVyPUCuNFE{PTlizszN MkC4V2FPT0WU
KS-1 Ml\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITSe4ZKSzVyPUCuNFE{QTJizszN M2rqb3NCVkeHUh?=
no-11 NEm0fY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rqOWlEPTB;MD6wNVM6PSEQvF2= NVL6WHJRW0GQR1XS
PSN1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDZOW1KSzVyPUCuNFE1ODlizszN M4Di[3NCVkeHUh?=
SK-LMS-1 NH7o[YpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMEG0NVMh|ryP NX;3bYhGW0GQR1XS
LS-411N NH36WmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDBVnBKSzVyPUCuNFE1OzlizszN M{PEVnNCVkeHUh?=
HT-144 M4ToT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEG0OVEh|ryP MXPTRW5ITVJ?
ACN M1fENGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHi3eZhKSzVyPUCuNFE2KM7:TR?= M2TNVnNCVkeHUh?=
RKO NEPr[mpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnaUGJKSzVyPUCuNFE2OzNizszN MofVV2FPT0WU
CMK NGfXfJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjmR4ZKSzVyPUCuNFE2PDNizszN M3v1VnNCVkeHUh?=
GB-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMEG1OVMh|ryP M{W0W3NCVkeHUh?=
KE-37 MoewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfoNVlKSzVyPUCuNFE2PzNizszN NYLJfGVZW0GQR1XS
no-10 MnrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorFTWM2OD1yLkCxOVg1KM7:TR?= MVfTRW5ITVJ?
MOLT-16 NHPKfXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHtO5lKSzVyPUCuNFE3OjJizszN MWHTRW5ITVJ?
HEL MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMEG2OEDPxE1? M33XTXNCVkeHUh?=
NCI-H1355 Ml\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLKTWM2OD1yLkCxOlQ3KM7:TR?= MYHTRW5ITVJ?
IST-MEL1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGqxT|FKSzVyPUCuNFE4PzRizszN M4LNcnNCVkeHUh?=
MHH-PREB-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELvXFFKSzVyPUCuNFE5OThizszN NYPLVHBZW0GQR1XS
ES8 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMEG4OFQh|ryP MVnTRW5ITVJ?
LC-2-ad NH\WbWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPDXWtKSzVyPUCuNFIyOzdizszN M{XXXnNCVkeHUh?=
LAMA-84 MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn4V25KSzVyPUCuNFIyPjdizszN MWTTRW5ITVJ?
BV-173 NVPpOopGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HvTWlEPTB;MD6wNlIxOyEQvF2= MVTTRW5ITVJ?
SW872 MnmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7zTWM2OD1yLkCyNlQ4KM7:TR?= NXmyXYx[W0GQR1XS
SK-UT-1 MmLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrpTWM2OD1yLkCyNlYyKM7:TR?= M13rT3NCVkeHUh?=
OS-RC-2 MnL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj1bYhKSzVyPUCuNFI{OjNizszN M1;Xb3NCVkeHUh?=
NCI-H747 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEKzN{DPxE1? NV3wSnZtW0GQR1XS
MZ2-MEL NVzSXVFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHe5VGNKSzVyPUCuNFI{OzdizszN MYfTRW5ITVJ?
TE-11 NHTGU3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[1TWM2OD1yLkCyN|czKM7:TR?= NWnpR2ZLW0GQR1XS
KURAMOCHI NIjBbodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPvd4RKSzVyPUCuNFI1OTRizszN MXXTRW5ITVJ?
HD-MY-Z MmDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j1ZWlEPTB;MD6wNlQzPiEQvF2= NXTkdVBEW0GQR1XS
GI-1 NWT4XJRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlP1TWM2OD1yLkCyOFY6KM7:TR?= NEH2cXpUSU6JRWK=
LB1047-RCC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoC0TWM2OD1yLkCyOFg5KM7:TR?= MXfTRW5ITVJ?
TE-12 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDFclRKSzVyPUCuNFI2PSEQvF2= NFvaR4tUSU6JRWK=
MZ7-mel NHW3dVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMEK2NFkh|ryP NFnZfZZUSU6JRWK=
MMAC-SF NXXyXIZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jZWGlEPTB;MD6wNlY{OyEQvF2= NYfrfZd4W0GQR1XS
A101D NWfINJR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\xUFNKSzVyPUCuNFI3PSEQvF2= NYr5RmVzW0GQR1XS
GR-ST NIO2XHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO1UJlEUUN3ME2wMlAzPjV3IN88US=> M4fHd3NCVkeHUh?=
MC116 NVL5WIN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHvW48{UUN3ME2wMlAzPjhizszN NHv3OXVUSU6JRWK=
Ramos-2G6-4C10 NV7CUYNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHoTWM2OD1yLkCyO|Uh|ryP M331SnNCVkeHUh?=
ATN-1 MlXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEK3PFkh|ryP M1HY[nNCVkeHUh?=
MFH-ino M4DWeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[zO5VKSzVyPUCuNFI5OTJizszN M2TVUnNCVkeHUh?=
DEL NEDSVIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLV[nZlUUN3ME2wMlAzQDF3IN88US=> M3y5dXNCVkeHUh?=
OCI-AML2 MmrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;nTWM2OD1yLkCyPFcyKM7:TR?= M2DZSnNCVkeHUh?=
LXF-289 MofIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHKc5l7UUN3ME2wMlAzQDd{IN88US=> NHfT[ZNUSU6JRWK=
IA-LM MnyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEK5NVch|ryP Ml\NV2FPT0WU
EoL-1-cell MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3ETWM2OD1yLkCyPVk3KM7:TR?= M4\QO3NCVkeHUh?=
OVCAR-4 NWHjU|J[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;3W4pMUUN3ME2wMlA{ODl2IN88US=> NVnje|A{W0GQR1XS
ES1 M17q[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMEOwPVch|ryP NV7mdHQ2W0GQR1XS
CESS NYjGSIZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEOwPVkh|ryP M4Xv[nNCVkeHUh?=
GAK MoHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjzU|VKSzVyPUCuNFMyQDZizszN M3rqfHNCVkeHUh?=
NTERA-S-cl-D1 MmnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXhbHA{UUN3ME2wMlA{OjJ4IN88US=> NHrnbGZUSU6JRWK=
TE-10 NWjiPWtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjOSmVKSzVyPUCuNFM{OTFizszN NXPufVdHW0GQR1XS
CCRF-CEM Mo\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Ty[mlEPTB;MD6wN|M4OSEQvF2= NF\aR|dUSU6JRWK=
NMC-G1 NHHse3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfiVW9WUUN3ME2wMlA{PDR6IN88US=> NIf3enVUSU6JRWK=
HOP-62 M1OzUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPiNXdrUUN3ME2wMlA{PTV4IN88US=> NGjZNnhUSU6JRWK=
SH-4 NVrTNYZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjQd4NKSzVyPUCuNFM2QDJizszN NGLYeW9USU6JRWK=
NCI-H1648 Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HJRmlEPTB;MD6wN|YzOiEQvF2= MXHTRW5ITVJ?
EB-3 M1TKTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fDW2lEPTB;MD6wN|Y1OyEQvF2= MnHqV2FPT0WU
BB65-RCC M1nRZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLoTWM2OD1yLkCzOlkyKM7:TR?= MXvTRW5ITVJ?
BE-13 M1vB[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGi4Z3FKSzVyPUCuNFM4PTlizszN MWjTRW5ITVJ?
CP67-MEL MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDzOGlKSzVyPUCuNFM4PTlizszN NHG5ZmNUSU6JRWK=
SW954 NXLCeWhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13jdGlEPTB;MD6wN|c6KM7:TR?= MUnTRW5ITVJ?
TE-5 MofVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnPdYZvUUN3ME2wMlA{QDV2IN88US=> NHrzRWlUSU6JRWK=
HCE-4 Ml\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml6yTWM2OD1yLkCzPFU2KM7:TR?= MUnTRW5ITVJ?
LC-1F MnP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT0OHpKSzVyPUCuNFM6QDlizszN M{\ZWXNCVkeHUh?=
TK10 MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW1[412UUN3ME2wMlA1ODF7IN88US=> M2\XNnNCVkeHUh?=
SJSA-1 NXzLNYVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XoZ2lEPTB;MD6wOFE5QCEQvF2= Ml7kV2FPT0WU
Daudi NFXZb5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvWc4RKSzVyPUCuNFQzOjVizszN M2fLenNCVkeHUh?=
SW982 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrDV5BKSzVyPUCuNFQzPDZizszN M4jFWnNCVkeHUh?=
SF126 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnBUYZJUUN3ME2wMlA1OzZzIN88US=> MWXTRW5ITVJ?
