Tetrahydropalmatine hydrochloride

For research use only. Not for use in humans.

目录号:S3854 别名: Gindarine hydrochloride, 1-Tetrahydropalmitine HCl 中文名称:延胡索乙素

Tetrahydropalmatine hydrochloride Chemical Structure

CAS No. 6024-85-7

Tetrahydropalmatine (THP, Gindarine, 1-Tetrahydropalmitine) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. It is a potent muscle relaxant.

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客户使用Selleck生产的Tetrahydropalmatine hydrochloride发表文献1篇:

产品安全说明书

ADC Cytotoxin抑制剂选择性比较

生物活性

产品描述 Tetrahydropalmatine (THP, Gindarine, 1-Tetrahydropalmitine) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. It is a potent muscle relaxant.
体外研究

Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner. It suppresses activation of the NF-kB signaling pathway, which results in regulation of IL-8 expression and specifically blocks the ERK1=2 and p38 MAPK signaling pathways[1]. L-THP results in p53 independent apoptosis via down-regulating XIAP protein by inhibiting MDM2 associated with proteasome-dependent pathway and increased sensitivity of EU-4 cells against doxorubicin. L-THP causes activation of caspase and resulted in apoptosis[2]. l-THP possesses a blocking effect on dopamine D1 and D2 receptors and voltage-sensitive Ca2+ channels[3].

体内研究 l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization[3].

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[1]
- 合并
  • Cell lines: THP-1 cells
  • Concentrations: 0.2, 1, or 2 mM
  • Incubation Time: 24 h
  • Method: Cell viability is examined by MTT assay. In brief, THP-1 cells are seeded at a density of 5×104 cells/mL in 96-well plates. Each batch of cells includes a nontreated group as a control. Tetrahydropalmatine (0.2, 1, or 2 mM) and LPS (2 mg/mL) are then added to each well, after which the plates are incubated for 24 hours at 37℃ under 5% CO2. Next, MTT solutions (5 mg/mL) are added to each well, and the samples are then cultured for an additional 4 hours. The supernatant is then discarded, and 100 mL of dimethylsulfoxide is added to each well. Next, the optical density is read at 590 nm.
    (Only for Reference)
动物实验:[3]
- 合并
  • Animal Models: Kunming mice
  • Dosages: 6.25, 12.5, and 18.75 mg/kg
  • Administration: administered intragastrically
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 12 mg/mL (30.62 mM)

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 391.89
化学式

C21H25NO4.HCl

CAS号 6024-85-7
储存条件 粉状
溶于溶剂
别名 Gindarine hydrochloride, 1-Tetrahydropalmitine HCl

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID