4-PBA (4-Phenylbutyric acid)

目录号：S3592 批次号：S359202

化学数据

	别名	Benzenebutyric acid	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₁₀H₁₂O₂
	分子量	164.20	CAS号	1821-12-1
Solubility (25°C)*	体外	DMSO	500 mg/mL (3045.06 mM)
		Ethanol	33 mg/mL (200.97 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

4-PBA (4-Phenylbutyric acid)是 histone deacetylase (HDAC) 抑制剂，是抗 HCV 的肝铁调素的主要表观遗传诱导剂。4-Phenylbutyric acid 通过调节急性肺损伤模型中的内质网压力 endoplasmic-reticulum (ER) stress 和自噬来抑制LPS诱导的炎症。

靶点

HDAC ^[1]

参考文献

[4] Park HJ, et al. Biochem Pharmacol. 2018 May;151:9-17.

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4-PBA (4-Phenylbutyric acid)在文献中得到引用

A novel CSN5/CRT O-GlcNAc/ER stress regulatory axis in platinum resistance of epithelial ovarian cancer [ Int J Biol Sci, 2024, 20(4):1279-1296]	PubMed: 38385070
Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke [ J Transl Med, 2024, 22(1):248]	PubMed: 38454480
IRE1α arm of unfolded protein response in muscle-specific TGF-β signaling-mediated regulation of muscle cell immunological properties [ Cell Mol Biol Lett, 2023, 28(1):15]	PubMed: 36849929
Porcine reproductive and respiratory syndrome virus infection triggers autophagy via ER stress-induced calcium signaling to facilitate virus replication [ PLoS Pathog, 2023, 19(3):e1011295]	PubMed: 36972295
Routes of Albumin Overload Toxicity in Renal Tubular Epithelial Cells [ Int J Mol Sci, 2023, 24(11)9640]	PubMed: 37298591
Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression [ Int J Mol Sci, 2023, 10.3390/ijms241813825]	PubMed: 37762128
Endoplasmic reticulum stress mediates environmental particle-induced inflammatory response in bronchial epithelium [ J Immunotoxicol, 2023, 10.1080/1547691X.2023.2229428]	PubMed: 37417782
Effects of endoplasmic reticulum stress on erectile function in rats with cavernous nerve injury [ Sex Med, 2023, 11(4):qfad050]	PubMed: 37674767
ASK1-ER stress pathway-mediated fibrotic-EV release contributes to the interaction of alveolar epithelial cells and lung fibroblasts to promote mechanical ventilation-induced pulmonary fibrosis [ Exp Mol Med, 2022, 1-13.]	PubMed: 36473935
A heterozygous p.S143P mutation in LMNA associates with proteasome dysfunction and enhanced autophagy-mediated degradation of mutant lamins A and C [ Front Cell Dev Biol, 2022, 10:932983]	PubMed: 36111332

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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