Nedisertib (M3814)

目录号：S8586 批次号：S858602

化学数据

	别名	Peposertib, MSC2490484A	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂₄H₂₁ClFN₅O₃
	分子量	481.91	CAS号	1637542-33-6
Solubility (25°C)*	体外	DMSO	48 mg/mL (99.6 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Nedisertib (M3814, Peposertib, MSC2490484A) 是一种口服可利用的、高效且选择性的 DNA activated protein kinase (DNA-PK) 的抑制剂，其IC50值小于3 nM。

靶点

DNA-PK ^[1]
(Cell-free assay)

3 nM

参考文献

Nedisertib (M3814)在文献中得到引用

HiHo-AID2: boosting homozygous knock-in efficiency enables robust generation of human auxin-inducible degron cells [ Genome Biol, 2024, 25(1):58]	PubMed: 38409044
Identification of the main barriers to Ku accumulation in chromatin [ bioRxiv, 2024, 2024.01.03.574002]	PubMed: 38260538
Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation [ bioRxiv, 2024, 2024.03.08.584115]	PubMed: 38559033
Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing [ Nat Commun, 2023, 14(1):4761]	PubMed: 37580318
Efficient correction of ABCA4 variants by CRISPR-Cas9 in hiPSCs derived from Stargardt disease patients [ Mol Ther Nucleic Acids, 2023, 32:64-79]	PubMed: 36969552
Fanconi anemia-associated chromosomal radial formation is dependent on POLθ-mediated alternative end joining [ Cell Rep, 2023, 42(5):112428]	PubMed: 37086407
Perturbations in 3D genome organization can promote acquired drug resistance [ Cell Rep, 2023, 42(10):113124]	PubMed: 37733591
Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy [ NPJ Precis Oncol, 2023, 7(1):61]	PubMed: 37380890
Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy [ NPJ Precis Oncol, 2023, 7(1):61]	PubMed: 37380890
High-Efficiency CRISPR/Cas9-Mediated Correction of a Homozygous Mutation in Achromatopsia-Patient-Derived iPSCs [ Int J Mol Sci, 2023, 24(4)3655]	PubMed: 36835061

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

退换货政策

Selleck提供宽松的退换货承诺，努力为您营造最优的购物体验。每个订单Selleck只提供一次退换货服务，为了确保您的权益，请您仔细阅读以下内容：

1. 请在返还样品之前事先与我们取得联系，以确保产品是直接向我们或者当地代理商购买的；

2. 自收到货物起七天内，如因运输过程有问题或其他任何问题，您可以提出退换货要求；自收到货物起365天内，如因产品质量有问题，您可以提出退换货要求。

3. 请使用我们的快递账号进行退换货，您无需为此承担任何费用。

4. 如您已收到由Selleck开具的发票，则办理退货或订单金额发生变更的换货时，请将发票随商品一同返还给Selleck。请您妥善保管发票，如发票丢失，将无法办理退换货手续。