首页抗体偶联药物相关(ADC)

抗体偶联药物相关(ADC)

目录号 产品名 产品描述
S0328 MMAF MMAF (Monomethylauristatin F) 是一种合成抗肿瘤药，是 tubulin 聚合的有效抑制剂。MMAF (Monomethylauristatin F) 可被用作抗体偶联药物(ADCs, 例如 vorsetuzumab mafodotin、ABT-414和SGN-CD19A)中的细胞毒性成分。
S0346 NAcM-OPT NAcM-OPT 是一种特异性的、可逆的和口服生物利用的 cullin neddylation 1 (DCN1) 抑制剂，并靶向 N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) 与DCN1的相互作用，其IC50值为79 nM。
S0556 ACT-389949 ACT-389949 is a potent, selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX) with EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for inflammatory disorders.
S0557 PNU-159682 PNU-159682 is a highly potent metabolite of the anthracycline nemorubicin (DNA topoisomerase II inhibitor) with outstanding cytotoxicity. PNU-159682 is a potent ADCs cytotoxin.
S0559 Maytansinol Maytansinol (Ansamitocin P-0) is an inhibitor of microtubule assembly that induces microtubule disassembly in vitro.
S0561 Auristatin E Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. Auristatin E is an MMAE analog and cytotoxin in Antibody-drug conjugates (ADCs). Auristatin E inhibits cell division by blocking the polymerisation of tubulin.
S0562 Ansamitocin P 3' Ansamitocin P 3' (Antibiotic C 15003P3', Maytansinol butyrate) is an antibody drug conjugate (ADC) cytotoxin, exhibiting antitumour activity.
S0563New 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel)是紫杉醇的衍生物，也是天然存在的木糖苷，从Taxus chinensis中分离出来，它可以引起PC-3细胞明显的有丝分裂停滞，并上调促凋亡蛋白Bax和Bad的表达，以及下调抗凋亡蛋白Bcl-2和Bcl-XL的表达，从而导致线粒体膜通透性的紊乱和caspase-9的激活。
S0564 SPDP SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with cysteine sulfhydryls. SPDP is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).
S0565 DBCO-NHS ester DBCO-NHS ester is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0566New Sulfo-SMCC sodium Sulfo-SMCC sodium是一种异双功能、不可裂解的ADC 交联剂，它由 N-羟基琥珀酰亚胺(N-hydroxysuccinimide, NHS)酯和马来酰亚胺基团与伯胺和巯基反应。
S0567 Amino-PEG4-alcohol Amino-PEG4-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. Amino-PEG4-alcohol is a non-cleavable 4-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
S0701 Conantokin G Conantokin G (Con-G, CGX-1007, Conotoxin GV, Sleeper peptide) is a selective and competitive antagonist of GluN2B receptor.
S0702New α-Conotoxin GI α-ConotoxinGI最初是从鸡心螺的猎鱼毒液中分离出来的13残基肽，作为肌肉型烟碱型乙酰胆碱受体（Nicotinic acetylcholine receptors, nAChRs）的竞争性拮抗剂，相对α/γ来说，对α/δ受体亚单位结合具有极好的选择性。
S0704 Delsoline Delsoline, a major alkaloid of Delphinium anthriscifolium Hance, has both a curare-like effect and a ganglion-blocking effect. Delsoline is used to relieve muscle tension or hyperkinesia. Delphinium anthriscifolium Hance has effects of dispelling wind and dampness, activating collaterals, and relieving pains and is used to treat rheumatism, hemiplegia, indigestion, and cough.
