Dopamine Receptor

信号通路图

研究领域

抑制剂选择性比较

特异性亚型抑制剂

Dopamine Receptor产品

所有产品(72) Dopamine Receptor抑制剂(11) Dopamine Receptor拮抗剂(40) Dopamine Receptor激动剂(17) Dopamine Receptor调节剂(1)

目录号	产品描述	文献引用	实验数据
S3163	Benztropine mesylate Benztropine mesylate是一种多巴胺转运蛋白抑制剂，IC50为118 nM。
S2456	Chlorpromazine HCl Chlorpromazine HCl (Sonazine)是一种多巴胺和钾离子通道抑制剂，对内向整流钾电流和与时间无关的外向电流IC50分别为6.1和16 μM。	Drug Metab Dispos, 2020, 48(8):613-621 bioRxiv, 2020, 2020/9/20.4.7.30734 J Virol, 2018, 92(24)	Low-micromolar amounts of chlorpromazine inhibit SARS-CoV-induced cytopathology. Vero E6 cells in 96-well plates were infected with SARS-CoV isolate Frankfurt-1 (MOI, 0.005) in the presence of 0 to 16 μM CPZ (B), given at t of +1 h p.i. Cells were incubated for 3 days, and viability was monitored using an MTS assay. In parallel, potential compound cytotoxicity was monitored in mock-infected Vero E6 cells. Graphs show the results (averages and SD) of a representative experiment that was performed in quadruplicate. All experiments were repeated at least twice. For each compound, the EC50, CC50, and SI values are given.
S2452	Amfebutamone (Bupropion) HCl Amfebutamone (Bupropion) HCl是一种选择性去甲肾上腺素-多巴胺再摄取的抑制剂，IC50分别为6.5和3.4μM。	Front Microbiol, 2020, 10:2936 G3 (Bethesda), 2014, 4(6):1081-9 Georgia State University, 2014, Chaquettea Felton
S3201	Trifluoperazine 2HCl Trifluoperazine (SKF5019) 是一种多巴胺D2受体抑制剂，IC50为1.1 nM。	Toxicol Lett, 2020, S0378-4274(20)30494-X
S2461	Domperidone Domperidone 是一种多巴胺受体抑制剂，是一种抗多巴胺试剂。
S4569	Fluphenazine dihydrochloride Fluphenazine dihydrochloride (Prolixin)是吩噻嗪类的D1DR和D2DR抑制剂。它能够抑制组胺H1受体。	bioRxiv, 2020, 2020/9/20.4.7.30734 Methods Mol Biol, 2017, 1513:119-140
S5856	Trifluoperazine Trifluoperazine (NSC-17474, RP-7623, SKF-5019) 是FDA认证的抗精神病药，用于治疗精神分裂症。它是calmodulin (CaM)和Dopamine D2 receptor抑制剂，对D2受体的IC50值为1.2 nM。	Apoptosis, 2020, 25(11-12):853-863 Toxicol Lett, 2020, S0378-4274(20)30494-X
S1642	Methyldopa Methyldopa 是DOPA 脱羧酶竞争性抑制剂，ED50为21.8 mg/kg。
S5796	Vanoxerine dihydrochloride Vanoxerine (GBR-12909) 是一种有效的、选择性的多巴胺摄取（dopamine uptake）抑制剂。
S3854	Tetrahydropalmatine hydrochloride Tetrahydropalmatine (THP, Gindarine, 1-Tetrahydropalmitine) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. It is a potent muscle relaxant.
S3189	Ropinirole HCl Ropinirole (SKF-101468A)是一种选择性的D2受体抑制剂，IC50为29 nM。
S2493	Olanzapine Olanzapine (LY170053)是一种高亲和力的5-HT2 5-羟色胺和多巴胺D2受体拮抗剂。	Cell, 2020, S0092-8674(20)31394-5 Acta Pharmacol Sin, 2020, 10.1038/s41401-020-0378-6 Int J Pharm, 2019, 560:294-305	Punctuates of LC3 proteins in olanzapine-treated T98 and LN229 cells. Cells were incubated with olanzapine (0, 0.1M, 0.2mM) for 48h and then stained with the anti-LC3 antibody. Cells were examined by fluorescence confocal microscopy. Green: FITC-labeled LC3; Blue: DAPI-labeled nucleus. Magnification: x 400
S1763	Quetiapine Fumarate Quetiapine Fumarate (ICI-204636) 是一种非典型抗精神病药物，用于治疗精神分裂症，双相I型躁狂，双相II型抑郁症，双相I型抑郁症。对多种神经递质受体如serotonin, dopamine, histamine和adrenergic receptors有亲和力。	J Cancer Res Clin Oncol, 2019, 145(6):1495-1507 Toxicol Lett, 2019, 313:77-90
S1444	Ziprasidone HCl Ziprasidone HCl (CP-88059) 是一类有效的dopamine 和 serotonin (5-HT) receptor的拮抗剂，用于精神分裂症以及双向性障碍的治疗。	Nature, 2018, 560(7718):372-376 Sci Rep, 2018, 8(1):15753 Sci Rep, 2017, 7(1):8491	a, Quantification of sterol levels in OPCs (oligodendrocyte progenitor cells) treated with the indicated molecules at 2 μM.
S6887^New	Clozapine N-oxide Clozapine N-oxide (CNO) 是一种 Clozapine (GLXC-06516) 的代谢产物，是 human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs) 的激动剂。Clozapine 是一种有效的 dopamine (DA) 拮抗剂和选择性的 muscarinic M4 receptor 的激动剂。
