Dopamine Receptor
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S3163 | Benztropine mesylate | 81 mg/mL | 50 mg/mL | 81 mg/mL |
| S2456 | Chlorpromazine HCl | 71 mg/mL | 71 mg/mL | 71 mg/mL |
| S2452 | Amfebutamone (Bupropion) HCl | <1 mg/mL | 8 mg/mL | <1 mg/mL |
| S3201 | Trifluoperazine 2HCl | 96 mg/mL | 88 mg/mL | 96 mg/mL |
| S2461 | Domperidone | <1 mg/mL | 48 mg/mL | 1 mg/mL |
| S4569 | Fluphenazine dihydrochloride | 100 mg/mL | 100 mg/mL | 30 mg/mL |
| S1642 | Methyldopa | <1 mg/mL | 2 mg/mL | <1 mg/mL |
| S3189 | Ropinirole HCl | 60 mg/mL | 10 mg/mL | <1 mg/mL |
| S2493 | Olanzapine | <1 mg/mL | 62 mg/mL | 9 mg/mL |
| S1763 | Quetiapine Fumarate | <1 mg/mL | 36 mg/mL | <1 mg/mL |
| S1444 | Ziprasidone HCl | <1 mg/mL | 90 mg/mL | <1 mg/mL |
| S5399 | Chlorprothixene hydrochloride | -1 mg/mL | 70 mg/mL | -1 mg/mL |
| S5714 | lurasidone | <1 mg/mL | 7 mg/mL | <1 mg/mL |
| S5624 | Paliperidone Palmitate | <1 mg/mL | 1 mg/mL | 3 mg/mL |
| S5559 | Tetrahydropalmatine | <1 mg/mL | 16 mg/mL | <1 mg/mL |
| S5153 | Tetrahydroberberine | -1 mg/mL | 6 mg/mL | -1 mg/mL |
| S5428 | Promazine hydrochloride | -1 mg/mL | 64 mg/mL | -1 mg/mL |
| S5481 | Molindone hydrochloride | -1 mg/mL | 9 mg/mL | -1 mg/mL |
| S5324 | Oxidopamine (hydrobromide) | 50 mg/mL | 50 mg/mL | 50 mg/mL |
| S4889 | Perospirone hydrochloride | -1 mg/mL | 92 mg/mL | -1 mg/mL |
| S5034 | Melitracen hydrochloride | 65 mg/mL | 65 mg/mL | 65 mg/mL |
| S1280 | Amisulpride | <1 mg/mL | 73 mg/mL | 73 mg/mL |
| S1724 | Paliperidone | <1 mg/mL | 4 mg/mL | <1 mg/mL |
| S1920 | Haloperidol | <1 mg/mL | 75 mg/mL | 8 mg/mL |
| S1771 | Chlorprothixene | <1 mg/mL | 6 mg/mL | 28 mg/mL |
| S4251 | Phenothiazine | <1 mg/mL | 40 mg/mL | <1 mg/mL |
| S4096 | Droperidol | <1 mg/mL | 76 mg/mL | <1 mg/mL |
| S3044 | Lurasidone HCl | <1 mg/mL | 1 mg/mL | <1 mg/mL |
| S2104 | Levosulpiride | <1 mg/mL | 69 mg/mL | <1 mg/mL |
| S4086 | Loxapine Succinate | <1 mg/mL | 89 mg/mL | 2 mg/mL |
| S4731 | Perphenazine | <1 mg/mL | 74 mg/mL | 74 mg/mL |
| S4151 | Penfluridol | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S2437 | Rotundine | <1 mg/mL | 8 mg/mL | <1 mg/mL |
| S4631 | Prochlorperazine dimaleate salt | <1 mg/mL | 74 mg/mL | 2 mg/mL |
| S4257 | Alizapride HCl | 70 mg/mL | 42 mg/mL | <1 mg/mL |
| S4655 | Sulpiride | <1 mg/mL | 68 mg/mL | <1 mg/mL |
| S1789 | Tetrabenazine (Xenazine) | <1 mg/mL | 58 mg/mL | 32 mg/mL |
| S4219 | Azaperone | <1 mg/mL | 65 mg/mL | 34 mg/mL |
| S4289 | Metoclopramide HCl | 67 mg/mL | 67 mg/mL | 67 mg/mL |
| S5066 | Pramipexole dihydrochloride | -1 mg/mL | 56 mg/mL | -1 mg/mL |
| S3664 | Flupenthixol dihydrochloride | 100 mg/mL | 100 mg/mL | 30 mg/mL |
| S3656 | Piribedil | <1 mg/mL | 59 mg/mL | 59 mg/mL |
| S1726 | Levodopa | <1 mg/mL | <1 mg/mL | <1 mg/mL |
| S2451 | Amantadine HCl | 38 mg/mL | 38 mg/mL | 38 mg/mL |
| S2011 | Pramipexole 2HCl Monohydrate | 60 mg/mL | 41 mg/mL | <1 mg/mL |
| S2460 | Pramipexole | <1 mg/mL | 42 mg/mL | 42 mg/mL |
| S2529 | Dopamine HCl | 38 mg/mL | 38 mg/mL | <1 mg/mL |
| S4000 | Pergolide Mesylate | 82 mg/mL | 10 mg/mL | <1 mg/mL |
| S4618 | Fenoldopam mesylate | <1 mg/mL | 80 mg/mL | <1 mg/mL |
| S7993 | SKF38393 HCl | <1 mg/mL | 58 mg/mL | 6 mg/mL |
| S4639 | Brexpiprazole | <1 mg/mL | 24 mg/mL | <1 mg/mL |
| S2168 | PD128907 HCl | 50 mg/mL | 12 mg/mL | <1 mg/mL |
| S4274 | Rotigotine | <1 mg/mL | 63 mg/mL | 63 mg/mL |
| S4732 | MPTP hydrochloride | 41 mg/mL | 20 mg/mL | 41 mg/mL |
| S8097 | C-DIM12 | <1 mg/mL | 71 mg/mL | 71 mg/mL |
| S3188 | (+,-)-Octopamine HCl | 38 mg/mL | 38 mg/mL | 11 mg/mL |
特异性亚型抑制剂
- Dopamine Receptor抑制剂（56）
- 新Dopamine Receptor产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S3163 |
Benztropine mesylateBenztropine mesylate是一种多巴胺转运蛋白抑制剂，IC50为118 nM。 |
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| S2456 |
Chlorpromazine HClChlorpromazine HCl是一种多巴胺和钾离子通道抑制剂，对内向整流钾电流和与时间无关的外向电流IC50分别为6.1和16 μM。 |
Low-micromolar amounts of chlorpromazine inhibit SARS-CoV-induced cytopathology. Vero E6 cells in 96-well plates were infected with SARS-CoV isolate Frankfurt-1 (MOI, 0.005) in the presence of 0 to 16 μM CPZ (B), given at t of +1 h p.i. Cells were incubated for 3 days, and viability was monitored using an MTS assay. In parallel, potential compound cytotoxicity was monitored in mock-infected Vero E6 cells. Graphs show the results (averages and SD) of a representative experiment that was performed in quadruplicate. All experiments were repeated at least twice. For each compound, the EC50, CC50, and SI values are given. |
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| S2452 |
Amfebutamone (Bupropion) HClAmfebutamone (Bupropion) HCl是一种选择性去甲肾上腺素-多巴胺再摄取的抑制剂，IC50分别为6.5和3.4μM。 |
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| S3201 |
Trifluoperazine 2HClTrifluoperazine 2HCl是一种多巴胺D2受体抑制剂，IC50为1.1 nM。 |
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| S2461 |
DomperidoneDomperidone 是一种多巴胺受体抑制剂，是一种抗多巴胺试剂。 |
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| S4569 |
Fluphenazine dihydrochlorideFluphenazine dihydrochloride是吩噻嗪类的D1DR和D2DR抑制剂。它能够抑制组胺H1受体。 |
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| S1642 |
MethyldopaMethyldopa 是DOPA 脱羧酶竞争性抑制剂，ED50为21.8 mg/kg。 |
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| S3189 |
Ropinirole HClRopinirole HCl是一种选择性的D2受体抑制剂，IC50为29 nM。 |
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| S2493 |
OlanzapineOlanzapine是一种高亲和力的5-HT2 5-羟色胺和多巴胺D2受体拮抗剂。 |
Olanzapine and aripiprazole differentially regulate cellular glucose uptake of PBMC. Bar graphs depict cellular glucose uptake assessed by 18F-FDG in PBMC after 72 h of stimulation with the indicated concentrations of olanzapine (Olan, A) or aripiprazole (Arip, B) relative to corresponding DMSO controls (Ctrl) and normalized to protein content. Data are depicted as mean ± SD. P-values were computed by one-way ANOVA followed by Dunnett's Multiple Comparison Test. ***P < 0.001, **P < 0.01, *P < 0.05 versus control; results were obtained from n ¼ 4e6 independent cell isolations measured in duplicate.
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| S1763 |
Quetiapine FumarateQuetiapine Fumarate是一种非典型抗精神病药物，用于治疗精神分裂症，双相I型躁狂，双相II型抑郁症，双相I型抑郁症。对多种神经递质受体如serotonin, dopamine, histamine和adrenergic receptors有亲和力。 |
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| S1444 |
Ziprasidone HClZiprasidone HCl 是一类有效的dopamine 和 serotonin (5-HT) receptor的拮抗剂，用于精神分裂症以及双向性障碍的治疗。 |
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| S5399New |
Chlorprothixene hydrochlorideChlorprothixene HCl is the hydrochloride salt form of chlorprothixene, a typical antipsychotic drug of the thioxanthene (tricyclic) class. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. |
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| S5714New |
lurasidoneLurasidone is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors. |
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| S5624New |
Paliperidone PalmitatePaliperidone Palmitate is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. |
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| S5559New |
TetrahydropalmatineTetrahydropalmatine, a plant alkaloid used as an ingredient in dietary supplement products, is a potent and selective D1 receptor antagonist. |
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| S5153New |
TetrahydroberberineTetrahydroberberine is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors. |
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| S5428New |
Promazine hydrochloridePromazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects. |
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| S5481New |
Molindone hydrochlorideMolindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist. |
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| S5324New |
Oxidopamine (hydrobromide)Oxidopamine is a neurotoxic synthetic organic compound that acts as an antagonist of the neurotransmitter dopamine with potential antineoplastic activity. |
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| S4889New |
Perospirone hydrochloridePerospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. |
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| S5034New |
Melitracen hydrochlorideMelitracen hydrochloride是一种潜在的dopamine D1/2 receptor拮抗剂，具有抗抑郁作用。 |
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| S1280 |
AmisulprideAmisulpride是一种非典型的抗精神病药物，用于治疗精神病的精神分裂症和双相情感障碍的躁狂发作。 |
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| S1724 |
PaliperidonePaliperidone，作为 Risperidone主要的活性代谢物，是一种高效的serotonin-2A 和dopamine-2 receptor 拮抗剂，用于治疗精神分裂症。 |
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| S1920 |
HaloperidolHaloperidol 是一种丁酰苯类的抗精神病药。 |
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| S1771 |
ChlorprothixeneChlorprothixene与多巴胺和组织胺受体（如D1， D2， D3， D5， H1， 5-HT2， 5-HT6和5-HT7）具有强结合力， Ki值分别为18nM， 2.96 nM， 4.56 nM， 9 nM， 3.75 nM， 9.4 nM， 3 nM和5.6 nM。 |
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| S4251 |
PhenothiazinePhenothiazine是多巴胺-2(D2)受体拮抗剂，因此能够降低多巴胺在大脑中的作用。 |
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| S4096 |
DroperidolDroperidol在边缘系统中有效拮抗多巴胺受体亚型2(D2DR)。 |
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| S3044 |
Lurasidone HClLurasidone HCl是一种非典型的抗精神病药物，抑制D2， 5-HT2A， 5-HT7， 5-HT1A和去甲肾上腺素α2C，IC50分别为1.68 nM， 2.03 nM， 0.495 nM， 6.75 nM和10.8 nM。 |
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| S2104 |
LevosulpirideLevosulpiride是一种选择性D2多巴胺受体拮抗剂，用作抗精神病药和促动力剂。 |
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| S4086 |
Loxapine SuccinateLoxapine Succinate是D2DR和D4DR抑制剂,5-羟色胺受体拮抗剂，也是Dibenzoxazepine类的抗精神病试剂。 |
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| S4731 |
PerphenazinePerphenazine是一种吩噻嗪衍生物，它是多巴胺受体阻滞剂，具有止吐和治疗精神疾病的特性。 |
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| S4151 |
PenfluridolPenfluridol是一种高效的，第一代二苯丁哌啶类抗精神病药物。 |
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| S2437 |
RotundineRotundine是一种选择性多巴胺D1受体拮抗剂， IC50为166 nM。 |
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| S4631 |
Prochlorperazine dimaleate saltProchlorperazine是抗精神病药物中属于吩噻嗪类的多巴胺受体D2拮抗剂。 |
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| S4257 |
Alizapride HClAlizapride在以外消旋混合物服用时，作为多巴胺拮抗剂促肠胃运动和止吐治疗癌症化疗引起的恶心和呕吐。 |
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| S4655 |
SulpirideSulpiride是一种多巴胺D2受体拮抗剂。在临床治疗中，它被用作抗抑郁剂、安定药和助消化药。 |
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| S1789 |
Tetrabenazine (Xenazine)Tetrabenazine(Nitoman, Xenazine)主要是一种可逆的、高亲和力的突触前神经元的颗粒小泡吸收单胺的抑制剂，选择性与VMAT-2结合。也能阻止dopamine D2 receptors，但亲和力相对于对VMAT-2的亲和力弱1000倍。 |
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| S4219 |
AzaperoneAzaperone 是一种吡啶哌嗪和丁酰苯类抗精神病药，具有镇静和止吐的效果，主要是在兽医上用作镇静剂。它是Dopamine receptors的拮抗剂，能够透过血脑屏障，结合D1和D2受体。 |
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| S4289 |
Metoclopramide HClMetoclopramide HCl是一种选择性的 dopamine D2 receptor 拮抗剂，用于治疗恶心和呕吐。 |
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| S5066New |
Pramipexole dihydrochloridePramipexole dihydrochloride是非麦角灵类的dopamine激动剂，用于治疗帕金森氏病和多动腿综合征，对D2S受体、D2L受体、D3和D4受体的Ki值分别为3.9 nM, 2.2 nM, 0.5 nM 和5.1 nM。 |
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| S3664New |
Flupenthixol dihydrochlorideFlupentixol是一种抗精神病安定药物，是D1 and D2多巴胺受体的强效拮抗剂，也是α肾上腺素能受体的拮抗剂。 |
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| S3656New |
PiribedilPiribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties. |
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| S1726 |
LevodopaLevodopa 是多巴胺,，肾上腺素以及去甲肾上腺素的前体，具有抗帕金森病的特性。 |
(A) A focused screening of Aβ generation in response to levodopa, piribedil, bromocriptine or carbidopa at indicated concentrations in SK-N-SH cells. Data are mean ± s.e.m., n = 3-4. *p < 0.05; ***p < 0.001 versus the control of each group.
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| S2451 |
Amantadine HClAmantadine HCl用于治疗或预防某些病毒引起的呼吸道感染。 |
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| S2011 |
Pramipexole 2HCl MonohydratePramipexole 2HCl Monohydrate 是一种部分/全部D2S， D2L， D3， D4受体激动剂，Ki为3.9， 2.2， 0.5， 5.1 nM。 |
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| S2460 |
PramipexolePramipexole是部分/全部D2S， D2L， D3， D4受体激动剂，作用于D2S， D2L， D3， D4受体，Ki分别为3.9， 2.2， 0.5和5.1 nM。 |
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| S2529 |
Dopamine HClDopamine HCl 是一种广泛存在于各种动物的儿茶酚胺类神经递质，是多巴胺D1-5受体激动剂。 |
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| S4000 |
Pergolide MesylatePergolide Mesylate是一种抗震颤麻痹剂，作为dopaminergic（多巴胺能）激动剂。 |
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| S4618 |
Fenoldopam mesylateFenoldopam是一种选择性的多巴胺受体（dopamine-1 receptor）激动剂，具有利尿特性。它可以通过小动脉的血管舒张降低血压。 |
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| S7993 |
SKF38393 HClSKF38393 HCl是一种选择性dopamine D1/D5 receptor激动剂。 |
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| S4639 |
BrexpiprazoleBrexpiprazole是一种新型的多巴胺受体D2和5-羟色胺1A受体的部分激动剂，同时也是5-羟色胺2A受体和去甲肾上腺素alpha1B、alpha2C受体的拮抗剂。其对D2L, 5-HT1A, 5-HT2A, α1B受体和 α2C受体的Ki值分别为 0.3, 0.12, 0.47, 0.17 和 0.59 nM。 |
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| S2168 |
PD128907 HClPD128907 HCl是一种有效的，选择性的多巴胺D3受体激动剂，EC50为0.64 nM，比作用于多巴胺D2受体的选择性高53倍。 |
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| S4274 |
RotigotineRotigotine是一种dopamine receptor的激动剂，用于帕金森氏症和不宁腿综合征的治疗。 |
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| S4732 |
MPTP hydrochlorideMPTP HCl是一种多巴胺能的神经毒素，能在帕金森动物模型中选择性破坏多巴胺能神经元。 |
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| S8097 |
C-DIM12C-DIM12是Nurr1的激活剂，刺激膀胱癌细胞和肿瘤中Nurr1所介导的细胞凋亡、抑制胶质细胞中对NF-κB依赖的基因表达。 |
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| S3188 |
(+,-)-Octopamine HCl(+,-)-Octopamine HCl,是一种生命必需的一元胺，结构上与去甲肾上腺素相关, 在无脊椎动物中作为一种神经激素，神经调节物质以及神经递质。 |