S1150 Paclitaxel (NSC 125973) Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane)是一种microtubule聚合物稳定剂，在人内皮细胞中IC50为0.1 pM。
S1208 Doxorubicin (Adriamycin) HCl Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl是一种抗生素类试剂，可抑制DNA topoisomerase II，并在肿瘤细胞中诱导DNA损伤、线粒体自噬和凋亡。Doxorubicin 可降低 AMPK的基础磷酸化。Doxorubicin 可应用于HIV感染病人的联合治疗，但是在免疫治疗中有将HBV重活化的风险。
S1210 Methotrexate (CL-14377) Methotrexate (CL14377, MTX, NCI-C04671, Amethopterin, WR19039, abitrexate),一种叶酸类似物，是细菌、癌细胞和正常细胞中dihydrofolate reductase(DHFR)的非选择性抑制剂，与DHFR、NADPH形成无活性的三元复合物。Methotrexate (MTX)可诱导凋亡。
S1282 Artemisinin Artemisinin (Qinghaosu, Artemisinine)青蒿素用于治疗耐多药的恶性疟疾菌株。
S1288 Camptothecin (NSC-100880) Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) 是一种特异性的DNA拓扑异构酶I (Topo I)抑制剂，IC50为0.68 μM。Camptothecin 在癌细胞中可通过microRNA-125b介导的线粒体信号通路来诱导凋亡。Phase 2。
S1339 Galanthamine HBr Galanthamine HBr是一种AChE抑制剂，IC50为0.35 μM，比作用于丁酰胆碱酯酶选择性高50倍。
S1421 Staurosporine (AM-2282) Staurosporine (AM-2282, Antibiotic AM-2282, STS)是一种有效的PKC抑制剂，在无细胞试验中作用于PKCα，PKCγ 和PKCη，IC50分别为2 nM，5 nM 和 4 nM，对PKCδ(20 nM)和PKCε(73 nM作用较弱，对PKCζ (1086 nM)的活性很低。同时 对其他的激酶PKA, PKG, S6K, CaMKII, 等也显示抑制活性。Phase 3。
S1640 Albendazole (SKF-62979) Albendazole (SKF-62979) 是一种苯并咪唑类化合物，用于治疗各种蠕虫感染。
S2130 Atropine sulfate monohydrate Atropine sulfate monohydrate是一种竞争性毒蕈碱型乙酰胆碱受体拮抗剂，IC50为2.5 nM。
S2264 Artemether Artemether (SM-224, CGP 56696) 是一种抗疟药，用于治疗恶性疟疾的耐药菌株。
S2265 Artesunate (WR-256283) Artesunate (WR-256283) 是一种抗疟类药，作用于小细胞肺癌细胞系H69，IC50为< 5 μM。它是一种潜在的STAT3抑制剂，在体外对癌细胞有选择性细胞毒性作用；是有效的EXP1抑制剂。
S2304 Gramine Gramine (Donaxine) 是一种从巨型芦苇中分离出的天然吲哚生物碱，是一种活性脂联素受体（AdipoR）激动剂，对AdipoR2和AdipoR1的IC50分别为3.2 µM和4.2 µM。 禾胺也是人和小鼠 β2-Adrenergic receptor (β2-AR) 激动剂。
S2320 Luteolin Luteolin (Luteoline, Luteolol, Digitoflavone)是一种非选择性的PDE抑制剂，作用于PDE1-5，Ki分别为15.0 μM， 6.4 μM， 13.9 μM， 11.1 μM和9.5 μM。Phase 2.
S2350 Rutin Rutin (Rutoside)是在许多植物中发现的一种黄酮苷，包括Buckwheat; Tobacco; Forsythia; Hydrangea; Viola, 等。
S2372 Xanthone Xanthone (Genicide)是一种有机化合物，可以由加热水杨酸苯酯制备而得到。
S2387 Lappaconite HBr Lappaconite HBr是从Aconitum sinomontanum Nakai 提取的一种生物碱，具有抗炎作用。
S2417 20-Hydroxyecdysone 20-Hydroxyecdysone (Ecdysterone, 20E, B-ecdysone, Commisterone, Crustecdysone) 是一种自然发生的蜕皮激素，控制节肢动物的蜕皮和变态。20-Hydroxyecdysone (Ecdysterone, 20E) 可抑制 caspase 活性并通过20E核受体复合体 EcR-USP 来诱导自噬。
S2447 Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) 是一种有效的微管蛋白聚合抑制剂，IC50为3.4 μM。
S3035 Daunorubicin (RP 13057) HCl Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin)抑制DNA和RNA合成，无细胞试验中抑制DNA合成的Ki为0.02 μM。Daunorubicin 是 topoisomerase II 的抑制剂并可诱导凋亡。
S3604 Triptolide (PG490) Triptolide (PG490, NSC 163062)是一种三环氧二萜类化合物,是从中草药雷公藤中提取的免疫抑制剂。它是一种NF-κB抑制剂，抑制NF-κB转录活性，破坏p65/CBP的相互作用，减少p65蛋白。Triptolide (PG490) 可抑制 heat shock transcription factor 1 (HSF1) 的反式激活。Triptolide 可抑制 MDM2 并通过一个p53非依赖性通路来诱导凋亡。
S3628 BHQ BHQ (2,5-di-t-butyl-1,4-benzohydroquinone) 是有效的、选择性的sarco-endoplasmic reticulum Ca2+-ATPase (SERCA)抑制剂。
S3800 Lycorine hydrochloride Lycorine (Galanthidine, Amarylline, Narcissine, Licorine), a natural alkaloid extracted from the Amaryllidaceae plant family, has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer. It is an HCV inhibitor with strong activity.
