96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Bioactive Compound Library

提供2659种具有生物活性化合物的集合

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 197699.00
2x100uL/well (10mM solution) RMB 303138.46
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selleck分子库在文献中的引用

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产品详情

产品描述及优势

    • 2659种具有生物活性的化合物的独特集合,可用于高通量筛选和高内涵筛选
    • 通过前期临床研究和临床实验,生物活性和安全性得到验证
    • 其中一些化合物已经得到FDA批准
    • 包括大部分Selleck 抑制剂,原料药,天然产物,和化疗药物等
    • 结构多样,药效显著,可渗透细胞
    • 具有充分详细的结构说明,IC50值,及客户反馈资料
    • NMR和HPLC技术保证产品高纯度

产品详细信息

配制: 2659种具有生物活性的化合物预溶在DMSO溶液中
96-孔板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性:
1年 -20°C 溶于DMSO
2年 -80°C 溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

化合物库组成成份

Chemical Library Composition

客户使用Selleck产品的实验数据 (10)

AS-605240 Review
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数据来源 Nat Biotechnol ,2011, 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck
方法 Immunofluorescence analysis
细胞系 K562 cells
浓度 5 µM
处理时间 6 h
结果 SAHA and other nonselective HDAC inhibitors increased steady-state acetylation of tubulin and histones manifested by the staining of acetylated microtubules and punctuate nuclear staining of acetylated histone.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nature 2015, 520(7547), 368-72. Vemurafenib (PLX4032, RG7204) purchased from Selleck
方法 Animal studies
细胞系 A375 tumours
浓度 10 mg/kg
处理时间 4, 5 days
结果 Although vemurafenib treatment decreased the volume of sensitive tumours (A375 alone)(b), Green fluorescent protein (GFP) staining confirmed increased numbers of resistant cells in regressing tumours, and EdU or BrdU staining confirmed their increased proliferation rate compared to the vehicletreated controls (c). Tumours comprising only resistant cells showed no growth difference when treated with vehicle or vemurafenib (d), indicating that the growth advantage of resistant cells in regressing tumours was not caused by direct effects of vemurafenib on cancer or stromal cells. In line with these findings, A375R cells co-implanted with other vemurafenib-sensitive melanoma cell lines (Colo800, LOX and UACC62) also showed an up toeightfold growthincreasecompared to vehicle-treated control groups (e). Local growth acceleration of resistant cells in the regressing subcutaneous tumours resulted in higher lung metastatic burden (f).
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nature 2015, 520(7547), 368-72. Vemurafenib (PLX4032, RG7204) purchased from Selleck
方法 Immunofluorescence staining
细胞系 A375/A375R tumours
浓度 0.1-1 uM
处理时间 5 days
结果 This analysis highlighted FRA1 (also known FOSL1), a member of the AP1 transcription factor complex and effector of the ERK pathway27, as one of the putative upstream regulators of the TIS .FRA1 was downregulated in all drug-sensitive cells, but not in resistan cells, treated with vemurafenib, crizotinib and erlotinib (c, d).
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nature 2015, 517(7534), 391-5. PD0325901 purchased from Selleck
方法 Western blot
细胞系 Metabolic
浓度 10 mg/kg
处理时间 5 days
结果 PD0325901 caused a decrease in PPARc phosphorylation at S112 and S273, confirming the established role of ERKs in regulating S112 and strongly suggesting a new role in regulating S273 (refs 22-24).
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nature 2014, 510(7504), 283-7. Trametinib (GSK1120212) purchased from Selleck
方法 HE staining, IHC
细胞系 Smyd3 mutant mice
浓度 1 mg/kg
处理时间 7 days
结果 Administration of Kras and Kras;Smyd3 mutant mice with a normal dose of Trametinib blocked tumorigenesis in both strains, though phosphorylation of ERK1/2 was still lower in mice depleted of SMYD3. Notably, a low dose Trametinib regimen, which only partially inhibited pERK1/2 levels and the formation of neoplastic lesions in Kras mutant mice, was sufficient to block tumorigenesis and ERK1/2 activation in Smyd3 knockouts.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nature 2011, 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck
方法 MTT cell viability assay
细胞系 T-ALL cell lines
浓度 0.01-100 uM
处理时间 72 h
结果 It examined responsiveness to dexamethasone and the class I/II HDAC inhibitor vorinostat in a panel of T-ALL cell lines with wild type or mutant CREBBP alleles. This demonstrated sensitivity to vorinostat at clinically useful concentrations (IC50 below 1礛) in the majority of cell lines tested.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nature 2011, 478(7369):349-55. Sunitinib Malate purchased from Selleck
方法 Western immunoblots
细胞系 Mouse pancreatic stem cells
浓度 12 uM
处理时间 2 days
结果 Increased Ezh2 expression and β-cell BrdU incorporation were eliminated by simultaneous treatment with the receptor tyrosine kinase inhibitors Sunitinib.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nature 2011, 478(7369):349-55. Sunitinib Malate purchased from Selleck
方法 Immunofluorescent staining
细胞系 Mouse pancreatic stem cells
浓度 12 uM
处理时间 2 days
结果 Compared to vehicle-exposed controls, juvenile islets exposed to PDGF-AA had a sixfold increase of β-cell BrdU incorporation, an effect eliminated by simultaneous exposure to Sunitinib or U0126.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nature 2010, 468, 973-977. Selumetinib (AZD6244) purchased from Selleck
方法 Survival Assay
细胞系 isogenic cell
浓度 0.01-10 μM
处理时间 72 h
结果 The growth of M249 R4 and Pt55 R was sensitive to MEK inhibition in the presence of PLX4032
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nature 2010, 468, 968-972. Selumetinib (AZD6244) purchased from Selleck
方法 Immunoblotting
细胞系 A375 cells
浓度 1 μM
处理时间
结果 Ectopic COT expression in A375 and SKMEL28 cells also conferred decreased sensitivity to the MEK inhibitors CI-1040 and AZD6244, suggesting that COT expression alone was sufficient to induce this phenotype. In the setting of ectopic COT expression, exposure to AZD6244 or CI-1040 in combination with PLX470 (1 μM each) reduced cell growth and pERK expression more effectively than did single-agent PLX4720, even at concentrations of 10 μM.

Selleck产品在文献中的引用 (32)

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