TE-15 M4q5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;qdZVKSzVyPUCuNFQ1OzVizszN MmSyV2FPT0WU
COLO-684 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTuTWM2OD1yLkC0OVYyKM7:TR?= NF3iOYdUSU6JRWK=
8-MG-BA NIXkSpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mom4TWM2OD1yLkC0OlI6KM7:TR?= NUfJbJMzW0GQR1XS
NB13 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLZTWM2OD1yLkC0O|c3KM7:TR?= MkDEV2FPT0WU
HCC1599 NWPDVG9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMES4O|kh|ryP M2Sy[XNCVkeHUh?=
SK-PN-DW NVvpTJZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jVfWlEPTB;MD6wOFk1QSEQvF2= MUnTRW5ITVJ?
ALL-PO MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojBTWM2OD1yLkC0PVU3KM7:TR?= MnPOV2FPT0WU
NB6 M175eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfUdZBKSzVyPUCuNFUzPzFizszN NGjD[W5USU6JRWK=
IST-SL2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfGTWM2OD1yLkC1N|YzKM7:TR?= NIf3RZhUSU6JRWK=
BB30-HNC NUXWNJlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DOcWlEPTB;MD6wOVc{KM7:TR?= NFPx[HdUSU6JRWK=
SW962 NXy0TlFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnTTXFXUUN3ME2wMlA2PzZ|IN88US=> M{jjUHNCVkeHUh?=
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HCC2157 NFTWO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PpcGlEPTB;MD6zN|k2PCEQvF2= M3W4U3NCVkeHUh?=
LS-1034 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwM{[zPFgh|ryP MnL6V2FPT0WU
BOKU NEjlVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorCTWM2OD1yLkO3NVk6KM7:TR?= MXnTRW5ITVJ?
GDM-1 NHnIWW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWSyXnV[UUN3ME2wMlM4OjN2IN88US=> MYnTRW5ITVJ?
TGW NWXKbZJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln6TWM2OD1yLkO3OFU{KM7:TR?= NFnRWpFUSU6JRWK=
SNU-C1 M{jKSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTkTWM2OD1yLkO4NlE2KM7:TR?= NHvUPXdUSU6JRWK=
LS-513 NVSxdZptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPkRXpZUUN3ME2wMlM6ODdzIN88US=> MV;TRW5ITVJ?
NOMO-1 NYnUW4F5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nubmlEPTB;MD6zPVk4OSEQvF2= MnzxV2FPT0WU
MS-1 NFu4R25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jSemlEPTB;MD60NFE4PyEQvF2= M1H6RXNCVkeHUh?=
EKVX NUjUU5dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwNES0OlEh|ryP MXfTRW5ITVJ?
SK-MEL-2 NIC4[mZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXWTWM2OD1yLkS2OEDPxE1? NXzmU3pJW0GQR1XS
HCC1187 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwNE[3Olgh|ryP MofqV2FPT0WU
HCC2218 NUjpNWxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;oXYRKSzVyPUCuOFczOjdizszN Mm\0V2FPT0WU
NCI-H187 NWj0XYZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwNEe4OEDPxE1? M376U3NCVkeHUh?=
DB M2H0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwNUCwOVUh|ryP NGnwNFNUSU6JRWK=
NCI-H69 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwNUCyOFch|ryP MmD3V2FPT0WU
NCI-H1694 NILCRo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwNUC2PVch|ryP MXHTRW5ITVJ?
CA46 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfqPWNKSzVyPUCuOVA6OTdizszN NITzN3VUSU6JRWK=
EHEB MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwNUGxPVMh|ryP M4nCfXNCVkeHUh?=
NCCIT NH\BdnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\rTWM2OD1yLkW0N|IyKM7:TR?= MWTTRW5ITVJ?
NCI-H720 NWm3PIdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3vTWM2OD1yLkW0PVYzKM7:TR?= NYP2RlJrW0GQR1XS
LU-134-A MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHXTWM2OD1yLkW1Nlk3KM7:TR?= M13N[XNCVkeHUh?=
MC-CAR M3K0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\hToFWUUN3ME2wMlU2PDNzIN88US=> Mne0V2FPT0WU
NEC8 Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDQPINCUUN3ME2wMlU3OTd{IN88US=> NEDV[|dUSU6JRWK=
NCI-H524 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;xOGFKSzVyPUCuOVg4PDhizszN MYDTRW5ITVJ?