S3817 Harmine hydrochloride Harmine (Telepathine)是属于β-咔啉家族化合物的一种荧光harmala生物碱，是一种高细胞渗透性的 DYRK1A 的激酶口袋结合ATP的竞争性抑制剂，与DYRK2结合IC50值高约60倍。Harmine 还可以抑制 monoamine oxidases (MAOs) 和 cdc-like kinases (CLKs)。Harmine 抑制 5-HT2A serotonin receptor 的Ki值为397 nM。
S3854 Tetrahydropalmatine hydrochloride Tetrahydropalmatine (THP, Gindarine, 1-Tetrahydropalmitine) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. It is a potent muscle relaxant.
S3883 Protopine Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.
S3892 Isopsoralen Isopsoralen (Angelicin), also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
S3941 Pinocembrin Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone)是制药工业中多功能黄酮类分子，它具有很多药学活性，如抗菌、消炎、抗氧化和抗癌活性。
S4181 Nicardipine HCl Nicardipine HCl (RS-69216,YC-93)是二氢吡啶的钙通道抑制剂，具有显著的血管扩张作用。
S4630 Diazoxide Diazoxide (Sch-6783, SRG-95213, Proglycem)在血管平滑肌和胰岛细胞中可通过增加细胞膜对钾离子的渗透性，从而激活KATP通道。
S4737 Psoralen Psoralen (Psoralene, Ficusin, Furocoumarin)是一种天然存在的呋喃香豆素，插入DNA中抑制其合成及细胞分裂。
S4776 Harmaline Harmaline, a natural occurrence β-carboline alkaloid, is a central nervous system stimulant and an acetylcholinesterase (AChR) inhibitor; also inhibits histamine N-methyltransferase.
S4859 TriacetonaMine TriacetonaMine (Tempidon, Tmpone, Odoratine, Vincubine)，作为一种哌啶酮（Piperidinone），是一种具有极弱酸性的化合物，存在于绿色植物和茶中。
S4908 SN-38 SN-38 (NK012)是CPT-11的一种活性代谢物，抑制DNA topoisomerase I，DNA合成，并造成频繁的DNA单链断裂。SN-38 可诱导自噬。
S5018 Mebhydrolin napadisylate Mebhydrolin Napadisylate (Diazoline, Diazolin, Incidal, Omeril)是一种抗组胺类药物，用于治疗过敏。
S5153 Tetrahydroberberine Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.
S5478 Dantrolene sodium
S6773 Mertansine Mertansine (DM1, Maytansinoid DM1) 是一种可与抗体结合的美登素生物碱，是一种选择性 microtubule 的抑制剂，旨在克服与maytansine相关的全身毒性并增强肿瘤特异性递送。Mertansine 可以通过linker连接到单克隆抗体上，以创建抗体偶联药物(ADC)。建议现配现用。
S7071 (+)-Bicuculline (+)-Bicuculline (d-Bicuculline)是一种竞争性GABAA受体拮抗剂，IC50为2 μM，也抑制Ca(2+)激活的钾离子通道。
S7721 Monomethyl auristatin E (MMAE) Monomethyl auristatin E (MMAE, SGD-1010)是合成的抗肿瘤药，其与单克隆抗体(MAB)有关。它也是一种能够破坏微管的试剂。
S8146 Mitomycin C Mitomycin C (Ametycine) 是一种抗肿瘤类抗生素，通过抑制DNA合成发挥作用，用于治疗各种癌症。Mitomycin C 可诱导半胱氨酸蛋白酶依赖性和Fas/CD95非依赖性的 apoptosis。
S9018 Luteoloside Luteoloside (Cynaroside, Luteolin 7-β-D-Glucopyranoside) is a member of the flavonoids family that exhibits several bioactivities including anti-microbial and anti-cancer activities. It is an inhibitor of 3C Protease of Enterovirus 71 with an IC50 value of 0.36 mM.
