96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Epigenetics Compound Library

提供182种具有生物活性的小分子调节剂的独特集合

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 40176.56
2x100uL/well (10mM solution) RMB 70481.73
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产品详情

产品描述及优势

    • 182种具有生物活性的小分子调节剂(抑制剂和激活剂)的独特集合,用于表观遗传学研究和相关实验。包含多种结构和机制不同的化合物
    • 一项研究化学基因组学,药物基因组学的表观靶向识别,和其他生物应用的有力工具
    • 表观遗传化合物库含有表观遗传酶的抑制剂,包括组蛋白去乙酰化酶(HDACs), SIRTs, 赖氨酸去甲基化酶, 组蛋白乙酰转移酶(HATs), DNA 甲基转移酶(Dnmts)和 SIRTs 激活剂
    • 结构多样,药效显著,可渗透细胞
    • 具有充分详细的结构说明,IC50值,及客户反馈资料
    • NMR和HPLC技术保证产品高纯度

产品详细信息

配制: 182种小分子调节剂(抑制剂和激活剂)预溶在DMSO溶液中
96-孔板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性:
1年 -20°C 溶于DMSO
2年 -80°C 溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

化合物库组成成份

Chemical Library Composition

客户使用Selleck产品的实验数据 (10)

AS-605240 Review
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数据来源 Nat Biotechnol ,2011, 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck
方法 Immunofluorescence analysis
细胞系 K562 cells
浓度 5 µM
处理时间 6 h
结果 SAHA and other nonselective HDAC inhibitors increased steady-state acetylation of tubulin and histones manifested by the staining of acetylated microtubules and punctuate nuclear staining of acetylated histone.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nature 2014, 508(7494), 118-22. Barasertib (AZD1152-HQPA) purchased from Selleck
方法 Long-term cell proliferation assays
细胞系 A375-SOX10KD cells
浓度 0.5 uM
处理时间 4 weeks
结果 Compared with controls, treatment of A375-SOX10KD cells with a combination of both vemurafenib and GDC0941 lead to proliferation arrest.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nature 2011, 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck
方法 MTT cell viability assay
细胞系 T-ALL cell lines
浓度 0.01-100 uM
处理时间 72 h
结果 It examined responsiveness to dexamethasone and the class I/II HDAC inhibitor vorinostat in a panel of T-ALL cell lines with wild type or mutant CREBBP alleles. This demonstrated sensitivity to vorinostat at clinically useful concentrations (IC50 below 1礛) in the majority of cell lines tested.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Cell 2010, 142, 444–455. VX-680 (Tozasertib, MK-0457) purchased from Selleck
方法 Immunofluorescence Microscopy
细胞系 HeLa cells
浓度
处理时间
结果 Inhibition of Aurora kinases with VX-680 sharply reduced kinetochore-localized pT422 signal (Figure G). When normalized to the total level of CENP-E at the kinetochore (which is also reduced in VX-680 treated cells (Ditchfield et al. 2003)), a > 90% reduction in T422 phosphorylation was seen following VX-680 treatment ( Figure H).
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nat Methods 2013, 10(10), 981-4. Iniparib (BSI-201) purchased from Selleck
方法 Immunoblot analysis
细胞系 HCT116
浓度 50 uM
处理时间 40 min
结果 Immunoblot analysis of PARylation after treatment with AIniparib.The asterisk indicates a nonspecific band.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Cell Stem Cell 2012, 11, 179-94. Alisertib (MLN8237) purchased from Selleck
方法 qPCR
细胞系 CCE cells
浓度 1 uM
处理时间 48 h
结果 Treatment with the Aurka-specific chemical inhibitor MLN8237 suppressed pluripotency TF expression and decreased fluorescence in the NG4 Nanog-GFP reporter line.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Cancer Discov 2012, 2(7), 591-7. Tofacitinib (CP-690550,Tasocitinib) purchased from Selleck
方法 Western blot
细胞系 NK-S1, KHYG-1 cells
浓度 0-2 uM
处理时间 48 h
结果 To further confirm the involvement of JAK/STAT signaling in the survival of NKTCLs, we next evaluated the effect of a pan-JAK inhibitor, CP-690550, in NK-S1, KHYG-1, and K562 cells. As expected, both the NK-S1 and KHYG-1 cells showed a reduction of phosphorylated STAT5.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Clin Invest 2014, 10.1172/JCI69094. Momelotinib (CYT387) purchased from Selleck
方法 Western blot
细胞系 IL-6- supported INA-6 cells
浓度 50 nM
处理时间 1 h
结果 To further establish that constitutive GP130 activation represents a model of IL-6–activated MM, it infected the human IL-6–dependent MM line INA-6. Treatment with JAK inhibitors (CYT387 and ruxolitinib) blocked STAT3 phosphorylation and caused cell cycle arrest.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 J Exp Med 2014, 10.1084/jem.20141123. Barasertib (AZD1152-HQPA) purchased from Selleck
方法 Giemsa staining
细胞系 Primary MKPs
浓度
处理时间
结果 Notably, Aurora B inhibitor (AZD-1152) treatment caused primary MKPs maturation and normal DNA ploidy.
Axitinib and PF2341066(Crizotinib) Reviews
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数据来源 Nat Commun 2014, 5, 3479. Tubastatin A HCl purchased from Selleck
方法 Immunoblotting
细胞系 RAW264.7
浓度 10 uM
处理时间 12 h
结果 Most importantly, the augmented p38 phosphorylation caused by TBSA was abrogated by MEC17 knockdown (Lanes 19-24).

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