NCI-H1963 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X4PWlEPTB;MD62NlU5KM7:TR?= Mn[wV2FPT0WU
SU-DHL-1 NHLhVZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwNkS1NlYh|ryP NH;QeWFUSU6JRWK=
NCI-H1522 NHjCVZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofZTWM2OD1yLk[0PFg{KM7:TR?= MXrTRW5ITVJ?
NCI-H1155 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\4RplPUUN3ME2wMlY2OzVizszN NFj3[nNUSU6JRWK=
D-263MG M1T1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVqzd445UUN3ME2wMlY3OTBzIN88US=> NY\sVYpiW0GQR1XS
TE-6 NHXicoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwNkixNFQh|ryP NYPRTXV7W0GQR1XS
NCI-H1417 MmLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LVd2lEPTB;MD62PVcyOSEQvF2= NYHBUnJ7W0GQR1XS
NCI-H510A NHnvR4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLSTWM2OD1yLke3NlM3KM7:TR?= MoHsV2FPT0WU
KARPAS-45 NIntS3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFO4V2hKSzVyPUCuO|gzOzVizszN NF63RoVUSU6JRWK=
IST-SL1 NVPSepdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwOEW4NlUh|ryP MX7TRW5ITVJ?
COLO-824 NYLnOlBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwOEe4N|Uh|ryP MULTRW5ITVJ?
NCI-H526 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwOUC5OVgh|ryP NWjGc2g1W0GQR1XS
NCI-H719 NVv4U2ZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoO5TWM2OD1yLkm2OlU4KM7:TR?= M3:1dnNCVkeHUh?=
SF539 Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\SemlEPTB;MD65PFM6PiEQvF2= MlHSV2FPT0WU
NKM-1 NX\B[4E1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHnTHFVUUN3ME2wMlk5PjZ|IN88US=> MnHjV2FPT0WU
A253 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LtbWlEPTB;MD65PFg5PSEQvF2= NVfqcIdMW0GQR1XS
TE-441-T NGHjU5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXQNnplUUN3ME2xMlA1OzVizszN MYXTRW5ITVJ?
COR-L88 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFwMUGzOVQh|ryP NETsZ4FUSU6JRWK=
CPC-N NXfmNmhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFz1fY5KSzVyPUGuNVU5QDhizszN MkDmV2FPT0WU
NCI-H2107 NYjqe5hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3r2U2lEPTB;MT6xO|I3OSEQvF2= NYDvfJF5W0GQR1XS
ECC4 M3L1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4S4SGlEPTB;MT6xPFY6OyEQvF2= MUfTRW5ITVJ?
NCI-H2141 NY\XfIlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfNTWM2OD1zLkG5Nlk6KM7:TR?= MofaV2FPT0WU
NCI-H1770 NXPUdphTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TvUWlEPTB;MT6zNlkzQCEQvF2= NGf6bpRUSU6JRWK=
NCI-SNU-1 M{\IbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGD1UJpKSzVyPUGuN|MxPCEQvF2= NF23RolUSU6JRWK=
LU-165 NYHMfm5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTFwNEW0Olch|ryP NVfvSmhLW0GQR1XS
Raji NFW4dlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XXZWlEPTB;MT60O|I2QSEQvF2= NYLTemFrW0GQR1XS
EW-24 Mnn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFOzZ|NKSzVyPUGuOVQ3OTlizszN Mnv1V2FPT0WU
KP-N-RT-BM-1 NH76NnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPkTWM2OD1zLkW2OVUyKM7:TR?= MlfKV2FPT0WU
SK-MEL-1 NV3n[lM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTFwNkS4O|ch|ryP NHzmbGtUSU6JRWK=
SCLC-21H M{i5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEX1XGpKSzVyPUGuOlY3PTFizszN NVzOXlRvW0GQR1XS
SIMA Mmn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjZc2R{UUN3ME2xMlY5OjN|IN88US=> NYq1[WhlW0GQR1XS
NCI-H1304 MnvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M170eGlEPTB;MT63NFc3PSEQvF2= NWH4SZJ6W0GQR1XS
REH MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVraVpduUUN3ME2xMlcyODd6IN88US=> MXzTRW5ITVJ?
