天然产物

天然产物库2726种天然产物的独特集合,可用于高通量筛选和高内涵筛选。
目录号 产品名 产品描述
S0922 Salvianolic acid C Salvianolic acid C是一种非竞争性的细胞色素P4502C8 (Cytochrome P4502C8, CYP2C8)抑制剂和细胞色素P45022J2(Cytochrome P45022J2, CYP2J2)的中度混合抑制剂。
E0250 Artemitin

Artemitin, a significant flavonol compound existing in <i>Laggera pterodonta</i> (DC.) Benth., <i>Artemisia rupestris</i> L, etc., possesses bioactivities of antioxidative, anti-inflammatory and antiviral.

S3243 Zeaxanthin Zeaxanthin是一种类胡萝卜素醇,参与叶黄素循环,激活外在凋亡途径,诱导葡萄膜黑色素瘤细胞凋亡,IC50 值为40.8 µM。
E3540 Grapefruit Extract Grapefruit Extract是葡萄柚(Citrus paradisi)的提取物,可用于抗炎、免疫等研究。
E3319 Grifola frondosa Extract Grifola frondosa Extract是灰树花(Grifola frondose)的提取物,可用于肿瘤和新陈代谢的研究。
E2748 EGCG Octaacetate EGCG Octaacetate(AcEGCG)是表没食子儿茶素-3-没食子酸酯 (epigallocatechin-3-gallate, EGCG) 的前药。EGCG具有抗氧化、抗有丝分裂和抗血管生成特性。
E2438 Ginsenoside Rg3 Ginsenoside Rg3是一种存在于人参(Panax ginseng)和三七(Panax japonicus var.)中的人参皂苷,主要用于肿瘤疾病的研究。
E3570 Artemisia annua Extract 青蒿提取物是青蒿(artemisia annua)的提取物,具有抗病毒活性。
E0657 Rubiadin 1-methyl ether Rubiadin-1-methyl ethe是一种从巴戟天(Morinda officinalis How)根中分离得到的天然蒽醌类化合物,可通过阻断NF-κB通路抑制破骨细胞的骨吸收,有望成为预防和治疗过度骨吸收导致的骨病的药物。
E2693 Phycocyanobilin Phycocyanobilin (PCB)是一种开链四吡咯发色团,共价键合到 C-藻蓝蛋白(C-Phycocyanin, C-PC)的两条多肽链上,C-藻蓝蛋白是螺旋藻(Spirulina platensis)中最具代表性的胆蛋白。其保护细胞的机制包括减少氧化应激损伤,这可能有助于其治疗神经退行性疾病的临床疗效。
S8989 Xanthatin Xanthatin是一种从中药苍耳(Xanthium strumarium)叶子中分离得到的倍半萜内酯,可抑制核因子kappa-B (nuclear factor kappa-B, NF-κB)、丝裂原活化蛋白激酶(mitogen-activated protein kinase, MAPK)以及信号转导和转录激活因子(signal transducer and activator of transcription, STATs)信号通路
E0599 Arecaidine hydrochloride Arecaidine hydrochloride是槟榔果(Areca catechu)的一种成分,可抑制GABA和β-丙氨酸的吸收,但不抑制甘氨酸的吸收。
S0563 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel)是紫杉醇的衍生物,也是天然存在的木糖苷,从Taxus chinensis中分离出来,它可以引起PC-3细胞明显的有丝分裂停滞,并上调促凋亡蛋白Bax和Bad的表达,以及下调抗凋亡蛋白Bcl-2和Bcl-XL的表达,从而导致线粒体膜通透性的紊乱和caspase-9的激活。
E3387 Sophora flavescens Extract Sophora flavescens Extract (Sophora angustifolia root Extract)是从中药苦参(Sophora flavescens Aiton)中提取的。
E1138 CQ31 CQ31是一种小分子,可选择性地激活半胱天冬酶活化和募集结构域8 (caspase activation and recruitment domain-containing 8, CARD8)
E3682 Pseudostellaria heterophylla Extract Pseudostellaria heterophylla Extract(Radix Pseudostellaria Extract) 是从太子参(Pseudostellaria heterophylla)中提取的有效成分,可用于治疗糖尿病。
E0769 Ginsenoside Rh4 Ginsenoside Rh4是中药人参的重要有效成分,已被证明能够抑制Wnt/β-Catenin、JAK2/STAT3、TGF-β/Smad2/3等信号通路。
E2683 Ursodeoxycholic acid sodium Ursodeoxycholic acid sodium是一种天然胆汁酸的钠盐,用于治疗多种肝脏和胃肠道疾病。
E0671 Deacetylasperulosidic acid Deacetylasperulosidic acid是Morinda citrifolia果实的主要植物化学成分,具有提高超氧化物歧化酶(superoxide dismutase, SOD)活性的抗氧化活性,以及抑制诱导仓鼠卵巢细胞和小鼠染色体畸变的抗致裂活性。
S8233 Prodigiosin Prodigiosin是一种由多种细菌产生的天然红色素,可抑制Wnt/β-catenin信号通路
S6975 N-Vanillyldecanamide N-Vanillyldecanamide是一种从辣椒(Capsicum annuum)果实中分离得到的辣椒素,能以剂量依赖性方式显著降低莴苣(Lactuca sativa)幼苗的自由基长度。
E3199 Petasites Japonicus Extract Petasites Japonicus Extract至少部分通过Runt相关转录因子2 (Runt-related transcriptional factor 2, RUNX2)和Osterix调控成骨细胞分化,提示P. Japonicus叶水提物可能是预防和治疗骨质疏松症的替代疗法。
E0758 Silydianin

Silydianin is an active constituent of <i>Silybium marianum</i>, with exhibit anti-collagenase, antitumor and anti-elastase activities.

E2548 N-(p-Coumaroyl) Serotonin N-(p-Coumaroyl) Serotonin (p-coumaroylserotonin)是一种从红花种子中分离出来的多酚,具有抗氧化、抗动脉粥样硬化和抗炎作用,能够抑制PDGF诱导的PDGF受体磷酸化和肌浆网Ca2+释放。
E2274 Hexahydrocurcumin

Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor.

E0477 N-Caffeoyl O-methyltyramine N-Caffeoyl O-methyltyramine是从Cuscuta reflexa中分离得到的一种生物碱,对α-葡萄糖苷酶(α-glucosidase)具有较强的抑制活性,IC50为103.58 μM。
E2833 1,5-Anhydro-D-glucitol 1,5-Anhydro-D-glucitol (1,5-Anhydroglucitol, 1,5-AG)是一种天然存在的单糖,普遍存在于几乎所有的食物中,可为糖尿病(diabetes mellitus, DM)的早期预测和早期筛查提供可靠的依据。
E2354 Valepotriate Valepotriate从Valeriana jatamansi Jones中分离一种不稳定的环烯醚萜,通过显著增加GABAA、谷氨酸脱羧酶65 (glutamic acid decarboxylase 65)和Bcl-2的表达,以及降低caspase-3表达发挥抗癫痫作用。
E2641 trans-Chalcone Trans-Chalcone是类黄酮的主干,也是一种有效的脂肪酸合酶(fatty acid synthase, FAS)IC50为17.1 μg/mL,以及α-淀粉酶(α-amylase)抑制剂,可引起乳腺癌细胞系MCF-7的细胞周期阻滞并诱导细胞凋亡,发挥抗真菌和抗癌活性。
E0738 Gipsoside Gypenoside是一种来自gypsophila paniculata L.的三萜皂苷。
E0831 Pseudocoptisine chloride Pseudocoptisine chloride (Isocoptisine chloride)是一种分离自Corydalis Tuber具有苄基异喹啉骨架的季生物碱,抑制乙酰胆碱酯酶(acetylcholinesterase, AChE)活性,IC50为12.8 μM,具有抗炎和抗健忘的作用。
E3505 Hibiscus syriacus flower Extract
E3503 Papaya Leaf Extract
E3684 Semen Persicae Extract
E3685 Ampelopsis grossedentata Extract
E3686 60% Garcinia cambogia Extract Garcinia cambogia Extract (60%)从藤黄Garcinia cambogia果实中提取。藤黄提取物含有丰富的柠檬酸的衍生物-羟基柠檬酸(HCA)。藤黄提取物对减肥有效,并已被用作膳食补充剂。
E3687 Radix Actinidiae Extract
E3725 Sapindus saponaria Linnaeus nutshell Extract (40%)
E3726 Sapindus saponaria Linnaeus nutshell Extract (70%)
E3727 Daphne genkwa Sieb.et Zucc. Extract
E3728 Brassica rapa Extract
E3729 Ulmus macrocarpa Hance seeds Extract
E3730 Tetradium ruticarpum fruits Extract
E3731 Chinese Gallnut Extract
E3732 Cortex Acanthopanacis Senticosus Extract
E3733 Faeces Trogopterori Extract
E3734 Schisandrae Chinensis fructus Extract Schisandrae Chinensis fructus Extract来源于五味子,即植物五味子Schisandra chinensis (Turcz.) Baill.的干燥成熟果实。五味子主要用于治疗烦躁、心悸、失眠。五味子及其活性成分在神经系统疾病中具有保护作用,包括脑血管疾病、神经退行性疾病或抑郁症。
E3735 Ficus hirta Vahl Extract
E3736 Gymnema sylvestre Extract
E3752 Abrus precatorius Bean Extract
E3773 Marasmius Extract
E3778 Magnoliae Flos Extract
E3822 Coix Lacryma-Jobi Seed Extract Coix lacryma-jobi seed Extract从薏米Coix lacryma-jobi L.中提取。薏米具有抗炎、降血糖、降低血清中脂质成分含量和降胆固醇活性。
E3837 Citrus Maxima Peel Extract
E3647 Pyrrosiae Folium Extract
E3041 Alpiniae Katsumadai Extract
E3061 Castor Bean Extract Castor Bean Extract从蓖麻Ricinus communis中提取,常用于治疗炎症性皮肤病、疖疮、痈、感染袋(脓肿)、中耳炎症和偏头痛。
E3063 Pygeum Topengii Bark Extract
E3123 Rhubarb Extract Rhubarb Extract提取自大黄Rheum palmatum L./Rheum officinale,其中一些植物化学物质可以促进某些参与肠道屏障功能的细菌性别,因此参与调节与急性酒精摄入相关的肝脏疾病的易感。
E3127 Rice Flour Extract Rice Flour Extract是从米粉(Oryza sativa) 中提取的,它含有胆碱且不含麸质,有助于肝脏健康,对患有乳糜泻的人来说是安全的。
E3129 Garlic Extract (1%)
E3166 Fermented Blank Bean Extract Fermented Blank Bean Extract是从发酵的菜豆Phaseolus vulgaris L.中提取的,有助于保护人类的消化道,主要是结肠。
E3167 Amomum Kravanh Fruit Extract Amomum Kravanh Fruit Extract提取自白豆蔻Amomum kravanh Pierre ex Gagnep的果实,其精油具有显著的抗氧化活性、抗DNA损伤的保护作用和清除亚硝酸根的活性。
E3174 Eucommia Extract (Bark, Branch and Leaf) 杜仲提取物是从原产于中国的稀有滋补药材杜仲(Eucommiae Cortex)的树皮、枝叶中提取的,对治疗高血压有很好的疗效。
E3201 Honey Extract Honey extract是从蜂蜜(mel)中提取的,由于其抗菌性能在中药中被广泛使用。
E3221 Downy Rosemyrtle Root Extract Downy Rosemyrtle Root Extract提取自中药甘草(Rhodomyrtus tomentosa (Ait.) Hassk.)。
E3289 Knoxia Valerianoides Extract
E3365 Weigela Grandiflora Fortune Extract
E3392 Balsam Pear Extract
E3458 Ilex Paraguariensis Extract
E3485 Matcha Powder
E3507 Rose-of-Sharon Seed Extract
E3521 Auricledleaf Swallowwort Root Extract
E3544 Cattail Pollen Extract
E3759 Periploca Sepium Extract
E3764 Rose Pelargonium Leaf Extract
E3847 Fructus Akebiae Extract
E3522 Achyranthes bidentata root Extract
E3523 Antrodia cinnamomea Extract
E3524 Oregano Extract
E3525 Origanum vulgare leaf Extract
E3526 Clematis apiifolia Extract
E3527 Glossy privet fruit Extract
E3528 Parsley Extract
E3529 Achillea millefolium Extract
E3530 Boat-fruited sterculia seed Extract
E3532 Wedelia Extract
E3533 Loquat leaf Extract
E3534 Hops Extract
E3535 Japanese ardisia Extract
E3536 Pleurotus ostreatus Extract
E3537 Apple cider vinegar Extract
E3538 Apple Extract
E3539 Grape skin Extract
E3541 Grapefruit Seed Extract
E3543 Dandelion Extract
E3545 Pu-erh tea Extract
E3547 Extract of Scandent Schefflera Stem and Leaf
E3548 Chia seed Extract
E3549 Qamgur Extract
E3550 Philippine flemingia root Extract
E3551 Stephania Extract
E3552 Euphorbia lathyris Extract
E3553 Climbing groundsel Extract
E3554 Rhizoma homalomenae Extract
E3555 Acmella oleracea Extract
E3556 Pharbitis Extract
E3557 Radix Peucedani Extract
E3558 Euryale ferox Extract
E3559 Radix rubiae Extract
E3560 Incised notopterygium rhizome Extract
E3561 Polygonum fagopyrum seed Extract
E3563 Eggplant Extract
E3564 Celery Extract
E3565 Celery seed Extract
E3566 Largeleaf Gentian Root Extract
E3567 Ash bark Extract
E3568 Natural indigo Extract
E3569 Caulis sinomenii Extract
E3571 Green Walnut Husk Extract
E3572 Green Tangerine peel Extract
E3580 Ginseng Extract 人参是最广泛使用的草药之一,因为它被认为可以改善精力、身体和情绪健康和福祉。
E3645 Pomegranate seed Extract
E3646 Selaginella Doederleinii Extract
E3648 Pyrrosia lingua Extract
E3649 Centaurea cyanus Extract
E3650 Diospyroskaki leaf Extract
E3651 Lycopodiastrum casuarinoides Extract
E3652 Rehmanniae radix praeparata Extract
E3654 Althaea rosea Extract(root)
E3655 Althaea rosea Extract(leaves)
E3656 Dichroa febrifuga Extract
E3657 Salvia japonica Extract
E3659 Silybum mariamum Extract
E3660 Polypodiodes niponica Extract
E3661 Prunus persica Extract
E3662 Buffalo Horn Extract
E3663 Retinerus luffae Fructus Extract
E3664 Luffa Cylindrica Stem Extract
E3665 60% Yucca schidigera Extract
E3666 Chloranthus helostegius Extract
E3667 Pine pollen Extract (flower)
E3668 Pine pollen Extract (flower bud )
E3669 Pine Nodular Branch Extract
E3670 Pine Bark Extract Pine Bark Extract is extracted 提取自松树的树皮。松树皮提取物富含生物类黄酮,主要是抗氧化剂原花青素。松树皮提取物可用于预防或治疗与氧化应激相关的各种慢性病。
E3671 Mesembryanthemum spectabile Extract
E3672 Pine needles Extract
E3673 Pine nuts Extract
E3674 Caesalpinia sappan Extract
E3676 Prunus cerasus Extract
E3677 Semen Ziziphi Spinosae Extract
E3678 Vitex agnus-castus Extract
E3679 Semen aesculi Extract
E3680 Aesculus chinensis Bunge fruits Extract
E3681 Cynomorium Songaricum Extract
E3683 Santalum album Extract
E3444 Spirulina Extract
E3445 Hibiscus sabdariffa flower Extract
E3446 Chinese Starjasmine stem Extract
E3447 Air-Plant herb Extract
E3449 Green tea Extract
E3450 Phaseolus radiatus seed Extract
E3451 Mung bean peel Extract
E3452 Green Coffee bean Extract
E3453 Gnetum parvifolium Extract
E3454 Verbena herbs Extract
E3455 Puff-ball Extract
E3456 Purslane Extract
E3459 Malan Extract
E3460 Bones of Cervus elaphus’ Extract
E3462 Coriaria Root Extract
E3463 Masson pine needle Extract
E3464 Maca extract
E3465 Radix Ophiopogonis Extract
E3466 Barley grass Extract
E3467 Malt fruit Extract
E3468 Chasteberry Extract
E3470 Mango leaf Extract
E3472 Spicate clerodendranthus Extract
E3473 Ternate buttercup root Extract
E3474 Fructus Chebulae Extract
E3475 Coleus forskohlii Extract
E3477 Rose hip Extract
E3482 Myrtle Extract
E3483 Bee flower Extract
E3486 Jasmine flower Extract
E3488 Fucus vesiculosis Extract
E3489 Cuttlefish grass Extract
E3487 Ecliptae Herba Extract
E3490 Peony flower Extract
E3491 Paeonia suffruticosa root bark Extract
E3492 Vitex negundo seed Extract
E3493 Oyster Extract
E3494 Oyster Shell Extract
E3495 Oyster Peptide 牡蛎肽是将肽分子生物技术运用于牡蛎加工过程,经酶解制成牡蛎肽。这种制作方法形成的小分子低聚肽,完全保留了牡蛎原有的维生素、微量元素和牛磺酸等营养成份,使富含核酸的牡蛎在人体摄入后比单一氨基酸或蛋白质吸收更快,更容易被机体吸收
E3497 Momordicae Semen Extract
E3498 Pigeon pea leaves Extract
E3484 Ashitaba Extract
E3480 Rosemary Extract
E3478 Rose Extract
E3476 Myrrh Extract
E3448 Chinese Astilbe rhizome Extract
E3469 Cranberry Extract
E3499 Basella rubra Extract
E3500 Agaric Extract
E3501 Hibiscus mutabilis flower Extract
E3502 Papaya Extract
E3504 Oroxylum indicum seed Extract
E3506 Hibiscus bark Extract
E3508 Magnolia Obovata Extract
E3509 Akebia quinata Extract
E3510 Costustoot Extract
E3512 Milk thistle Extract
E3513 Pumpkin seed Extract
E3514 Burdock root Extract
E3515 Great Burdock Achene Extract
E3516 Beautiful millettia root Extract
E3517 Ox-gall Extract
E3518 Daphniphyllum calycinum Extract
E3519 OX liver Extract
E3520 Beef tendon grass Extract
E3200 Bee Pollen Extract
E3203 Hibiscus Flower Extract 芙蓉花提取物是从木芙蓉(Hibiscus mutabilis)的花中提取的,由于其抗氧化和降血脂作用,具有许多药用和抗癌特性。
E3204 Citri Sarcodactylis Fructus Extract
E3206 Spirodelae Herba Extract
E3207 Blighted Wheat Extract
E3210 Rubi Fructus Extract
E3212 Prunus Humilis Bunge Extract
E3213 Glycyrrhizae Rhizoma Extract Glycyrrhizae Rhizoma Extract 提取自中药甘草(Glycyrrhizae Rhizoma)。
E3214 Nardostachyos Rhizoma Extract
E3215 Kansui Radix Extract
E3216 Citrus Extract Citrus Extract是从柑橘(Citrus reticulata Blanco)的果实中提取的,可用作防癌食品添加剂和抗癌剂。
E3217 Penthorum Chinense Pursh Extract
E3218 Zingiberis Rhizoma Extract
E3219 Flos Ascheri Extract
E3222 Sedum Aizoon Extract Sedum Aizoon Extract是从高钙菜(Sedum Aizoon)中提取的,它对从海鲜中分离出的腐败希瓦菌具有显著的抗菌活性。
E3223 Alpiniae Officinarum Rhizoma Extract
E3224 Puerariae Lobatae Radix Extract Puerariae Lobatae Radix Extract是从中药葛根(Puerariae Lobatae Radix)中提取的,具有抗氧化作用。
E3225 Pueraria Flower Extract Pueraria Flower Extract是从中药葛花(Pueraria lobata(Willd.)Ohwi)中提取的。
E3226 Devil's Claw Extract
E3340 Jiao San Xian Extract Jiao San Xian Extract是从焦三仙即焦麦芽(Hordeum vulgare L.)、焦山楂(Crataegus pinnatifida Bge.)和焦神曲中提取的。
E3354 Camellia nitidissima Extract Camellia nitidissima Extract是从金花茶Camellia chrysantha中提取的,这是一种潜在的抗肥胖的益生元营养物质,可以防止体重增加,改善肥胖相关的血脂异常和高血糖,抑制肝脏脂肪积累,调节肠道菌群。
E3355 Cinchona Extract Cinchona Extract从金鸡纳中提取,用于治疗疟疾。
E3356 Witch hazel Extract Witch hazel Extract是从植物金缕梅(Hamamelis mollis Oliver )中提取的。
E3357 Lysimachia christinae Hance extract Lysimachia christinae Hance extract是从金钱草(Lysimachia christinae Hance)中提取的,它通过影响肠道菌群来预防小鼠胆固醇结石。
E3358 Rhizoma fagopyri dibotryis Extract
E3360 Lonicera japonica Extract Lonicera japonica Extract (Japanese honeysuckle Extract)源自金银花 Lonicera japonica,即日本忍冬(Japanese honeysuckle),具有解热、抗生素、抗氧化和抗炎活性。
E3361 Calendula officinalis flower Extract
E3362 Enoki mushroom Extract
E3363 Decumbent Bugle Herb Extract Decumbent Bugle Herb Extract提取自中药筋骨草(Ajuga ciliata Bunge.),具有抗氧化特性。
E3364 Physalis alkekengi Extract
E3366 Fineleaf schizonepeta herb Extract
E3367 Garlic chives Extract Garlic chives Extract从韭菜Allium tuberosum中提取,为NLRP3炎性体驱动疾病的治疗提供了一种新的治疗方法。
E3368 Chinese Chive seed Extract
E3369 Radix Platycodonis Extract Radix Platycodonis Extract是从桔梗(Platycodon grandiflorus)中提取的,具有多种药理活性。
E3371 Chrysanthemi Extract Chrysanthemi Extract从菊花Flos Chrysanthemi中提取,常用于治疗感冒、流感、头痛、视力模糊、眼红、头晕、皮肤溃疡等。
E3372 Chicory Extract Chicory Extract是从菊苣Cichorium intybus中提取的,可以作为天然着色剂或食品中的抗氧化剂。
E3374 Exocarpium Citri Rubrum Extract
E3376 Saw palmetto Extract
E3377 Symphytum officinale Extract Symphytum officinale Extract从聚合草Symphytum officinale中提取,在民间医学中常用于促进伤口愈合、消炎和治疗骨折。
E3378 Selaginella Extract Selaginella Extract从卷柏Selaginella中提取,具有相当的生物学特性,可用于新兴护理中的疼痛管理。
E3379 Cassia seed Extract Cassia seed Extract是从决明(Cassia toraLinn)的种子中提取的,具有影响多种生物学过程和途径的潜力,包括对平滑肌细胞增殖、炎症反应、肿瘤坏死因子(TNF)信号通路的正调控 、血管内皮生长因子(VEGF)信号通路和花生四烯酸(ARA)代谢。
E3380 Coffee fruit Extract
E3382 Camu Camu fruit Extract Camu Camu fruit Extract是从桃金娘科卡姆果Myrciaria dubia McVaugh的果实中提取的,有助于预防氧化应激和由高糖水平引起的皮肤炎症。
E3385 Cocoa Extract
E3386 Wormwood Extract
E3388 Latifolin Extract Ilex kudingcha C.J. Tseng Extract从苦丁茶Ilex kudingcha C.J. Tseng中提取,具有广泛的药理特性,包括抗氧化、保肝、抗菌、抗组胺、抗癌、神经保护等生物作用。
E3389 Sophora alopecuroides seed Extract
E3391 Balsam Pear Powder Balsam Pear Powder提取自苦瓜Momordica charantia,传统上被认为对健康有益,主要是对糖尿病有治疗作用。
E3393 Fructus azedarach Extract Fructus azedarach Extract是从苦楝皮(Fructus azedarach)中提取的。
E3394 Quassia Extract
E3395 Tartary buckwheat Extract Tartary buckwheat Extract从苦荞Tartary buckwheat中提取,具有抗氧化、低胆固醇血症、抗炎症等生物活性作用。
E3396 Bitter almond Extract Bitter almond Extract是从苦杏仁( Semen Armeniacae Amarum.)中提取的。
E3397 Coltsfoot Extract
E3398 Sunflower dish Extract Sunflower dish Extract是从向日葵中提取的,具有抗氧化、抗菌、抗增殖和DNA保护作用。
E3399 Kelp Extract
E3400 Chili pepper Extract
E3401 Polygonum hydropiper Extract Polygonum hydropiper Extract从辣廖Polygonum hydropiper中提取,通过抗氧化和抗炎途径对胃损伤有保护作用。
E3402 Moringa oleifera leaf Extract Moringa oleifera是从辣木Moringa oleifera的叶子中提取的,含有抗氧化剂、抗生素和营养物质,包括维生素和矿物质。
E3403 Moringa pterygosperma seed Extract Moringa pterygosperma seed Extract是从传统药用的尤辣木Moringa pterygosperma种子中提取而成。
E3404 Raphanus sativus seed Extract
E3405 Cymbidium ensifolium Extract Cymbidium ensifolium Extract从兰草Cymbidium ensifolium中提取,对多种癌细胞有很好的抗癌作用。
E3407 Blueberry Extract Blueberry Extract是从蓝莓Vaccinium Section Cyanococcus中提取的,具有抗氧化、抗炎和神经保护的特性。
E3408 Radix Euphorbiae Ebracteolatae Extract Radix Euphorbiae Ebracteolatae Extract是从狼毒(Radix Euphorbiae Ebracteolatae)中提取的,它通过抑制肾脏中的PKC活性来调节水通道蛋白。
E3409 Geranium wilfordii Extract Geranium wilfordii Extract是从老颧草(Geranium wilfordii)中提取的,具有抗病毒活性。
E3406 Blue indigo Extract Blue indigo Extract从蓝靛果Lonicera caerulea中提取,用于治疗细菌感染、胃肠道疾病和代谢性疾病。
E3410 Tripterygium wilfordii Extract Tripterygium wilfordii Extract提取自雷公藤(Tripterygium wilfordii),其有效成分可通过抑制PI3K/AKT/mTOR信号通路诱导自噬。
E3411 Veratrum nigrum L. Extract Veratrum nigrum L. Extract是从藜芦(Veratrum nigrum L.)中提取的,具有抗炎、抗氧化、抗癌等药理作用。
E3412 Quinoa Extract Quinoa Extract是从藜麦Chenopodium quinoa Willd.中提取的,用于预防和治疗肥胖和肥胖相关疾病。
E3413 Plum Extract Plum Extract提取自李子Prunus domestica,由于其能够促进肌肉生成,刺激肌肉蛋白质合成,抑制蛋白质降解,对肌肉有健康益处。
E3414 Semen litchi Extract Semen litchi Extract是从荔枝Litchi chinensis中提取的,具有抗肝癌作用,并通过靶向VEGFR抑制肝细胞癌血管生成。
E3415 Forsythia suspensa Extract Forsythia suspensa Extract是从连翘(Forsythia suspensa)中提取的。
E3416 Lotus seed Extract Lotus seed Extract是从荷花Nelumbo nucifera种子中提取的,具有抗氧化、抗炎、抗癌等多种功效。
E3417 Nitidum Extract Nitidum Extract是从两面针Zanthoxylum Nitidum中提取的,以抗炎镇痛作用而闻名。
E3418 Rhizoma Anemones Raddeanae Extract Rhizoma Anemones Raddeanae Extract从两头尖Anemone raddeana Regel的根茎中提取,用于治疗风寒症状、手足病痉挛、关节痛、溃疡痛。
E3419 Ganoderma lucidum Extract Ganoderma lucidum Extract从灵芝(Ganoderma lucidum)中提取,可调节Nrf2和Nrf2相关蛋白。
E3420 Trumpet creeper Extract Trumpet creeper Extract是从凌霄花Campsis中提取的,具有抗菌和抗真菌的特性。
E3421 Diverse wormwood herb Extract Diverse wormwood herb Extract提取自中药刘寄奴(Herba Artemisiae Anomalae).
E3422 Spearmint Extract Spearmint Extract是从留兰香Mentha spicata中提取的,这可能是一种对认知健康有益的营养干预。
E3423 Gentian Extract Gentian Extract是从龙胆草(Adenophora capillaris)中提取的。
E3424 Solanum nigrum Extract Solanum nigrum Extract从龙葵(Solanum nigrum Linn.)中提取,在体内和体外均具有抗肿瘤、抗炎、抗氧化、抗菌和神经保护作用。
E3425 Dragon's blood Extract
E3426 Piper betle L. Extract
E3427 Uniflower swisscentaury root Extract Uniflower swisscentaury root Extract提取自漏芦(Rhaponticum uniflorum (L.) DC.)的根,可通过Nrf2/HO-1信号通路缓解炎症反应。
E3428 Reed rhizome Extract Reed rhizome Extract是从中药芦根,即芦苇(Phragmites australis)的根中提取的。
E3429 Aloe vera Extract Aloe vera Extract提取自芦荟Aloe vera,传统上被用于治疗皮肤损伤和消化问题,因为它具有抗炎、抗菌和伤口愈合的特性。
E3431 Asparagus Extract Asparagus Extract从芦笋Asparagus officinalis中提取,含有适应性、神经保护、抗氧化、抗炎和益智活性。
E3432 Calamine Extract
E3434 Deer antler velvet Extract
E3435 Pyrola herb Extract
E3436 Liquidambar formosana Extract
E3437 Apocynum venetum Extract
E3438 Momordica grosvenori Extract
E3439 Basil Extract
E3440 Tamarindus indica seed Extract
E3441 Radish root Extract
E3442 Radish leaves Extract
E3359 Honeysuckle flower Extract Honeysuckle flower Extract是从中药金银花(Lonicera japonica Thunb)中提取的,具有抗菌、抗病毒、抗炎的特性。
E3811 Cashew Extract
E3812 Rhamnus Cathartica Extract
E3813 Chrysanthemum Indicum Extract
E3814 Phyllanthus Urinaria Extract
E3815 Caulis Polygoni Multiflori Extract
E3816 Emilia Sonchifolia Extract
E3817 Eucalyptus Globulus Fruit Extract
E3818 Solidago Decurrens Extract
E3820 Leonurus Japonicus Extract
E3821 Alpinia Oxyphyllae Extract
E3824 Scepteridium Ternatum Extract
E3825 Herba Artemisiae Capillaris Extract
E3826 Tremella Extract
E3827 Ginkgo Biloba Extract 银杏叶提取物是从银杏树Ginkgo biloba L.的叶子中提取的。银杏叶提取物应用于多种疾病,包括抑郁情绪、多发梗塞性痴呆、脑功能不全(以记忆障碍、注意力不集中、焦虑和困惑等症状为特征)、心肌缺血、中风、血栓形成和外周闭塞性动脉病(POAD)。
E3829 Epimedium Brevicornu Extract
E3830 Prunus Serrulata Extract
E3831 Cherry Powder Extract (Pink) Extract
E3832 Cherry Extract
E3833 Cherry Extract (Brown) Extract
E3834 Jasminum Nudiflorum Extract
E3835 Cordyceps Militaris Extract
E3836 Cole Flowers Extract
E3838 Phyllanthus Emblica Extract
E3839 Houttuynia Cordata Extract
E3840 Ulmus Pumila Bark Extract
E3841 Kale Extract
E3842 Corn Extract
E3843 Corn Stigma Extract
E3844 Polygonatum Odoratum Extract
E3845 Radix Curcumae Root Extract
E3846 Semen Pruni Extract
E3848 Hypericum Sampsonii Extract
E3849 Scrophularia Ningpoensis Extract
E3850 Rhizoma Corydalis Extract
E3851 Radix Polygalae Extract
E3852 Oenothera Biennis Extract
E3853 Blueberry Fruit Extract
E3854 Coriolus Versicolor Extract
E3857 Gieditsia Sinensis Lam Fruit Extract
E3858 Quillaia Extract
E3859 Lycopus Extract
E3860 Euphorbia Helioscopia Extract
E3861 Rhizoma Alismatis Extract
E3862 Japanese Xylosma Twig Extract
E3863 Swertia Bimaculata Extract
E3864 Cockroach Extract
E3865 Catharanthus Roseus Extract
E3867 Fritillariae Thunbergii Bulbus Extract
E3868 Pearl Extract
E3869 Anemarrhena Extract
E3870 Gardenia Fruit Extract Gardenia fruit Extract是从茜草科的开花植物栀子(Gardenia jasminoides Ellis.)果实中提取的。栀子不仅用作食用色素,还用作治疗肝病、头痛、黄疸、炎症和高血压的药物。
E3871 Valeriana Root Extract
E3872 Hovenia Dulcis Fruit Extract
E3873 Hovenia Dulcis Seed Extract
E3874 Hovenia Dulcis Extract
E3875 Unripe Bitter Orange Extract
E3877 Processed Cyperus Extract
E3878 Stalactitum Extract
E3879 Glabrous Sarcandra Herb Extract
E3880 Rhizoma Paridis Extract
E3881 Swine'S Gallbladder Extract
E3882 Swine'S Liver Extract 猪肝提取物是从猪肝中提取的。猪肝是一种有价值的食用屠宰副产品,适合人类食用。
E3883 Umbellate Pore Fungus Extract
E3884 Galium Aparine Extract
E3885 Swine‘S Pancreas Extract
E3886 Bamboo Sap Extract
E3887 Bamboo Shaving Extract
E3888 Cortex Illicii Extract
E3889 Cumin Extract
E3890 Lithospermum Erythrorhizon Extract
E3891 Red Cabbages Extract
E3892 Viola Philphica Munda Extract
E3893 Medicago sativa Extract
E3894 Ardisia Japonica Extract
E3895 Perilla Frutescens Extract
E3896 Perilla Leaf Extract
E3897 Purple Perilla Seed Extract
E3898 Radix Asteris Extract
E3899 Echinacea Extract (flower) Purple coneflower Extract来源于紫锥花,即紫锥菊( Echinacea purpurea, Echinacea angustifoliaEchinacea pallida)的花朵。紫锥花用于治疗呼吸道感染和炎症,包括普通感冒、咳嗽、支气管炎和口咽炎症。
E3900 Echinacea Extract
E3901 Ribes Henryi Root Extract
E3801 Morchella Extract
E3802 Inula Cappa Extract
E3803 Goat Liver Powder Extract
E3804 Aspen Flower Extract
E3805 Psyllium Husk Extract
E3806 Allium Cepa Extract
E3807 Chamomile Extract
E3810 Bauhinia Variegata Extract
E3700 Descurainiae Semen Lepidii Semen Extract
E3701 Phryma Leptostachya L. var. asiatica Hara Extract
E3702 Eupolyphage sinensis Walker Extract
E3703 Talinum paniculatum Extract
E3704 Rumex madaio Makino Extract
E3705 Smilax glabra Extract
E3706 Cortex pseudolaricis Extract
E3707 Chenopodium ambrosioides Extract
E3708 Cephaelis ipecacuanha Extract
E3709 Lagotis glauca Extract
E3710 Chinese Dodder Seed Extract
E3712 Pisum sativum Extract
E3713 Vaccariae semen Extract
E3714 Clematis chinensis Extract
E3715 Crinum Asiaticum Extract
E3716 Equisetum arvense Extract
E3717 Lactuca sativa Extract
E3718 Marsdeniae Tenocissimae Extract
E3719 Seed of Chinese Tallowtree Extract
E3720 Oolong tea Extract
E3721 Fructus mume Extract
E3722 Zaocys dhumnades Extract
E3723 Lindera aggregata leaves Extract
E3724 Ficus carica Extract
E3737 Passiflora caerulea Linnaeus Extract
E3738 Lycopersicon esculentum Miller Extract
E3739 Panax quinquefolium Extract
E3740 Isodon serra Extract
E3741 Herba Siegesbeckiae Extract
E3742 SHILAJIT Asphaltum Extract
E3744 Prunella Vulgaris Extract
E3746 hsian-tsao Extract
E3747 Agrimonia pilosa Extract
E3748 Epimedium Extract
E3749 Curculigo orchioides Extract
E3750 Opuntia dillenii Extract
E3753 Coriander Extract
E3754 Coriander Roots Extract
E3755 Cyperus Rotundus Extract
E3756 Vetiveria Zizanioides Extract
E3757 Shiitake Mushroom Extract
E3760 Cymbopogon Citratus Extract
E3761 Elsholtzia Ciliata Extract
E3762 Amomum Extract
E3763 Sweet Potatoes Extract
E3765 Citrus Medica Extract
E3766 Feverfew Extract
E3767 Justicia Gendarussa Extract
E3768 Foeniculum Vulgare Extract
E3769 Cirsium Setosum Extract
E3770 Wheat Germ Extract
E3771 Millet Extracts Extract
E3772 Eyebright Extract
E3774 Chlorella Pyrenoidosa Extract
E3775 Valeriana Officinalis Extract
E3776 Allium Macrostemnon Extract
E3780 Pleurotus eryngii Extract
E3781 Bombyx Moril Extract
E3782 Arctostaphylos Uva Ursi Leaf Extract
E3783 Spiraea Salicifolia Extract
E3784 Cynanchum Paniculatum Extract
E3785 Radix Dipsaci Extract
E3786 Radix Scrophulariae Extract
E3787 Flos Inulae Extract
E3788 Smallanthus Sonchifolius Extract
E3789 Saussurea Involucrata Extract
E3790 Sambucus Adnata Extract
E3791 Surgentodoxa Cuneata Extract
E3792 Lavandula Angustifolia Extract
E3793 Urtica Fissa Extract
E3794 Brucea Javanica Extract
E3796 Flaxseed Extract
E3795 Commelina Communis Extract
E3797 Butea Superba Extract
E3798 Avena Sativa L. Extract
E3799 Arrhenatherum Elatius Extract Arrhenatherum elatius Extract提取于植物燕麦草Arrhenatherum elatius (L.) Pressl.。燕麦草具有去除土壤中重金属的能力。
E3800 Nidus Collocaliae Extract
E3576 Semen celosiae Extract
E3577 Okra Extract
E3579 Undaria pinnatifida Extract
E3582 Ginseng leaf Extract
E3583 Honeysuckle flower Extract
E3584 Lonicera japonica vine Extract
E3585 Desertliving cistanche herb Extract
E3586 Myristica fragrans Extract
E3587 Cinnamon Extract
E3588 Boswellia Extract
E3589 Evodia Lepta Bark Extract
E3591 Common burreed tuber Extract Common burreed tuber Extract是从中药三棱(Sparganium stoloni erum,Buch. -Ham.) 中提取的,具有抗氧化特性。
E3592 Panax notoginseng Root Extract
E3590 Radix berberidis Extract
E3593 Panax notoginseng Rhizoma Extract
E3594 Radix tetrastigme Extract
E3595 White mulberry root-bark Extract
E3596 Phellinus linteus Extract
E3597 Herba taxilli Extract
E3598 Morus alba bark Extract
E3599 Mantis egg-case Extract
E3600 Mulberry Extract
E3601 Mulberry Extract (leaves) Mulberry Extract (leaves)来源于传统中草药桑叶 Morus alba L.。桑叶具有抗氧化、抗炎、抗糖尿病和抗肿瘤等多种生物学功能。
E3658 Double coptis chinensis Extract
E3689 Radix Asparagi Extract Radix Asparagi Extract提取于百合科植物天冬Asparagus cochinchinensis (Lour.) Merr.的干燥块根。因其高抗氧化活性而对炎症疾病有效。天冬提取物可以抑制蘑菇的褐变反应,类似于抗坏血酸。
E3690 Semiaquilegiae Radix Extract
E3691 Gastrodia Rhizome Extract
E3692 lucid asparagus Extract
E3694 Geranium Extract
E3695 Hypericum japonicum Extract
E3696 Panax notoginseng Extract
E3578 Fringed pink Extract
E3139 Angelica Sinensis Extract Angelica Sinensis Extract提取自当归Angelica Sinensis (Radix Angelica Sinensis)的干燥根部,其对脑梗死的作用是通过多种途径实现的,包括抗关节硬化、改善微循环、抗血小板聚集、抗炎、抗氧化等作用。
E3169 Angelicae Pubescentis Radix Extract Angelicae Pubescentis Radix Extract是从独活Angelica biserrata的干燥根中提取的,是一种列入《中国药典》的抗风湿镇痛剂,常治疗风湿性关节炎和头痛。
E3171 Lamiophlomis Herba Extract Lamiophlomis Herba Extract是藏药独一味Lamiophlomis Rotata的水提物,具有止血作用。
E3172 Juniper Berry Extract Juniper Berry Extract是从杜松子(Juniperus communis L.)中提取的,可作为化学预防膳食剂,抑制细胞增殖和诱导细胞凋亡,从而减少结肠肿瘤的形成。
E3173 Eucommiae Cortex Extract 杜仲提取物是从原产于中国的稀有滋补药材杜仲(Eucommiae Cortex)树皮中提取的,对治疗高血压有很好的疗效。
E3175 Eucommia Ulmoides Male Flower Extract
E3176 Curcumae Rhizoma Extract Curcumae Rhizoma Extract 提取自中药莪术(Curcumae Rhizoma)。
E3177 Centipeda Minima Extract Centipeda Minima Extract是从药材鹅不食草(Centipeda Minima)中提取的,具有良好的抗癌活性。
E3178 Catechu Extract Catechu Extract是从儿茶(Areca catechu L.)中提取的,具有治疗多种疾病的潜力,尤其是寄生虫病、消化功能障碍和抑郁症。
E3181 Anona Squamosa Leaf Extract
E3182 Carica Papaya Fruit Extract Carica Papaya Fruit Extract从番木瓜(Carica Papaya)的果实中提取,已被证明具有抗蠕虫和抗阿米巴的活性。
E3183 Carica Papaya Leaf Extract
E3184 Solanum Lycopersicum Extract Solanum Lycopersicum Extract 从番茄(Solanum Lycopersicum)中提取,可用于治疗心血管疾病、神经系统疾病,并可作为抗氧化剂、抗癌剂和抗菌剂。
E3185 Psidium Guajava Extract
E3186 Sennae Folium Extract Sennae Folium Extract 提取自中药番泻叶(Sennae Folium)。
E3187 Descolor Cinquefoil Herb Extract
E3188 Cissus Quadrangularis Extract
E3189 Saposhnikoviae Radix Extract Saposhnikoviae Radix Extract 提取自中药防风(Saposhnikoviae Radix)。
E3190 Stephaniae Tetrandrae Radix Extract
E3191 Euphorbia Hirta Extract
E3193 Saponaria Officinalis Extract
E3194 Torreyae Semen Extract Torreyae Semen Extract是从香榧(Torreya grandis)的种子中提取的,可用于治疗肠道寄生虫。
E3195 Combretum alfredii Hance Extract Combretum alfredii Hance Extract是从风车子(Combretum alfredii Hance)中提取的。
E3198 Kadsura longipedunculata Ratan Extract
E3227 Uncaria Extract
E3228 Cynodon Dactylon Extract
E3229 Lycii Fructus Extract
E3230 Eriocauli Flos Extract
E3231 Setariae Fructus Germinatus Extract
E3232 Rhizoma Drynariae Extract Rhizoma Drynariae Extract提取自中药骨碎补(Rhizoma Drynariae)。
E3233 Trichosanthis Fructus Extract
E3234 Trichosanthis Pericarpium Extract Trichosanthis Pericarpium Extract从瓜蒌皮Trichosanthis Pericarpium中提取,能够通过调节PI3K/Akt/NO通路保护心肌细胞免受缺氧/复氧损伤。
E3235 Hypericum Perforatum Extract Hypericum Perforatum Extract是从贯叶连翘(Hypericum Perforatum)中提取的,具有抗血小板特性。
E3236 Champion Wood Fern Extract
E3237 Euonymus alatus Sieb Extract Euonymus alatus Sieb Extract从鬼箭羽Euonymus alatus Sieb中提取,可协同低密度胰岛素提高脂肪细胞的葡萄糖摄取率。
E3238 Bidens Bipinnata Extract Bidens Bipinnata Extract从鬼针草Bidens Bipinnata L中提取,在传统医学中用于治疗各种炎症。
E3239 Osmanthus Extract Osmanthus Extract从桂花(Osmanthus fragrans)中提取,具有神经保护、自由基清除和抗氧化作用,也是天然抗衰老化合物的良好来源。
E3240 Longan Extract Longan Extract是从龙眼(Dimocarpus longan)中提取的,龙眼具有抗氧化、抗增殖、降血糖和降尿酸的作用。
E3241 Cinnamomi Ramulus Extract 桂枝提取物是从桂枝(Cinnamomi Ramulus)中提取的,可通过Akt/ERK信号通路抑制结肠癌细胞的生长。
E3242 Gecko Extract Gecko Extract是从蛤蚧(Gekko gecko)中提取的。
E3243 Pinus Pinaster Bark Extract
E3244 Laminaria Japonica Extract
E3245 Piperis Kadsurae Caulis Extract Piperis Kadsurae Caulis Extract提取自海风藤,能够降低细胞中 IL-1β 和 TNF-α 的表达水平。
E3246 Lygodii Spora Extract
E3247 Hainan Nightshade Fruit Extract
E3248 Oriental Variegated Coralbean Bark Extract Oriental Variegated Coralbean Bark Extract提取自海桐皮(Aralia chinensis L.),可预防心肌缺血/再灌注损伤,减少钙稳态失衡和ERS相关的细胞凋亡。
E3299 Polygonum Cuspidatum Extract Polygonum Cuspidatum Extract是从虎杖(Reynoutria japonica Houtt)中提取的。
E3300 Pericarpium Zanthoxyli peel Extract 花椒果皮提取物中得到证实的有效成分主要为挥发油、生物碱、酰胺,其他成分有香豆素、木质素、脂肪酸、黄酮类等,此外还有少量的氨基酸和矿物质。
E3301 Peanut hull Extract 花生壳提取物中含有丰富的黄酮类色素,以贰元形式存在较多,可用于开发天然黄色素。
E3302 Peanut seed coat Extract 花生衣水提物中含有丰富的生物活性成分,具有防治化疗诱导的血小板减少的生理作用。
E3303 Achyranthes bidentata Blume root Extract Achyranthes bidentata Blume root Extract源自牛膝根 Achyranthes bidentata的干燥根部,对高脂饲料喂养大鼠具有抑制脂肪生成和控制体重的作用。
E3304 Sophora japonica fruit Extract Sophora japonica fruits Extract (Fructus Sophorae Extract, Rexflavone)源自槐树Sophora japonica的果实,含有丰富的异黄酮类成分,也是一种具有显著改善绝经指数的保健功能性食品成分。
E3305 Sophora flower Extract Sophora flower Extract源自槐树Sophora japonica的干花,在中国、日本和韩国用于治疗呕血和痔疮出血。
E3306 Phellodendron amurense bark Extract Phellodendron amurense bark Extract (Nexrutine)源自黄柏Phellodendron amurense的树皮,在体内外均显示出良好的前列腺癌治疗作用。
E3308 Daylily flower Extract Daylily flower Extract源自黄花菜Hemerocallis citrina的花朵和花蕾部位,具有神经保护作用。
E3309 Polygala fallax Hemsl. rhizome Extract 黄花倒水莲的药用价值主要在根部.其根含有皂苷类、糖脂类、酮类、有机酸类等物质。能对免疫功能产生影响,具有抗应激、抗炎、活血、调脂、对乙肝病毒体外抑制等作用。
E3310 Brassica juncea seed Extract Brassica juncea seeds Extract源自黄芥子Brassica juncea的种子,含有丰富的酚类成分。
E3311 Rhizoma polygonati root Extract Rhizoma polygonati Extract源自黄精Rhizoma polygonati的根部,历史悠久,含有多种化学成分,具有抗癌、抗衰老、抗糖尿病、抗疲劳、预防疾病等作用,或作为食品中的营养来源。
E3312 Rhizoma Coptidis Root Extract Rhizoma coptidis Extract源自毛茛科药用植物黄连Rhizoma coptidis的干燥根部,已被中医使用了2000多年。
E3313 Rhizoma Coptidis Fibrous Root Extract Rhizoma Coptidis Fibrous Root Extract是从黄连(Rhizoma Coptidis)须根中提取的。
E3315 Astragalus rhizome Extract Astragalus Root Extract源自黄芪Radix Astragali的根部,主要成分为多糖、黄酮类化合物、皂苷、氨基酸和微量元素,具有抗炎、免疫调节、抗氧化、抗癌等作用。
E3316 Scutellariae rhizome Extract Scutellariae rhizome Extract源自黄芩Scutellaria baicalensis的根茎,以黄芩苷为主要成分,长期以来在中国、日本、韩国作为传统药物和功能食品,用于治疗炎症、发热、肝炎、过敏性疾病、高血压等疾病。
E3317 Okra fruit Extract Scutellariae rhizome Extract源自黄芩Scutellaria baicalensis的根茎,以黄芩苷为主要成分,长期以来在中国、日本、韩国作为传统药物和功能食品,用于治疗炎症、发热、肝炎、过敏性疾病、高血压等疾病。
E3318 Cistus Incanus Extract Cistus incanus Extract源自地中海灌木植物Cistus incanus L.,含有丰富的多酚类化合物,具有显著的抗氧化活性,可能是化妆品工业的有效活性成分。
E3322 Agastache rugosa Extract Agastache rugosa Extract是从藿香(Agastache rugosa )中提取的。
E3323 Plumeria rubra Extract
E3324 Herba abri Extract
E3325 Croton crassifolius Geisel. Extract
E3326 Gizzard pepsin Extract Gizzard pepsin Extract是从家鸡( Gallusgallusdomesticus Brisson)的干燥沙囊中提取的。
E3327 Chinese fevervine herb Extract
E3328 Suberect spatholobus stem Extract Suberect spatholobus stem Extract 从中药鸡血藤(Suberect spatholobus)中提取,可抑制TGF-β1/p38MAPK信号通路和ColⅠ的合成,从而起到治疗肝纤维化的作用。
E3329 Centella asiatica Extract
E3330 Agaricus blazei Extract Agaricus blazei Extract从姬松茸Agaricus blazei Murill中提取,被认为具有抗肿瘤和抗氧化活性。
E3331 Impatiens balsamina L. Extract
E3333 Viburnum dilatatum Extract
E3334 Bacopa monniera Extract Bacopa monniera Extract是从假马齿苋Bacopa monniera中提取的,几个世纪以来,一直被用作传统的阿茹吠陀药物,用于治疗记忆和炎症。
E3335 Curcuma longa Extract Curcuma longa Extract是从姜黄(Curcuma longa)中提取的。
E3337 Larva of a Silkworm with Batrytis Extract
E3338 Lignum Dalbergiae odoriferae Extract
E3339 Malt Extract
E3341 Hawthorn Extract
E3342 Carob bean Extract
E3343 Gynostemma pentaphyllum Extract Gynostemma pentaphyllum Extract源自绞股蓝Gynostemma pentaphyllum全草,通过上调C2C12骨骼肌中PGC-1α,促进肌管分化和线粒体代谢,提高运动性能。
E3344 Yeast extract
E3345 ElderBerry Extract ElderBerry Extract是从接骨木Sambucus 的浆果中提取的,传统上被用于预防和治疗呼吸问题。
E3346 Oriental Paperbush flower Extract Oriental Paperbush flower Extract是从结香Edgeworthia chrysantha的花中提取的,可能是治疗骨质疏松等骨质溶解性疾病的潜在药物。
E3347 Mustard Extract
E3348 Capsella bursa-pastoris Extract
E3349 Broccoli Extract Broccoli Extract是从芥兰Brassica oleracea var. italica中提取的,具有抗诱变的特性。
E3350 Goodyera kwangtungensis Tso. extract Goodyera kwangtungensis Tso. Extract取自金边莲Goodyera kwangtungensis C.L. Tso,整株植物用于改善肺部状况和清痰。
E3351 Abrus mollis Extract Abrus mollis Extract从鸡骨草Abrus mollis中提取,是一种民间饮料和汤,有净化肝脏毒素、预防肝脏疾病的作用。
E3352 Radix Tinosporae Extract Radix Tinosporae Extract从金果榄Radix Tinosporae中提取,是一种治疗各种炎症性疾病的中药。
E3353 Acacia farnesiana Extract
E3574 Cyclocarya paliurus Extract
E3307 Soybean Extract Soybean Extract源自黄豆的果实,可以调节视黄酸相关基因,并显示出光保护作用,这表明其可能是一种可以在阳光下安全使用的抗衰老成分。
E2762 Azadirachtin B

Azadirachtin B, a limonoid isolated from seed kernels of <i>Azadirachta indica</i>, has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties.

E3122 Arecae Pericarpium Extract
E3124 Cirsii Japonici Herba Extract
E3125 Hordeum Vulgare Extract Hordeum Vulgare Extract是从大麦(Hordeum vulgare)中提取的,其减少脂质的吸收是抗肥胖作用的基础。
E3126 Rice Extract Rice Extract是从大米(Oryza sativa)中提取的,具有预防绝经后妇女脂肪肝的功效。
E3128 Isatidis Folium Extract Isatidis Folium Extract从大青叶Isatis indigotica Fort. (十字花科)的干叶子中提取,作为解热、抗病毒、消炎、抗流感和抗癌剂,在东方国家已普遍应用了几个世纪。
E3130 Garlic Extract Garlic Extract是从大蒜(Allium sativum)中提取的,具有抗高血压、抗高血脂、降血糖的作用。
E3131 Jujubae Fructus Extract Jujubae Fructus Extract是从大枣Ziziphus jujuba Mill的果实中提取的,对慢性便秘和2型糖尿病有有效的治疗作用。
E3132 Citrus Aurantium Flower Extract Citrus Aurantium Flower Extract是从代代花(Citrus Aurantium)中提取的,主要用于治疗消化问题。
E3134 Sphaeranthus Africanus Extract Sphaeranthus Africanus Extract从戴星草Sphaeranthus africanus中提取,其中Carvotacetone类化合物具有抗分支杆菌作用。
E3135 Salvia Miltiorrhiza Extract Salvia Miltiorrhiza Extract从丹参Salvia miltiorrhiza (唇叶科)中提取,含有丰富的丹参酮I、丹参酮II、丹参新酮和丹酚酸等多种化合物,其中尤以丹参根为甚,具有抗氧化、抗微生物、抗病毒、抗癌、抗炎、心血管疾病等药理活性。
E3137 Fermented Soybean Extract Fermented Soybean Extract是从发酵大豆中提取的,具有较高的抗氧化活性。
E3138 Lophatheri Herba Extract Lophatheri Herba Extract提取自淡竹叶Herba Lophatheri,可增强壳聚糖膜的耐水耐油性,壳聚糖膜的抑菌活性随时间的推移而下降。
E3141 Codonopsis Pilosula Extract Codonopsis Pilosula Extract提取自党参Codonopsis pilosula,不仅对正常黑素细胞有抗黑素作用,而且通过诱导自噬和小眼相关转录因子(MITF)表达,对氧化应激的黑素细胞有细胞保护作用。
E3142 Semen Canavaliae Extract Semen Canavaliae Extract是从刀豆(Canavalia Gladiate)中提取的,它是一种天然的抗氧化剂和抗菌剂,具有潜在的健康益处以及在食品工业中的应用。
E3143 Ground Ginseng Extract Ground Ginseng Extract提取自唇形科地笋属植物硬毛地参(Lycopus lucidus var. hirtus Regel)的干燥根茎。
E3145 Kochiae Fructus Extract Kochiae Fructus Extract从地肤子Kochia scoparia (L.) Schrad.中提取,由于具有抗炎、抗糖尿病、杀虫、抗过敏、止痒、抗类风湿性关节炎等药理活性而受到广泛关注。
E3146 Sweet Potato Root Extract Sweet Potato Root Extract是从地瓜根(Ipomoea batatas)中提取的,它是一种极好的新型天然促健康物质的来源,例如β-胡萝卜素和花青素。
E3148 Euphorbiae Humifusae Herba Extract
E3149 Pheretima Extract
E3150 Dinian Herb Extract
E3151 Sanguisorbae Radix Extract
E3152 Junci Medulla Extract Junci Medulla Extract从灯芯草Junci Medulla中提取,促进排尿,滤除湿气,解除疼痛的尿功能障碍,冷却血液,止血。
E3153 Corchorus Olitorius Extract Corchorus olitorius Extract是从帝王菜(Corchorus Olitorius)的叶子中提取的,具有抗炎、抗氧化、抗癌和保肝作用。
E3156 Clitoria Ternatea Flower Extract
E3157 Erycibes Caulis Extract
E3158 Caryophylli Flos Flower Extract
E3159 Caryophylli Flos Extract Caryophylli Flos Extract提取自丁香Caryophylli Flos,对野生型SARS-CoV和HIV/SARS-CoV S伪病毒感染有抑制作用,在病毒分别为30.3±2.6 μg/mL和58.8±5.6 μg/mL,抑制效果中等(IC50<100 μg/mL),。
E3162 Wax Gourd Peel Extract Wax Gourd Peel Extract是从冬瓜(Benincasa hispida)的果皮中提取的,用于防治高脂血症、高血糖症、肥胖症、心血管疾病等代谢性疾病。
E3163 Wax Gourd Seed Extract Wax Gourd Seed Extract是从冬瓜(Benincasa hispida)的果实中提取的,具有抗炎、心血管、保肝作用,对乳腺癌细胞具有细胞毒性。
E3164 Malvae Fructus Extract
E3165 Rabdosiae Rubescentis Herba Extract Rabdosiae Rubescentis Herba Extract提取自唇形科冬凌草Rabdosia rubescens (Hemsl.) Hara的地上干燥部分,具有抗菌、抗寄生虫、抗炎、抗癌等多种生物活性。
E3168 Bean Sprout Extract
E3034 Cynanchi Atrati Extract Cynanchi Atrati Extract是从白薇Cynanchi atrati Radix中提取的,传统上用作抗炎剂,具有抑制IKK介导的NF-κB激活的潜力,具有调节炎症或癌症条件的价值。
E3035 Dittany Bark Extract Dittany Bark Extract从白藓Dittany的皮中提取,常用于治疗炎症、细菌和真菌感染,减轻炎症和消化健康。
E3037 Solanum lyratum Extract Solanum lyratum Extract (300 μg/ml)可以增加Bax水平,降低Bcl-2的水平,导致线粒体膜电位(Δæm)丢失,细胞色素C释放,caspase-9和-3激活,最终导致细胞凋亡。Solanum lyratum Extract (300 μg/ml)还促进p53和p27分泌,但降低cyclin B1水平,从而导致S期阻滞。
E3038 White Kidney Bean Extract White kidney bean extract是从白芸豆Phaseolus vulgaris L.中提取的,对体重和代谢健康有有益作用。
E3039 Angelica Root Extract
E3040 Stemonae Extract Stemonae Extract从百部Radix Stemonae的根茎中提取,作为一种口服镇咳药,在中医中已有几千年的历史,具有镇咳、抗结核、抗菌、抗真菌、抗寄生虫等药理作用。
E3042 Lily Bulbs Extract
E3043 Thymus Serpillum Extract Thymus Serpillum Extract是从百里香Thymus serpyllum中提取的,是一种芳香类药用植物,具有多种生物学特性,包括抗癌活性。
E3044 Passion Fruit Extract
E3045 Chinese Arborvilea Seed Extract Chinese Arborvilea Seed Extract提取自侧柏Platycladus orientalis (L.)Franco的干燥成熟种仁,具有明显的抗焦虑作用,其作用机制可能与增加海马组织γ-氨基丁酸(GABA)的水平和降低谷氨酸(Glu)的水平有关。
E3047 Isatis Extract Isatis Extract提取自板蓝根Baphicacanthus cusia,可能能够抵抗引起感染的细菌和病毒,降低发烧和肿胀,也可能阻止癌细胞繁殖。
E3048 Chestnut Extract Chestnut Extract从板栗Castanea Sativa中提取,可用于治疗慢性静脉功能不全(CVI)。
E3049 Lobeliae Chinensis Extract
E3051 Scutellaria Barbata Extract Scutellaria Barbata Extract提取自半枝莲Scutellaria barbataScutellaria barbata纳米粒子(Sb-AgNP)能有效抑制生物膜的形成,对皮肤感染引起的微生物具有抗菌作用。
E3046 Patriniae Extract Patriniae Extract提取自败酱草Herba patriniae,能够显著减少Pseudomonas aeruginosa的生物膜形成,并显著改变成熟生物膜的结构。
E3052 Cabbage Extract Cabbage extract是从包心菜Brassica oleracea var. capitata中提取的,对葡萄糖稳态有多靶点调节作用,有助于预防和治疗2型糖尿病。
E3053 Mentha Arvensis Leaf Extract
E3054 Primula Malacoides Extract
E3055 Rhizoma Menispermi Extract Rhizoma Menispermi Extract是从北豆根Menispermum dauricum DC中提取的,具有显著的抗癌、抗缺氧等生物活性。
E3056 Coasial GIehnia Root Extract Coasial GIehnia Root Extract从北沙参Glehnia littoralis Fr. Schmidt ex Miq.(伞形科)干燥的根中提取。
E3059 Piper longum Extract Piper longum Extract是荜茇Piper longum根的水提物,有望预防高血糖、心血管、肝脏和肾脏疾病。
E3060 Dioscorea Sativa Extract Dioscorea Sativa Extract提取自薯蓣科植物萆薢Dioscorea septemloba ThunbtDioscorea hypoglauca Palibin的干燥根茎。
E3064 Polygonum Aviculare Extract Polygonum Aviculare Extract提取自萹蓄Polygonum Aviculare,对MCF-7乳腺癌细胞有较强的细胞增殖抑制作用,诱导凋亡细胞死亡。
E3065 Lentil Extract
E3066 Miraclefruit Extract Miraclefruit Extract是从便秘果(Synsepalum dulcificum)中提取的,它具有降低胆固醇水平的潜力,是降胆固醇剂的天然来源。
E3067 Trionycis Carapax Extract Trionycis Carapax Extract提取自鳖甲Carapax Trionycis,其中分子量小于6 kd (CT6)的Carapax Trionycis提取物可下调TGF-β1诱导的HSC-T6细胞系中TNF-α, IL-1β and IL-6的表达,提示其对肝纤维化有潜在的治疗作用。
E3069 Spinach Extract
E3071 Malaytea Scurfpea Extract
E3072 Paniculata Extract Paniculata Extract是从中药布渣叶(Microcos paniculata L.)中提取的,具有多种生物学功能,包括抗氧化活性和α-葡萄糖苷酶抑制作用。
E3073 Silkworm Chrysalis Extract Silkworm Chrysalis Extract是从蚕bombyx mori茧的蚕蛹中提取而成。
E3074 Xanthium Sibiricum Extract
E3075 Atractylodis Rhizoma Extract
E3076 Brown Rice Extract Brown Rice Extract是从糙米(Oryza sativa)中提取的,它具有有效的抗氧化活性,可缓解导致心力衰竭的因素,例如高血压和糖尿病。
E3077 Tsaoko Fructus Extract
E3078 Sarcandra Glabra Extract Sarcandra Glabra Extract提取自草珊瑚Sarcandra glabra,是一种著名的草药,传统上被用作凉茶或食品补充剂,在中国用于提高精神效率,缓解压力或疲劳。
E3080 Platycladi Cacumen Extract
E3081 Tea Seed Extract Tea Seed Extract是从茶籽(Camellia oleifera)中提取的,具有有效的抗肿瘤活性。
E3082 Bupleurum Extract
E3083 Cicada Slough Extract Cicada Slough Extract从蝉蜕Cicada Slough中提取,可缓解呼吸道疾病的早期或轻微症状,缓解皮疹,眼睛和喉咙不适。
E3084 Hedera Helix Extract
E3085 Dichroae Radix Extract Dichroae Radix Extract提取自常山Dichroae radix,在中医中作为抗疟、祛痰、解热的药物治疗中具有良好的临床疗效,对球虫病感染的鸡单独使用或作为主要中药复方均有抗球虫作用。
E3086 5% Artichoke Leaf EXTRACT 5% Artichoke Leaf EXTRACT 提取自朝鲜蓟(Cynara scolymus),具有抗氧化、利胆、保肝、增强胆汁和降脂作用。
E3087 Artichoke Extract
E3088 Plantaginis Herba Extract Plantaginis Herba Extract是从车前草科植物的干燥全株中提取的,在中医中以促进排尿、治小便涩痛而闻名。
E3089 Plantaginis Semen Extract Plantaginis Semen Extract提取自车前子Plantaginis Semen,具有显著的抗高尿酸血症、抗炎、保护肾脏作用,并通过调节脂质代谢紊乱来减弱氧酸钾诱导的高尿酸血症。
E3090 Aquilariae Lignum Resinatum Extract Aquilariae Lignum Resinatum Extract提取自沉香Aquilariae Lignum Resinatum (瑞香科)的干燥根茎,被广泛用于治疗呕吐、胃痛和胃肠功能障碍。
E3091 Citri Reticulatae Pericarpium Extract Citri Reticulatae Pericarpium Extract提取自陈皮Citri Reticulatae Pericarpium,富含多甲氧基类黄酮,具有显著的抗炎、抗氧化和抗凋亡活性,被认为是治疗代谢紊乱和循环系统疾病的潜在药物。
E3092 Paeoniae Radix Rubra Extract Paeoniae Radix Rubra Extract提取自赤芍Paeoniae Radix Rubra,通过抑制GSK3β活性改善炎症,预防深静脉血栓形成。
E3093 Vignae Semen Extract Vignae Semen Extract是从赤小豆Vignae Semen中提取的,具有利尿缓解水肿,排脓,排毒的作用。
E3094 Flatstem Milkvetch Seed Extract Flatstem Milkvetch Seed Extract是由充蔚子Flatstem Milkvetch的干燥成熟种子提取,有益肝益肾、止精、抑尿、明目之功效。
E3095 Pyrethrum Extract
E3096 Broussonetiae Fructus Extract Broussonetiae Fructus Extract提取自楮实子Fructus Broussonetiae,可显著提高阿尔茨海默病大鼠体内免疫球蛋白结合蛋白的表达,降低PKR样内质网激酶和C/EBP同源蛋白的表达水平,显著改善其学习、记忆和空间识别功能障碍。
E3098 Fritillariae Cirrhosae Bulbus Extract Fritillariae Cirrhosae Bulbus Extract提取自川贝母Fritillariae cirrhosae,通过STAT1STAT4介导的共调控网络介导细胞凋亡,这可能是其抗肿瘤活性的关键新机制。
E3099 Fritillaria Cirrhosa Seed Extract
E3100 Sichuan Pepper Extract
E3101 Toosendan Fructus Extract
E3102 Cyathulae Root Extract Cyathula root extract从川牛膝Cyathulae的根中提取。
E3104 Chuanxiong Rhizoma Extract Chuanxiong Rhizoma Extract从川穹Echinacea Purpurea中提取,应用于食品领域,常作为添加剂使用,具有明显的香味,能促进消化,增加食欲。
E3105 Cochinchina Cudrania Root Extract
E3106 Dioscoreae Nipponicae Rhizoma Extract Dioscoreae Nipponicae Rhizoma Extract提取自穿山龙Dioscorea nipponica的根茎,其主要成分降低IGF-1R中的磷酸化,进而抑制PI3K-AKT和Rap1-MEK信号通路的磷酸化和激活,促进细胞凋亡和格雷夫斯病(Graves’ disease)缓解。
E3107 Andrographis Herba Extract Andrographis Herba Extract提取自穿心莲Andrographis paniculata (Burm. F.) Nees的地上部分,具有多种活性,包括抗菌和抗氧化,抗疟疾,抗血管生成,抗炎,抗糖尿病,和体外α-葡萄糖苷酶和α-淀粉酶抑制活性。
E3109 Cymbidium Extract
E3110 Graviola Extract Graviola Extract是从刺果番荔枝( Annona muricata) 中提取的,对各种人类肿瘤和疾病因子具有治疗作用。
E3111 Tribulus Terrestris Extract
E3112 Rosa Roxburghii Fruit Extract Rosa Roxburghii Fruit Extract 从刺梨(Rosa Roxburghii)的果实中提取,具有通过调节血浆代谢物和肠道微生物预防2型糖尿病的潜力。
E3113 Rosa Roxburghii Root Extract
E3115 Erythrina Variegata Extract Erythrina Variegata Extract从刺桐Erythrina Variegata中提取,是一种民间药物,用于治疗关节炎疼痛。
E3116 Acanthopanax Senticosus Extract Acanthopanax Senticosus Extract提取自刺五加Acanthopanax Senticosus,对小鼠回肠功能具有通过毒蕈碱乙酰胆碱受体(mAChRs)收缩和直接弛缓的双重作用,其弛缓作用可用于治疗腹泻症状,使副交感神经活性增加。
E3117 Amla Extract Amla Extract是从醋栗(Emblica officinalis)的果实中提取的,对炎症、癌症、骨质疏松症、神经系统疾病、高血压等多种疾病以及生活方式疾病、寄生虫病和其他感染性疾病都有疗效。
E3249 Mimosa Pudica Root Extract
E3250 Mimosa Pudica Extract
E3251 Tropaeolum Majus Extract
E3253 Chrysanthemum Morifolium Ramat Extract Chrysanthemum Morifolium Ramat Extract是从杭白菊Chrysanthemum morifolium Ramat中提取的,它在世界范围内很受欢迎,对胰岛素抵抗、炎症和心血管疾病有潜在的作用。
E3254 Terminalia Chebula Extract
E3255 Albiziae Flos Extract Albiziae Flos Extract提取自合欢花Flos albiziae,传统医学用于治疗失眠和焦虑。
E3256 Albiziae Cortex Extract Albiziae Cortex Extract是从合欢皮(Albiziae Cortex/i>)中提取的,具有镇静催眠作用和神经保护作用。
E3257 Polygoni Multiflori Root Extract
E3258 Nelumbinis Folium Extract Nelumbinis Folium Extract是从荷叶Nelumbo nucifera中提取的,具有良好的降血脂、抗氧化和抗炎的生物活性。
E3259 Walnut Extract
E3260 Seminis Juglandis Septum Extract Seminis Juglandis Septum Extract从分心木Diaphragma juglandis中提取,这是核桃仁的干木隔膜,是核桃生产的著名副产品之一。
E3261 Juglandis Semen Extract
E3262 Walnut Leave Extract
E3263 Black Soya Bean Extract Black Soya Bean Extract是从黑豆(Glycine max(L.)merr.)中提取的,其花青素含量高,具有抗氧化和抗蘑菇酪氨酸酶的活性。
E3264 Black Bone Rattan extract
E3265 Black Pepper Extract
E3266 Black Carrot Extract
E3267 Black Coffee Extract
E3268 Black Quinoa Extract
E3269 Black Ant Extract
E3270 Blackberry Extract
E3271 Black Cohosh Extract Black Cohosh Extract是从黑升麻(cimicifuga racemosa)中提取的。
E3272 Black Garlic Extract
E3273 Black Sesame Extract Black Sesame Extract是从芝麻Sesamum radiatum中提取的,这可能是一种有效的改善疾病的膳食补充剂。
E3274 Nigella Sativa Extract (Herb)
E3275 Nigella Sativa Extract (Seed)
E3276 Red Ginseng Extract
E3277 Black Tea Extract
E3278 Black Tea Root Extract
E3279 Kombucha Extract
E3280 Trifolium Pratense Extract
E3281 Eleutherine Plicata Extract Eleutherine Plicata Extract提取自红葱Eleutherine plicata,是一种很有潜力的药用植物,其与caspase-8结合,从而导致细胞毒性。
E3282 Taxus Cuspidata Extract
E3283 Red Bean Extract Red Bean Extract是从红豆中提取的,具有多种功能特性,如抗糖尿病、抗衰老、抗炎、抗癌和保护肝脏等。
E3284 Safflower Extract Safflower Extract是从Carthamus tinctorius L.中提取的,对阿尔茨海默病(AD)的治疗具有积极作用。
E3285 Rhodiola Rosea Extract Rhodiola Rosea Extract是从红景天(Rhodiola Rosea)中提取的。
E3286 Rambutan Extract
E3287 Red Yeast Rice extract
E3288 Red Raspberry Extract Red Raspberry Extract提取自红树莓Rubus idaeus,其中含有丰富的生物活性成分,具有降低氧化应激的作用。
E3290 Citrus Grandis Fruit Extract
E3291 Hydrolyzed Rhodophycea Extract
E3292 Hericium Erinaceus Extract
E3293 Magnolia Bark Extract
E3294 Piper Nigrum Seed Extract Piper Nigrum Seed Extract从胡椒Piper nigrum L.中提取,具有抗菌、抗氧化、抗糖尿病、降血脂、抗炎、镇痛、抗惊厥和神经保护作用。
E3296 Juglans Regia Extract
E3297 Fenugreek Seed Extract Fenugreek Seed Extract是从葫芦巴Trigonella foenum-graecum的种子中提取的,具有抗菌和抗癌的作用。
E3298 Viscum Coloratum Extract
E3019 Semen Ginkgo Extract
E3020 Hedyotic Diffusa Extract Hedyotic Diffusa Extract是从白花蛇舌草Hedyotic diffusa中提取的,Hedyotic diffusa多糖具有抑制CNE2细胞生长的作用,其作用机制可能与诱导细胞凋亡有关,而细胞凋亡与Baxcaspase-3蛋白的激活和Bcl-2蛋白表达的下调有关。
E3021 Chaga Mushroom Extract Chaga Mushroom Extract是从白桦茸Inonotus obliquus中提取的,显示出强大的抗肿瘤活性,在一些国家已被用于治疗癌症。
E3022 Bletilla Striata Root Extract Bletilla Striata Root Extract是从兰科植物白芨Bletilla Striata的根部提取物。
E3023 White Mustard Seed Extract White Mustard (Brassica Alba) Seed Extract是白芥Brassica Alba种子的提取物。
E3024 Ampelopsis Japonica Root Extract Ampelopsis Japonica Root Extract从白蔹Ampelopsis japonica中提取,可能是一种新的治疗药物,具有减少或替代corticosteroids的潜力,其机制与调节TNF-α的产生密切相关。
E3025 Salix Alba Bark Extract Salix Alba Bark Extract从Salix Alba的树皮中提取。
E3026 White Radish Extract White Radish Extract从白萝卜Raphanus sativus中提取,具有抗糖尿病作用。
E3027 Imperata Cylindrica Root Extract Imperata Cylindrica Root Extract提取自白茅根Imperata cylindrica Linn. Beauv (禾本科),在印地语中通常被称为Darbh,是“Trinpanchmool”的一种重要药物,广泛用于治疗各种疾病,如尿结石、尿潴留、糖尿病、心脏疾病、痛风、常见的咳嗽和感冒、炎症、贫血,作为壮阳药等。
E3029 White Paeony Root Extract
E3031 Bunge Auriculate Root Extract Bunge Auriculate Root (Baishouwu) Extract是从中药白首乌Cynanchum auriculatum, Cynanchum bungeiCynanchum wilfordii的块茎中提取而成,是中药材中著名的补药,具有补血滋补、增强免疫力的功效。
E3032 Atractyloides Macrocephala Root Extract
E3033 Pulsatillae Extract
E3001 Donkey-hide gelatin Extract Donkey-hide gelatin Extract来源于阿胶,阿胶是药食同源,可以增强免疫反应,改善代谢平衡,治疗妇科疾病。
E3002 Asafetida Extract Asafetida Extract从新疆阿魏Ferula sinkiangensis K. M. Shen或福建阿魏Ferula fukanensis K. M. Shen中提取而来,具有杀灭肠道蠕虫、治疗寄生虫引起的营养不良、胃腹肿胀疼痛、腹包块、感冒、疟疾、腹泻、预防麻疹等作用。
E3003 Artemisis Princeps Leaf Extract Artemisis Princeps Leaf Extract是从艾叶Artemisia princeps Panpanini中提取的,含有一部分小分子化合物,在体外刺激血管内皮细胞增殖,对促进损伤内皮细胞的恢复有一定的作用。
E3004 Eucalyptus Leaf Extract
E3005 Boesenbergia Pandurata Extract
E3006 Fructus Anisi Stellati Extract Fructus Anisi Stellati Extract从八角Illicium verum果实中提取,参与靶向胃癌细胞癌细胞凋亡、增殖和肿瘤转移的信号通路。
E3007 Marlea platanifolia Extract Marlea platanifolia Extract是从八角枫Marlea platanifoli中提取的,具有抗炎和镇痛活性。
E3008 Eight clawed Golden Dragon extract Eight clawed Golden Dragon extract是从八爪金龙(Ardisia crispa(Thunb.)A.DC.)中提取的,具有抗血管生成作用。
E3009 Morinda Root Extract
E3011 Sarsaparilla Extract
E3012 Semen Lablab Album Extract Semen Lablab Album Extract提取自豆科植物扁豆Dolichos Lablab L.的白色种子。土炒白边豆仁(Baibiandouren, Lablab Semen Album fried with earth, TCBBDR)通过多化合物、多靶点协同作用对糖尿病有治疗作用。
E3013 Chinese Cabbage Extract
E3014 White Tea Extract White Tea Extract是从的白茶Camellia sinensis中提取的,它具有抗炎和抗氧化的特性,对皮肤有保护作用,防止皱纹,晒伤和紫外线损伤。
E3015 Amomum Kravanh Extract
E3016 Cissus modecoides var Extract
E3017 Poria Cocos Extract
E3000 Ligusticum Sinense Extract Ligusticum Sinense Extract来源于中药藁本Ligusticum sinense
E3603 Ramulus Mori Extract Ramulus Mori Extract 来源于桑枝,即植物桑 Morus alba L.的干枝。桑枝是广泛用于治疗糖尿病的传统药物。桑枝的主要活性成分是桑椹苷A、氧化白藜芦醇、白藜芦醇、4-羟基肉桂酸、7-羟基香豆素和桑色素,这些成分已被证明具有抗癌、抗高血压、抗糖尿病和抗炎特性。
E3604 Adenophora Stricta Extract Adenophora stricta Extract 来源于沙参Adenophora stricta Miq.。沙参通常用于化痰、清肺和健胃。
E3605 Sea buckthorn Extract (fruits) Sea buckthorn Extract (fruits)来源于沙棘(Hippophae rhamnoidesL.)果实。沙棘具有显著的心脏保护作用和心血管系统治疗作用,包括抑制血小板活化(特别是血小板聚集),降低胆固醇浓度和血压,提供抗氧化活性。沙棘还具有抗菌和抗病毒特性。
E3606 Sea buckthorn Extract (leaves) Sea buckthorn Extract (leaves)源于沙棘(Hippophae rhamnoidesL.)的叶子。沙棘具有显著的心脏保护作用和心血管系统治疗作用,包括抑制血小板活化(特别是血小板聚集),降低胆固醇浓度和血压,提供抗氧化活性。沙棘还具有抗菌和抗病毒特性。
E3607 Crateva nurvala Extract Crateva nurvala Extract来源于沙梨木Crataeva nurvala Buch. 的树皮。沙梨木是一种重要的药用植物,其茎皮部分主要用于阻塞性和非阻塞性尿路病的研究。沙梨木也用于治疗前列腺肿大和恢复膀胱敏感性。
E3608 Semen astragali complanati Extract Semen astragali complanati Extract来源于沙苑子,即扁茎黄芪Astragalus complanatus Bunge的干燥成熟种子。沙苑子的主要成分包括脂肪酸,氨基酸,多糖,类黄酮,三萜糖苷和微量元素。沙苑子对心血管疾病,糖尿病和癌症等慢性疾病表现出治疗效果。
E3609 Elaeagnus angustifolia Extract Elaeagnus angustifolia Extract来源于沙枣Elaeagnus angustifolia L.的果实。沙枣果实提取物具有急性和慢性抗炎活性。
E3610 Amomum villosum Extract Amomum villosum Extract来源于姜科草本植物砂仁Amomum villosum Lour.。砂仁已被证实可有效治疗肠胃疾病。砂仁水提取物显著减轻炎症性肠病大鼠的肠道炎症。
E3611 Camellia japonica Extract Camellia japonica Extract是山茶花 Camellia japonica L.的花朵。山茶花具有抗菌、抗氧化和抗肿瘤活性,并且是多酚类物质(如儿茶素)的重要来源。
E3612 Cremastra appendiculata Extract Cremastra appendiculata Extract来源于山慈菇 Cremastra appendiculata (Pseudobulbus Cremastrae seu Pleiones)。山慈姑是兰科植物的干燥假鳞茎。山慈菇具有抗菌、抗高血压、治疗痛风、抗肿瘤和乙酰胆碱受体M3阻断作用。山慈菇提取物可用于治疗肺癌、肝癌和乳腺癌。
E3613 Sophora tonkinensis Extract Sophora tonkinensis Extract 来源于豆科植物越南槐Sophora tonkinensis Gapnep.的干燥根茎。山豆根用于治疗咽喉疾病。山豆根具有保肝、免疫调节和抗癌作用,对肝脏、神经和心血管系统有明显毒性。
E3614 Arnica montana Extract Arnica montana Extract是从菊科植物山金车Arnica montana L.的花中提取的。山金车具有抗炎、免疫调节、抗硬化、镇痛、抗真菌、抗氧化、抗菌和抗癌的生物活性。
E3616 Kaempferia galanga Extract Kaempferia galanga Extract提取于姜科植物山奈Kaempferia galanga L.。山奈用于缓解消化不良、肿胀、疼痛、高血压和血脂异常。
E3617 Galega officinalis Extract Galega officinalis Extract是从山羊豆Galega officinalis L.种子中提取的。山羊豆提取物具有降血糖和抗氧化作用。
E3618 Yam Extract Yam Extract 来源于中国山药,即各种薯蓣科山药属植物 Dioscorea opposita Thunb.的根茎。山药主要含有蛋白质、糖、维生素、脂肪、胆碱、淀粉酶、碘、铁、钙、磷等人体不可缺少的微量元素。山药的主要药理作用包括抗氧化、抗衰老、抗肿瘤、降血糖等。山药还能增强免疫力。
E3619 Lonicerae Flos Extract Lonicerae Flos Extract 是从忍冬科植物山银花Lonicera japonica的花蕾中提取的。山银花是一种传统中药,用于治疗炎症和传染病。金银花提取物提高盲肠结扎和穿刺诱导的脓毒症大鼠的存活率。
E3620 Corni Fructus Extract Corni Fructus Extract是从山茱萸Cornus officinalis Sieb. et Zucc.果实中提取的。山茱萸是一种中药,具有抗炎、糖尿病肾病、肿瘤、抗氧化和抗衰老的药理作用。
E3621 Crataegi fructus Extract Crataegi fructus Extract是从山楂果实中提取的。山楂是植物山里红Crataegus pinnatifida Bge.var. major N. E. Br.或山楂Crataegus pinnatifida Bge.的成熟果实。山楂提取物和其中的化合物具有多种药理活性,例如对心力衰竭患者的保护作用,以及增强心肌收缩力、改善冠状动脉循环、抗氧化作用和抗菌活性。
E3623 Pelargonium hortorum Extract Pelargonium hortorum Extract是从天竺葵Pelargonium hortorum L.H. Bailey中提取的。天竺葵属被报道是金属超积累植物。天竺葵属植物能酸化土壤pH值。天竺葵有在芽中积累铅的能力。
E3624 Phytolaccae Radix Extract Phytolaccae Radix Extract是从商陆(Phytolacca acinosa Roxb.或 Phytolacca americana L.)的干燥根中提取的。商陆被广泛用于治疗炎症相关疾病。
E3625 Cnidii Fructus Extract Cnidii Fructus Extract 是从蛇床子Cnidium monnieri (L.)Cuss.的干燥成熟果实中提取的。中药蛇床子对慢性腰痛和阳痿有显著疗效,也常被用于治疗骨质疏松症。
E3626 Snake Gallbladder Extract Snake Gallbladder Extract 是从蛇胆中提取的。蛇胆具有多种药理作用,如缓解咳嗽和哮喘,以及提高人体免疫力和视力。在亚洲各国,蛇胆被认为可以提高视力和缓解风湿病。
E3627 Belamcandae Rhizoma Extract Belamcandae Rhizoma Extract 提取于植物射干Belamcanda chinensis (L.) DC.的干燥根茎。射干主要用于治疗咽喉痛、支气管炎和慢性气管炎。从射干根茎中提取的异黄酮,包括野鸢尾苷元,被认为不仅具有抗氧化和抗炎作用,而且还具有抗肿瘤活性。
E3629 Lycopodii Herba Extract Lycopodii Herba Extractt提取自伸筋草,即干燥的石松科植物石松Lycopodium japonicum Thunb.的全株。石松具有抗炎、抗氧化、抗肿瘤活性;传统上用于预防和治疗各种疾病,如类风湿性关节炎、挫伤、四肢瘫痪、痛经。
E3630 Massa Medicata Fermentata Extract
E3631 Cimicifugae Rhizoma Extract
E3632 Rehmanniae Radix Extract
E3633 Ginger Extract
E3634 Ginger Extract(1%)
E3635 Chasteberry Extract
E3636 Ocimum sanctum Extract
E3637 Acorus tatarinowii Extract
E3638 Lysinotus pauciflorus Extract
E3639 Gypsum fibrosum Extract
E3640 Dendrobii caulis Extract
E3641 Salvia Chinensis Benth Extract
E3642 Haliotidis concha Extract
E3643 Pomegranate Peel Extract
E0840 Yakuchinone A Yakuchinone-A是从姜科植物益智中分离得到的一种天然产物,对前列腺素(prostaglandins,PGs)白三烯(leukotrienes,LTs)的合成有很强的抑制作用。
E2012 Ginkgolide K Ginkgolide K通过AMPK/mTOR/ULK1信号通路诱导保护性自噬,具有神经保护作用。
S0970 Curzerene Curzerene是从仙茅根茎中分离得到的具有抗癌活性的倍半萜类化合物,可抑制谷胱甘肽S-转移酶A1(GSTA1)的mRNA和蛋白表达,也可诱导细胞凋亡。
E0583 Isoscabertopin

Isoscabertopin is a sesquiterpene lactone isolated from <i>Elephantopus scaber L</i> and shows anti-tumor activities.

E0543 OJV-VI

OJV-VI is isolated from <i>ophiopogonis</i>.

E2023 Hypocrellin B

Hypocrellin B is a natural product isolated from the fungi <i>Hypocrella bambusae</i> and <i>Shiraia bambusicola</i> with the induction of apoptosis.

S6370 Dendrophenol Dendrophenol (Moscatilin) 是一种来自石斛的天然的双苄基化合物,具有潜在的抗诱变活性。
S0938 Sakuranetin Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties.
E0505 Olive oil Olive oil来自欧洲橄榄油树Olea europae的果实,对人体健康有有益的影响,具有抗氧化活性和抗炎活性。
E0506 Soybean oil 大豆油是一种从大豆种子中提取的大豆植物油。
E0656 7-Methylcoumarin 7-Methylcoumarin can inhibit the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8–3.6 μg/ml, and also has a strong hepatoprotective activity.
E0748 Opoponax oil Opoponax oil是从Commiphora erythraea (opoponax)中分离提取的,具有很好的杀虫性能。
E1124 Narciclasine Narciclasine (Lycoricidinol)是一种异羧基生物碱,在他莫昔芬耐药的乳腺癌细胞中通过不同的机制靶向STAT3。Narciclasine通过直接与STAT3 SH2结构域结合,抑制STAT3的磷酸化、激活、二聚和核易位,导致STAT3降解。Narciclasine是一种植物生长调节剂。Narciclasine调节Rho/Rho激酶/LIM激酶/cofilin信号通路,显著增加GTPase RhoA活性,并以RhoA依赖的方式诱导肌动蛋白应激纤维的形成。
E0650 γ-Terpinene γ-Terpinene (γ-TPN)是一种单萜类物质,是一种口服活性抗氧化剂化合物,可直接清除自由基。
E0651 Garlic oil Garlic oil通过诱导II期药物代谢酶阻断烟草致癌物4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone(NNK)诱导的肺肿瘤发生。
S4448 Imidacloprid-urea Imidacloprid-urea with a role as a marine xenobiotic metabolite, is the primary imidacloprid soil metabolite, whereas imidacloprid-olefin is the main plant-relevant metabolite and is more toxic to insects than imidacloprid.
E0653 Trans-ferulic acid Trans-ferulic acid是高糖条件下AMPK的强效激活剂。
E0478 Procyanidin C1 Procyanidin C1是葡萄籽提取物中的一种多酚类成分,通过其对衰老细胞的作用,增加了小鼠的健康寿命和寿命。PCC1是一种具有体内活性的天然感官治疗药物,它可能是一种延缓、缓解或预防年龄相关病理的潜在干预手段。
S0936 Aloin B Aloin B (Isobarbaloin)是从芦荟中分离出来的,是Aloin的一种异构体,具有抗乙型肝炎病毒(HBV)的活性。
S0944 Benzoylaconitine Benzoylaconitine (Isaconitine, Pikraconitin)是从中药附子中提取的一种生物碱,在IL-1β诱导的人滑膜细胞中,可通过MAPK、Akt、NF-κB信号抑制IL-6和IL-8的产生。
E0239 (-)-Catechin gallate (-)-Catechin gallate ((-)-CG)是一种在绿茶提取物中发现的儿茶素多酚,具有多种生物活性。
E0240 Procyanidin B1 Procyanidin B1是一种具有抗氧化特性的天然多酚类化合物,可抑制Kv10.1通道(Kv10.1 channel)进而抑制肝癌的发展。
E0241 Asiaticoside B

Asiaticoside B is a triterpene glycoside isolated from Centella asiatica (L.) Urban, with anti-cancer activity.

E0242 Picrocrocin Picrocrocin是产生藏红花苦味的化学物质,从藏红花中分离出来,可以抑制癌细胞的增殖。
E0243 Emodin-8-glucoside Emodin-8-glucoside (Emodin glucoside B, Anthraglycoside B, Emodin glucoside B)是从芦荟中分离出来的蒽醌衍生物,与DNA的小凹槽结合。
E0244 Acevaltrate Acevaltrate是一种来自草本植物缬草的活性成分,对GBM细胞凋亡的诱导具有显著的诱导作用。Acevaltrate抑制大鼠肾脏和脑半球Na+/K+-ATPase活性,IC50分别为22.8 μM和42.3 μM。
E0246 β-Anhydroicaritin β-Anhydroicaritin是从Boswellia carterii Birdware中分离出来的,具有抗骨质疏松、雌激素调节和抗肿瘤特性。
E0247 Militarine Militarine是白芨块茎的主要化学成分,具有显著的神经保护作用。
E0248 Rehmannioside D (Rhmannioside D) Rehmannioside D (Rhmannioside D)是地黄中的一种环烯醚萜苷成分。
E0249 Pseudolaric Acid A Pseudolaric acid A,一种Hsp90抑制剂,在HL-60、A549、SMMC-7721、HeLa和SW480细胞中的IC50分别为0.60μM、2.72μM、1.36μM、2.92μM和6.16μM,Pseudolaric acid A是土荆皮的主要生物活性成分,诱导细胞周期阻滞在G2/M期,通过caspase-8/caspase-3途径促进细胞死亡,具有有效的抗增殖和抗癌活性。
E0212 Cornuside Cornuside 是一种从 Cornus officinalis SIEB. et ZUCC 果实中分离出来的双环烯醚萜苷化合物。Cornuside 通过抑制 RAW 264.7 巨噬细胞中的 NF-κB 活化来抑制脂多糖诱导的炎症介质。Cornuside 减弱大鼠皮质神经元的细胞凋亡。
E0213 Bruceine D Bruceine D,从灌木 Brucea javanica (L.) Merr. (Simaroubaceae) 中分离出来,在各种人类癌症中具有抗肿瘤特性,包括胰腺癌、乳腺癌、肺癌、血液癌、骨骼癌和肝癌。Bruceine D 通过线粒体途径诱导人慢性粒细胞白血病 K562 细胞凋亡。
E0215 Isorhapontigenin Isorhapontigenin (ISOR) ,从 Belamcanda chinensis 中分离出来,是二苯乙烯的衍生物。Isorhapontigenin 具有有效的抗氧化活性。Isorhapontigenin 抑制白细胞介素 1β 诱导的大鼠软骨细胞炎症和软骨基质损伤。
E0216 Hinokiflavone Hinokiflavone,从 Selaginella P. Beauv、Juniperus phoenicea 和 Rhus succedanea 中分离得到,具有优异的药理活性,包括抗炎、抗氧化和抗肿瘤活性。Hinokiflavone 通过 EMT 信号通路诱导细胞凋亡并抑制乳腺癌细胞的迁移。
E0190 Invert sugar Invert Sugar是一种流行的甜味剂。
E0211 Dihydroberberine Dihydroberberine是小檗碱 (BBR) 的氢化衍生物,通过双重调节 NF-κB 和 MAPK 信号通路发挥抗炎作用。
S0941 3,29-O-dibenzoyloxykarounidiol 3,29-O-dibenzoyloxykarounidiol 是一种从 Trichosanthes kirilowii Maxim 中分离出来的三萜类化合物。
S5813 Isoginkgetin Isoginkgetin是一种天然来源的双黄酮,具有抗肿瘤活性。Isoginkgetin 直接抑制 20S 蛋白酶体 (proteasome) 的糜蛋白酶样、胰蛋白酶样和半胱天冬酶样活性。Isoginkgetin 也是 Pre-mRNA 剪接(splicing) 的通用抑制剂。
S0958 Zingibroside R1 Zingibroside R1 从 Panax zingiberensis Wu et Feng(五加科)的根茎中分离得到,具有一定的抗 HIV-1 活性。Zingibroside R1 显示对 EAT 细胞摄取 2-脱氧-D-葡萄糖 (2-DG) 的抑制作用,IC50 为 91.3 µM,对 MT-4 细胞的生长具有抑制作用,CC50 为 46.2 µM。
E0206 Ginkgetin Ginkgetin 是一种来自银杏叶的双黄酮,具有抗癌、抗炎、抗微生物、抗脂肪生成和神经保护作用。
E0207 Chebulinic acid Chebulinic acid,一种从榄仁树果实中分离的酚类化合物,是一种新型流感病毒神经氨酸酶(Influenza viral neuraminidase)抑制剂。Chebulinic acid 也是一种抗血管生成剂,通过抑制 VEGF 起作用。Chebulinic acid 具有抗肿瘤活性。
E0208 Herbacetin Herbacetin 是一种存在于亚麻籽中的天然类黄酮化合物,具有很强的抗氧化、抗肿瘤和抗炎活性。
E0209 Cinobufotalin Cinobufotalin,可从巨蟾的皮肤分泌物中提取,是一种新型的 SREBP1 抑制剂,通过靶向脂肪生成来抑制肝细胞癌的增殖。
E0210 Quercetin 3-O-β-D-glucuronide Quercetin 3-O-β-D-glucuronide (Miquelianin, Q3GA)是槲皮素代谢物之一,具有抗氧化活性。
E0222 Glaucocalyxin A Glaucocalyxin A 是一种从 Rabdosia japonica var 中分离出来的具有生物活性的 ent-kauranoid 二萜。Glaucocalyxin A具有抗肿瘤和抗炎活性。Glaucocalyxin A 通过人膀胱癌细胞中的 PI3K/Akt 通路诱导 G2/M 细胞周期停滞和凋亡。
E0225 Licochalcone B Licochalcone B (Lico B),从 Glycyrrhiza uralensis Fisch 中提取出来,可诱导人肝癌细胞 HepG2 的细胞周期停滞和凋亡。Licochalcone B 通过破坏 NEK7-NLRP3 相互作用特异性抑制 NLRP3 炎性体
E0226 Chebulagic acid Chebulagic acid 是从 Terminalia chebula Retz 中分离出来的,是一种可逆的、非竞争性的麦芽糖酶(maltase)抑制剂,Ki 值为 6.6 μM。Chebulagic acid 在 LPS 刺激的 RAW 264.7 细胞中显示出有效的抗炎作用。Chebulagic acid 还显示出有效的 COX-LOX双重抑制活性,对 COX-1、COX-2 和 5-LOX 的 IC50 值分别为 15 μM、0.92 μM 和 2.1 μM。
E0233 14-Deoxy-11,12-didehydroandrographolide 14-Deoxy-11,12-didehydroandrographolide (deAND),一种在穿心莲 (Burm. f.) Nees 中的二萜类化合物,具有降血压、抗炎、抗哮喘和抗癌活性。
E0177 Hydrocortisone sodium succinate Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) 对 IL-6 的生物活性有显着的抑制作用,IC50 为 6.7 μM。Hydrocortisone sodium succinate 可与糖皮质激素受体(glucocorticoid receptor) 结合,启动抗炎和免疫抑制介质的转录。
E0201 Hypaconitine Hypaconitine (Deoxymesaconitine) 是一种从乌头属植物中提取的活性二萜生物碱。次乌头碱抑制 TGF-β1 诱导的上皮间质转化。
E0202 Benzoylmesaconine Benzoylmesaconine (Mesaconine 14-benzoate) 是一种主要的乌头生物碱,从几种乌头属植物中分离出来,具有很强的药理活性,如镇痛和抗炎。
E0204 Poricoic acid A Poricoic acid A 是从茯苓的表层中分离出来的 Poricic acid A 激活 AMPK 以减弱肾纤维化中的成纤维细胞活化和异常细胞外基质重塑。Poricic acid A 也是色氨酸羟化酶-1 (tryptophan hydroxylase-1, TPH-1) 的调节剂。
E0205 Strictosamide Strictosamide 是 Nauclea of​ficinalis Pierre ex Pitard(茜草科)的主要代表性成分,具有抗炎和镇痛活性。
S7758 Trabectedin Trabectedin (Ecteinascidin 743, ET-743) 是一种从加勒比被囊动物 Ecteinascidia turbinata 中分离出来的具有抗肿瘤活性的海洋生物碱。Trabectedin 与小沟中鸟嘌呤的 N2 结合,导致 DNA 损伤并以启动子和基因特异性方式影响转录调控。
S0651 N-Butanoyl-L-homoserine lactone N-Butyryl-L-homoserine lactone (N-Butanoyl-L-homoserine lactone, N-Butyrylhomoserine lactone, C4-HSL) 是一种可切割的ADC接头,用于合成抗体药物偶联物(ADC)。N-Butyryl-L-homoserine lactone是一种小的可扩散信号分子,参与群体感应、控制基因表达和细胞代谢。
E0160 Hexaminolevulinate hydrochloride Hexaminolevulinate hydrochloride (5-Aminolevulinic acid hexyl ester hydrochloride)是一种肿瘤光敏剂。
E0365 Fucoidan Fucoidan是从海洋褐藻中提取的阴离子硫酸化多糖,具有广泛的生物活性,包括抗炎、抗癌、抗病毒、抗氧化、抗凝、抗血栓、抗血管生成和抗幽门螺杆菌等。
S0920 Ginkgolide J Ginkgolide J 是银杏叶提取物萜烯三内酯混合物的次要成分,可抑制 GlyR 控制的通道,IC50 为 2.0 μM。Ginkgolide J 还抑制由 Aβ1-42 引起的啮齿动物海马神经元的细胞死亡。银杏内酯 J 具有抗炎活性。
E0198 Pristane Pristane (2,6,10,14-Tetramethylpentadecane, TMPD) 是一种天然的饱和萜类烷烃,主要从鲨鱼肝油中提取,广泛用于诱导小鼠的肿瘤发生和大鼠的关节炎和狼疮性肾炎。
E1029 Miglustat Miglustat (Zavesca, N‐butyldeoxynojirimycin, OGT 918) 是一种口服神经酰胺葡糖基转移酶(ceramide glucosyltransferase)抑制剂,可防止葡糖脑苷脂的溶酶体积聚。
E0196 Alloxan Monohydrate Alloxan Monohydrate是最常用的致糖尿病药物,用于评估测试化合物的抗糖尿病或降血糖能力。
S9793 4-Hydroxynonenal 4-Hydroxynonenal (4-HNE, HNE, 4-hydroxy Nonenal, 4-hydroxy-2-nonenal) 是脂质过氧化的主要终产物之一,已被广泛接受为氧化应激的诱导剂。
E0150 Carrageenan Carrageenan (kappa-Carrageenan) 是一种从食用红海藻中提取的天然碳水化合物(多糖)。Carrageenan具有抗凝活性、抗血栓形成活性、抗病毒活性、抗肿瘤活性和免疫调节活性。
E0149 Papain Papain (papaya proteinase I) 是一种来自木瓜果实乳胶的巯基蛋白酶。Papain可分解软骨的细胞间基质。
E0156 Thioacetamide Thioacetamide (TAA) 是一种常用于实验目的的肝毒素,单次给药后会导致小叶中心坏死。
E0154 Taurocholic acid sodium salt Taurocholic acid sodium salt (Sodium Taurocholate, TANa)是牛磺胆酸的钠盐形式,存在于哺乳动物的胆汁中。Taurocholic acid用作利胆剂和利胆剂。
E0143 ITE ITE (2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester)是一种有效的芳烃受体 (AhR) 内源性激动剂,可直接与 AHR 结合,Ki 为 3 nM。
S6812 Z-Guggulsterone Z-Guggulsterone 是阿育吠陀药用植物 Commiphora mukul 的一种成分,在体外和体内抑制血管生成。Z-Guggulsterone 在小胶质细胞中具有抗炎作用。Z-Guggulsterone 通过内在的线粒体依赖性途径诱导胃癌细胞凋亡。
E0129 Oxysophocarpine Oxysophocarpine (OSC) 是从 Sophora alopecuroides 中提取的生物碱。Oxysophocarpine 通过靶向 Nrf2/ HO-1 轴抑制口腔鳞状细胞癌 (OSCC) 的生长和转移。OSC 通过减弱 MAPK 来保护细胞免受细胞凋亡炎症反应并削弱 miR-155 活性和 NF-κB 通路。
E0130 Apigenin-7-O-glucuronide Apigenin-7-O-glucuronide (Apigenin-7-glucuronide) 是在奶蓟中发现的主要黄酮类化合物。Apigenin 7-o-glucuronide 抑制脂多糖激活的巨噬细胞中的肿瘤坏死因子 α (TNF-α) 和总亚硝酸盐释放。
E0015 Iberiotoxin Iberiotoxin (IbTX) 是从蝎子 Buthus tamulus 中纯化的毒素。Iberiotoxin 是大电导 Ca(2+)-activated K+ channel的有效阻滞剂,Kd 约为 1 nM。
S0947 Cafestol Cafestol是从咖啡豆中提取的天然二萜。Cafestol 诱导细胞凋亡并调节多种炎症介质以减轻炎症。Cafestol 抑制 PI3K/Akt 通路。Cafestol 还可以减少白血病细胞系 HL60 中 ROS 的产生。
E0023 5,7-Dihydroxychromone 5,7-Dihydroxychromone (DHC) 是一种从植物中提取的天然抗氧化剂,是 Nrf2/ARE 信号的有效激活剂。5,7-Dihydroxychromone也是 PPARγ 和 LXRα 的有效激活剂。5,7-二羟基色酮可能有助于调节血糖水平并显示抗糖尿病特性。
E0046 β-Cyclodextrin β-Cyclodextrin (β-CD, Beta-Cyclodextrin) 是一种淀粉的环状衍生物,由部分水解淀粉(麦芽糖糊精)通过酶促过程制备。β-Cyclodextrin可用作络合剂以增加难溶性药物的水溶性并增加其生物利用度和稳定性。
E0124 Chelerythrine Chelerythrine (Toddaline, Broussonpapyrine) 是一种有效的选择性 PKC 拮抗剂,IC50 为 0.66 μM。 Chelerythrine 还抑制 BclXL-Bak BH3 肽结合,IC50 为 1.5 μM。 Chelerythrine 具有抗肿瘤、抗糖尿病和抗炎活性。
S8152 Cucurbitacin I Cucurbitacin-I (Elatericin B, JSI 124, NSC 521777),一种从葫芦科植物中分离出来的天然细胞渗透性三萜,是一种新型的 JAK2/STAT3 选择性抑制剂。
S7580 Leptomycin B Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) 是一种从链霉菌中分离的强效抗真菌抗生素,可作为核输出因子 CRM1 的特异性抑制剂。 Leptomycin B 通过共价抑制 CRM1 快速诱导癌细胞系的细胞毒性作用,IC50 值为 0.1 nM–10 nM。
E0037 Bradykinin Bradykinin是一种有效的血管扩张肽,通过刺激特定的内皮 B2 受体发挥其血管扩张作用,从而导致前列环素、NO 和 EDHF 的释放。
S0950 Hibifolin Hibifolin (Gossypetin-8-O-β-D-glucuronide) 是一种黄酮醇糖苷,是 腺苷脱氨酶 (adenosine deaminase, ADA) 的潜在抑制剂,Ki 为 49.92 μM。 Hibifolin 在培养的皮层神经元中防止 β-淀粉样蛋白诱导的神经毒性。
E0010 Hypocrellin A Hypocrellin A (HA) 是一种从 Shiraia bambusicola 中分离的苝醌,显示出抗病毒、抗菌和抗癌的活性。Hypocrellin A 还是 PKC 的选择性和有效抑制剂。
E0027 5-Hydroxymethylcytosine 5-Hydroxymethylcytosine (5hmC) 是哺乳动物基因组DNA中天然存在的成分,被认为是DNA的第六个碱基。5-Hydroxymethylcytosine是活性 DNA 去甲基化的中间代谢物。5-Hydroxymethylcytosine是已知会影响哺乳动物全局基因表达的表观遗传标记。
E0025 2-Hydroxybenzylamine 2-Hydroxybenzylamine (2-(Aminomethyl)phenol, 2-HOBA, NSC 127870) 是一种天然存在于荞麦中的化合物,是二羰基亲电试剂的选择性清除剂,可保护蛋白质和脂质不被这些亲电试剂修饰。2-HOBA 可减少炎症和斑块凋亡细胞,并促进胞吐作用和稳定斑块的特征。2-HOBA 具有用作营养补充剂的潜力,因为它能够防止氧化的破坏作用。
E0008 Atractylodin Atractylodin (Atractydin) 是 Atractylodes lancea 根茎的主要成分之一,抑制 N-酰基乙醇胺水解酸酰胺酶 (NAAA) 的活性,IC50 为 2.81 µM。Atractylodin 还通过阻断 NPM-ALK 激活和 MAPK 来抑制白细胞介素 6 (IL-6)
E0009 Harmane Harmane (Harman, Aribine, Aribin, Locuturine, Locuturin, Loturine, Passiflorin, 1-Methylnorharman, NSC 54439)是多种食品、植物和饮料中的常见化合物。Harmane 是一种选择性 monoamine oxidase 抑制剂,对人 MAO A 和 MAO B 的 IC50 分别为 0.5 μM 和 5 μM。Harmane还可以抑制噬菌体 T4 诱导的紫外线核酸内切酶(UV endonuclease)的 无嘌呤/无嘧啶核酸内切酶(apurinic/apyrimidinic (AP) endonuclease) 活性。
E0022 Ophiopogonin D Ophiopogonin D (OJV-VI, Deacetylophiopogonin C) 是一种从中草药麦冬中分离得到的甾体糖苷,具有抗肿瘤作用。Ophiopogonin D 可通过调节 ITGB1/FAK/Src/AKT/β-catenin/MMP-9 信号轴抑制TGF-β1介导的MDA-MB-231细胞转移行为。Ophiopogonin D 还通过抑制小鼠肺上皮细胞中的 AMPK/NF-κB 通路来减轻 PM2.5 诱导的炎症。
S9197 Maltohexaose Maltohexaose(Amylohexaose)是一种含有6个葡萄糖单位的多糖,可归类为麦芽糊精。
S0943 Arenobufagin Arenobufagin是蟾蜍毒液中的天然蟾蜍二烯内酯,通过抑制 PI3K/Akt/mTOR 通路诱导人肝癌细胞凋亡和自噬。
S6909 Levomefolic acid Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) 是一种天然的活性叶酸形式,在细胞水平上用于 DNA reproduction、半胱氨酸循环和同型半胱氨酸的调节等功能。
S6927 Dihydroresveratrol Dihydroresveratrol 是一种具有显著生物活性的天然产物,一种有效的植物雌激素,是 hormone receptor 的调节剂。
S3166 Calcium 2-oxoglutarate Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) 是2-oxoglutarate的钙盐形式。2-oxoglutarate 是自然存在于生物中的,是众所周知的在柠檬酸循环(Krebs cycle)中ATP或GTP产生的中间体。2-oxoglutarate 是 tyrosinase 的可逆抑制剂,其IC50值为15 mM。
S6100 Picrotoxin Picrotoxin (Picrotin, Cocculin, Cocculus, NSC 403139) 是一种植物生物碱,是神经元 GABAglycine receptors 的非竞争性拮抗剂。
S5910 Alpha-Estradiol Alpha-Estradiol (α-Estradiol, 17 alpha-Estradiol, Alfatradiol, Epiestradiol, Epiestrol, Alora, 17 α-E2) 是一种天然的、非雌性化,是生理上几乎无活性的激素17β-雌二醇(17β- E2)的立体异构体,是雌激素 estrogen 的弱抑制剂。
S3761 Eucalyptol Eucalyptol (NSC 6171, 1,8-Cineol, 1,8-cineole, 1,8-Epoxy-p-menthane, 1,8-Oxido-p-menthane, Cineol, Cineole) 是存在于许多植物,主要是桉树种,中的单萜类油,具有抗炎和抗氧化作用。Eucalyptol 通过抗炎细胞因子的抑制作用来控制气道的粘液分泌过多和哮喘。
S5417 Spectinomycin dihydrochloride pentahydrate Spectinomycin dihydrochloride pentahydrate (Trobicin) 是一种广泛使用的抗生素,可通过阻止信使RNA的易位和核糖体上的转移RNA来抑制细菌蛋白质的合成。
S5972 Hydrocortisone hemisuccinate Hydrocortisone hemisuccinate (A-hydrocort, Hydrocortisone 21-hemisuccinate) 是一种具有抗炎特性的生理性糖皮质激素,是 proinflammatory cytokine 的抑制剂,对 Interleukin-6 (IL-6)IL-3 的IC50值分别为6.7 μM和21.4 μM。
S9827 Iodoacetamide Iodoacetamide (IA, IAM, 2-Iodoacetamide) 是一种烷基化剂,通常在蛋白质组学样品制备过程中用于半胱氨酸的烷基化。
S5958 Metformin Metformin (1,1-Dimethylbiguanide) 是一种广泛用于治疗2型糖尿病的药物,可激活肝细胞中的 AMP-activated protein kinase (AMPK)。Metformin 可促进单核细胞中的线粒体自噬。Metformin 可通过激活 JNK/p38 MAPK 途径和GADD153来诱导肺癌细胞凋亡。
S5937 DL-Carnitine DL-Carnitine ((±)-Carnitin) 是L-Carnitine和D-Carnitine的外消旋混合物,可调节线粒体中的 fatty acid transport。DL-Carnitine 被发现对肌肉细胞和心肌无效或有毒。DL-Carnitine 可引起肌无力和心律不齐的症状。
S5955 Thiamine nitrate Thiamine (Vitamin B1) nitrate 是一种必需的维生素,它在细胞从摄入食物中产生能量时发挥重要作用,并可增强正常的神经元活性。
S5888 Beclamide Beclamide (N-Benzyl-3-chloropropionamide, beta-chlorpropionamide) 具有镇静和抗惊厥作用。
S5199 Oxytetracycline hydrochloride Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride 是一种抗生素,会干扰细菌产生必需蛋白质的能力。
S4486 Thiamine monochloride Thiamine (Vitamin B1) monochloride 是一种必不可少的维生素 vitamin,它在摄取食物的细胞能量生产中起着重要作用,并能增强正常的神经元活性。
S4495 Quinine Quinine 是一种来自cinchona tree的生物碱,是一种抗疟疾剂和钾通道 potassium channel 的抑制剂,可抑制电压诱发的mSlo3 (KCa 5.1)通道电流,脉冲至+100 mV,其IC50值为169 μM。
S4490 Tetracycline Tetracycline (TC) 是一种广谱的抗生素,对多种微生物具有活性,包括革兰氏阳性和革兰氏阴性细菌、衣原体、支原体、立克次氏体和原生动物寄生虫。
S3590 Triolein Triolein 是一种 metalloproteinase-1 (MMP-1) 的抑制剂,可降低辐射角化细胞中 IL-6ROS 的表达。
S4713 Atropine Atropine (Atropen, Atnaa, Tropine tropate, DL-Hyoscyamine) 是一种具有竞争性的 muscarinic acetylcholine receptor (mAChR) 的拮抗剂,具有抗近视作用。
S5193 L-Thyroxine sodium salt pentahydrate L-Thyroxine (Levothyroxine, L-T4) sodium salt pentahydrate 是一种合成的T4激素,可用于平衡甲状腺功能减退症。
S5260 ATP ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) 是一种多功能的三磷酸核苷,是免疫和炎症反应中重要的内源性信号分子。
S5790 Folinic acid Folinic acid (Leucovorin) 是一种生物叶酸,可增加组织中叶酸还原的水平,从而促进对 thymidylate synthase (TS) 的抑制。
S6466 Eicosapentaenoic acid ethyl ester Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) 是omega-3 fatty acid 药剂,可显著地降低 triglyceride (TG) 的水平并改善其他脂质参数而不会显着增加低密度脂蛋白(LDL)胆固醇的水平。
S4979 Procaine penicillin G Penicillin G Procaine (PGP, Penicillin G Procaine, Bicillin C-R) 是一种将青霉素G与Procaine相结合的结晶复合物,一种β-内酰胺抗生素。
S5922 L-Carnitine hydrochloride L-Carnitine ((R)-Carnitine, Levocarnitine) hydrochloride 可改善氧饱和度,并抑制 leukotriene 的合成。L-Carnitine hydrochloride 的功能是将长链脂肪酰基辅酶A转运到线粒体中,以通过β氧化降解。
S0911 Hypaphorine Hypaphorine 大量存在于王不留行vaccaria semen中,通过抑制 ERK 或/和NFκB信号通路来抵消炎症。
S4857 L-Ornithine L-ornithine ((S)-2,5-Diaminopentanoic acid) 通过增加能量消耗的效率及促进氨的排泄而具有抗疲劳的作用。它是尿素循环中的关键反应物之一。
S3578 Pyrroloquinoline quinone Pyrroloquinoline quinone (PQQ, Methoxatin) 是一种天然的抗氧化剂,具有抗氧化和抗衰老的作用。Pyrroloquinoline quinone 可预防雌激素缺乏引起的骨质疏松症。
S4496 Maltose monohydrate Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose) monohydrate 是一种非必需营养素,可提供能量,是糖原和淀粉在肠内消化的中间产物,存在于发芽的谷物以及其他植物和蔬菜中。
S9631 Puromycin aminonucleoside Puromycin aminonucleoside (NSC 3056, PAN, Stylomycin aminonucleoside, ARDMA, SAN) 是抗生素puromycin的氨基核苷部分,是 dipeptidyl-peptidase IIcytosol alanyl aminopeptidase 的可逆抑制剂,会在系膜细胞(MCs)中诱导凋亡,并伴有细胞活力下降和炎症反应增强。
S7428 Rocaglamide Rocaglamide (Roc-A) 是从Aglaia物种中分离出来的一种有效的 heat shock factor 1 (HSF1) 活化的抑制剂,对HSF1的IC50值约为50 nM。Rocaglamide 可抑制翻译起始因子 eIF4A 的功能。Rocaglamide 还抑制 NF-κB 的活性。Rocaglamide 具有抗肿瘤活性。
S3569 Spermidine Spermidine 是一种天然的多胺,可刺激细胞保护性 macroautophagy/autophagy
S4438 Benzophenone Benzophenone (Diphenyl ketone, Benzoylbenzene) 可滤除UVA和UVB射线,广泛用于各种防晒霜和个人护理产品中。
S4440 2-Phenylacetamide 2-Phenylacetamide 是从具有雌激素活性的 Lepidium apetalum Willd (LA) 的种子中分离出的主要化合物,可在子宫和MCF-7细胞中增加 Estrogen receptorα (ERα)ERβGPR30 的表达。
S4425 Rifamycin S Rifamycin S 是一种quinone和抗 Gram-positive bacteria(包括MRSA) 的抗生素,是一种用于治疗肺结核和麻风病的临床药物。Rifamycin S 可产生 reactive oxygen species (ROS),并抑制微粒体脂质过氧化 microsomal lipid peroxidation
S4436 Pleuromutilin Pleuromutilin (Drosophilin B, Mutilin 14-glycolate) 是新型抗生素的先导化合物,它通过结合细菌的50S核糖体亚基来抑制细菌蛋白质的合成。
S4494 Methionine Methionine (MRX-1024, D-Methionine) 是 GABAA receptor 的激活剂,可调节神经元活性。
S3588 Hexylene glycol Hexylene glycol (HG, 2-Methyl-2,4-pentanediol, MPD) 是一种衍生自丙酮的氧化溶剂,已广泛用于工业化学品和化妆品中。Hexylene glycol 具有抗菌 antibacterial 和抗真菌 antifungal 的特性。
S3595 D-Gluconic acid D-Gluconic acid 是一种抗真菌 antifungal 药。
S6446 Sodium citrate dihydrate Sodium citrate dehydrate (Trisodium citrate dihydrate, Citric acid trisodium salt dihydrate) 是一种首选的抗凝血剂。
S3594 Adipic acid Adipic acid (Hexanedioic acid) 是一种重要的二羧酸,可用于制造尼龙和聚氨酯塑料。
S3596 Polyvinylpyrrolidone Polyvinylpyrrolidone (PVP, Polyvidone, Povidone) 是一种惰性的、水溶性的、无毒的、耐温且pH稳定的、具有生物相容性的、可生物降解的聚合物,有助于封装和满足亲水性和亲脂性药物的需求。Polyvinylpyrrolidone 已被广泛测试并用作有效的伤口愈合促进剂。
S3598 Sucrose Sucrose (D-(+)-Saccharose) 是植物天然产生的一种常见糖,是一种二糖,由两个单糖:葡萄糖和果糖组成的分子。
S4424 Hyaluronidase Hyaluronidase (Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase, Amphadase, Hydase, Vitrase) 是一种天然酶,可降解透明质酸,而透明质酸是细胞外基质的重要组成部分。
S0235 Lavendustin B Lavendustin B 抑制 HIV-1 integrase (IN) 与其同源的细胞辅助因子 lens epithelium-derived growth factor (LEDGF/p75) 的相互作用。Lavendustin B 是 Tyrosine Kinase 的抑制剂,也是 glucose transporter 1 (Glut1) 的竞争性抑制剂。
S9794 Melittin Melittin (MLT, Forapin, Forapine) 是 phospholipase A2 (PLA2) 的活化剂,可刺激低分子量PLA2的活性,但不会增加高分子量酶的活性。
S3168 cis-Resveratrol cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) 是Resveratrol的顺式异构体。Resveratrol 是一种天然的酚类化合物,具有抗氧化、抗炎、保护心脏和抗癌的特性。Resveratrol 是 pregnane X receptor (PXR) 的抑制剂,也是 Nrf2SIRT1 的激活剂,并可能诱导凋亡。Resveratrol 还可抑制多种靶标,包括 5-lipoxygenase (LOX)cyclooxygenase (COX)IKKβDNA polymerases αδ,IC50分别为2.7 μM、<1 μM、1 μM、3.3 μM和5 μM。
S3499 Monocaprylin Monocaprylin (2,3-dihydroxypropyl octanoate, Monoctanoin, 1-Octanoyl-rac-glycerol, MC) 对金黄色葡萄球菌和大肠杆菌具有优异的抗菌活性。
S0921 Wilforine Wilforine (WR) 是在wilfordii植株中发现的倍半萜吡啶生物碱,可显著地抑制 P-glycoprotein (P-gp) 的外排活性。
S3351 Sodium phenylpyruvate Sodium phenylpyruvate (Phenylpyruvic acid sodium salt) 可抑制氨基酸形成 amino acid formation 并降低氧气消耗。
S2995 4-Hydroxyphenylpyruvic acid 4-Hydroxyphenylpyruvic acid (4-HPPA) 是一种丰富的多酚结肠代谢产物,是一种有效的清除剂,可抑制 free radicalscyclooxygenase-2 (COX-2) 的水平,并有助于降低结肠癌发展的风险。
S6918 Oleandrin (PBI-05204) Oleandrin (PBI-05204, Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol) 是 Na+/K+-ATPase 的抑制剂,IC50值为0.62 μM。Oleandrin 可诱导凋亡并减少人胶质瘤细胞的体外迁移。
S6990 Phytohemagglutinin Phytohemagglutinin (PHA, Phaseolus vulgaris agglutinin) 在毕赤酵母中利用天然信号肽或酿酒酵母α-因子前体序列表达,将蛋白质引导至分泌途径。Phytohemagglutinin 可通过增加凋亡蛋白 Bax 和激活 caspases-3 来诱导人HEp-2癌细胞的凋亡。
P1201 LL37 (Human cathelicidin) LL37 (Human cathelicidin, Ropocamptide) 是与Cathelicidin相关的 antimicrobial 抗菌肽,具有强大的趋化和免疫调节特性。
S3069 Deoxycholic acid sodium salt Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) 会特定地激活刺激棕色脂肪组织(BAT)的 TGR5 receptor (GPCR19) 的产热活动。
S3248 2'-Deoxyadenosine 5'-monophosphate 2'-Deoxyadenosine 5'-monophosphate (5'-dAMP) 是一种内源性代谢产物,仅在酸性条件下被光敏降解。
S3268 2'-Deoxycytidine 5'-monophosphate 2'-Deoxycytidine-5'-monophosphoric acid (dCMP) 是一种内源性代谢产物,可以用作描述由二次电子诱导的DNA链断裂机理的模型,并且主要通过C-O磷酸酯键的解离而分解。
S3318 N-Acetyl-L-arginine dihydrate N-Acetyl-L-arginine (Ac-Arg-OH) dihydrate 是一种内源性代谢产物。
S3319 Levoglucosan Levoglucosan (LG, LEV, Leucoglucosan, Glucosan, 1,6-anhydro-b-D-Glucose) 是一种内源性代谢产物。
S3324 Sodium 2-(1H-indol-3-yl)acetate Sodium 2-(1H-indol-3-yl)acetate (3-Indoleacetic acid sodium, Indole-3-acetic acid sodium, 3-IAA sodium) 是一种内源性代谢产物。
S3326 Phytic acid dipotassium salt Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)) 是一种稻谷提取物和消化物中的内源性代谢物,可抑制 β-secretase 1 (BACE1),其IC50值约为0.25 μM。
S3331 2-Aminoethylphosphonic acid 2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) 是一种丰富而普遍存在的天然膦酸酯,被许多原核谱系用作磷源。
S3335 Phospho(enol)pyruvic acid monopotassium salt Phospho(enol)pyruvic acid monopotassium salt (Potassium 1-carboxyvinyl hydrogenphosphate) 是一种内源性代谢产物。
S3343 Methyl β-D-Galactopyranoside Methyl β-D-Galactopyranoside (Methyl beta-D-galactoside, Methylgalactoside) 是一种内源性代谢物。
S3370 3-Methoxytyramine hydrochloride 3-Methoxytyramine (3-O-methyl Dopamine, 3MT) hydrochloride 是多巴胺的主要细胞外代谢产物,是一种神经调节剂,在某些情况下可能参与运动控制。
S3310 D-(+)-Galacturonic acid monohydrate D-(+)-Galacturonic acid monohydrate (D-Galacturonic acid hydrate, d-GalA, D-galUA) 是一种内源性代谢产物,可用于工程酿酒酵母中。
S3323 2-Hydroxycaproic acid 2-Hydroxyhexanoic acid (2-Hydroxyhexanoic acid) 是一种内源性代谢产物。
S2997 DL-Tartaric acid DL-Tartaric Acid (2,3-Dihydroxysuccinic acid) 是一种白色结晶有机酸,可从许多植物中,特别是罗望子树tamarinds和葡萄grapes中分离出来,并用作抗氧化剂和添加剂,以赋予酸味。
S3087 N-Acetyl-DL-methionine N-Acetyl-DL-methionine 是一种活性内源性代谢产物,可降低雄性Bom:NMRI mice的肝脏 glutathione 水平。
S3092 Glyoxylic acid monohydrate Glyoxylic acid monohydrate (2,2-Dihydroxyacetic acid) 是一种与大气有关的酮酸。
S3093 Pyrazole Pyrazole (1H-pyrazole) 是具有两个氮原子的五元杂芳族环,具有重要意义。Pyrazole 是设计和开发新药理学必不可少的支柱。
S3094 N-Acetyl-L-alanine N-Acetyl-L-alanine (NAAL, Ac-Ala-OH) 是一种活性内源性代谢产物。
S3157 3-Hydroxybenzaldehyde 3-Hydroxybenzaldehyde (3-HBA) 是自然界中常见的一种苯甲醛,由 3-hydroxybenzyl-alcohol 脱氢酶产生,并且是大鼠和人体中醛脱氢酶(ALDH)的底物。3-Hydroxybenzaldehyde 具有血管保护作用。
S3315 6-Hydroxyindole 6-Hydroxyindole (1H-indol-6-ol) 是一种内源性的有效且持久的 OATP1B1 的抑制剂,其IC50值约为10 μM。
S3334 Glycolaldehyde dimer Glycolaldehyde dimer (2,5-Dihydroxy-1,4-dioxane, 1,4-Dioxane-2,5-diol, DD) 是一种活性内源性代谢产物,当与甘氨酸(Gly)或硫酸铵(AS)反应时,具有中等吸收性和荧光性。
S3336 Heptadecanoic acid Heptadecanoic acid (C17:0) 是一种奇数链饱和脂肪酸,可显著地抑制细胞增殖和迁移,同时促进PC-9和PC‑9/GR细胞的凋亡。Heptadecanoic acid 与多种疾病相关,包括冠心病,前驱糖尿病和2型糖尿病以及多发性硬化症的发生率。
S3337 L-Histidinol dihydrochloride L-Histidinol dihydrochloride 是必需氨基酸L-组氨酸的结构类似物,是一种 protein biosynthesis 的可逆抑制剂,它引起培养中非致瘤和致瘤细胞的不同反应。
S3338 D-(-)-Lyxose D-(-)-Lyxose (D-Lyxose) 是一种活性内源性代谢产物。
S3345 Nα-Acetyl-L-lysine Nα-Acetyl-L-lysine (Ac-Lys-OH, N(alpha)-Acetyllysine) 是一种活性内源性代谢物。
S3347 3-Methylglutaric acid 3-Methylglutaric acid (MGA, 3MG acid) 是一种明显的C6二羧酸有机酸,可以用作单一的固态NMR标准化合物来执行除磁体匀场之外的所有校准步骤。
S3348 O-Acetyl-L-serine hydrochloride O-Acetyl-L-serine (OAS, O-Acetylserine, O-Acetyl-L-serine) hydrochloride (HCl) 是一种细菌和植物中氨基酸半胱氨酸生物合成的中间体,其显示出一种信号功能,不论植物的硫状态如何,它都能改变特定基因的转录水平。
S3358 4-Acetamidobutyric acid 4-Acetamidobutanoic acid (N-acetyl GABA) 是一种 Gamma-aminobutyric acid (GABA) 的衍生物,由GABA氮原子的单乙酰化产生。
S3360 Bis(2-ethylhexyl) phthalate Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) 可诱导幼虫斑马鱼 Danio rerio 中的 DNA strand breaks 和基因表达改变。
S3095 Itaconic acid Itaconic acid 是一种巨噬细胞特异性 (Mϕ-specific) 代谢产物,可介导巨噬细胞代谢与腹膜肿瘤之间的交互作用。Itaconic acid 还是聚合物,化学品和燃料的前体,可以由许多真菌合成。
S3096 L-Histidine monohydrochloride monohydrate L-Histidine monohydrochloride monohydrate (L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O) 是必需氨基酸L-组氨酸的结构类似物,是 protein biosynthesis 的可逆抑制剂,可引起培养中非致瘤细胞和致瘤细胞的不同反应。
S3098 N-Acetylglycine N-Acetylglycine (NAGly, Aceturic acid, Acetamidoacetic acid) 是许多食品的次要成分,没有遗传毒性或急性毒性。
S3097 5,6-Dimethylbenzimidazole 5,6-Dimethylbenzimidazole (5,6-DMB, Dimezol, Dimedazol, 5,6-Dimethyl-1H-benzo[d]imidazole, 5,6-Dimethyl-1H-benzimidazole) 是一种维生素B12的前体。
S3107 D-Pyroglutamic acid D-Pyroglutamic acid (D-5-Oxoproline, D-Pyr-OH, 5-oxo-D-proline, (R)-5-Oxopyrrolidine-2-carboxylic acid) 是一种有效的内源性代谢产物,可对抗由N-methyl-D-aspartate receptor拮抗剂 AP-5 诱导的被动回避行为的中断。
S3109 N-Acetyl-L-leucine N-acetyl-L-leucine 是一种有效的内源性代谢产物,通过在小脑和丘脑中起作用,加速单侧迷路切除后前庭代偿。
S3111 Pyridoxal hydrochloride Pyridoxal hydrochloride (HQ) 是一种活性内源性代谢产物。
S3365 (S)-(-)-1-Phenylethanol (S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) 是一种具有风味特性的1-Phenylethanol的对映异构体。
S3366 Monoethyl malonic acid Monoethyl malonic acid (Ethyl hydrogen malonate, Monoethyl malonate, 3-Ethoxy-3-oxopropanoic acid) 是 ethyl 3-ethoxypropionate (EEP) 的主要尿代谢产物。
S3320 (R)-3-Hydroxybutanoic acid (R)-3-Hydroxybutanoic acid (R-3HB, D-3-hydroxybutyric acid) 是PHB (poly[(R)-3-hydroxybutyrate])的单体,具有广泛的工业和医学应用。(R)-3-Hydroxybutanoic acid 也可以用作合成纯的可生物降解的PHB及其共聚酯的手性前体。
S3049 Calcium 2-hydroxy-4-(methylthio)butanoate Calcium 2-hydroxy-4-(methylthio)butanoate 是一种活性内源性代谢物。
S3135 2-Amino-1-phenylethanol 2-Amino-1-phenylethanol (2-APE) 是一种去甲肾上腺素类似物。
S3221 Thymidine 5'-monophosphate disodium salt Thymidine-5'-monophosphate (5'-Thymidylic acid) disodium salt 是一种活性内源性代谢物。
S3311 Myosmine Myosmine 是次要的烟草生物碱之一,并存在于各种食品中。Myosmine 对 a4b2 nicotinic acetylcholinergic receptors (nAChR) 具有低亲和力,Ki为3300 nM。
S3321 N-Methylnicotinamide N-Methylnicotinamide (MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide) 是一种活性内源性代谢产物,可通过调节ADMA-DDAH轴改善内皮功能障碍并减轻动脉粥样硬化。
S3325 L-Cysteic acid monohydrate L-Cysteic acid monohydrate (CAM) 是一种活性内源性代谢物。
S3329 (L)-Dehydroascorbic acid (L)-Dehydroascorbic acid (DHA) 是一种l-Ascorbic acid (AsA)的氧化形式,其在硫醇的存在下可有效地清除非热等离子体诱导的羟基自由基,而自身不能清除羟基自由基。
S3342 Petroselinic acid Petroselinic acid (PSA) 是一种从香菜果实的植物油中分离出来的油酸的位置异构体。Petroselinic acid 可用于新槐糖脂的发酵。
S3344 Serotonin creatinine sulfate monohydrate Serotonin (5-Hydroxytryptamine) creatinine sulfate monohydrate 是一种活性内源性代谢产物。
S3346 1-Methylnicotinamide chloride 1-Methylnicotinamide (1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium, Trigonellamide) chloride 是烟酰胺的活性内源性代谢产物,具有抗炎和抗血栓形成的作用。1-Methylnicotinamide 可增强肿瘤血管的形成,并显著地增加 prostacyclin (PGI2) 的生成。
S3349 Phosphocholine chloride calcium salt tetrahydrate Phosphocholine (Phosphorylcholine) chloride calcium salt tetrahydrate 是一种活性内源性代谢物。
S3350 Cholesteryl linoleate Cholesteryl linoleate 是一种人鼻液中极性较低的脂质,助力固有的抗菌活性。
S3352 Tricosanoic acid Tricosanoic acid 是一种脂族羧酸,具有很强的生发作用。
S3353 Lithium acetoacetate Lithium acetoacetate (LiAcAc, Acetoacetic acid lithium salt, Lithium 3-oxobutanoate) 是一种活性内源性代谢产物,可影响细胞系的生长。Lithium acetoacetate 可用作乙酰乙酸盐标准品,用于测量生物样品中的乙酰乙酸。
S3354 DL-2,3-Diaminopropionic acid monohydrochloride DL-2,3-Diaminopropionic acid monohydrochloride (2,3-Diaminopropanoic acid hydrochloride) 是一种活性内源性代谢物。
S3355 3-Hydroxyanthranilic acid 3-Hydroxyanthranilic Acid (3-HAA, 3-HANA)是一种色氨酸代谢物具有免疫调节作用,可能是通过抑制 PI3K/Akt/mTORNF-κB 活性,减少促炎性介质的产生。
S3356 Phosphonoacetic acid Phosphonoacetic acid (PAA) 是一种活性内源性代谢产物,具有限制 DNA biosynthesis 的潜力。Phosphonoacetic acid 具有抗病毒的活性。
S3357 Elaidic acid Elaidic acid 是一种主要的反式脂肪酸,可抑制细胞活力,并通过增强氧化应激 oxidative stress 来促进细胞的凋亡。Elaidic acid 可用作药物溶剂。
S3359 Isomaltulose hydrate Isomaltulose (Palatinose) hydrate 是一种 disaccharide carbohydrate,广泛应用于在运动期间维持血糖和水合作用。
S3361 (3-Carboxypropyl)trimethylammonium chloride (3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine, γBB hydrochloride) 是小鼠饮食中L-carnitine被肠道微生物分解的中间代谢产物。
S3362 D-Gulonic acid γ-lactone D-Gulonic acid γ-lactone (Gulonolactone, D-Gulono-1,4-lactone, 1,4-D-Gulonolactone) 是一种活性内源性代谢物。
S3363 DL-Mandelic acid DL-Mandelic acid (MA, 2-Hydroxy-2-phenylacetic acid, Amygdalic acid, Almond acid) 可通过阴离子交换反应嵌入到Zn-Al层状双氢氧化物(LDH)中,从而构建新型的抗菌分层材料。
S3367 cis-4-Hydroxy-D-proline cis-4-Hydroxy-D-proline (H-D-cis-Hyp-OH) 是一种内源性代谢产物,可用于研究D-丙氨酸脱氢酶的特异性和动力学。
S3368 Uridine-5'-diphosphate disodium salt Uridine-5'-diphosphate (UDP) disodium salt 是一种有效的、选择性的 P2Y6 receptor 的天然激动剂,其EC50值为300 nM,pEC50值为 6.52。Uridine-5'-diphosphate (UDP) disodium salt 也是 P2Y14 receptor 的拮抗剂,pEC50值为 7.28。
S3371 N-Acetyl-D-mannosamine N-Acetyl-D-mannosamine (ManNAc, N-acetyl-beta-mannosamine) 是唾液酸的前体,可改善年龄相关的突触传递和长期增强(LTP)的衰减。N-Acetyl-D-mannosamine 的治疗是认知功能障碍的潜在治疗应用。
S3088 (±)-Methyl Jasmonate (±)-Methyl Jasmonate (MeJA, Methyl jasmonate, Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate),是一种植物激素,在植物中起着至关重要的细胞调节剂的作用,是调节炎症性肠病(IBDs)的新候选药物,可调节 caspase 型蛋白酶家族主要类型的表达。
S3169 2'-Deoxyuridine 5'-monophosphate disodium salt 2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) 是胸苷酸合酶的底物,并可被转化为deoxythymidine monophosphate (dTMP)。在甲基化步骤中,dUMP对dTMP的抑制作用是控制细菌和真核细胞生长的关键。
S3322 Nicotinuric acid Nicotinuric acid (NUA) 是烟酸的主要排毒产物,可以作为烟酸在肝脏生物转化中的简单定量指标。
S3332 D-Mannosamine hydrochloride D-Mannosamine hydrochloride ((2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride) 是一种活性的内源性代谢产物。
S3364 3-Hydroxyphenylacetic acid 3-Hydroxyphenylacetic acid (3-HPAA) 是一种酚酸,主要存在于橄榄油废水中,也是膳食类黄酮槲皮素flavonoid quercetin的肠道代谢产物。3-Hydroxyphenylacetic acid 具有抗菌性能。
S3040 Isocitric acid trisodium salt Isocitric acid (DL-Isocitric acid) trisodium salt 是一种活性的内源性代谢产物。
S3089 12-Hydroxydodecanoic acid 12-Hydroxydodecanoic acid (G12) 是一种活性内源性代谢产物。
S3341 Palmitoleic acid Palmitoleic acid (POA, Palmitoleate) 可通过依赖于PPARα的 AMPKFGF-21 活化来刺激肝脏中葡萄糖的摄取。
S2989 Nα-Acetyl-L-asparagine Nα-Acetyl-L-asparagine (N-Acetylasparagine, (S)-2-acetamido-4-amino-4-oxobutanoic acid) 是一种存在于人脑中的内源性代谢产物。
S2991 Thiamine monophosphate chloride dihydrate Thiamine monophosphate chloride dihydrate (Vitamin B1 Monophosphate Chloride, Sineurina, Phosphothiamine) 是一种内源性代谢物。
S2992 Sodium mesoxalate monohydrate Sodium mesoxalate monohydrate (sodium 2,2-dihydroxymalonate) 是一种内源性代谢产物。
S2993 D-Saccharic acid potassium salt D-Saccharic acid potassium salt (D-Glucaric acid potassium, Potassium bisaccharate) 是一种内源性代谢产物。
S2999 Acetic acid octyl ester Acetic acid octyl ester (Octyl acetate) 是野生 parsnip (Pastinaca sativa) 的外壳或油管中精油的主要成分之一。Acetic acid octyl ester 具有抗氧化活性。
S3006 Methyl isoeugenol Methyl isoeugenol (Methylisoeugenol) 是从 Acori Tatarinowii Rhizoma 分离得到的丁香酚类似物异丁香酚。Methyl isoeugenol 是一种对Z. diversus极具吸引力的诱剂,可作为监控和雄性灭计划中的引诱剂。
S3009 Menthone Menthone 是薄荷精油(Mentha piperita L.)的主要挥发性成分之一。Menthone 可用作抗氧化剂,具有良好的补偿作用,可显着减少精子细胞中的 DNA damages
S3091 Methyl acetoacetate Methyl acetylacetate (MAA, Acetoacetate methyl ester, Methyl 3-oxobutanoate, Methyl 3-oxobutyrate, Methyl acetoacetate, Methyl acetylacetate) 是一种内源性代谢产物,可用作合成药物的化学试剂。
S2998 Isophorone Isophorone (IPHO) 是一种α,β-不饱和环状酮,是一种透明的液体,带有樟脑样的气味。Isophorone 可用作聚合物的前体。
S3313 Nudifloric Acid Nudifloric acid (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid),是从一种抗氧化、抗癌、抗炎、抗糖尿病、抗肥胖、抗血管生成和抗伤害感受活动飞虫草 Cordyceps bassiana 中分离出来的。
S3317 cis-3-Hexenyl hexanoate Cis-3-Hexenyl hexanoate ((Z)-3-hexenyl hexanoate) 是一种植物挥发物,可将热带和果肉风味与柑橘和绿色细腻感带入各种水果风味。
S3327 Disodium 5'-inosinate monohydrate Disodium 5'-inosinate monohydrate (Inosine 5'-monophosphate disodium salt hydrate) 是一种内源性代谢物。
S3333 (2R,3R)-(-)-2,3-Butanediol (2R,3R)-(-)-2,3-Butanediol ((2R,3R)-Butane-2,3-diol) 是内源性代谢产物。
S2990 Dihydroxyfumaric acid hydrate Dihydroxyfumaric acid hydrate (DHF) 是一种内源性代谢物。Dihydroxyfumaric acid hydrate (DHF) 的二酯衍生物已专门用作有机合成中的亲电子试剂。
S2988 DL-5-Hydroxylysine hydrochloride DL-5-Hydroxylysine hydrochloride 是一种内源性代谢产物,是5-羟基赖氨酸D-和L-对映体的外消旋混合物,可用作自由基诱导的蛋白质氧化的潜在靶标。
S2994 DL-Homocysteine DL-Homocysteine 是一种弱神经毒素,会影响脑中 kynurenic acid (KYNA) 的产生。DL-Homocysteine 可抑制KYNA生物合成酶、kynurenine aminotransferases (KATs) I和II的活性。
S3099 δ-Valerolactone δ-Valerolactone (Tetrahydro-2H-pyran-2-one, 5-Valerolactone, oxan-2-one) 是一种内源性代谢物。
S3328 N-Formyl-L-methionine N-Formyl-L-methionine (For-Met-OH) 是一种内源性代谢产物。
S6955 Insulin (human) Insulin (human) (Insulin regular) 是一种调节葡萄糖水平的多肽激素。Insulin 通常用于治疗糖尿病患者的高血糖症。效价(potency):29 units/mg。
S2986 9-Methoxycanthin-6-one 9-Methoxycanthin-6-one 是存在于完整的植物部分和不同外植体的愈伤组织中的具有抗肿瘤活性的成分。
S3108 2,5-Dimethylpyrazine 2,5-Dimethylpyrazine (NSC 49139) 是一种内源性代谢产物。
S2996 L-DAB HBR L-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) 是一种 GABA (Gamma-aminobutyric acid) transaminase 的抑制剂,IC50值大于500 μM。L-DAB HBR 表现出抗肿瘤活性。
S3029 Malonic acid Malonic acid (MOA) 是气溶胶中的主要dicarboxylic acids (DCAs)之一,通过实验和计算得出,它是一种强酸。Malonic acid (MOA) 可充当形成基于SA-A的纯簇的中介桥。
S3086 Maleic acid Maleic acid 可抑制 glutamate decarboxylase (GAD) 的活性,从而增强 Listeria monocytogenes 的酸敏感性。Maleic acid 会影响细胞外 GABA 的水平。
S3090 trans-Aconitic acid trans-Aconitic acid (TAA) 是Echinodorus grandiflorus(一种在巴西用于治疗类风湿性关节炎的药用植物)的叶子中的丰富成分。
S3101 2-Deoxy-D-ribose 2-Deoxy-D-ribose (Thyminose, Deoxyribose) 是一种内源性代谢产物。
S3118 L-Homoserine L-Homoserine (L-Hse) 是苏氨酸,蛋氨酸和赖氨酸的重要生物合成中间体。
S3123 3-Methyl-2-buten-1-ol 3-Methyl-2-buten-1-ol (Prenol, Prenyl alcohol, Dimethylallyl alcohol) 是一种内源性代谢产物。
S3143 Pyruvic acid Pyruvic acid (Acetylformic acid) 是一种重要的有机化学中间体,在心肌细胞的病理生理和治疗中发挥作用。Pyruvic acid 可显着提高 lactate dehydrogenase (LDH)creatine kinase (CK) 的水平,并降低 Ca2+Mg2+-ATPase 和 Na+K+-ATPase 的水平。
S3084 Guanosine 5'-triphosphate trisodium salt Guanosine 5'-triphosphate (5'-GTP, Guanosine triphosphate, H4GTP) trisodium salt 是鼠细胞中成肌细胞分化的增强剂。Guanosine 5'-triphosphate trisodium salt 可上调miRNA(特别是miR133a和miR133b)和肌原性调节因子,并诱导人肌原性前体细胞在细胞外环境中释放出被鸟苷基分子(主要是鸟苷)填充的外泌体。
S3125 N-Formylglycine N-Formylglycine (2-formamidoacetic acid, For-Gly-OH, FGly) 是一种内源性代谢产物。
S3126 Sodium 2-hydroxybutanoate Sodium 2-hydroxybutanoate (Sodium 2-hydroxybutyrate, Sodium DL-2-hydroxybutyrate)是由2-氨基丁酸转化而成的一种中间代谢物。
S3127 2,4-Dihydroxypyrimidine-5-carboxylic acid 2,4-Dihydroxypyrimidine-5-carboxylic Acid (Uracil 5-carboxylic acid, Isoorotic acid, 5-Carboxyuracil) 是一种内源性代谢产物。
S3128 N-Acetyl-D-galactosamine N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) 是一种内源性代谢物。
S3131 L-(-)-Glucose L-Glucose (L-(-)-Glucose) 是D-葡萄糖的对映异构体。L-Glucose 可促进食物摄取,而细胞不能将其用作能量来源,因为它不能被己糖激酶磷酸化。
S3134 D-(-)-Tartaric acid D-(-)-Tartaric acid 是酒石酸的非天然异构体,它是具有广泛的工业和科学应用的重要手性化学构件。
S3141 Maleimide Maleimide 显示出荧光猝灭能力,并且可以作为荧光探针用于硫醇分析物的特异性检测。Maleimide 还用于生产抗体偶联药物(ADC),用于癌症研究。
S3142 Potassium sorbate Potassium sorbate (Sorbic acid potassium) 是一种无毒的食品防腐剂,它是从 Sorbus aucuparia 中分离出来的。Potassium sorbate 是大多数霉菌,酵母菌和某些细菌的有效抑制剂。
S3145 Pimelic acid Pimelic acid (Heptanedioic acid, 1,5-Pentanedicarboxylic acid, 1,7-Heptanedioic acid) 是源自脂肪酸合成途径的枯草芽孢杆菌中生物素的前体。
S3152 Glutaric acid Glutaric acid (GA) 是一种有吸引力的C5二羧酸,在生物化学工业中具有广泛的应用。
S3159 Citraconic acid Citraconic acid (CA) 是一种存在于野生大豆中的甲基支链脂肪酸。
S3316 5-Hydroxy-1-tetralone 5-hydroxy-1-tetralone 是一种荧光标记 fluorescent labeling 的试剂,用于从少量生物样品中测定糖鞘脂。
S3330 Maleamic acid Maleamic acid ((Z)-4-Amino-4-oxobut-2-enoic acid) 是一种内源性代谢产物。
S3339 3-(2-Hydroxyphenyl)propionic acid 3-(2-Hydroxyphenyl)propanoic acid (Melilotic acid, Melilotate, 2-hydroxybenzenepropanoic acid) 是一种内源性代谢产物。
S2987 4-Methyl-2-oxovaleric acid 4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) 是由星形胶质细胞释放至神经元,可以通过氨基转移酶重新形成亮氨酸。4-Methyl-2-oxovaleric acid 可降低骨骼肌中蛋白质的降解速率。4-Methyl-2-oxovaleric acid 可通过抑制 alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) 的活性来发挥 oxidative phosphorylation (OXPHOS) 的解偶联剂和代谢抑制剂的功效。
S3266 L-Anserine nitrate salt L-Anserine nitrate salt 是一种存在于大多数动物组织中的二肽,具有抗氧化、抗交联和抗糖基化的作用。L-Anserine 可防止内质网应激诱导物诱导的神经毒性。
S1273 Amarogentin Amarogentin (AG) 是一种主要从 SwertiaGentiana 根中提取的裂环烯醚苷,具有抗氧化、抗肿瘤和抗糖尿病的作用。Amarogentin 是苦味受体 TAS2R1 的激动剂,可抑制LAD-2细胞中substance P诱导的新合成的 TNF-α 的产生。Amarogentin 通过 G2/M 细胞周期的阻滞和 PI3K/Akt 信号通路诱导人胃癌细胞(SNU-16)的凋亡。Amarogentin (AG) 可与 AMP-activated protein kinase (AMPK) 的α2亚基相互作用,并激活三聚体激酶,其EC50值为277 pM。
S0923 Isoliquiritin apioside Isoliquiritin apioside (ISLA, ILA) 是一种分离自 Glycyrrhizae radix rhizome (GR) 的成分,可显著地降低PMA诱导的 matrix metalloproteinase (MMP) 的活性增加并抑制了PMA-诱导 mitogen-activated protein kinase (MAPK)NF-κB 的活化。Isoliquiritin apioside 在恶性癌细胞和EC中具有抗转移和抗血管生成的能力,并且没有细胞毒性。
S2869 Adamantane Adamantane 是一种无色结晶的、带有类似樟脑气味的化合物,首次获得是从石油中分离出的。Adamantane 可用于治疗 influenza A virus 感染。
S9690 Caerulein (FI-6934) Caerulein (Ceruletide, Cerulein, FI-6934) 是一种 cholecystokinin (CCK) receptor 的激动剂,也是一种安全有效的胆囊代谢药,是小肠和胰腺外分泌的兴奋剂。
S6924 D-Luciferin sodium salt D-Luciferin (D-(-)-Luciferin, Firefly luciferin) sodium salt 是萤光素酶的天然底物,可催化生物发光昆虫产生光。
S3290 Procyanidin B2 Procyanidin B2 (PCB2) 是一种存在于常见食品中的天然类黄酮,具有抗炎、抗氧化和抗癌活性。Procyanidin B2 可激活 PPARγ 并诱导小鼠巨噬细胞M2极化。Procyanidin B2 可显著抑制百草枯在大鼠模型中肺组织中 NLRP3 炎性小体的活化。
S9700 Tapinarof Tapinarof (GSK2894512, Benvitimod, WBI 1001, DHPS, DMVT 505) 是一种 aryl hydrocarbon receptor (AhR) 的天然激动剂,可诱导永生化角质形成细胞(HaCaT)中AhR的核易位,EC50值为0.16 nM。Tapinarof 可以以剂量依赖的方式诱导CD4+ T细胞的凋亡,其IC50值为5.2 μM。
S6919 Brevilin A Brevilin A (6-O-Angeloylplenolina) 是一种从Centipeda minima分离得到的倍半萜内酯,是 STAT3 的选择性抑制剂,可通过阻断JAKs酪氨酸激酶结构域 JH1 来减弱 JAKs 的活性。Brevilin A 可通过线粒体途径和 PI3K/AKT/mTOR 失活来诱导结肠腺癌细胞CT26的凋亡和自噬。
S0924 Pteryxin Pteryxin ((+)-Pteryxin) 是一种在 Apiaceae 伞形科中发现的二氢吡喃香豆素衍生物,也是一种有效的 butyrylcholinesterase (BChE) 的抑制剂,IC50值为12.96 μg/ml。Pteryxin 可抑制LPS诱导的小鼠腹膜巨噬细胞中 nitric oxide 的产生,其IC50值为20 μM。Pteryxin 具有治疗阿尔茨海默氏病 (AD) 的潜力。
S0973 Wilforgine Wilforgine 是 Tripterygium wilfordii Hook. F.中主要的生物活性倍半萜生物碱之一,可在M. separata larvae的肌肉中诱导显微结构和超微结构变化,其发挥作用的位置是肌肉系统中的 calcium receptors or channels
S3254 Plantagoside Plantagoside 是一种从 Plantago asiatica 的种子中分离出的黄烷酮葡糖苷,是一种特异性的、非竞争性的 alpha-mannosidase 的抑制剂,IC50值为5 μM。
S3253 Xylobiose Xylobiose (1,4-β-D-Xylobiose, 1,4-D-Xylobiose) 是由木糖单体形成的二糖,是一种天然的底物,可以被来源于 Selenomonas ruminantium (SXA)的β-D-木糖苷酶/α-L-阿拉伯呋喃糖苷酶水解。
S3252 Xylotriose Xylotriose (1,4-b-D-Xylotriose, 1,4-beta-D-xylotriose) 是一种天然的木寡糖底物,可以被来源于 Selenomonas ruminantium (SXA)的催化有效的β-D-木糖苷酶水解。
S3222 Raspberry ketone glucoside Raspberry ketone glucoside (RKG) 是来源于树莓果实的天然产物,是一种抗氧化剂antioxidant,对黑色素 melanin 的合成具有抑制作用。
S3223 L-Quebrachitol L-Quebrachitol (L-QCT) 是可从许多植物中分离出来的天然产物,促进增殖和细胞DNA合成。L-Quebrachitol 可上调 bone morphogenetic protein-2 (BMP-2)runt-related transcription factor-2 (Runx2)mitogen-activated protein kinase (MAPK) 相关调控基因和 Wnt/β-catenin 信号通路,同时下调 nuclear factor-κB(NF-κB) 配体 (RANKL) 受体激活剂的mRNA水平。
S3226 Dehydroabietic acid Dehydroabietic acid (DAA, DHAA) 是一种天然的二萜树脂酸,衍生自针叶植物(如 PinusPicea)通过抑制 SrcSykTAK1 介导的通路来产生抗炎活性。
S3278 Kaempferol-3-O-neohesperidoside Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) 是一种从Primula latifolia Lapeyr. 和 Primula vulgaris Hudson 的叶提取物中分离出的类黄酮,通过 PI3K - GSK-3 信号通路和 MAPK - PP1 通路来刺激大鼠比目鱼肌中的糖原合成 glycogen synthesis
S3289 Daphnoretin Daphnoretin (Dephnoretin, Thymelol) 是一种从Wikstroemia indica C.A. Mey.中提取的具有生物活性的化合物,是 protein kinase C (PKC) 的激活剂。Daphnoretin 通过调节 Akt 信号通路的活性,来抑制肿瘤细胞的增殖、侵袭和迁移,促进其凋亡。
S3295 Taxifolin 7-rhamnoside Taxifolin 7-rhamnoside (TR, Taxifolin 7-O-rhamnoside, Taxifolin 7-O-α-L-rhamnoside) 是一种从 Hypericum japonicum 中分离出的类黄酮,其具有对抗耐甲氧西林金黄色葡萄球菌 (MRSA).的临床分离株的抗菌活性。
S3224 Cinobufagin Cinobufagin (Cinobufagine) 是 Venenum Bufonis 的活性成分,可抑制肿瘤发展。Cinobufagin 可提高 ATMChk2 并降低 CDC25CCDK1cyclin B。Cinobufagin 抑制 PI3KAKTBcl-2,同时增加裂解的 caspase-9caspase-3 水平。由此诱导细胞周期停滞在G2/M期及凋亡。
S3230 L-Fucitol L-Fucitol (1-Deoxy-D-galactitol) 是一种分离自 Myristica fragrans (Nutmeg) 的半乳糖醇类似物,可抑制大肠杆菌K12的半乳糖醇阳性菌株。
S3233 Emetine hydrochloride Emetine hydrochloride (NSC 33669) 是一种从吐根 ipecac 根部提取的主要生物碱,在临床上被用作催吐和抗原生动物药物,可降低 HIFs (hypoxia-inducible factors; HIF-1α and HIF-2α)PDK1RhoARho-kinases (ROCK1 and ROCK2)BRD4。Emetine hydrochloride 可抑制细胞的自噬,并具有抗疟疾、抗病毒、抗细菌和抗变形虫的作用。
S3236 Mesaconitine Mesaconitine 是Aconiti tuber附子块茎中的附子生物碱之一,通过从细胞外空间流入Ca2+来增加内皮细胞中的[Ca2+]i水平。
S3238 Resibufogenin Resibufogenin (Bufogenin, Recibufogenin) 是huachansu华蟾素中具有抗癌作用的成分,通过上调 receptor-interacting protein kinase 3 (RIP3) 和磷酸化 mixed lineage kinase domain-like protein 的Ser358位点来触发坏死病。Resibufogenin 可通过诱导 reactive oxygen species (ROS) 积累发挥细胞毒性作用。Resibufogenin 可诱导凋亡和 caspase-3caspase-8 活性。Resibufogenin 增加 Bax/Bcl-2 表达,并抑制 cyclin D1cyclin EPI3Kp-AKTp-GSK3ββ-catenin 的蛋白表达。
S3245 Nodakenetin Nodakenetin (NANI) 是从Angelica decursiva中分离出的植物性香豆素,可抑制 α-glucosidasePTP1Brat lens aldose reductase (RLAR)AChEBChEβ-site amyloid precursor protein cleaving enzyme 1 (BACE1)。Nodakenetin 可改变 BaxBcl-2 的蛋白质表达,并促进线粒体凋亡。Nodakenetin 具有抗肿瘤活性。
S3251 Goitrin Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) 是板蓝根 Radix isatidis 的主要成分之一,广泛用于治疗发烧、清热的传统中药。Goitrin 具有抗病毒和抗内毒素活性。
S3262 Scopolin Scopolin 是一种从 Arabidopsis thaliana (Arabidopsis) 中分离的香豆素,它通过激活 SIRT1 介导的信号级联反应来减轻肝脏脂肪变性,SIRT1介导的信号通路是脂质稳态的有效调节剂。
S3267 Kaempferol-3-O-rutinoside Kaempferol-3-O-rutinoside (Nicotiflorin, Nikotoflorin, Kaempferol 3-O-β-rutinoside) 是从 Carthamus tinctorius 中提取的黄酮,可改变受伤神经元的形状和结构,减少凋亡细胞,下调 p-JAK2p-STAT3caspase-3Bax 的表达,并降低Bax免疫反应性,并增加 Bcl-2 蛋白表达和免疫反应性。
S3271 Caudatin Caudatin (Cauldatin),一种来源于 Cynanchum auriculatum (C. auriculatum) 的C-21类固醇激素,可通过触发细胞周期阻滞和凋亡,在体外和体内均有效地抑制人神经胶质瘤的生长。
S3273 Hypericin Hypericin (Hyp, HY) 是一种在 common St. John's Wort (Hypericum species) 中发现的天然物质,具有抗抑郁、抗肿瘤和抗病毒 (人类免疫缺陷病毒HIV和丙型肝炎病毒HCV) 活性。Hypericin 对 MAO (monoaminoxidase)PKC (protein kinase C)dopamine-beta-hydroxylasereverse transcriptasetelomeraseCYP (cytochrome P450)
S3291 Myristicin Myristicin (Myristicine) 是一种在 Myristica fragrans 的种子 Nutmeg 中的萜烯样活性成分,是 monamine oxidase (MAO) 的弱抑制剂和 CYP1A2 的机理抑制剂。
S3296 Hispidulin Hispidulin (Dinatin) 是一种在许多传统中草药中存在的天然活性成分,对癌蛋白激酶 Pim-1 具有抑制活性,其IC50值为2.71 μM。Hispidulin 通过 mitochondrial dysfunction 来诱导凋亡,并可抑制HepG2癌细胞中的 P13k/Akt 的信号通路。Hispidulin 通过激活 AMPK 信号通路发挥抗骨质疏松和骨吸收减弱的作用。
