天然产物
| 目录号 | 产品名 | 产品描述 |
|---|---|---|
| S6909 | Levomefolic acid | Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) 是一种天然的活性叶酸形式，在细胞水平上用于 DNA reproduction、半胱氨酸循环和同型半胱氨酸的调节等功能。 |
| S6927 | Dihydroresveratrol | Dihydroresveratrol 是一种具有显著生物活性的天然产物，一种有效的植物雌激素，是 hormone receptor 的调节剂。 |
| S3166 | Calcium 2-oxoglutarate | Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) 是2-oxoglutarate的钙盐形式。2-oxoglutarate 是自然存在于生物中的，是众所周知的在柠檬酸循环(Krebs cycle)中ATP或GTP产生的中间体。2-oxoglutarate 是 tyrosinase 的可逆抑制剂，其IC50值为15 mM。 |
| S6100 | Picrotoxin | Picrotoxin (Picrotin, Cocculin, Cocculus, NSC 403139) 是一种植物生物碱，是神经元 GABA 和 glycine receptors 的非竞争性拮抗剂。 已取得危险化学品经营许可 |
| S5910 | Alpha-Estradiol | Alpha-Estradiol (α-Estradiol, 17 alpha-Estradiol, Alfatradiol, Epiestradiol, Epiestrol, Alora, 17 α-E2) 是一种天然的、非雌性化，是生理上几乎无活性的激素17β-雌二醇（17β- E2）的立体异构体，是雌激素 estrogen 的弱抑制剂。 |
| S3761 | Eucalyptol | Eucalyptol (NSC 6171, 1,8-Cineol, 1,8-cineole, 1,8-Epoxy-p-menthane, 1,8-Oxido-p-menthane, Cineol, Cineole) 是存在于许多植物，主要是桉树种，中的单萜类油，具有抗炎和抗氧化作用。Eucalyptol 通过抗炎细胞因子的抑制作用来控制气道的粘液分泌过多和哮喘。 已取得危险化学品经营许可 |
| S5417 | Spectinomycin dihydrochloride pentahydrate | Spectinomycin dihydrochloride pentahydrate (Trobicin) 是一种广泛使用的抗生素，可通过阻止信使RNA的易位和核糖体上的转移RNA来抑制细菌蛋白质的合成。 |
| S5972 | Hydrocortisone hemisuccinate | Hydrocortisone hemisuccinate (A-hydrocort, Hydrocortisone 21-hemisuccinate) 是一种具有抗炎特性的生理性糖皮质激素，是 proinflammatory cytokine 的抑制剂，对 Interleukin-6 (IL-6) 和 IL-3 的IC50值分别为6.7 μM和21.4 μM。 |
| S9827 | Iodoacetamide | Iodoacetamide (IA, IAM, 2-Iodoacetamide) 是一种烷基化剂，通常在蛋白质组学样品制备过程中用于半胱氨酸的烷基化。 |
| S5958 | Metformin | Metformin (1,1-Dimethylbiguanide) 是一种广泛用于治疗2型糖尿病的药物，可激活肝细胞中的 AMP-activated protein kinase (AMPK)。Metformin 可促进单核细胞中的线粒体自噬。Metformin 可通过激活 JNK/p38 MAPK 途径和GADD153来诱导肺癌细胞凋亡。 |
| S5937 | DL-Carnitine | DL-Carnitine ((±)-Carnitin) 是L-Carnitine和D-Carnitine的外消旋混合物，可调节线粒体中的 fatty acid transport。DL-Carnitine 被发现对肌肉细胞和心肌无效或有毒。DL-Carnitine 可引起肌无力和心律不齐的症状。 |
| S5955 | Thiamine nitrate | Thiamine (Vitamin B1) nitrate 是一种必需的维生素，它在细胞从摄入食物中产生能量时发挥重要作用，并可增强正常的神经元活性。 |
| S5888 | Beclamide | Beclamide (N-Benzyl-3-chloropropionamide, beta-chlorpropionamide) 具有镇静和抗惊厥作用。 |
| S5199 | Oxytetracycline hydrochloride | Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride 是一种抗生素，会干扰细菌产生必需蛋白质的能力。 |
| S4486 | Thiamine monochloride | Thiamine (Vitamin B1) monochloride 是一种必不可少的维生素 vitamin，它在摄取食物的细胞能量生产中起着重要作用，并能增强正常的神经元活性。 |
| S4495 | Quinine | Quinine 是一种来自cinchona tree的生物碱，是一种抗疟疾剂和钾通道 potassium channel 的抑制剂，可抑制电压诱发的mSlo3 (KCa 5.1)通道电流，脉冲至+100 mV，其IC50值为169 μM。 |
| S4490 | Tetracycline | Tetracycline (TC) 是一种广谱的抗生素，对多种微生物具有活性，包括革兰氏阳性和革兰氏阴性细菌、衣原体、支原体、立克次氏体和原生动物寄生虫。 |
| S3590 | Triolein | Triolein 是一种 metalloproteinase-1 (MMP-1) 的抑制剂，可降低辐射角化细胞中 IL-6 和 ROS 的表达。 |
| S4713 | Atropine | Atropine (Atropen, Atnaa, Tropine tropate, DL-Hyoscyamine) 是一种具有竞争性的 muscarinic acetylcholine receptor (mAChR) 的拮抗剂，具有抗近视作用。 |
| S5193 | L-Thyroxine sodium salt pentahydrate | L-Thyroxine (Levothyroxine, L-T4) sodium salt pentahydrate 是一种合成的T4激素，可用于平衡甲状腺功能减退症。 |
| S5260 | ATP | ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) 是一种多功能的三磷酸核苷，是免疫和炎症反应中重要的内源性信号分子。 |
| S5790 | Folinic acid | Folinic acid (Leucovorin) 是一种生物叶酸，可增加组织中叶酸还原的水平，从而促进对 thymidylate synthase (TS) 的抑制。 |
| S6466 | Eicosapentaenoic acid ethyl ester | Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) 是omega-3 fatty acid 药剂，可显著地降低 triglyceride (TG) 的水平并改善其他脂质参数而不会显着增加低密度脂蛋白(LDL)胆固醇的水平。 |
| S4979 | Procaine penicillin G | Penicillin G Procaine (PGP, Penicillin G Procaine, Bicillin C-R) 是一种将青霉素G与Procaine相结合的结晶复合物，一种β-内酰胺抗生素。 |
| S5922 | L-Carnitine hydrochloride | L-Carnitine ((R)-Carnitine, Levocarnitine) hydrochloride 可改善氧饱和度，并抑制 leukotriene 的合成。L-Carnitine hydrochloride 的功能是将长链脂肪酰基辅酶A转运到线粒体中，以通过β氧化降解。 |
| S0911 | Hypaphorine | Hypaphorine 大量存在于王不留行vaccaria semen中，通过抑制 ERK 或/和NFκB信号通路来抵消炎症。 |
| S4857 | L-Ornithine | L-ornithine ((S)-2,5-Diaminopentanoic acid) 通过增加能量消耗的效率及促进氨的排泄而具有抗疲劳的作用。它是尿素循环中的关键反应物之一。 |
| S3578 | Pyrroloquinoline quinone | Pyrroloquinoline quinone (PQQ, Methoxatin) 是一种天然的抗氧化剂，具有抗氧化和抗衰老的作用。Pyrroloquinoline quinone 可预防雌激素缺乏引起的骨质疏松症。 |
| S4496 | Maltose monohydrate | Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose) monohydrate 是一种非必需营养素，可提供能量，是糖原和淀粉在肠内消化的中间产物，存在于发芽的谷物以及其他植物和蔬菜中。 |
| S9631 | Puromycin aminonucleoside | Puromycin aminonucleoside (NSC 3056, PAN, Stylomycin aminonucleoside, ARDMA, SAN) 是抗生素puromycin的氨基核苷部分，是 dipeptidyl-peptidase II 和 cytosol alanyl aminopeptidase 的可逆抑制剂，会在系膜细胞(MCs)中诱导凋亡，并伴有细胞活力下降和炎症反应增强。 |
| S7428 | Rocaglamide | Rocaglamide (Roc-A) 是从Aglaia物种中分离出来的一种有效的 heat shock factor 1 (HSF1) 活化的抑制剂，对HSF1的IC50值约为50 nM。Rocaglamide 可抑制翻译起始因子 eIF4A 的功能。Rocaglamide 还抑制 NF-κB 的活性。Rocaglamide 具有抗肿瘤活性。 |
| S3569 | Spermidine | Spermidine 是一种天然的多胺，可刺激细胞保护性 macroautophagy/autophagy。 |
| S4438 | Benzophenone | Benzophenone (Diphenyl ketone, Benzoylbenzene) 可滤除UVA和UVB射线，广泛用于各种防晒霜和个人护理产品中。 |
| S4440 | 2-Phenylacetamide | 2-Phenylacetamide 是从具有雌激素活性的 Lepidium apetalum Willd (LA) 的种子中分离出的主要化合物，可在子宫和MCF-7细胞中增加 Estrogen receptorα (ERα)、ERβ 和 GPR30 的表达。 |
| S4425 | Rifamycin S | Rifamycin S 是一种quinone和抗 Gram-positive bacteria(包括MRSA) 的抗生素，是一种用于治疗肺结核和麻风病的临床药物。Rifamycin S 可产生 reactive oxygen species (ROS)，并抑制微粒体脂质过氧化 microsomal lipid peroxidation。 |
| S4436 | Pleuromutilin | Pleuromutilin (Drosophilin B, Mutilin 14-glycolate) 是新型抗生素的先导化合物，它通过结合细菌的50S核糖体亚基来抑制细菌蛋白质的合成。 |
| S4494 | Methionine | Methionine (MRX-1024, D-Methionine) 是 GABAA receptor 的激活剂，可调节神经元活性。 |
| S3588 | Hexylene glycol | Hexylene glycol (HG, 2-Methyl-2,4-pentanediol, MPD) 是一种衍生自丙酮的氧化溶剂，已广泛用于工业化学品和化妆品中。Hexylene glycol 具有抗菌 antibacterial 和抗真菌 antifungal 的特性。 |
| S3595 | D-Gluconic acid | D-Gluconic acid 是一种抗真菌 antifungal 药。 |
| S6446 | Sodium citrate dihydrate | Sodium citrate dehydrate (Trisodium citrate dihydrate, Citric acid trisodium salt dihydrate) 是一种首选的抗凝血剂。 |
| S3594 | Adipic acid | Adipic acid (Hexanedioic acid) 是一种重要的二羧酸，可用于制造尼龙和聚氨酯塑料。 |
| S3596 | Polyvinylpyrrolidone | Polyvinylpyrrolidone (PVP, Polyvidone, Povidone) 是一种惰性的、水溶性的、无毒的、耐温且pH稳定的、具有生物相容性的、可生物降解的聚合物，有助于封装和满足亲水性和亲脂性药物的需求。Polyvinylpyrrolidone 已被广泛测试并用作有效的伤口愈合促进剂。 |
| S3598 | Sucrose | Sucrose (D-(+)-Saccharose) 是植物天然产生的一种常见糖，是一种二糖，由两个单糖：葡萄糖和果糖组成的分子。 |
| S4424 | Hyaluronidase | Hyaluronidase (Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase, Amphadase, Hydase, Vitrase) 是一种天然酶，可降解透明质酸，而透明质酸是细胞外基质的重要组成部分。 |
| S0235 | Lavendustin B | Lavendustin B 抑制 HIV-1 integrase (IN) 与其同源的细胞辅助因子 lens epithelium-derived growth factor (LEDGF/p75) 的相互作用。Lavendustin B 是 Tyrosine Kinase 的抑制剂，也是 glucose transporter 1 (Glut1) 的竞争性抑制剂。 |
| S9794 | Melittin | Melittin (MLT, Forapin, Forapine) 是 phospholipase A2 (PLA2) 的活化剂，可刺激低分子量PLA2的活性，但不会增加高分子量酶的活性。 |
| S3168 | cis-Resveratrol | cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) 是Resveratrol的顺式异构体。Resveratrol 是一种天然的酚类化合物，具有抗氧化、抗炎、保护心脏和抗癌的特性。Resveratrol 是 pregnane X receptor (PXR) 的抑制剂，也是 Nrf2 和 SIRT1 的激活剂，并可能诱导凋亡。Resveratrol 还可抑制多种靶标，包括 5-lipoxygenase (LOX)、cyclooxygenase (COX)、IKKβ、DNA polymerases α和δ，IC50分别为2.7 μM、<1 μM、1 μM、3.3 μM和5 μM。 |
| S3499 | Monocaprylin | Monocaprylin (2,3-dihydroxypropyl octanoate, Monoctanoin, 1-Octanoyl-rac-glycerol, MC) 对金黄色葡萄球菌和大肠杆菌具有优异的抗菌活性。 |
| S0921 | Wilforine | Wilforine (WR) 是在wilfordii植株中发现的倍半萜吡啶生物碱，可显著地抑制 P-glycoprotein (P-gp) 的外排活性。 |
| S3351 | Sodium phenylpyruvate | Sodium phenylpyruvate (Phenylpyruvic acid sodium salt) 可抑制氨基酸形成 amino acid formation 并降低氧气消耗。 |
| S2995 | 4-Hydroxyphenylpyruvic acid | 4-Hydroxyphenylpyruvic acid (4-HPPA) 是一种丰富的多酚结肠代谢产物，是一种有效的清除剂，可抑制 free radicals 和 cyclooxygenase-2 (COX-2) 的水平，并有助于降低结肠癌发展的风险。 |
| S6918 | Oleandrin (PBI-05204) | Oleandrin (PBI-05204, Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol) 是 Na+/K+-ATPase 的抑制剂，IC50值为0.62 μM。Oleandrin 可诱导凋亡并减少人胶质瘤细胞的体外迁移。 |
| S6990 | Phytohemagglutinin | Phytohemagglutinin (PHA, Phaseolus vulgaris agglutinin) 在毕赤酵母中利用天然信号肽或酿酒酵母α-因子前体序列表达，将蛋白质引导至分泌途径。Phytohemagglutinin 可通过增加凋亡蛋白 Bax 和激活 caspases-3 来诱导人HEp-2癌细胞的凋亡。 |
| P1201 | LL37 (Human cathelicidin) | LL37 (Human cathelicidin, Ropocamptide) 是与Cathelicidin相关的 antimicrobial 抗菌肽，具有强大的趋化和免疫调节特性。 |
| S3069 | Deoxycholic acid sodium salt | Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) 会特定地激活刺激棕色脂肪组织(BAT)的 TGR5 receptor (GPCR19) 的产热活动。 |
| S3248 | 2'-Deoxyadenosine 5'-monophosphate | 2'-Deoxyadenosine 5'-monophosphate (5'-dAMP) 是一种内源性代谢产物，仅在酸性条件下被光敏降解。 |
| S3268 | 2'-Deoxycytidine 5'-monophosphate | 2'-Deoxycytidine-5'-monophosphoric acid (dCMP) 是一种内源性代谢产物，可以用作描述由二次电子诱导的DNA链断裂机理的模型，并且主要通过C-O磷酸酯键的解离而分解。 |
| S3318 | N-Acetyl-L-arginine dihydrate | N-Acetyl-L-arginine (Ac-Arg-OH) dihydrate 是一种内源性代谢产物。 |
| S3319 | Levoglucosan | Levoglucosan (LG, LEV, Leucoglucosan, Glucosan, 1,6-anhydro-b-D-Glucose) 是一种内源性代谢产物。 |
| S3324 | Sodium 2-(1H-indol-3-yl)acetate | Sodium 2-(1H-indol-3-yl)acetate (3-Indoleacetic acid sodium, Indole-3-acetic acid sodium, 3-IAA sodium) 是一种内源性代谢产物。 |
| S3326 | Phytic acid dipotassium salt | Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)) 是一种稻谷提取物和消化物中的内源性代谢物，可抑制 β-secretase 1 (BACE1)，其IC50值约为0.25 μM。 |
| S3331 | 2-Aminoethylphosphonic acid | 2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) 是一种丰富而普遍存在的天然膦酸酯，被许多原核谱系用作磷源。 |
| S3335 | Phospho(enol)pyruvic acid monopotassium salt | Phospho(enol)pyruvic acid monopotassium salt (Potassium 1-carboxyvinyl hydrogenphosphate) 是一种内源性代谢产物。 |
| S3343 | Methyl β-D-Galactopyranoside | Methyl β-D-Galactopyranoside (Methyl beta-D-galactoside, Methylgalactoside) 是一种内源性代谢物。 |
| S3370 | 3-Methoxytyramine hydrochloride | 3-Methoxytyramine (3-O-methyl Dopamine, 3MT) hydrochloride 是多巴胺的主要细胞外代谢产物，是一种神经调节剂，在某些情况下可能参与运动控制。 |
| S3310 | D-(+)-Galacturonic acid monohydrate | D-(+)-Galacturonic acid monohydrate (D-Galacturonic acid hydrate, d-GalA, D-galUA) 是一种内源性代谢产物，可用于工程酿酒酵母中。 |
| S3323 | 2-Hydroxycaproic acid | 2-Hydroxyhexanoic acid (2-Hydroxyhexanoic acid) 是一种内源性代谢产物。 |
| S2997 | DL-Tartaric acid | DL-Tartaric Acid (2,3-Dihydroxysuccinic acid) 是一种白色结晶有机酸，可从许多植物中，特别是罗望子树tamarinds和葡萄grapes中分离出来，并用作抗氧化剂和添加剂，以赋予酸味。 |
| S3087 | N-Acetyl-DL-methionine | N-Acetyl-DL-methionine 是一种活性内源性代谢产物，可降低雄性Bom:NMRI mice的肝脏 glutathione 水平。 |
| S3092 | Glyoxylic acid monohydrate | Glyoxylic acid monohydrate (2,2-Dihydroxyacetic acid) 是一种与大气有关的酮酸。 |
| S3093 | Pyrazole | Pyrazole (1H-pyrazole) 是具有两个氮原子的五元杂芳族环，具有重要意义。Pyrazole 是设计和开发新药理学必不可少的支柱。 |
| S3094 | N-Acetyl-L-alanine | N-Acetyl-L-alanine (NAAL, Ac-Ala-OH) 是一种活性内源性代谢产物。 |
| S3157 | 3-Hydroxybenzaldehyde | 3-Hydroxybenzaldehyde (3-HBA) 是自然界中常见的一种苯甲醛，由 3-hydroxybenzyl-alcohol 脱氢酶产生，并且是大鼠和人体中醛脱氢酶(ALDH)的底物。3-Hydroxybenzaldehyde 具有血管保护作用。 |
| S3315 | 6-Hydroxyindole | 6-Hydroxyindole (1H-indol-6-ol) 是一种内源性的有效且持久的 OATP1B1 的抑制剂，其IC50值约为10 μM。 |
| S3334 | Glycolaldehyde dimer |
Glycolaldehyde dimer (2,5-Dihydroxy-1,4-dioxane, 1,4-Dioxane-2,5-diol, DD) is an active endogenous metabolite that appears moderate absorbent and fluorescent, when it reacts with glycine (Gly)/ammonium sulfate (AS). |
| S3336 | Heptadecanoic acid | Heptadecanoic acid (C17:0) 是一种奇数链饱和脂肪酸，可显著地抑制细胞增殖和迁移，同时促进PC-9和PC‑9/GR细胞的凋亡。Heptadecanoic acid 与多种疾病相关，包括冠心病，前驱糖尿病和2型糖尿病以及多发性硬化症的发生率。 |
| S3337 | L-Histidinol dihydrochloride | L-Histidinol dihydrochloride 是必需氨基酸L-组氨酸的结构类似物，是一种 protein biosynthesis 的可逆抑制剂，它引起培养中非致瘤和致瘤细胞的不同反应。 |
| S3338 | D-(-)-Lyxose | D-(-)-Lyxose (D-Lyxose) 是一种活性内源性代谢产物。 |
| S3345 | Nα-Acetyl-L-lysine | Nα-Acetyl-L-lysine (Ac-Lys-OH, N(alpha)-Acetyllysine) 是一种活性内源性代谢物。 |
| S3347 | 3-Methylglutaric acid | 3-Methylglutaric acid (MGA, 3MG acid) 是一种明显的C6二羧酸有机酸，可以用作单一的固态NMR标准化合物来执行除磁体匀场之外的所有校准步骤。 |
| S3348 | O-Acetyl-L-serine hydrochloride | O-Acetyl-L-serine (OAS, O-Acetylserine, O-Acetyl-L-serine) hydrochloride (HCl) 是一种细菌和植物中氨基酸半胱氨酸生物合成的中间体，其显示出一种信号功能，不论植物的硫状态如何，它都能改变特定基因的转录水平。 |
| S3358 | 4-Acetamidobutyric acid | 4-Acetamidobutanoic acid (N-acetyl GABA) 是一种 Gamma-aminobutyric acid (GABA) 的衍生物，由GABA氮原子的单乙酰化产生。 |
| S3360 | Bis(2-ethylhexyl) phthalate | Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) 可诱导幼虫斑马鱼 Danio rerio 中的 DNA strand breaks 和基因表达改变。 |
| S3095 | Itaconic acid | Itaconic acid 是一种巨噬细胞特异性 (Mϕ-specific) 代谢产物，可介导巨噬细胞代谢与腹膜肿瘤之间的交互作用。Itaconic acid 还是聚合物，化学品和燃料的前体，可以由许多真菌合成。 |
| S3096 | L-Histidine monohydrochloride monohydrate | L-Histidine monohydrochloride monohydrate (L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O) 是必需氨基酸L-组氨酸的结构类似物，是 protein biosynthesis 的可逆抑制剂，可引起培养中非致瘤细胞和致瘤细胞的不同反应。 |
| S3098 | N-Acetylglycine | N-Acetylglycine (NAGly, Aceturic acid, Acetamidoacetic acid) 是许多食品的次要成分，没有遗传毒性或急性毒性。 |
| S3097 | 5,6-Dimethylbenzimidazole | 5,6-Dimethylbenzimidazole (5,6-DMB, Dimezol, Dimedazol, 5,6-Dimethyl-1H-benzo[d]imidazole, 5,6-Dimethyl-1H-benzimidazole) 是一种维生素B12的前体。 |
| S3107 | D-Pyroglutamic acid | D-Pyroglutamic acid (D-5-Oxoproline, D-Pyr-OH, 5-oxo-D-proline, (R)-5-Oxopyrrolidine-2-carboxylic acid) 是一种有效的内源性代谢产物，可对抗由N-methyl-D-aspartate receptor拮抗剂 AP-5 诱导的被动回避行为的中断。 |
| S3109 | N-Acetyl-L-leucine | N-acetyl-L-leucine 是一种有效的内源性代谢产物，通过在小脑和丘脑中起作用，加速单侧迷路切除后前庭代偿。 |
| S3111 | Pyridoxal hydrochloride | Pyridoxal hydrochloride (HQ) 是一种活性内源性代谢产物。 |
| S3365 | (S)-(-)-1-Phenylethanol | (S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) 是一种具有风味特性的1-Phenylethanol的对映异构体。 |
| S3366 | Monoethyl malonic acid | Monoethyl malonic acid (Ethyl hydrogen malonate, Monoethyl malonate, 3-Ethoxy-3-oxopropanoic acid) 是 ethyl 3-ethoxypropionate (EEP) 的主要尿代谢产物。 |
| S3320 | (R)-3-Hydroxybutanoic acid | (R)-3-Hydroxybutanoic acid (R-3HB, D-3-hydroxybutyric acid) 是PHB (poly[(R)-3-hydroxybutyrate])的单体，具有广泛的工业和医学应用。(R)-3-Hydroxybutanoic acid 也可以用作合成纯的可生物降解的PHB及其共聚酯的手性前体。 |
| S3049 | Calcium 2-hydroxy-4-(methylthio)butanoate | Calcium 2-hydroxy-4-(methylthio)butanoate 是一种活性内源性代谢物。 |
| S3135 | 2-Amino-1-phenylethanol | 2-Amino-1-phenylethanol (2-APE) 是一种去甲肾上腺素类似物。 |
| S3221 | Thymidine 5'-monophosphate disodium salt | Thymidine-5'-monophosphate (5'-Thymidylic acid) disodium salt 是一种活性内源性代谢物。 |
| S3311 | Myosmine | Myosmine 是次要的烟草生物碱之一，并存在于各种食品中。Myosmine 对 a4b2 nicotinic acetylcholinergic receptors (nAChR) 具有低亲和力，Ki为3300 nM。 |
| S3321 | N-Methylnicotinamide | N-Methylnicotinamide (MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide) 是一种活性内源性代谢产物，可通过调节ADMA-DDAH轴改善内皮功能障碍并减轻动脉粥样硬化。 |
| S3325 | L-Cysteic acid monohydrate | L-Cysteic acid monohydrate (CAM) 是一种活性内源性代谢物。 |
| S3329 | (L)-Dehydroascorbic acid | (L)-Dehydroascorbic acid (DHA) 是一种l-Ascorbic acid (AsA)的氧化形式，其在硫醇的存在下可有效地清除非热等离子体诱导的羟基自由基，而自身不能清除羟基自由基。 |
| S3342 | Petroselinic acid | Petroselinic acid (PSA) 是一种从香菜果实的植物油中分离出来的油酸的位置异构体。Petroselinic acid 可用于新槐糖脂的发酵。 |
| S3344 | Serotonin creatinine sulfate monohydrate | Serotonin (5-Hydroxytryptamine) creatinine sulfate monohydrate 是一种活性内源性代谢产物。 |
| S3346 | 1-Methylnicotinamide chloride | 1-Methylnicotinamide (1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium, Trigonellamide) chloride 是烟酰胺的活性内源性代谢产物，具有抗炎和抗血栓形成的作用。1-Methylnicotinamide 可增强肿瘤血管的形成，并显著地增加 prostacyclin (PGI2) 的生成。 |
| S3349 | Phosphocholine chloride calcium salt tetrahydrate | Phosphocholine (Phosphorylcholine) chloride calcium salt tetrahydrate 是一种活性内源性代谢物。 |
| S3350 | Cholesteryl linoleate | Cholesteryl linoleate 是一种人鼻液中极性较低的脂质，助力固有的抗菌活性。 |
| S3352 | Tricosanoic acid | Tricosanoic acid 是一种脂族羧酸，具有很强的生发作用。 |
| S3353 | Lithium acetoacetate | Lithium acetoacetate (LiAcAc, Acetoacetic acid lithium salt, Lithium 3-oxobutanoate) 是一种活性内源性代谢产物，可影响细胞系的生长。Lithium acetoacetate 可用作乙酰乙酸盐标准品，用于测量生物样品中的乙酰乙酸。 |
| S3354 | DL-2,3-Diaminopropionic acid monohydrochloride | DL-2,3-Diaminopropionic acid monohydrochloride (2,3-Diaminopropanoic acid hydrochloride) 是一种活性内源性代谢物。 |
| S3355 | 3-Hydroxyanthranilic acid | 3-Hydroxyanthranilic Acid (3-HAA, 3-HANA)是一种色氨酸代谢物具有免疫调节作用，可能是通过抑制 PI3K/Akt/mTOR 和 NF-κB 活性，减少促炎性介质的产生。 |
| S3356 | Phosphonoacetic acid | Phosphonoacetic acid (PAA) 是一种活性内源性代谢产物，具有限制 DNA biosynthesis 的潜力。Phosphonoacetic acid 具有抗病毒的活性。 |
| S3357 | Elaidic acid | Elaidic acid 是一种主要的反式脂肪酸，可抑制细胞活力，并通过增强氧化应激 oxidative stress 来促进细胞的凋亡。Elaidic acid 可用作药物溶剂。 |
| S3359 | Isomaltulose hydrate | Isomaltulose (Palatinose) hydrate 是一种 disaccharide carbohydrate，广泛应用于在运动期间维持血糖和水合作用。 |
| S3361 | (3-Carboxypropyl)trimethylammonium chloride | (3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine, γBB hydrochloride) 是小鼠饮食中L-carnitine被肠道微生物分解的中间代谢产物。 |
| S3362 | D-Gulonic acid γ-lactone | D-Gulonic acid γ-lactone (Gulonolactone, D-Gulono-1,4-lactone, 1,4-D-Gulonolactone) 是一种活性内源性代谢物。 |
| S3363 | DL-Mandelic acid | DL-Mandelic acid (MA, 2-Hydroxy-2-phenylacetic acid, Amygdalic acid, Almond acid) 可通过阴离子交换反应嵌入到Zn-Al层状双氢氧化物(LDH)中，从而构建新型的抗菌分层材料。 |
| S3367 | cis-4-Hydroxy-D-proline | cis-4-Hydroxy-D-proline (H-D-cis-Hyp-OH) 是一种内源性代谢产物，可用于研究D-丙氨酸脱氢酶的特异性和动力学。 |
| S3368 | Uridine-5'-diphosphate disodium salt | Uridine-5'-diphosphate (UDP) disodium salt 是一种有效的、选择性的 P2Y6 receptor 的天然激动剂，其EC50值为300 nM，pEC50值为 6.52。Uridine-5'-diphosphate (UDP) disodium salt 也是 P2Y14 receptor 的拮抗剂，pEC50值为 7.28。 |
| S3371 | N-Acetyl-D-mannosamine | N-Acetyl-D-mannosamine (ManNAc, N-acetyl-beta-mannosamine) 是唾液酸的前体，可改善年龄相关的突触传递和长期增强(LTP)的衰减。N-Acetyl-D-mannosamine 的治疗是认知功能障碍的潜在治疗应用。 |
| S3088 | (±)-Methyl Jasmonate | (±)-Methyl Jasmonate (MeJA, Methyl jasmonate, Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate)，是一种植物激素，在植物中起着至关重要的细胞调节剂的作用，是调节炎症性肠病(IBDs)的新候选药物，可调节 caspase 型蛋白酶家族主要类型的表达。 |
| S3169 | 2'-Deoxyuridine 5'-monophosphate disodium salt | 2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) 是胸苷酸合酶的底物，并可被转化为deoxythymidine monophosphate (dTMP)。在甲基化步骤中，dUMP对dTMP的抑制作用是控制细菌和真核细胞生长的关键。 |
| S3322 | Nicotinuric acid | Nicotinuric acid (NUA) 是烟酸的主要排毒产物，可以作为烟酸在肝脏生物转化中的简单定量指标。 |
| S3332 | D-Mannosamine hydrochloride | D-Mannosamine hydrochloride ((2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride) 是一种活性的内源性代谢产物。 |
| S3364 | 3-Hydroxyphenylacetic acid | 3-Hydroxyphenylacetic acid (3-HPAA) 是一种酚酸，主要存在于橄榄油废水中，也是膳食类黄酮槲皮素flavonoid quercetin的肠道代谢产物。3-Hydroxyphenylacetic acid 具有抗菌性能。 |
| S3040 | Isocitric acid trisodium salt | Isocitric acid (DL-Isocitric acid) trisodium salt 是一种活性的内源性代谢产物。 |
| S3089 | 12-Hydroxydodecanoic acid | 12-Hydroxydodecanoic acid (G12) 是一种活性内源性代谢产物。 |
| S3341 | Palmitoleic acid | Palmitoleic acid (POA, Palmitoleate) 可通过依赖于PPARα的 AMPK 和 FGF-21 活化来刺激肝脏中葡萄糖的摄取。 |
| S2989 | Nα-Acetyl-L-asparagine | Nα-Acetyl-L-asparagine (N-Acetylasparagine, (S)-2-acetamido-4-amino-4-oxobutanoic acid) 是一种存在于人脑中的内源性代谢产物。 |
| S2991 | Thiamine monophosphate chloride dihydrate | Thiamine monophosphate chloride dihydrate (Vitamin B1 Monophosphate Chloride, Sineurina, Phosphothiamine) 是一种内源性代谢物。 |
| S2992 | Sodium mesoxalate monohydrate | Sodium mesoxalate monohydrate (sodium 2,2-dihydroxymalonate) 是一种内源性代谢产物。 |
| S2993 | D-Saccharic acid potassium salt | D-Saccharic acid potassium salt (D-Glucaric acid potassium, Potassium bisaccharate) 是一种内源性代谢产物。 |
| S2999 | Acetic acid octyl ester | Acetic acid octyl ester (Octyl acetate) 是野生 parsnip (Pastinaca sativa) 的外壳或油管中精油的主要成分之一。Acetic acid octyl ester 具有抗氧化活性。 |
| S3006 | Methyl isoeugenol | Methyl isoeugenol (Methylisoeugenol) 是从 Acori Tatarinowii Rhizoma 分离得到的丁香酚类似物异丁香酚。Methyl isoeugenol 是一种对Z. diversus极具吸引力的诱剂，可作为监控和雄性灭计划中的引诱剂。 |
| S3009 | Menthone | Menthone 是薄荷精油(Mentha piperita L.)的主要挥发性成分之一。Menthone 可用作抗氧化剂，具有良好的补偿作用，可显着减少精子细胞中的 DNA damages。 |
| S3091 | Methyl acetoacetate | Methyl acetylacetate (MAA, Acetoacetate methyl ester, Methyl 3-oxobutanoate, Methyl 3-oxobutyrate, Methyl acetoacetate, Methyl acetylacetate) 是一种内源性代谢产物，可用作合成药物的化学试剂。 |
| S2998 | Isophorone | Isophorone (IPHO) 是一种α,β-不饱和环状酮，是一种透明的液体，带有樟脑样的气味。Isophorone 可用作聚合物的前体。 |
| S3313 | Nudifloric Acid | Nudifloric acid (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid)，是从一种抗氧化、抗癌、抗炎、抗糖尿病、抗肥胖、抗血管生成和抗伤害感受活动飞虫草 Cordyceps bassiana 中分离出来的。 |
| S3317 | cis-3-Hexenyl hexanoate | Cis-3-Hexenyl hexanoate ((Z)-3-hexenyl hexanoate) 是一种植物挥发物，可将热带和果肉风味与柑橘和绿色细腻感带入各种水果风味。 |
| S3327 | Disodium 5'-inosinate monohydrate | Disodium 5'-inosinate monohydrate (Inosine 5'-monophosphate disodium salt hydrate) 是一种内源性代谢物。 |
| S3333 | (2R,3R)-(-)-2,3-Butanediol | (2R,3R)-(-)-2,3-Butanediol ((2R,3R)-Butane-2,3-diol) 是内源性代谢产物。 |
| S2990 | Dihydroxyfumaric acid hydrate | Dihydroxyfumaric acid hydrate (DHF) 是一种内源性代谢物。Dihydroxyfumaric acid hydrate (DHF) 的二酯衍生物已专门用作有机合成中的亲电子试剂。 |
| S2988 | DL-5-Hydroxylysine hydrochloride | DL-5-Hydroxylysine hydrochloride 是一种内源性代谢产物，是5-羟基赖氨酸D-和L-对映体的外消旋混合物，可用作自由基诱导的蛋白质氧化的潜在靶标。 |
| S2994 | DL-Homocysteine | DL-Homocysteine 是一种弱神经毒素，会影响脑中 kynurenic acid (KYNA) 的产生。DL-Homocysteine 可抑制KYNA生物合成酶、kynurenine aminotransferases (KATs) I和II的活性。 |
| S3099 | δ-Valerolactone | δ-Valerolactone (Tetrahydro-2H-pyran-2-one, 5-Valerolactone, oxan-2-one) 是一种内源性代谢物。 |
| S3328 | N-Formyl-L-methionine | N-Formyl-L-methionine (For-Met-OH) 是一种内源性代谢产物。 |
| S6955 | Insulin (human) | Insulin (human) (Insulin regular) 是一种调节葡萄糖水平的多肽激素。Insulin 通常用于治疗糖尿病患者的高血糖症。效价(potency)：29 units/mg。 |
| S2986 | 9-Methoxycanthin-6-one | 9-Methoxycanthin-6-one 是存在于完整的植物部分和不同外植体的愈伤组织中的具有抗肿瘤活性的成分。 |
| S3108 | 2,5-Dimethylpyrazine | 2,5-Dimethylpyrazine (NSC 49139) 是一种内源性代谢产物。 |
| S2996 | L-DAB HBR | L-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) 是一种 GABA (Gamma-aminobutyric acid) transaminase 的抑制剂，IC50值大于500 μM。L-DAB HBR 表现出抗肿瘤活性。 |
| S3029 | Malonic acid | Malonic acid (MOA) 是气溶胶中的主要dicarboxylic acids (DCAs)之一，通过实验和计算得出，它是一种强酸。Malonic acid (MOA) 可充当形成基于SA-A的纯簇的中介桥。 |
| S3086 | Maleic acid | Maleic acid 可抑制 glutamate decarboxylase (GAD) 的活性，从而增强 Listeria monocytogenes 的酸敏感性。Maleic acid 会影响细胞外 GABA 的水平。 |
| S3090 | trans-Aconitic acid | trans-Aconitic acid (TAA) 是Echinodorus grandiflorus（一种在巴西用于治疗类风湿性关节炎的药用植物）的叶子中的丰富成分。 |
| S3101 | 2-Deoxy-D-ribose | 2-Deoxy-D-ribose (Thyminose, Deoxyribose) 是一种内源性代谢产物。 |
| S3118 | L-Homoserine | L-Homoserine (L-Hse) 是苏氨酸，蛋氨酸和赖氨酸的重要生物合成中间体。 |
| S3123 | 3-Methyl-2-buten-1-ol | 3-Methyl-2-buten-1-ol (Prenol, Prenyl alcohol, Dimethylallyl alcohol) 是一种内源性代谢产物。 |
| S3143 | Pyruvic acid | Pyruvic acid (Acetylformic acid) 是一种重要的有机化学中间体，在心肌细胞的病理生理和治疗中发挥作用。Pyruvic acid 可显着提高 lactate dehydrogenase (LDH) 和 creatine kinase (CK) 的水平，并降低 Ca2+Mg2+-ATPase 和 Na+K+-ATPase 的水平。 |
| S3084 | Guanosine 5'-triphosphate trisodium salt | Guanosine 5'-triphosphate (5'-GTP, Guanosine triphosphate, H4GTP) trisodium salt 是鼠细胞中成肌细胞分化的增强剂。Guanosine 5'-triphosphate trisodium salt 可上调miRNA（特别是miR133a和miR133b）和肌原性调节因子，并诱导人肌原性前体细胞在细胞外环境中释放出被鸟苷基分子（主要是鸟苷）填充的外泌体。 |
| S3125 | N-Formylglycine | N-Formylglycine (2-formamidoacetic acid, For-Gly-OH, FGly) 是一种内源性代谢产物。 |
| S3126 | Sodium 2-hydroxybutanoate | Sodium 2-hydroxybutanoate (Sodium 2-hydroxybutyrate, Sodium DL-2-hydroxybutyrate)是由2-氨基丁酸转化而成的一种中间代谢物。 |
| S3127 | 2,4-Dihydroxypyrimidine-5-carboxylic acid | 2,4-Dihydroxypyrimidine-5-carboxylic Acid (Uracil 5-carboxylic acid, Isoorotic acid, 5-Carboxyuracil) 是一种内源性代谢产物。 |
| S3128 | N-Acetyl-D-galactosamine | N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) 是一种内源性代谢物。 |
| S3131 | L-(-)-Glucose | L-Glucose (L-(-)-Glucose) 是D-葡萄糖的对映异构体。L-Glucose 可促进食物摄取，而细胞不能将其用作能量来源，因为它不能被己糖激酶磷酸化。 |
| S3134 | D-(-)-Tartaric acid | D-(-)-Tartaric acid 是酒石酸的非天然异构体，它是具有广泛的工业和科学应用的重要手性化学构件。 |
| S3141 | Maleimide | Maleimide 显示出荧光猝灭能力，并且可以作为荧光探针用于硫醇分析物的特异性检测。Maleimide 还用于生产抗体偶联药物(ADC)，用于癌症研究。 |
| S3142 | Potassium sorbate | Potassium sorbate (Sorbic acid potassium) 是一种无毒的食品防腐剂，它是从 Sorbus aucuparia 中分离出来的。Potassium sorbate 是大多数霉菌，酵母菌和某些细菌的有效抑制剂。 |
| S3145 | Pimelic acid | Pimelic acid (Heptanedioic acid, 1,5-Pentanedicarboxylic acid, 1,7-Heptanedioic acid) 是源自脂肪酸合成途径的枯草芽孢杆菌中生物素的前体。 |
| S3152 | Glutaric acid | Glutaric acid (GA) 是一种有吸引力的C5二羧酸，在生物化学工业中具有广泛的应用。 |
| S3159 | Citraconic acid | Citraconic acid (CA) 是一种存在于野生大豆中的甲基支链脂肪酸。 |
| S3316 | 5-Hydroxy-1-tetralone | 5-hydroxy-1-tetralone 是一种荧光标记 fluorescent labeling 的试剂，用于从少量生物样品中测定糖鞘脂。 |
| S3330 | Maleamic acid | Maleamic acid ((Z)-4-Amino-4-oxobut-2-enoic acid) 是一种内源性代谢产物。 |
| S3339 | 3-(2-Hydroxyphenyl)propionic acid | 3-(2-Hydroxyphenyl)propanoic acid (Melilotic acid, Melilotate, 2-hydroxybenzenepropanoic acid) 是一种内源性代谢产物。 |
| S2987 | 4-Methyl-2-oxovaleric acid | 4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) 是由星形胶质细胞释放至神经元，可以通过氨基转移酶重新形成亮氨酸。4-Methyl-2-oxovaleric acid 可降低骨骼肌中蛋白质的降解速率。4-Methyl-2-oxovaleric acid 可通过抑制 alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) 的活性来发挥 oxidative phosphorylation (OXPHOS) 的解偶联剂和代谢抑制剂的功效。 |
| S3266 | L-Anserine nitrate salt | L-Anserine nitrate salt 是一种存在于大多数动物组织中的二肽，具有抗氧化、抗交联和抗糖基化的作用。L-Anserine 可防止内质网应激诱导物诱导的神经毒性。 |
| S1273 | Amarogentin | Amarogentin (AG) 是一种主要从 Swertia 和 Gentiana 根中提取的裂环烯醚苷，具有抗氧化、抗肿瘤和抗糖尿病的作用。Amarogentin 是苦味受体 TAS2R1 的激动剂，可抑制LAD-2细胞中substance P诱导的新合成的 TNF-α 的产生。Amarogentin 通过 G2/M 细胞周期的阻滞和 PI3K/Akt 信号通路诱导人胃癌细胞（SNU-16）的凋亡。Amarogentin (AG) 可与 AMP-activated protein kinase (AMPK) 的α2亚基相互作用，并激活三聚体激酶，其EC50值为277 pM。 |
| S0923 | Isoliquiritin apioside | Isoliquiritin apioside (ISLA, ILA) 是一种分离自 Glycyrrhizae radix rhizome (GR) 的成分，可显著地降低PMA诱导的 matrix metalloproteinase (MMP) 的活性增加并抑制了PMA-诱导 mitogen-activated protein kinase (MAPK) 和 NF-κB 的活化。Isoliquiritin apioside 在恶性癌细胞和EC中具有抗转移和抗血管生成的能力，并且没有细胞毒性。 |
| S2869 | Adamantane | Adamantane 是一种无色结晶的、带有类似樟脑气味的化合物，首次获得是从石油中分离出的。Adamantane 可用于治疗 influenza A virus 感染。 |
| S9690 | Caerulein (FI-6934) | Caerulein (Ceruletide, Cerulein, FI-6934) 是一种 cholecystokinin (CCK) receptor 的激动剂，也是一种安全有效的胆囊代谢药，是小肠和胰腺外分泌的兴奋剂。 |
| S6924 | D-Luciferin sodium salt | D-Luciferin (D-(-)-Luciferin, Firefly luciferin) sodium salt 是萤光素酶的天然底物，可催化生物发光昆虫产生光。 |
| S3290 | Procyanidin B2 | Procyanidin B2 (PCB2) 是一种存在于常见食品中的天然类黄酮，具有抗炎、抗氧化和抗癌活性。Procyanidin B2 可激活 PPARγ 并诱导小鼠巨噬细胞M2极化。Procyanidin B2 可显著抑制百草枯在大鼠模型中肺组织中 NLRP3 炎性小体的活化。 |
| S9700 | Tapinarof | Tapinarof (GSK2894512, Benvitimod, WBI 1001, DHPS, DMVT 505) 是一种 aryl hydrocarbon receptor (AhR) 的天然激动剂，可诱导永生化角质形成细胞(HaCaT)中AhR的核易位，EC50值为0.16 nM。Tapinarof 可以以剂量依赖的方式诱导CD4+ T细胞的凋亡，其IC50值为5.2 μM。 |
| S6919 | Brevilin A | Brevilin A (6-O-Angeloylplenolina) 是一种从Centipeda minima分离得到的倍半萜内酯，是 STAT3 的选择性抑制剂，可通过阻断JAKs酪氨酸激酶结构域 JH1 来减弱 JAKs 的活性。Brevilin A 可通过线粒体途径和 PI3K/AKT/mTOR 失活来诱导结肠腺癌细胞CT26的凋亡和自噬。 |
| S0924 | Pteryxin | Pteryxin ((+)-Pteryxin) 是一种在 Apiaceae 伞形科中发现的二氢吡喃香豆素衍生物，也是一种有效的 butyrylcholinesterase (BChE) 的抑制剂，IC50值为12.96 μg/ml。Pteryxin 可抑制LPS诱导的小鼠腹膜巨噬细胞中 nitric oxide 的产生，其IC50值为20 μM。Pteryxin 具有治疗阿尔茨海默氏病 (AD) 的潜力。 |
| S0973 | Wilforgine | Wilforgine 是 Tripterygium wilfordii Hook. F.中主要的生物活性倍半萜生物碱之一，可在M. separata larvae的肌肉中诱导显微结构和超微结构变化，其发挥作用的位置是肌肉系统中的 calcium receptors or channels。 |
| S3254 | Plantagoside | Plantagoside 是一种从 Plantago asiatica 的种子中分离出的黄烷酮葡糖苷，是一种特异性的、非竞争性的 alpha-mannosidase 的抑制剂，IC50值为5 μM。 |
| S3253 | Xylobiose | Xylobiose (1,4-β-D-Xylobiose, 1,4-D-Xylobiose) 是由木糖单体形成的二糖，是一种天然的底物，可以被来源于 Selenomonas ruminantium (SXA)的β-D-木糖苷酶/α-L-阿拉伯呋喃糖苷酶水解。 |
| S3252 | Xylotriose | Xylotriose (1,4-b-D-Xylotriose, 1,4-beta-D-xylotriose) 是一种天然的木寡糖底物，可以被来源于 Selenomonas ruminantium (SXA)的催化有效的β-D-木糖苷酶水解。 |
| S3222 | Raspberry ketone glucoside | Raspberry ketone glucoside (RKG) 是来源于树莓果实的天然产物，是一种抗氧化剂antioxidant，对黑色素 melanin 的合成具有抑制作用。 |
| S3223 | L-Quebrachitol | L-Quebrachitol (L-QCT) 是可从许多植物中分离出来的天然产物，促进增殖和细胞DNA合成。L-Quebrachitol 可上调 bone morphogenetic protein-2 (BMP-2)、runt-related transcription factor-2 (Runx2) 和 mitogen-activated protein kinase (MAPK) 相关调控基因和 Wnt/β-catenin 信号通路，同时下调 nuclear factor-κB(NF-κB) 配体 (RANKL) 受体激活剂的mRNA水平。 |
| S3226 | Dehydroabietic acid | Dehydroabietic acid (DAA, DHAA) 是一种天然的二萜树脂酸，衍生自针叶植物（如 Pinus 和 Picea）通过抑制 Src、Syk 和 TAK1 介导的通路来产生抗炎活性。 |
| S3278 | Kaempferol-3-O-neohesperidoside | Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) 是一种从Primula latifolia Lapeyr. 和 Primula vulgaris Hudson 的叶提取物中分离出的类黄酮，通过 PI3K - GSK-3 信号通路和 MAPK - PP1 通路来刺激大鼠比目鱼肌中的糖原合成 glycogen synthesis。 |
| S3289 | Daphnoretin | Daphnoretin (Dephnoretin, Thymelol) 是一种从Wikstroemia indica C.A. Mey.中提取的具有生物活性的化合物，是 protein kinase C (PKC) 的激活剂。Daphnoretin 通过调节 Akt 信号通路的活性，来抑制肿瘤细胞的增殖、侵袭和迁移，促进其凋亡。 |
| S3295 | Taxifolin 7-rhamnoside | Taxifolin 7-rhamnoside (TR, Taxifolin 7-O-rhamnoside, Taxifolin 7-O-α-L-rhamnoside) 是一种从 Hypericum japonicum 中分离出的类黄酮，其具有对抗耐甲氧西林金黄色葡萄球菌 (MRSA).的临床分离株的抗菌活性。 |
| S3224 | Cinobufagin | Cinobufagin (Cinobufagine) 是 Venenum Bufonis 的活性成分，可抑制肿瘤发展。Cinobufagin 可提高 ATM 和 Chk2 并降低 CDC25C、CDK1 和 cyclin B。Cinobufagin 抑制 PI3K、AKT 和 Bcl-2，同时增加裂解的 caspase-9 和 caspase-3 水平。由此诱导细胞周期停滞在G2/M期及凋亡。 |