S9065 Songorine Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.
S9223 Talatisamine Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.
S9233 Imperialine Imperialine (Sipeimine, Kashmirine) is an alkaloid found in the bulbs of species of the genus Fritillaria.
S0564 SPDP SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with cysteine sulfhydryls. SPDP is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).
S0565 DBCO-NHS ester DBCO-NHS ester is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0566New Sulfo-SMCC sodium Sulfo-SMCC sodium是一种异双功能、不可裂解的ADC 交联剂，它由 N-羟基琥珀酰亚胺(N-hydroxysuccinimide, NHS)酯和马来酰亚胺基团与伯胺和巯基反应。
S0567 Amino-PEG4-alcohol Amino-PEG4-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. Amino-PEG4-alcohol is a non-cleavable 4-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
S0568 DBCO-acid DBCO-acid is a cleavable ADC linker applied into the synthesis of ADC linker DBCO-NHS ester and drug-linker conjugates DBCO-PEG-MMAE.
S0569 Fmoc-8-amino-3,6-dioxaoctanoic acid Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0570 Boc-NH-C6-Br Boc-NH-C6-Br is a cleavable linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0571 SPDB SPDB is a glutathione cleavable ADC linker applied into the synthesis of antibody-drug conjugate (ADCs).
S0572New SMCC SMCC (Succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate) 是一种杂双功能交联剂，包含 N-羟基琥珀酰亚胺 (NHS) 酯和马来酰亚胺基团，允许含胺和巯基的分子共价结合。SMCC 结合的抗原偶联脾细胞以诱导抗原特异性免疫反应。
S0573 N-Hydroxysulfosuccinimide sodium N-Hydroxysulfosuccinimide sodium is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0574 Fmoc-NH-PEG4-CH2CH2COOH Fmoc-NH-PEG4-CH2CH2COOH (Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid) is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0575 Boc-NH-PEG4-CH2CH2NH2 Boc-NH-PEG4-CH2CH2NH2 a cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0576 NH2-PEG2-C2-Boc NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG2-C2-Boc is a non-cleavable 2-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
S0577 6-Maleimidohexanoic acid N-hydroxysuccinimide ester 6-Maleimidohexanoic acid N-hydroxysuccinimide ester (ECMS) is a useful protective group in antibody drug conjugates (ADCs).
S0578 Hydroxy-PEG4-(CH2)2-Boc Hydroxy-PEG4-(CH2)2-Boc is a uncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0579 Boc-Gly-Gly-Phe-Gly-OH Boc-Gly-Gly-Phe-Gly-OH (GGFG) is a self-assembly of N- and C-protected tetrapeptide, a protease cleavable linker used for the antibody-drug conjugates (ADCs).
S0580 N-Boc-diethanolamine N-Boc-diethanolamine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0582 BMPS BMPS is a noncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0583 Hydroxy-PEG3-(CH2)2-Boc Hydroxy-PEG2-(CH2)2-Boc is an uncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0584 Fmoc-NH-PEG1-CH2COOH Fmoc-NH-PEG1-CH2COOH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0585 Boc-Val-Cit-OH Boc-Val-Cit-OH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0586 Succinic anhydride Succinic anhydride (SA, Succinyl Oxide, Butanedioic Anhydride) 是一种环状酸酐，可用于纤维素的均相化学改性，并用作不可裂解的ADC接头，可与其他化合物反应以将前药连接至靶向多肽的胺或羟基1组。
S0587 Mal-amido-PEG8-C2-acid Mal-amido-PEG8-C2-acid is a noncleavable ADC linker.
S0588 Propargyl-PEG6-acid Propargyl-PEG6-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0589 Mal-PEG3-NHS ester Mal-PEG3-NHS ester is a noncleavable ADC linker with a Maleimide group that is used for making antibody-drug conjugates (ADCs).
S0590 Propargyl-PEG5-amine Propargyl-PEG5-amine is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker applied into the synthesis of PROTACs.
S0591 Propargyl-PEG1-NHS ester Propargyl-PEG1-NHS ester is a noncleavable 1-unit PEG linker that can be used in antibody-drug-conjugation (ADC).
S0592 NH-bis(C1-Boc) NH-bis(C1-Boc) is an uncleavable linker that can be used for antibody-drug conjugates (ADCs).
S0593 Amino-PEG4-CH2COOH Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0594 Azido-PEG7-amine Azido-PEG7-amine is a non-cleavable 7-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0595 Hydroxy-PEG2-(CH2)2-Boc Hydroxy-PEG2-(CH2)2-Boc is an uncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0596 Amino-PEG8-Boc Amino-PEG8-Boc is a cleavable 8-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0597 m-PEG6-NHS ester m-PEG6-NHS ester is a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0598 Mal-PEG2-acid Mal-PEG2-acid is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin and its derivative cytotoxic molecule.
S0599 m-PEG7-CH2COOH m-PEG7-CH2COOH is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0600 Phe-Lys(Trt)-PAB Phe-Lys(Trt)-PAB is a cathepsin cleavable ADC linker that can be used for the antibody-drug conjugates (ADCs).
S0601 N3-PEG2-C2-NHS ester N3-PEG2-C2-NHS ester is a noncleavable 2-unit PEG linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0602 Ald-Ph-NHS ester Ald-Ph-NHS ester is an uncleavable linker for antibody-drug-conjugation (ADC).
S0603 m-PEG12-amine m-PEG12-amine 是一种基于PEG的 PROTAC linker，可用于PROTAC的合成。m-PEG12-amine 也是一种不可裂解的12个单元的PEG ADC linker，可用于抗体偶联药物(ADCs)的合成。
S0604 m-PEG11-Amine m-PEG11-Amino is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0605 Azido-PEG4-CH2-Boc Azido-PEG4-CH2-Boc is a cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
S0606 Fmoc-NH-PEG3-CH2CH2COOH Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0607 Fmoc-NH-PEG2-CH2CH2COOH Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0608 Fmoc-NH-PEG6-CH2CH2COOH Fmoc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0609 SPDV SPDV is a cleavable ADC linker that can be applied into the diagnosis and treatment of cancer or B cell proliferative disease.
S0610 SPDB-sulfo SPDB-sulfo is a glutathione cleavable ADC linker applied into the synthesis the antibody-drug conjugates (ADCs).
S0612 Propargyl-PEG7-acid Propargyl-PEG7-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0613 Bis-​PEG4-​NHS ester Bis-​PEG4-​NHS ester is a noncleavable 4-unit PEG linker for antibody-drug-conjugation (ADC).
S0616 Azido-PEG2-C2-amine Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG2-C2-amine is a non-cleavable 2-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0618 N-Boc-PEG2-bromide N-Boc-PEG2-bromide is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0620 DBCO-​C6-​acid DBCO-C6-acid is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). DBCO-C6-acid can be applied into the synthesis of carmaphycin analogues.
S0621 Tr-PEG5-OH Tr-PEG5-OH is a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0622 m-PEG4-Br m-PEG4-Br is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs) for Trastuzumab. m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency.
S0623 Bis-PEG1-NHS ester Bis-PEG1-NHS ester is a non-cleavable 1-unit PEG linker for antibody-drug-conjugation (ADC).
S0625 m-PEG7-Amine m-PEG7-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0626 DSP Crosslinker DSP Crosslinker 是一种可裂解的 ADC linker，可用于抗体-药物偶联物(ADC)的合成。
S0627New PDEC-NB PDEC-NB 是一种二硫键可切割接头，可用于合成抗体药物偶联物 (ADC)。
S0629 Ald-Ph-amido-PEG4-C2-NHS ester Ald-Ph-amido-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker for antibody-drug-conjugation (ADC).
S0630 Mal-PEG6-NHS ester Mal-PEG6-NHS ester is a non-cleavable ADC linker containing a Maleimide group, 6-unit PEG and a NHS ester.
S0631 Fmoc-NH-PEG4-CH2COOH Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0632 SIA Crosslinker SIA Crosslinker is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0633 Ald-Ph-amido-PEG4-C2-acid Ald-Ph-amido-PEG4-C2-acid is a non-cleavable linker used for the antibody-drug conjugates (ADCs).
S0634 Propargyl-PEG8-acid Propargyl-PEG8-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). The ADCs can be applied into bacterial infections caused by Gram-negative bacteria.
S0635 DBCO-amine DBCO-amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0638 Bis-​PEG2-​NHS ester Bis-PEG2-NHS ester is a non-cleavable 2-unit PEG linker used for antibody-drug-conjugation (ADC).
S0639 m-PEG2-Amine m-PEG2-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0640 NH2-PEG5-OH NH2-PEG5-OH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0641 Mal-amido-PEG2-NHS ester Mal-amido-PEG2-NHS ester is a non-cleavable ADC linker containing a maleimide group and an NHS ester. The NHS ester can label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
S0642 Azido-PEG6-amine Azido-PEG6-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0643 4-N3Pfp-NHS ester 4-N3Pfp-NHS ester is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0644 Mal-C2-NHS ester Mal-C2-NHS ester is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0645 NHPI-PEG4-C2-NHS ester NHPI-PEG4-C2-NHS ester is used as a linker for antibody-drug conjugates (ADCs).
S0647 Propargyl-PEG8-NH2 Propargyl-PEG8-NH2 is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0648 Fmoc-Asp-NH2 Fmoc-Asp-NH2 is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0649 Fmoc-NH-PEG8-CH2CH2COOH Fmoc-NH-PEG8-CH2CH2COOH is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0650 m-PEG3-CH2CH2COOH m-PEG3-CH2CH2COOH is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0651New N-Butanoyl-L-homoserine lactone N-Butyryl-L-homoserine lactone (N-Butanoyl-L-homoserine lactone, N-Butyrylhomoserine lactone, C4-HSL) 是一种可切割的ADC接头，用于合成抗体药物偶联物（ADC）。N-Butyryl-L-homoserine lactone是一种小的可扩散信号分子，参与群体感应、控制基因表达和细胞代谢。
S0652 Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0653 m-PEG9-Amine m-PEG9-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0654New Mal-​PEG4-​NHS ester Mal-PEG4-NHS ester 是一种不可切割的 ADC 接头（ADC linker），包含一个马来酰亚胺基团、4 单元 PEG 和一个 NHS 酯。
S0655New Propargyl-PEG4-NHS ester Propargyl-PEG4-NHS ester是一种4单元胺反应性PEG接头，用于抗体-药物偶联(antibody-drug-conjugation, ADC)，不可切割。
S0656 Azido-PEG9-acid Azido-PEG9-acid is a non-cleavable 9-unit PEG ADC linker applied in the synthesis of antibody-drug conjugates (ADCs).
S0657 DSS Crosslinker DSS Crosslinker (Disuccinimidyl suberate) 是一种膜可渗透的同双功能交联剂，也是一种不可裂解的ADC linker，可用于抗体药物偶联药物(ADCs)的合成。
S0658 LC-PEG8-SPDP LC-PEG8-SPDP is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0662 m-PEG8-Amine m-PEG8-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0664 m-PEG10-alcohol m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). m-PEG10-alcohol is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
S0665 m-PEG2-Tos m-PEG2-Tos is an uncleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0667 m-PEG3-Amine m-PEG3-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0668 Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
S0669 Amino-PEG2-C2-acid Amino-PEG2-C2-acid is a cleavable 3-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0670 N3-PEG3-CH2CH2-Boc N3-PEG3-CH2CH2-Boc is a cleavable 3-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
S0671 Propargyl-PEG4-C2-acid Propargyl-PEG5-acid is a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can to used to synthesize ADC inhibitors of Galectin-3.
S0672 AMAS AMAS is a non-cleavable heterobifunctional crosslinker with an NHS ester and maleimide groups. AMAS allows covalent conjugation of amine- and sulfhydryl-containing molecules.
S0673 Propargyl-C2-NHS ester Propargyl-C2-NHS ester is a non-cleavable linker used for antibody-drug-conjugation (ADC).
S0674 Amino-PEG3-C2-acid Amino-PEG3-C2-acid is a cleavable PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0675 Azide-PEG5-Tos Azide-PEG5-Tos (Azido-PEG5-OTs) 是一种可裂解的5-unit PEG ADC linker，应用于抗体-药物偶联物(ADCs)的合成。
S0676 m-PEG6-Amine m-PEG6-Amine is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0677 Fmoc-Phe-Lys(Trt)-PAB-PNP Fmoc-Phe-Lys(Trt)-PAB-PNP is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0678 BnO-PEG6-OH BnO-PEG6-OH is a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0680 PDP-C1-Ph-Val-Cit PDP-C1-Ph-Val-Cit is a cleavable ADC linker that can be used for antibody-drug conjugates (ADCs).
S0681 Amino-PEG6-alcohol Amino-PEG6-OH is a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0683 Aminoethyl-SS-ethylalcohol Aminoethyl-SS-ethylalcohol is an Alkyl-Chain-based PROTAC linker can be applied into the synthesis of PROTACs. Aminoethyl-SS-ethylalcohol is also a glutathione cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0684 Propargyl-PEG4-Tos Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0685 Propargyl-PEG2-acid Propargyl-PEG2-acid is a non-cleavable 2-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0686 NH2-PEG4-CH2CH2COOH NH2-PEG4-CH2CH2COOH is a cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0687 NH2-PEG6-Boc NH2-PEG6-Boc is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0688 m-PEG8-NHS ester m-PEG8-NHS ester is a non-cleavable 8-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0689 Bis-PEG8-acid Bis-PEG8-acid is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0691 N-Boc-PEG4-bromide N-Boc-PEG4-bromide is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0692 N3-Ph-NHS ester N3-Ph-NHS ester is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0693 Bis-PEG3-NHS ester Bis-PEG3-NHS ester is a non-cleavable 3-unit PEG linker that can be used for antibody-drug-conjugation (ADC).
S0694 Bis-PEG5-NHS ester Bis-PEG5-NHS ester is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0695 5-Maleimidovaleric acid 5-Maleimidovaleric acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0696 Propargyl-PEG2-NHBoc Propargyl-PEG2-NHBoc is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs.
S0697 Mal-PEG2-NHS ester Mal-PEG2-NHS ester is a non-cleavable ADC linker consists of a Maleimide group, 2-unit PEG and an NHS ester.
S0698 Boc-NH-PEG4-CH2CH2COOH Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be applied into the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC).
S0700 GMBS GMBS is a cross-linker with heterobifunction.
S6669 MC-Val-Cit-PAB MC-Val-Cit-PAB，也称为MC-Val-Cit-PAB-OH，是组织蛋白酶可裂解的ADC peptide linker，用于制备ADC偶联物（抗体-药物偶联物）。
S6688 Fmoc-Val-Cit-PAB Fmoc-Val-Cit-PAB (Fmoc-Val-Cit-PAB-OH)是一种可裂解的抗体偶联药物(ADC)连接桥
S0699 MC-DOXHZN hydrochloride MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin with acid-sensitive properties. Doxorubicin is a DNA topoisomerase II inhibitor.
S8670 Vipivotide tetraxetan (PSMA-617) Vipivotide tetraxetan (PSMA-617) 是一种化学修饰的 PSMA(prostate-specific membrane antigen) 抑制剂，Ki值为0.37 nM。
E0200New Trastuzumab deruxtecan Trastuzumab deruxtecan (DS-8201a, T-DXd, DS-8201) 是一种抗体药物偶联物 (antibody-drug conjugate，ADC)，由抗 HER2（人表皮生长因子受体 2）抗体和细胞毒性拓扑异构酶 I 抑制剂组成。Trastuzumab deruxtecan 显示出持久的抗肿瘤活性。
E2841New Sacituzumab govitecan Sacituzumab govitecan (IMMU-132)是一种靶向Trop-2的抗体-药物偶联物(antibody-drug conjugate, ADC)，用于传递SN-38，具有抗癌活性。
E2851New Trastuzumab Emtansine（T-DM1） Trastuzumab emtansine(T-DM1,Ado-Trastuzumab emtansine)是一种抗体药物偶联物(antibody-drug conjugate, ADC)，它结合了曲妥珠单抗的HER2靶向抗肿瘤特性和微管抑制剂DM1的细胞毒活性。