Y-27632

目录号：S6390 批次号：S639001

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₁₄H₂₁N₃O
	分子量	247.34	CAS号	146986-50-7
Solubility (25°C)*	体外	DMSO	49 mg/mL (198.1 mM)
		Ethanol	49 mg/mL (198.1 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Y-27632是一种选择性ROCK1和ROCK2抑制剂，无细胞试验中Ki分别为140 nM和300nM，比对其他激酶包括PKC，cAMP依赖性蛋白激酶，MLCK和PAK的作用强200多倍。

靶点

ROCK1 ^[1] (Cell-free assay)	ROCK2 ^[1] (Cell-free assay)
140 nM(Ki)	300 nM(Ki)

参考文献

Y-27632在文献中得到引用

Nongenetic Optical Modulation of Pluripotent Stem Cells Derived Cardiomyocytes Function in the Red Spectral Range [ Adv Sci (Weinh), 2024, 11(3):e2304303]	PubMed: 37948328
Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancer [ Cell Rep Med, 2024, 5(2):101396]	PubMed: 38290515
Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition [ J Exp Clin Cancer Res, 2024, 43(1):88]	PubMed: 38515178
Biosafe cerium oxide nanozymes protect human pluripotent stem cells and cardiomyocytes from oxidative stress [ J Nanobiotechnology, 2024, 22(1):132]	PubMed: 38532378
Cell mechanics regulate the migration and invasion of hepatocellular carcinoma cells via JNK signaling [ Acta Biomater, 2024, S1742-7061(24)00036-9]	PubMed: 38272199
Culture and expansion of murine proximal airway basal stem cells [ Stem Cell Res Ther, 2024, 15(1):26]	PubMed: 38287366
Kupffer cells abrogate homing and repopulation of allogeneic hepatic progenitors in injured liver site [ Stem Cell Res Ther, 2024, 15(1):48]	PubMed: 38378583
Btbd8 deficiency reduces susceptibility to colitis by enhancing intestinal barrier function and suppressing inflammation [ Front Immunol, 2024, 15:1382661]	PubMed: 38558797
The Analysis of Embryoid Body Formation and Its Role in Retinal Organoid Development [ Int J Mol Sci, 2024, 25(3):1444.]	PubMed: 38338722
Traces of Canine Inflammatory Bowel Disease Reflected by Intestinal Organoids [ Int J Mol Sci, 2024, 25(1)576]	PubMed: 38203746

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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