S0476^New	SCH-23390 hydrochloride SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride,SCH-23390 HCl) 是一种高效且选择性强的 dopamine D1-like receptor 的拮抗剂，对于D1和D5多巴胺受体亚型的Ki值分别为0.2 nM和0.3 nM。SCH-23390 hydrochloride 是一种有效的 h5-HT2C receptors 的激动剂，Ki值为9.3 nM。SCH-23390 hydrochloride 可直接抑制 G protein-coupled inwardly rectifying potassium (GIRK) channels，IC50值为268 nM。
S1280	Amisulpride Amisulpride (DAN-2163)是一种非典型的抗精神病药物，用于治疗精神病的精神分裂症和双相情感障碍的躁狂发作。
S1724	Paliperidone Paliperidone，作为 Risperidone主要的活性代谢物，是一种高效的serotonin-2A 和dopamine-2 receptor 拮抗剂，用于治疗精神分裂症。
S1920	Haloperidol Haloperidol 是一种丁酰苯类的抗精神病药。
S1771	Chlorprothixene Chlorprothixene与多巴胺和组织胺受体（如D1， D2， D3， D5， H1， 5-HT2， 5-HT6和5-HT7）具有强结合力， K_i值分别为18nM， 2.96 nM， 4.56 nM， 9 nM， 3.75 nM， 9.4 nM， 3 nM和5.6 nM。	Sci Rep, 2018, 8(1):15753
S4251	Phenothiazine Phenothiazine (ENT 38) 是多巴胺-2(D2)受体拮抗剂，因此能够降低多巴胺在大脑中的作用。
S4096	Droperidol Droperidol (NSC 169874) 在边缘系统中有效拮抗多巴胺受体亚型2(D2DR)。	Sci Rep, 2018, 8(1):15753
S3044	Lurasidone HCl Lurasidone (SM-13496)是一种非典型的抗精神病药物，抑制D2， 5-HT2A， 5-HT7， 5-HT1A和去甲肾上腺素α2C，IC50分别为1.68 nM， 2.03 nM， 0.495 nM， 6.75 nM和10.8 nM。
S2104	Levosulpiride Levosulpiride是一种选择性D2多巴胺受体拮抗剂，用作抗精神病药和促动力剂。	Sci Rep, 2018, 8(1):15753
S4086	Loxapine Succinate Loxapine Succinate是D2DR和D4DR抑制剂,5-羟色胺受体拮抗剂，也是Dibenzoxazepine类的抗精神病试剂。
S5741	Quetiapine Quetiapine 是一种非典型的抗精神病药，用于治疗精神分裂症、双相情感障碍和重度抑郁症。Quetiapine 是一种5-HT receptors 激动剂，对人 5-HT1A receptor 的pEC50值为4.77。Quetiapine 是一种 dopamine receptor 拮抗剂，对人 D2 receptor 的pIC50值为6.33。Quetiapine 对人 D2, HT1A, 5-HT2A, 5-HT2C receptor 具有中到高亲和力，pKis值为7.23、5.74、7.54、5.55。
S5559	Tetrahydropalmatine Tetrahydropalmatine (Rotundine), a plant alkaloid used as an ingredient in dietary supplement products, is a potent and selective D1 receptor antagonist.
S4731	Perphenazine Perphenazine (Trilafon, Etaperazine)是一种吩噻嗪衍生物，它是多巴胺受体阻滞剂，具有止吐和治疗精神疾病的特性。
S5153	Tetrahydroberberine Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.
S5324	Oxidopamine (hydrobromide) Oxidopamine (6-hydroxydopamine, 6-OHDA, 2,4,5-trihydroxyphenethylamine) is a neurotoxic synthetic organic compound that acts as an antagonist of the neurotransmitter dopamine with potential antineoplastic activity.
S4889	Perospirone hydrochloride Perospirone (SM-9018) is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.
S5399	Chlorprothixene hydrochloride Chlorprothixene HCl (Minithixen hydrochloride, Truxal hydrochloride, NSC 169899, NSC 56379, NSC 78193) is the hydrochloride salt form of chlorprothixene, a typical antipsychotic drug of the thioxanthene (tricyclic) class. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.
S5565	Triflupromazine hydrochloride Triflupromazine hydrochloride (Fluopromazine) is an antipsychotic medication of the phenothiazine class.	bioRxiv, 2020, 2020/9/20.4.7.30734
S4151	Penfluridol Penfluridol (TLP-607) 是一种高效的，第一代二苯丁哌啶类抗精神病药物。
S5481	Molindone hydrochloride Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist.
S2437	Rotundine Rotundine是一种选择性多巴胺D1受体拮抗剂， IC50为166 nM。	J Med Virol, 2019, 91(8):1440-1447
S4631	Prochlorperazine dimaleate salt Prochlorperazine dimaleate (Prochlorperazin, Compazine, Capazine, Stemetil)是抗精神病药物中属于吩噻嗪类的多巴胺受体D2拮抗剂。	F1000Res, 2016, 5:150
S4257	Alizapride HCl Alizapride在以外消旋混合物服用时，作为多巴胺拮抗剂促肠胃运动和止吐治疗癌症化疗引起的恶心和呕吐。
S4655	Sulpiride Sulpiride (Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil)是一种多巴胺D2受体拮抗剂。在临床治疗中，它被用作抗抑郁剂、安定药和助消化药。	Nat Commun, 2020, 11(1):941
S5714	lurasidone Lurasidone (SM-13496) is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.
S5034	Melitracen hydrochloride Melitracen hydrochloride (Thymeol)是一种潜在的dopamine D1/2 receptor拮抗剂，具有抗抑郁作用。
S1789	Tetrabenazine (Xenazine) Tetrabenazine(Nitoman, Xenazine)主要是一种可逆的、高亲和力的突触前神经元的颗粒小泡吸收单胺的抑制剂，选择性与VMAT-2结合。也能阻止dopamine D2 receptors，但亲和力相对于对VMAT-2的亲和力弱1000倍。
S6410	Clemizole Clemizole是第一代组胺受体(H1 receptor)拮抗剂，是有效的行为性和电生理癫痫活性的抑制剂。它对丙型肝炎的感染具有潜在疗效，能有效地抑制TRPC5离子通道。
S4219	Azaperone Azaperone (NSC 170976) 是一种吡啶哌嗪和丁酰苯类抗精神病药，具有镇静和止吐的效果，主要是在兽医上用作镇静剂。它是Dopamine receptors的拮抗剂，能够透过血脑屏障，结合D1和D2受体。
S6455	Clebopride (malate) Clebopride是dopamine拮抗剂，用于治疗功能性肠胃失调如恶心或呕吐。
S5428	Promazine hydrochloride Promazine (Romtiazin, Sinophenin) is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects.
S5624	Paliperidone Palmitate Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.
S5749	Chlorpromazine Chlorpromazine (CPZ) 是一种低效的典型抗精神病药，用于治疗精神病如精神分裂症。Chlorpromazine (CPZ) 在体外可抑制 5-HT(2A) receptor 和 dopamine D2。Chlorpromazine (CPZ) 还可抑制 sodium channel，并阻断HERG potassium channels，对应的IC50值为21.6 μM。	Biomaterials, 2020, 232:119701 Drug Metab Dispos, 2020, 48(8):613-621 bioRxiv, 2020, 2020/9/20.4.7.30734
S9509	Tiapride Hydrochloride Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.
S4289	Metoclopramide HCl Metoclopramide HCl是一种选择性的 dopamine D2 receptor 拮抗剂，用于治疗恶心和呕吐。
S5862	Metoclopramide Metoclopramide是一种多巴胺拮抗剂，用于治疗恶心呕吐。
S0104^New	Pardoprunox (SLV-308) hydrochloride Pardoprunox (SLV-308, DU-126891, SME-308) hydrochloride (HCl) 是一种有效的部分 dopamine D2 receptor 的激动剂，对应的pEC50值为8.0，也是诱导 [³⁵S]GTPγS binding 的部分激动剂，对应的pEC50值为9.2，和 serotonin 5-HT1A receptor 的激动剂，pEC50值为6.3。
S1726	Levodopa Levodopa 是多巴胺,，肾上腺素以及去甲肾上腺素的前体，具有抗帕金森病的特性。	PLoS One, 2017, 12(3):e0173240	(A) A focused screening of Aβ generation in response to levodopa, piribedil, bromocriptine or carbidopa at indicated concentrations in SK-N-SH cells. Data are mean ± s.e.m., n = 3-4. p < 0.05; **p < 0.001 versus the control of each group.
S2451	Amantadine HCl Amantadine HCl (1-adamantanamine)用于治疗或预防某些病毒引起的呼吸道感染。	Adv Ther (Weinh), 2020, 2000034
S2011	Pramipexole 2HCl Monohydrate Pramipexole 2HCl Monohydrate 是一种部分/全部D2S， D2L， D3， D4受体激动剂，K_i为3.9， 2.2， 0.5， 5.1 nM。	Autophagy, 2016, 12(12):2374-2385
S2460	Pramipexole Pramipexole (SND 919)是部分/全部D2S， D2L， D3， D4受体激动剂，作用于D2S， D2L， D3， D4受体，K_i分别为3.9， 2.2， 0.5和5.1 nM。
S2529	Dopamine HCl Dopamine HCl 是一种广泛存在于各种动物的儿茶酚胺类神经递质，是多巴胺D1-5受体激动剂。	Cancer Commun (Lond), 2020, 10.1002/cac2.12103 Brain, 2019, 142(3):700-718
S5849	Cariprazine HCl Cariprazine (RGH-188)是一种新型二代抗精神病药物，是偏好于D3受体的dopamine D2/D3 receptor部分激动剂。
S3664	Flupenthixol dihydrochloride Flupentixol是一种抗精神病安定药物，是D1 and D2多巴胺受体的强效拮抗剂，也是α肾上腺素能受体的拮抗剂。
S3821	Nuciferine Nuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities.
S4618	Fenoldopam mesylate Fenoldopam (SKF 82526, Corlopam)是一种选择性的多巴胺受体（dopamine-1 receptor）激动剂，具有利尿特性。它可以通过小动脉的血管舒张降低血压。
S7993	SKF38393 HCl SKF38393 HCl是一种选择性dopamine D1/D5 receptor激动剂。
S4639	Brexpiprazole Brexpiprazole (OPC-34712)是一种新型的多巴胺受体D2和5-羟色胺1A受体的部分激动剂，同时也是5-羟色胺2A受体和去甲肾上腺素alpha1B、alpha2C受体的拮抗剂。其对D_2L, 5-HT_1A, 5-HT_2A, α_1B受体和 α_2C受体的Ki值分别为 0.3, 0.12, 0.47, 0.17 和 0.59 nM。
S3656	Piribedil Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
S2168	PD128907 HCl PD128907 HCl是一种有效的，选择性的多巴胺D3受体激动剂，EC50为0.64 nM，比作用于多巴胺D2受体的选择性高53倍。
S5842	Cabergoline Cabergoline (FCE-21336)是一种长效多巴胺（dopamine）激动剂和催乳激素（prolactin）抑制剂。
S4274	Rotigotine Rotigotine是一种dopamine receptor的激动剂，用于帕金森氏症和不宁腿综合征的治疗。	Cell Death Dis, 2019, 10(9):649
S5066	Pramipexole dihydrochloride Pramipexole dihydrochloride (SND919)是非麦角灵类的dopamine激动剂，用于治疗帕金森氏病和多动腿综合征，对D2S受体、D2L受体、D3和D4受体的Ki值分别为3.9 nM, 2.2 nM, 0.5 nM 和5.1 nM。
S4933^New	Lithium carbonate Lithium carbonate (Li2CO3)是一种无机化合物，可治疗和预防情绪障碍，尤其是躁郁症bipolar disorder (BD)的有价值和有效的药剂。Lithium carbonate 能够改变 D2 dopamine receptors 的反应。
S4732	MPTP hydrochloride MPTP HCl是一种多巴胺能的神经毒素，能在帕金森动物模型中选择性破坏多巴胺能神经元。MPTP hydrochloride可诱导凋亡。	J Neuroinflammation, 2020, 17(1):272
S8097	C-DIM12 C-DIM12是Nurr1的激活剂，刺激膀胱癌细胞和肿瘤中Nurr1所介导的细胞凋亡、抑制胶质细胞中对NF-κB依赖的基因表达。	Front Mol Neurosci, 2020, 23724 Cell Death Dis, 2018, 9(3):411
S3188	(+,-)-Octopamine HCl (+,-)-Octopamine HCl,是一种生命必需的一元胺，结构上与去甲肾上腺素相关, 在无脊椎动物中作为一种神经激素，神经调节物质以及神经递质。

目录号	产品描述	文献引用	实验数据
S3163	Benztropine mesylate Benztropine mesylate是一种多巴胺转运蛋白抑制剂，IC50为118 nM。
S2456	Chlorpromazine HCl Chlorpromazine HCl (Sonazine)是一种多巴胺和钾离子通道抑制剂，对内向整流钾电流和与时间无关的外向电流IC50分别为6.1和16 μM。	Drug Metab Dispos,2020, 48(8):613-621 bioRxiv,2020, 2020/9/20.4.7.30734 J Virol,2018, 92(24)	Low-micromolar amounts of chlorpromazine inhibit SARS-CoV-induced cytopathology. Vero E6 cells in 96-well plates were infected with SARS-CoV isolate Frankfurt-1 (MOI, 0.005) in the presence of 0 to 16 μM CPZ (B), given at t of +1 h p.i. Cells were incubated for 3 days, and viability was monitored using an MTS assay. In parallel, potential compound cytotoxicity was monitored in mock-infected Vero E6 cells. Graphs show the results (averages and SD) of a representative experiment that was performed in quadruplicate. All experiments were repeated at least twice. For each compound, the EC50, CC50, and SI values are given.
S2452	Amfebutamone (Bupropion) HCl Amfebutamone (Bupropion) HCl是一种选择性去甲肾上腺素-多巴胺再摄取的抑制剂，IC50分别为6.5和3.4μM。	Front Microbiol,2020, 10:2936 G3 (Bethesda),2014, 4(6):1081-9 Georgia State University,2014, Chaquettea Felton
S3201	Trifluoperazine 2HCl Trifluoperazine (SKF5019) 是一种多巴胺D2受体抑制剂，IC50为1.1 nM。	Toxicol Lett,2020, S0378-4274(20)30494-X
S2461	Domperidone Domperidone 是一种多巴胺受体抑制剂，是一种抗多巴胺试剂。
S4569	Fluphenazine dihydrochloride Fluphenazine dihydrochloride (Prolixin)是吩噻嗪类的D1DR和D2DR抑制剂。它能够抑制组胺H1受体。	bioRxiv,2020, 2020/9/20.4.7.30734 Methods Mol Biol,2017, 1513:119-140
S5856	Trifluoperazine Trifluoperazine (NSC-17474, RP-7623, SKF-5019) 是FDA认证的抗精神病药，用于治疗精神分裂症。它是calmodulin (CaM)和Dopamine D2 receptor抑制剂，对D2受体的IC50值为1.2 nM。	Apoptosis,2020, 25(11-12):853-863 Toxicol Lett,2020, S0378-4274(20)30494-X
S1642	Methyldopa Methyldopa 是DOPA 脱羧酶竞争性抑制剂，ED50为21.8 mg/kg。
S5796	Vanoxerine dihydrochloride Vanoxerine (GBR-12909) 是一种有效的、选择性的多巴胺摄取（dopamine uptake）抑制剂。
S3854	Tetrahydropalmatine hydrochloride Tetrahydropalmatine (THP, Gindarine, 1-Tetrahydropalmitine) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. It is a potent muscle relaxant.
S3189	Ropinirole HCl Ropinirole (SKF-101468A)是一种选择性的D2受体抑制剂，IC50为29 nM。

目录号	产品描述	文献引用	实验数据
S2493	Olanzapine Olanzapine (LY170053)是一种高亲和力的5-HT2 5-羟色胺和多巴胺D2受体拮抗剂。	Cell, 2020, S0092-8674(20)31394-5 Acta Pharmacol Sin, 2020, 10.1038/s41401-020-0378-6 Int J Pharm, 2019, 560:294-305	Punctuates of LC3 proteins in olanzapine-treated T98 and LN229 cells. Cells were incubated with olanzapine (0, 0.1M, 0.2mM) for 48h and then stained with the anti-LC3 antibody. Cells were examined by fluorescence confocal microscopy. Green: FITC-labeled LC3; Blue: DAPI-labeled nucleus. Magnification: x 400
S1763	Quetiapine Fumarate Quetiapine Fumarate (ICI-204636) 是一种非典型抗精神病药物，用于治疗精神分裂症，双相I型躁狂，双相II型抑郁症，双相I型抑郁症。对多种神经递质受体如serotonin, dopamine, histamine和adrenergic receptors有亲和力。	J Cancer Res Clin Oncol, 2019, 145(6):1495-1507 Toxicol Lett, 2019, 313:77-90
S1444	Ziprasidone HCl Ziprasidone HCl (CP-88059) 是一类有效的dopamine 和 serotonin (5-HT) receptor的拮抗剂，用于精神分裂症以及双向性障碍的治疗。	Nature, 2018, 560(7718):372-376 Sci Rep, 2018, 8(1):15753 Sci Rep, 2017, 7(1):8491	a, Quantification of sterol levels in OPCs (oligodendrocyte progenitor cells) treated with the indicated molecules at 2 μM.
S6887^New	Clozapine N-oxide Clozapine N-oxide (CNO) 是一种 Clozapine (GLXC-06516) 的代谢产物，是 human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs) 的激动剂。Clozapine 是一种有效的 dopamine (DA) 拮抗剂和选择性的 muscarinic M4 receptor 的激动剂。
S0476^New	SCH-23390 hydrochloride SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride,SCH-23390 HCl) 是一种高效且选择性强的 dopamine D1-like receptor 的拮抗剂，对于D1和D5多巴胺受体亚型的Ki值分别为0.2 nM和0.3 nM。SCH-23390 hydrochloride 是一种有效的 h5-HT2C receptors 的激动剂，Ki值为9.3 nM。SCH-23390 hydrochloride 可直接抑制 G protein-coupled inwardly rectifying potassium (GIRK) channels，IC50值为268 nM。
S1280	Amisulpride Amisulpride (DAN-2163)是一种非典型的抗精神病药物，用于治疗精神病的精神分裂症和双相情感障碍的躁狂发作。
S1724	Paliperidone Paliperidone，作为 Risperidone主要的活性代谢物，是一种高效的serotonin-2A 和dopamine-2 receptor 拮抗剂，用于治疗精神分裂症。
S1920	Haloperidol Haloperidol 是一种丁酰苯类的抗精神病药。
S1771	Chlorprothixene Chlorprothixene与多巴胺和组织胺受体（如D1， D2， D3， D5， H1， 5-HT2， 5-HT6和5-HT7）具有强结合力， K_i值分别为18nM， 2.96 nM， 4.56 nM， 9 nM， 3.75 nM， 9.4 nM， 3 nM和5.6 nM。	Sci Rep, 2018, 8(1):15753
S4251	Phenothiazine Phenothiazine (ENT 38) 是多巴胺-2(D2)受体拮抗剂，因此能够降低多巴胺在大脑中的作用。
S4096	Droperidol Droperidol (NSC 169874) 在边缘系统中有效拮抗多巴胺受体亚型2(D2DR)。	Sci Rep, 2018, 8(1):15753
S3044	Lurasidone HCl Lurasidone (SM-13496)是一种非典型的抗精神病药物，抑制D2， 5-HT2A， 5-HT7， 5-HT1A和去甲肾上腺素α2C，IC50分别为1.68 nM， 2.03 nM， 0.495 nM， 6.75 nM和10.8 nM。
S2104	Levosulpiride Levosulpiride是一种选择性D2多巴胺受体拮抗剂，用作抗精神病药和促动力剂。	Sci Rep, 2018, 8(1):15753
S4086	Loxapine Succinate Loxapine Succinate是D2DR和D4DR抑制剂,5-羟色胺受体拮抗剂，也是Dibenzoxazepine类的抗精神病试剂。
S5741	Quetiapine Quetiapine 是一种非典型的抗精神病药，用于治疗精神分裂症、双相情感障碍和重度抑郁症。Quetiapine 是一种5-HT receptors 激动剂，对人 5-HT1A receptor 的pEC50值为4.77。Quetiapine 是一种 dopamine receptor 拮抗剂，对人 D2 receptor 的pIC50值为6.33。Quetiapine 对人 D2, HT1A, 5-HT2A, 5-HT2C receptor 具有中到高亲和力，pKis值为7.23、5.74、7.54、5.55。
S5559	Tetrahydropalmatine Tetrahydropalmatine (Rotundine), a plant alkaloid used as an ingredient in dietary supplement products, is a potent and selective D1 receptor antagonist.
S4731	Perphenazine Perphenazine (Trilafon, Etaperazine)是一种吩噻嗪衍生物，它是多巴胺受体阻滞剂，具有止吐和治疗精神疾病的特性。
S5153	Tetrahydroberberine Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.
S5324	Oxidopamine (hydrobromide) Oxidopamine (6-hydroxydopamine, 6-OHDA, 2,4,5-trihydroxyphenethylamine) is a neurotoxic synthetic organic compound that acts as an antagonist of the neurotransmitter dopamine with potential antineoplastic activity.
S4889	Perospirone hydrochloride Perospirone (SM-9018) is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.
S5399	Chlorprothixene hydrochloride Chlorprothixene HCl (Minithixen hydrochloride, Truxal hydrochloride, NSC 169899, NSC 56379, NSC 78193) is the hydrochloride salt form of chlorprothixene, a typical antipsychotic drug of the thioxanthene (tricyclic) class. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.
S5565	Triflupromazine hydrochloride Triflupromazine hydrochloride (Fluopromazine) is an antipsychotic medication of the phenothiazine class.	bioRxiv, 2020, 2020/9/20.4.7.30734
S4151	Penfluridol Penfluridol (TLP-607) 是一种高效的，第一代二苯丁哌啶类抗精神病药物。
S5481	Molindone hydrochloride Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist.
S2437	Rotundine Rotundine是一种选择性多巴胺D1受体拮抗剂， IC50为166 nM。	J Med Virol, 2019, 91(8):1440-1447
S4631	Prochlorperazine dimaleate salt Prochlorperazine dimaleate (Prochlorperazin, Compazine, Capazine, Stemetil)是抗精神病药物中属于吩噻嗪类的多巴胺受体D2拮抗剂。	F1000Res, 2016, 5:150
S4257	Alizapride HCl Alizapride在以外消旋混合物服用时，作为多巴胺拮抗剂促肠胃运动和止吐治疗癌症化疗引起的恶心和呕吐。
S4655	Sulpiride Sulpiride (Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil)是一种多巴胺D2受体拮抗剂。在临床治疗中，它被用作抗抑郁剂、安定药和助消化药。	Nat Commun, 2020, 11(1):941
S5714	lurasidone Lurasidone (SM-13496) is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.
S5034	Melitracen hydrochloride Melitracen hydrochloride (Thymeol)是一种潜在的dopamine D1/2 receptor拮抗剂，具有抗抑郁作用。
S1789	Tetrabenazine (Xenazine) Tetrabenazine(Nitoman, Xenazine)主要是一种可逆的、高亲和力的突触前神经元的颗粒小泡吸收单胺的抑制剂，选择性与VMAT-2结合。也能阻止dopamine D2 receptors，但亲和力相对于对VMAT-2的亲和力弱1000倍。
S6410	Clemizole Clemizole是第一代组胺受体(H1 receptor)拮抗剂，是有效的行为性和电生理癫痫活性的抑制剂。它对丙型肝炎的感染具有潜在疗效，能有效地抑制TRPC5离子通道。
S4219	Azaperone Azaperone (NSC 170976) 是一种吡啶哌嗪和丁酰苯类抗精神病药，具有镇静和止吐的效果，主要是在兽医上用作镇静剂。它是Dopamine receptors的拮抗剂，能够透过血脑屏障，结合D1和D2受体。
S6455	Clebopride (malate) Clebopride是dopamine拮抗剂，用于治疗功能性肠胃失调如恶心或呕吐。
S5428	Promazine hydrochloride Promazine (Romtiazin, Sinophenin) is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects.
S5624	Paliperidone Palmitate Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.
S5749	Chlorpromazine Chlorpromazine (CPZ) 是一种低效的典型抗精神病药，用于治疗精神病如精神分裂症。Chlorpromazine (CPZ) 在体外可抑制 5-HT(2A) receptor 和 dopamine D2。Chlorpromazine (CPZ) 还可抑制 sodium channel，并阻断HERG potassium channels，对应的IC50值为21.6 μM。	Biomaterials, 2020, 232:119701 Drug Metab Dispos, 2020, 48(8):613-621 bioRxiv, 2020, 2020/9/20.4.7.30734
S9509	Tiapride Hydrochloride Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.
S4289	Metoclopramide HCl Metoclopramide HCl是一种选择性的 dopamine D2 receptor 拮抗剂，用于治疗恶心和呕吐。
S5862	Metoclopramide Metoclopramide是一种多巴胺拮抗剂，用于治疗恶心呕吐。

目录号	产品描述	文献引用	实验数据
S0104^New	Pardoprunox (SLV-308) hydrochloride Pardoprunox (SLV-308, DU-126891, SME-308) hydrochloride (HCl) 是一种有效的部分 dopamine D2 receptor 的激动剂，对应的pEC50值为8.0，也是诱导 [³⁵S]GTPγS binding 的部分激动剂，对应的pEC50值为9.2，和 serotonin 5-HT1A receptor 的激动剂，pEC50值为6.3。
S1726	Levodopa Levodopa 是多巴胺,，肾上腺素以及去甲肾上腺素的前体，具有抗帕金森病的特性。	PLoS One, 2017, 12(3):e0173240	(A) A focused screening of Aβ generation in response to levodopa, piribedil, bromocriptine or carbidopa at indicated concentrations in SK-N-SH cells. Data are mean ± s.e.m., n = 3-4. p < 0.05; **p < 0.001 versus the control of each group.
S2451	Amantadine HCl Amantadine HCl (1-adamantanamine)用于治疗或预防某些病毒引起的呼吸道感染。	Adv Ther (Weinh), 2020, 2000034
S2011	Pramipexole 2HCl Monohydrate Pramipexole 2HCl Monohydrate 是一种部分/全部D2S， D2L， D3， D4受体激动剂，K_i为3.9， 2.2， 0.5， 5.1 nM。	Autophagy, 2016, 12(12):2374-2385
S2460	Pramipexole Pramipexole (SND 919)是部分/全部D2S， D2L， D3， D4受体激动剂，作用于D2S， D2L， D3， D4受体，K_i分别为3.9， 2.2， 0.5和5.1 nM。
S2529	Dopamine HCl Dopamine HCl 是一种广泛存在于各种动物的儿茶酚胺类神经递质，是多巴胺D1-5受体激动剂。	Cancer Commun (Lond), 2020, 10.1002/cac2.12103 Brain, 2019, 142(3):700-718
S5849	Cariprazine HCl Cariprazine (RGH-188)是一种新型二代抗精神病药物，是偏好于D3受体的dopamine D2/D3 receptor部分激动剂。
S3664	Flupenthixol dihydrochloride Flupentixol是一种抗精神病安定药物，是D1 and D2多巴胺受体的强效拮抗剂，也是α肾上腺素能受体的拮抗剂。
S3821	Nuciferine Nuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities.
S4618	Fenoldopam mesylate Fenoldopam (SKF 82526, Corlopam)是一种选择性的多巴胺受体（dopamine-1 receptor）激动剂，具有利尿特性。它可以通过小动脉的血管舒张降低血压。
S7993	SKF38393 HCl SKF38393 HCl是一种选择性dopamine D1/D5 receptor激动剂。
S4639	Brexpiprazole Brexpiprazole (OPC-34712)是一种新型的多巴胺受体D2和5-羟色胺1A受体的部分激动剂，同时也是5-羟色胺2A受体和去甲肾上腺素alpha1B、alpha2C受体的拮抗剂。其对D_2L, 5-HT_1A, 5-HT_2A, α_1B受体和 α_2C受体的Ki值分别为 0.3, 0.12, 0.47, 0.17 和 0.59 nM。
S3656	Piribedil Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
S2168	PD128907 HCl PD128907 HCl是一种有效的，选择性的多巴胺D3受体激动剂，EC50为0.64 nM，比作用于多巴胺D2受体的选择性高53倍。
S5842	Cabergoline Cabergoline (FCE-21336)是一种长效多巴胺（dopamine）激动剂和催乳激素（prolactin）抑制剂。
S4274	Rotigotine Rotigotine是一种dopamine receptor的激动剂，用于帕金森氏症和不宁腿综合征的治疗。	Cell Death Dis, 2019, 10(9):649
S5066	Pramipexole dihydrochloride Pramipexole dihydrochloride (SND919)是非麦角灵类的dopamine激动剂，用于治疗帕金森氏病和多动腿综合征，对D2S受体、D2L受体、D3和D4受体的Ki值分别为3.9 nM, 2.2 nM, 0.5 nM 和5.1 nM。

目录号	产品描述	文献引用	实验数据
S4933^New	Lithium carbonate Lithium carbonate (Li2CO3)是一种无机化合物，可治疗和预防情绪障碍，尤其是躁郁症bipolar disorder (BD)的有价值和有效的药剂。Lithium carbonate 能够改变 D2 dopamine receptors 的反应。

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S4933^New

Lithium carbonate

Lithium carbonate (Li2CO3)是一种无机化合物，可治疗和预防情绪障碍，尤其是躁郁症bipolar disorder (BD)的有价值和有效的药剂。Lithium carbonate 能够改变 D2 dopamine receptors 的反应。

目录号	产品描述	文献引用
S4732	MPTP hydrochloride MPTP HCl是一种多巴胺能的神经毒素，能在帕金森动物模型中选择性破坏多巴胺能神经元。MPTP hydrochloride可诱导凋亡。	J Neuroinflammation, 2020, 17(1):272
S8097	C-DIM12 C-DIM12是Nurr1的激活剂，刺激膀胱癌细胞和肿瘤中Nurr1所介导的细胞凋亡、抑制胶质细胞中对NF-κB依赖的基因表达。	Front Mol Neurosci, 2020, 23724 Cell Death Dis, 2018, 9(3):411
S3188	(+,-)-Octopamine HCl (+,-)-Octopamine HCl,是一种生命必需的一元胺，结构上与去甲肾上腺素相关, 在无脊椎动物中作为一种神经激素，神经调节物质以及神经递质。

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S4732