2015年1月至今,引用Selleck产品的顶级学术期刊文献已达 160 篇!

新产品

目录号 产品名 Target Pathway 产品描述
S8792 UAMC-3203 Ferroptosis Metabolism UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.
S8684 Selective JAK3 inhibitor 1 JAK JAK/STAT Selective JAK3 inhibitor 1 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM, 740 nM for JAK3, JAK1 and JAK2 respectively. It is also selective over the other kinases possessing a cysteine in the same region as JAK3, such as BMX, EGFR, ITK, and BTK.
S8840 SEL120(SEL120-34,SEL120-34A) CDK Cell Cycle SEL120(SEL120-34,SEL120-34A) is a novel inhibitor of Cyclin-dependent kinase 8 (CDK8) with IC50 values of 4.4 nM and 10.4 nM for CDK8/Cyclin C and CDK19/CyclinC respectively.
S8823 ABX-1431 Lipase Metabolism ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.
S8795 FDL169 CFTR Transmembrane Transporters FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.
S8341 TAK-243 (MLN7243) E1 Activating Ubiquitin TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II.
S8821 GSK3179106 c-RET Apoptosis GSK3179106 is a potent, selective, and gut-restricted pyridone hinge binder small molecule RET kinase inhibitor with a RET IC50 of 0.3 nM and is efficacious in vivo.
S8793 ULK-101 Autophagy Autophagy ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.