KP-N-YS MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfwZpdKSzVyPUGuPVM2PTFizszN MlnNV2FPT0WU
DMS-153 M1Hlbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLpUFRqUUN3ME2xMlk4PTlizszN NHvZeVhUSU6JRWK=
NB10 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vJfmlEPTB;Mj6yNFg4QCEQvF2= NV34SpNEW0GQR1XS
NCI-H345 NEDjRVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPpbGtKSzVyPUKuOlE6ODVizszN MUHTRW5ITVJ?
SK-N-FI M2rkXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvaTWM2OD1{Lke1N|gyKM7:TR?= M{HZNnNCVkeHUh?=
NCI-H1092 NYfK[oZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\LT3lKSzVyPUKuPVU{QTRizszN NG\2V29USU6JRWK=
KM-H2 NHLJOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXCdHc2UUN3ME2zMlY2Ozl4IN88US=> NEXyNGlUSU6JRWK=
KG-1 M2HXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\pTWM2OD1|LkexOlg5KM7:TR?= Moq2V2FPT0WU
D-283MED MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Xk[mlEPTB;Mz63OVg4KM7:TR?= M2f6OXNCVkeHUh?=
LU-65 MkPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XKW2lEPTB;ND6xNVQ5PSEQvF2= NFnnR2lUSU6JRWK=
MSTO-211H NXfGV2FHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj2TWM2OD12LkG4PFk5KM7:TR?= MnjmV2FPT0WU
NCI-H2081 NEWyc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn3cGxKSzVyPUSuNlkyPzRizszN NFj5dI9USU6JRWK=
D-247MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f2ZWlEPTB;ND60N|E6OSEQvF2= MmrSV2FPT0WU
P31-FUJ NGjQTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTRwNEWwNVkh|ryP M3XSWHNCVkeHUh?=
DMS-79 NEfPNGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvnVVZTUUN3ME20Mlk{OTh|IN88US=> MonjV2FPT0WU
KASUMI-1 NF7hVIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;xfWpKSzVyPUSuPVc2ODlizszN NEPO[phUSU6JRWK=
JVM-3 MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETPb5JKSzVyPUWuNlUxOTRizszN NHqxfFVUSU6JRWK=
LAN-6 NV;DfHZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[5TWM2OD13LkWxO|M3KM7:TR?= M3jOdHNCVkeHUh?=
DJM-1 MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTVwNU[wNlkh|ryP NXPEUnRSW0GQR1XS
JVM-2 NXHHT5R2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M12wd2lEPTB;NT62O|A6OiEQvF2= NVPTXo1WW0GQR1XS
U-87-MG MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LaNWlEPTB;NT64PVk3PCEQvF2= Mmm3V2FPT0WU
SHP-77 M2rkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTVwOUS5Nlgh|ryP NFLHdYpUSU6JRWK=
RPMI-8866 MnnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;GcWlEPTB;Nj6yO|AyOyEQvF2= MU\TRW5ITVJ?
ES7 NULMR4NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{C3dWlEPTB;Nj6zPVkzPCEQvF2= MYjTRW5ITVJ?
WSU-NHL MmHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVz1XlF{UUN3ME22MlUyPjB7IN88US=> NIXYVoRUSU6JRWK=
CAS-1 NYnFOpp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP5TWM2OD15LkC5O|Q6KM7:TR?= MmnaV2FPT0WU
MHH-NB-11 NXPDVYxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRThwMkOxOVIh|ryP NYC3Zm9IW0GQR1XS
ES5 NUnqSGJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTlwNUKyPFYh|ryP NWfLVoE3W0GQR1XS
HDLM-2 NFOwVlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\GV2lEPTB;OT65OVkxOiEQvF2= Moq3V2FPT0WU
NCI-H2171 M1\P[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFyLkW5Nlch|ryP NEjDdotUSU6JRWK=
LNCaP-Clone-FGC NF;tbVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTFzLkO3NVgh|ryP M2PPb3NCVkeHUh?=
NCI-H1395 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTF{LkK2PVkh|ryP MmS4V2FPT0WU
NCI-H1436 MlLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf1XGZyUUN3ME2xN{4{OTl3IN88US=> M130T3NCVkeHUh?=
RCC10RGB NFvoPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXOSlhKSzVyPUGzMlMzOjFizszN MmTTV2FPT0WU
SW684 NWSyXJhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTF|Lkm3PVch|ryP NX36Xph5W0GQR1XS
NCI-H1650 NGC2dGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzGZVJlUUN3ME2xOU4xPDR5IN88US=> M4OwRXNCVkeHUh?=
EW-13 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF21dHRKSzVyPUG1MlIxOjFizszN NEHy[GFUSU6JRWK=
EC-GI-10 M{PFXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfrTWM2OD1zNT64OlQ1KM7:TR?= Mm\QV2FPT0WU
CHP-126 MlzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTF5LkG5NVgh|ryP NVvn[5VMW0GQR1XS
NCI-H226 NIjmdI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;QRo04UUN3ME2xPE4xPDB|IN88US=> MYHTRW5ITVJ?
NCI-H1838 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HWW2lEPTB;MkCuNVg1QCEQvF2= M2HWe3NCVkeHUh?=
EW-11 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;NTWM2OD1{ND6yO|E5KM7:TR?= NVTTTFJEW0GQR1XS
EB2 MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTNzLkWzNVgh|ryP MmXVV2FPT0WU
D-502MG M{LOfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjYcJZKSzVyPUSzMlkzOjlizszN M3HsNHNCVkeHUh?=
U-698-M M{T2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;pU2lEPTB;NEiuPFY4OSEQvF2= MmHDV2FPT0WU
ES3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC4VXM2UUN3ME20PU4{QDl|IN88US=> MlriV2FPT0WU

... Click to View More Cell Line Experimental Data

体内研究 Torin1在20 mg/kg剂量下,在U87MG异种移植模型中是有效的,并且在肿瘤和外周组织中对mTOR下游效应蛋白表现出良好的药效学抑制作用。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[1]
+ 展开

mTORC1和 mTORC2体外激酶试验:

为产生可溶性mTORC1,HEK-293T细胞系,稳定表达N端FLAG标记的Raptor,使用水泡性口炎病毒G-假型病毒MSCV逆转录酶病毒产生。对于mTORC2,产生相似的HeLa细胞,能够稳定表达N端FLAG-标记的Protor-1。两个复合物通过在50 mm HEPES,pH 7.4,10 mm 焦磷酸钠,10 mm β-甘油磷酸钠,100 mm NaCl,2 mm EDTA,0.3% CHAPS中裂解细胞纯化。细胞在4 °C下裂解30分钟,不溶解部分通过以13,000 rpm微量离心10分钟移除。上清液与FLAG-M2单克隆抗体-琼脂糖培育1小时,然后用裂解缓冲液洗涤3次,用包含终浓度0.5 M NaCl的裂解缓冲液洗涤1次。纯化的mTORC1用100 μg/mL 3×FLAG多肽在50 mm HEPES,pH 7.4,100 mm NaCl中洗脱。将洗出液等分收集,储存在-80 °C。纯化底物S6K1 和 Akt1。激酶试验在30 °C,由激酶缓冲液(25 mm HEPES,pH 7.4,50 mm KCl,10 mm MgCl2,500 μm ATP)和150 ng 灭活的S6K1或Akt1底物组成的20 μL终体积混合物中进行。反应通过加入80 μL样品缓冲液停止,并沸煮5分钟。随后,样品通过SDS-PAGE和免疫印迹法分析。
细胞实验:[1]
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  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4天
  • Method: 细胞活性通过CellTiter-Glo发光法细胞活性测定评估。在第0天,细胞以500细胞每孔接种到96孔板,并生长过夜。第1天,细胞用适当的化合物处理,随后在第3-5天分析。对于分析,板在室温下培育60分钟,将50 μL CellTiter-Glo试剂加入每孔中,板在定轨摇床上混合12分钟。发光在标准平板光度计上定量。
    (Only for Reference)
动物实验:[2]
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  • Animal Models: U87MG 异种移植物模型
  • Formulation: Torin1粉末首先以25 mg/mL在100% N-甲基-2-吡咯烷酮中溶解,随后以1:4 与无菌 50% PEG400稀释到5 mg/mL的终浓度
  • Dosages: 20 mg/kg
  • Administration: 腹腔注射给药,每天一次
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
20% NMP+50% PEG 400
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 607.62
化学式

C35H28F3N5O2

CAS号 1222998-36-8
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    How to re-constitute the inhibitor for i.p. administration?

  • 回答:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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mTOR Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID