CRBN 选择性抑制剂 | 化学产品 | 调节剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S8760 Iberdomide (CC220)

Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities.

Selective cereblon, IC50: 60 nM
S6794 Thalidomide-O-COOH (Cereblon ligand 3)

Thalidomide-O-COOH (Cereblon ligand 3, E3 ligase Ligand 3), a Thalidomide-based Cereblon (CRBN) ligand, is used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera).

Selective
S1029 Lenalidomide (CC-5013)

Lenalidomide (CC-5013)是一种TNF-α分泌抑制剂,在PBMCs中IC50为13 nM。

Selective
S2881 Homo-PROTAC cereblon degrader 1

Homo-PROTAC cereblon degrader 1 (compound 15a) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3.

Selective
S8300 CC-885

CC-885 is a novel cereblon (CRBN) modulator. CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation.

Selective
S8975 Mezigdomide (CC-92480)

CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with high affinity to cereblon, resulting in potent antimyeloma activity.

Selective
S1567 Pomalidomide (CC-4047)

Pomalidomide抑制LPS诱导的TNF-α释放,在PBMCs中IC50为13 nM。

Selective
S7892 Avadomide (CC-122)

CC-122,一种新型的多效性修饰剂化合物,在弥漫性大B细胞淋巴瘤(DLBCL)中具有抗肿瘤、免疫调节活性。其分子靶标为cereblon (CRBN),CRBN是E3泛素化连接酶复合体CRL4CRBN的底物受体。

Selective
S8979 THAL-SNS-032

THAL-SNS-032 is a selective CDK9 degrader PROTAC which consists of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).

Selective
S9832 CC-90009

CC-90009 is a novel cereblon (CRBN) E3 ligase modulator and specifically targets GSPT1 (G1 to S phase transition 1) for proteasomal degradation.

Selective