MitoQ (Mitoquinone) mesylate

目录号：S8978 批次号：S897801

化学数据

	别名	MitoQ10 mesylate, Mitoubiquinone mesylate	储存条件 (自收到货起)	2年 -20°C 液体
	化学式	C₃₈H₄₇O₇PS
	分子量	678.81	CAS号	845959-50-4
Solubility (25°C)*	体外	DMSO	50 mg/mL (73.65 mM)
		Water	10 mg/mL (14.73 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

MitoQ (Mitoquinone) mesylate是一种基于TPP的线粒体mitochondria靶向抗氧化剂，可阻断H₂O₂诱导的细胞内 ROS 反应并防止氧化损伤。该产品呈胶状。

靶点

mitochondria ^[1]

ROS ^[1]

参考文献

[1] Wei Huang, et al. Mediators Inflamm. 2015;2015:901780.

MitoQ (Mitoquinone) mesylate在文献中得到引用

Local production of reactive oxygen species drives vincristine-induced axon degeneration [ Cell Death Dis, 2023, 14(12):807]	PubMed: 38065950
O-GlcNAcylation Is Required for the Survival of Cerebellar Purkinje Cells by Inhibiting ROS Generation [ Antioxidants (Basel), 2023, 12(4)806]	PubMed: 37107182
Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis [ iScience, 2023, 26(9):107647]	PubMed: 37694150
MitoQ Protects Ovarian Organoids against Oxidative Stress during Oogenesis and Folliculogenesis In Vitro [ Int J Mol Sci, 2023, 24(2)924]	PubMed: 36674435
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling [ Immunity, 2022, S1074-7613(22)00280-1]	PubMed: 35835107
Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis [ Immunity, 2022, 55(7):1185-1199.e8]	PubMed: 35738281
HDAC class I inhibitor domatinostat sensitizes pancreatic cancer to chemotherapy by targeting cancer stem cell compartment via FOXM1 modulation [ J Exp Clin Cancer Res, 2022, 41(1):83]	PubMed: 35241126
Benchmarking AlphaFold-enabled molecular docking predictions for antibiotic discovery [ Mol Syst Biol, 2022, 18(9):e11081]	PubMed: 36065847
PARP-inhibition reprograms macrophages toward an anti-tumor phenotype [ Cell Rep, 2022, 41-2:111462]	PubMed: 36223740
Loss of legumain induces premature senescence and mediates aging-related renal fibrosis [ Aging Cell, 2022, 21(3):e13574]	PubMed: 35195326

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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