96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Pfizer Licensed Compound Library

提供Pfizer辉瑞授权的94种药物化合物的独特集合

规格 价格  
预溶于DMSO
100uL/well (10mM solution) RMB 20163.00
2x100uL/well (10mM solution) RMB 32077.50
联系我们 |
全国免费电话: 400-668-6834 Email: info@selleck.cn

定制分子库

为了满足您的特殊需求,您可以从我们产品中选择想要的分子,重量,形态(干粉或溶液),排列顺序等。

selleck分子库在文献中的引用

Recommended Libraries

  • L1100

    A unique collection of 1695 inhibitors for high throughput screening (HTS) and high content screening (HCS).

  • L1200

    A unique collection of 430 kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).

  • L1300

    1443 FDA-approved drugs

HTS Facility Partners

Customer Reviews

  •  
     
     
     
     
  •  
     
     
     
     
  •  
     
     

产品详情

产品描述及优势

    • 所有具有生物活性的化合物都经Pfizer辉瑞公司授权许可,且已经在 销售或通过临床实践证明
    • 具有广泛的潜在用途:从抗癌化合物(Bosutinib)到甘氨酰抗生素(Tigecycline),用于解决日益普遍的抗生素耐药性。
    • 所购买的药物作为一个多样化的库,满足您的药物发现需求
    • 可靠性保障:所有化合物都经Pfizer公司开发,验证,和生产
    • 所有化合物都使用核磁共振和高效液相色谱法进行验证
    • 具有详细的临床前期研究数据和药品安全信息

产品详细信息

配制: 94种药物化合物的独特集合,预溶在DMSO溶液中
96-孔板: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
稳定性:
1年 -20°C 溶于DMSO
2年 -80°C 溶于DMSO
发货: 蓝冰物流
包装: 惰性气体

化合物库组成成份

Chemical Library Composition

客户使用Selleck产品的实验数据 (10)

AS-605240 Review
点击放大
评级
数据来源 Nature,2015, 517(7534), 391-5. PD0325901 purchased from Selleck
方法 Western blot
细胞系 Metabolic
浓度 10 mg/kg
处理时间 5 days
结果 PD0325901 caused a decrease in PPARc phosphorylation at S112 and S273, confirming the established role of ERKs in regulating S112 and strongly suggesting a new role in regulating S273 (refs 22-24).
Axitinib and PF2341066(Crizotinib) Reviews
点击放大
评级
数据来源 Nature 2011, 478(7369):349-55. Sunitinib Malate purchased from Selleck
方法 Western immunoblots
细胞系 Mouse pancreatic stem cells
浓度 12 uM
处理时间 2 days
结果 Increased Ezh2 expression and β-cell BrdU incorporation were eliminated by simultaneous treatment with the receptor tyrosine kinase inhibitors Sunitinib.
Axitinib and PF2341066(Crizotinib) Reviews
点击放大
评级
数据来源 Nature 2011, 478(7369):349-55. Sunitinib Malate purchased from Selleck
方法 Immunofluorescent staining
细胞系 Mouse pancreatic stem cells
浓度 12 uM
处理时间 2 days
结果 Compared to vehicle-exposed controls, juvenile islets exposed to PDGF-AA had a sixfold increase of β-cell BrdU incorporation, an effect eliminated by simultaneous exposure to Sunitinib or U0126.
Axitinib and PF2341066(Crizotinib) Reviews
点击放大
评级
数据来源 Science 2011, 331(6019), 912-6. PD173074 purchased from Selleck
方法 Immunohistochemistry
细胞系 uterine horn
浓度
处理时间
结果 The epithelia of vehicle-treated horn showed prominent expression of p-FRS2 and p-ERK1/2 (Fig. A, a and c). However, the levels of both p-FRS2 and p-ERK1/2 were reduced in the epithelia of PD173074-treated horn on day 4 of pregnancy (Fig. A, b and d). We also observed a marked decline in the proliferative activity of Hand2-null uterine epithelia, as indicated by decreased Ki-67 staining (Fig. A, e and f). Administration of either PD173074 (Fig. C, a to d) or PD184352 (Fig. C, e to h) to Hand2-null uterine horns blocked the phosphorylation of epithelial ER a at Ser118 and the expression of Muc-1.
Axitinib and PF2341066(Crizotinib) Reviews
点击放大
评级
数据来源 Nat Genet 2014, 46(4), 364-70. Rapamycin (Sirolimus) purchased from Selleck
方法 Western blot
细胞系 Persister cells
浓度 10 nM
处理时间 3 days
结果 While added with a specific mTOR inhibitor, rapamycin(Rapa), it inhibitied endogenous mTOR activity, showed that markedly reduced MYC protein levels in persister cells but not in naive T-ALL cells.
Axitinib and PF2341066(Crizotinib) Reviews
点击放大
评级
数据来源 2012, Dr. Yong-Weon Yi from Georgetown University Medical Center. CP-724714 purchased from Selleck
方法 MTT assays
细胞系 UWB1.289 cells
浓度 0-10 μM
处理时间 72 h
结果 CP-724714 inhibited the survival of UWB1.289 cells in a dose-dependent manner.
Axitinib and PF2341066(Crizotinib) Reviews
点击放大
评级
数据来源 Nat Med 2011, 17, 1116-1120. Crizotinib (PF-02341066) purchased from Selleck
方法 Western blot
细胞系 RCT-E565 transplanted tumors
浓度 25 mg/kg/d, 50 mg/kg/d
处理时间 0-21 d
结果 We then treated mice bearing RCT-E565 tumor transplants with PF02341066, a c-Met inhibitor currently in clinical development. PF02341066 abrogated both p-Akt and p-S6RP signals as well as tumor growth.
Axitinib and PF2341066(Crizotinib) Reviews
点击放大
评级
数据来源 Cancer Cell 2011, 19(6), 792-804. Rapamycin (Sirolimus) purchased from Selleck
方法 Cell viability Analysis
细胞系 Ar+murine (CaP8) and human (LNCaP) prostate cancer cells, Pb-Cre+;PtenL/L mice, Pb-Cre+;PtenL/L;ArL/Y mice
浓度 1 nM, 4 mg/kg
处理时间 0-4 weeks
结果 These data suggest that CaPs with AR loss have greater reliance upon the PI3K/AKT/mTOR-signaling pathways and that combined AR/androgen blockage in conjunction with PI3K/AKT/mTOR inhibition (by Rapamycin) is more effective for CaPs initiated by PTEN loss or PI3K/AKT activation.
Axitinib and PF2341066(Crizotinib) Reviews
点击放大
评级
数据来源 Cancer Cell 2011, 19, 679–690. Crizotinib (PF-02341066) purchased from Selleck
方法 Cell Growth Inhibition Assay
细胞系 Ba/F3 cells
浓度
处理时间 48 h
结果 The sensitivities of L1196M-driven Ba/F3 cell clones to PF-02341066 were lower, closely resembling that of the Ba/F3 parental cells. The therapeutic indexes of CH5424802 and PF-02341066, the IC50 ratio of EML4-ALK L1196M-driven cell clones to the parental cells, were 7- to 12-fold and 1- to 2-fold.
Axitinib and PF2341066(Crizotinib) Reviews
点击放大
评级
数据来源 Cancer Discov 2013, 3(6), 636-47. PD173074 purchased from Selleck
方法 Western blot
细胞系 SW780 cells
浓度 10, 40 mg/kg
处理时间
结果 Similar results for FGFR fusion-positive lines were obtained in vivo. SW780 xenografts exhibited decreased tumor growth with increasing doses of PD173074.

Selleck产品在文献中的引用 (32)

查看其他分子库

联系
我们