| S3230 | L-Fucitol | L-Fucitol (1-Deoxy-D-galactitol) 是一种分离自 Myristica fragrans (Nutmeg) 的半乳糖醇类似物，可抑制大肠杆菌K12的半乳糖醇阳性菌株。 |
| S3233 | Emetine hydrochloride | Emetine hydrochloride (NSC 33669) 是一种从吐根 ipecac 根部提取的主要生物碱，在临床上被用作催吐和抗原生动物药物，可降低 HIFs (hypoxia-inducible factors; HIF-1α and HIF-2α)、PDK1、RhoA、Rho-kinases (ROCK1 and ROCK2) 和 BRD4。Emetine hydrochloride 可抑制细胞的自噬，并具有抗疟疾、抗病毒、抗细菌和抗变形虫的作用。 已取得危险化学品经营许可 |
| S3236 | Mesaconitine | Mesaconitine 是Aconiti tuber附子块茎中的附子生物碱之一，通过从细胞外空间流入Ca2+来增加内皮细胞中的[Ca2+]i水平。 |
| S3238 | Resibufogenin | Resibufogenin (Bufogenin, Recibufogenin) 是huachansu华蟾素中具有抗癌作用的成分，通过上调 receptor-interacting protein kinase 3 (RIP3) 和磷酸化 mixed lineage kinase domain-like protein 的Ser358位点来触发坏死病。Resibufogenin 可通过诱导 reactive oxygen species (ROS) 积累发挥细胞毒性作用。Resibufogenin 可诱导凋亡和 caspase-3 和 caspase-8 活性。Resibufogenin 增加 Bax/Bcl-2 表达，并抑制 cyclin D1、cyclin E、PI3K、p-AKT、p-GSK3β 和 β-catenin 的蛋白表达。 |
| S3245 | Nodakenetin | Nodakenetin (NANI) 是从Angelica decursiva中分离出的植物性香豆素，可抑制 α-glucosidase、PTP1B、rat lens aldose reductase (RLAR)、AChE、BChE 和 β-site amyloid precursor protein cleaving enzyme 1 (BACE1)。Nodakenetin 可改变 Bax 和 Bcl-2 的蛋白质表达，并促进线粒体凋亡。Nodakenetin 具有抗肿瘤活性。 |
| S3251 | Goitrin | Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) 是板蓝根 Radix isatidis 的主要成分之一，广泛用于治疗发烧、清热的传统中药。Goitrin 具有抗病毒和抗内毒素活性。 |
| S3262 | Scopolin | Scopolin 是一种从 Arabidopsis thaliana (Arabidopsis) 中分离的香豆素，它通过激活 SIRT1 介导的信号级联反应来减轻肝脏脂肪变性，SIRT1介导的信号通路是脂质稳态的有效调节剂。 |
| S3267 | Kaempferol-3-O-rutinoside | Kaempferol-3-O-rutinoside (Nicotiflorin, Nikotoflorin, Kaempferol 3-O-β-rutinoside) 是从 Carthamus tinctorius 中提取的黄酮，可改变受伤神经元的形状和结构，减少凋亡细胞，下调 p-JAK2、p-STAT3、caspase-3 和 Bax 的表达，并降低Bax免疫反应性，并增加 Bcl-2 蛋白表达和免疫反应性。 |
| S3271 | Caudatin | Caudatin (Cauldatin)，一种来源于 Cynanchum auriculatum (C. auriculatum) 的C-21类固醇激素，可通过触发细胞周期阻滞和凋亡，在体外和体内均有效地抑制人神经胶质瘤的生长。 |
| S3273 | Hypericin | Hypericin (Hyp, HY) 是一种在 common St. John's Wort (Hypericum species) 中发现的天然物质，具有抗抑郁、抗肿瘤和抗病毒 (人类免疫缺陷病毒HIV和丙型肝炎病毒HCV) 活性。Hypericin 对 MAO (monoaminoxidase)、PKC (protein kinase C)、dopamine-beta-hydroxylase、reverse transcriptase、telomerase 和 CYP (cytochrome P450)。 |
| S3291 | Myristicin | Myristicin (Myristicine) 是一种在 Myristica fragrans 的种子 Nutmeg 中的萜烯样活性成分，是 monamine oxidase (MAO) 的弱抑制剂和 CYP1A2 的机理抑制剂。 |
| S3296 | Hispidulin | Hispidulin (Dinatin) 是一种在许多传统中草药中存在的天然活性成分，对癌蛋白激酶 Pim-1 具有抑制活性，其IC50值为2.71 μM。Hispidulin 通过 mitochondrial dysfunction 来诱导凋亡，并可抑制HepG2癌细胞中的 P13k/Akt 的信号通路。Hispidulin 通过激活 AMPK 信号通路发挥抗骨质疏松和骨吸收减弱的作用。 |
| S3300 | Desoxyrhaponticin | Desoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体，是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂，在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。 |
| S3301 | Cynarin | Cynarin (Cynarine) 是一种来自artichoke洋蓟的植物化学成分，具有多种药理特性，包括自由基清除、抗氧化剂、抗组氨酸和抗病毒活性。Cynarin 可阻断T细胞受体的 CD28 和抗原呈递细胞的 CD80 之间的相互作用。Cynarin 可触发 Nrf2 的核易位，恢复 glutathione (GSH) 和 reactive oxygen species (ROS) 的平衡，并抑制线粒体去极化。 |
| S3305 | Medicagenic acid | Medicagenic acid (Castanogenin) 是一种分离自 Herniaria glabra L. 的具有生物活性的三萜类五环糖苷，对 xanthine oxidase、collagenase、elastase 和 tyrosinase 具有低抑制活性。 |
| S3240 | Phaseoloidin | Phaseoloidin 是一种来自烟草毛状线虫的高纯酸糖苷，有助于植物抵抗鳞翅目草食动物。Phaseoloidin 具有抗补体 anti-complement 的作用。 |
| S3242 | Loureirin B | Loureirin B (LB, LrB)，是从Dracaena cochinchinensis中提取的类黄酮，是 PAI-1 的抑制剂，其IC50值为26.10 μM。Loureirin B 可下调TGF-β1刺激的成纤维细胞中的 p-ERK 和 p-JNK。Loureirin B 主要通过增加Pdx-1、MafA、细胞内ATP水平来促进胰岛素分泌，抑制 KATP 电流，Ca2+ 进入细胞内。 |
| S3246 | Picfeltarraenin IB | Picfeltarraenin IB 是从 Picriafel-terrae 中分离出的葫芦素糖苷，是 acetylcholinesterase (AChE) 的抑制剂。Picfeltarraenin IB 可用于治疗疱疹感染，癌症和炎症。 |
| S3260 | 3'-hydroxy Puerarin | 3'-hydroxy Puerarin 是从 Puerariae Lobatae Radix 中分离出的异黄酮。 |
| S3264 | Atractyloside potassium salt | Atractyloside potassium salt (ATR potassium salt) 是一种从 Xanthium sibiricum (Cang'erzi) 果实中分离出的毒性二萜糖苷，是一种有效的、特异性的 mitochondrial ADP/ATP carriers的抑制剂。Atractyloside potassium salt 可抑制大鼠心脏线粒体膜的 chloride channels。 |
| S3269 | Acetylcorynoline | Acetylcorynoline 是衍生自中草药 Corydalis bungeana 的主要生物碱成分，具有抗炎特性。Acetylcorynoline 可能通过降低 egl-1 的表达来抑制细胞凋亡通路，并增加 rpn5 的表达来增强 proteasomes 的活性。 |
| S3270 | Genipin 1-O-beta-D-gentiobioside | Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) 是从栀子 Gardenia jasminoides Ellis 中分离到的一种生物活性类环烷苷，具有保肝、抗炎、抗氧化和抗血栓形成的功能。 |
| S3275 | Senkyunolide I | Senkyunolide I (SEI, SENI) 是一种从 Ligusticum chuanxiong 中提取的口服活性化合物，具有止痛、抗偏头痛、神经保护、抗氧化和抗凋亡的活性。Senkyunolide I (SEI, SENI) 可上调 Erk1/2 的磷酸化，并诱导 Nrf2 的核易位，伴随着HO-1和NQO1的表达增强。Senkyunolide I (SEI, SENI) 可提高 Bcl-2/Bax 的比例，并抑制裂化的 caspase 3 和 caspase 9 的表达。 |
| S3297 | Hosenkoside A | Hosenkoside A 是从 impatiens balsamina 种子中分离出来的一种生物活性的葡糖苷。 |
| S3303 | Cyperotundone | Cyperotundone (CYT) 是在 Chuanxiong Rhizoma 和 Cyperi Rhizoma (CRCR) 中治疗偏头痛的有效成分。 |
| S3307 | Galangin 3-methyl ether | Galangin 3-methyl ether (3-O-Methylgalangin, 3-Methylgalangin) 分离自 Lychnophora markgravii 的地上部分，具有很强的抗细菌和抗真菌作用。 |
| S3308 | Caftaric acid | Caftaric acid (CA, Caffeoyl tartaric acid) 是一种具有抗氧化和抗炎作用的天然产物。 |
| S3276 | Hosenkoside K | Hosenkoside K 是从 impatiens balsamina 种子中分离出来的一种生物活性的葡糖苷。 |
| S6906 | Capric acid | Capric acid (DA, Decanoic acid, Decylic acid) 是在椰子油和棕榈油中天然存在的中链甘油三酯的成分，可通过直接抑制 AMPA receptor 来控制癫痫发作。癸酸还是 PPARs 的调节配体。由于其特殊的熔化范围，产品可能是固体、液体或半固体状态。 |
| S6899 | Licochalcone D | Licochalcone D (Lico D, LCD, LD) 是一种从中草药甘草 Glycyrrhiza inflata 中分离出的类黄酮，具有抗氧化、抗炎和抗癌的特性。Licochalcone D 可抑制LPS信号通路中NF-κB p65的磷酸化。Licochalcone D 可抑制 JAK2、EGFR 和 Met (c-Met) 活性，并诱导ROS依赖性的凋亡。Licochalcone D 还可诱导 caspases 的活化和 poly (ADP-ribose) polymerase (PARP) 的裂解。 |
| S3265 | 9''-Methyl salvianolate B | 9''-Methyl salvianolate B (9'-methyllithospermate B, 9'-Methyl lithospermate B, 9'''-Methyl salvianolate B) 是丹参 Radix Salviae Miltiorrhizae 的乙醇提取物中的活性成分。 |
| S6885 | Ailanthone | Ailanthone (AIL, Δ13-Dehydrochaparrinone) 是一种来自臭椿Ailanthus altissima的天然通过抗肝癌(HCC)成分，可通过降低 cyclins 和 CDKs 的表达、提高 p21 和 p27 的表达来诱导G0/G1期细胞周期阻滞。Ailanthone 可触发DNA损伤，其特征为 ATM/ATR 通路的激活。Ailanthone 可在Huh7细胞中诱导线粒体介导、涉及 PI3K/AKT 信号通路的细胞凋亡。Ailanthone 也是全长 Androgen Receptor (AR-FL)和组成型活性截断AR剪接变体(AR-Vs, AR1-651)的抑制剂，对应的IC50值分别为69 nM和309 nM。 |
| S0917 | Allosecurinin | Allosecurinine (Phyllochrysine) 是一种从 M.indica 和 M.discoidea 分离的具有抗真菌活性的Securinega生物碱。 |
| S0906 | 6-Methoxydihydroavicine | 6-Methoxydihydroavicine (6-Methoxy Dihydrosanguinarine) 是一种从红景天的果实中分离得到的生物碱，具有抗菌、杀虫和抗肿瘤的作用。 |
| S3288 | Absinthin | Absinthin (Absynthine) 是一种来自 Artemisia absinthium 的天然三萜内酯，具有抗炎特性。Absinthin (Absynthine) 可显著地增强 matrix metalloproteinase-8 (MMP-8) 的表达，并且是潜在的急性肺损伤(ALI)的候选治疗药物。 |
| S3287 | Rosamultin | Rosamultin 是一种从 Potentilla anserina L. 分离的19 α-hydroxyursane-type三萜，可抑制 HIV-1 protease。Rosamultin 对H2O2诱导的氧化损伤和细胞凋亡具有保护作用。 |
| S6340 | Guanidinoacetic acid | Guanidinoacetic acid (Guanidino acetic acid, GAA, Glycocyamine, Guanidinoacetate) 正在作为一种饮食制剂被研究。Guanidinoacetic acid 对体育锻炼的男性和女性均具有潜在的人体工程学益处。 |
| S3220 | Trigonelline | Trigonelline (Trigenolline) 是一种植物生物碱，是咖啡和葫芦巴的主要成分，具有抗脱粒、抗糖尿病、抗氧化、抗炎和神经保护的作用。 Trigonelline 可抑制FcεRI介导的细胞内信号通路，例如 PLCγ1、PI3K 和 Akt 的磷酸化。Trigonelline (Trigenolline) 还可抑制RBL-2H3细胞中 microtubule 的形成。 |
| S3235 | Sinapine | Sinapine 是一种从十字花科物种的种子中分离出来的生物碱，具有抗氧化、抗肿瘤和放射防护的作用。Sinapine 通过下调 P-glycoprotein 来抑制Caco-2细胞的增殖。 |
| S3261 | Myrislignan | Myrislignan 是一种分离自Myristica fragrans Houtt的木脂素并具有抗炎活性。Myrislignan 可抑制 interleukin-6 (IL-6) 和 tumour necrosis factor-α (TNF-α)。Myrislignan 剂量依赖性地抑制LPS刺激的巨噬细胞中 inducible NO synthase (iNOS) 和 cyclooxygenase-2 (COX-2) 的表达。Myrislignan 可抑制 NF-κB 信号通路的激活。 |
| S3279 | Polyphyllin B (Formosanin C) | Polyphyllin B (Formosanin C, FC) 是一种从Paris formosana分离得到的薯蓣皂苷，也是一种具有抗肿瘤活性的免疫调节剂。Polyphyllin B (Formosanin C, FC) 可诱导凋亡。 |
| S3280 | Linderene | Linderene (Lindenenol) 是从Lindera pulcherrima中分离出来的呋喃倍半萜类，具有抗菌和抗氧化活性。 |
| S3281 | Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobioside | Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobioside (Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobiosiden, Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside) 是一种Descurainiae Semen的活性成分。 |
| S3298 | Caulophylline (N-Methylcytisine) | Caulophylline (N-Methylcytisine, Caulophyllin, NMC) 是一种具有抗炎活性的三环喹喔啉生物碱。Caulophylline 可与鱿鱼视神经节的 nicotinic acetylcholine receptors (nAChR) 结合，Kd值为50 nM。Caulophylline 可显著地降低 myeloperoxidase (MPO) 的活性，并通过抑制 IκB 和 IKK 磷酸化来阻断 NF-κB 的活化。 |
| S3302 | β,β-dimethyl-acryl-alkannin | β,β-dimethyl-acryl-alkannin (AN-I, β,β-Dimethylacrylalkannin) 是一种从 Arnebia nobilis Reichb.f. 的根中分离出来的萘醌，有潜力成为抗衰老成分。 |
| S3304 | Stylopine | Stylopine ((R,S)-Stylopine, Tetrahydrocoptisine) 可降低LPS刺激引起的 nitric oxide (NO)、prostaglandin E2 (PGE2)、tumor necrosis factor-alpha (TNF-alpha)、interleukin-1beta (IL-1beta) 和 IL-6 的生成，以及 cyclooxygenase-2 (COX-2) 的活性。Stylopine 是 Chelidonium majus L 的叶子的主要成分。 |
| S3306 | 1,1,1,1-Kestohexaose | 1,1,1,1-Kestohexaose 是crested wheatgrass叶中的主要DP 6果聚糖。 |
| S3205 | Perillaldehyde | Perillaldehyde (Perilladehyde, Perillal, PAE, PA) 是紫苏 Perilla frutescens（一种传统的抗氧化剂）的主要成分，可抑制BaP诱导的 AHR 的活化和 ROS 的产生，抑制 BaP/AHR 介导的 CCL2 chemokine 的释放，并激活 NRF2/HO1 抗氧化剂途径。 |
| S3227 | 5,7-Dimethoxyflavone | 5,7-Dimethoxyflavone (5,7-DMF) 是一种 cytochrome P450 (CYP) 3As 的抑制剂，可显著地降低肝脏中CYP3A11和CYP3A25的表达。5,7-Dimethoxyflavone (5,7-DMF) 也是一种有效的 Breast Cancer Resistance Protein (BCRP, ABCG2) 的抑制剂。5,7-Dimethoxyflavone (5,7-DMF) 是Kaempferia parviflora的主要成分之一，具有抗肥胖、抗炎和抗肿瘤作用。 |
| S3237 | Deoxyaconitine | 3-Deoxyaconitine 是一种从 Aconitum Carmichaeli Debx 的根中分离出来的二萜类生物碱。 |
| S3241 | Loureirin A | Loureirin A 是一种黄酮类化合物，从被称为龙血的来源于Dracaena cochinchinensis的红色树脂中提取出来。Loureirin A 可通过破坏 PI3K/Akt 信号传导来抑制血小板platelet活化。Loureirin A 可抑制 Akt 磷酸化。 |
| S3247 | Icariside I | Icariside I (Icarisid I) 是 Epimedii Folium 的主要成分之一，可显着刺激细胞增殖和成骨细胞分化。 |
| S3249 | Corypalmine | Corypalmine ((R)-(+)-Corypalmine)，一种从 Stephania cepharantha 分离的生物碱，是 prolyl endopeptidase/oligopeptidase (PREP/POP) 的抑制剂，IC50值为128.0 μM。 |
| S3255 | Pectolinarigenin | Pectolinarigenin 是 Cirsium chanroenicum 中的一种抗炎活性成分，是 cyclooxygenase-2 (COX-2) 和 5-lipoxygenase (5-LOX) 的双效抑制剂。 |
| S3256 | Tectochrysin | Tectochrysin (Techtochrysin, NSC 80687) 是Alpinia oxyphylla Miquel的主要类黄酮之一。Tectochrysin 可显著地增加DR3、DR4 和 Fas的表达，并抑制 NF-κB 的活性。Tectochrysin 可诱导细胞凋亡。 |
| S3257 | Rebaudioside B | Rebaudioside B (Reb B) 是一种从甜叶菊 Stevia rebaudiana 分离的次要甜菊醇糖苷(SGs)之一，并且比许多主要SG具有更好的口感品质。 |
| S3259 | Rebaudioside D | Rebaudioside D (Reb D) 是在甜叶菊 Stevia rebaudiana (Bertoni) 的叶子中发现的几种糖苷(SGs)之一，这种糖已被鉴定为潜在的甜味剂。 |
| S3272 | Steviol (Hydroxydehydrostevic acid) | Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902) 是甜味化合物甜菊糖的主要代谢产物，可抑制 CFTR 的活性，降低 AQP2 的表达并促进AQP2降解。 |
| S3274 | Glucosyl-vitexin | Glucosyl-vitexin (Glucosylvitexin) 是小米中主要的C-糖基黄酮，可抑制 thyroid peroxidase (TPO) 的活性。 |
| S3282 | Rebaudioside M | Rebaudioside M 是一种从甜叶菊Stevia rebaudiana Bertoni中分离的天然无热量潜在甜味剂，可应用于食品和饮料产品。 |
| S3283 | Marmesin | Marmesin (S-(+)-Marmesin, (+)-Marmesin, (S)-Marmesin) 是一种具有 COX-2 和 5-LOX 双重抑制作用的天然香豆素。 |
| S3284 | Tracheloside | Tracheloside 是一种从 Carthamus tinctorius 的种子中分离得到的木脂素糖苷，具有抗雌激素作用。Tracheloside 可显著地降低 alkaline phosphatase (AP)(一种雌激素诱导性标记酶) 的活性，IC50为 0.31 μg/ ml。Tracheloside 通过刺激 ERK1/2 来促进角质形成细胞的增殖。 |
| S3285 | Dihydrolycorine | Dihydrolycorine 是lycorine的衍生物，它是从 Lycoris radiata 草药中分离出来的生物碱。Dihydrolycorine 可阻断腹水细胞中的蛋白质合成并在体内稳定HeLa细胞多核糖体。Dihydrolycorine 具有降压和神经保护的作用。 |
| S3299 | Demethyleneberberine | Demethyleneberberine (DMB) 是黄柏Cortex Phellodendri Chinensis (CPC) 的成分，可显著地缓解体重减轻并降低 myeloperoxidase (MPO) 活性，同时显著地减少促炎细胞因子的生成，例如 interleukin (IL)-6 和 tumor necrosis factor-α (TNF-α)，并抑制 NF-κB 信号通路的激活。Demethyleneberberine (DMB) 可以通过激活 AMPK 途径改善NAFLD (非酒精性脂肪肝疾病)。 |
| S0553 | Butyl isobutyl phthalate | Butyl isobutyl phthalate (BIP) 是一种从 Laminaria japonica 的根状茎中分离出来的，α-glucosidase 的非竞争性抑制剂，其IC50值为38 μM。Butyl isobutyl phthalate 具有显著的降血糖作用和治疗糖尿病的潜力。 |
| S3206 | 5a-Pregnane-3,20-dione | 5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) 是一种内源性的孕酮代谢物。5a-Pregnane-3,20-dione 可使肌动蛋白actin解聚，并降低 actin 和 vinculin 的表达。5a-Pregnane-3,20-dione 可通过影响粘附和细胞骨架分子来参与促进乳腺瘤形成和转移。 |
| S2440 | Vindesine sulfate | Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS) 是一种提取自 Catharanthus roseus的长春花生物碱，是一种有效的有丝分裂 mitosis 的抑制剂，并具有抗肿瘤的活性。Vindesine 与有丝分裂纺锤体的微管蛋白结合，可导致微管结晶和有丝分裂阻滞或细胞死亡。 |
| S0949 | Cucurbitacin IIb | Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) 可抑制 STAT3、JNK 和 Erk1/2 的磷酸化，而增强 IκB 和 NF-κB 的磷酸化，阻止 NF-κB 的核易位并降低 IκBα 和 TNF-α 的mRNA表达水平。Cucurbitacin IIb 是从Hemsleya amabilis 中分离出来的，具有抗炎活性并可诱导凋亡。 |
| S6852 | Gossypol | Gossypol (BL 193) 是一种从棉籽和根中分离出来的口服活性的多酚。Gossypol 是一种 5α-reductase 1 和 3α-hydroxysteroid dehydrogenase 的有效抑制剂，在无细胞试验中，对应的IC50值分别为3.33 μM和0.52 μM。Gossypol 还可抑制BH3肽与Bcl蛋白的结合，对 Bcl-XL 和 Bcl-2 的IC50值分别为0.4 μM和10 μM。Gossypol 在各种癌细胞中可诱导凋亡和细胞的生长抑制。 |
| S3210 | 3'-Hydroxy-4'-methoxyacetophenone | 3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) 是一种具有消炎潜能的活性多刺疟原虫提取物。 |
| S3213 | Veratryl alcohol | Veratryl alcohol (VA, Veratrole alcohol, 3,4-Dimethoxybenzyl alcohol) 是一种木质素降解真菌的次生代谢产物，是木质素过氧化物酶 Lignin peroxidase (LiP) 的天然底物。 |
| S3214 | Veratraldehyde (3,4-Dimethoxybenzaldehyde) | Veratraldehyde (3,4-dimethoxybenzaldehyde, VD, VAD, VAld, Verapamil Related Compound E, Methylvanillin) 是一种香兰素的衍生物，是从薄荷，生姜，波旁香草和树莓等水果中发现并分离出来的化学物质。Veratraldehyde 由于其令人愉悦的木质香气而被广泛用作调味剂和增香剂。Veratraldehyde 还可用作氧化还原循环剂。 |
| S3215 | 2-O-α-D-Glucopyranosyl-L-ascorbic acid | 2-O-α-D-Glucopyranosyl-l-ascorbic acid (AA-2G)，是抗坏血酸ascorbic acid (AA)的葡糖苷衍生物，在酶水解为抗坏血酸ascorbic acid后显示出维生素C的活性。AA-2G的抗肿瘤活性是由AA-2G快速水解释放的AA产生的ROS引起的。 |
| S3203 | D-Alanine | D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) 是一种 glycine site of the N-methyl-d-aspartate (NMDA) receptor 的内源性激动剂。 |
| S3293 | Gardenoside | Gardenoside 是一种从Gardenia栀子属果实中提取的天然化合物，具有保肝作用。Gardenoside 可抑制 TNF-α、IL-1β、IL-6 和 NFκB 的活化。Gardenoside 还对游离脂肪酸(FFA)诱导的细胞脂肪变性具有抑制作用。Gardenoside 可通过调节 P2X3 和 P2X7 受体来减轻慢性压迫性损伤大鼠的疼痛。 |
| S3292 | Falcarindiol | Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) 是一种天然的聚乙炔化合物，存在于伞形科的许多植物中。Falcarindiol 可抑制LPS刺激的 inducible nitric oxide synthase (iNOS)、tumor necrosis factor alpha (TNFα)、interleukin-6 (IL-6) 和 interleukin-1 beta (IL-1β) 的表达。Falcarindiol 可减弱LPS诱导的 JNK、ERK、STAT1 和 STAT3 信号分子的激活。Falnidamol 是一种具有抗癌活性的嘧啶嘧啶类化合物。 |
| S3263 | Agarotetrol | Agarotetrol 是一种在沉香树的水提取物中高浓度的酮衍生物。Agarotetrol 可通过加热产生LAC而有助于沉香木的香味。 |
| S3216 | Uridine 5'-diphosphoglucose disodium salt | Uridine-5'-diphosphoglucose (UDPG, UDP-Glc, UDP-D-Glucose, UDP-α-D-Glucose) 可激活神经免疫系统GPCR P2Y(14) receptor。Uridine-5'-diphosphoglucose 是动物组织和某些微生物中含葡萄糖的寡糖，多糖，糖蛋白和糖脂的前体。 |
| S3250 | Veratrine | Veratridine (Cevadine, Cevadin, Cevadene)是一种在百合科植物中发现的甾体生物碱，是 voltage-gated sodium channel 活化剂。Veratridine 会在大鼠中诱发类似焦虑的行为。 |
| S7904 | 2',3'-cGAMP Sodium Salt | 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium)是响应哺乳动物细胞质中的DNA产生的，并能以高亲和力结合 STING，且有效地诱导 interferon-β (IFNβ)。2',3'-cGAMP 结合 STING 的Kd值为3.79 nM。 |
| S6630 | Dimethylcurcumin (ASC-J9) | Dimethylcurcumin (ASC-J9, Dimethyl curcumin, GO-Y025)是一种 androgen receptor (AR) 降解促进剂，可通过降解全长和剪接变异体的雄激素受体来抑制去势抵抗性前列腺癌的生长。 |
| S2766 | Glycerol | Glycerol (Glycerin)是一种透明，无色和粘稠的液体，可用作润肤剂，溶剂或甜味剂。Glycerol 可改变了聚丙烯酰胺核蛋白凝胶的分离特性。 |
| S8587 | Withaferin A | Withaferin A (WA, WFA)可通过对硫代烷基化敏感的氧化还原机制阻止肿瘤坏死因子诱导的IκB激酶β的激活，从而有效地抑制 NF-κB 激活。Withaferin A 可与中间丝状体蛋白(IF) vimentin 结合，并具有抗肿瘤和抗血管生成活性。Withaferin A 是一种从 Withania somnifera 分离的甾体内酯。 |
| S2653 | 9-amino-CPT (9-Aminocamptothecin) | 9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin)是一种 Topoisomerase I 抑制剂并具有有效的抗癌活性。9-amino-CPT (9-Aminocamptothecin) 是喜树碱的一种具有活性的、不溶于水的衍生物。 |
| S8620 | 6-Diazo-5-oxo-L-norleucine | 6-Diazo-5-oxo-L-norleucine (Diazooxonorleucine, L-6-Diazo-5-oxonorleucine, DON)是一种从链霉菌中分离出来的抗生素，一种 glutaminase 的拮抗剂对cKGA（肾脏型谷氨酰胺酶）的IC50值约为1 mM。6-Diazo-5-oxo-L-norleucine 具有止痛，抗菌，抗病毒和抗癌的特性。 |
| S2654 | Neoruscogenin | Neoruscogenin 是从 R. rhizoma 中分离的天然皂苷元。Neoruscogenin 是一种有效且高亲和力的 RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1) 的激动剂。 |
| S8970 | HQNO | HQNO (2-heptyl-4-hydroxyquinoline-N-oxide)是一种由 P. aeruginosa 分泌的天然喹诺酮。HQNO 也是一种 electron transport chain 的有效抑制剂，其对呼吸链的泛醇-亚铁色素c氧化还原酶区段(Complex III)的Kd值为64 nM。在50 μM menadione存在下，HQNO 还是细菌和线粒体的 Type II NADH : quinone oxidoreductase (NDH-2) 的抑制剂，在50 μM menadione存在的条件下，其IC50值为7.3 μM。 |
| S7895 | Thapsigargin | Thapsigargin 是一种有效的、非竞争性的 the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) 的抑制剂，对carbachol诱导的[Ca2+]i瞬变在存不存在KCl预刺激条件下的IC50值分别为0.353 nM和0.448 nM。Thapsigargin 可诱导细胞凋亡。Thapsigargin 提取自植物Thapsia garganica。 |
| S7905 | 3',3'-cGAMP | 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP)可激活内质网(ER)内源性受体 stimulator of interferon genes (STING) ，从而诱导抗病毒状态和I型IFN的分泌。 |
| S7821 | Bufalin | Bufalin (BF)是 类固醇受体共激活剂 SRC-3、SRC-1 和 Na+/K+-ATPase 的有效抑制剂。Bufalin 可与Na+/K+-ATPase的亚基α1、α2和α3结合，其Kd值分别为42.5 nM、45 nM和40 nM。Bufalin 是一种从中药蟾酥中分离出来的，具有抗癌活性的，类地高辛免疫反应的主要成分。 |
| S7862 | Rottlerin | Rottlerin (Mallotoxin, NSC 56346, NSC 94525)是一种从 Mallotus Philippinensis 纯化出来的天然化合物，一种特效的 Protein kinase 的抑制剂，对PKCδ(来自杆状病毒感染的Sf9昆虫细胞)、PKCδ(来自猪脾)和CaM kinase III的IC50值分别为3 μM、6 μM和5.3 μM。Rottlerin 还可以抑制PKCα、PKCγ、PKCβ、PKCη、CKII和PKA，其IC50值分别为30 μM、40 μM、42 μM、82 μM、30 μM和78 μM。 |
| S2447 | Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) | Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) 是一种有效的微管蛋白聚合抑制剂，IC50为3.4 μM。 |
| S6790 | Ellipticine hydrochloride | Ellipticine Hydrochloride (NSC 71795, PZE)是一种有效的 DNA topoisomerase II 的抑制剂，并通过其与 cytochromes P450 (CYP) 和 peroxidases 的氧化作用介导形成共价DNA加合物。Ellipticine Hydrochloride 是从澳大利亚的夹竹桃科常绿乔木中分离出来的具有抗肿瘤活性的天然产物。 |
| S8964 | Actinomycin D (Dactinomycin) | Actinomycin D (Dactinomycin, Act D, RASP-101)是一种从链霉菌属的土壤细菌中分离出来的重要的多肽抗生素。Actinomycin D (Dactinomycin) 可抑制 DNA repair，并使 cell cycle 停滞在G1期，其IC50值分别为0.42 μM和0.4 nM。Actinomycin D (Dactinomycin) 是 autophagy 的激活剂，可在高危慢性淋巴细胞性白血病中诱导p53依赖性细胞的死亡并延长生存期。 已取得危险化学品经营许可 |
| S2288 | Rubitecan | Rubitecan (9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000) 是一种 拓扑异构酶I topoisomerase I 的抑制剂，从中国喜树的树皮和叶子中提取。Rubitecan 也是一种具有抗肿瘤活性的口服喜树碱。 |
| S2009 | Indirubin-3'-monoxime | Indirubin-3'-monoxime (Indirubin-3'-oxime)是一种选择性的CDK抑制剂，对CDK1-cyclinB, CDK2-cyclinA, CDK2-cyclinE, CDK4-cyclinD1, CDK5-p35的IC50分别为 0.18 μM, 0.44 μM, 0.25 μM, 3.33 μM, 0.065 μM。Indirubin-3'-monoxime是一种直接、选择性的5-lipoxygenase抑制剂，IC50为7.8-10 µM。 |
| S1031 | 3-Hydroxybutyric acid | 3-Hydroxybutyric acid (3-hydroxybutanoic acid, β-Hydroxybutyric acid, BHB)是一种在I型糖尿病中升高的小分子代谢产物。 |
| S2342 | Phloretin (RJC 02792) | Phloretin (RJC 02792, NSC 407292, Dihydronaringenin)是一种二氢查尔酮，含有多元酚。 |
| S9440 | Naringenin chalcone | Naringenin chalcone (Chalconaringenin, Isosalipurpol, trans-2'4'6'4-tetrahydroxychalcone) is the main active component of tomato skin extract, has been proposed as an antioxidant, an anti-inflammatory, and a regulator of fat and sex hormone metabolism. |
| S2325 | Morin Hydrate | Morin hydrate (Aurantica) 是一种化学化合物，用来检测溶液中的铝或锡的存在，因为Morin hydrate与铝或锡可以形成特有的荧光配位络合物。 |
| S6670 | GPNA (L-γ-Glutamyl-p-nitroanilide) | GPNA (L-γ-Glutamyl-p-nitroanilide)是一种有效的谷氨酰胺 (Gln) 转运蛋白ASCT2(SLC1A5) 的选择性抑制剂，Ki为55 µM。 |
| S2210 | Sphingosine | 鞘氨醇，Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine)，是具有不饱和烃链的18个碳原子的氨基醇，它形成鞘脂的主要部分，鞘脂是一类细胞膜脂质，其中包括鞘磷脂，一种重要的磷脂。 |
| S6674 | Cytosporone B | Cytosporone B是天然存在的核孤儿受体Nur77(NR4A1) 激动剂，EC50为0.278 nM。 |
| S6474 | 3,5-diiodo-L-thyronine (3,5-T2) | 3,5-diiodo-L-thyronine (3,5-T2, NSC 90469)是甲状腺激素的内源性代谢产物。 3,5-Diiodo-l-thyronine是治疗肥胖和肝脏脂肪变性的潜在降血脂药。 |
| S9218 | Phytolaccagenin | Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phtolaccae. |
| S6653 | Nigericin (NSC 292567) sodium salt | Nigericin (NSC 292567) sodium salt是从Streptomyces hygroscopicus衍生的抗生素，通过充当H+，K+和Pb2+的离子载体起作用。Nigericin可以激活NLRP3炎性体以诱导促炎和免疫刺激过程。 |
| S3911 | Veratramine | Veratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption. |
| S9403 | Ecliptasaponin A | Ecliptasaponin A, a natural triterpenoid glucoside, has protective effects against the pulmonary fibrosis induced by bleomycin via reducing the oxidative stress, lung tissue inflammation, and the subsequent epithelial-mesenchymal transition. |
| S3928 | Baccatin Ⅲ | Baccatin Ⅲ is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It exhibits immunomodulatory and anticancer chemotherapeutic activities. |
| S4938 | Cedrol | Cedrol是一种天然存在的倍半萜烯醇，是有效的、竞争性的抑制剂，抑制CYP2B6介导的安非他酮羟化酶(bupropion hydroxylase)，Ki值为0.9 μM。它还能抑制CYP3A4介导的咪达唑仑羟基化，Ki为3.4 μM。对CYP2C8, CYP2C9和CYP2C19的活性仅有微弱的抑制作用。 |
| S3942 | Cardamonin | Cardamonin (Alpinetin chalcone)天然存在于良姜属物种的果实中，具有抗炎和抗肿瘤活性。它是一种新型的hTRPA1离子通道拮抗剂，IC50为454 nM，而不与TRPV1和TRPV4相互作用。 |
| S3756 | Methyl salicylate | Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1. |
| S3763 | Cinnamaldehyde | Cinnamaldehyde is a flavonoid that is naturally synthesized by the shikimate pathway. Its supplementation can improve glucose and lipid homeostasis in diabetic animals; a TRPA1 agonist. |
| S3605 | Borneol | Borneol是一种分离自药用植物如艾纳香、芳味冰片香木的双环类单萜化合物。它是TRPM8的激动剂，能够增加眼部表面湿润。 |
| S4787 | Methyl syringate | Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist. |
| S3867 | (E)-Cardamonin | (E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor. |
| S4714 | (-)-Menthol | (-)-Menthol (L-Menthol, Levomenthol, Menthomenthol, Menthacamphor) 是薄荷醇的左旋异构体，常被用作冷却剂，可激活TRPM8。 |
| S2332 | Neohesperidin | Neohesperidin (NSC 31048) 是一种抗氧化剂，在1,1-diphenyl-2-picryldydrazyl（DPPH）自由基清除测定中，IC50为22.31 μg/ml。 |
| S5755 | Methyl Eugenol | Methyl eugenol (4-allylveratrole, eugenyl methyl ether, O-methyleugenol), as a constituent in leaves, fruits, stems, and/or roots, is used as a flavoring agent, as a fragrance and as an anesthetic in rodents. |
| S2935 | Nicotinamide Riboside Chloride (NIAGEN) | Nicotinamide Riboside Chloride (NIAGEN)是烟酰胺核糖(NR)的氯化物盐形式。NR是维生素B3的衍生物，可作为作为NAD或NAD+的前体。NIAGEN在美国被普遍认为可安全用于食品中 |
| S3607 | Sarsasapogenin | Sarsasapogenin (SAR, Parigenin)是一种甾体皂甙元，能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活，在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。 |
| S2425 | Apocynin (NSC 2146) | Apocynin (NSC 2146, Acetovanillone, NSC 209524)是一种选择性NADPH氧化酶抑制剂，IC50 为10 μM. |
| S9332 | (+)-Dipentene | (+)-Dipentene, occurring commonly in nature as the fragrance of oranges, is a flavoring agent in food manufacturing. |
| S5578 | Cadaverine | Cadaverine is a foul-smelling diamine formed by bacterial decarboxylation of lysine that occurs during protein hydrolysis during putrefaction of animal tissue. |
| S5140 | Cinene | Cinene (Limonene, Dipentene) is a clear, colorless liquid hydrocarbon classified as a cyclic monoterpene, and is the major component in oil of citrus fruit peels. It is usually used to make fragrances and flavors. |
| S5408 | Isoprene | Isoprene, also called 2-methyl-1,3-butadiene, is usually used as a chemical raw materia. |
| S6206 | 1-Butanol | 1-Butanol是糖类和其他碳水化合物发酵的次要产物，存在于许多食物和饮料中。 |
| S6019 | 2-Phenylphenol | 2-Phenylphenol，在柠檬中发现，是一种抗真菌剂和防腐剂，用于食品调味剂中。 |
| S5429 | Diallyl sulfide | Diallyl sulfide, a thioether found naturally in garlic, is a selective inhibitor and also a substrate of CYP2E1 with an IC50 of 17.3 μM. It has protective effects against alcohol- and acetaminophen-induced hepatotoxicity in many studies. |
| S6751 | Brevianamide F | Brevianamide F, belonging to a class of naturally occurring 2,5-diketopiperazines, is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by the fungi A.fumigates and Aspergillus sp.. |
| S6359 | Purine | Purine是一种杂环芳香有机化合物，在DNA和RNA中均发挥关键作用。它还是很多生物分子，如ATP、GTP、cAMP、NADH和辅酶A的重要组成成分。 |
| S2353 | Sapogenins Glycosides | Sapogenins glycosides (Saponins)是糖苷配基或非糖类，属于天然产品Saponins部分家族。 |
| S3627 | Tryptamine | Tryptamine是一种单胺生物碱，可能作为神经调节剂和神经递质发挥作用。它是hTAAR1的激动剂，还是非选择性的serotonin receptor激动剂和羟色胺-去甲肾上腺素-多巴胺释放剂(SNDRA)。 |
| S5153 | Tetrahydroberberine | Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors. |
| S3823 | Schizandrol A | Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain. |
| S5642 | Homovanillic acid | Homovanillic acid (Vanillacetic acid) is a major catecholamine metabolite that is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain. |
| S9087 | Tenuifolin | Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production. |
| S2367 | Tetrahydropapaverine HCl | Tetrahydropapaverine (Norlaudanosine) 是TIQs的一种，是Salsolinol 和 Tetrahydropapaveroline的类似物，对多巴胺神经元具有神经毒性作用。 |
| S3937 | Pterostilbene | Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes. |
| S6428 | Wilforlide A | Wilforlide A是雷公藤多甙中的活性化合物，是用于治疗自身免疫疾病的传统中药。 |
| S5850 | Vasicine | Vasicine，可分离自A. vasica，是一种生物碱。它是天然的cholinesterase（胆碱酯酶）抑制剂，在临床前模型中具有抗胆碱酯酶活性，可用于阿尔茨海默病的治疗药物开发。 |
| S7956 | Brusatol | Brusatol (NSC 172924)，可分离自B. javanica果实，是一种NRF2抑制剂。 |
| S3781 | Ginkgolide C | Ginkgolide C (BN-52022), isolated from Ginkgo biloba leaves, is a flavone reported to have multiple biological functions, from decreased platelet aggregation to ameliorating Alzheimer disease. It is an activator of MMP-9. |
| S9513 | Senkyunolide A | Senkyunolide A is one of the major bioactive ingredients in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments. |
| S6049 | (+)-(S)-Carvone | (+)-(S)-Carvone是一种主要存在于香菜和莳萝种子油中的单萜，用于化妆品、食品和药品制备中。 |
| S6700 | Castor oil | Castor oil is a popular natural treatment for various common conditions and often used in natural beauty products. |
| S3830 | Protodioscin | Protodioscin (Furostanol I), a steroidal saponin compound found in a number of plant species, is able to stimulate testosterone production and it also has an androgen-mimetic action, binding and activating the testosterone receptors. |
| S8870 | Epibrassinolide | Epibrassinolide是一种可从多种植物中分离而来的油菜素类固醇，减少毒性，在植物应激反应下刺激其健康生长。 |
| S6701 | Corn Oil | Corn oil 是一种精制的植物油，常用于脂溶性物质的载体。 |
| S9326 | Scopolamine | Scopolamine (Skopolamin) is a tropane alkaloid derived from plants of the nightshade family, specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties. |
| S3860 | Allicin | Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects. |
| S6493 | n-Butylidenephthalide | n-Butylidenephthalide ((Z)-Butylidenephthalide, 3-Butylidenephthalide, Butylidenephthalide) 可从当归的氯仿提取物中分离出来，它具有多种生物活性，如减少心绞痛、血小板聚集、增殖、非特异性痉挛。 |
| S6601 | (±)-Equol | (±)-Equol是大豆异黄酮、黄豆苷和黄豆苷元的一种代谢物。 |
| S3687 | Urea | Urea (Carbonyldiamide, Ureophil) 是一种溶解度高的有机化合物，源自肝脏中由氨基酸脱氨基作用形成的氨。它是蛋白质分解代谢中的主要最终产物。 |
| S3839 | 1-Deoxynojirimycin | 1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus. |
| S3190 | N6-methyladenosine (m6A) | N6-methyladenosine (m6A, NSC-29409, 6-Methyladenosine, N-Methyladenosine) 是碱基修饰的腺苷类似物，在天然RNAs中作为稀有核苷。N6-methyladenosine(m6A)是mRNA的第五种碱基。 |
| S2370 | Ursolic Acid | Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol)是一种五环三萜酸，在化妆品中使用。 |
| S6426 | Hesperidin methylchalcone | Hesperidin methylchalcone源于柑橘，具有强效的抗氧化活性。 |
| S3821 | Nuciferine | Nuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. |
| S9227 | Sinensetin | Sinensetin (Pedalitin Permethyl ether), a natural polymethoxylated flavone, has potent antiangiogenesis activity. |
| S3973 | L-SelenoMethionine | L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense. |
| S2324 | Sodium Monensin (NSC 343257) | Sodium Monensin (NSC 343257)从 Streptomyces cinnamonensis中分离的, 是一种众所周知的天然的聚醚 类离子载体抗生素的代表。 |
| S2348 | Rotenone (Barbasco) | Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) 是一种植物杀虫剂，是线粒体电子传递mitochondrial electron transport的抑制剂。Rotenone 可抑制 NADH/DB oxidoreductase 和 NADH oxidase，对应的IC50值分别为28.8 nM和5.1 nM。Rotenone 可通过增强线粒体活性氧的产生来诱导凋亡。 |
| S2265 | Artesunate (WR-256283) | Artesunate (WR-256283) 是一种抗疟类药，作用于小细胞肺癌细胞系H69，IC50为< 5 μM。它是一种潜在的STAT3抑制剂，在体外对癌细胞有选择性细胞毒性作用；是有效的EXP1抑制剂。 |
| S6176 | Scyllo-Inositol | Scyllo-Inositol (Scyllitol, Cocositol, Quercinitol, AZD 103, Scyllo-Cyclohexanehexol)是一种天然存在的植物糖醇，在椰树中含量最为丰富。 |
| S6292 | (S)-2-Hydroxysuccinic acid | (S)-2-Hydroxysuccinic acid (L-Malic acid)是天然存在的苹果酸同分异构体，主要于酸性和未成熟的水果中被发现。 |
| S6346 | L-(+)-Arabinose | L-(+)-Arabinose (DL-Arabinose, Pectinose) 是一种用于鉴定、区分戊糖异构酶的底物。 |
| S6061 | DL-m-Tyrosine | DL-m-Tyrosine是一种有效的、广谱的植物毒素，从某些细叶羊茅的根部流出。 |
| S6163 | Traumatic acid | Traumatic acid (Trans-2-dodecenedioic acid)是一种植物激素，首次于损伤的绿豆中分离。它是一种有效的伤口愈合剂，是前列腺素合成的中间物。 |
| S6264 | Rutin hydrate | Rutin (Quercetin-3-O-rutinoside, Rutoside, Sophorin) 是在多种植物如柑橘中所发现的一种配糖。 |
| S6112 | Oxalacetic acid | Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid)是三羧酸循环的中间物，它与乙酰辅酶A经柠檬酸合酶催化反应生成柠檬酸盐。它还参与糖原异生、尿素循环、乙醛酸循环、氨基酸合成和脂肪酸合成等过程。Oxaloacetate是Complex II的抑制剂。 |
| S6221 | Methyl cinnamate | Methyl cinnamate 是花椒(Zanthoxylum armatum)的活性成分，是一种广泛使用的具有抗菌和 tyrosinase 抑制剂活性的天然香料化合物。Methyl cinnamate 通过激活3T3-L1前脂肪细胞中的 CaMKK2--AMPK 信号通路来抑制脂肪细胞分化。 |
| S6008 | p-Hydroxybenzaldehyde | p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol)，存在于兰花Gastrodia elata、Galeola faberi和香草中，是一种羟基苯甲醛，可与NAD+和H20反应生成4-hydroxybenzoate、NADH和两质子。 |
| S6011 | Acetamide | Acetamide (ethanamide, Acetic acid amide) 是一种有机化合物，可被用作塑化剂和工业溶剂。 |
| S6018 | 2,3,4-Trihydroxybenzoic acid | 2,3,4-Trihydroxybenzoic acid是转筋草中的酚组分，具有抗氧化活性。 |
| S6043 | 3-Indoleacetonitrile | 3-Indoleacetonitrile是一种植物生长激素，是光照诱导的生长素抑制性激素。 |
| S6045 | L-Arabinitol | L-Arabinitol (L-lyxitol)是一种糖醇，存在于所有生物中。在很多食物如甘薯、鹿果、乌头叶菜豆和欧洲栗中都有发现。 |
| S6047 | Lactose | Lactose是一种天然存在于奶及乳制品中的二糖。 |
| S6071 | 3,5-Dimethoxyphenol | 3,5-Dimethoxyphenol (Phloroglucinol dimethyl ether)是一种发现于红豆杉叶中的毒素代谢物。 |
| S6076 | Phenylacetylglutamine | Phenylacetylglutamine is a product formed by the conjugation of phenylacetate and glutamine. It is a normal constituent of human urine, but other mammals such as the dog, cat, rat, monkey, sheep, and horse do not excrete this compound. |
| S9564 | p-Hydroxy-cinnamic Acid | p-Hydroxy-cinnamic Acid在体外具有抗疟活性和体内抗骨质疏松活性。 |
| S2254 | 4-Demethylepipodophyllotoxin(NSC-122819,VM-26) | 4-Demethylepipodophyllotoxin (NSC-122819, VM-26, DMEP) is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly. |
| S2442 | Inosine | Inosine (NSC 20262, INO 495) 是一种核苷，由次黄嘌呤通过β-N9-糖苷键结合到核糖环上形成。 |
| S2280 | Chlorogenic Acid | Chlorogenic acid (NSC 407296, Heriguard) 是一种羟基肉桂酸，是天然存在的有机化合物。 |
| S6250 | L-Lactic acid | L-Lactic acid是一种天然产物，可被用作食物添加剂。 |
| S6275 | (−)-β-Pinene | (−)-β-Pinene (Nopinene)是存在于很多植物中的天然有机化合物。它对滨藜第三龄幼虫具有致死性（LD50 = 65 μg/larva）、抑制感染性支气管炎病毒的肤质（IC50 = 1.32 mM），在Vero细胞中毒性浓度CC50大于10 mM。 |
| S6287 | 3-Methylbutanoic acid | 3-Methylbutanoic acid (Isovaleric acid, Delphinic acid, 3-Methylbutyric acid, Isopentanoic acid, β-methylbutyric acid)是一种天然脂肪酸，广泛存在于多种植物和精油中。 |
| S6296 | Octanoic acid | Octanoic acid (caprylic acid)天然存在于多种哺乳动物的乳汁（奶）中，是椰子油和棕榈仁油中的微量组分。它被用于生产香水酯类，也用于制作染料。 |
| S6303 | trans-2-Hexenal | Trans-2-hexenal (Leaf aldehyde)是α,β不饱和羰基化合物，可保护植物免受有害物质侵染。 |
| S5887 | Khellin | Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin)分离自阿密茴（伞形科）种子，被用于治疗多种疾病。 |
| S2331 | Neohesperidin Dihydrochalcone (Nhdc) | Neohesperidin dihydrochalcone(Nhdc, NCI-c60764) 是源于柑橘类的一种人造甜味剂。 |
| S9432 | Ginkgolic Acid | Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT). |
| S9445 | Ginkgolic Acid (C13:0) | Ginkgolic Acid (C13:0) 是银杏中的一种天然抗龋剂，对变形链球菌(S. mutans)具有抗菌活性，并能抑制与其致龋性相关的特定毒力因子。银杏酸是一种有效的 sumoylation 抑制剂，据报道可抑制 histone acetylation transferase (HAT) 。 |
| S2360 | Solanesol (Nonaisoprenol) | Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants. |
| S2369 | Troxerutin | Troxerutin 是一种黄酮醇类，是一种黄酮类化合物。 |
| S5934 | (-)-Fenchone | Fenchone是苦艾酒中的组分，是茴香中的香精油。在食物和香水中，它被用做调料（香料）。 |
| S6055 | (S)-(−)-Limonene | (S)-(−)-Limonene是一种发现于橘皮油中的香料单萜，天然存在于草本精油、茶树油和松节油中。 |
| S6058 | β-Caryophyllene | β-Caryophyllene是一种天然存在的双环倍半萜烯，是很多精油的组分之一。它是非类固醇的抗炎药物、香料和代谢物。 |
| S6059 | cis-3-Hexen-1-ol | cis-3-Hexen-1-ol (Leaf alcohol)是一种重要的芳香族化合物，用于果蔬香精和香水中，也是捕食性昆虫的引诱剂。 |
| S6118 | Terpinen-4-ol | Terpinen-4-ol是一种天然存在的单萜，是茶树油的主要活性成分，具有多种生物活性如抗真菌活性。 |
| S6150 | Farnesyl Acetate (mixture of isomers) | Farnesyl Acetate是一种香料化合物，可在一些食物如蓝莓中发现。 |
| S6162 | 2-Octenoic acid | 2-Octenoic acid (2-Octenoate)是一种正常的有机酸，由脂族醛通过肝脏微粒体氧化产生。它是天然存在于尿液和血浆中的代谢物。 |
| S6164 | (-)-Citronellal | (-)-Citronellal是香茅油的组分，用于活性化合物的合成。 |
| S6185 | Arachidonic acid | Arachidonic acid (Arachidonate)是非饱和必需脂肪酸，在动物和人类肝脏、脑部和腺器官脂肪中都有发现。它是前列腺素、凝血噁烷和白细胞三烯的生物合成的前体化合物。 |
| S6208 | Diethyl malonate | Diethyl malonate天然存在于葡萄和草莓中，用于合成其他化合物。 |
| S9476 | Dendrobine | Dendrobine是一种分离自石斛的植物碱，用于对石斛兰Dendrobium的质量控制和鉴别。 |
| S9551 | Uvaol | Uvaol是一种从橄榄渣油的非甘油酯组分发现的五环三萜，具有促炎-抗炎活性。 |
| S4792 | N-Acetylneuraminic acid | N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes. |
| S5526 | β-Alanine | β-Alanine (beta-Alanine, 3-Aminopropanoic acid) is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activating glycine and GABA receptors. |
| S4676 | Gluconolactone | Gluconolactone是一种天然存在的聚羟基酸，具有螯合金属离子、保湿、抗氧化活性。 |
| S5851 | 4'-Methoxychalcone | 4'-Methoxychalcone存在于柑橘属植物中，是一种查耳酮衍生物，具有多种药理活性，如抗肿瘤和消炎活性。 |
| S9481 | Blinin | Blinin可从Conyza blinii中分离，在中国的西南地区被用作民间药物。 |
| S9557 | Isobergapten | Isobergapten是一种香豆素，具有调节植物生长活性。 |
| S9560 | Anisodamine Hydrobromide | Anisodamine (6-Hydroxyhyoscyamine)是天然存在的阿托品（atropine）衍生物，具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。 |
| S5865 | Hyaluronic acid | Hyaluronic acid (HA, Hyaluronan, Hyaluronate)(透明质酸)是一种带阴离子的、非硫酸化的粘多糖，在结缔组织、上皮和神经组织中广泛分布。它常用于皮肤护理。 |
| S9193 | Aristolochic acid A | Aristolochic acid A (Aristolochic Acid I, Aristolochin, Aristolochine, TR 1736)是一种致癌、致突变和具有肾毒性的试剂，来源于马兜铃科的开花植物。Aristolochic acid A 可显著降低 activator protein 1 (AP-1) 和 nuclear factor-κB (NF-κB) 的活性。 |
| S9563 | Evodine | Evodine是一种天然产物（源于吴茱萸），在中国药典中被记载作为吴茱萸质量评估的生物标志物。Evodine 也是一种有效的 P-gp 的抑制剂。 |
| S9554 | Bakkenolide A | Bakkenolide A (Fukinanolid)分离自毛裂蜂斗菜，具有抗癌活性，可对炎性细胞因子的形成发挥保护作用。 |
| S9552 | Farrerol | Farrerol是杜鹃花中一种重要的活性成分，具有抗氧化和消炎活性。 |
| S9487 | Praeruptorin C | Praeruptorin C是源于白花前胡干燥根的天然产物，具有抑制破骨细胞形成和吸收的作用。它常常在中药中被用于治疗上呼吸道感染，是解热、镇咳和促黏液溶解的试剂。 |
| S9484 | Darutoside | Darutoside源于植物提取物，通过减少炎症反应和修复胶原发挥有效的再生活性。 |
| S9480 | Raspberry Ketone | Raspberry ketone (p-Hydroxybenzyl acetone, Frambinone, Oxyphenylon, Rheosmin, Rasketone)是一种天然存在的酚类化合物，是红莓中的主要芳香化合物。 |
| S9473 | Nuzhenide | Nuzhenide (Specnuezhenide)是橄榄仁中的重要成分，属于糖脂类。 |
| S9474 | Acetylharpagide | Acetylharpagide是来源于金疮小草（Ajuga decumbens）的一种单体化合物，广泛用于治疗传染性和炎症性疾病。 |
| S5846 | Apocarotenal | Apocarotenal是一种类胡萝卜素，可存在于菠菜和柑橘类水果中，是维他命A的前体。 |
| S9475 | Hupehenine | Hupehenine是来源于湖北贝母鳞茎的甾体生物碱，具有抑制乙酰胆碱、拮抗毒蕈碱性受体、抑制胆碱酯酶的潜力。 |
| S9479 | Complanatoside A | Complanatoside A是分离自沙苑子（Astragalus complanatus）中的一种黄酮苷，可被用作沙苑子的质量控制指标。 |
| S9488 | Praeruptorin D | Praeruptorin D是前胡中的成分，具有抗肿瘤和消炎活性。 |
| S9491 | (+)-Guaiacin | (+)-Guaiacin存在于草药和香料中，属于木脂素类。 |
| S9555 | Vincristine | Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) 是长春花中的生物碱，具有抗肿瘤活性。Vincristine 可抑制有丝分裂纺锤体中的微管 microtubule 形成，其结合微管的Ki值为85 nM。 |
| S9562 | Pomolic acid | Pomolic acid是一种分离自野鸦椿（Euscaphis japonica）的五环三萜，可有效地抑制细胞生长和诱导凋亡。 |
| S9192 | Vitexin | Vitexin (Apigenin-8-C-glucoside), an naturally occuring apigenin flavone glycoside, acts as a platelet aggregation and alpha-glucosidase inhibitor and shows antineoplastic activity. |
| S3964 | Mucic Acid | Mucic Acid (Schleimsaure, Saccharolactic acid, Tetrahydroxyadipic acid, D-Glucaric acid, Galactaric acid) is the dicarboxylic sugar acid resulting from oxidation glactose with dilute nitric acid. It is a substrate of galactarate O-hydroxycinnamoyltransferase. |
| S5928 | Zerumbone | Zerumbone，分离自姜科植物，是一种天然存在的膳食化合物，具有多种生化活性，如抗增殖、抗氧化、消炎和抗癌活性。 |
| S5794 | Glycochenodeoxycholic acid | Glycochenodeoxycholic acid (Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate)是由鹅去氧胆酸盐和甘氨酸在肝脏中形成的胆汁盐。它是一种去垢剂，能溶解脂肪，促进吸收。 |
| S5820 | L-Hydroxyproline | L-Hydroxyproline (trans-4-Hydroxy-L-proline)是一种胶原特异的氨基酸。它被用作骨转换和肝纤维化的诊断标记物。 |
| S5824 | Cinnamyl alcohol | Cinnamyl alcohol是一种存在于肉桂中的天然产物。 |
| S5821 | Linoleic acid | Linoleic acid (9,12-octadecadienoic acid)是一种必需脂肪酸，用于合成花生四烯酸，存在于细胞膜脂质中。 |
| S5823 | L-Pyroglutamic acid | L-pyroglutamic acid (L-pyroglutamate, 5-Oxoproline, pidolic acid)是一种天然营养物，是来源于谷氨酸的氨基酸。它是谷胱甘肽循环的代谢物，能通过5-羟脯氨酸酶转化为谷氨酸。 |
| S5828 | L-Abrine | L-Abrine (N-Methyl-L-tryptophan)是相思子根部的毒性清蛋白，可抑制核糖体。 |
| S9367 | Adenosine disodium triphosphate | Adenosine disodium triphosphate (ATP disodium) is the sodium salt form of adenosine triphosphate (ATP), a complex organic chemical that provides energy to drive many processes in living cells. |
| S5805 | Allopregnanolone | Allopregnanolone是一种神经类固醇，在脑内由黄体酮合成而来，是高效的GABAA receptor正向别构调节剂。 |
| S5771 | Sulforaphane | Sulforaphane 是一种天然存在的异硫氰酸盐，存在于十字花科蔬菜如西兰花、卷心菜、羽衣甘蓝。它是 Nrf2 的诱导物。Sulforaphane 也是 histone deacetylase (HDAC) 和 NF-κB 的抑制剂。Sulforaphane 可增加 heme oxygenase-1 (HO-1)，并降低 reactive oxygen species (ROS) 的水平。Sulforaphane 诱导细胞周期停滞和凋亡。 |
| S9334 | 2-Pentylfuran | 2-Pentylfuran (2-Amylfuran)是天然存在的香料成分。 |
| S9383 | Methyl palmitate | Methyl palmitate (Methyl hexadecanoate, Palmitic acid methyl ester), a kind of fatty acid methyl ester, could be found in many plants and possesses acaricidal activity. |
| S9453 | 2-Undecanol | 2-Undecanol (Methyl nonyl carbinol, 2-Hydroxyundecane, 2-Hendecanol) is a fatty alcohol lipid molecule. |
| S9454 | Undecanoic acid | Undecanoic acid (Undecylic acid) is a medium chain length monocarboxylic acid that appears to be involved in the control of triacylglycerol synthesis. |
| S9385 | Ligustilide | Ligustilide is the most abundant bioactive ingredient in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments. 现配现用 |
| S9033 | Incensole acetate | Incensole acetate, isolated from Boswellia Resin, is a novel anti-inflammatory compound that inhibits NF-κB activation. |
| S9043 | 6-Shogaol | 6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties. |
| S9071 | Nootkatone | Nootkatone, a natural ingredient that occurs in grapefruit and certain other plants, has antioxidant and anti-inflammatory effects. |
| S9094 | Pogostone | Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity. |
| S9118 | Beta-Asarone | Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects. |
| S9140 | Pulegone | Pulegone, a naturally occurring organic compound, is a fragrance and flavour ingredient. |
| S9142 | Sparteine | Sparteine, which could be extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent. |
| S9236 | α-Cyperone | α-Cyperone (alpha-cyperone) 是香附子Cyperus rotundus的主要活性成分，表现出了如抗毒力、抗原毒性和抗菌活性等生物活性。α-Cyperone (alpha-cyperone) 与COX-2、IL-6、Nck-2、Cdc42 和 Rac1 的表达下调有关。 |
| S9263 | 3-n-Butylphathlide | 3-n-Butylphathlide, initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects. |
| S5370 | 10-Hydroxydecanoic acid | 10-Hydroxydecanoic acid, a minor constituent of royal jelly, is a saturated fatty acid that has cytotoxic effects. |
| S9450 | 1-Undecanol | 1-Undecanol (Undecyl alcohol, 1-Hendecanol), found naturally in many foods such as fruits (including apples and bananas), butter, eggs and cooked pork, is used as a flavoring ingredient. |
| S5761 | Citric acid | Citric acid is a weak organic acid that occurs naturally in citrus fruits. It is an intermediate in the citric acid cycle. |
| S5763 | D-Mannose | D-mannose is a naturally occurring simple sugar that may help your body cleanse the urinary tract and maintain a healthy bladder lining. |
| S5391 | α-Boswellic acid | α-Boswellic acid is a naturally occuring triterpenoic acid. |
| S5757 | Isoeugenol | Isoeugenol (4-Propenylguaiacol), an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity. |
| S5759 | Methyl linoleate | Methyl linoleate (Linoleic acid methyl ester), found in cloves, is a fatty acid methyl ester of linoleic acid which is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. |
| S5756 | Methyl Stearate | Methyl Stearate (Methyl Octadecanoate, Stearic Acid methyl ester), found in cloves, is an antifoaming agent and fermentation nutrient. |
| S5577 | 6-Biopterin | 6-Biopterin ( L-Biopterin, L-Erythro-Biopterin) is a natural product that has been considered as a growth factor for some insects. |
| S5743 | γ-Linolenic acid | γ-Linolenic Acid (18:3, n-6), the Δ6-desaturase product of linolenic acid, is an unsaturated fatty acid found primarily in vegetable oils. |
| S5600 | Flavokawain A | Flavokawain A 是一种从 kava 提取的凋亡诱导剂和抗癌剂。 Flavokawain A 可以下调抗凋亡蛋白，例如 XIAP、 survivin 和 Bcl-xL，从而改变凋亡与抗凋亡分子之间的平衡、诱导肿瘤细胞死亡。 |
| S5732 | Sebacic acid | Sebacic acid (1,8-Octanedicarboxylic acid) is a saturated, straight-chain naturally occurring dicarboxylic acid |
| S5733 | Stearic acid | Stearic acid (Octadecanoic acid, Isostearic acid, Cetylacetic acid) is a natural saturated fatty acid found in animal and vegetable fats. It could be used as a food additive and used in soaps, cosmetics and detergents. |
| S9375 | 2'-Hydroxyacetophenone | 2'-Hydroxyacetophenone is a flavouring ingredient. |
| S9379 | Dihydrocoumarin | Dihydrocoumarin, a compound found in Melilotus officinalis (sweet clover) and Dipteryx odorata Willd (tonka beans), is added as a flavoring agent to a wide variety of foods, including soft drinks, yogurt, and muffins, and is used as a common fragrance in cosmetics, lotions, and soaps. |
| S9382 | Thymine | Thymine (5-methyluracil) is one of the four nucleobases in the nucleic acid of DNA. |
| S9333 | Gibberellins A4/A7 | Gibberellins A4/A7 (Gibberellin A4 and A7) is the Gibberellin A4 Mixture With Gibberellin A7. Gibberellins A4/A7 promotes internode elongation & breaks certain dormancies in seeds. Gibberellins A4/A7 is an endogenous plant growth regulator, promotes the growth and elongation of cells. |
| S5691 | Terpinyl Acetate | Terpinyl Acetate (alpha-Terpinyl), a naturally occuring compound found in several essential oils, is a flavouring agent. |
| S5616 | 4-Methylcatechol | 4-Methylcatechol (P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol) is an inducer of nerve growth factor. It is used to synthesize antimicrobial and antioxidant. |
| S9352 | Homogentisic Acid | Homogentisic Acid (Melanic acid, 2,5-dihydroxyphenylacetic acid) is found in Arbutus unedo (strawberry-tree) honey or present in the bacterial plant pathogen Xanthomonas campestris pv. phaseoli as well as in the yeast Yarrowia lipolytica. |
| S5684 | Lapachol | Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity. |
| S5640 | Ethyl caffeate | Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro. |
| S5680 | (-)-Verbenone | (-)-Verbenone (2-Pinen-4-one), an important component of the essential oil from rosemary, is an insect pheromone with a spicy odor and camphoraceous fragrance. |
| S5617 | Myristic Acid | Myristic acid (Tetradecanoic acid) is a fatty acid that occurs naturally in some foods. Myristic acid inhibits the phosphorylation of poly E4Y by Src with an Ki of 35 μM. |
| S9046 | Berberine | Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic. |
| S9047 | Leonurine Hydrochloride | Leonurine (SCM-198), a natural alkaloid extracted from Herba leonuri, is a promising anti-glycation agent with vasodilator, antioxidative, cardioprotective and neuroprotective effects. |
| S9037 | Tenacissoside H | Tenacissoside H, a natural compound found in M. tenacissima, exerts anti-inflammatory and anti-tumor effects. |
| S9027 | Corynoxine | Corynoxine, a natural oxindole alkaloid, is a new autophagy enhancer. |
| S9041 | Corosolic acid | Corosolic acid (Glucosol, Colosic acid, 2α-Hydroxyursolic acid) is one of the pentacyclic triterpenoids isolated from Lagerstroemia speciose and has been reported to exhibit anti-cancer and anti-proliferative activities in various cancer cells. |
| S9035 | Isovitexin | Isovitexin (saponaretin, Apigenin-6-C-glucoside), an active component of many traditional Chinese medicines, has various activities, such as anti-oxidant, anti-inflammatory, anti-alzheimer disease (AD) effects and so on. |
| S9032 | Sanguinarine | Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation. |
| S9036 | (20R)Ginsenoside Rh2 | (20R)Ginsenoside Rh2, a natural compound found in Panax ginseng, shows antiviral and anticancer activities. It is a matrix metalloproteinase (MMP) inhibitor. |
| S9024 | 3-O-Acetyl-11-keto-β-boswellic acid (AKBA) | 3-O-Acetyl-11-keto-β-boswellic acid (AKBA), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase. |
| S9044 | Ginsenoside F2 | Ginsenoside F2, a ginsenoside found in Panax species, is an autophagic initiater with anti-cancer, and anti-obesity activities. |
| S9042 | Wedelolactone | Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11. |
| S9030 | Tenacissoside I | Tenacissoside I is a natural compound found in M. tenacissima at relatively high level. |
| S5677 | Xanthopterin Hydrate | Xanthopterin, isolated from butterfly wings and found in many other sources, replace folic acid in the nutrition of many animal species. |
| S9353 | L-serine | L-serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation. |
| S9349 | D-(+)-Raffinose pentahydrate | Raffinose is a trisaccharide composed of galactose, glucose, and fructose. |
| S9341 | 3,4-Dimethoxycinnamic acid | 3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM. |
| S9344 | DL-Methionine | DL-Methionine is an amino acid that has a role in the defence of oxidative stress. |
| S9004 | Chondroitin 4-sulfate | Chondroitin 4-sulfate is an important structural component of cartilage and has been used as a dietary supplement to treat symptoms of joint discomfort. |
| S9373 | Neryl acetate | Neryl acetate (Nerol, Acetic acid neryl ester, cis-Geranyl), a chemical compound found in citrus oils, is a flavouring agent. |
| S9339 | S-(-)-Cotinine | S-(-)-Cotinine, a constituent of tobacco products and the major metabolite of nicotine, stimulates nicotinic receptors to evoke the release of DA in a calcium-dependent manner from superfused rat striatal slices. |
| S9372 | Ethyl palmitate | Ethyl palmitate (Ethyl hexadecanoate, Palmitic acid ethyl ester) is a long-chain fatty acid ethyl ester that is used as a hair- and skin-conditioning agent. |
| S4937 | 4'-Hydroxychalcone | 4'-Hydroxychalcone (P-Cinnamoylphenol)，存在于草药、香料和茶叶中，是一种刺甘草查尔酮。它具有多种生物活性，能够抑制TNF-α诱导的NF-κB通路激活、并激活BMP信号通路。 |
| S3622 | Diammonium Glycyrrhizinate | Diammonium glycyrrhizinate (DG)是一种传统的中草药，从甘草中提取纯化而来。它具有抗炎活性，对生物氧化具有抗性、对膜具有保护性。DG通过抑制NF-κB、TNF-α和细胞间黏附分子1来减少炎症损伤。 |
| S3769 | Palmatine | Palmatine (Berbericinine, Burasaine), an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities. |
| S3788 | Carvacrol | Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities. |
| S5176 | Fructose | Fructose (D-(-)-Fructose, Fruit sugar, levulose, fructosteril, D-fructofuranose, D-arabino-hexulose) is a simple ketonic monosaccharide found in many plants. |
| S5178 | 4-Hydroxy-2,5-dimethyl-3(2H)furanone | 4-Hydroxy-2,5-dimethyl-3(2H)furanone (furaneol, HDMF) is a naturally occurring substance found in a variety of fruits and has been shown to have antimicrobial activity. |
| S5592 | Vitamin A | Vitamin A (Retinol) is a naturally occuring fat-soluble vitamin that is important for normal vision, the immune system, and reproduction. It also plays roles in normal functioning of heart, lungs, kidneys, and other organs. |
| S5591 | Ectoine | Ectoine ( THP(B)) is a natural amino acid derivate with membrane stabilizing and inflammation reducing capacities. It is produced by bacteria living under extreme harsh environmental conditions where it serves as osmoregulatory compatible solute. |
| S4888 | Guanine | Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA. |
| S5505 | 2’-deoxyuridine | 2'-deoxyuridine (dU, 2'-dU) is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. |
| S5503 | O-Acetyl-L-carnitine hydrochloride | O-Acetyl-L-carnitine (Acetyl-L-carnitine, O-acetyl-L-carnitine, O-Acetylcarnitine) can be synthesis or is naturally found in healthy humans. It could help transport fatty acids into the mitochondrial matrix where fatty acid metabolism occurs. |
| S9368 | ADP | ADP (Adenosine diphosphate, adenosine pyrophosphate, Adenosine 5'-diphosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells. |
| S5550 | Ethyl gallate | Ethyl gallat (Phyllemblin, gallic acid ethyl ester), which could be found naturally in a variety of plant sources, is a food additive with antimicrobial activity. |
| S9390 | Astragaloside II | Astragaloside II, extracted from Astragalus membranaceus, has been reported to promote tissue wound repair and could be a potential adjunctive agent in cancer chemotherapy, enhancement of osteogenesis, and modulation of T cell activation. |
| S9166 | Griffonilide | Griffonilide is a natural product that has been reported to induce bone remodeling activity resulting in structural changes. |
| S9169 | Polygalasaponin F | |
| S9198 | Obtusifolin | Obtusifolin is anthraquinone found in the seeds of Cassia obtusifolia, has inhibitory effects on platelet aggregation and aldose reductase. |
| S9220 | Stylopine hydrochloride | Stylopine (Tetrahydrocoptisine, Coptisine), a major component of the leaf of Chelidonium majus L., is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity. |
| S9241 | Polygalaxanthone III | Polygalaxanthone III 是一种天然产物，具有镇静，减轻感冒，消除痰液和消肿的功效。Polygalaxanthone III 抑制 CYP2E1 催化的氯唑沙宗6-羟基化反应，IC50值为50.56 μM。 |
| S9259 | Lithospermic acid | Lithospermic acid, an active component isolated from Salvia miltiorrhiza radix, is known to have multiple pharmacological actions such as antihypertensive and antioxidant effects. |
| S9262 | Raddeanin A | Raddeanin A (Raddeanin R3, NSC382873), a triterpenoid saponin from Anemone raddeana Regel, displays moderate inhibitory activity against histone deacetylases (HDACs) and has high antiangiogenic potency, antitumor activity. |
| S9264 | Decursin | Decursin (D), purified from Angelica gigas Nakai, shows potential anti-inflammatory activity and neuroprotective property. |
| S9306 | Corynoxeine | Corynoxeine, which could be isolated from Uncaria rhynchophylla, is a useful and prospective compound in the prevention and treatment for vascular diseases. It is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation. |
| S9310 | Isorhychophylline | Isorhynchophylline (IsoRhy, 7-Isorhyncophylline) is a major tetracyclic oxindole alkaloid isolated from the Chinese herbal medicine Uncaria rhynchophylla (Miq.)Jacks (Gouteng in Chinese). It acts as a neuronal autophagy inducer with therapeutic potential for cardiovascular and central nervous system diseases. |
| S9414 | Cyasterone | Cyasterone is the main phytoecdysteroid component found in Cyathula capitata. It is a natural EGFR inhibitor and maybe a promising anti-cancer agent. |
| S9448 | D-(+)-Turanose | D(+)-Turanose is a naturally occuring compound. It is a reducing disaccharide. |
| S5745 | Glyceryl 1,3-dipalmitate | Glyceryl 1,3-dipalmitate acts as a metabolite of saccharomyces cerevisiae, plant and human. |
| S9507 | (−)-Norepinephrine | (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline)是一种天然存在的神经递质和激素。它是adrenergic receptors的激动剂，对α1, α2A和β1肾上腺素受体的Ki值分别为330 nM、56 nM和740 nM。 |
| S9505 | Oleanonic Acid | Oleanonic Acid (3-Ketooleanolic Acid, 3-Oxooleanolic acid), extracted from Pistacia terebinthus galls, is a cell cycle inhibitor and used as antitumor agents. |
| S5686 | Tryptanthrin | Tryptanthrin is a natural alkaloidal compound having basic indoloquinazoline moiety. It has broad spectrum of biological activities including anticancer activity, anti-inflammatory, antiprotozoal, antiallergic, antioxidant, and antimicrobial. |
| S5690 | Triacanthine | Triacanthine, which could be isolated from the leaves of G. triacanthos, shows hypertensive activity, also cardiotonic, antispasmodic and a respiratory analeptic. |
| S5554 | Lanatoside C | Lanatoside C 是具有抗病毒和抗肿瘤活性的强心苷。Lanatoside C 通过减弱 MAPK，Wnt，JAK-STAT和PI3K/AKT/mTOR信号通路，诱导G2/M细胞周期停滞并诱导自噬和细胞凋亡。 |
| S5312 | Urolithin A | Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption. |
| S3817 | Harmine hydrochloride | Harmine (Telepathine)是属于β-咔啉家族化合物的一种荧光harmala生物碱，是一种高细胞渗透性的 DYRK1A 的激酶口袋结合ATP的竞争性抑制剂，与DYRK2结合IC50值高约60倍。Harmine 还可以抑制 monoamine oxidases (MAOs) 和 cdc-like kinases (CLKs)。Harmine 抑制 5-HT2A serotonin receptor 的Ki值为397 nM。 |
| S5318 | Acacetin | Acacetin (Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin) is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects. |
| S9345 | Disodium 5'-Inosinate | Disodium 5'-Inosinate, widely distributed in all animal and plant tissues, is used as a flavor enhancer. |
| S9059 | 4'-O-Glucosylvitexin | 4'-O-Glucosylvitexin is a kind of flavonoid fraction from the leaves of Crataegus pinnatifida. |
| S9364 | 6-Hydroxycoumarin | 6-Hydroxycoumarin demonstrates cytotoxic effect against the cancer cell lines. |
| S9365 | Disodium uridine-5'-monophosphate | Disodium uridine-5'-monophosphate is a nucleotide that is a major component of ribonucleic acid. |
| S9366 | 5'-Adenylic acid | AMP, also known as 5'-Adenylic acid and Adenosine monophosphate, is a nucleotide that is found in RNA. It is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet. |
| S9369 | Xanthosine | Xanthosine (Xanthine riboside) is an intermediate in purine metabolism, formed from IMP, and forming GMP. |
| S9370 | Adenosine Cyclophosphate | Adenosine Cyclophosphate is useful for improving myocardial hypoxia, dilating coronary artery and strengthening myocardiac contraction. |
| S9384 | Sophocarpine Monohydrate | Sophocarpine, a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities. |
| S9386 | Polygalacic acid | Polygalacic acid 是从远志属植物（Polygala paenea L.）分离出的三萜类四羟酸。Polygalacic acid (0-100μM; 24h) 可以显著降低 MMP-3、MMP-9、MMP-13 和 COX-2 的mRNA表达，这些因子的表达由IL-1β诱导可显著增加，并呈现出剂量依赖性。 |
| S9387 | Maackiain | Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects. |
| S9388 | (+)-Praeruptorin A | Praeruptorin A is a coumarin compound naturally occurring in the roots of Peucedanum praeruptorum Dunn., a commonly used traditional Chinese medicine for the treatment of certain respiratory diseases and hypertension. Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of NF-κB activation. (+)-Praeruptorin A is one of enantiomers. |
| S9389 | Phorbol | Phorbol is a natural, plant-derived organic compound that exerts a broad range of biological activities. |
| S9401 | 3,6'-Disinapoyl sucrose | 3,6'-Disinapoyl sucrose (Disinapoyl sucrose), an oligosaccharide ester natural product originating from the root of wild Polygala tenuifolia, has neuroprotective effects and antidepressive activity in rats. |
| S9400 | Rhynchophylline | Rhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension. |
| S9398 | Crassicauline A | Crassicauline A, a diterpenoid alkaloid in Aconitum herbs, is an analgesic drug clinically used in China. |
| S9397 | Alliin | Alliin (S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine) is a sulfoxide that is a natural constituent of fresh garlic. |
| S9396 | Geraniin | Geraniin, a hydrolysable polyphenol derived from Nephelium lappaceum L. fruit rind, has been shown to possess significant antioxidant activity in vitro. |
| S9392 | Praeruptorin B | Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities. |
| S9402 | (20R)-Protopanaxadiol | (20R)-Protopanaxadiol, isolated from the roots of Panax ginseng, has protective effect on myocardial ischemia. |
| S9404 | Pristimerin | Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. |
| S9405 | Sesamoside | Sesamoside, a main chemical ingredient iridoid glycoside from Lamiophlomic rotata, has analgesic and anti-inflammatory effects in animal studies. |
| S9406 | Sauchinone | Sauchinone, one of the active lignan isolated from the roots of Saururus chinensis, possesses diverse pharmacological properties, such as hepatoprotective, anti-inflammatory and anti-tumor effects. |
| S9407 | Angoroside C | Angoroside C, an important phenylpropanoid glycoside of the traditional Chinese medicine Scrophulariae Radix, possesses the effects of preventing ventricular remodeling, reducing pulmonary oedema, and reducing blood pressure, as well as having the properties of anti-platelet aggregation, hepatoprotection and anti-nephritis, etc. |
| S9408 | Beta-Elemonic acid | Beta-Elemonic acid (3-Oxotirucallenoic Acid), a known triterpene isolated from Boswellia (Burseraceae), exhibits anti‑inflammatory effects. |
| S9409 | Kavain | Kavain, the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. |
| S9410 | Euphorbia factor L1 | Euphorbia factor L1, a diterpenoid isolated from Euphorbia lathyris, inhibits osteoclastogenesis and induces osteoclast apoptosis. |
| S9411 | Liensinine | Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities. |
| S9412 | Flavokawain B | Flavokawain B is a natural chalcone first isolated from extracts of kava roots that induces apoptosis in cancer cells. |
| S9413 | Yangonin | Yangonin (Y100550) is a dienolide kavalactone originally found in Piper methysticum (kava plant) and exhibits neuroprotective, neuromodulatory, and antifungal activities. It activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors. |
| S9416 | Triptonide | Triptonide, isolated from the roots of Tripterygium wilfordii, can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. It is also an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent. |
| S9417 | Homoplantaginin | Homoplantaginin (Hispidulin-7-glucoside) 是中草药丹参中的主要类黄酮，具有抗炎和抗氧化作用。Homoplantaginin 可抑制 TNF-α 和 IL-6 mRNA 表达，IKKβ 和 NF-κB 磷酸化。 |
| S9420 | Sinoacutine | Sinoacutine (Salutaridine), isolated from the Chinese drug Ching-fengteng, elicits mild antitussive properties. |
| S9421 | Demethylnobiletin | Demethylnobiletin (5-Demethylnobiletin)是一种在柑橘类水果中发现的独特的类黄酮，具有潜在的化学预防人类癌症的作用。5-Demethylnobiletinin 是 5-LOX 的直接抑制剂，IC50值为0.1 μM，且不影响COX-2的表达。5-Demethylnobiletinin 具有抗炎活性，可抑制大鼠中性粒细胞中 leukotriene B 4(LTB4) 的形成和人中性粒细胞中elastase弹性蛋白酶 (elastase) 的释放，IC50为0.35 μM。 |
| S9422 | Diosbulbin B | Diosbulbin B is the main hepatotoxic compound in Airpotato yam, which is traditionally used for treating thyroid disease and cancer. |
| S9423 | Narcissoside | |
| S9425 | Trifolirhizin | Trifolirhizin, a natural pterocarcan flavonoid extracted from Sophora flavescens, has many pharmacological activities, such as hepatoprotective, anti-inflammatory, anti-proliferation, and skin-whitening. |
| S9427 | Tabersonine | Tabersonine is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus and shows hypotensive activity, anti-tumor activity, hypoglycemic, diuretic activity. |
| S9428 | Brazilin | Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties. |
| S9429 | 6α-Hydroxygeniposide | 6α-Hydroxygeniposide, an iridoid glycoside, is a chemical constituents of Pittosporum glabratum Lindl. |
| S9430 | Tomatidine | Tomatidine, a natural steroidal alkaloid, possesses potent antibacterial activity and has anti-inflammatory effects in macrophages. |
| S9431 | Dehydrocorydalin | Dehydrocorydalin is an alkaloidal component isolated from Rhizoma corydalis. It has anti-inflammatory and anti-tumor effects and can protect the cardiovascular system. |
| S9433 | Tubeimoside II | Tubeimoside II (Tubeimoside B), a natural triterpenoid saponin isolated from herb, show anti-inflammatory, antitumor, and antitumor-promoting effects. |
| S9434 | 8-Gingerol | 8-Gingerol is a bioactive ingredient of ginger root (Zingiber officinale), a medicinal plant having anti-nausea, anti-inflammatory, and anti-carcinogenic properties and a carminative effect. |
| S9435 | Secoxyloganin | Secoxyloganin is a secoiridoids that is extensively used in synthetic and biosynthetic studies of monoterpene indole alkaloids and related natural products. |
| S9436 | Pinoresinol dimethyl ether | Pinoresinol dimethyl ether, which could be isolated from the wood of the basal tree Humbertieae, show a variety of activities as the inhibitor of cyclic AMP phosphodiesterase. |
| S9437 | Echinatin | Echinatin is a licorice extract that displays antioxidant properties and anti-inflammatory activities. |
| S9438 | Isosakuranetin | Isosakuranetin (4'-Methylnaringenin), an O-methylated flavonoid, is the 4'-methoxy derivative of naringenin, a flavanone found in Citrus species. |
| S9120 | Scutellarein | Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities. |
| S9439 | Kaurenoic acid | Kaurenoic acid (kaurenoate, kaur-16-en-18-oic acid) is a natural diterpenoid found in the herbs of Croton antisyphiliticus. Kaurenoic acid has anti-inflammatory activity, the mechanisms may through inhibition of iNOS and COX-2 expression. |
| S9441 | Sibiricose A5 | Sibiricose A5, which could be isolated from traditional Chinese medicine Polygalae Radix, shows potent antioxidant activity. |
| S9442 | Bergaptol | Bergaptol (5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin)是在柠檬、佛手柑等柑橘精油中发现的天然呋喃香豆素。Bergaptol 是有效的 CYP3A4 酶脱苄基活性抑制剂，IC50值为24.92 μM。 |
| S9443 | Schisantherin B | Schisantherin B is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine. |
| S9444 | Tomatine | Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties. |
| S9446 | Dihydrokavain | Dihydrokavain (Marindinin) is a kavalactone source from kava beverages used in herbal medicine to treat sleep disturbances, as well as stress and anxiety. |
| S9447 | 1F-Fructofuranosylnystose | 1F-Fructofuranosylnystose is a kind of Fructooligosaccharides which are naturally occurring sugars with potentially beneficial nutritional effects. |
| S9503 | Fraxetin | Fraxetin (7,8-dihydroxy-6-methoxy coumarin), found in Fraxinus rhynchophylla, shows potent antioxidant activity. |
| S9502 | Madecassic acid | Madecassic acid (Brahmic acid) 是最早从积雪草中分离的天然三萜，具有多种消炎和抗糖尿病作用，阻断巨噬细胞中的 NF-κB 活化并导致 iNOS、COX-2、TNF-alpha、IL-1beta 和 IL-6 抑制。 |
| S9001 | Malic acid | Malic acid (Hydroxybutanedioic acid, 2-Hydroxysuccinic acid) is a common, naturally occurring ingredient in many foods. It is the main acid found in apples and other fruits. |
| S9002 | L-Fucose | Fucose (6-Deoxy-L-Galactose, L-fucopyranose) is found on N-linked glycans on the mammalian, insect and plant cell surface. L-Fucose is claimed to have application in cosmetics, pharmaceuticals, and dietary supplements. |
| S9006 | Perillartine | Perillartine (Perilla sugar, Peryllartine) is a sweetener. |
| S9014 | AstragalosideⅠ | AstragalosideⅠ, is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. |
| S5083 | Lentinan | Lentinan (A823605, Bromoduline)，分离纯化自香菇子实体水煮提取物，是一种真菌多糖免疫调制剂，具有抗肿瘤活性。 |
| S9272 | Koumine | Koumine, a Gelsemium alkaloid, possesses analgesic, anti-inflammatory and neurosteroid modulating activities. |
| S9273 | Timosaponin BII | Timosaponin BII (BII, Prototimosaponin AIII) is a steroidal saponin showing potential anti-dementia and antioxidant activity. |
| S9274 | Isochlorogenic acid B | Isochlorogenic acid B, naturally isolated from Laggera alata, has antioxidative and hepatoprotective properties. |
| S9275 | Isoguanosine | Isoguanosine (Crotonoside)抑制 FLT3 和 HDAC3/6 治疗AML。Isoguanosine 是巴豆（Croton tiglium）种子中天然存在的鸟苷的活性异构体。 |
| S9276 | Alisol B | Alisol B, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways. |
| S9277 | Alisol A | Alisol A is one of the major active triterpenes isolated from Rhizoma Alismatis (RA), a famous Traditional Chinese Medicine widely used for diuretic, hypolipidemic, anti-nephrolithic, anti-atherosclerotic, anti-inflammatory and anti-diabetic purposes. |
| S9278 | Saikosaponin C | Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities. |
| S9279 | Euphorbia factor L3 | Euphorbia factor L3 (5,15-Diacetyl-3-benzoyllathyrol), belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed, shows potent cytotoxicity and induces apoptosis via the mitochondrial pathway in A549 cells. |
| S9280 | Demethoxycurcumin | Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties. |
| S9281 | Peimine | Peimine (Verticine, Wanpeinine A) is a major biologically active component of Fritillaria ussuriensis, exhibits anti-inflammatory and pain suppression properties at the cellular level. |
| S9267 | Epimedin A | Epimedin A is a major component of Herba Epimedii with bioactivities. |
| S9268 | Epmedin B | Epmedin B (Epimedin B) is a component extracted from Epimedii Folium and may have antiosteoporotic activity. |
| S9269 | Epmedin C | Epmedin C (Epimedin C, Baohuoside VI), a flavonoid isolated from the herbs of Epimedium brevicornum Maxim, exhibits immunostimulatory and anticancer activities. |
| S9270 | Dracohodin perochlorate | Dracohodin perochlorate, extracted from Dragon's blood, is widely used in traditional Chinese medicine, especially in wound healing. |
| S9271 | Pulchinenoside A | Pulchinenoside A (Anemoside A3), a natural triterpenoid saponin, is a AMPARs and NMDAR modulator. |
| S9282 | Isochlorogenic acid A | Isochlorogenic acid A (3,5-dicaffeoylquinic acid), isolated from Brazilian propolis and Suaeda glauca, exhibits hepatoprotective and cytotoxic activities. |
| S9283 | Aristolone | Aristolone, which could be extracted from essential oil of Elyonurus hensii, is likely to induce an antalgic activity. |
| S9284 | Aloesin | Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro. |
| S9285 | Fargesin | Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway. |
| S9286 | Neobavaisoflavone | Neobavaisoflavone, isolated from seeds of Psoralea corylifolia, exhibits inhibitory activity against DNA polymerase and platelet aggregation. |
| S9287 | Genkwanin | Genkwanin (Apigenin 7-methyl ether) is one of the major non-glycosylated flavonoids in herbs. It has a variety of pharmacological effects including anti-inflammatory, anti-bacterial, antiplasmodial, radical scavenging, chemopreventive and inhibiting 17β-Hydroxysteroid dehydrogenase type 1 activities. |
| S9288 | Casticin | Casticin (Vitexicarpin), as the major active substance in Lithospermum erythrorhyzon, had been reported to mediate multiple pharmacological activities such as antioxidation, antiviral, cardiovascular protection, antineoplastic and anti-inflammation. |
| S9289 | Astragalin | Astragalin (kaempferol-3-glucoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside), a flavonoid from leaves of persimmon and green tea seeds, has anti-tumor, anti-inflammatory and anti-oxidant activities. |
| S9290 | Linarin | Linarin (Acaciin, Buddleoside, Acacetin-7-O-rutinoside), a natural flavonoid cpompound, has pharmacological effects, including anti-inflammatory, neuro-protective, cardioprotective and antioxidative effects. |
| S9291 | Isopimpinellin | Isopimpinellin (5,8-Dimethoxypsoralen) is a natural product synthesized by numerous plant species. It may acts as an anticarcinogen. |
| S9292 | Dictamnine | Dictamnine, a natural plant product, has been reported to have antimicrobial activity against bacteria and fungi. |
| S9293 | Isoliquiritin | Isoliquiritin (Neoisoliquritin) is a flavonoid glycoside compound from licorice possessing a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory, and anti-depression activities. |
| S9294 | Gelsemine | Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., is a highly toxic compound and may be a glycine receptor agonist with significantly higher binding affinity for some of these receptors than its native agonist, glycine. |
| S9295 | Dauricine | Dauricine, a plant metabolite isolated from the Asian vine Menispermum dauricum, plays a variety of biological roles in the human body, from inhibiting cancer cell growth to blocking cardiac transmembrane Na+, K+, and Ca2+ ion currents.Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF‐κB signaling pathway in colon cancer cells. |
| S9296 | Fraxin | Fraxin (Fraxetin-8-O-glucoside), a main active component isolated from Cortex Fraxini, possesses a variety of bioactivities such as anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, immunomodulatory, anti-hyperuricemia and diuresis. |
| S9297 | Kirenol | Kirenol is a biologically active substance isolated from Herba Siegesbeckiae. It has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities. |
| S9298 | Corylin | Corylin, a main compound isolated from Psoralea corylifolia L. (Fabaceae), has a variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties. |
| S9300 | Methylprotodioscin | Methyl protodioscin, a bioactive natural compound isolated from Dioscorea collettii Makino (Dioscoreaceae), has numerous pharmacological activities, including anti-inflammation, lipid-lowering, and anticancer activities. |
| S9301 | Verbenalin | Verbenalin (Verbenalol β-D-glucopyranoside, Verbenalol glucoside, Cornin), an iridoid glycoside found in Verbena officinalis, has been reported to exhibit uterine stimulant activity and demonstrated cardioprotection against experimental myocardial ischemic injury. |
| S9302 | Polyphyllin VI | Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities. |
| S9303 | Saikosaponin B2 | Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry. |
| S9304 | Platycodin D | Platycodin D, the main saponin isolated from Chinese herb Platycodonis Radix, exhibits anti-inflammatory, anti-allergic, cholesterol-lowering and neuroprotective properties. |
| S9305 | Toosendanin | Toosendanin, a triterpenoid extracted from Melia toosendan Sieb et Zucc, possesses broad biological actions from blocking neurotransmission and antibotulism to inducing cell differentiation and apoptosis. |
| S9307 | Shanzhiside methyl ester | Shanzhiside methylester is a principle effective iridoid glycoside of L. rotata and serves as a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist. |
| S9308 | Pulsatilla saponin D | Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla koreana, targets c-Met and exerts antiangiogenic and antitumor activities. |
| S9309 | Micheliolide | Micheliolide, a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, inhibits various inflammatory response and may serve as a neuroprotective agent in neuroinflammation-related neurodegenerative disorders. |
| S9311 | Germacrone | Germacrone, a major activity component found in Curcuma zedoaria oil product, shows anti-inflammatory, antiandrogenic, and antimicrobial activities. |
| S9312 | Cyanidin-3-O-glucoside chloride | Cyanidin-3-O-glucoside chloride (Kuromanin, Chrysontemin, Glucocyanidin) is a natural product with anti-oxidant and neuroprotective effects. |
| S9313 | Atractylenolide III | Atractylenolide III, a major component of Atractylodes rhizome, has anti-inflammatory and anti-angiogenesis activities. |
| S9314 | Atractylenolide II | Atractylenolide II (AT-II, Asterolide, 2-Atractylenolide), a major sesquiterpenoids isolated from the dried Rhizome of Atractylodes macrocephala, shows a wide range of biological and pharmacological activities, for example, against insomnia and anxiety, neuroprotective, platelet activation and anti-cancer effect. |
| S9315 | Praeruptorin A | Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. Praeruptorin A inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Praeruptorin A can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction. |
| S9316 | Polyphyllin II | Polyphyllin II, a natural compound extracted from Rhizoma of Paris polyphyllin, shows hemolytic activity. |
| S9317 | Forsythoside A | Forsythoside A, one of the main active ingredients in Forsythiae fructus, has been shown to possess anti-bacterial and immunomodulatory properties. |
| S9318 | (20R)-Ginsenoside Rh1 | (20R)-Ginsenoside Rh1, isolated from the root of Panax Ginseng, exhibits various pharmacological activities including vasorelaxation, antioxidation, anti-inflammation, and anticancer. |
| S9319 | Cryptochlorogenic acid | Cryptochlorogenic acid (4-Caffeoylquinic acid, 4-O-Caffeoylquinic acid), a phenolic acid found in various plant species, including Artemisia, honeysuckle, and H. sabdariffa, possesses antioxidant properties. |
| S9322 | Neodiosmin | |
| S9324 | Alnustone | Alnustone, a naturally occuring compound found in the rhizomes of Curcuma xanthorrhiza, exhibits anti-inflammatory, antihepatotoxic and antiemetic activities. |
| S9329 | Orcinol | Orcinol (5-Methylresorcinol; 3,5-ToluenediolOrcin; 5-Methyl-1,3-benzenediol; 3,5-Dihydroxytoluene), occurs in many species of lichens including Roccella tinctoria and Lecanora, exhibits antimutagenic, antioxidant, antibacterial, radical-scavenging effects. |
| S9343 | Sequoyitol | Sequoia alcohol (Sequoyitol) is isolated from Taxus natural organic compounds, it can be used to treat diabetes and other indications. |
| S9347 | Allitol | Allitol (Allodulcitol) is a rare polyol found in nature that is useful not only as a sweetener, but also as the raw material for production of chemical compounds. |
| S9348 | D-(+)-Trehalose Anhydrous | Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration. |
| S9350 | Ethyl 4-Methoxycinnamate | Ethyl 4-Methoxycinnamate (Ethyl p-methoxycinnamate, 4-Methoxycinnamic Acid Ethyl Ester), a natural product found in K. galanga and C. zedoaria extracts, has anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities. |
| S9354 | Oxalic acid | Oxalic acid (Ethanedioic acid, Wood bleach) is a strong dicarboxylic acid occurring in many plants and vegetables. |
| S5636 | Methyl furan-2-carboxylate | Methyl furan-2-carboxylate (Methyl pyromucate, Methyl 2-furoate) is found in cocoa and cocoa products. It is used in food flavouring and preparation of sesquiterpene lactone. |
| S3814 | Tubeimoside I | Tubeimoside I (Lobatoside H, TBMS1), a triterpenoid saponin, isolated from the tubers of Bolbostemma paniculatum, shows potent antitumor and antitumor-promoting effects. |
| S8068 | Chaetocin | Chaetocin，一类来自毛壳菌属的天然产物，是一类 histone methyltransferase 抑制剂，其对dSU(VAR)3-9，小鼠G9a和粗糙链孢霉 DIM5的IC50分别为0.8 μM, 2.5 μM和3 μM。Chaetocin是一种抗癌药物并是 thioredoxin reductase (TrxR) 的抑制剂。 |
| S3790 | Methyl gallate | Methyl Gallate (Methylgallate, Gallic acid methyl ester, Gallicin) is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities. |
| S4800 | Daminozide | Daminozide (Aminozide, DMASA, DIMG, B 995, Alar，Kylar，B-NINE, SADH), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily with IC50 of 1.5±0.7 μM for KDM2A. It is at least 100-fold selective as an inhibitor of the KDM2/7 subfamily over the other demethylase subfamily members tested, with IC50s of 2 μM or less against KDM2A, PHF8, and KIAA1718 and IC50s of 127 μM for KDM3A or greater (mM range) against other demethylases. |
| S9188 | Magnoflorine chloride | Magnoflorine (Escholine, Thalictrine, Corytuberine methochloride), isolated from the rhizome of Sinomenium acutum and from Pachygone ovata, is usually used as an anxiolytic chemical with anti-oxidant, α-tyrosinase inhibitory and anti-inflammationary activities. |
| S9189 | Oroxin A | Oroxin A (Baicalein 7-O-glucoside), an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ and inhibits α-glucosidase, exerting antioxidant activity. |
| S9190 | Oroxin B | Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment. |
| S9191 | Loganic acid | Loganic acid (Loganate) is a naturally occurring iridoid monoterpeneglusoside involved in the biosynthesis of indole alkaloids in Vinca rosea. |
| S9194 | Toddalolactone | Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM. |
| S9195 | Maltotetraose | Maltotetraose, found in many foods, belongs to the class of organic compounds known as oligosaccharides. |
| S9196 | Calceolarioside B | Calceolarioside B (Nuomioside A), found in the herbs of Ajuga becumbens Thunb., has anti-proliferation property. |
| S9199 | Pseudoginsenoside F11 | Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist. |
| S9200 | Pneumocandin B0 | Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent. |
| S9203 | Notopterol | Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities. |
| S9204 | Oroxylin A | Oroxylin A (6-Methoxybaicalein) is a flavonoid isolated from Scutellaria root that exhibits multiple pharmacological activities, including anti-oxidative, anti-inflammatory, anti-viral and anti-tumor properties. |
| S9205 | Hydroxygenkwanin | Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, has anti-oxidant ability and can act as tissue factor (TF) inhibitor to prevent thrombosis. |
| S9206 | Hydroprotopine | Hydroprotopine (W1171) is a kind of natural herbal extract. |
| S9514 | Rotundic acid | Rotundic acid (Rutundic acid)是一种天然化合物，对人肝细胞癌（HepG2）、恶性黑色素瘤（A375）、SCLC（NCI-H446）、乳腺癌（MCF-7）和结肠癌（HT-29）细胞系表现出细胞毒活性。Rotundic acid 通过调节 AKT/mTOR and MAPK pathways 诱导细胞周期停滞、DNA损伤和细胞凋亡。 |
| S9207 | Gypenoside XVII | Gypenoside XVII (GP-17, Gynosaponin S), a ginsenoside found in Panax species, has neuroprotective effects and is widely used to prevent cardiovascular disease. |
| S9208 | Ginsenoside Rb3 | Ginsenoside Rb3 是从人参中提取的天然产物，在心血管疾病包括心肌的缺血/再灌注(I/R)损伤中起着重要作用。在人肾293T细胞中检测了Ginsenoside Rb3(0.1-10 μM)对肿瘤坏死因子TNF-α诱导的 nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) 荧光素酶报告基因的抑制作用，IC50值为8.2 μM。在用10 ng/mL TNF-α处理后的HepG2细胞中，Ginsenoside Rb3 还以剂量依赖性的方式抑制 cyclooxygenase-2 (COX-2) 和 inducible nitric oxide synthase (iNOS) 信使mRNA的诱导诱导表达。 |
| S9209 | Tritetradecanoin | Tritetradecanoin, found in Myristica fragrans Houtt., is used as an antiadhesion agent and lubricating agent. |
| S9210 | Ginsenoside Rk1 | Ginsenoside Rk1, one of the main elements of Sung Ginseng, has been confirmed as a new endothelial barrier enhancer recently and has anti-cancer activity. |
| S9211 | Eriocitrin | Eriocitrin (eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside) is a flavone glycoside mainly found in lemon with antioxidant activity. |
| S9213 | Jujuboside A | Jujuboside A, isolated from Semen Ziziphi Spinosae, exerts anti-oxidant, anti-inflammatory activities, and reduces the cell apoptosis. |
| S9214 | Jujuboside B | Jujuboside B, one of the saponins isolated from the seeds of Zizyphus jujuba var. spinosa, is used in traditional chinese medicine for treating cardiovascular diseases and neurodegenerative diseases. |
| S9215 | Pinoresinol diglucoside | Pinoresinol diglucoside, one of the major lignans isolated from Eucommia ulmoides Oliver bark, has various pharmacological functions, including antihypertension and prevention of osteoporosis. |
| S9216 | Esculentoside A | Esculentoside A, isolated from the Chinese herb phytolacca esculenta, possesses a broad inhibitory effect on a panel of pro-inflammation molecules with less toxicity. |
| S9217 | Complanatuside | Complanatuside, a flavonoid compound isolated from Astragalus complanatus and Lysimachia christinae, has anti-inflammation, lipid-lowering and hepatoprotective effects. |
| S9219 | Huperzine B | Huperzine B, a natural alkaloid existed in Lycopodium plants, is a novel acetylcholinesterase inhibitor and has neuroprotective effects. |
| S9221 | Ferulaldehyde | Ferulaldehyde (Coniferaldehyde, Ferulyl aldehyde) is a natural intermediate of polyphenol metabolism of intestinal microflora. |
| S9222 | Dipotassium glycyrrhizinate | Dipotassium glycyrrhizinate (Neubormitin) 是从甘草根中分离出来的一种广泛使用的抗炎药。 |
| S9223 | Talatisamine | Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities. |
| S9224 | Dehydroandrographolide Succinate | Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects. |
| S9226 | Steviolbioside | Steviolbioside (CCRIS-6025), a natural sweetener, exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro. |
| S9228 | Schisandrin C | Schisandrin C, a dibenzocyclooctadiene lignan isolated from the fruits of Schisandra chinensis (Turcz.) Baill, has many characteristics including anti-inflammation, anti-tumor, and anti-oxidation. |
| S9229 | Linderane | Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache. |
| S9230 | Vaccarin | Vaccarin, a major flavonoid glycoside found in Semen vaccariae, exhibits extensive biological activities including vascular endothelial cell protective effects. |
| S9231 | Schisanhenol | Schisanhenol (Gomisin K3) is a compound derived from the fruit of a traditional Chinese herb Schisandra rubriflora, exhibiting strong inhibition toward UGT2B7. |
| S9232 | Crocin II | Crocin II (Crocin B, Crocetin gentiobiosylglucosyl ester, Tricrocin), a carotenoid chemical compound that is found in the flowers crocus and gardenia, is an antioxidant and neural protective agent. |
| S9233 | Imperialine | Imperialine (Sipeimine, Kashmirine) is an alkaloid found in the bulbs of species of the genus Fritillaria. |
| S9234 | Schaftoside | Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission. |
| S9235 | Didymin | Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties. |
| S9237 | Berberrubine | Berberrubine (Beroline, 9-Berberoline), an isoquinoline alkaloid isolated from many medicinal plants, possesses diverse pharmacological activities, including glucose-lowering, lipid-lowering, anti-inflammatory, and anti-tumor effects. |
| S9238 | Polygalic acid | Polygalic acid (Senegenic acid), a triterpenoid saponin, shows expectorant, emetic and stimulant effects. |
| S9239 | Isocorynoxeine | Isocorynoxeine (7-Isocorynoxeine)是一种在钩藤(Uncaria rhynchophylla)中发现的主要生物碱，对心、脑血管系统具有广泛的有益作用。Isocorynoxeine 可抑制 5-HT2A receptor 介导的电流反应，IC50值为72.4 μM。 |
| S9240 | Isofraxidin | Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent. |
| S9242 | Narirutin | Narirutin (Naringenin-7-O-rutinoside, Isonaringin), a flavanone abundant in citrus fruits, possesses anti-inflammatory and anti-oxidative effects. |
| S9243 | Protosappanin B | Protosappanin B (FT-0689654, Q-100961), extracted from Lignum Sappan, possesses anti-inflammation and anti-oxidation properties. |
| S9244 | 8-O-acetyl shanzhiside methyl ester | 8-O-acetyl shanzhiside methyl ester (Barlerin, ND01), isolated from the leaves of Lamiophlomis rotata Kudo, promotes angiogenesis, which leads to the improvement of functional outcome after stroke.8-O-Acetyl shanzhiside methyl ester can inhibts NF-κB. |
| S9245 | Phellodendrine chloride | Phellodendrine chloride, isolated from the Phellodrndron amurensis, exhibits immunosuppressive and anti-inflammatory activities. |
| S9246 | Tiliroside | Tiliroside, a glycosidic flavonoid, possesses anti-inflammatory, antioxidant, anticarcinogenic and hepatoprotective activities. |
| S9247 | Isoliensinine | Isoliensinine is an alkaloid produced by the edible plant Nelumbo nucifera. It possesses anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities. |
| S9248 | Homoorientin | Homoorientin (Isoorientin, Luteolin-6-C-glucoside) is a flavone that acts as a radical scavenger and an antineoplastic agent. |
| S9249 | Securinine | Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist. |
| S9250 | Isosilybin | Isosilybin (Silymarin, Silybin B, Isosilybinin, Q-100795)是一种在水飞蓟(S. marianum)果实提取物中发现的黄烷醇，具有抗氧化和抗癌活性。Isosilybin 抑制 CYP3A4 诱导，IC50为74 μM。 |
| S9251 | Oxypeucedanin | Oxypeucedanin is a major coumarin aglycone that can be extracted from Ostericum koreanum. It is a kind of open-channel blocker of the hKv1.5 channel. |
| S9252 | Corydaline | Corydaline is a bioactive alkaloid with various anti-acetylcholinesterase, anti-allergic, and anti-nociceptive activities found in the medicinal herb Corydalis Tubers. |
| S9253 | Coixol | Coixol (6-methoxybenzoxazolone, MBOA) acts as a central muscle relaxant with an anti-convulsant effect. |
| S9254 | Skimmin | Skimmin is one of the major pharmacologically active molecules present in Hydrangea paniculata, a medical herb used in the traditional Chinese medicine as an anti-inflammatory agent. |
| S9255 | Isoscopoletin | Isoscopoletin (7-Methoxyesculetin) is a member of the class of compounds known as hydroxycoumarins. Isoscopoletin can be found in coriander and eggplant, which makes isoscopoletin a potential biomarker for the consumption of these food products. |
| S9256 | Isobavachin | Isobavachin is a flavonoid compound obtained from Psoralea Corylifolia Linn. |
| S9257 | Acetylshikonin | Acetylshikonin is a biologically active compound with anti-cancer and anti-inflammatory activity, which is isolated from the roots of Lithospermum erythrorhizoma. It is a novel general P450 inhibitor with IC50 values of 1.4-4.0 μM for all tested P450s. |
| S9258 | (+)-Isocorynoline | Isocorynoxeine, a major bioactive tetracyclic oxindole alkaloids found in Uncaria rhynchophylla, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM and shows various beneficial effects, including lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. |
| S9260 | Nodakenin | Nodakenin ((+)-Marmesinin), a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM. |
| S9265 | 7-Epitaxol | 7-Epitaxol (7-Epipaclitaxel) is the major derivative of taxol found in cells. Taxol (paclitaxel) is a well-known natural-source cancer drug. |
| S9266 | Ginsenoside Rc | Ginsenoside Rc, isolated from Panax ginseng, may exert various activities including anti-cancer, anti-inflammatory, antiobesity, and anti-diabetic effects. |
| S9186 | Liensinine perchlorate | Liensinine is the active constituent of plumula nelambinis with anti-hypertension. |
| S9187 | Phillygenin | Phillygenin (Sylvatesmin), a bioactive intergradient in Osmanthus fragrans, has anti-inflammatory, anti-obesity and antipyretic activities. It could reduce blood lipid levels and low density lipoprotein. |
| S9517 | Liriope muscari baily saponins C | Liriope muscari baily saponins C, extracted from the roots of Liriope muscari (Decne.) Baily, induces autophagy and has an anti-thrombotic activity. |
| S9201 | Levistilide A | Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer. |
| S9512 | 1,3-Dicaffeoylquinic acid | 1,3-Dicaffeoylquinic acid (Cynarin; Cinarine; 1,5-Dicaffeoylquinic acid) is a phenolic compound found in artichoke. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent. |
| S9114 | Polyphyllin I | Polyphyllin I 是从巴黎茶树素中提取的小分子单体，用于治疗传染病和癌症。 Polyphyllin I 抑制U251细胞增殖并诱导其凋亡。 Polyphyllin I 是 JNK 信号传导途径的激活剂，具有潜在的抗神经胶质瘤作用。 |
| S9115 | Wogonoside | Wogonoside (Oroxindin, Wogonin 7-O-glucuronide, Glychionide B), the main flavonoid component derived from the root of Scutellaria baicalensis Georgi, displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. |
| S9116 | Chikusetsusaponin IVa | Chikusetsusaponin IVa (Calenduloside F) 是三萜类皂苷的主要活性成分，具有多种药理活性，包括对各种癌细胞的细胞毒活性，抗炎活性，预防龋齿和诱导人五味子霉素肾毒性。Chikusetsusaponin IVa 也是一种新型的 AMPK 激活剂。 |
| S9117 | (20S)Ginsenoside Rg2 | (20S)Ginsenoside Rg2, a constituent existing in red ginseng, has been reported to exert strong inhibitory action on various cancer cells. |
| S9119 | Leonuride | Leonuride (Ajugol), an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri, is a terpene glycoside that can be used for some gynecological disease. |
| S9121 | Irigenin | Irigenin, an O-methylated isoflavone, can be isolated from the rhizomes of the leopard lily (Belamcanda chinensis), and Iris kemaonensis. |
| S9122 | Tectorigenin | |
| S9123 | Eriodictyol | Eriodictyol, a flavonoid extracted from yerba santa, has anti-inflammatory and antioxidant activities and taste-modifying properties. |
| S9125 | Apigetrin | Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties. |
| S9126 | Schizandrol B | Schizandrol B (Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin), extracted from the fruit of Schisandra chinensis Baill., exhibits potent antitumor activities. |
| S9127 | Carnosol | Carnosol is a naturally occurring phenolic diterpene found in rosemary. It has anti-oxidant, anti-inflammatory and anti-cancer activities. |
| S9128 | Isoacteoside | Isoacteoside, a phenylethanoid isolated from Monochasma savatieri Franch. ex Maxim., is an anti‐inflammatory herb widely used in traditional Chinese medicine. |
| S9129 | 20(S)-Ginsenoside Rh1 | 20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1)是从红参中提取的主要生物活性化合物之一，在世界范围内，红参已越来越多地用于增强认知和身体健康。它具有抗发炎、抗氧化、免疫调节作用和对神经系统有积极作用的有效特性。20(S)-Ginsenoside Rh1 可抑制 PPAR-γ、TNF-α、IL-6 和 IL-1β 的表达。 |
| S9130 | Rubusoside | Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties. |
| S9131 | Punicalagin | Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects. |
| S9132 | Harpagide | Harpagide, isolated from the secondary roots of Harpagophytum procumbens (Hp), has valuable medicinal properties, such as anti-inflammatory, analgesic and potential antirheumatic effects. |
| S9133 | Chicoric acid | Chicoric acid (Dicaffeoyltartaric acid), identified in many plants, exerts various properties include anti-cancer, anti-obesity, antiviral, and anti-diabetic effects. |
| S9134 | Spinosin | Spinosin (Flavoayamenin), a flavone-C-glycoside, is a bioactive ingredient isolated from a traditional Chinese herb Zizyphi Spinosi Semen. It acts as a plant metabolite and an anxiolytic drug. |
| S9135 | Artemisic acid | Artemisic acid (Artemisinic acid), an amorphane sesquiterpene isolated from Artemisia annua L., has a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect. |
| S9136 | Neochlorogenic acid | Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia. |
| S9137 | Erianin | Erianin, a natural product derived from Dendrobium chrysotoxum, has been used as an analgesic in traditional Chinese medicine and is a potential anti-tumor agent. Erianin can inhibit IDO-induced tumor angiogenesis. |
| S9138 | Picfeltarraenin IA | Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system. |
| S9141 | Berbamine | Berbamine (BA, BBM) 是一种从中草药黄芦木中分离而来的双苄基异喹啉类天然产物。它是bcr/abl的新型抑制剂，具有有效的抗白血病活性，是NF-κB的抑制剂。Berbamine (BA, BBM) 通过靶向 Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) 抑制癌细胞的生长，并诱导人骨髓瘤细胞凋亡。 |
| S9143 | Ammonium Glycyrrhizate | Ammonium glycyrrhizate (Glycamil, Glycyrram) is an ammonium salt extract isolated from licorice root and is commonly used as a flavoring agent and is also used in fragrances, and skin and hair care products. |
| S9144 | Solasonine | Solasonine, a natural glycoalkaloid compound, has anti-inflammation and anti-tumor properties. |
| S9145 | Solamargine | Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition. |
| S9146 | Anwuligan | Anwuligan (Macelignan), a natural compound isolated from Myristica fragrans Houtt, has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities. |
| S9148 | Peiminine | Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth. |
| S9149 | Benzoylpaeoniflorin | Benzoylpaeoniflorin, a natural product isolated from Chinese paeony root, could inhibit COX-1 and COX-2 in vitro. |
| S9150 | Daurisoline | Daurisoline, a bis-benzylisoquinoline alkaloid isolated from the rhizomes of Menispermum dauricum, is a potent autophagy blockers with antiarrhythmic effects. |
| S9151 | Praeruptorin E | Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect. |
| S9152 | Epiberberine | Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean). |
| S9153 | Betulinicaldehyde | Betulinicaldehyde (Betulinal, Betunal), isolated from the bark of tectona grandis., is an anti-tumor agent. |
| S9154 | Chelidonine | Chelidonine (Stylophorin, Helidonine), a major bioactive, isoquinoline alkaloid ingredient in Chelidonium majus, exhibits anti-inflammatory properties and acetylcholinesterase and butyrylcholinesterase inhibitory activity. |
| S9155 | Aurantio-obtusin | Aurantio-obtusin is a natural effective compound isolated from Semen Cassiae, which possesses hypotensive and hypolipidemic effects. |
| S9156 | Chonglou Saponin VII | Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway. |
| S9157 | Neoandrographolide | Neoandrographolide, a principle diterpenoids isolated from A. paniculata, exerts a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities. |
| S9159 | momordin-Ic | Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo. |
| S5742 | Deferoxamine mesylate (Ba 33112) | Deferoxamine mesylate (Ba 33112, Desferrioxamine B, DFOM, NSC 644468)是Deferoxamine的甲磺酸盐，它可形成铁络合物并用作螯合剂。Deferoxamine 是一种铁死亡的抑制剂，可在体外低氧和高血糖状态下稳定 HIF-1α 的表达并改善HIF-1α的活性。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉积并诱导自噬。 |
| S9160 | Ziyu-glycoside I | Ziyuglycoside I is one of the major active ingredients in Sanguisorba officinalis and could be used as an active ingredient for cosmetics. |
| S9161 | Ziyuglycoside II | Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties. |
| S9162 | Rubimaillin | Rubimaillin (Mollugin), found in the Chinese medical plant Rubia cordifola, is a dual inhibitor of acetyl-CoA cholesterol acyltransferase 1 (ACAT1) and acetyl-CoA cholesterol acyltransferase 2 (ACAT2), but is more selective for the ACAT2 isozyme. |
| S9163 | Rhapontigenin | Rhapontigenin (Protigenin), produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation, is a selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM). |
| S9164 | Curdione | Curdione, one of the major components of Curcuma zedoaria, shows an excellent antithrombotic activity in vivo. |
| S9165 | Poncirin | Poncirin (Isosakuranetin-7-neohesperidoside), extracted from trifoliate orange, has anti-bacterial and anti-inflammatory activities. |
| S9167 | Columbin | Columbin, a diterpenoid furanolactone, is a potential anti-inflammatory drug. |
| S9168 | Periplogenin | Periplogenin (Desoxostrophanthidin, 5-beta-Hydroxydigitoxigenin), isolated from Lagenaria siceraria, has potent anti-psoriatic effects in vitro and in vivo. |
| S9171 | Harpagoside | Harpagoside, a natural product found in the plant Harpagophytum procumbens, has potent anti-rheumatic, anti-inflammatory and analgesic effects. |
| S9172 | Phellodendrine | Phellodendrine, a quaternary ammonium alkaloid extracted from the dried bark of Phellodendrom chinensis Schneid and Phellodendrom amurense Rupr, has the effect of suppressing cellular immune response, reducing blood pressure and antinephritis. |
| S9173 | Sec-O-Glucosylhamaudol | Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) is one of the major bioactive compounds of the Saposhnikoviae Radix. |
| S9174 | Xanthotoxol | Xanthotoxol (8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen), a biologically active linear furocoumarin found in a large number of plants, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects. |
| S9175 | Macranthoidin A | Macranthoidin A, found in the herbs of Lonicera japonica Thunb., has anti-inflammation activity. |
| S9176 | Pimpinellin | Pimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity. |
| S9177 | Gypenoside XLIX | Gypenoside XLIX, a naturally occurring gynosaponin, is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator. |
| S9178 | Sinapine thiocyanate | Sinapine thiocyanate is the thiocyanate salt form of Sinapine, which shows favorable biological activities such as antioxidant and radio-protective activities. |
| S9179 | Catharanthine hemitartrate | Catharanthine hemitartrate is the starting material for the synthesis of the antitumor drugs vinblastine and vincristine. |
| S9180 | Tussilagone | Tussilagone, isolated from the flower of buds of Tussilago farfara (Compositae), is a sesquiterpenoid that is used as a traditional oriental medicine for asthma and bronchitis. It shows anti-inflammatory activity in in vitro studies. |
| S9181 | Periplocin | Periplocin (Periplocoside)是从传统草药皮质骨膜中提取的，具有心脏和抗癌活性。Periplocin 可以显著地促进成纤维细胞L929细胞的增殖、迁移和刺激胶原蛋白的产生，这取决于 Na/K-ATPase 介导的Src/ERK和PI3K/Akt信号通路的激活，从而促进伤口愈合 。 |
| S9182 | Crebanine | Crebanine, an aporphine alkaloid isolated from the crude hexane extract of the dried tuber of Stephania venosa, exhibits anti-cancer effects. |
| S9183 | Ruscogenin | Ruscogenin, a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been reported to exert significant anti-inflammatory and anti-thrombotic activities. |
| S9184 | Forsythoside B | Forsythoside B 是从中药民间植物轮枝（Lamiophlomis rotata Kudo）的叶子中分离出来的一种苯乙胺类苷。Forsythoside B 具有有效的神经保护作用，并具有抗发炎、抗氧化和防腐特性。Forsythoside B 可以抑制 TNF-alpha、IL-6、IκB 并调节 NF-κB。 |
| S9185 | Nitidine Chloride | Nitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity. |
| S9455 | Isorhamnetin 3-O-neohesperoside | Isorhamnetin 3-O-neohesperoside is the major active substance of Puhuang, a traditional herb medicine widely used in clinical practice to tackle many chronic diseases. It has significant biological and pharmacological activities, including antioxidant, antiatherogenic and antimicrobial effects. |
| S9511 | Crocin I | Crocin is a carotenoid pigment of saffron that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer. |
| S9515 | Polyphyllin VII | Polyphyllin VII (Y-0166), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocellular carcinoma and osteosarcoma. |
| S5129 | D-Aspartic acid | D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA). |
| S9055 | Salvianolic acid A | Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck. |
| S9052 | Auraptene | Auraptene (7-geranyloxycoumarin)是源自柑橘类植物的天然香豆素，具有重要的药理特性，包括抗癌，抗炎，抗幽门螺杆菌，抗原毒性和神经保护作用。Auraptene 可抑制 matrix metalloproteinase 2 (MMP-2) 以及关键的炎症介质，包括 IL-6、IL-8 和 chemokine (C-C motif) ligand-5(CCL5)。 |
| S9045 | Triptophenolide | Triptophenolide (Hypolide), derived from Tripterygium wilfordii, is a pan-antagonist for wild-type and mutant androgen receptors with the IC50 values of 260 nM for AR-WT, 480 nM for AR-F876L, 388 nM for AR-T877A, and 437 nM for W741C+T877A. |
| S9061 | Hydroxy safflor yellow A | Hydroxy safflor yellow A, a monomer extracted from Carthamus tinctorius L., possesses various kinds of bio-activities, including anti-oxidation, anti-inflammatory actions, anti-platelet aggregation, anti-tumor and anti-myocardial injury effects. |
| S9062 | 4-Hydroxyisoleucine | 4-Hydroxyisoleucine, an atypical branched-chain amino acid derived from fenugreek, has effects on the glucose and lipid metabolism, stimulates glucose-dependent insulin secretion and reduces insulin resistance in muscle and/or liver. |
| S9063 | Harringtonine | Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities. |
| S9064 | Trilobatin | Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect. |
| S9065 | Songorine | Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties. |
| S9066 | Specnuezhenide | Specnuezhenide (Nuezhenide), one of the main ingredients of Chinese medicine, has anti-angiogenic and vision improvement effects. |
| S9067 | Pseudoprotodioscin | Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. |
| S9068 | Trillin | Trillin (Disogluside, Diosgenin glucoside) is an active ingredient isolated from Trillium tschonoshii Maxim and acts as a potential anti-inflammatory drug for chronic hepatic inflammation. |
| S9069 | Jatrorrhizine chloride | Jatrorrhizine chloride (Neprotine, Yatrorhizine) is the hydrochloride salt form of jatrorrhizine, which is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE. |
| S9070 | Isoxanthohumol | Isoxanthohumol is one of the most important prenylflavonoids found in hops. It exhibits an antiproliferative activity against human breast cancer cell lines, ovarian cancer, prostate cancer, and colon cancer cells. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). |
| S9072 | Sweroside | Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects. |
| S9073 | Lithospermoside | Lithospermoside (Griffonin), extracted from the roots of Lithospermum purpurocaeruleum and L.officinale (Borginaceae), and Thalictrum rugosum and T. dasycarpum (Ranunculaceae), has anti-oxidant, anti-tumor promoting activities. |
| S9074 | Buddlejasaponin IVb | Buddlejasaponin IVb (Saikosaponin 1b), a major component of Pleurospermum kamtschaticum, exerts anti-inflammatory and cytotoxic effects against cancer cells. |
| S9075 | Mulberroside A | Mulberroside A 是从 Morus alba 根的乙醇提取物中分离出的，具有抗酪氨酸酶和抗氧化活性，并被广泛用作化妆品中的活性成分。Mulberroside A 降低 TNF-α、IL-1β 和 IL-6 的表达并抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化。 |
| S9076 | Typhaneoside | Typhaneoside is a flavonoid glycoside plant extract that has an inhibitory effect on the proliferation of human umbilical arterial smooth muscle cell(HUASMC). |
| S9077 | Plantamajoside | Plantamajoside (Y0160, C10485), a hydroxycinnamic acid, is used as a biomarker in chemotaxonomical studies, and is a compound with numerous biological applications and considerable pharmacological potential. |
| S9078 | Epigoitrin | Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities. |
| S9079 | Ginsenoside Rb2 | Ginsenoside Rb2 (Ginsenoside C) is a ginsenoside found in Panax ginseng that has a role as a plant metabolite, an antiviral agent and a hypoglycemic agent. |
| S9080 | Anhydroicaritin | Anhydroicaritin (Cycloicaritin), a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs. |
| S9081 | Anemoside B4 | Anemoside B4 (Pulchinenoside B4, Chinensioside A, Pulchinenoside C, Pulsatilla saponin B4), extracted from the herb of Pulsatilla chinensis (Bge.) Regel, is a potential antiviral constituent and inhibits the secretion of IL-10. |
| S9082 | Manninotriose | Manninotriose, found in many foods, is a novel and important player in the RFO metabolism of red dead deadnettle. |
| S9083 | Rhapontin | Rhapontin (Ponticin, Rhaponticin, Rhapontigenin glucoside), a stibene-type glycoside distributed widely in medicinal plants of Rheum genus (Polygonaceae), has anti-inflammatory effect and anti-proliferative activity. |
| S9084 | Rhoifolin | Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects. |
| S9085 | Corynoline | Corynoline is one of the major active components of many ethnopharmacological plants and exhibits anti-tumor, anti-inflammatory and hepatoprotective activities, etc. |
| S9111 | Isorhamnetin | Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity. |
| S9112 | Kaempferitrin | Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities. |
| S9113 | Ononin | Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects. |
| S9101 | Ingenol | Ingenol, a plant-derived diterpenoid, is a weak PKC activator and possesses important anticancer activity. |
| S9019 | Quillaic acid | Quillaic acid is the major aglycone of the widely studied saponins of the Chilean indigenous tree Quillaja saponaria Mol and shows strong anti-inflammatory activity. |
| S9020 | Dihydrotanshinone I | Dihydrotanshinone I (15,16-dihydrotanshinone I) is a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, also known as Chinese sage, red sage root, and the Chinese herbal Dan Shen. It is a potent inhibitor of the HuR:RNA interaction, active in the low nanomolar range, mainly by limiting the association rate of HuR with RNA. |
| S9021 | (20R)Ginsenoside Rg3 | (20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite. |
| S9022 | 20S-Ginsenoside Rg3 | 20S-Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It exihits neuromodulatory, cognition enhancing, anti-inflammatory, antioxidative, anti-angiogenic, and anticancer activities. |
| S9023 | 20S-Ginsenoside Rh2 | 20S-Ginsenoside Rh2 is a ginsenoside found in Panax species and inhibits cancer development, progression, and metastasis. |
| S9026 | Hastatoside | Cimifugin is a bioactive component of Saposhnikovia divaricata, a Chinese herb for treating allergy. |
| S9029 | Prim-o-glucosylcimifugin | Prim-O-glucosylcimifugin (Cimifugin beta-D-glucopyranoside, Cimifugin 7-glucoside) 是防风(Radix Saposhnikovia)中的主要成分，长期以来一直应用于传统中医药中治疗发热、风湿和癌症，它表现出潜在的抗癌活性。在LPS激活的 RAW 264.7 巨噬细胞，Prim-O-glucosylcimifugin 可以浓度依赖性的方式下调 NO synthase (iNOS) 和 cyclooxygenase 2 (COX-2) 的mRNA和蛋白质表达。 |
| S9031 | Gambogenic acid | Gambogenic Acid, identified from Gamboge, is an inhibitor of the FGFR signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects. Gambogenic acid acts is also an effective inhibitor of EZH2 that specifically and covalently binds to Cys668 within the EZH2-SET domain, and triggers EZH2 ubiquitination. |
| S9034 | Isochlorogenic acid C | Isochlorogenic acid C (3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid), which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71. |
| S9039 | Albiflorin | Albiflorin, a natural product isolated from Paeoniae Radix, is a novel 5-HT and NE reuptake inhibitor with high selectivity. |
| S9040 | Maslinic acid | Maslinic Acid (Crategolic Acid, 2α-Hydroxyoleanoic Acid), a Natural Triterpene, exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. MA significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells. |
| S9054 | Pectolinarin | Pectolinarin 是Cirsium setidens的一种主要化合物，具有抗炎活性。Pectolinarin 可抑制 IL-6 和 IL-8 的分泌以及 PGE2 和 NO 的产生。Pectolinarin 通过 PI3K/Akt 信号通路的失活来诱导凋亡。 |
| S9050 | Boldine | Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects. |
| S9049 | Parishin A | Parishin A, isolated from the rhizomes of Gastrodia elata, has good neuroprotective effects against brain disorders. |
| S9060 | Nystose | Nystose (1,1-Kestotetraose, Fungitetraose), a constituent of seeds of onions and roots of Asparagus, is a low-calorie sweetening agent for food and chewing gum. |
| S9092 | Norisoboldine | Norisoboldine (Laurelliptine), a natural aryl hydrocarbon receptor (AhR) agonist, attenuates ulcerative colitis (UC) and induces the generation of Treg cells. |
| S9093 | Nardosinone | Nardosinone, isolated from Nardostachys root, an important Chinese herbal medicine, is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities. |
| S9097 | Alisol B Acetate | Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways. |
| S9098 | Dehydrodiisoeugenol | Dehydrodiisoeugenol, a naturally occurring lignan from Aristolochia taliscana (Aristolochiaceae), acts as a potent anti-inflammatory agent and shows various pharmacological activities, including anti-lipid peroxidation, anti-bacteial function, and hepatic drug metabolism enzyme inhibition. |
| S9099 | Orientin | Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects. |
| S9100 | Fraxinellone | Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities. |
| S9102 | Magnolin | Magnolin is a natural compound abundantly found in Magnolia flos targeting ERK1 (IC50=87 nM) and ERK2 (IC50=16.5 nM) and inhibits cell transformation induced by tumor promoters such as epidermal growth factor (EGF). |
| S9103 | Ginsenoside Ro | Ginsenoside Ro (Chikusetsusaponin V), one of the high-abundance saponins in ginseng, is widely used as a dietary supplement and has many health-promoting effects. |
| S9104 | Maltopentaose | Maltopentaose is a substrate for energy metabolism and carbon for E. coli. |
| S9105 | Ginsenoside CK | Ginsenoside CK is a ginsenoside found in Panax species and has a role as a plant metabolite, an antineoplastic agent, a hepatoprotective agent, an anti-allergic agent and an anti-inflammatory agent. |
| S9108 | Timosaponin A3 | Timosaponin A3 (Filiferin B, AneMarsaponin A3), one of the major steroidal saponin components isolated from Anemarrhena asphodeloides, displays promising pharmacological activity in improving learning, memory, and antineoplastic activity. |
| S9056 | Tuberostemonine | Tuberostemonine, a natural product found in Stemona phyllantha and Stemona tuberosa, is an alkaloid and a metabolite. |
| S9053 | Irisflorentin | Irisflorentin derived from the roots of Belamcanda chinensis (L.) DC. is an herb which has been used for the treatment of inflammatory disorders in traditional Chinese medicine. |
| S9051 | Asperulosid | Asperuloside, an iridoid glycoside found in Herba Paederiae, is a component from traditional Chinese herbal medicine and exerts anti-inflammatory effect. |
| S9048 | (+)-Gallocatechin | (+)-Gallocatechin, found notably in green tea, has moderate affinity to the human cannabinoid receptor and acts as an antioxidant. |
| S9057 | Sinigrin | Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects. |
| S9058 | Gallocatechin gallate | Gallocatechin galleate (GCG) is a polyphenol originally derived from a variety of sources, including green tea, coffee, safflower, and almonds. |
| S9086 | Dihydrocapsaicin | Dihydrocapsaicin (6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589), found in pepper (C. annuum), is a potential nutriceutical. |
| S9088 | Calycosin-7-O-beta-D-glucoside | Calycosin-7-O-beta-D-glucoside, an isoflavone glycoside isolated from A. mongholicus and A. membranaceus, has antioxidant, anti-inflammatory, and neuroprotective biological activities. |
| S9089 | Magnoflorine | Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase. |
| S9090 | Corilagin | Corilagin, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. It is an inhibitor of TNF-α. |
| S9091 | 10-Gingerol | 10-Gingerol is a bioactive compound found in ginger with anti-inflammatory and antioxidant activity. |
| S9095 | Senegenin | Senegenin (Tenuigenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory activity. |
| S9096 | ligustroflavone | Ligustroflavone (Nuezhenoside), isolated from the leaves of Turpinia montana, shows high antioxidant capacity and is reported to be an AMPK activator. |
| S9106 | Eleutheroside E | Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction. |
| S9107 | Glycitein | Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities. |
| S9109 | 1-Kestose | 1-Kestose (1F-beta-D-Fructosylsucrose), a fructooligosaccharide, could efficiently stimulates Faecalibacterium prausnitzii as well as Bifidobacteria in humans. |
| S9110 | Morin | Morin (Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum), a constituent of various woods, has a role as an antioxidant, a metabolite, an antihypertensive agent, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an antineoplastic agent, an antibacterial agent, a DNA topoisomerase inhibitor and an angiogenesis modulating agent. |
| S4700 | 4-Aminobutyric acid (GABA) | 4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid)是一种天然存在的神经递质，具有抑制中枢神经系统的活性。 |
| S5580 | Arabic gum | Arabic gum, derived from exudates of Acacia senegal or Acacia seyal trees, is a complex polysaccharide indigestible to both humans and animals and considered as a safe dietary fiber. |
| S3774 | Dehydroandrographolide Succinate Potasium Salt | Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect. |
| S9008 | 20-Deoxyingenol | 20-Deoxyingenol is a natural compound isolated from the seeds of Euphorbia lathyris L. |
| S5145 | Protoporphyrin IX | Protoporphyrin IX (PPIX) is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway. |
| S5288 | Estropipate | Estropipate (Piperazine estrone sulfate, Estrone sulfate piperazine salt, Pipestrone) is a natural estrogenic substance composed of estrone sulfate and piperazine and is used mainly in menopausal hormone therapy in the treatment of menopausal symptoms. |
| S3917 | Tetrahydrocurcumin | Tetrahydrocurcumin (Tetrahydrodiferuloylmethane, Tetrahydro Curcumin), a major metabolite of curcumin, possesses strong antioxidant and cardioprotective properties. |
| S5675 | Yamogenin | Yamogenin, a sapogenin found in fenugreek, inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes. |
| S5373 | Pseudolaric Acid B | Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties. |
| S5676 | Zearalenone | Zearalenone (F2 toxin, RAL) is a non-steroidal estrogenic mycotoxin that acts by binding the estrogen receptor (ER). |
| S5678 | trans-Zeatin-riboside | Zeatin Riboside is the most active and ubiquitous form of the naturally occurring cytokinins that promote cell division, stimulate shoot proliferation, inhibit root formation, slow the aging process, and activate gene expression and metabolic activity. |
| S5705 | Raceanisodamine | Raceanisodamine (7β-Hydroxyhyoscyamine) is the active ingredient of Chinese herbal extracts that has vasoactive activity used to treat acute disseminated intravascular coagulation in patients in bacteremic shock. |
| S3843 | Madecassoside | Madecassoside (Asiaticoside A)是积雪草草药的主要活性三萜烯成分，积雪草是一种传统中药，用于治疗创伤修复和疤痕管理。 |
| S5560 | Midecamycin | Midecamycin (Espinomycin A, Medecamycin A1, Platenomycin B1, Rubimycin, Turimycin P3) is a naturally occuring macrolide antibiotic that acts by inhibiting bacterial protein synthesis. |
| S5559 | Tetrahydropalmatine | Tetrahydropalmatine (Rotundine), a plant alkaloid used as an ingredient in dietary supplement products, is a potent and selective D1 receptor antagonist. |
| S5466 | Saikosaponin A | Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inflammatory, immunomodulatory, and anti-bacterial activities. |
| S5622 | Prohydrojasmon | Prohydrojasmon is a newly launched plant growth regulator, which has jasmonic acid activity. |
| S5493 | Atropine sulfate | Atropine Sulfate (Sulfatropinol, Atropette, Tropintran) is the sulfate salt of atropine, which is a natural alkaloid anticholinergic agent and has potent antimuscarinic effects. |
| S5102 | Stachyose | Stachyose is a natural sugar found in many foods like beans and vegetables. |
| S4545 | Warfarin | Warfarin (Athrombine K, Coumadin, Coumafene, WARF 42, Zoocoumarin) 是一种广泛使用的抗凝剂，用来抗血栓形成和血栓栓塞、阻止血管中血凝块的形成和迁移。 |
| S3991 | Ketoisophorone | Ketoisophorone (4-Oxoisophorone), also known as 4-Oxoisophorone, is the major component of saffron spice. |
| S3992 | D-(+)-Trehalose dihydrate | Trehalose是一种非还原糖，提高植物和动物对脱水的抵抗力。 |
| S3993 | Ethyl Vanillate | Ethyl vanillin (Bourbonal, Ethylprotal) 是一种香草醛类似物，可用作调味剂和杀真菌剂，具有很强的抗氧化活性。Ethyl Vanillate 抑制 17β-HSD2 的IC50值为1.3 µM。 |
| S3994 | Methyl Cholate | Methyl Cholate (Cholic acid methyl ester) is methyl ester form of Cholic acid that is a primary bile acid mainly produced by the liver. |
| S3995 | Guaiazulene | Guaiazulene (Azulon, Vetivazulen) 是一种双环倍半萜烯，是一些精油的组成成分。 |
| S3996 | Thioctic acid | Thioctic acid (DL-α-Lipoic acid)是环状二硫抗氧化剂，可与其还原性二硫酚形式相互转换。 |
| S3998 | (+)-α-Lipoic acid | (+)-α-Lipoic acid ((R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid)是thioctic acid的生理形式之一，是一种强效的抗氧化剂，可减轻糖尿病神经性症状。它比其外消旋体具有更优越的抗氧化性。R(+)-α-lipoic acid 是线粒体酶复合物的必要辅助因子。R(+)-α-lipoic acid 抑制 NF-κB 依赖性HIV-1 LTR 活化。 |
| S5157 | Thymol | Thymol (2-isopropyl-5-methylphenol, IPMP), a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro. |
| S5161 | 1-Octacosanol | 1-Octacosanol (n-Octacosanol, Octacosyl alcohol, Octanosol, Montanyl alcohol, Cluytyl alcohol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is used as a nutritional supplement. It is reported to possess cholesterol-lowering effects, antiaggregatory properties, cytoprotective use, and ergogenic properties. |
| S5172 | 1-Triacontanol | 1-Triacontanol (n-Triacontanol, Melissyl alcohol, Myricyl alcohol) is a fatty alcohol found in plant cuticle waxes and in beeswax. It is a growth stimulant for many plants, most notably roses. |
| S5143 | Citropten | Citropten (5,7-Dimethoxycoumarin, Citroptene, Limettin, Limetin) is a natural organic compound which belongs to coumarins and derivatives class. |
| S5142 | D-(+)-Melezitose | Melezitose (D-Melezitose, (+)-Melezitose, D-melicitose, (+)-melicitose, melicitose) is a nonreducing trisaccharide sugar that is produced by many plant sap eating insects. |
| S5141 | Pyrithioxin | Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity. |
| S5132 | Casanthranol | Casanthranol is a purified mixture of te antranol glycosides derived from Cascara sagrada. |
| S5128 | Orsellinic acid ethyl ester | Orsellinic acid (Ethyl Orsellinate), a phenolic acid, is of importance in the biochemistry of lichens, from which it can be extracted. |
| S4954 | Djenkolic Acid | Djenkolic Acid (Jengkolic acid, Djenkolate, S,S'-Methylenebiscysteine) is a naturally occurring sulfur-containing amino acid extracted from djenkol beans. It is toxic to humans, often causing kidney failure. |
| S4827 | Manganese chloride | Manganese chloride在自然界中以矿物质形式存在。它常被用作其他锰化合物的合成前体。 |
| S4969 | Tropine | Tropine (Pseudotropine, 3alpha-Tropanol) 是一种天然存在的莨菪烷生物碱，是多种具有生物活性的生物碱合成的中间体，这些生物碱大多具有有效的神经学作用。 |
| S4940 | Maltol | Maltol (Larixinic acid, Palatone, Veltol)是一种天然有机化合物，可作为香味增强剂和调味剂。 |
| S4859 | TriacetonaMine | TriacetonaMine (Tempidon, Tmpone, Odoratine, Vincubine)，作为一种哌啶酮（Piperidinone），是一种具有极弱酸性的化合物，存在于绿色植物和茶中。 |
| S4863 | 4-Hydroxyphenylacetic acid | 4-Hydroxyphenylacetic acid (p-Hydroxyphenylacetic acid, parahydroxy phenylacetate) 是一种存在于橄榄油和啤酒中的化合物，作为一种化学中间体用于合成阿替洛尔（atenolol）和3,4-dihydroxyphenylacetic acid。 |
| S4864 | 2-Furoic acid | 2-Furoic acid (2-Furancarboxylic acid, Pyromucic acid, 2-Carboxyfuran, α-furancarboxylic acid, α-furoic acid)是一种广泛用于食品生产的有机化合物，作为防腐剂和增味剂。 |
| S4949 | Nonanoic acid | Nonanoic acid (Pelargonic acid, Nonoic acid) 是一种天然存在于蔬菜和动物脂肪中的脂肪酸。 |
| S4862 | Squalene | Squalene (Spinacene, Supraene, trans-Squalene)，自然存在于植物、动物和人体中，是一种添加在疫苗中佐剂，用于增强免疫反应。 |
| S4943 | Isovanillin | Isovanillin (5-Formylguaiacol, 3-Hydroxy-p-anisaldehyde, 3-Hydroxy-4-methoxybenzaldehyde)是醛脱氢酶（aldehyde oxidase）的可逆性抑制剂。它被广泛用作药物中间体，应用于食物和饮料行业、化学合成香料和化学分析领域。 |
| S4951 | L-Threonine | L-Threonine是一种必需氨基酸，处于活化形式。它对于胶原蛋白、弹性蛋白和牙釉质的形成十分重要，连同天冬氨酸、甲硫氨酸一起发挥滋养肝脏、抗脂肪肝的作用。 |
| S4952 | Fumaric acid | Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) 是三羧酸循环中的中间产物。细胞利用三羧酸循环从食物中产生能量（ATP形式）。Fumaric acid还是尿素循环的产物。 |
| S4953 | Usnic acid | Usnic acid (Usniacin)是存在于lichen（地衣）中的一种呋喃二酮，广泛应用于化妆品、除臭剂、牙膏和药用霜、中草药成品中。它具有抗病毒、抗原生动物、抗增殖和抗炎、止痛活性。Usnic acid 可通过抑制VEGFR2介导的 AKT 和 ERK1/2 信号通路来抑制乳腺肿瘤血管生成和生长。 |
| S4960 | Jasmone | Jasmone是一种天然有机化合物，分离自茉莉花油的挥发成分。 |
| S4957 | Linalool | Linalool (Phantol)是一些芳香剂中的香精油的主要成分。它是NMDA receptors的竞争性拮抗剂。 |
| S4941 | Farnesol | Farnesol是一种天然的倍半萜烯醇，有效地治疗抗代谢障碍、具有抗炎、抗氧化、抗肿瘤和抗菌活性。 |
| S5122 | Abietic Acid | Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM. |
| S5126 | Aleuritic Acid | Aleuritic Acid (Aleuritolic acid, 9,10,16-trihydroxy-palmitic acid), a major constituent acid of lac resin (shellac), is isolated from the resin and mainly used in the perfumery industry as a starting material for the preparation of "musk" aroma compounds as well as medicinal and bioactive compounds. |
| S5134 | D(-)-Arabinose | D-Arabinose is a reducing sugar useful as a substrate in analysis of arabinose isomerases and synthesis of D-erythroascorbic acid in yeast. |
| S5135 | Hydroferulic acid | Hydroferulic acid (Dihydroferulic acid, Dihydroconiferylic acid) is classified as a member of the phenylpropanoic acids. It is slightly soluble in water and acidic. |
| S4828 | Sodium carbonate | Sodium Carbonate (Disodium carbonate, Soda Ash, Carbonic acid disodium salt) 是碳酸的二钠盐形式，具有碱化特性。 |
| S4939 | cis-Aconitic acid | Cis-Aconitic acid (cis-aconitate, Achilleic acid, Citridinic acid, Equisetic acid, Pyrocitric acid)是三羧酸循环中的中间产物，由柠檬酸脱水形成。 |
| S4946 | 2,3-Dihydroxybenzoic acid | 2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) 是一种天然酚类，存在于西印度醋栗和水生蕨类Salvinia molesta，也是人体中阿司匹林的代谢产物。它是一种潜在的铁螯合药物，具有抗菌特性。 |
| S4962 | Agmatine sulfate | Agmatine sulfate是精氨酸的活性代谢产物，能够提高一氧化氮水平、减少血糖水平并提高生长激素水平。 |
| S4893 | Cytosine | Cytosine (4-Amino-2-hydroxypyrimidine, Cytosinimine)是存在于DNA和RNA中的四种主要碱基中的一种，被细胞用于储存和传输遗传信息。 |
| S4958 | Glycocholic acid | Glycocholic acid (Cholylglycine, Glycocholate) 是一种天然的次级胆汁酸，参与脂肪的乳化。 |
| S4820 | Diastase | Diastase是天然存在的、可催化淀粉分解为麦芽糖的酶。 |
| S4959 | Skatole | Skatole (3-methylindole, Scatole)是一种具有轻度毒性的白色结晶有机化合物，天然存在于排泄物中，具有相当广泛的抑菌作用。 |
| S4963 | Purpurin | Purpurin (1,2,4-Trihydroxyanthraquinone, Hydroxylizaric acid, Verantin)是从茜草根和其他茜草科植物家族中分离出的天然色素。它具有抗血管生成、抗菌、抗氧化活性。Purpurin 可有效地抑制CYP1A1、CYP1A2 和 CYP1B1。 |
| S4966 | 4-Methylesculetin | 4-methylesculetin是香豆素衍生物，具有强大的抗氧化和抗炎活性。4-Methylesculetin 可抑制 myeloperoxidase (MPO) 活性并降低 IL-6 水平。 |
| S4968 | Cholesteryl Acetate | Cholesteryl Acetate (Acebrochol, Cholesterol, Cholesterin)，天然存在于不同液体、器官和食物中，是一种正常的人类胆甾醇酯。 |
| S4830 | Maltose | Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose)，一种能够提供能量的非必需营养物，是糖原和淀粉的肠道消化过程中的中间产物，存在于发芽的谷物或其他植物、蔬菜中。 |
| S5160 | 4-Methoxysalicylic acid | 4-Methoxysalicylic acid (2-Hydroxy-p-anisic Acid), an arabinose derivative, is used in the synthesis of 1,3,4-oxadiazole derivatives. |
| S5162 | Isovanillic acid | Isovanillic acid (Acide isovanillique, 3-Hydroxyanisic acid, 3-Hydroxy-p-anisic acid), a metabolite of isovanillin, is a selective inhibitor of aldehyde oxidase. |
| S5163 | 7-Methoxycoumarin | 7-Methoxycoumarin (Herniarine), also known as Herniarin, is a methoxy derivative of coumarin and substrate for dealkylase. It has been used in the synthesis of anti-first-pass effect compounds and detergents. |
| S3950 | Maltitol | Maltitol (Maltisorb, 4-O-α-glucopyranosyl-D-sorbitol) is a sugar alcohol (polyol) used as a sugar substitute. It is especially useful in the production of sweets, including sugarless hard candies, chewing gum, chocolates. |
| S3951 | Tannic acid | Tannic acid (Gallotannic acid) 是一种多酚化合物，是一种具有抗血管生成，抗炎和抗肿瘤活性的 CXCL12/CXCR4 的抑制剂。 |
| S5113 | Propyl gallate | Propyl gallate (Gallic acid propyl esterZ, n-Propyl gallate) is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products. |
| S4799 | Indole-3-acetic acid | Indole-3-acetic acid (indolylacetic acid, 1H-Indole-3-acetic acid, indoleacetic acid, heteroauxin, IAA) is the most common plant hormone of the auxin class and it regulates various aspects of plant growth and development. |
| S5167 | Benzyl cinnamate | Benzyl cinnamate (Cinnamein, Benzylcinnamoate, Benzyl 3-phenylpropenoate, Cinnamic acid benzyl ester), a flavouring agent isolated from various plant species, is used in heavy oriental perfumes and as a fixative. |
| S5168 | Anthraquinone | Anthraquinones (Anthradione, anthracenedione, dioxoanthracene) are the main active constituents in herbs often used to relieve constipation. |
| S5174 | Kojic acid | Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives. |
| S5175 | (-)-Ambroxide | Ambroxide, a naturally occurring terpenoid, is one of the key constituents responsible for the odor of ambergris and an autoxidation product of ambrein. |
| S4762 | 2,4-Dihydroxyacetophenone | 2,4-Dihydroxyacetophenone (Resacetophenone, 4-Acetylresorcinol) is a plant metabolite that can act as a qualitative reagent for ferric iron. |
| S4765 | Syringaldehyde | Syringaldehyde (Syringic aldehyde) is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications. |
| S4768 | Melibiose | Melibiose (Galalpha1-6Glcbeta) is a nondigestible disaccharide that consists of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage. |
| S5110 | Safflower Yellow | Safflower Yellow (Safflor Yellow, SY), the main active constituent of the traditional Chinese medicine Safflower, is known as a neuroprotective agent that indirectly attenuates neuroinflammation. |
| S5116 | Bilibubin | Bilirubin is a tetrapyrrole and a breakdown product of heme catabolism that acts as a physiological, chain-breaking antioxidant. |
| S4769 | L-5-Hydroxytryptophan | 5-Hydroxytryptophan (5-HTP, L-oxitriptan), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin. |
| S4770 | Creatine phosphate disodium salt | Phosphocreatine, also known as creatine phosphate (CP) or PCr (Pcr), is a phosphorylated creatine molecule that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle and the brain to recycle adenosine triphosphate, the energy currency of the cell. |
| S4771 | β-thujaplicin | β-Thujaplicin (β-TH, Hinokitiol, 4-Isopropyltropolone) is a toxic tropolone derivative present in the heartwood of western red cedar (Thuja plicata) and is used as a preservative and antimicrobial additive in a number of commercial goods. Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities. |
| S4772 | alpha-Asarone | Alpha (α)-asarone (trans-Asarone) is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects. |
| S4773 | Adrenosterone | Adrenosterone (Reichstein's substance G, 11-ketoandrostenedione, 11-oxoandrostenedione) is endogenous steroid hormone that has been promoted as a dietary supplement capable of reducing body fat and increasing muscle mass. |
| S4774 | Xanthurenic Acid | Xanthurenic acid (xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3). |
| S4776 | Harmaline | Harmaline, a natural occurrence β-carboline alkaloid, is a central nervous system stimulant and an acetylcholinesterase (AChR) inhibitor; also inhibits histamine N-methyltransferase. |
| S4777 | Plumbagin | Plumbagin (Plumbagine, Plumbaein, Plumbagone), a quinoid constituent isolated from the root of the medicinal plant Plumbago zeylanica L, exerts anticancer and antiproliferative activities in animal models and in cell culture. |
| S3896 | (1R,2R)-trans-N-Boc-1,2-cyclohexanediamine | (1R,2R)-trans-N-Boc-1,2-cyclohexanediamine is an intermediate in organic synthesis. |
| S3897 | (-)-Arctigenin | (-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer. |
| S4781 | Xanthoxyline | Xanthoxylin (Brevifolin), isolated from Zanthoxylum piperitum (Japanese pepper tree) and Sapium sebiferum (Chinese tallowtree), is a cytotoxic and fungicidal compound with the characteristics of a typical phytoalexin. |
| S3899 | Hederagenin | Hederagenin (Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E) is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo. Hederagenin inhibits LPS-stimulated expression of iNOS, COX-2, and NF-κB. |
| S3900 | Betulonic acid | Betulonic acid (Liquidambaric acid), derived from betulinol, a pentacyclic styrene, has shown a highly specific anti-prostate cancer activity in in vitro cell cultures. |
| S4783 | Benzyl isothiocyanate | Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities. |
| S3902 | Ursonic acid | Ursonic acid (Prunol, Malol, beta-Ursolic acid, NSC4060, CCRIS 7123, TOS-BB-0966), present in many plants, is a pentacyclic triterpenoid that can be used as a cosmetics additive and serve as a starting material for synthesis of more potent bioactive derivatives, such as experimental antitumor agents. |
| S4784 | Phloracetophenone | Phloracetophenone, or 2,4,6-trihydroxyacetophenone (THA), the aglycone component of phloracetophenone glucoside, is a naturally occurring compound obtained from the rhizome of Curcuma comosa (Family Zingiberaceae). |
| S3903 | Lycorine | Lycorine (Galanthidine, Amarylline, Narcissine, Licorine, Belamarine) is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis. |
| S3904 | Isoimperatorin | Isoimperatorin, a natural furanocoumarin that can be isolated from a variety of plant parts, has analgesic, antimicrobial, vascular relaxing and anticancer activities. |
| S3905 | Iso-Steviol | Isosteviol (ISV) is mainly obtained by acid hydrolysis of stevioside, the sweet food additive extracted from the plant Stevia Rebaudiana Bertoni (Bertoni). It possesses various biological activities including anti-hyperglycemic, anti-hypertensive, anti-tumor, anti-inflammatory, and antioxidant effects. |
| S4788 | L-α-Phosphatidylcholine | L-α-phosphatidylcholine, a surfactant and a constituent of the liposomal carrier system, has shown hepatoprotection in the various hepatotoxicity model. |
| S4791 | S-allyl-L-cysteine | S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. |
| S4793 | Cedryl acetate | Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity. |
| S4809 | 3-Indolepropionic acid | 3-Indolepropionic acid (IPA, indole-3-propionic acid), a gut microbial metabolite, is a potent neuroprotective antioxidant and plant auxin. |
| S5124 | DL-Citrulline | L-Citrulline (Citrulline, Cit) is a naturally occurring nonessential amino acid which is the key intermediate in the urea cycle. |
| S5136 | Calcium folinate | Calcium folinate (Leucovorin calcium, Folinic acid calcium salt, Wellcovorin) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives. |
| S3980 | Pyridoxine | Pyridoxine (Pyridoxol, Vitamin B6, Gravidox), also known as vitamin B6, is a form of vitamin B6 found commonly in food and used as dietary supplement. It is a cofactor for both glutamic acid decarboxylase and GABA transaminase. |
| S3967 | Flavone | Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc. |
| S3975 | Protocatechuic acid | Protocatechuic acid (PCA, 3,4-Dihydroxybenzoic acid, Protocatechuate), a dihydroxybenzoic acid, is a type of widely distributed naturally occurring phenolic acid. |
| S3976 | Acetylvanillin | Acetylvanillin (Acetovanillin, Vanillin acetate, 4-Acetoxy-3-methoxybenzaldehyde, 4-Formyl-2-methoxyphenyl acetate) is found in pulses and is a flavouring material. |
| S3977 | (-)-Borneol | (-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odor. |
| S4821 | Glycine | Glycine (2-Aminoacetic acid, Aminoacetic acid, Glycocoll) is a non-essential, non-polar, non-optical, glucogenic amino acid that is primarily found in gelatin and silk fibroin. It is involved in the body's production of DNA, phospholipids and collagen, and in release of energy. |
| S4826 | Aluminium hydroxide | Aluminium hydroxide (Aluminic), found in nature as the mineral gibbsite, is amphoteric (i.e., it has both basic and acidic properties). It is used to treat symptoms of increased stomach acid, such as heartburn, upset stomach, sour stomach, or acid indigestion; also reduce phosphate levels in people with certain kidney conditions. |
| S3986 | L-Arabinose | L-Arabinose (L-Ara) 是一种植物糖，不存在于动物中。它是细胞壁的成分之一，可能用于天然药物的合成。 |
| S3987 | L-Tryptophan | L-tryprophan是必需氨基酸，是一种天然的情绪调节剂，为婴幼儿正常生长、成人氮平衡所必需。 |
| S3989 | L-Hisidine | L-Hisidine (Glyoxaline-5-alanine) 是一种α-氨基酸，是人类生长和组织修复所必需，被用于蛋白质的生物合成。 |
| S3990 | Trans-Anethole | Trans-anethole (4-Propenylanisole)是苯丙烯衍生物，存在于多种香精油、包括茴香油中。它具有神经调节、抗焦虑、抗氧化、抗真菌、抗炎症和免疫调节活性。 |
| S4972 | Choline Glycerophosphate | Choline Glycerophosphate (Glycerophosphorylcholine) 是胆碱衍生物，是胞浆中两种主要的胆碱储存形式之一。 |
| S4981 | Cyclogalegenol | Cyclogalegenol (Astramembrangenin, Cyclosieversigenin) 是astragaloside A的糖苷配基衍生物，存在于多种紫云英属物种中，可能可激活端粒酶。 |
| S4982 | 2,2':5',2''-Terthiophene | 2,2':5',2''-Terthiophene是来源于金盏花的天然产物，具有受紫外线增强的抗菌活性。 |
| S4983 | Sorbic acid | Sorbic acid (2,4-Hexadienoic acid) is a naturally occurring compound that originated from the unripe berries of the Rowan Tree. It inhibits various bacteria, including sporeformers, at various stages of their life cycle (germination, outgrowth and cell division). |
| S2323 | Methyl-Hesperidin | Methyl-Hesperidin 是一种在柑橘类水果中广泛存在的黄酮苷（黄酮）（C28H34O15），其苷元形式被称为橙皮素。 |
| S5090 | 4-Isopropylbenzyl Alcohol | 4-Isopropylbenzyl Alcohol (Cumic alcohol, Cuminyl alcohol, Cuminic alcohol)，分离自赤桉，是一种具有杀虫作用的化合物。 |
| S5091 | Geranyl acetate | Geranyl acetate (Geraniol acetate, Geranyl ethanoate) 是一种天然有机化合物，主要用作面霜和肥皂的香料或是调味成分。 |
| S5089 | 4-Isopropylbenzaldehyde | 4-Isopropylbenzaldehyde (Cuminaldehyde, Cuminic aldehyde, Cuminal)，一种天然有机化合物，是一种药物中间体，具有宜人的香味，有助于香精油中的香气。 |
| S5086 | p-Anisaldehyde | p-Anisaldehyde (4-Methoxybenzaldehyde, Anisaldehyde, Anisic aldehyde, P-Methoxybenzaldehyde, 4-Anisaldehyde)，茴芹种子提取物，具有抗真菌活性，对很多酵母和实验室培养基、果泥和果汁中的霉菌菌株具有活性。 |
| S5220 | D-Pantethine | Pantethine (Bis-pantethine, Pantetina, Pantomin, Pantosin)是一种天然产物，在体内由泛酸（维生素B5）通过半胱胺的加入合成，被用作一种食品添加剂，降低血胆固醇和三酸甘油脂。 |
| S3982 | Batyl alcohol | Batyl alcohol (Batilol, Stearyl monoglyceride, 1-O-Octadecylglycerol, Batilolum), isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent. |
| S5156 | 4-Methoxysalicylaldehyde | 4-Methoxysalicylaldehyde (2-Hydroxy-4-methoxybenzaldehyde), a naturally occurring product, has a range of industrial applications in the preparation of organic compounds, drugs and therapeutic agents. |
| S5154 | Tetrahydropiperine | Tetrahydropiperine (Cosmoperine), derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects. |
| S5155 | Raffinose | Raffinose (Melitose, Melitriose) is a complex carbohydrate, a trisaccharide composed of galactose, fructose, and glucose. It can be broken apart into galactose and sucrose via the enzyme alpha-galactosidase. |
| S5226 | L-carnosine | L-carnosine (Karnozin) is an antioxidant naturally found in skeletal muscle, brain tissue, and the heart that protects cells against oxidative stress. |
| S3970 | Vindoline | Vindoline is a chemical precursor to vinblastine and exhibits antimitotic activity by inhibiting microtubule assembly. |
| S5570 | Arachidic acid | Arachidic acid (eicosanoic acid, Icosanoic Acid) is a natural saturated fatty acid used for the production of detergents, photographic materials and lubricants. |
| S3971 | Fusidine | Fusidine (Fusidic Acid), isolated from Fusidium coccineum, is a steroidal antibiotic that inhibits protein synthesis. |
| S3972 | Lobeline hydrochloride | Lobeline hydrochloride is an alkaloid that acts on nicotinic cholinergic receptors but is less potent than nicotine. It is also a VMAT2 ligand and an antagonist of μ-opioid receptors. |
| S5562 | 2-Hydroxybenzyl alcohol | 2-Hydroxybenzyl alcohol (Salicyl alcohol, Salicain, Diathesin, Saligenin, Saligenol, o-Methylolphenol, α,2-Toluenediol), which can be found in a number of food items such as red huckleberry, rye, jerusalem artichoke, and ceylon cinnamon, is precursor of salicylic acid and is formed from salicin by enzymatic hydrolysis by Salicyl-alcohol beta-D-glucosyltransferase or by acid hydrolysis. |
| S5335 | Corey Lactone Diol | Corey Lactone Diol is a pharmaceutical intermediate. |
| S5336 | Hecogenin | Hecogenin (Hocogenin), a steroid saponin isolated from Agave sisalana, is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM. |
| S5338 | L(-)-Sorbose | L(-)-Sorbose (L(-)-Sorbopyranose) is a ketose sugar that is commonly used in the commercial synthesis of ascorbic acid. |
| S5343 | Vanillic acid | Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a flavoring agent which is also an intermediate in the production of vanillin from ferulic acid. Vanillic acid inhibits NF-κB activation. Anti-inflammatory, antibacterial, and chemopreventive effects. |
| S5337 | Rauwolscine hydrochloride | Rauwolscine hydrochloride (Isoyohimbine, α-Yohimbine, corynanthidine) is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM. |
| S5342 | Dihydrojasmone | Dihydrojasmone, belonging to the family of ketones, is an aroma compound for perfumery uses. |
| S5339 | 4-Allylanisole | 4-Allylanisole (Estragole, p-Allylanisole, Methyl chavicol) is a natural organic compound that is a component of various trees and plants. It is used in the preparation of fragrances. |
| S3785 | Notoginsenoside R1 | Notoginsenoside R1 (Sanchinoside R1) is the main ingredient with cardiovascular activity in Panax notoginseng. It inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways. |
| S5345 | Nerolidol | Nerolidol (Peruviol) is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties. |
| S5347 | 2-Phenylethylamine | 2-Phenylethylamine (β-Phenylethylamine, benzeneethanamine, β-aminoethylbenzene) is a natural monoamine alkaloid that functions as a monoaminergic neuromodulator or a neurotransmitter in the human central nervous system. |
| S5348 | Pherocon (4-(4-Acetoxyphenyl)-2-butanone) | Pherocon (4-(4-Acetoxyphenyl)-2-butanone, 4-(p-Acetoxyphenyl)-2-butanone, 4--(3-Oxobutyl)phenyl acetate) is a standard melon fly attractant for detection programs. |
| S5440 | Berberine Sulfate | Berberine sulfate (Umbellatine), an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa. |
| S3772 | 5-Hydroxymethylfurfural | 5-Hydroxymethylfurfural (5-HMF) is an important bio-sourced intermediate, formed from carbohydrates such as glucose or fructose and used for production of fuels and chemical intermediates. |
| S3792 | Guggulsterone E&Z | Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity. |
| S5407 | Squalane | Squalane (Perhydrosqualene, Dodecahydrosqualene) is a naturally occuring lipid in both plants and animals. It is usually used as an emollient and moisturizer in cosmetics manufacturing. |
| S3805 | Stevioside | Stevioside is a natural sweetener extracted from leaves of Stevia rebaudiana (Bertoni) Bertoni. |
| S5583 | Cinnamyl acetate | Cinnamyl acetate (3-Phenylallyl acetate) is a naturally occuring compound used as a flavouring agent. |
| S5584 | Citronellol | Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells. |
| S5419 | 1,4-Cineole | 1,4-Cineole (Isocineole) is a flavor constituent of Citrus aurantifolia and Piper cubeba. |
| S3894 | Cycloastragenol | Cycloastragenol (CAG, TA-65, Cyclogalegigenin, Astramembrangenin) is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells. |
| S5380 | 7-Hydroxyflavone | 7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2. It also has excellent antioxidant properties and great potential to be applied as medicines. |
| S3895 | Sophoridine | Sophoridine (5-Epidihydrosophocarpine, Dihydro-5-episophocarpine), a natural product obtained from medicinal plants, has a variety of pharmacological effects, including anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems. |
| S5381 | Behenic Acid | Behenic Acid (docosanoic acid) is a long-chain saturated fatty acid that exists naturally as a triglyceride in canola. It act as a lubricant that helps restore the skin's natural oils and improve overall levels of hydration. |
| S3849 | D-Galactose | D-Galactose (D-Galactopyranose, D-(+)-Galactose) is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging. |
| S3850 | Glucosamine sulfate | Glucosamine sulfate (D-Glucosaminesulfate, D-Glucosamine sulphate) is a dietary supplement commonly used in the treatment of osteoarthritis. It is a type of glycosaminoglycan, which is a naturally occurring major component of joint cartilage and joint fluid. |
| S3851 | Camphor | Camphor (2-Bornanone, Bornan-2-one, 2-Camphanone, Formosa) is a bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora and used topically as a skin antipruritic and as an anti-infective agent. |
| S3852 | L-Theanine | L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis and is known to promote relaxation without sedation. |
| S3854 | Tetrahydropalmatine hydrochloride | Tetrahydropalmatine (THP, Gindarine, 1-Tetrahydropalmitine) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. It is a potent muscle relaxant. |
| S3855 | Ethyl ferulate | Ethyl ferulate (Ferulic acid ethyl ester) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferative activities. |
| S3856 | Allantoin | Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria. |
| S3857 | 4-Hydroxybenzyl alcohol | 4-hydroxybenzyl alcohol (P-Methylolphenol, 4-Methylolphenol), an important phenolic constituent of Gastrodia elata Blume (GEB), has been shown to have many beneficial effects in different animal models of neurological disorders, such as, headaches, convulsive behavior, dizziness, and vertigo. |
| S3858 | Lawsone | Lawsone (Hennotannic acid, 2-hydroxy-1,4-naphthoquinone) is a red-orange dye present in the leaves of the henna plant (Lawsonia inermis) as well as in the flower of water hyacinth (Eichhornia crassipes). |
| S3859 | Vanillyl Alcohol | Vanillyl alcohol (4-Hydroxy-3-methoxybenzyl alcohol, Vanillin alcohol, Vanillic alcohol, 3-Methoxy-4-hydroxybenzyl alcohol), derived from vanillin, is used to flavor food. |
| S5618 | Hippuric acid | Hippuric Acid (2-Benzamidoacetic acid, Benzoylglycine) is an acyl glycine produced by the conjugation of benzoic acid and glycine, found as a normal component in urine as a metabolite of aromatic compounds from food. |
| S3862 | Gallic acid trimethyl ether | Gallic acid trimethyl ether (Eudesmic acid, Tri-O-methylgallic acid, Benzoic acid, 3,4,5-Trimethoxybenzoic acid) is an O-methylated trihydroxybenzoic acid that is found in olive. |
| S3864 | Dulcitol | Dulcitol (Galactitol, D-Galactitol, Dulcose) is a naturally occurring product of plants obtained following reduction of galactose. |
| S3865 | Taurochenodeoxycholic acid | Taurochenodeoxycholic acid (Taurochenodeoxycholic acid (Taurochenodeoxycholate, TCDCA, Chenodeoxycholyltaurine)), a bile acid formed in the liver of most species, is used as a cholagogue and choleretic. |
| S3866 | Galanthamine | Galantamine (Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine) is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disease and other central nervous system disorders. |
| S3868 | Harmine | Harmine (Telepathine) is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but not the variant MAO-B. |
| S3870 | D-Pinitol | D-pinitol (Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol) is a naturally occurring compound derived from soy and has significant pharmacological activitites such as inhibition of the T-helpercell-1 response, antiviral, larvicidal, antiinflammatory, antihyperlipidemic, cardioprotective, inhibition of ovalbumin-induced airway inflammation and antioxidant. |
| S3872 | Guaiacol | Guaiacol (O-methoxyphenol, 2-hydroxyanisole, O-methylcatechol) is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. It is a precursor to various flavorants, such as eugenoland vanillin. Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity. |
| S5461 | Cimicifugoside | Cimicifugoside is a triterpenoid originating from the rhizomes of Cimicifuga simplex, and acts to inhibit the subcellular transport of nucleosides. |
| S5454 | Saikosaponin D | Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is a type of Saponin derivative, which is a component extracted from Bupleurum falactum. Saikosaponin D has anti-cancer activities. |
| S3981 | Sinapinic Acid | Sinapinic acid (Sinapic acid) 是一种天然的小羟基肉桂酸，属于苯基丙烷类，通常在MALDI质谱中用作基质。Sinapinic acid (Sinapic acid) 作为 HDAC 的抑制剂，IC50为2.27 mM，并且还抑制 ACE-1 活性。 |
| S3983 | Caryophyllene oxide | Caryophyllene oxide是存在于多种植物精油中的氧化萜类化合物，在食物、药物和化妆品中被用作防腐剂，具有消炎、抗癌和增强皮肤渗透活性。 |
| S3984 | Nordihydroguaiaretic acid (NDGA) | Nordihydroguaiaretic acid (NDGA)是一种天然存在的酚类防老剂。它是公认的脂肪氧合酶 lipoxygenase抑制剂，具有抗氧化、清除自由基的活性。Nordihydroguaiaretic acid (NDGA) 是一种具有细胞毒性的 insulin-like growth factor-I receptor (IGF-1R)/HER2 的抑制剂，可诱导细胞凋亡。Nordihydroguaiaretic acid (NDGA) 可抑制 p300 并激活自噬。Nordihydroguaiaretic acid (NDGA) 可保护细胞免于铁死亡。 |
| S5105 | Proanthocyanidins | Proanthocyanidins (PAs), also known as condensed tannins, are a class of polyphenols found in a variety of plants. They are very powerful antioxidants that remove harmful free oxygen radicals from cells. |
| S5148 | 2-Methylenebutyrolactone | 2-Methylenebutyrolactone (Tulipalin A, MBL, α-methylene-γ-butyrolactone)，也被称作α-methylene-γ-butyrolactone (MBL) 或Tulipalin A，是一种倍半萜内酯，被认为是最常见乙烯基单体甲基丙烯酸甲酯（MMA）的环状类似物。 |
| S5119 | Olivetol | Olivetol (5-Pentylresorcinol, 5-n-Amylresorcinol) is a naturally occurring organic compound being a precursor in various syntheses of tetrahydrocannabinol. It acts as a competitive inhibitor of the cannabinoid receptors CB1 and CB2. |
| S5150 | Phytosterols | Phytosterols，也被称作植物甾醇或醇酯，存在于植物中，结构类似于人体中胆固醇。 |
| S5151 | Gypenoside | Gypenoside (GP)是绞股蓝中的主要有效成分，具有消炎和抗氧化活性。 |
| S3956 | Tetramethylpyrazine | Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities. |
| S3957 | Gamma-Oryzanol | Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass. |
| S3959 | (+)-Borneol | (+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine. |
| S3962 | Dihydroactinidiolide | Dihydroactinidiolide is known to be a bioactive molecule in animals. It is a component of pheromones in insects, such as red fire ants and in mammals such as the Cat and the Red Fox. |
| S3963 | DL-Glutamine | DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. |
| S3968 | Histamine | Histamine, an organic nitrogenous compound, is involved in local immune responses regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is a potent H1 and H2 receptor agonist. |
| S5120 | Elemicin | Elemicin (3,4,5-trimethoxyallylbenzene) is a constituent of the oleoresin and the essential oil of Canarium luzonicum. |
| S5121 | Phytol | Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα. |
| S5139 | Methyl Dihydrojasmonate | Methyl dihydrojasmonate (Hedione, Kharismal) is a flavouring ingredien with the smell vaguely similar to jasmin. |
| S5138 | Citral | |
| S4754 | Betulin | Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. |
| S3955 | Uric Acid | Uric Acid (2,6,8-Trioxypurine, 2,6,8-Trihydroxypurine, 2,6,8-Trioxopurine), a normal component of urine, is a product of the metabolic breakdown of purine nucleotides. |
| S4766 | Gibberellic acid | Gibberellic acid (Gibberellin, Gibberellin A3, GA3, GA), a plant hormone stimulating plant growth and development, is a tetracyclic di-terpenoid compound. |
| S3948 | Spermine | Spermine (4,9-Diaza-1,12-dodecanediamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. |
| S2283 | Cinchonine(LA40221) | Cinchonine (LA40221)是一种生物碱，是cinchonidine的立体异构体和假对映异构体。. |
| S3654 | Tauroursodeoxycholic Acid (TUDCA) | Tauroursodeoxycholic acid (TUDCA)是乌索脱氧胆酸的牛磺酸共轭产物，在多种神经退行性疾病，如阿尔茨海默病、帕金森疾病和亨廷顿疾病中，可作为线粒体稳定剂和抗凋亡试剂。 |
| S3752 | isoleucine | Isoleucine (Ile) is a non-polar, uncharged (at physiological pH), aliphatic amino acid that is used in the biosynthesis of proteins. |
| S3753 | L-Leucine | Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. |
| S3653 | Spermidine trihydrochloride | Spermidine (4-Azaoctamethylenediamine) 是一种从腐胺和dcSAM中，通过亚精胺合成酶合成的天然聚胺。它是新型的自噬诱导剂，负向调控N-methyl-d-aspartate (NMDA)。 |
| S3754 | 4-Hydroxybenzoic acid | 4-Hydroxybenzoic acid (p-hydroxybenzoic acid, PHBA, para-Hydroxybenzoic acid, 4-hydroxybenzoate), also known as p-hydroxybenzoic acid (PHBA), is a phenolic derivative of benzoic acid and widely used in organic synthesis. It is the most widely distributed aromatic organic acid in the vegetable kingdom. |
| S3893 | Bornyl acetate | Bornyl acetate (Isobornyl, Bornyl acetic ether, 2-Camphanol), the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic. |
| S3758 | Sinomenine hydrochloride | Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent. |
| S3755 | Betaine | Betaine (trimethylglycine, glycine betaine, lycine, oxyneurine), a methyl derivative of glycine first isolated from sugar beets, has been shown to have potential benefits for fighting heart disease, improving body composition, and helping promote muscle gain and fat loss because of its abilities to promote protein synthesis in the body. |
| S3757 | 2'-Deoxyinosine | 2’-Deoxyinosine (Guanine deoxyriboside, Deoxyinosine) is the nucleoside form of hypoxanthine. It is a product of DNA damage that is formed from 2’-deoxyadenosine by adenosine deaminase or reactive nitrogen species. 2’-deoxyinosine enhances apoptosis induced by 5-fluorouracil in HT-29 and SW620 cancer cells. |
| S3770 | Sodium Aescinate | Sodium Aescinate (SA, Escin Sodium Salt) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic. Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway. |
| S3681 | Vitamin E Acetate | Vitamin E Acetate (Tocopherol) is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant. |
| S3853 | Perillyl alcohol | Perillyl alcohol (Perilla alcohol, Isocarveol) is a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants. |
| S3871 | Muscone | Muscone (3-Methylcyclopentadecanone, Methylexaltone)是一种增香成分，一种有机化合物，是麝香气味的主要来源，也是一种有效的消炎剂。Muscone 可显著地下调LPDM诱导的炎症细胞因子水平，并抑制BMDM中 NF-κB 和 NLRP3 炎性小体的活化。Muscone 还可以显著地降低炎性细胞因子inflammatory cytokines (IL-1β, TNF-α, IL-6) 的水平。 |
| S3762 | Methylnonylketone | Methylnonylketone (2-Undecanone, IBI-246), also known as 2-Undecanone and IBI-246, is a natural non-toxic insect repellant compound. |
| S3789 | Tiglic acid | Tiglic acid (Cevadic acid, Sabadillic acid, Tiglinic acid) is a monocarboxylic unsaturated organic acid found in croton oil and in several other natural products. It is used in making perfumes and flavoring agents. |
| S3791 | Succinic acid | Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism. |
| S3793 | Phytic acid | Phytic acid (Inositol polyphosphate, Inositol hexakisphosphate) is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. It can act as a cofactor in DNA repair by nonhomologous end-joining. |
| S3794 | Palmitic acid | Palmitic acid (Hexadecanoic acid, Cetylic acid) is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity. |
| S3795 | Phloretic acid | Phloretic acid (Desaminotyrosine, Hydro-p-coumaric acid, Phloretate, 3-(4-Hydroxyphenyl)propanoic acid) is a naturally occurring phenolic compound which can be produced by the hydrogenation of p-coumaric acid or synthesized from phloretin, a by-product of apple tree leaves. |
| S3796 | Rebaudioside A | Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste. |
| S3797 | Helicide | Helicide (4-formylphenyl-O-β-d-allopyranoside), a main active constituent from seeds of the Chinese herb Helicia nilagirica, has been reported to exert a sedative, analgesic and hypnotic effect, and is used clinically to treat neurasthenic syndrome, vascular headaches and trigeminal neuralgia. |
| S3799 | Gentisic acid | Gentisic acid (2,5-dihydroxybenzoic acid, 5-Hydroxysalicylic acid, Hydroquinonecarboxylic acid, DHB), an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties. |
| S3717 | Testosterone Enanthate | Testosterone Enanthate (Testosterone heptanoate, NSC-17591)是一种雄激素和合成代谢类固醇，用于治疗雄性素补疗。 |
| S3802 | Trigonelline Hydrochloride | Trigonelline (Nicotinic acid N-methylbetaine, Coffearine, Gynesine), a major alkaloid component of fenugreek, has hypoglycemic, hypolipidemic, neuroprotective, antimigraine, sedative, memory-improving, antibacterial, antiviral, and anti-tumor activities, and also has been shown to reduce diabetic auditory neuropathy and platelet aggregation. |
| S3803 | Angelic acid | Angelic acid ((Z)-2-Methylbut-2-enoic acid) is a monocarboxylic unsaturated organic acid that is mostly found in the plants of the family Apiaceae. |
| S3812 | Monocrotaline | Monocrotaline (MCT, Crotaline) is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) that causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension, and cor pulmonale. |
| S3886 | Quinic acid | Quinic acid (Chinic acid, Kinic acid) is a crystalline acid obtained from cinchona bark, coffee beans, and other plant products and made synthetically by hydrolysis of chlorogenic acid. |
| S3887 | α-L-Rhamnose monohydrate | α-L-Rhamnose monohydrate (6-deoxy-L-mannose monohydrate, α-L-Rhamnopyranose monohydrate) is used as a starting material for the production of furanones. It is an important material involved in the reaction of flavors developed during the preparation of various foods like bread, grilled meats, etc. |
| S3742 | Cholic acid | Cholic acid是一种天然胆汁酸，在水中不可溶，用来治疗具有合成胆汁酸遗传缺陷的患者。 |
| S3679 | Flavanone | Flavanones (2,3-Dihydroflavone, 4-Flavanone, 2-Phenyl-4-chromanone, 2-Phenylchroman-4-one)具有较强的抗氧化和清除自由基活性，可能可减少某些慢性疾病的风险、阻滞一些心血管疾病以及某些癌症。Flavanones还具有抗病毒、抗菌、消炎活性，对毛细管脆性有一定改善效果、抑制人血小板凝聚、抗溃疡、降低过敏反应。 |
| S4808 | L-Cystine | L-Cystine is the oxidized dimer form of the amino acid L-cysteine which is a non-essential amino acid of the human body. It is required for wound healing and formation of epithelial tissue. |
| S4811 | VitaMin U | Vitamin U (Methylmethioninesulfonium Chloride, Cabagin-U, Smethylmethionine) is a vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract. |
| S5107 | Riboflavin phosphate sodium | Riboflavin phosphate sodium (Flavin mononucleotide, riboflavin-5'-phosphate, FMN, Vitamin B2 Phosphate Sodium Salt) is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as prosthetic group of various oxidoreductases including NADH dehydrogenase as well as cofactor in biological blue-light photo receptors. |
| S5108 | Tylosin | Tylosin (Fradizine, Tylocine, Tylosine, Tylosin A) is a macrolide-class broad spectrum antibiotic that's used in veterinary medicine to treat felines, canines and livestock. |
| S3626 | Sesamol | Sesamol (1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol)是一种天然有机化合物，是油中主要的抗氧化成分，具有化学防癌、抗诱变剂和抗毒肝素活性。它能诱导癌细胞和心血管细胞凋亡。 |
| S3625 | Tyramine | Tyramine (4-hydroxyphenethylamine, para-tyramine, mydrial, uteramin) 是一种来源于氨基酸酪氨酸的天然微量胺，是一种儿茶酚胺释放试剂。 |
| S3624 | Quinolinic acid | Quinolinic Acid (pyridine-2,3-dicarboxylic acid, QUIN)是犬尿氨酸途径中的具有神经活性的代谢物，是N-methyl-D-aspartate (NMDA)受体的激动剂。 |
| S3629 | Syringic acid | Syringic acid (NSC 2129, SYRA) 是一种有效的抗氧化中草药，是一种新兴的营养食品。它具有潜在的抗血管生成、抗糖基化、抗高血糖、神经保护和增强记忆的活性。 |
| S3630 | Methyl Vanillate | Methyl Vanillate是枳椇子成分之一，在体外能激活Wnt/β-catenin信号通路并诱导成骨分化。 |
| S5362 | Citicoline | Citicoline (CDP-choline, cytidine 5'-diphosphocholine) is a naturally occurring compound that acts as nutrient with a broad spectrum of benefits for conditions associated with symptoms of neurological dysfunction. As an endogenous compound, it is also an essential intermediate in the synthesis of cell membrane phospholipids and its formation is the rate-limiting step in phosphatidylcholine synthesis. |
| S5368 | Lactitol | Lactitol is a versatile, reduced calorie sweetener derived from natural milk sugar, used in a wide variety of sweetening applications. |
| S4955 | Acetosyringone | Acetosyringone (Acetosyringenin) is a phenolic natural product with analgesic, antipyretic and anti-inflammatory actions. |
| S5571 | L-Asparagine | L-Asparagine (2-Aminosuccinamic acid, alpha-aminosuccinamic acid) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. |
| S5594 | α-Terpineol | α-Terpineol, a natural monoterpene, is the major component of essential oils of several species of aromatic plants such as Origanium vulgare L. and Ocimum canum Sims which are widely used for medicinal purposes. It is widely used in the manufacturing of cosmetics, soaps, perfumes, antiseptic agents and is considered one of the most frequently used fragrance compounds. |
| S5576 | Benzyl acetate | Benzyl acetate (Acetic acid benzyl ester, Benzyl ethanoate, Phenylmethyl), usually found in alcoholic beverages, is a flavouring agent. |
| S5585 | Citronellal | Citronellal (Rhodinal, 2,3-Dihydrocitral), a monoterpenoid found in oil of citronella, lemon, and lemon grass, has insect repellent properties and is used in perfumes. |
| S5598 | p-Cymene | p-Cymene (4-Isopropyltoluene, 4-Methylcumene, Paracymene) is a naturally occurring aromatic organic compound produced by high purity separate technique which is applied in distilling of gum turpentine oil. |
| S3675 | Umbelliferone | Umbelliferone (7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone) is a 7-hydroxycoumarin that is a pharmacologically active agent. It is a fluorescing compound used as a sunscreen agent and shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals with anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities. |
| S3677 | Cinnamic acid | Cinnamic acid (Benzenepropenoic acid, Isocinnamic acid, trans-Cinnamic acid, Phenylacrylic acid), a naturally occurring aromatic fatty acid of low toxicity, induces cytostasis and a reversal of malignant properties of human tumor cells in vitro. |
| S3661 | 2-Methoxy-1,4-naphthoquinone | 2-Methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera, specifically suppressed the expression of PKC βI, δ, and ζ in a concentration-dependent manner in Raji cells. |
| S3652 | 3-Nitropropionic acid | 3-Nitropropionic acid (β-Nitropropionic Acid, 3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain. |
| S5513 | Calcium D-saccharate tetrahydrate | Calcium D-saccharate tetrahydrate (Calcium Saccharate, D-Saccharic acid calcium salt, D-Glucaric acid calcium salt) is the calcium salt form of glucaric acid, a natural substance found in many fruits and vegetables, with potential anti-cancer property. |
| S5518 | D-Glucose 6-phosphate disodium salt | D-Glucose 6-phosphate disodium salt is the disodium salt form of D-Glucose 6-phosphate, a common form of glucose within the cell, participating in two major metabolic pathways: glycolysis and the pentose phosphate pathway. It can be coverted to glycogen or starch for storage. |
| S2416 | Chondroitin sulfate | Chondroitin sulfate是一种硫酸化糖胺多糖（GAG），组成交替糖分包括乙酰半乳糖胺和葡萄糖醛酸。 |
| S5327 | Meisoindigo | Meisoindigo (N-Methylisoindigotin, Methylisoindigotin, Dian III), a derivative of Indigo naturalis, is an active compound of a Chinese anti-leukemia medicine that has been effectively used in the treatment of chronic myelogenous leukemia (CML). |
| S5599 | Sodium cholate | Sodium cholate (NaCh) is the sodium salt of the naturally occurring cholic acid, a bile salt produced by the liver, with strong solubilization capacity of water-insoluble substances. |
| S5575 | 2-Benzoxazolinone | 2-Benzoxazolinone (BOA, 2-Hydroxybenzoxazole), a well-known allelochemical with strong phytotoxicity, is a potential herbicidal candidate and probably functions via interfering with auxins or disrupting membrane integrity. |
| S5579 | Chelidonic acid | Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) 是在几种植物中发现的次级代谢产物，对实验动物的过敏性疾病具有治疗潜力。Chelidonic acid 通过阻断HMC-1细胞中的 NF-κB 和 caspase-1 来抑制 IL-6 的产生。Chelidonic acid 也是 glutamate decarboxylase 的抑制剂，其Ki值为1.2 μM。 |
| S5588 | Creatine | Creatine (Methylguanidoacetic acid) 是一种天然存在于脊椎动物中的含氮有机酸。Creatine 可以通过抑制 IFN-γ receptors 与 JAK2 的相互作用来抑制 JAK-STAT1 信号传递，以ATP非依赖性的方式促进三磷酸腺苷（ATP）的循环，从而抑制下游促炎基因表达。 |
| S5614 | (+)-Longifolene | (+)-Longifolene is a naturally occurring, oily liquid hydrocarbon found primarily in the high-boiling fraction of certain pine resins. |
| S3619 | Citicoline sodium | Citicoline (CDP-choline) 是细胞膜主要的磷脂--卵磷脂合成的必要中间产物。它能够提高血浆促肾上腺皮质激素水平以及强化血清促甲状腺素水平。 |
| S5595 | 3-Carene | 3-Carene (Carene, Delta-3-Carene)是在从松树中提取的精油中的双环单萜。 3-Carene对 COX-2 过表达和LPS诱导的Raw264.7巨噬细胞迁移具有强大的药理作用。3-Carene被证明可显着刺激 alkaline phosphatase 的活性和表达 ，是成骨细胞分化的早期标志。 |
| S5376 | Decyl aldehyde | Decyl aldehyde (Decanal, Capraldehyde, Decanaldehyde) is a naturally occuring organic compound that is used in fragrances and flavoring. |
| S5551 | 6-Paradol | 6-Paradol is a minor constituent of ginger, mainly formed from 6-gingerol via 6-shogaol, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activities. |
| S5379 | Fenchyl Alcohol | Fenchyl Alcohol is used as a flavoring agent to provide a pine, herbal, lemon, or floral taste to food and drink. |
| S5530 | Geraniol | Geraniol is a terpene alcohol occurring in the essential oils of several aromatic plants used in the flavour and fragrance industries. It also exhibits insecticidal and repellent properties and used as a natural pest control agent exhibiting low toxicity. |
| S5237 | Dihydroartemisinic acid | Dihydroartemisinic acid is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal herb that is widely used to treat Malaria. |
| S5516 | Ellagic Acid hydrate | Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties. |
| S3612 | Rosmarinic acid | Rosmarinic acid (RA, Rosemary acid) 是一种天然的羟化化合物。它具有阻止补体结合、抑制脂肪氧合酶和环氧煤活性的功能，通过抑制NF-κB激活信号中IKK-β的活性、抑制CCL11和CCR3的表达。 |
| S3609 | Berbamine dihydrochloride | Berbamine (BA, BBM) dihydrochloride 是一种从中草药黄芦木中分离而来的双苄基异喹啉类天然产物。它是bcr/abl的新型抑制剂，具有有效的抗白血病活性，是NF-κB的抑制剂。Berbamine (BA, BBM) dihydrochloride 通过靶向 Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) 抑制癌细胞的生长，并诱导人骨髓瘤细胞凋亡。 |
| S5459 | Aucubin | Aucubin (Rhinanthin), an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages. |
| S5471 | Monotropein | Monotropein, an iridoids glycoside isolated from the roots of Morinda officinalis How, has been demonstrated to exhibit anti-inflammatory activity. |
| S5452 | Sanguinarine chloride | Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. |
| S5458 | Verbascoside | Verbascoside (Acteoside, Kusaginin), a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant. |
| S5467 | Asarinin | Asarinin (Sesamin, Fagarol, Pseudocubebin, Episesamin, Eleutheroside B4), isolated as a racemate from the shrub Zanthoxylum alatum, is usually used as a dietary fat-reduction supplement. |
| S5455 | Akebia saponin D | Akebia saponin D (Asperosaponin VI), the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures. |
| S5553 | Kasugamycin hydrochloride | Kasugamycin is an aminoglycosidic antibiotic isolated from Streptomyces kasugaensis, showing broad-spectrum anti-fungal activity against yeast and various fungus species. |
| S5529 | Galangin | Galangin (3,5,7-trihydroxyflavone; Norizalpinin), a naturally occuring flavonoid found in herbs, is a well-known antioxidant and also an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor. |
| S5453 | Hyperoside | Hyperoside (Hyperin, Quercetin 3-galactoside), a naturally occuring flavonoid compound, exerts multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.Hyperoside can inhibit activation of the NF-κB signaling pathway. |
| S5460 | Vitexin-2-O-rhaMnoside | Vitexin-2-O-rhamnoside (2''-O-Rhamnosylvitexin, Apigenin-8-C-glucoside) is one of the main components of flavonoid of the leaves of Crataegus pinnatifida Bge. var major N. E. Br. It has many biological and pharmacological activities, such as antioxidation and treating heart disease. |
| S5468 | Kaempferol-3-O-glucorhamnoside | Kaempferol 3-neohesperidoside (Kaempferol 3-neohesperidoside), isolated from the herbs of Delphinium grandiflorum L., has insulin-like properties in terms of glucose lowering. |
| S5465 | Morroniside | Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. |
| S5463 | Curcurbitacin IIA | Curcurbitacin IIA (Cucurbitacin Iia, CuIIa, Hemslecin A, Dihydrocucurbitacin Q1) is the major active component of the Helmseya amabilis root and is known to have antiviral and anti-inflammatory effects. |
| S5469 | Bavachin | Bavachin (Corylifolin) is a phytoestrogen purified from natural herbal plants such as Psoralea corylifolia. It acts as a weak phytoestrogen by binding and activating the ER. |
| S5462 | 5-O-Methylvisammioside | 5-O-Methylvisammioside is a naturally occuring product isolated from Saposhnikovia Divaricata and has analgesic, antipyretic, anti-inflammatory and anti-platelet aggregation effects. |
| S5451 | Ferulic acid methyl ester | Ferulic acid methyl ester (Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate) is a lipophilic derivative of ferulic acid, which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer. |
| S5456 | Isobavachalcone | Isobavachalcone (Corylifolinin), a naturally occurring chalcone compound derived from the seeds of Psoralea corylifolia L., has long been used in traditional Chinese medicine as anthelmintic, antibacterial, aphrodisiac, astringent and antiplatelet agent. |
| S5512 | Juglone | Juglone (Regianin, 5-Hydroxy-1,4-naphthoquinone), a natural naphthoquinone found in the black walnut and other plants, has moderate antifungal activity and growth-stimulating effects to many types of plants. It sometimes can be used as an herbicide, as a dye for cloth and inks, and as a coloring agent for foods and cosmetics. |
| S3880 | Schisantherin A | Schisantherin A (Gomisin C, Schisanwilsonin H, Arisanschinin K)是一种五味子红素，具有止咳、镇静、消炎、抗骨质疏松、神经保护、增强认知和心脏保护活性。Schisantherin A 也可通过IκBα降解抑制p65-NF-κB向核内移位。 |
| S3882 | Brassinolide | Brassinolide是来源于Brassica napus pollen的植物类脂醇，可促进细胞延长、细胞分裂，从而调节植物生长和发育。 |
| S2376 | Ammonium Glycyrrhizinate | Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt)是来自Licorice root的一种独特产品，具有极高的甜味。Ammonium Glycyrrhizinate 是 HMGB1 的直接抑制剂，具有抗炎、抗肿瘤、抗糖尿病的作用。Ammonium Glycyrrhizinate 可抑制几种不相关的DNA和RNA病毒的生长和细胞病理。Ammonium Glycyrrhizinate 还可抑制 hepatic delta 4-5-reductase 和 11 beta-hydroxysteroid dehydrogenase。 |
| S2291 | Diosgenin | Diosgenin 是一种类固醇皂甙元，为半合成孕激素的前体，在早期与口服避孕药一起使用。 |
| S3776 | Sophoricoside | Sophoricoside (SOPH)是一种分离自槐花（豆科）的异黄酮，具有多种药理作用，如消炎、抗癌、抑制免疫力等效应。 |
| S5249 | Coptisine chloride | Coptisine (Q-100696, NSC-119754)是一种分离自黄连的吲哚联啶生物碱，具有抗糖尿病、抗菌、抗病毒、抗肝癌和抗白血病效应。Coptisine chloride 也是一种有效的非竞争性 IDO 的抑制剂，对应的IC50值和Ki值分别为6.3 μM和5.8 μM。 |
| S3879 | Kaempferide | Kaempferide (4'-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4'-methyl ether) 是一种从山柰根中提取的天然产物，具有多种生物活性，包括抗癌、抗炎、抗氧化、抗菌抗病毒等活性。 |
| S5049 | Thiocolchicoside | Thiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) 是一种天然存在的配糖体，来源于嘉兰百合的花种中，具有抗炎和止痛活性，同时具有显著的惊厥作用。它也是GABAA receptor的拮抗剂。 |
| S8279 | Shikonin (C.I. 75535) | Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844)是一种 Pyruvate kinase M2 (PKM2) 有效的、特异的抑制剂。它是紫草的主要成分，紫草是一种中草药，具有多种生物活性。在细胞荧光淬灭试验中，Shikonin也是TMEM16A氯离子通道的抑制剂。Shikonin 通过抑制 tumor necrosis factor-α (TNF-α) 发挥抗炎作用，并可通过抑制 proteasome 来阻止 nuclear factor-κB (NF-κB) 信号途径的激活。 |
| S3822 | Schisandrin A | Schisandrin A (Sch A, Deoxyschizandrin, Wuweizisu A) is an active component of Schisandrae Fructus with liver-protective, antitumor, and antioxidant activities. It is an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM. |
| S4738 | Arctiin | Arctiin (Arctigenin-4-Glucoside, NSC 315527) 是脂联素受体1的激动剂，具有抗肿瘤活性。 |
| S3807 | Dehydroandrographolide | Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity. |
| S8132 | Deguelin | Deguelin，一种从植物中分离出来的天然产物，是PI3K/Akt的抑制剂。 |
| S3824 | Quercitrin | Quercitrin (3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities. |
| S2383 | Gastrodin | Gastrodin (Gastrodine) 是一种多元酚，是4-羟基苄醇的葡糖苷。 |
| S2387 | Lappaconite HBr | Lappaconite HBr是从Aconitum sinomontanum Nakai 提取的一种生物碱，具有抗炎作用。 |
| S3910 | 4',7-Dimethoxyisoflavone | 4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro. |
| S3832 | Euphorbiasteroid | Euphorbiasteroid (Euphorbia factor L1)是Euphorbia lathyris L.的成分之一，通过激活AMPK信号通路抑制3T3-L1细胞的脂肪形成，并通过促进Bcl-2/Bax信号通路诱导HL-60细胞凋亡。 |
| S4884 | Trans-Zeatin | Trans-Zeatina ((E)-Zeatin) 是植物生长激素的成员之一，属于细胞分裂素，可调节细胞分裂、发育和营养加工。Trans-Zeatina ((E)-Zeatin) 可抑制UVB诱导的 MMP-1 表达，c-Jun 活化和 ERK，JNK 磷酸化和 p38 MAP kinases (MAPKs) 呈剂量依赖性。 |
| S2250 | (-)-Epigallocatechin Gallate | (-)-Epigallocatechin Gallate(EGCG) 是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase， 阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。 |
| S2290 | Dihydroartemisinin (DHA) | Dihydroartemisinin (DHA, Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol)是一种Artemisinin 的半合成衍生物，从传统中药Artemisia annua分离而来的。Dihydroartemisinin 可通过抑制 NF-κB 激活来诱导自噬和凋亡。 |
| S7409 | Anisomycin | Anisomycin (Flagecidin, Wuningmeisu C) 是一种从Streptomyces griseolus提取的抗菌性抗生素，抑制蛋白质合成，也是一种 JNK 激活剂。Anisomycin 可促进自噬与凋亡。 |
| S2295 | Emodin | Emodin 是Rhubarb, Buckthorn 和 Japanese Knotweed (Fallopia japonica)中的一种泻药树脂，是6-甲基-1,3,8-三羟蒽醌. |
| S2320 | Luteolin | Luteolin (Luteoline, Luteolol, Digitoflavone)是一种非选择性的PDE抑制剂，作用于PDE1-5，Ki分别为15.0 μM， 6.4 μM， 13.9 μM， 11.1 μM和9.5 μM。Phase 2. |
| S3818 | Tectoridin | Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy. |
| S2302 | Glycyrrhizin (NSC 167409) | Glycyrrhizin (NSC 167409, Glycyrrhizic Acid)是一种直接的高迁移率族蛋白1(HMGB1)的抑制剂，抑制依赖于HMGB1的炎症分子表达和氧化应激反应。调节p38和p-JNK信号通路，而不影响p-ERK信号通路。同时也能抑制11 beta-hydroxysteroid dehydrogenase。 |
| S4603 | Gallic acid | Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid)是一种在多种食物和草药中发现的有机酸，是有效的抗氧化剂。 |
| S3841 | Eleutheroside B | Eleutheroside B (syringin, Syringoside, Lilacin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties. |
| S3845 | Panaxadiol | Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential. |
| S3847 | Panaxatriol | Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities. |
| S3848 | Hydroxytyrosol Acetate | Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, exhibits antioxidant and anti-inflammatory effects. |
| S3778 | Patchouli alcohol | Patchouli alcohol (Patchoulol, Patchouli camphor), an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis. |
| S3912 | Cephalotaxine | Cephalotaxine is a naturally occurring alkaloid which is the structural motif of a number of compounds and has shown promising anti-cancer properties. |
| S3930 | Liquiritin | Liquiritin (LIQ, Liquiritoside, Liquiritigenin-4'-O-glucoside) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities. |
| S4758 | Crocin | Crocin (Alpha-Crocin, Gardenia Yellow)是藏红花中的一种水溶性类胡萝卜色素，被用于调味品和着色食品中的香料。在传统中药中，被用作止痛剂或镇定剂。 |
| S3874 | Curcumenol | Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation. |
| S3877 | Lysionotin | Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities. |
| S3809 | Imperatorin | Imperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle. |
| S3892 | Isopsoralen | Isopsoralen (Angelicin), also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses. |
| S3908 | 4'-Demethylpodophyllotoxin | 4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines. |
| S3938 | Bisdemethoxycurcumin (BDMC) | Bisdemethoxycurcumin (BDMC)是一种天然纯在的姜黄素去甲氧基衍生物，具有多种生物活性，如消炎和抗癌活性。 |
| S3890 | Leonurine | Leonurine, an active alkaloid extracted from Traditional Chinese Medicine Herba leonuri, exerts several biological effects, such as antidiabetic, cardiovascular, and bovine mastitis protection. |
| S3816 | Dehydroevodiamine | Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells. |
| S5144 | Neferine | Neferine ((R)-1,2-Dimethoxyaporphine) 是 Nelumbo nucifera 的天然成分，具有抗肿瘤功效。Neferine 可诱导肾癌细胞凋亡。Neferine 通过激活肌肉细胞中的 Akt/mTOR 通路和 Nrf2 来防止自噬。Neferine 可抑制 NF-κB 的激活。Neferine具有多种治疗作用，例如抗糖尿病，抗衰老，抗微生物，抗血栓形成，抗心律不齐，抗炎甚至抗HIV。 |
| S4761 | Thymoquinone | Thymoquinone (TQ) is the bioactive phytochemical constituent of the seeds oil of Nigella sativa with anti-inflammatory and anti-oxidant effects. |
| S3906 | Astragalus polyphenols | Astragalus is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body. It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions. |
| S3907 | Bulleyaconi cine A | Bulleyaconi cine A (Bulleyaconitine A, BLA) is an active ingredient of Aconitum bulleyanum plants and classified as an "aconitine-like" alkaloid. It is a potent use-dependent blocker for both Nav1.7 and Nav1.8 Na+ currents. |
| S3909 | Catalpol | Catalpol (Catalpinoside, Digitalis purpurea L), an iridoid glucoside contained richly in the roots of the small flowering plant species Rehmannia glutinosa Libosch, has been shown to have antioxidation, anti-inflammation, anti-apoptosis and other neuroprotective properties and plays a role in neuroprotection against hypoxic/ischemic injury, AD and PD in both in vivo and in vitro models. |
| S3922 | (-)-epigallocatechin | (-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions. |
| S3923 | Ginsenoside Rg1 | Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1)是人参的主要活性成分之一，被确定为原人参三醇型，对多种癌症具有药理作用，例如神经保护和抗肿瘤作用。Ginsenoside Rg1 可降低 cerebral Aβ 水平并减少 NF-κB 核转移。 |
| S3924 | Ginsenoside Rb1 | Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS. |
| S3925 | (-)-Epicatechin gallate | (-)-Epicatechin gallate (ECG) 是一种 cyclooxygenase-1 (COX-1) 的抑制剂，IC50值为7.5 μM。 |
| S3926 | Forsythin | Forsythin (FOR, Phillyrin) is an active ingredient extracted from the fruit of the medicinal plant Forsythia suspensa (Thunb.) Vahl and has been shown to have antioxidant, antibacterial and antiinflammatory properties. |
| S2317 | L-(+)-Rhamnose Monohydrate | L-(+)-Rhamnose Monohydrate 是一种天然存在的脱氧糖。 |
| S3901 | Astragaloside IV | Astragaloside IV (AST-IV, AS-IV) is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It has various effect on the cardiovascular, immune, digestive, and nervous systems. AS-IV suppresses activation of p-Akt, p-mTOR, p-NF-κB and p-Erk1/2. |
| S3915 | Gracillin | Gracillin, a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica, has been reported to exert antitumor activity. |
| S3916 | Macranthoidin B | Macranthoidin B (Macranthoiside I) is a major bioactive saponin in rat plasma after oral administration of extraction of saponins from Flos Lonicerae. |
| S3920 | 7β-Hydroxylathyrol | 7β-Hydroxylathyrol (7beta-Hydroxylathyrol, 7-Hydroxylathyrol) is natural occuring product extracted from the seeds of Euphorbia lathyris L. |
| S3921 | Lathyrol | Lathyrol is a natural product that is used for cancer treatment. |
| S3931 | Ginsenoside Rd | Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively. |
| S3765 | Picroside II | Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities. |
| S3875 | Alpinetin | Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. |
| S3878 | Bavachinin | Bavachinin (7-O-Methylbavachin) ia a novel natural pan-PPAR agonist from the fruit of the traditional Chinese glucose-lowering herb malaytea scurfpea. It shows stronger activities with PPAR-γ than with PPAR-α and PPAR-β/δ (EC50 = 0.74 μmol/l, 4.00 μmol/l and 8.07 μmol/l in 293T cells, respectively). |
| S3881 | Scopoletin | Scopoletin (Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid) is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities. |
| S3883 | Protopine | Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities. |
| S3884 | Jatrorrhizine | Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE. |
| S3800 | Lycorine hydrochloride | Lycorine (Galanthidine, Amarylline, Narcissine, Licorine), a natural alkaloid extracted from the Amaryllidaceae plant family, has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer. It is an HCV inhibitor with strong activity. |
| S3801 | Sodium Houttuyfonate | Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis. |
| S3804 | Alpha-Mangostin | Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING. |
| S3808 | Mangiferin | Mangiferin (Alpizarin, Chinomin, Hedysarid) is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. |
| S3810 | Scutellarin | Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide)是从中草药黄芩Scutellaria baicalensis和灯盏细辛Erigeron breviscapus中提取的主要活性类黄酮，具有许多药理作用，例如抗氧化、抗肿瘤、抗病毒和抗炎活性。Scutellarin 可以下调HCC细胞中的 STAT3/Girdin/Akt 信号传导，并抑制破骨细胞中RANKL介导的 MAPK 和 NF-κB 信号通路。 |
| S3811 | Ginsenoside Re | Ginsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc)是三七的提取物、人参中的主要人参皂苷，属于20(S)-原人参三醇组 (protopanaxatriol group)。它具有多种体外和体内作用，包括血管舒张作用，抗氧化剂，抗高血脂和血管生成作用。Ginsenoside Re 会降低 β-amyloid protein (Aβ) 并通过抑制 JNK 和 NF-κB 起到抗炎的作用。 |
| S3891 | Vincamine | Vincamine (Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan), an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain. |
| S3813 | Bakuchiol | Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities. |
| S3919 | Hederacoside C | Hederacoside C (HDC, Kalopanaxsaponin B) is one of the active ingredients in Hedera helix leaf extract (Ivy Ex.) and used to treat respiratory disorders. |
| S3837 | Echinocystic acid | Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects. |
| S3844 | Rosavin | Rosavin, a cinnamyl alcohol glycoside found in the plant Rhodiola rosea, possesses antidepressant and anxiolytic activities. |
| S3846 | Eupatilin | Eupatilin (NSC 122413), a major flavonoid from Artemisia plants, possesses various beneficial biological effects including anti-inflammation, anti-tumor, anti-cancer, anti-allergy, and anti-oxidation activity. |
| S3779 | cis-Anethole | Anethole ((Z)-Anethole, Cis-p-Propenylanisole, Cis-p-Anethole) has two isomers, the cis(Z) isomer being 15-38 times more toxic to animal than the trans(E) isomer. cis-Anethole is found in anise and Only a low level is permitted in flavours. |
| S3782 | Neomangiferin | Neomangiferin (Mangiferin 7-glucoside), a natural xanthone C-glycoside mainly obtained from the well-known traditional Chinese medicine rhizoma of Anemarrhena asphodeloides, exhibits antidiabetic activity and antiosteoporotic action. |
| S3783 | Echinacoside | Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. |
| S3777 | Gentiopicroside | Gentiopicroside (GE, Gentiopicrin), a naturally occurring iridoid glycoside, inhibits CYP2A6 and CYP2E1 with IC50 values of 21.8μg/ml and 594μg/ml, respectively in human liver microsomes, and dose not inhibit CYP2C9, CYP2D6, CYP1A2 or CYP3A4 activities. |
| S3784 | Obacunone (AI3-37934) | Obacunone (AI3-37934, CCRIS 8657), a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2. |
| S3786 | Glabridin | Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory. |
| S3787 | Picroside I | Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B. |
| S3780 | Secoisolariciresinol diglucoside | Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer. |
| S3914 | α-Hederin | α-hederin is a water-soluble pentacyclic triterpenoid saponin which has shown hemolytic and apoptotic properties. |
| S3929 | Liquiritigenin | Liquiritigenin (4',7-Dihydroxyflavanone), the most active estrogenic compound from the root of Glycyrrhizae uralensis Fisch, selectively binds to ERβ with an IC50 value of 7.5 μM and activates multiple ER regulatory elements and native target genes with Erβ but not ERα. |
| S3932 | Astilbin | Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities. |
| S3760 | Stachydrine hydrochloride | Stachydrine is isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. It has potent anti-metastatic activity and cardioprotective effects. Stachydrine hydrochloride is the major active constituent of Herba Leonuri, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities. |
| S3764 | Isoferulic Acid | Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties. |
| S3766 | Tanshinone IIA sulfonate sodium | Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen. Sodium tanshinone IIA sulfonate (STS) is a potent negative allosteric modulator of the human purinergic receptor P2X7. Sodium tanshinone IIA sulfonate (STS) inhibits the activity of CYP3A4 and store-operated Ca2+ entry (SOCE) through store-operated Ca2+ channels (SOCC) via downregulating the expression of transient receptor potential canonical proteins (TRPC). |
| S3771 | Stachydrine | Stachydrine (Proline betaine, L-stachydrine, Methyl hygrate betaine) is a quaternary ammonium derivative of proline that occurs widely in Medicago species. It is an osmoprotective compound found in urine. Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway. |
| S3773 | Tyrosol | Tyrosol (4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol) is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives. Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects. |
| S3775 | Ligustrazine hydrochloride | Ligustrazine hydrochloride (Tetramethylpyrazine, Tetrapyrazine) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities. |
| S5101 | Tabersonine hydrochloride | Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity. |
| S2318 | Lappaconitine | Lappaconitine (LC) is a natural diterpenoid alkaloid (DTA), acting as a human heart sodium channel blocker and possessing a wide range of biological activities, including anti-arrhythmic, anti-inflammatory, antioxidative, anticancer, epileptiform etc. |
| S3815 | Mogroside V | Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit). |
| S3819 | Decursinol angelate | Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas. |
| S3820 | Dehydroevodiamine hydrochloride | Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production. |
| S3825 | Glycitin | Glycitin (Glycitein-7-β-O-glucoside), a natural isoflavone isolated from legumes, has antibacterial, antiviral and estrogenic activities and may exerts preventative effects on alcoholism, cardiovascular and cerebrovascular diseases and some types of cancer. |
| S3826 | Hydroxytyrosol | Hydroxytyrosol (3,4-dihydroxyphenylethanol) is one of the main phenolic components of olive oil with excellent antioxidant, antimicrobial and anticarcinogenic activities. |
| S3827 | Royal jelly acid | Royal jelly acid (10-Hydroxy-trans-2-decenoic acid, 10H2DA) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity. |
| S3828 | Orcinol glucoside | Orcinol glucoside (OG, Sakakin) is an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn. It shows potent antioxidative and anxiolytic activities without sedative effects. |
| S3829 | Isoalantolactone | Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia. |
| S3834 | Astaxanthin | Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. |
| S3835 | Loganin | Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively. |
| S3836 | 6-Gingerol | 6-Gingerol is the active constituent of fresh ginger known to exhibit a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. |
| S3838 | Carnosic acid | Carnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries. |
| S3840 | Baohuoside I | Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway. |
| S3842 | Isoquercitrin | Isoquercitrin (Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside), a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation. |
| S3833 | Amentoflavone | Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities. |
| S5103 | lutein | Lutein (Xanthophyll, Xantofyl) is a vitamin-like carotenoid produced by plants, which contributes to the colour of some fruit and vegetables. It is a lipid-soluble antioxidant that can circulate in the plasma and confer cardioprotective, anti-inflammatory, and anti-angiogenic effects. |
| S3943 | Lycopene | Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant. |
| S3960 | Higenamine hydrochloride | Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants. |
| S3941 | Pinocembrin | Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone)是制药工业中多功能黄酮类分子，它具有很多药学活性，如抗菌、消炎、抗氧化和抗癌活性。 |
| S5104 | Tea polyphenol | Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities. |
| S3939 | 4'-Methoxyresveratrol | 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation. |
| S3940 | 3'-Hydroxypterostilbene | 3'-Hydroxypterostilbene (3'-HPT)是苦马豆和紫檀木心中的活性成分之一，可能对治疗不同类型的恶性血液肿瘤有效。3'-Hydroxypterostilbene 可通过诱导凋亡和自噬，从而有效地抑制人结肠癌细胞的生长，对COLO 205，HCT-116和HT-29 cells的IC50值分别为9.0 µM、40.2 µM和70.9 µM。3'-Hydroxypterostilbene 会抑制 PI3K/Akt/mTOR 信号通路中的p70S6K 和 p38MAPK信号通路，而激活ERK1/2, JNK1/2 信号通路。 |
| S3614 | Lupeol | Lupeol (Clerodol, Monogynol B, Fagarasterol, Farganasterol) 是一种显著的白桦脂酸型三萜烯，存在于植物、真菌和动物中，具有抗癌、抗原生动物、化学预防、消炎作用。 |
| S3747 | Levothyroxine sodium | Levothyroxine (L-T4, L-Thyroxine) 是源于甲状腺的主要激素，是甲状腺激素受体α和β的激动剂。 |
| S3668 | Thymopentin | Thymopentin (TP5) has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells. |
| S3608 | Demethylzeylasteral (T-96) | Demethylzeylasteral (T-96)是从Tripterygium wilfordii Hook F.中分离出的活性成分，能够抑制UDP-glucuronosyltransferase (UGT)的亚型UGT1A6和UGT2B7，具有免疫抑制活性。 |
| S3610 | Cordycepin | Cordycepin (3'-Deoxyadenosine) is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities. |
| S3613 | Scoparone | Scoparone (6,7-dimethoxycoumarin, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, Escoparone)是一种天然的有机化合物，是从中草药猪毛蒿中提取而来，具有抗凝、降血脂、抗氧化和抗炎作用。 |
| S3615 | Dehydrocostus Lactone | Dehydrocostus lactone (DHE)是一种天然的倍半萜内酯，抑制IKKβ活性、IκBα的磷酸化和降解、共激活子p300的招募、p50/p65 NF-κB的核转位及它们结合于COX2启动子上的能力。DHE具有抗炎、抗溃疡、抗肿瘤作用和免疫调节活性。 |
| S3616 | Asiaticoside | Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol) 是Centella asiatica（积雪草）中的主要活性成分，通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。 |
| S3606 | Fangchinoline | Fangchinoline是双苄基异喹啉类生物碱，是HIV-1的新型抑制剂，具有缓解疼痛、降低血压和抗菌活性。 |
| S4757 | Dihydrotestosterone (DHT) | Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT)是一种内源性的雄激素性类固醇和激素，是雄激素受体的激动剂，其亲和力比睾酮高2-3倍，诱导雄激素受体信号的效力比睾酮高3倍。 |
| S4752 | Corticosterone (NSC-9705) | Corticosterone (NSC-9705, 17-deoxycortisol, 11β,21-dihydroxyprogesterone)是主要的压力激素，一种肾上腺皮质类固醇，具有作为盐皮质激素和糖皮质激素的活性。 |
| S8291 | Atractylenolide I | Atractylenolide I 是A. macrocephala根茎的主要类倍半萜烯类化合物。具有广谱的药理活性，如抗炎、促消化、抗氧化作用。 |
| S4742 | Rebaudioside C | Rebaudioside C (Dulcoside B) 属于甜菊糖苷（Steviol Glycosides）家族。它是甜叶菊Stevia rebaudiana Bertoni中的天然组分，是糖尿病患者和控制碳水化合物的治疗饮食中的天然甜味剂。 |
| S4743 | Wogonin | Wogonin (Vogonin)，在植物中发现的天然活性黄酮类化合物，是CDK9的抑制剂。在抑制CDK9的浓度下，对CDK2、CDK4和CDK6没有抑制作用。也可抑制N-acetyltransferase。 |
| S4741 | Danshensu | Danshensu (Salvianic acid A)，是一种传统中药中的中草药，具有潜在的抗肿瘤和抗血管生成的效果。Danshensu 可抑制 CYP2E1 和 CYP2C9，对应的IC50值分别为36.63 μm和 75.76 μm。 |
| S4739 | Oxyresveratrol | Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene)是从Morus alba L.发现的天然化合物，对酪氨酸酶的多巴氧化酶活性具有有效抑制作用，能催化黑色素生物合成的限速步骤。 |
| S4746 | (20S)-Protopanaxadiol | 20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol)，人参皂苷在肠道的主要代谢物，是人参中的活性成分之一。20(S)-Protopanaxadiol 可在耐多种药物的癌细胞中抑制 P-glycoprotein。 |
| S4735 | Salvianolic acid B | Salvianolic acid B (Sal B, Lithospermate B, Lithospermic acid B)是一种抗氧化剂和自由基清除化合物，是从丹参中提取出来的最丰富的生物活性化合物。 |
| S8318 | Alantolactone | Alantolactone (helenin, helenine, Eupatal)，一种天然的桉烷类倍半萜内酯，能诱导activin/SMAD3信号、干扰Cripto-1/activin受体ⅡA型受体的相互作用。 |
| S4707 | Oleic Acid | 油酸 Oleic acid (Oleate, 9-Octadecenoic Acid, Elaidoic acid)是一种天然存在于多种动物和植物脂肪和油类中的脂肪酸。它常被用作制作油酸和乳液，并作为一种药物溶剂。 |
| S4722 | (+)-Catechin | (+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) 是抗氧化类黄酮，主要以(+)-catechin和(-)-epicatechin的形式存在于木本植物中。 |
| S4723 | (-)Epicatechin | (−)Epicatechin (L-Epicatechin, (-)-Epicatechol)是一种类黄酮，在可可、绿茶、红酒中常见。具有强的抗氧化、胰岛素类似作用，能改善心脏健康。 |
| S4726 | Lauric Acid | Lauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid)是饱和中链脂肪酸，在多种植物、动物油脂中都天然存在，是椰子油和棕榈仁油的主要成分。 |
| S4719 | Kynurenic acid | Kynurenic acid (Quinurenic acid, Kynurenate)是色氨酸通过犬尿氨酸途径代谢的天然代谢物，是一种广谱的兴奋性氨基酸拮抗剂。它是NMDAR, kainate receptor和AMPA receptor的拮抗剂。 |
| S4711 | Esculetin | Esculetin (Cichorigenin, Aesculetin)是在很多种天然植物产物中发现的香豆素衍生物，具有抗水肿、抗炎、抗肿瘤的生物和药理学特性，能抑制脂肪氧合酶。 |
| S4728 | 3,3'-Diindolylmethane | 3,3'-Diindolylmethane(DIM) 是indole-3-carbinol的主要消化产物，而indole-3-carbinol是十字花科蔬菜中一种潜在的抗癌物质。3,3'-Diindolylmethane(DIM) 是一种纯粹的 androgen receptor (AR) 的强拮抗剂。 |
| S4708 | Palmitoylethanolamide | Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) 是一种内源性的脂肪酸酰胺，能在体外选择性激活PPAR-α，EC50为3.1±0.4 μM。 |
| S4690 | Escin | Escin (Aescin) 是在欧洲七叶树中所发现的皂苷混合物，具有抗炎、血管收缩的、血管保护作用。 |
| S4686 | Vitamin E | Vitamin E (D-alpha-Tocopherol) 是一种脂溶性的维生素，具有有效的抗氧化特性。它是有效的过氧化氢自由基清除剂并在很多组织中，非竞争性地抑制环氧酶活性。同时通过抑制VEGF基因转录，抑制血管生成和肿瘤休眠。 |
| S4706 | Eugenol | Eugenol (4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol)是一种自然存在的香味化合物，发现于丁香油和其他植物中。Eugenol通过增加组胺释放和细胞免疫发挥其生理作用。 |
| S4539 | Salicylic acid | Salicylic acid (2-Hydroxybenzoic acid)是一种水杨酸，植物中的天然化合物，是乙烯生物合成和环氧酶活性的抑制剂。 |
| S4507 | 17-Hydroxyprogesterone | 17-Hydroxyprogesterone (17-OHP)是一种内源性孕激素，是其他类固醇激素生物合成过程中的化学中间体。 |
| S7867 | Oleuropein | Oleuropein 是一种从橄榄叶中分离出的抗氧化多酚。Oleuropein 具有抗氧化、抗炎和抗动脉粥样硬化的作用，并在体外抑制脂肪细胞的分化。Oleuropein 抑制 PPARγ 活性。Oleuropein 通过直接抑制PPARγ转录活性发挥抗脂肪形成作用。Oleuropein 还可抑制aromatase。Oleuropein 可诱导凋亡。Phase 2。 |
| S7594 | Abscisic Acid (Dormin) | Abscisic Acid (Dormin, Abscisin II)是一种植物激素，参与许多植物发育过程，调节离子平衡和新陈代谢，并且抑制植物发芽和幼苗生长。 |
| S7582 | Anacardic Acid | Anacardic Acid (6-pentadecylsalicylic Acid)是一个有效的p300及p300/CBP相关因子 histone acetyltranferases的抑制剂，也具有抗细菌和抗微生物活性，抑制前列腺素合成，并抑制酪氨酸酶和脂肪氧合酶。 |
| S8036 | Butein | Butein，一种从漆树中分离的植物多酚，可以抑制酪氨酸激酶，NF-κB，STAT3和EGFR活化。 |
| S7025 | Embelin | Embelin (Embelic Acid, NSC 91874)，从矮地茶中分离的一种醌类化合物，是一种细胞凋亡的X染色体抑止剂(XIAP)的抑制剂，无细胞试验中IC50为4.1 μM。 |
| S4033 | Sennoside A | Sennoside A (NSC 112929)，一种从大黄根茎中分离得到的刺激性泻药，在肠道中引起通便作用。 |
| S4018 | Sennoside B | Sennoside B，一种从大黄根茎中分离得到的刺激性泻药，抑制PDGF刺激的细胞增殖。 |
| S2252 | (+)-Usniacin | (+)-Usniacin (D-Usnic Acid)是在一些地衣中发现的天然存在的二苯并呋喃类衍生物。 |
| S2253 | 3-Indolebutyric acid (IBA) | 3-Indolebutyric acid(IBA)是一种植物激素，用于使许多商业植物生根园艺产品。 |
| S2424 | Hypoxanthine | Hypoxanthine是天然存在的嘌呤类衍生物，是尿酸合成的中间产物，由腺嘌呤核苷酸代谢而来，为黄嘌呤前体。 |
| S2374 | 5-hydroxytryptophan (5-HTP) | 5-Hydroxytryptophan (5-HTP, NSC-92523)，在Vitamin B6存在时，通过酶芳香族-L-氨基酸脱羧酶脱羧成羟色胺（5-hydroxytryptamine 或5-HT）。 |
| S2256 | 4-Methylumbelliferone (4-MU) | 4-Methylumbelliferone (4-MU)是透明质酸(HA)合成抑制剂，IC50为0.4 mM。 |
| S2375 | Aloin | Aloin (Barbaloin, Barbalin) 是有效的酪氨酸酶抑制剂，作用于HeLaS3细胞，IC50为97 μM。 |
| S2258 | Esculin | Esculin (Aesculin) 是一种在Horse chestnuts中发现的葡萄糖苷。 |
| S2377 | Biochanin A | Biochanin A (4-Methylgenistein) 是O-甲基异黄酮，是黄酮类的一种天然有机化合物。 |
| S2259 | Aloe-emodin | Aloe-emodin (NSC 38628, Rhabarberone) 是一种干扰素诱导剂，作用于JEV，IC50为1 μg/mL，作用于EV71，IC50为0.33 μg/mL。 |
| S3071 | Vanillin | Vanillin (FEMA 3107),香草醛,是一种食品添加剂。 |
| S2260 | Amygdalin | Amygdalin 最初从Prunus dulcis树的种子中分离的一种糖苷，也被称为苦杏仁。 |
| S2379 | Dioscin | Dioscin (Collettiside III, Saponin) 是皂苷提取的，Polygonatum Zanlanscianense Pamp分离的，抑制MDA-MB-435, H14, HL60, 和 HeLa 细胞系，IC50分别为 2.6, 0.8, 7.5, 和 4.5 μM。 |
| S2261 | Andrographolide | Andrographolide是一种Labdane类二萜，是药用植物Andrographis paniculata的主要生物活性成分 |
| S2380 | Diosmetin | Diosmetin (Luteolin 4-methyl ether)是在Spearmint, Oregano, 和许多其他植物中发现的生物类黄酮。 |
| S2262 | Apigenin (LY 080400) | Apigenin (NSC 83244, LY 080400)是一种有效的CYP2C9抑制剂，Ki为2 μM.。 |
| S2263 | Arbutin | Arbutin (Uva, p-Arbutin, β-Arbutin) 是一种酪氨酸酶 tyrosinase 抑制剂，对Monophenolase和Diphenolase的IC50值分别为0.9 mM 和 0.7 mM。 |
| S2382 | Evodiamine | Evodiamine (Isoevodiamine)是Evodiae Fructus中提取的一种生物碱。它能通过抑制IkB kinase活性抑制NF-kB的激活。 |
| S2384 | Hematoxylin | Hematoxylin (Hydroxybrazilin)易与某些金属离子，尤其是Fe（III）和Al（Ⅲ）盐，形成有色络合物。 |
| S2266 | Asiatic Acid | Asiatic acid (Dammarolic acid, Asiantic acid)是积雪草苷的糖苷配基，从植物积雪草中分离而来的，常用于伤口愈合。 |
| S2386 | Indirubin (NSC 105327) | Indirubin (NSC 105327) 是一种有效的细胞周期依赖性激酶和GSK-3β抑制剂，IC50约为 5 μM和0.6 μM。 |
| S2267 | Azomycin | Azomycin (2-Nitroimidazole) 是Nocardia mesenterica产生的抗生素。 |
| S2268 | Baicalein | Baicalein是CYP2C9和脯氨酰肽链内切酶抑制剂。 |
| S2269 | Baicalin (NSC-661431) | Baicalin (NSC-661431)是一种脯氨酰肽链内切酶抑制剂，影响GABA受体。 |
| S2389 | Naringin Dihydrochalcone | Naringin Dihydrochalcone 是一种新型甜味剂，是来自柚皮苷的一种人工甜味剂。也是一种CYP enzymes的抑制剂。 |
| S2270 | Bergenin | Bergenin (Cuscutin)是三羟基酸苷和4-O-甲基没食子酸的C-苷。 |
| S2390 | Polydatin | Polydatin (Piceid) 是从多年生草本Polygonum Cuspidatum Sieb.et Zucc的根茎提取的一种结晶组分。 |
| S2271 | Berberine chloride (NSC 646666) | Berberine chloride (NSC 646666, Natural Yellow 18)是异喹啉类生物碱的季铵盐。Berberine chloride 可激活 caspase 3 和 caspase 8，分裂 poly ADP-ribose polymerase (PARP) 和释放 cytochrome c。Berberine chloride 可降低 c-IAP1，Bcl-2 和 Bcl-XL 的表达。Berberine chloride 可通过 JNK 和 p38 MAPK 的持续磷酸化以及产生 ROS 来诱导凋亡。Berberine chloride 是一个 topoisomerase I 和 II 的双效抑制剂。Berberine chloride 也是一个潜在的自噬调节剂。 |
| S2391 | Quercetin (NSC 9221) | Quercetin (NSC 9221, Sophoretin, C.I. 75720)是蔬菜水果和白酒中的天然黄酮类化合物，是一种体外重组Sirt1蛋白的激活剂同时也是PI3K抑制剂，IC50为2.4 – 5.4 μM。Quercetin 可诱导凋亡和保护性的自噬。Phase 4。 |
| S3600 | Schisandrin B (Sch B) | Schisandrin B (Sch B)是中草药五味子(Turcz.)中含量最丰富的二苯并环辛二烯木酚素。它是一种安全的ATR和P-gp抑制剂。 |
| S2273 | β-Sitosterol | β-Sitosterol (SKF 14463, 22,23-Dihydrostigmasterol)是一种植物甾醇，与胆固醇具有相似的化学结构。 |
| S2392 | Sesamin | Sesamin (Fagarol, Fsesamin) 是从Fagara植物的树皮和芝麻油中分离的一种木脂素。 |
| S2448 | Gambogic Acid | Gambogic Acid (Guttatic Acid, Guttic Acid, Beta-Guttiferrin)激活caspases，EC50为0.78 - 1.64 μM，且完全抑制Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 和 Mcl-1，IC50分别为1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM 和 0.79 μM。 |
| S2276 | Bilobalide | Bilobalide 是一种存在于Ginkgo biloba中的有生物活性的萜内酯。 |
| S2277 | Caffeic Acid | Caffeic Acid是一种羟基肉桂酸，是一种天然存在的有机化合物。 |
| S2281 | Chrysin | Chrysin (NSC 407436) 是一种天然存在的Flavone，是由Passiflora caerulea花化学提取而来的。 |
| S2282 | Cinchonidine | Cinchonidine是一种生物碱，在有机化学中用于不对称合成。 |
| S2422 | Ipriflavone (Osteofix) | Ipriflavone (Osteofix)是小分子物质，用于抑制骨吸收。 |
| S2285 | Cryptotanshinone | Cryptotanshinone 是一种STAT3抑制剂，无细胞试验中IC50为4.6 μM，强烈抑制STAT3 Tyr705磷酸化，对STAT3 Ser727作用效果弱，对STAT1和STAT5没有作用效果。Cryptotanshinone 可诱导ROS依赖的自噬和线粒体介导的凋亡。 |
| S2423 | (S)-10-Hydroxycamptothecin | (S)-10-Hydroxycamptothecin (10-HCPT)是DNA拓扑异构酶I抑制剂，具有有效的抗肿瘤活性。 |
| S2437 | Rotundine | Rotundine是一种选择性多巴胺D1受体拮抗剂， IC50为166 nM。 |
| S2287 | Cytisine | Cytisine (Baphitoxine, Sophorine)是一种烟碱型乙酰胆碱受体激动剂。 |
| S2289 | Daidzin | Daidzin (Daidzoside, Daidzein 7-O-glucoside, Daidzein 7-glucoside)，一种植物天然有机化合物，也是一种异黄酮，是有效的、选择性的人类线粒体醛脱氢酶抑制剂，选择性抑制ALDH-I（Ki=20 nM）；而对ALDH-Ⅱ的效力至少低500倍（Ki=10 μM）。 |
| S2385 | Hordenine | Hordenine是一种苯乙胺生物碱 具有抗菌特性。 |
| S2394 | Naringenin | Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol)是来自于食用植物的一种天然的主要黄酮类化合物，有益人体健康，具有生物活性，是一种抗氧化剂，自由基清除剂，抗炎，碳水化合物代谢启动子及免疫系统的调制剂。 |
| S2292 | Diosmin | Diosmin 是一种 aryl hydrocarbon receptor (AhR) 的激动剂。Diosmin 是一种半合成Phlebotropic药物，也是一种在各种柑橘类水果中发现的类黄酮。 |
| S1973 | Cyclocytidine HCl | Cyclocytidine (NSC 145668) 是Cytarabine的前体药物，是一种嘧啶核苷类似物，抑制DNA synthesis，主要用于治疗白血病。 |
| S2296 | Enoxolone | Enoxolone (Glycyrrhetin) 是一种通过甘草酸水解得到的β-香树脂醇型五环三萜衍生物。 |
| S2395 | Rheochrysidin | Rheochrysidin (Physcione)是大承气汤的主要成分之一，用于治疗炎症。 |
| S2297 | Ergosterol | Ergosterol是甾醇，是vitamin D2的生物前体（一种维生素原）。 |
| S2396 | Salidroside | Salidroside (Rhodioloside) 是一种糖苷类化合物，作用于SACC-2细胞增殖，IC50为4.99±0.23 μg/mL。 |
| S2298 | Fisetin | Fisetin 是有效的Sirtuin活化化合物(STAC)，可以调节Sirtuin。 |
| S2397 | Palmatine chloride | Palmatine chloride 是Palmatine的盐酸盐，是一种小檗碱类生物碱。 |
| S2299 | Formononetin | Formononetin (Formononetol, Biochanin B)是Astragalus根部的一种植物雌激素，是O-甲基异黄酮。 |
| S2398 | Coenzyme Q10 (CoQ10) | Coenzyme Q10 (CoQ10) 组成电子传递链，并参与细胞有氧呼吸。 |
| S2300 | Ferulic Acid | Ferulic Acid (Fumalic) 是一种羟基肉桂酸，是在Ferula assafoetida L或Ligusticum chuanxiong中发现的一种有机化合物。Ferulic acid 是一种新型的 fibroblast growth factor receptor (FGFR) 抑制剂，对FGFR1和FGFR2的IC50分别为3.78 μM和12.5 μM。 |
| S2399 | Dihydromyricetin | Dihydromyricetin (Ampelopsin, Ampeloptin)是具有良好性能的天然抗氧化剂。 |
| S2301 | Genistin (Genistoside) | Genistin (Genistoside, Genistine, Genistein 7-glucoside, Genistein glucoside)是在很多可以食用植物（如大豆和野葛）中发现的一种异黄酮。Genistin 通过调节 Estrogen Receptor α (ERα) 信号传导途径来减弱细胞生长并促进凋亡细胞死亡。 |
| S2400 | Rheic Acid | Rhein (Monorhein, NSC 38629, Rheinic) 是Rhubarb的组成部分，是从Rheum coreanum Nakai新鲜根茎分离得到的，具有抗炎和抗肿瘤活性。Rhein 是一种FTO (mRNA N6-methyladenine demethylase)的抑制剂，并且还可抑制 AlkB repair enzymes。 |
| S2401 | Sodium Danshensu | Sodium Danshensu是丹参素的单钠盐，是从Salvia miltiorrhiza Bge中分离的天然酚酸，是咖啡酸衍生物。 |
| S2303 | Gossypol Acetate | Gossypol Acetate (Gossypol Acetic acid, Pogosin, AT101) 是多酚醛，可渗透细胞，是一些脱氢酶（如乳酸脱氢酶、NAD-linked enzymes）的抑制剂。 |
| S2402 | Cyclovirobuxine D | Cyclovirobuxine D (Cyclovirobuxin D, Cyclovirobuxine, Bebuxine, CVB-D) 是从Buxus microphylla中提取的活性化合物，用于治疗急性心肌缺血。 |
| S2304 | Gramine | Gramine (Donaxine) 是一种从巨型芦苇中分离出的天然吲哚生物碱，是一种活性脂联素受体（AdipoR）激动剂，对AdipoR2和AdipoR1的IC50分别为3.2 µM和4.2 µM。 禾胺也是人和小鼠 β2-Adrenergic receptor (β2-AR) 激动剂。 |
| S2403 | Tetrandrine (NSC-77037) | Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine)是来源于千金藤根部的一种双苯基异喹啉，一种钙离子通道抑制剂。 |
| S2306 | Gynostemma Extract | Gynostemma Extract (Gynostemma Pentaphyllum, Gypenoside)是一种从Gynostemma pentaphyllum提取而得的皂甙。 |
| S2308 | Hesperetin | Hesperetin是一种生物类黄酮，更具体而言，是一种二氢黄酮。 |
| S2309 | Hesperidin | Hesperidin (Cirantin)是在柑橘类水果中广泛存在的黄酮苷。 |
| S2404 | Isoliquiritigenin | Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一种类黄酮，能抑制醛糖还原酶，IC50为320 nM。具有抗肿瘤活性。 |
| S2405 | Sophocarpine | Sophocarpine 是人类ether-à-go-go相关基因(HERG)抑制剂，IC(50)为0.2 mM。 |
| S2311 | Hyodeoxycholic acid (HDCA) | Hyodeoxycholic (HDCA, NSC 60672) acid 是一种次要的胆汁酸，是肠道细菌的代谢产物之一。 |
| S2406 | Chrysophanic Acid | Chrysophanic Acid (Chrysophanol) 是Dianella longifolia中的一种天然蒽醌，是一种EGFR/mTOR通道抑制剂。 |
| S2312 | Icariin | Icariin是一种cGMP特异性的PDE5抑制剂，IC50为0.432 μM，作用于PDE5比作用于PDE4选择性高167倍。 |
| S2407 | Curcumol | Curcumol是常见的传统中药，具有抗肿瘤活性。 |
| S2313 | Indole-3-carbinol | Indole-3-carbinol是通过降解硫代葡萄糖酸盐芸苔葡萄糖硫苷而来的,广泛存在于十字花科蔬菜中。它能够抑制NF-κB和IκBα激酶的激活。 |
| S2314 | Kaempferol (NSC 407289) | Kaempferol (NSC 407289, Robigenin)是一种黄酮，是ERRα和ERRγ的反向激动剂。抑制topoisomerase I催化的DNA再连接和fatty acid synthase的活性。 |
| S1450 | Nanchangmycin | Nanchangmycin是一种聚醚抗生素，与Dianemycin结构相似，非常有效地防治广谱的有害线虫和昆虫，而对哺乳动物和植物没有作用效果。 |
| S2316 | Kinetin | Kinetin (6-Furfuryladenine) 是一种细胞分裂素，是一类植物激素，促进细胞分裂。通常用于植物组织培养，诱导愈伤组织形成（与生长素联用），且诱导再生芽的发生。 |
| S2319 | Limonin | Limonin又称Limonoate D-ring-lactone 和 Limonoic acid di-delta-lactone，化学上属于Furanolactone类化合物。 |
| S2415 | Astragaloside A | Astragaloside A是从黄芪中分离的一种纯化的皂苷，广泛应用于治疗心血管疾病。 |
| S2321 | Magnolol | Magnolol (NSC 293099) 是一种在Houpu magnolia (Magnolia officinalis) 树皮中发现的生物活性化合物。它能抑制TNFα诱导的NF-KB的激活。 |
| S2322 | (+)-Matrine | (+)-Matrine是一种在植物Sophora属中发现的生物碱，具有多种药理作用，包括抗癌作用，是κ阿片受体激动剂。 |
| S3032 | Bindarit (AF 2838) | Bindarit (AF 2838) 是天然化合物，具有特定抗炎活性，因为选择性抑制炎症趋化因子亚家族，包括单核细胞趋化蛋白MCP-1/CCL2, MCP-3/CCL7, 和 MCP-2/CCL8。 |
| S2326 | Myricetin | Myricetin, 一种具有抗氧化和抗肿瘤活性的天然黄酮，是新型的MEK1抑制剂，抑制JB6 P+小鼠表皮细胞的转化。它还能抑制PI3Kγ，Kd=0.17 μM。 |
| S2327 | Myricitrin | Myricitrin (Myricitrine) 是一种化学化合物，可从Myrica cerifera (Bayberry属, 小乔木，原产于北美)的根皮中分离得到。 |
| S2439 | Guanosine | Guanosine是一种嘌呤核苷。 |
| S2329 | Naringin | Naringin (Naringoside) 是一种黄酮苷，是葡萄柚中的主要的类黄酮，具有柚子汁的苦味。具有抗氧化，降血脂，抗肿瘤活性，并且对cytochrome P450有抑制作用。 |
| S2333 | Nobiletin (NSC 76751) | Nobiletin (NSC 76751, Hexamethoxyflavone)是O-甲基黄酮，是从柑橘果皮如橘子分离的一种黄酮类化合物。具有抗炎和抗肿瘤活性。 |
| S2334 | Oleanolic Acid | Oleanolic Acid (Caryophyllin)是一种天然存在的三萜类，广泛分布于食用和药用植物，与桦木酸相关，具有相对无毒的，抗肿瘤，保肝，及抗病毒的特性。 |
| S2335 | Oridonin (NSC-250682) | Oridonin (Isodonol, Rubescenin, NSC-250682) 是从Rabdosia rubescens中分离的对映贝壳杉烷二萜,是一种具有抗肿瘤、抗细菌和抗感染效果的传统中药。Oridonin 抑制AKT1 和 AKT2的激酶活性，对应的IC50值分别为8.4 μM 和 8.9 μM。 |
| S2336 | Orotic acid (6-Carboxyuracil) | Orotic acid (6-Carboxyuracil) 是杂环化合物，是一种酸。 |
| S2337 | Osthole | Osthole 是一种香豆素类化合物。 |
| S2338 | Oxymatrine | Oxymatrine (Matrine N-oxide)是一种从Sophora flavescens的根部分离的喹唑啉生物碱，具有抗炎症、抗纤维化、抗肿瘤活性，抑制iNOS表达和TGF-β/Smad通路。被用于治疗病毒性肝炎、癌症、病毒性心肌炎、胃肠出血和皮肤疾病。 |
| S2339 | Paeonol | Paeonol (Peonol) 是从中草药牡丹皮和Cynanchum paniculatum中提取的主要成分。 |
| S3603 | Betulinic acid | Betulinic acid (ALS-357, Lupatic acid, Betulic acid)是一种天然的五环三萜类化合物，具有抗病毒，抗疟药，抗发炎和抗肿瘤的特性。Betulinic acid也是 NF-kB 的活化剂。Phase 1/2 |
| S2341 | (-)-Parthenolide | (-)-Parthenolide, Nuclear Factor-κB抑制剂，可特异性地耗尽HDAC1蛋白，而不影响其他I/II类 HDACs。促进MDM2的泛素化并激活p53的细胞功能。 |
| S2343 | Phlorizin | Phlorizin (Phloridzin) 是有毒的2'-葡萄糖苷根皮素，属于二氢查尔酮，是一种黄酮类化合物。Phlorizin 是一种非选择性的 SGLT 的抑制剂，对hSGLT1 和 hSGLT2的Ki值分别为300 nM 和 39 nM。Phlorizin 也是 Na+/K+-ATPase 的抑制剂。 |
| S3604 | Triptolide (PG490) | Triptolide (PG490, NSC 163062)是一种三环氧二萜类化合物,是从中草药雷公藤中提取的免疫抑制剂。它是一种NF-κB抑制剂，抑制NF-κB转录活性，破坏p65/CBP的相互作用，减少p65蛋白。Triptolide (PG490) 可抑制 heat shock transcription factor 1 (HSF1) 的反式激活。Triptolide 可抑制 MDM2 并通过一个p53非依赖性通路来诱导凋亡。 |
| S2344 | Piperine | Piperine (1-Piperoylpiperidine) 是一种生物碱，是造成黑胡椒和长胡椒辛辣的原因，也用于一些传统医学领域，且作为杀虫剂。 |
| S2346 | Puerarin | Puerarin (Kakonein) 是一种5-HT2C受体和苯二氮位点拮抗剂。 |
| S2347 | Quercetin Dihydrate | Quercetin (Sophoretin) 是一种多酚类黄酮，存在于多种植物性食品中，例如苹果，洋葱，浆果和红酒，由于其神经系统和抗癌作用而被用于许多不同的文化中。Quercetin (Sophoretin) 作为天然类黄酮，是重组SIRT1和PI3K抑制剂的刺激物，对PI3Kγ，PI3Kδ和PI3Kβ的IC50分别为2.4μM，3.0μM和5.4μM。 |
| S2349 | Rutaecarpine | Rutaecarpine (Rutecarpine) 是从 Evodia rutaecarpa和相关草药中分离的indolopyridoquinazolinone生物碱。是一种新型的COX2抑制剂。 |
| S2350 | Rutin | Rutin (Rutoside)是在许多植物中发现的一种黄酮苷，包括Buckwheat; Tobacco; Forsythia; Hydrangea; Viola, 等。 |
| S2351 | Salicin | Salicin (Salicoside, Salicine)是一种醇-β-糖苷，含有D-葡萄糖。是柳树皮产生的一种抗炎剂。它是一种天然的、非选择性的COX1和COX2抑制剂。 |
| S2354 | Sclareol | Sclareol 是一种芳香化合物，在Clary sage(Salvia sclarea)中发现而因此命名，被归类为双环二萜醇。 |
| S2355 | Sclareolide | Sclareolide (Norambreinolide) 是一种倍半萜内酯天然产物，来源于各种植物，包括Salvia sclarea, Salvia yosgadensis, 和 cigar tobacco。 |
| S2356 | Shikimic Acid | Shikimic acid (Shikimate) 通常所知的是其阴离子形式Shikimate，在植物和微生物中，是一种重要的生化中间体。 |
| S2357 | Silibinin (NSC 651520) | Silibinin (NSC 651520, Silybin, Silibinin A, Silymarin I, Flavobin)是Silymarin的主要活性成分。 |
| S2358 | Silymarin | Silymarin (Silybin B)是一种强效的新型自由基清除剂，用于治疗急性脑梗死患者。 |
| S2359 | Sinomenine | Sinomenine (Cucoline, Kukoline) 是一种传统中草药，用于治疗风湿病和关节炎。 |
| S2361 | Stigmasterol | Stigmasterol 是一种不饱和植物甾醇，具有抗癌，解热，抗炎和免疫调节作用。 |
| S2362 | Synephrine | Synephrine (Oxedrine)是从苦橘及其他柑橘属植物中提取的一种不饱和的植物甾醇，常用于减肥。 |
| S2363 | Tangeretin | Tangeretin (Tangeritin)是一种柑橘类黄酮。 |
| S2364 | Tanshinone I | Tanshinone I 由丹参分离而来的。 |
| S2365 | Tanshinone IIA | Tanshinone IIA (Tanshinone B) 是丹参和Salviae miltiorrhizae Radix中最丰富的二萜醌类，用于治疗心血管疾病和炎症性疾病。是天然的monoacylglycerol lipase抑制剂。 |
| S2366 | Taxifolin (Dihydroquercetin) | Taxifolin(Dihydroquercetin)是一种二氢黄酮醇类，是一种黄酮类化合物。是I型VEGFR2 kinase的抑制剂。 |
| S2368 | Theobromine | Theobromine (3,7-Dimethylxanthine)是黄嘌呤生物碱，作为一种支气管扩张剂，血管扩张剂。 |
| S2371 | Vanillylacetone | Vanillylacetone (NSC 15335) 在化学结构上与其他香料，如Vanillin 和 Eugenol类似，用来作为一种香味味添加剂。Vanillylacetone (Zingerone) 可减轻氧化应激和炎症，下调NF-κB介导的信号通路。Zingerone 充当抗有丝分裂剂，并抑制神经母细胞瘤细胞的生长。 |
| S2372 | Xanthone | Xanthone (Genicide)是一种有机化合物，可以由加热水杨酸苯酯制备而得到。 |
| S2373 | Yohimbine HCl | Yohimbine (Antagonil) 是一种瞳孔放大剂，用于治疗阳痿，也是一种春药。 |
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