D3 receptor 选择性激动剂 | 拮抗剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S2168 PD128907 HCl

PD128907 HCl是一种有效的,选择性的多巴胺D3受体激动剂,EC50为0.64 nM,比作用于多巴胺D2受体的选择性高53倍。

Selective D3 receptor, EC50: 0.64 nM
S5066 Pramipexole dihydrochloride

Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.

Pan D3 receptor, Ki: 0.5 nM
S2460 Pramipexole

Pramipexole是部分/全部D2S, D2L, D3, D4受体激动剂,作用于D2S, D2L, D3, D4受体,Ki分别为3.9, 2.2, 0.5和5.1 nM。

Pan D3 receptor, Ki: 0.5 nM
S5842 Cabergoline

Cabergoline (FCE-21336), an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor.

Pan D3 receptor, IC50: 1.5 nM
S1771 Chlorprothixene

Chlorprothixene与多巴胺和组织胺受体(如D1, D2, D3, D5, H1, 5-HT2, 5-HT6和5-HT7)具有强结合力, Ki值分别为18nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM和5.6 nM。

Pan D3 receptor, Ki: 4.56 nM
S2437 Rotundine

Rotundine是一种选择性多巴胺D1受体拮抗剂, IC50为166 nM。

Pan D3 receptor, IC50: 3.25 μM
S3656 Piribedil

Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.

Pan
S2011 Pramipexole 2HCl Monohydrate

Pramipexole 2HCl Monohydrate 是一种部分/全部D2S, D2L, D3, D4受体激动剂,Ki为3.9, 2.2, 0.5, 5.1 nM。

Pan