• PKCα
  • PKCβ
  • PKCγ
  • PKCδ
  • PKCε
  • PKCζ
  • PKCη
  • PKCθ
  • PKCι

PKCθ 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S0069 VTX-27 VTX-27 (Compound 27) is a potent and selective inhibitor of protein kinase C θ (PKC θ) with Ki of 0.08 nM and 16 nM for PKC θ and PKC δ, respectively. Selective PKCθ, Ki: 0.08 nM
S6577 PKC-theta inhibitor PKC-theta inhibitor (compound 20) inhibits PKC-θ with an IC50 of 18 nM. Selective PKCθ, IC50: 18 nM
S2791 Sotrastaurin (AEB071) Sotrastaurin (AEB071) is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM in a cell-free assay; inactive to PKCζ. Phase 2. Pan PKCθ, Ki: 0.22 nM
S1113 GSK690693 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1. Pan PKCθ, IC50: 2 nM
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