S3300 Desoxyrhaponticin Desoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体,是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂,在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。
S3301 Cynarin Cynarin (Cynarine) 是一种来自artichoke洋蓟的植物化学成分,具有多种药理特性,包括自由基清除、抗氧化剂、抗组氨酸和抗病毒活性。Cynarin 可阻断T细胞受体的 CD28 和抗原呈递细胞的 CD80 之间的相互作用。Cynarin 可触发 Nrf2 的核易位,恢复 glutathione (GSH)reactive oxygen species (ROS) 的平衡,并抑制线粒体去极化。
S3305 Medicagenic acid Medicagenic acid (Castanogenin) 是一种分离自 Herniaria glabra L. 的具有生物活性的三萜类五环糖苷,对 xanthine oxidase、collagenase、elastase 和 tyrosinase 具有低抑制活性。
S3240 Phaseoloidin Phaseoloidin 是一种来自烟草毛状线虫的高纯酸糖苷,有助于植物抵抗鳞翅目草食动物。Phaseoloidin 具有抗补体 anti-complement 的作用。
S3242 Loureirin B Loureirin B (LB, LrB),是从Dracaena cochinchinensis中提取的类黄酮,是 PAI-1 的抑制剂,其IC50值为26.10 μM。Loureirin B 可下调TGF-β1刺激的成纤维细胞中的 p-ERKp-JNK。Loureirin B 主要通过增加Pdx-1、MafA、细胞内ATP水平来促进胰岛素分泌,抑制 KATP 电流,Ca2+ 进入细胞内。
S3246 Picfeltarraenin IB Picfeltarraenin IB 是从 Picriafel-terrae 中分离出的葫芦素糖苷,是 acetylcholinesterase (AChE) 的抑制剂。Picfeltarraenin IB 可用于治疗疱疹感染,癌症和炎症。
S3260 3'-hydroxy Puerarin 3'-hydroxy Puerarin 是从 Puerariae Lobatae Radix 中分离出的异黄酮。
S3264 Atractyloside potassium salt Atractyloside potassium salt (ATR potassium salt) 是一种从 Xanthium sibiricum (Cang'erzi) 果实中分离出的毒性二萜糖苷,是一种有效的、特异性的 mitochondrial ADP/ATP carriers的抑制剂。Atractyloside potassium salt 可抑制大鼠心脏线粒体膜的 chloride channels
S3269 Acetylcorynoline Acetylcorynoline 是衍生自中草药 Corydalis bungeana 的主要生物碱成分,具有抗炎特性。Acetylcorynoline 可能通过降低 egl-1 的表达来抑制细胞凋亡通路,并增加 rpn5 的表达来增强 proteasomes 的活性。
S3270 Genipin 1-O-beta-D-gentiobioside Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) 是从栀子 Gardenia jasminoides Ellis 中分离到的一种生物活性类环烷苷,具有保肝、抗炎、抗氧化和抗血栓形成的功能。
S3275 Senkyunolide I Senkyunolide I (SEI, SENI) 是一种从 Ligusticum chuanxiong 中提取的口服活性化合物,具有止痛、抗偏头痛、神经保护、抗氧化和抗凋亡的活性。Senkyunolide I (SEI, SENI) 可上调 Erk1/2 的磷酸化,并诱导 Nrf2 的核易位,伴随着HO-1和NQO1的表达增强。Senkyunolide I (SEI, SENI) 可提高 Bcl-2/Bax 的比例,并抑制裂化的 caspase 3caspase 9 的表达。
S3297 Hosenkoside A Hosenkoside A 是从 impatiens balsamina 种子中分离出来的一种生物活性的葡糖苷。
S3303 Cyperotundone Cyperotundone (CYT) 是在 Chuanxiong Rhizoma 和 Cyperi Rhizoma (CRCR) 中治疗偏头痛的有效成分。
S3307 Galangin 3-methyl ether Galangin 3-methyl ether (3-O-Methylgalangin, 3-Methylgalangin) 分离自 Lychnophora markgravii 的地上部分,具有很强的抗细菌和抗真菌作用。
S3308 Caftaric acid Caftaric acid (CA, Caffeoyl tartaric acid) 是一种具有抗氧化和抗炎作用的天然产物。
S3276 Hosenkoside K Hosenkoside K 是从 impatiens balsamina 种子中分离出来的一种生物活性的葡糖苷。
S6906 Capric acid Capric acid (DA, Decanoic acid, Decylic acid) 是在椰子油和棕榈油中天然存在的中链甘油三酯的成分,可通过直接抑制 AMPA receptor 来控制癫痫发作。癸酸还是 PPARs 的调节配体。由于其特殊的熔化范围,产品可能是固体、液体或半固体状态。
S6899 Licochalcone D Licochalcone D (Lico D, LCD, LD) 是一种从中草药甘草 Glycyrrhiza inflata 中分离出的类黄酮,具有抗氧化、抗炎和抗癌的特性。Licochalcone D 可抑制LPS信号通路中NF-κB p65的磷酸化。Licochalcone D 可抑制 JAK2EGFRMet (c-Met) 活性,并诱导ROS依赖性的凋亡。Licochalcone D 还可诱导 caspases 的活化和 poly (ADP-ribose) polymerase (PARP) 的裂解。
S3265 9''-Methyl salvianolate B 9''-Methyl salvianolate B (9'-methyllithospermate B, 9'-Methyl lithospermate B, 9'''-Methyl salvianolate B) 是丹参 Radix Salviae Miltiorrhizae 的乙醇提取物中的活性成分。
S6885 Ailanthone Ailanthone (AIL, Δ13-Dehydrochaparrinone) 是一种来自臭椿Ailanthus altissima的天然通过抗肝癌(HCC)成分,可通过降低 cyclinsCDKs 的表达、提高 p21p27 的表达来诱导G0/G1期细胞周期阻滞。Ailanthone 可触发DNA损伤,其特征为 ATM/ATR 通路的激活。Ailanthone 可在Huh7细胞中诱导线粒体介导、涉及 PI3K/AKT 信号通路的细胞凋亡。Ailanthone 也是全长 Androgen Receptor (AR-FL)和组成型活性截断AR剪接变体(AR-Vs, AR1-651)的抑制剂,对应的IC50值分别为69 nM和309 nM。
S0917 Allosecurinin Allosecurinine (Phyllochrysine) 是一种从 M.indicaM.discoidea 分离的具有抗真菌活性的Securinega生物碱。
S0906 6-Methoxydihydroavicine 6-Methoxydihydroavicine (6-Methoxy Dihydrosanguinarine) 是一种从是博落回果实中分离得到的生物碱。
S3288 Absinthin Absinthin (Absynthine) 是一种来自 Artemisia absinthium 的天然三萜内酯,具有抗炎特性。Absinthin (Absynthine) 可显著地增强 matrix metalloproteinase-8 (MMP-8) 的表达,并且是潜在的急性肺损伤(ALI)的候选治疗药物。
S3287 Rosamultin Rosamultin 是一种从 Potentilla anserina L. 分离的19 α-hydroxyursane-type三萜,可抑制 HIV-1 protease。Rosamultin 对H2O2诱导的氧化损伤和细胞凋亡具有保护作用。
S6340 Guanidinoacetic acid Guanidinoacetic acid (Guanidino acetic acid, GAA, Glycocyamine, Guanidinoacetate) 正在作为一种饮食制剂被研究。Guanidinoacetic acid 对体育锻炼的男性和女性均具有潜在的人体工程学益处。
S3220 Trigonelline Trigonelline (Trigenolline) 是一种植物生物碱,是咖啡和葫芦巴的主要成分,具有抗脱粒、抗糖尿病、抗氧化、抗炎和神经保护的作用。 Trigonelline 可抑制FcεRI介导的细胞内信号通路,例如 PLCγ1PI3KAkt 的磷酸化。Trigonelline (Trigenolline) 还可抑制RBL-2H3细胞中 microtubule 的形成。
S3235 Sinapine Sinapine 是一种从十字花科物种的种子中分离出来的生物碱,具有抗氧化、抗肿瘤和放射防护的作用。Sinapine 通过下调 P-glycoprotein 来抑制Caco-2细胞的增殖。
S3261 Myrislignan Myrislignan 是一种分离自Myristica fragrans Houtt的木脂素并具有抗炎活性。Myrislignan 可抑制 interleukin-6 (IL-6)tumour necrosis factor-α (TNF-α)。Myrislignan 剂量依赖性地抑制LPS刺激的巨噬细胞中 inducible NO synthase (iNOS)cyclooxygenase-2 (COX-2) 的表达。Myrislignan 可抑制 NF-κB 信号通路的激活。
S3279 Polyphyllin B (Formosanin C) Polyphyllin B (Formosanin C, FC) 是一种从Paris formosana分离得到的薯蓣皂苷,也是一种具有抗肿瘤活性的免疫调节剂。Polyphyllin B (Formosanin C, FC) 可诱导凋亡。
S3280 Linderene Linderene (Lindenenol) 是从Lindera pulcherrima中分离出来的呋喃倍半萜类,具有抗菌和抗氧化活性。
S3281 Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobioside Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobioside (Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobiosiden, Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside) 是一种Descurainiae Semen的活性成分。
S3298 Caulophylline (N-Methylcytisine) Caulophylline (N-Methylcytisine, Caulophyllin, NMC) 是一种具有抗炎活性的三环喹喔啉生物碱。Caulophylline 可与鱿鱼视神经节的 nicotinic acetylcholine receptors (nAChR) 结合,Kd值为50 nM。Caulophylline 可显著地降低 myeloperoxidase (MPO) 的活性,并通过抑制 IκBIKK 磷酸化来阻断 NF-κB 的活化。
S3302 β,β-dimethyl-acryl-alkannin β,β-dimethyl-acryl-alkannin (AN-I, β,β-Dimethylacrylalkannin) 是一种从 Arnebia nobilis Reichb.f. 的根中分离出来的萘醌,有潜力成为抗衰老成分。
S3304 Stylopine Stylopine ((R,S)-Stylopine, Tetrahydrocoptisine) 可降低LPS刺激引起的 nitric oxide (NO)prostaglandin E2 (PGE2)tumor necrosis factor-alpha (TNF-alpha)interleukin-1beta (IL-1beta)IL-6 的生成,以及 cyclooxygenase-2 (COX-2) 的活性。Stylopine 是 Chelidonium majus L 的叶子的主要成分。
S3306 1,1,1,1-Kestohexaose 1,1,1,1-Kestohexaose 是crested wheatgrass叶中的主要DP 6果聚糖。
S3205 Perillaldehyde Perillaldehyde (Perilladehyde, Perillal, PAE, PA) 是紫苏 Perilla frutescens(一种传统的抗氧化剂)的主要成分,可抑制BaP诱导的 AHR 的活化和 ROS 的产生,抑制 BaP/AHR 介导的 CCL2 chemokine 的释放,并激活 NRF2/HO1 抗氧化剂途径。
S3227 5,7-Dimethoxyflavone 5,7-Dimethoxyflavone (5,7-DMF) 是一种 cytochrome P450 (CYP) 3As 的抑制剂,可显著地降低肝脏中CYP3A11和CYP3A25的表达。5,7-Dimethoxyflavone (5,7-DMF) 也是一种有效的 Breast Cancer Resistance Protein (BCRP, ABCG2) 的抑制剂。5,7-Dimethoxyflavone (5,7-DMF) 是Kaempferia parviflora的主要成分之一,具有抗肥胖、抗炎和抗肿瘤作用。
S3237 Deoxyaconitine 3-Deoxyaconitine 是一种从 Aconitum Carmichaeli Debx 的根中分离出来的二萜类生物碱。
S3241 Loureirin A Loureirin A 是一种黄酮类化合物,从被称为龙血的来源于Dracaena cochinchinensis的红色树脂中提取出来。Loureirin A 可通过破坏 PI3K/Akt 信号传导来抑制血小板platelet活化。Loureirin A 可抑制 Akt 磷酸化。
S3247 Icariside I Icariside I (Icarisid I) 是 Epimedii Folium 的主要成分之一,可显着刺激细胞增殖和成骨细胞分化。
S3249 Corypalmine Corypalmine ((R)-(+)-Corypalmine),一种从 Stephania cepharantha 分离的生物碱,是 prolyl endopeptidase/oligopeptidase (PREP/POP) 的抑制剂,IC50值为128.0 μM。
S3255 Pectolinarigenin Pectolinarigenin 是 Cirsium chanroenicum 中的一种抗炎活性成分,是 cyclooxygenase-2 (COX-2)5-lipoxygenase (5-LOX) 的双效抑制剂。
S3256 Tectochrysin Tectochrysin (Techtochrysin, NSC 80687) 是Alpinia oxyphylla Miquel的主要类黄酮之一。Tectochrysin 可显著地增加DR3DR4Fas的表达,并抑制 NF-κB 的活性。Tectochrysin 可诱导细胞凋亡。
S3257 Rebaudioside B Rebaudioside B (Reb B) 是一种从甜叶菊 Stevia rebaudiana 分离的次要甜菊醇糖苷(SGs)之一,并且比许多主要SG具有更好的口感品质。
S3259 Rebaudioside D Rebaudioside D (Reb D) 是在甜叶菊 Stevia rebaudiana (Bertoni) 的叶子中发现的几种糖苷(SGs)之一,这种糖已被鉴定为潜在的甜味剂。
S3272 Steviol (Hydroxydehydrostevic acid) Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902) 是甜味化合物甜菊糖的主要代谢产物,可抑制 CFTR 的活性,降低 AQP2 的表达并促进AQP2降解。
S3274 Glucosyl-vitexin Glucosyl-vitexin (Glucosylvitexin) 是小米中主要的C-糖基黄酮,可抑制 thyroid peroxidase (TPO) 的活性。
S3282 Rebaudioside M Rebaudioside M 是一种从甜叶菊Stevia rebaudiana Bertoni中分离的天然无热量潜在甜味剂,可应用于食品和饮料产品。
S3283 Marmesin Marmesin (S-(+)-Marmesin, (+)-Marmesin, (S)-Marmesin) 是一种具有 COX-25-LOX 双重抑制作用的天然香豆素。
S3284 Tracheloside Tracheloside 是一种从 Carthamus tinctorius 的种子中分离得到的木脂素糖苷,具有抗雌激素作用。Tracheloside 可显著地降低 alkaline phosphatase (AP)(一种雌激素诱导性标记酶) 的活性,IC50为 0.31 μg/ ml。Tracheloside 通过刺激 ERK1/2 来促进角质形成细胞的增殖。
S3285 Dihydrolycorine Dihydrolycorine 是lycorine的衍生物,它是从 Lycoris radiata 草药中分离出来的生物碱。Dihydrolycorine 可阻断腹水细胞中的蛋白质合成并在体内稳定HeLa细胞多核糖体。Dihydrolycorine 具有降压和神经保护的作用。
S3299 Demethyleneberberine Demethyleneberberine (DMB) 是黄柏Cortex Phellodendri Chinensis (CPC) 的成分,可显著地缓解体重减轻并降低 myeloperoxidase (MPO) 活性,同时显著地减少促炎细胞因子的生成,例如 interleukin (IL)-6tumor necrosis factor-α (TNF-α),并抑制 NF-κB 信号通路的激活。Demethyleneberberine (DMB) 可以通过激活 AMPK 途径改善NAFLD (非酒精性脂肪肝疾病)。
S0553 Butyl isobutyl phthalate  Butyl isobutyl phthalate (BIP) 是一种从 Laminaria japonica 的根状茎中分离出来的,α-glucosidase 的非竞争性抑制剂,其IC50值为38 μM。Butyl isobutyl phthalate 具有显著的降血糖作用和治疗糖尿病的潜力。
S3206 5a-Pregnane-3,20-dione 5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) 是一种内源性的孕酮代谢物。5a-Pregnane-3,20-dione 可使肌动蛋白actin解聚,并降低 actinvinculin 的表达。5a-Pregnane-3,20-dione 可通过影响粘附和细胞骨架分子来参与促进乳腺瘤形成和转移。
S2440 Vindesine sulfate Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS) 是一种提取自 Catharanthus roseus的长春花生物碱,是一种有效的有丝分裂 mitosis 的抑制剂,并具有抗肿瘤的活性。Vindesine 与有丝分裂纺锤体的微管蛋白结合,可导致微管结晶和有丝分裂阻滞或细胞死亡。
S0949 Cucurbitacin IIb Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) 可抑制 STAT3JNKErk1/2 的磷酸化,而增强 IκBNF-κB 的磷酸化,阻止 NF-κB 的核易位并降低 IκBαTNF-α 的mRNA表达水平。Cucurbitacin IIb 是从Hemsleya amabilis 中分离出来的,具有抗炎活性并可诱导凋亡。
S6852 Gossypol Gossypol (BL 193) 是一种从棉籽和根中分离出来的口服活性的多酚。Gossypol 是一种 5α-reductase 13α-hydroxysteroid dehydrogenase 的有效抑制剂,在无细胞试验中,对应的IC50值分别为3.33 μM和0.52 μM。Gossypol 还可抑制BH3肽与Bcl蛋白的结合,对 Bcl-XLBcl-2 的IC50值分别为0.4 μM和10 μM。Gossypol 在各种癌细胞中可诱导凋亡和细胞的生长抑制。
S3210 3'-Hydroxy-4'-methoxyacetophenone 3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) 是一种具有消炎潜能的活性多刺疟原虫提取物。
S3213 Veratryl alcohol Veratryl alcohol (VA, Veratrole alcohol, 3,4-Dimethoxybenzyl alcohol) 是一种木质素降解真菌的次生代谢产物,是木质素过氧化物酶 Lignin peroxidase (LiP) 的天然底物。
S3214 Veratraldehyde (3,4-Dimethoxybenzaldehyde) Veratraldehyde (3,4-dimethoxybenzaldehyde, VD, VAD, VAld, Verapamil Related Compound E, Methylvanillin) 是一种香兰素的衍生物,是从薄荷,生姜,波旁香草和树莓等水果中发现并分离出来的化学物质。Veratraldehyde 由于其令人愉悦的木质香气而被广泛用作调味剂和增香剂。Veratraldehyde 还可用作氧化还原循环剂。
S3215 2-O-α-D-Glucopyranosyl-L-ascorbic acid 2-O-α-D-Glucopyranosyl-l-ascorbic acid (AA-2G),是抗坏血酸ascorbic acid (AA)的葡糖苷衍生物,在酶水解为抗坏血酸ascorbic acid后显示出维生素C的活性。AA-2G的抗肿瘤活性是由AA-2G快速水解释放的AA产生的ROS引起的。
S3203 D-Alanine D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) 是一种 glycine site of the N-methyl-d-aspartate (NMDA) receptor 的内源性激动剂。
S3293 Gardenoside Gardenoside 是一种从Gardenia栀子属果实中提取的天然化合物,具有保肝作用。Gardenoside 可抑制 TNF-αIL-1βIL-6NFκB 的活化。Gardenoside 还对游离脂肪酸(FFA)诱导的细胞脂肪变性具有抑制作用。Gardenoside 可通过调节 P2X3P2X7 受体来减轻慢性压迫性损伤大鼠的疼痛。
S3292 Falcarindiol Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) 是一种天然的聚乙炔化合物,存在于伞形科的许多植物中。Falcarindiol 可抑制LPS刺激的 inducible nitric oxide synthase (iNOS)tumor necrosis factor alpha (TNFα)interleukin-6 (IL-6)interleukin-1 beta (IL-1β) 的表达。Falcarindiol 可减弱LPS诱导的 JNKERKSTAT1STAT3 信号分子的激活。
S3263 Agarotetrol Agarotetrol 是一种在沉香树的水提取物中高浓度的酮衍生物。Agarotetrol 可通过加热产生LAC而有助于沉香木的香味。
S3216 Uridine 5'-diphosphoglucose disodium salt Uridine-5'-diphosphoglucose (UDPG, UDP-Glc, UDP-D-Glucose, UDP-α-D-Glucose) 可激活神经免疫系统GPCR P2Y(14) receptor。Uridine-5'-diphosphoglucose 是动物组织和某些微生物中含葡萄糖的寡糖,多糖,糖蛋白和糖脂的前体。
S3250 Veratrine Veratridine (Cevadine, Cevadin, Cevadene)是一种在百合科植物中发现的甾体生物碱,是 voltage-gated sodium channel 活化剂。Veratridine 会在大鼠中诱发类似焦虑的行为。
S7904 2',3'-cGAMP Sodium Salt 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium)是响应哺乳动物细胞质中的DNA产生的,并能以高亲和力结合 STING,且有效地诱导 interferon-β (IFNβ)。2',3'-cGAMP 结合 STING 的Kd值为3.79 nM。
S6630 Dimethylcurcumin (ASC-J9) Dimethylcurcumin (ASC-J9, Dimethyl curcumin, GO-Y025)是一种 androgen receptor (AR) 降解促进剂,可通过降解全长和剪接变异体的雄激素受体来抑制去势抵抗性前列腺癌的生长。
S2766 Glycerol Glycerol (Glycerin)是一种透明,无色和粘稠的液体,可用作润肤剂,溶剂或甜味剂。Glycerol 可改变了聚丙烯酰胺核蛋白凝胶的分离特性。
S8587 Withaferin A Withaferin A (WA, WFA)可通过对硫代烷基化敏感的氧化还原机制阻止肿瘤坏死因子诱导的IκB激酶β的激活,从而有效地抑制 NF-κB 激活。Withaferin A 可与中间丝状体蛋白(IF) vimentin 结合,并具有抗肿瘤和抗血管生成活性。Withaferin A 是一种从 Withania somnifera 分离的甾体内酯。
S2653 9-amino-CPT (9-Aminocamptothecin) 9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin)是一种 Topoisomerase I 抑制剂并具有有效的抗癌活性。9-amino-CPT (9-Aminocamptothecin) 是喜树碱的一种具有活性的、不溶于水的衍生物。
S8620 6-Diazo-5-oxo-L-norleucine 6-Diazo-5-oxo-L-norleucine (Diazooxonorleucine, L-6-Diazo-5-oxonorleucine, DON)是一种从链霉菌中分离出来的抗生素,一种 glutaminase 的拮抗剂对cKGA(肾脏型谷氨酰胺酶)的IC50值约为1 mM。6-Diazo-5-oxo-L-norleucine 具有止痛,抗菌,抗病毒和抗癌的特性。
S2654 Neoruscogenin Neoruscogenin 是从 R. rhizoma 中分离的天然皂苷元。Neoruscogenin 是一种有效且高亲和力的 RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1) 的激动剂。
S8970 HQNO HQNO (2-heptyl-4-hydroxyquinoline-N-oxide)是一种由 P. aeruginosa 分泌的天然喹诺酮。HQNO 也是一种 electron transport chain 的有效抑制剂,其对呼吸链的泛醇-亚铁色素c氧化还原酶区段(Complex III)的Kd值为64 nM。在50 μM menadione存在下,HQNO 还是细菌和线粒体的 Type II NADH : quinone oxidoreductase (NDH-2) 的抑制剂,在50 μM menadione存在的条件下,其IC50值为7.3 μM。
S7895 Thapsigargin Thapsigargin 是一种有效的、非竞争性的 the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) 的抑制剂,对carbachol诱导的[Ca2+]i瞬变在存不存在KCl预刺激条件下的IC50值分别为0.353 nM和0.448 nM。Thapsigargin 可诱导细胞凋亡。Thapsigargin 提取自植物Thapsia garganica
S7905 3',3'-cGAMP 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP)可激活内质网(ER)内源性受体 stimulator of interferon genes (STING) ,从而诱导抗病毒状态和I型IFN的分泌。
S7821 Bufalin Bufalin (BF)是 类固醇受体共激活剂 SRC-3、SRC-1Na+/K+-ATPase 的有效抑制剂。Bufalin 可与Na+/K+-ATPase的亚基α1、α2和α3结合,其Kd值分别为42.5 nM、45 nM和40 nM。Bufalin 是一种从中药蟾酥中分离出来的,具有抗癌活性的,类地高辛免疫反应的主要成分。
S7862 Rottlerin Rottlerin (Mallotoxin, NSC 56346, NSC 94525)是一种从 Mallotus Philippinensis 纯化出来的天然化合物,一种特效的 Protein kinase 的抑制剂,对PKCδ(来自杆状病毒感染的Sf9昆虫细胞)、PKCδ(来自猪脾)和CaM kinase III的IC50值分别为3 μM、6 μM和5.3 μM。Rottlerin 还可以抑制PKCα、PKCγ、PKCβ、PKCη、CKII和PKA,其IC50值分别为30 μM、40 μM、42 μM、82 μM、30 μM和78 μM。
S2447 Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) 是一种有效的微管蛋白聚合抑制剂,IC50为3.4 μM。
S6790 Ellipticine hydrochloride Ellipticine Hydrochloride (NSC 71795, PZE)是一种有效的 DNA topoisomerase II 的抑制剂,并通过其与 cytochromes P450 (CYP)peroxidases 的氧化作用介导形成共价DNA加合物。Ellipticine Hydrochloride 是从澳大利亚的夹竹桃科常绿乔木中分离出来的具有抗肿瘤活性的天然产物。
S8964 Actinomycin D (Dactinomycin) Actinomycin D (Dactinomycin, Act D, RASP-101)是一种从链霉菌属的土壤细菌中分离出来的重要的多肽抗生素。Actinomycin D (Dactinomycin) 可抑制 DNA repair,并使 cell cycle 停滞在G1期,其IC50值分别为0.42 μM和0.4 nM。Actinomycin D (Dactinomycin) 是 autophagy 的激活剂,可在高危慢性淋巴细胞性白血病中诱导p53依赖性细胞的死亡并延长生存期。
S2288 Rubitecan Rubitecan (9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000) 是一种 拓扑异构酶I topoisomerase I 的抑制剂,从中国喜树的树皮和叶子中提取。Rubitecan 也是一种具有抗肿瘤活性的口服喜树碱。
S2009 Indirubin-3'-monoxime Indirubin-3'-monoxime (Indirubin-3'-oxime)是一种选择性的CDK抑制剂,对CDK1-cyclinB, CDK2-cyclinA, CDK2-cyclinE, CDK4-cyclinD1, CDK5-p35的IC50分别为 0.18 μM, 0.44 μM, 0.25 μM, 3.33 μM, 0.065 μM。Indirubin-3'-monoxime是一种直接、选择性的5-lipoxygenase抑制剂,IC50为7.8-10 µM。
S1031 3-Hydroxybutyric acid 3-Hydroxybutyric acid (3-hydroxybutanoic acid, β-Hydroxybutyric acid, BHB)是一种在I型糖尿病中升高的小分子代谢产物。
S2342 Phloretin (RJC 02792) Phloretin (RJC 02792, NSC 407292, Dihydronaringenin)是一种二氢查尔酮,含有多元酚。
S9440 Naringenin chalcone Naringenin chalcone (Chalconaringenin, Isosalipurpol, trans-2'4'6'4-tetrahydroxychalcone) is the main active component of tomato skin extract, has been proposed as an antioxidant, an anti-inflammatory, and a regulator of fat and sex hormone metabolism.
S2325 Morin Hydrate Morin hydrate (Aurantica) 是一种化学化合物,用来检测溶液中的铝或锡的存在,因为Morin hydrate与铝或锡可以形成特有的荧光配位络合物。
S6670 GPNA (L-γ-Glutamyl-p-nitroanilide) GPNA (L-γ-Glutamyl-p-nitroanilide)是一种有效的谷氨酰胺 (Gln) 转运蛋白ASCT2(SLC1A5) 的选择性抑制剂,Ki为55 µM。
S2210 Sphingosine 鞘氨醇,Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine),是具有不饱和烃链的18个碳原子的氨基醇,它形成鞘脂的主要部分,鞘脂是一类细胞膜脂质,其中包括鞘磷脂,一种重要的磷脂。
S6674 Cytosporone B Cytosporone B是天然存在的核孤儿受体Nur77(NR4A1) 激动剂,EC50为0.278 nM。
S6474 3,5-diiodo-L-thyronine (3,5-T2) 3,5-diiodo-L-thyronine (3,5-T2, NSC 90469)是甲状腺激素的内源性代谢产物。 3,5-Diiodo-l-thyronine是治疗肥胖和肝脏脂肪变性的潜在降血脂药。
S9218 Phytolaccagenin Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phtolaccae.
S6653 Nigericin (NSC 292567) sodium salt Nigericin (NSC 292567) sodium salt是从Streptomyces hygroscopicus衍生的抗生素,通过充当H+,K+和Pb2+的离子载体起作用。Nigericin可以激活NLRP3炎性体以诱导促炎和免疫刺激过程。
S3911 Veratramine Veratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.
S9403 Ecliptasaponin A Ecliptasaponin A, a natural triterpenoid glucoside, has protective effects against the pulmonary fibrosis induced by bleomycin via reducing the oxidative stress, lung tissue inflammation, and the subsequent epithelial-mesenchymal transition.
S3928 Baccatin Ⅲ Baccatin Ⅲ is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It exhibits immunomodulatory and anticancer chemotherapeutic activities.
S4938 Cedrol Cedrol是一种天然存在的倍半萜烯醇,是有效的、竞争性的抑制剂,抑制CYP2B6介导的安非他酮羟化酶(bupropion hydroxylase),Ki值为0.9 μM。它还能抑制CYP3A4介导的咪达唑仑羟基化,Ki为3.4 μM。对CYP2C8, CYP2C9和CYP2C19的活性仅有微弱的抑制作用。
S3942 Cardamonin Cardamonin (Alpinetin chalcone)天然存在于良姜属物种的果实中,具有抗炎和抗肿瘤活性。它是一种新型的hTRPA1离子通道拮抗剂,IC50为454 nM,而不与TRPV1和TRPV4相互作用。
S3756 Methyl salicylate Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.
S3763 Cinnamaldehyde Cinnamaldehyde is a flavonoid that is naturally synthesized by the shikimate pathway. Its supplementation can improve glucose and lipid homeostasis in diabetic animals; a TRPA1 agonist.
S3605 Borneol Borneol是一种分离自药用植物如艾纳香、芳味冰片香木的双环类单萜化合物。它是TRPM8的激动剂,能够增加眼部表面湿润。
S4787 Methyl syringate Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
S3867 (E)-Cardamonin (E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.
S4714 (-)-Menthol (-)-Menthol (L-Menthol, Levomenthol, Menthomenthol, Menthacamphor) 是薄荷醇的左旋异构体,常被用作冷却剂,可激活TRPM8。
S2332 Neohesperidin Neohesperidin (NSC 31048) 是一种抗氧化剂,在1,1-diphenyl-2-picryldydrazyl(DPPH)自由基清除测定中,IC50为22.31 μg/ml。
S5755 Methyl Eugenol Methyl eugenol (4-allylveratrole, eugenyl methyl ether, O-methyleugenol), as a constituent in leaves, fruits, stems, and/or roots, is used as a flavoring agent, as a fragrance and as an anesthetic in rodents.
S2935 Nicotinamide Riboside Chloride Nicotinamide Riboside Chloride是烟酰胺核糖(NR)的氯化物盐形式。NR是维生素B3的衍生物,可作为作为NADNAD+的前体。
S3607 Sarsasapogenin Sarsasapogenin (SAR, Parigenin)是一种甾体皂甙元,能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κBMAPK的激活,在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。
S2425 Apocynin (NSC 2146) Apocynin (NSC 2146, Acetovanillone, NSC 209524)是一种选择性NADPH氧化酶抑制剂,IC50 为10 μM.
S9332 (+)-Dipentene (+)-Dipentene, occurring commonly in nature as the fragrance of oranges, is a flavoring agent in food manufacturing.
S5578 Cadaverine Cadaverine is a foul-smelling diamine formed by bacterial decarboxylation of lysine that occurs during protein hydrolysis during putrefaction of animal tissue.
S5140 Cinene Cinene (Limonene, Dipentene) is a clear, colorless liquid hydrocarbon classified as a cyclic monoterpene, and is the major component in oil of citrus fruit peels. It is usually used to make fragrances and flavors.
S5408 Isoprene Isoprene, also called 2-methyl-1,3-butadiene, is usually used as a chemical raw materia.
S6206 1-Butanol 1-Butanol是糖类和其他碳水化合物发酵的次要产物,存在于许多食物和饮料中。
S6019 2-Phenylphenol 2-Phenylphenol,在柠檬中发现,是一种抗真菌剂和防腐剂,用于食品调味剂中。
S5429 Diallyl sulfide Diallyl sulfide, a thioether found naturally in garlic, is a selective inhibitor and also a substrate of CYP2E1 with an IC50 of 17.3 μM. It has protective effects against alcohol- and acetaminophen-induced hepatotoxicity in many studies.
S6751 Brevianamide F Brevianamide F, belonging to a class of naturally occurring 2,5-diketopiperazines, is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by the fungi A.fumigates and Aspergillus sp..
S6359 Purine Purine是一种杂环芳香有机化合物,在DNA和RNA中均发挥关键作用。它还是很多生物分子,如ATP、GTP、cAMP、NADH和辅酶A的重要组成成分。
S2353 Sapogenins Glycosides Sapogenins glycosides (Saponins)是糖苷配基或非糖类,属于天然产品Saponins部分家族。
S3627 Tryptamine Tryptamine是一种单胺生物碱,可能作为神经调节剂和神经递质发挥作用。它是hTAAR1的激动剂,还是非选择性的serotonin receptor激动剂和羟色胺-去甲肾上腺素-多巴胺释放剂(SNDRA)。
S5153 Tetrahydroberberine Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.
S3823 Schizandrol A Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain.
S5642 Homovanillic acid Homovanillic acid (Vanillacetic acid) is a major catecholamine metabolite that is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain.
S9087 Tenuifolin Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.
S2367 Tetrahydropapaverine HCl Tetrahydropapaverine (Norlaudanosine) 是TIQs的一种,是Salsolinol 和 Tetrahydropapaveroline的类似物,对多巴胺神经元具有神经毒性作用。
S3937 Pterostilbene Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes.
S6428 Wilforlide A Wilforlide A是雷公藤多甙中的活性化合物,是用于治疗自身免疫疾病的传统中药。
S5850 Vasicine Vasicine,可分离自A. vasica,是一种生物碱。它是天然的cholinesterase(胆碱酯酶)抑制剂,在临床前模型中具有抗胆碱酯酶活性,可用于阿尔茨海默病的治疗药物开发。
S7956 Brusatol Brusatol (NSC 172924),可分离自B. javanica果实,是一种NRF2抑制剂。
S3781 Ginkgolide C Ginkgolide C (BN-52022), isolated from Ginkgo biloba leaves, is a flavone reported to have multiple biological functions, from decreased platelet aggregation to ameliorating Alzheimer disease. It is an activator of MMP-9.
S9513 Senkyunolide A Senkyunolide A is one of the major bioactive ingredients in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments.
S6049 (+)-(S)-Carvone (+)-(S)-Carvone是一种主要存在于香菜和莳萝种子油中的单萜,用于化妆品、食品和药品制备中。
S6700 Castor oil Castor oil is a popular natural treatment for various common conditions and often used in natural beauty products.
S3830 Protodioscin Protodioscin (Furostanol I), a steroidal saponin compound found in a number of plant species, is able to stimulate testosterone production and it also has an androgen-mimetic action, binding and activating the testosterone receptors.
S8870 Epibrassinolide Epibrassinolide是一种可从多种植物中分离而来的油菜素类固醇,减少毒性,在植物应激反应下刺激其健康生长。
S6701 Corn Oil Corn oil 是一种精制的植物油,常用于脂溶性物质的载体。
S9326 Scopolamine Scopolamine (Skopolamin) is a tropane alkaloid derived from plants of the nightshade family, specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties.
S3860 Allicin Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.
S6493 n-Butylidenephthalide n-Butylidenephthalide ((Z)-Butylidenephthalide, 3-Butylidenephthalide, Butylidenephthalide) 可从当归的氯仿提取物中分离出来,它具有多种生物活性,如减少心绞痛、血小板聚集、增殖、非特异性痉挛。
S6601 (±)-Equol (±)-Equol是大豆异黄酮、黄豆苷和黄豆苷元的一种代谢物。
S3687 Urea Urea (Carbonyldiamide, Ureophil) 是一种溶解度高的有机化合物,源自肝脏中由氨基酸脱氨基作用形成的氨。它是蛋白质分解代谢中的主要最终产物。
S3839 1-Deoxynojirimycin 1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
S3190 N6-methyladenosine (m6A) N6-methyladenosine (m6A, NSC-29409, 6-Methyladenosine, N-Methyladenosine) 是碱基修饰的腺苷类似物,在天然RNAs中作为稀有核苷。N6-methyladenosine(m6A)是mRNA的第五种碱基。
S2370 Ursolic Acid Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol)是一种五环三萜酸,在化妆品中使用。
S6426 Hesperidin methylchalcone Hesperidin methylchalcone源于柑橘,具有强效的抗氧化活性。
S3821 Nuciferine Nuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities.
S9227 Sinensetin Sinensetin (Pedalitin Permethyl ether), a natural polymethoxylated flavone, has potent antiangiogenesis activity.
S3973 L-SelenoMethionine L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.
S2324 Sodium Monensin (NSC 343257) Sodium Monensin (NSC 343257)从 Streptomyces cinnamonensis中分离的, 是一种众所周知的天然的聚醚 类离子载体抗生素的代表。
S2348 Rotenone (Barbasco) Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) 是一种植物杀虫剂,是线粒体电子传递mitochondrial electron transport的抑制剂。Rotenone 可抑制 NADH/DB oxidoreductaseNADH oxidase,对应的IC50值分别为28.8 nM和5.1 nM。Rotenone 可通过增强线粒体活性氧的产生来诱导凋亡。
S2265 Artesunate (WR-256283) Artesunate (WR-256283) 是一种抗疟类药,作用于小细胞肺癌细胞系H69,IC50为< 5 μM。它是一种潜在的STAT3抑制剂,在体外对癌细胞有选择性细胞毒性作用;是有效的EXP1抑制剂。
S6176 Scyllo-Inositol Scyllo-Inositol (Scyllitol, Cocositol, Quercinitol, AZD 103, Scyllo-Cyclohexanehexol)是一种天然存在的植物糖醇,在椰树中含量最为丰富。
S6292 (S)-2-Hydroxysuccinic acid (S)-2-Hydroxysuccinic acid (L-Malic acid)是天然存在的苹果酸同分异构体,主要于酸性和未成熟的水果中被发现。
S6346 L-(+)-Arabinose L-(+)-Arabinose (DL-Arabinose, Pectinose) 是一种用于鉴定、区分戊糖异构酶的底物。
S6061 DL-m-Tyrosine DL-m-Tyrosine是一种有效的、广谱的植物毒素,从某些细叶羊茅的根部流出。
S6163 Traumatic acid Traumatic acid (Trans-2-dodecenedioic acid)是一种植物激素,首次于损伤的绿豆中分离。它是一种有效的伤口愈合剂,是前列腺素合成的中间物。
S6264 Rutin hydrate Rutin (Quercetin-3-O-rutinoside, Rutoside, Sophorin) 是在多种植物如柑橘中所发现的一种配糖。
S6112 Oxalacetic acid Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid)是三羧酸循环的中间物,它与乙酰辅酶A经柠檬酸合酶催化反应生成柠檬酸盐。它还参与糖原异生、尿素循环、乙醛酸循环、氨基酸合成和脂肪酸合成等过程。Oxaloacetate是Complex II的抑制剂。
S6221 Methyl cinnamate Methyl cinnamate 是花椒(Zanthoxylum armatum)的活性成分,是一种广泛使用的具有抗菌和 tyrosinase 抑制剂活性的天然香料化合物。Methyl cinnamate 通过激活3T3-L1前脂肪细胞中的 CaMKK2--AMPK 信号通路来抑制脂肪细胞分化。
S6008 p-Hydroxybenzaldehyde p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol),存在于兰花Gastrodia elataGaleola faberi和香草中,是一种羟基苯甲醛,可与NAD+和H20反应生成4-hydroxybenzoate、NADH和两质子。
S6011 Acetamide Acetamide (ethanamide, Acetic acid amide) 是一种有机化合物,可被用作塑化剂和工业溶剂。
S6018 2,3,4-Trihydroxybenzoic acid 2,3,4-Trihydroxybenzoic acid是转筋草中的酚组分,具有抗氧化活性。
S6043 3-Indoleacetonitrile 3-Indoleacetonitrile是一种植物生长激素,是光照诱导的生长素抑制性激素。
S6045 L-Arabinitol L-Arabinitol (L-lyxitol)是一种糖醇,存在于所有生物中。在很多食物如甘薯、鹿果、乌头叶菜豆和欧洲栗中都有发现。
S6047 Lactose Lactose是一种天然存在于奶及乳制品中的二糖。
S6071 3,5-Dimethoxyphenol 3,5-Dimethoxyphenol (Phloroglucinol dimethyl ether)是一种发现于红豆杉叶中的毒素代谢物。
S6076 Phenylacetylglutamine Phenylacetylglutamine is a product formed by the conjugation of phenylacetate and glutamine. It is a normal constituent of human urine, but other mammals such as the dog, cat, rat, monkey, sheep, and horse do not excrete this compound.
S9564 p-Hydroxy-cinnamic Acid p-Hydroxy-cinnamic Acid在体外具有抗疟活性和体内抗骨质疏松活性。
S2254 4-Demethylepipodophyllotoxin(NSC-122819,VM-26) 4-Demethylepipodophyllotoxin (NSC-122819, VM-26, DMEP) is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly.
S2442 Inosine Inosine (NSC 20262, INO 495) 是一种核苷,由次黄嘌呤通过β-N9-糖苷键结合到核糖环上形成。
S2280 Chlorogenic Acid Chlorogenic acid (NSC 407296, Heriguard) 是一种羟基肉桂酸,是天然存在的有机化合物。
S6250 L-Lactic acid L-Lactic acid是一种天然产物,可被用作食物添加剂。
S6275 (−)-β-Pinene (−)-β-Pinene (Nopinene)是存在于很多植物中的天然有机化合物。它对滨藜第三龄幼虫具有致死性(LD50 = 65 μg/larva)、抑制感染性支气管炎病毒的肤质(IC50 = 1.32 mM),在Vero细胞中毒性浓度CC50大于10 mM。
S6287 3-Methylbutanoic acid 3-Methylbutanoic acid (Isovaleric acid, Delphinic acid, 3-Methylbutyric acid, Isopentanoic acid, β-methylbutyric acid)是一种天然脂肪酸,广泛存在于多种植物和精油中。
S6296 Octanoic acid Octanoic acid (caprylic acid)天然存在于多种哺乳动物的乳汁(奶)中,是椰子油和棕榈仁油中的微量组分。它被用于生产香水酯类,也用于制作染料。
S6303 trans-2-Hexenal Trans-2-hexenal (Leaf aldehyde)是α,β不饱和羰基化合物,可保护植物免受有害物质侵染。
S5887 Khellin Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin)分离自阿密茴(伞形科)种子,被用于治疗多种疾病。
S2331 Neohesperidin Dihydrochalcone (Nhdc) Neohesperidin dihydrochalcone(Nhdc, NCI-c60764) 是源于柑橘类的一种人造甜味剂。
S9432 Ginkgolic Acid Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).
S9445 Ginkgolic Acid (C13:0) Ginkgolic Acid (C13:0) 是银杏中的一种天然抗龋剂,对变形链球菌(S. mutans)具有抗菌活性,并能抑制与其致龋性相关的特定毒力因子。银杏酸是一种有效的 sumoylation 抑制剂,据报道可抑制 histone acetylation transferase (HAT)
S2360 Solanesol (Nonaisoprenol) Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.
S2369 Troxerutin Troxerutin 是一种黄酮醇类,是一种黄酮类化合物。
S5934 (-)-Fenchone Fenchone是苦艾酒中的组分,是茴香中的香精油。在食物和香水中,它被用做调料(香料)。
S6055 (S)-(−)-Limonene (S)-(−)-Limonene是一种发现于橘皮油中的香料单萜,天然存在于草本精油、茶树油和松节油中。
S6058 β-Caryophyllene β-Caryophyllene是一种天然存在的双环倍半萜烯,是很多精油的组分之一。它是非类固醇的抗炎药物、香料和代谢物。
S6059 cis-3-Hexen-1-ol cis-3-Hexen-1-ol (Leaf alcohol)是一种重要的芳香族化合物,用于果蔬香精和香水中,也是捕食性昆虫的引诱剂。
S6118 Terpinen-4-ol Terpinen-4-ol是一种天然存在的单萜,是茶树油的主要活性成分,具有多种生物活性如抗真菌活性。
S6150 Farnesyl Acetate (mixture of isomers) Farnesyl Acetate是一种香料化合物,可在一些食物如蓝莓中发现。
S6162 2-Octenoic acid 2-Octenoic acid (2-Octenoate)是一种正常的有机酸,由脂族醛通过肝脏微粒体氧化产生。它是天然存在于尿液和血浆中的代谢物。
S6164 (-)-Citronellal (-)-Citronellal是香茅油的组分,用于活性化合物的合成。
S6185 Arachidonic acid Arachidonic acid (Arachidonate)是非饱和必需脂肪酸,在动物和人类肝脏、脑部和腺器官脂肪中都有发现。它是前列腺素、凝血噁烷和白细胞三烯的生物合成的前体化合物。
S6208 Diethyl malonate Diethyl malonate天然存在于葡萄和草莓中,用于合成其他化合物。
S9476 Dendrobine Dendrobine是一种分离自石斛的植物碱,用于对石斛兰Dendrobium的质量控制和鉴别。
S9551 Uvaol Uvaol是一种从橄榄渣油的非甘油酯组分发现的五环三萜,具有促炎-抗炎活性。
S4792 N-Acetylneuraminic acid N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.
S5526 β-Alanine β-Alanine (beta-Alanine, 3-Aminopropanoic acid) is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activating glycine and GABA receptors.
S4676 Gluconolactone Gluconolactone是一种天然存在的聚羟基酸,具有螯合金属离子、保湿、抗氧化活性。
S5851 4'-Methoxychalcone 4'-Methoxychalcone存在于柑橘属植物中,是一种查耳酮衍生物,具有多种药理活性,如抗肿瘤和消炎活性。
S9481 Blinin Blinin可从Conyza blinii中分离,在中国的西南地区被用作民间药物。
S9557 Isobergapten Isobergapten是一种香豆素,具有调节植物生长活性。
S9560 Anisodamine Hydrobromide Anisodamine (6-Hydroxyhyoscyamine)是天然存在的阿托品(atropine)衍生物,具有消炎活性。它能抑制α1-adrenergic receptorsmAChRs
S5865 Hyaluronic acid Hyaluronic acid (HA, Hyaluronan, Hyaluronate)(透明质酸)是一种带阴离子的、非硫酸化的粘多糖,在结缔组织、上皮和神经组织中广泛分布。它常用于皮肤护理。
S9193 Aristolochic acid A Aristolochic acid A (Aristolochic Acid I, Aristolochin, Aristolochine, TR 1736)是一种致癌、致突变和具有肾毒性的试剂,来源于马兜铃科的开花植物。Aristolochic acid A 可显著降低 activator protein 1 (AP-1)nuclear factor-κB (NF-κB) 的活性。
S9563 Evodine Evodine是一种天然产物(源于吴茱萸),在中国药典中被记载作为吴茱萸质量评估的生物标志物。Evodine 也是一种有效的 P-gp 的抑制剂。
S9554 Bakkenolide A Bakkenolide A (Fukinanolid)分离自毛裂蜂斗菜,具有抗癌活性,可对炎性细胞因子的形成发挥保护作用。
S9552 Farrerol Farrerol是杜鹃花中一种重要的活性成分,具有抗氧化和消炎活性。
S9487 Praeruptorin C Praeruptorin C是源于白花前胡干燥根的天然产物,具有抑制破骨细胞形成和吸收的作用。它常常在中药中被用于治疗上呼吸道感染,是解热、镇咳和促黏液溶解的试剂。
S9484 Darutoside Darutoside源于植物提取物,通过减少炎症反应和修复胶原发挥有效的再生活性。
S9480 Raspberry Ketone Raspberry ketone (p-Hydroxybenzyl acetone, Frambinone, Oxyphenylon, Rheosmin, Rasketone)是一种天然存在的酚类化合物,是红莓中的主要芳香化合物。
S9473 Nuzhenide Nuzhenide (Specnuezhenide)是橄榄仁中的重要成分,属于糖脂类。
S9474 Acetylharpagide Acetylharpagide是来源于金疮小草(Ajuga decumbens)的一种单体化合物,广泛用于治疗传染性和炎症性疾病。
S5846 Apocarotenal Apocarotenal是一种类胡萝卜素,可存在于菠菜和柑橘类水果中,是维他命A的前体。
S9475 Hupehenine Hupehenine是来源于湖北贝母鳞茎的甾体生物碱,具有抑制乙酰胆碱、拮抗毒蕈碱性受体、抑制胆碱酯酶的潜力。
S9479 Complanatoside A Complanatoside A是分离自沙苑子(Astragalus complanatus)中的一种黄酮苷,可被用作沙苑子的质量控制指标。
S9488 Praeruptorin D Praeruptorin D是前胡中的成分,具有抗肿瘤和消炎活性。
S9491 (+)-Guaiacin (+)-Guaiacin存在于草药和香料中,属于木脂素类。
S9555 Vincristine Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) 是长春花中的生物碱,具有抗肿瘤活性。Vincristine 可抑制有丝分裂纺锤体中的微管 microtubule 形成,其结合微管的Ki值为85 nM。
S9562 Pomolic acid Pomolic acid是一种分离自野鸦椿(Euscaphis japonica)的五环三萜,可有效地抑制细胞生长和诱导凋亡。
S9192 Vitexin Vitexin (Apigenin-8-C-glucoside), an naturally occuring apigenin flavone glycoside, acts as a platelet aggregation and alpha-glucosidase inhibitor and shows antineoplastic activity.
S3964 Mucic Acid Mucic Acid (Schleimsaure, Saccharolactic acid, Tetrahydroxyadipic acid, D-Glucaric acid, Galactaric acid) is the dicarboxylic sugar acid resulting from oxidation glactose with dilute nitric acid. It is a substrate of galactarate O-hydroxycinnamoyltransferase.
S5928 Zerumbone Zerumbone,分离自姜科植物,是一种天然存在的膳食化合物,具有多种生化活性,如抗增殖、抗氧化、消炎和抗癌活性。
S5794 Glycochenodeoxycholic acid Glycochenodeoxycholic acid (Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate)是由鹅去氧胆酸盐和甘氨酸在肝脏中形成的胆汁盐。它是一种去垢剂,能溶解脂肪,促进吸收。
S5820 L-Hydroxyproline L-Hydroxyproline (trans-4-Hydroxy-L-proline)是一种胶原特异的氨基酸。它被用作骨转换和肝纤维化的诊断标记物。
S5824 Cinnamyl alcohol Cinnamyl alcohol是一种存在于肉桂中的天然产物。
S5821 Linoleic acid Linoleic acid (9,12-octadecadienoic acid)是一种必需脂肪酸,用于合成花生四烯酸,存在于细胞膜脂质中。
S5823 L-Pyroglutamic acid L-pyroglutamic acid (L-pyroglutamate, 5-Oxoproline, pidolic acid)是一种天然营养物,是来源于谷氨酸的氨基酸。它是谷胱甘肽循环的代谢物,能通过5-羟脯氨酸酶转化为谷氨酸。
S5828 L-Abrine L-Abrine (N-Methyl-L-tryptophan)是相思子根部的毒性清蛋白,可抑制核糖体。
S9367 Adenosine disodium triphosphate Adenosine disodium triphosphate (ATP disodium) is the sodium salt form of adenosine triphosphate (ATP), a complex organic chemical that provides energy to drive many processes in living cells.
S5805 Allopregnanolone Allopregnanolone是一种神经类固醇,在脑内由黄体酮合成而来,是高效的GABAA receptor正向别构调节剂。
S5771 Sulforaphane Sulforaphane 是一种天然存在的异硫氰酸盐,存在于十字花科蔬菜如西兰花、卷心菜、羽衣甘蓝。它是 Nrf2 的诱导物。Sulforaphane 也是 histone deacetylase (HDAC)NF-κB 的抑制剂。Sulforaphane 可增加 heme oxygenase-1 (HO-1),并降低 reactive oxygen species (ROS) 的水平。Sulforaphane 诱导细胞周期停滞和凋亡。
S9334 2-Pentylfuran 2-Pentylfuran (2-Amylfuran)是天然存在的香料成分。
S9383 Methyl palmitate Methyl palmitate (Methyl hexadecanoate, Palmitic acid methyl ester), a kind of fatty acid methyl ester, could be found in many plants and possesses acaricidal activity.
S9453 2-Undecanol 2-Undecanol (Methyl nonyl carbinol, 2-Hydroxyundecane, 2-Hendecanol) is a fatty alcohol lipid molecule.
S9454 Undecanoic acid Undecanoic acid (Undecylic acid) is a medium chain length monocarboxylic acid that appears to be involved in the control of triacylglycerol synthesis.
S9385 Ligustilide Ligustilide is the most abundant bioactive ingredient in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments. 现配现用
S9033 Incensole acetate Incensole acetate, isolated from Boswellia Resin, is a novel anti-inflammatory compound that inhibits NF-κB activation.
S9043 6-Shogaol 6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties.
S9071 Nootkatone Nootkatone, a natural ingredient that occurs in grapefruit and certain other plants, has antioxidant and anti-inflammatory effects.
S9094 Pogostone Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.
S9118 Beta-Asarone Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects.
S9140 Pulegone Pulegone, a naturally occurring organic compound, is a fragrance and flavour ingredient.
S9142 Sparteine Sparteine, which could be extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent.
S9236 α-Cyperone α-Cyperone (alpha-cyperone) 是香附子Cyperus rotundus的主要活性成分,表现出了如抗毒力、抗原毒性和抗菌活性等生物活性。α-Cyperone (alpha-cyperone) 与COX-2IL-6Nck-2Cdc42Rac1 的表达下调有关。
S9263 3-n-Butylphathlide 3-n-Butylphathlide, initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects.
S5370 10-Hydroxydecanoic acid 10-Hydroxydecanoic acid, a minor constituent of royal jelly, is a saturated fatty acid that has cytotoxic effects.
S9450 1-Undecanol 1-Undecanol (Undecyl alcohol, 1-Hendecanol), found naturally in many foods such as fruits (including apples and bananas), butter, eggs and cooked pork, is used as a flavoring ingredient.
S5761 Citric acid Citric acid is a weak organic acid that occurs naturally in citrus fruits. It is an intermediate in the citric acid cycle.
S5763 D-Mannose D-mannose is a naturally occurring simple sugar that may help your body cleanse the urinary tract and maintain a healthy bladder lining.
S5391 α-Boswellic acid α-Boswellic acid is a naturally occuring triterpenoic acid.
S5757 Isoeugenol Isoeugenol (4-Propenylguaiacol), an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity.
S5759 Methyl linoleate Methyl linoleate (Linoleic acid methyl ester), found in cloves, is a fatty acid methyl ester of linoleic acid which is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes.
S5756 Methyl Stearate Methyl Stearate (Methyl Octadecanoate, Stearic Acid methyl ester), found in cloves, is an antifoaming agent and fermentation nutrient.
S5577 6-Biopterin 6-Biopterin ( L-Biopterin, L-Erythro-Biopterin) is a natural product that has been considered as a growth factor for some insects.
S5743 γ-Linolenic acid γ-Linolenic Acid (18:3, n-6), the Δ6-desaturase product of linolenic acid, is an unsaturated fatty acid found primarily in vegetable oils.
S5600 Flavokawain A Flavokawain A 是一种从 kava 提取的凋亡诱导剂和抗癌剂。 Flavokawain A 可以下调抗凋亡蛋白,例如 XIAP、 survivin 和 Bcl-xL,从而改变凋亡与抗凋亡分子之间的平衡、诱导肿瘤细胞死亡。
S5732 Sebacic acid Sebacic acid (1,8-Octanedicarboxylic acid) is a saturated, straight-chain naturally occurring dicarboxylic acid
S5733 Stearic acid Stearic acid (Octadecanoic acid, Isostearic acid, Cetylacetic acid) is a natural saturated fatty acid found in animal and vegetable fats. It could be used as a food additive and used in soaps, cosmetics and detergents.
S9375 2'-Hydroxyacetophenone 2'-Hydroxyacetophenone is a flavouring ingredient.
S9379 Dihydrocoumarin Dihydrocoumarin, a compound found in Melilotus officinalis (sweet clover) and Dipteryx odorata Willd (tonka beans), is added as a flavoring agent to a wide variety of foods, including soft drinks, yogurt, and muffins, and is used as a common fragrance in cosmetics, lotions, and soaps.
S9382 Thymine Thymine (5-methyluracil) is one of the four nucleobases in the nucleic acid of DNA.
S9333 Gibberellins A4/A7 Gibberellins A4/A7 (Gibberellin A4 and A7) is the Gibberellin A4 Mixture With Gibberellin A7. Gibberellins A4/A7 promotes internode elongation & breaks certain dormancies in seeds. Gibberellins A4/A7 is an endogenous plant growth regulator, promotes the growth and elongation of cells.
S5691 Terpinyl Acetate Terpinyl Acetate (alpha-Terpinyl), a naturally occuring compound found in several essential oils, is a flavouring agent.
S5616 4-Methylcatechol 4-Methylcatechol (P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol) is an inducer of nerve growth factor. It is used to synthesize antimicrobial and antioxidant.
S9352 Homogentisic Acid Homogentisic Acid (Melanic acid, 2,5-dihydroxyphenylacetic acid) is found in Arbutus unedo (strawberry-tree) honey or present in the bacterial plant pathogen Xanthomonas campestris pv. phaseoli as well as in the yeast Yarrowia lipolytica.
S5684 Lapachol Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.
S5640 Ethyl caffeate Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro.
S5680 (-)-Verbenone (-)-Verbenone (2-Pinen-4-one), an important component of the essential oil from rosemary, is an insect pheromone with a spicy odor and camphoraceous fragrance.
S5617 Myristic Acid Myristic acid (Tetradecanoic acid) is a fatty acid that occurs naturally in some foods. Myristic acid inhibits the phosphorylation of poly E4Y by Src with an Ki of 35 μM.
S9046 Berberine Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.
S9047 Leonurine Hydrochloride Leonurine (SCM-198), a natural alkaloid extracted from Herba leonuri, is a promising anti-glycation agent with vasodilator, antioxidative, cardioprotective and neuroprotective effects.
S9037 Tenacissoside H Tenacissoside H, a natural compound found in M. tenacissima, exerts anti-inflammatory and anti-tumor effects.
S9027 Corynoxine Corynoxine, a natural oxindole alkaloid, is a new autophagy enhancer.
S9041 Corosolic acid Corosolic acid (Glucosol, Colosic acid, 2α-Hydroxyursolic acid) is one of the pentacyclic triterpenoids isolated from Lagerstroemia speciose and has been reported to exhibit anti-cancer and anti-proliferative activities in various cancer cells.
S9035 Isovitexin Isovitexin (saponaretin, Apigenin-6-C-glucoside), an active component of many traditional Chinese medicines, has various activities, such as anti-oxidant, anti-inflammatory, anti-alzheimer disease (AD) effects and so on.
S9032 Sanguinarine Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation.
S9036 (20R)Ginsenoside Rh2 (20R)Ginsenoside Rh2, a natural compound found in Panax ginseng, shows antiviral and anticancer activities. It is a matrix metalloproteinase (MMP) inhibitor.
S9024 3-O-Acetyl-11-keto-β-boswellic acid (AKBA) 3-O-Acetyl-11-keto-β-boswellic acid (AKBA), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase.
S9044 Ginsenoside F2 Ginsenoside F2, a ginsenoside found in Panax species, is an autophagic initiater with anti-cancer, and anti-obesity activities.
S9042 Wedelolactone Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11.
S9030 Tenacissoside I Tenacissoside I is a natural compound found in M. tenacissima at relatively high level.
S5677 Xanthopterin Hydrate Xanthopterin, isolated from butterfly wings and found in many other sources, replace folic acid in the nutrition of many animal species.
S9353 L-serine L-serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
S9349 D-(+)-Raffinose pentahydrate Raffinose is a trisaccharide composed of galactose, glucose, and fructose.
S9341 3,4-Dimethoxycinnamic acid 3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.
S9344 DL-Methionine DL-Methionine is an amino acid that has a role in the defence of oxidative stress.
S9004 Chondroitin 4-sulfate Chondroitin 4-sulfate is an important structural component of cartilage and has been used as a dietary supplement to treat symptoms of joint discomfort.
S9373 Neryl acetate Neryl acetate (Nerol, Acetic acid neryl ester, cis-Geranyl), a chemical compound found in citrus oils, is a flavouring agent.
S9339 S-(-)-Cotinine S-(-)-Cotinine, a constituent of tobacco products and the major metabolite of nicotine, stimulates nicotinic receptors to evoke the release of DA in a calcium-dependent manner from superfused rat striatal slices.
S9372 Ethyl palmitate Ethyl palmitate (Ethyl hexadecanoate, Palmitic acid ethyl ester) is a long-chain fatty acid ethyl ester that is used as a hair- and skin-conditioning agent.
S4937 4'-Hydroxychalcone 4'-Hydroxychalcone (P-Cinnamoylphenol),存在于草药、香料和茶叶中,是一种刺甘草查尔酮。它具有多种生物活性,能够抑制TNF-α诱导的NF-κB通路激活、并激活BMP信号通路。
S3622 Diammonium Glycyrrhizinate Diammonium glycyrrhizinate (DG)是一种传统的中草药,从甘草中提取纯化而来。它具有抗炎活性,对生物氧化具有抗性、对膜具有保护性。DG通过抑制NF-κB、TNF-α和细胞间黏附分子1来减少炎症损伤。
S3769 Palmatine Palmatine (Berbericinine, Burasaine), an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.
S3788 Carvacrol Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.
S5176 Fructose Fructose (D-(-)-Fructose, Fruit sugar, levulose, fructosteril, D-fructofuranose, D-arabino-hexulose) is a simple ketonic monosaccharide found in many plants.
S5178 4-Hydroxy-2,5-dimethyl-3(2H)furanone 4-Hydroxy-2,5-dimethyl-3(2H)furanone (furaneol, HDMF) is a naturally occurring substance found in a variety of fruits and has been shown to have antimicrobial activity.
S5592 Vitamin A Vitamin A (Retinol) is a naturally occuring fat-soluble vitamin that is important for normal vision, the immune system, and reproduction. It also plays roles in normal functioning of heart, lungs, kidneys, and other organs.
S5591 Ectoine Ectoine ( THP(B)) is a natural amino acid derivate with membrane stabilizing and inflammation reducing capacities. It is produced by bacteria living under extreme harsh environmental conditions where it serves as osmoregulatory compatible solute.
S4888 Guanine Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA.
S5505 2’-deoxyuridine 2'-deoxyuridine (dU, 2'-dU) is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms.
S5503 O-Acetyl-L-carnitine hydrochloride O-Acetyl-L-carnitine (Acetyl-L-carnitine, O-acetyl-L-carnitine, O-Acetylcarnitine) can be synthesis or is naturally found in healthy humans. It could help transport fatty acids into the mitochondrial matrix where fatty acid metabolism occurs.
S9368 ADP ADP (Adenosine diphosphate, adenosine pyrophosphate, Adenosine 5'-diphosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells.
S5550 Ethyl gallate Ethyl gallat (Phyllemblin, gallic acid ethyl ester), which could be found naturally in a variety of plant sources, is a food additive with antimicrobial activity.
S9390 Astragaloside II Astragaloside II, extracted from Astragalus membranaceus, has been reported to promote tissue wound repair and could be a potential adjunctive agent in cancer chemotherapy, enhancement of osteogenesis, and modulation of T cell activation.
S9166 Griffonilide Griffonilide is a natural product that has been reported to induce bone remodeling activity resulting in structural changes.
S9169 Polygalasaponin F
S9198 Obtusifolin Obtusifolin is anthraquinone found in the seeds of Cassia obtusifolia, has inhibitory effects on platelet aggregation and aldose reductase.
S9220 Stylopine hydrochloride Stylopine (Tetrahydrocoptisine, Coptisine), a major component of the leaf of Chelidonium majus L., is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
S9241 Polygalaxanthone III Polygalaxanthone III 是一种天然产物,具有镇静,减轻感冒,消除痰液和消肿的功效。Polygalaxanthone III 抑制 CYP2E1 催化的氯唑沙宗6-羟基化反应,IC50值为50.56 μM。
S9259 Lithospermic acid Lithospermic acid, an active component isolated from Salvia miltiorrhiza radix, is known to have multiple pharmacological actions such as antihypertensive and antioxidant effects.
S9262 Raddeanin A Raddeanin A (Raddeanin R3, NSC382873), a triterpenoid saponin from Anemone raddeana Regel, displays moderate inhibitory activity against histone deacetylases (HDACs) and has high antiangiogenic potency, antitumor activity.
S9264 Decursin Decursin (D), purified from Angelica gigas Nakai, shows potential anti-inflammatory activity and neuroprotective property.
S9306 Corynoxeine Corynoxeine, which could be isolated from Uncaria rhynchophylla, is a useful and prospective compound in the prevention and treatment for vascular diseases. It is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation.
S9310 Isorhychophylline Isorhynchophylline (IsoRhy, 7-Isorhyncophylline) is a major tetracyclic oxindole alkaloid isolated from the Chinese herbal medicine Uncaria rhynchophylla (Miq.)Jacks (Gouteng in Chinese). It acts as a neuronal autophagy inducer with therapeutic potential for cardiovascular and central nervous system diseases.
S9414 Cyasterone Cyasterone is the main phytoecdysteroid component found in Cyathula capitata. It is a natural EGFR inhibitor and maybe a promising anti-cancer agent.
S9448 D-(+)-Turanose D(+)-Turanose is a naturally occuring compound. It is a reducing disaccharide.
S5745 Glyceryl 1,3-dipalmitate Glyceryl 1,3-dipalmitate acts as a metabolite of saccharomyces cerevisiae, plant and human.
S9507 (−)-Norepinephrine (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline)是一种天然存在的神经递质和激素。它是adrenergic receptors的激动剂,对α1, α2A和β1肾上腺素受体的Ki值分别为330 nM、56 nM和740 nM。
S9505 Oleanonic Acid Oleanonic Acid (3-Ketooleanolic Acid, 3-Oxooleanolic acid), extracted from Pistacia terebinthus galls, is a cell cycle inhibitor and used as antitumor agents.
S5686 Tryptanthrin Tryptanthrin is a natural alkaloidal compound having basic indoloquinazoline moiety. It has broad spectrum of biological activities including anticancer activity, anti-inflammatory, antiprotozoal, antiallergic, antioxidant, and antimicrobial.
S5690 Triacanthine Triacanthine, which could be isolated from the leaves of G. triacanthos, shows hypertensive activity, also cardiotonic, antispasmodic and a respiratory analeptic.
S5554 Lanatoside C Lanatoside C 是具有抗病毒和抗肿瘤活性的强心苷。Lanatoside C 通过减弱 MAPK,Wnt,JAK-STAT和PI3K/AKT/mTOR信号通路,诱导G2/M细胞周期停滞并诱导自噬和细胞凋亡。
S5312 Urolithin A Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.
S3817 Harmine hydrochloride Harmine (Telepathine)是属于β-咔啉家族化合物的一种荧光harmala生物碱,是一种高细胞渗透性的 DYRK1A 的激酶口袋结合ATP的竞争性抑制剂,与DYRK2结合IC50值高约60倍。Harmine 还可以抑制 monoamine oxidases (MAOs)cdc-like kinases (CLKs)。Harmine 抑制 5-HT2A serotonin receptor 的Ki值为397 nM。
S5318 Acacetin Acacetin (Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin) is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.
S9345 Disodium 5'-Inosinate Disodium 5'-Inosinate, widely distributed in all animal and plant tissues, is used as a flavor enhancer.
S9059 4'-O-Glucosylvitexin 4'-O-Glucosylvitexin is a kind of flavonoid fraction from the leaves of Crataegus pinnatifida.
S9364 6-Hydroxycoumarin 6-Hydroxycoumarin demonstrates cytotoxic effect against the cancer cell lines.
S9365 Disodium uridine-5'-monophosphate Disodium uridine-5'-monophosphate is a nucleotide that is a major component of ribonucleic acid.
S9366 5'-Adenylic acid AMP, also known as 5'-Adenylic acid and Adenosine monophosphate, is a nucleotide that is found in RNA. It is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet.
S9369 Xanthosine Xanthosine (Xanthine riboside) is an intermediate in purine metabolism, formed from IMP, and forming GMP.
S9370 Adenosine Cyclophosphate Adenosine Cyclophosphate (Cyclic adenosine monophosphate, cAMP, cyclic AMP, 3',5'-cyclic adenosine monophosphate) is useful for improving myocardial hypoxia, dilating coronary artery and strengthening myocardiac contraction.
S9384 Sophocarpine Monohydrate Sophocarpine, a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities.
S9386 Polygalacic acid Polygalacic acid 是从远志属植物(Polygala paenea L.)分离出的三萜类四羟酸。Polygalacic acid (0-100μM; 24h) 可以显著降低 MMP-3、MMP-9、MMP-13 和 COX-2 的mRNA表达,这些因子的表达由IL-1β诱导可显著增加,并呈现出剂量依赖性。
S9387 Maackiain Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.
S9388 (+)-Praeruptorin A Praeruptorin A is a coumarin compound naturally occurring in the roots of Peucedanum praeruptorum Dunn., a commonly used traditional Chinese medicine for the treatment of certain respiratory diseases and hypertension. Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of NF-κB activation. (+)-Praeruptorin A is one of enantiomers.
S9389 Phorbol Phorbol is a natural, plant-derived organic compound that exerts a broad range of biological activities.
S9401 3,6'-Disinapoyl sucrose 3,6'-Disinapoyl sucrose (Disinapoyl sucrose), an oligosaccharide ester natural product originating from the root of wild Polygala tenuifolia, has neuroprotective effects and antidepressive activity in rats.
S9400 Rhynchophylline Rhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension.
S9398 Crassicauline A Crassicauline A, a diterpenoid alkaloid in Aconitum herbs, is an analgesic drug clinically used in China.
S9397 Alliin Alliin (S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine) is a sulfoxide that is a natural constituent of fresh garlic.
S9396 Geraniin Geraniin, a hydrolysable polyphenol derived from Nephelium lappaceum L. fruit rind, has been shown to possess significant antioxidant activity in vitro.
S9392 Praeruptorin B Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities.
S9402 (20R)-Protopanaxadiol (20R)-Protopanaxadiol, isolated from the roots of Panax ginseng, has protective effect on myocardial ischemia.
S9404 Pristimerin Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon.
S9405 Sesamoside Sesamoside, a main chemical ingredient iridoid glycoside from Lamiophlomic rotata, has analgesic and anti-inflammatory effects in animal studies.
S9406 Sauchinone Sauchinone, one of the active lignan isolated from the roots of Saururus chinensis, possesses diverse pharmacological properties, such as hepatoprotective, anti-inflammatory and anti-tumor effects.
S9407 Angoroside C Angoroside C, an important phenylpropanoid glycoside of the traditional Chinese medicine Scrophulariae Radix, possesses the effects of preventing ventricular remodeling, reducing pulmonary oedema, and reducing blood pressure, as well as having the properties of anti-platelet aggregation, hepatoprotection and anti-nephritis, etc.
S9408 Beta-Elemonic acid Beta-Elemonic acid (3-Oxotirucallenoic Acid), a known triterpene isolated from Boswellia (Burseraceae), exhibits anti‑inflammatory effects.
S9409 Kavain Kavain, the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels.
S9410 Euphorbia factor L1 Euphorbia factor L1, a diterpenoid isolated from Euphorbia lathyris, inhibits osteoclastogenesis and induces osteoclast apoptosis.
S9411 Liensinine Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.
S9412 Flavokawain B Flavokawain B is a natural chalcone first isolated from extracts of kava roots that induces apoptosis in cancer cells.
S9413 Yangonin Yangonin (Y100550) is a dienolide kavalactone originally found in Piper methysticum (kava plant) and exhibits neuroprotective, neuromodulatory, and antifungal activities. It activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors.
S9416 Triptonide Triptonide, isolated from the roots of Tripterygium wilfordii, can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. It is also an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent.
S9417 Homoplantaginin Homoplantaginin (Hispidulin-7-glucoside) 是中草药丹参中的主要类黄酮,具有抗炎和抗氧化作用。Homoplantaginin 可抑制 TNF-αIL-6 mRNA 表达,IKKβNF-κB 磷酸化。
S9420 Sinoacutine Sinoacutine (Salutaridine), isolated from the Chinese drug Ching-fengteng, elicits mild antitussive properties.
S9421 Demethylnobiletin Demethylnobiletin (5-Demethylnobiletin)是一种在柑橘类水果中发现的独特的类黄酮,具有潜在的化学预防人类癌症的作用。5-Demethylnobiletinin 是 5-LOX 的直接抑制剂,IC50值为0.1 μM,且不影响COX-2的表达。5-Demethylnobiletinin 具有抗炎活性,可抑制大鼠中性粒细胞中 leukotriene B 4(LTB4) 的形成和人中性粒细胞中elastase弹性蛋白酶 (elastase) 的释放,IC50为0.35 μM。
S9422 Diosbulbin B Diosbulbin B is the main hepatotoxic compound in Airpotato yam, which is traditionally used for treating thyroid disease and cancer.
S9423 Narcissoside
S9425 Trifolirhizin Trifolirhizin, a natural pterocarcan flavonoid extracted from Sophora flavescens, has many pharmacological activities, such as hepatoprotective, anti-inflammatory, anti-proliferation, and skin-whitening.
S9427 Tabersonine Tabersonine is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus and shows hypotensive activity, anti-tumor activity, hypoglycemic, diuretic activity.
S9428 Brazilin Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.
S9429 6α-Hydroxygeniposide 6α-Hydroxygeniposide, an iridoid glycoside, is a chemical constituents of Pittosporum glabratum Lindl.
S9430 Tomatidine Hydrochloride Tomatidine Hydrochloride, a natural steroidal alkaloid, possesses potent antibacterial activity and has anti-inflammatory effects in macrophages.
S9431 Dehydrocorydalin Dehydrocorydalin is an alkaloidal component isolated from Rhizoma corydalis. It has anti-inflammatory and anti-tumor effects and can protect the cardiovascular system.
S9433 Tubeimoside II Tubeimoside II (Tubeimoside B), a natural triterpenoid saponin isolated from herb, show anti-inflammatory, antitumor, and antitumor-promoting effects.
S9434 8-Gingerol 8-Gingerol is a bioactive ingredient of ginger root (Zingiber officinale), a medicinal plant having anti-nausea, anti-inflammatory, and anti-carcinogenic properties and a carminative effect.
S9435 Secoxyloganin Secoxyloganin is a secoiridoids that is extensively used in synthetic and biosynthetic studies of monoterpene indole alkaloids and related natural products.
S9436 Pinoresinol dimethyl ether Pinoresinol dimethyl ether, which could be isolated from the wood of the basal tree Humbertieae, show a variety of activities as the inhibitor of cyclic AMP phosphodiesterase.
S9437 Echinatin Echinatin is a licorice extract that displays antioxidant properties and anti-inflammatory activities.
S9438 Isosakuranetin Isosakuranetin (4'-Methylnaringenin), an O-methylated flavonoid, is the 4'-methoxy derivative of naringenin, a flavanone found in Citrus species.
S9120 Scutellarein Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities.
S9439 Kaurenoic acid Kaurenoic acid (kaurenoate, kaur-16-en-18-oic acid) is a natural diterpenoid found in the herbs of Croton antisyphiliticus. Kaurenoic acid has anti-inflammatory activity, the mechanisms may through inhibition of iNOS and COX-2 expression.
S9441 Sibiricose A5 Sibiricose A5, which could be isolated from traditional Chinese medicine Polygalae Radix, shows potent antioxidant activity.
S9442 Bergaptol Bergaptol (5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin)是在柠檬、佛手柑等柑橘精油中发现的天然呋喃香豆素。Bergaptol 是有效的 CYP3A4 酶脱苄基活性抑制剂,IC50值为24.92 μM。
S9443 Schisantherin B Schisantherin B is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine.
S9444 Tomatine Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties.
S9446 Dihydrokavain Dihydrokavain (Marindinin) is a kavalactone source from kava beverages used in herbal medicine to treat sleep disturbances, as well as stress and anxiety.
S9447 1F-Fructofuranosylnystose 1F-Fructofuranosylnystose is a kind of Fructooligosaccharides which are naturally occurring sugars with potentially beneficial nutritional effects.
S9503 Fraxetin Fraxetin (7,8-dihydroxy-6-methoxy coumarin), found in Fraxinus rhynchophylla, shows potent antioxidant activity.
S9502 Madecassic acid Madecassic acid (Brahmic acid) 是最早从积雪草中分离的天然三萜,具有多种消炎和抗糖尿病作用,阻断巨噬细胞中的 NF-κB 活化并导致 iNOSCOX-2TNF-alphaIL-1betaIL-6 抑制。
S9001 Malic acid Malic acid (Hydroxybutanedioic acid, 2-Hydroxysuccinic acid) is a common, naturally occurring ingredient in many foods. It is the main acid found in apples and other fruits.
S9002 L-Fucose Fucose (6-Deoxy-L-Galactose, L-fucopyranose) is found on N-linked glycans on the mammalian, insect and plant cell surface. L-Fucose is claimed to have application in cosmetics, pharmaceuticals, and dietary supplements.
S9006 Perillartine Perillartine (Perilla sugar, Peryllartine) is a sweetener.
S9014 AstragalosideⅠ AstragalosideⅠ, is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.
S5083 Lentinan Lentinan (A823605, Bromoduline),分离纯化自香菇子实体水煮提取物,是一种真菌多糖免疫调制剂,具有抗肿瘤活性。
S9272 Koumine Koumine, a Gelsemium alkaloid, possesses analgesic, anti-inflammatory and neurosteroid modulating activities.
S9273 Timosaponin BII Timosaponin BII (BII, Prototimosaponin AIII) is a steroidal saponin showing potential anti-dementia and antioxidant activity.
S9274 Isochlorogenic acid B Isochlorogenic acid B, naturally isolated from Laggera alata, has antioxidative and hepatoprotective properties.
S9275 Isoguanosine Isoguanosine (Crotonoside)抑制 FLT3 和 HDAC3/6 治疗AML。Isoguanosine 是巴豆(Croton tiglium)种子中天然存在的鸟苷的活性异构体。
S9276 Alisol B Alisol B, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.
S9277 Alisol A Alisol A is one of the major active triterpenes isolated from Rhizoma Alismatis (RA), a famous Traditional Chinese Medicine widely used for diuretic, hypolipidemic, anti-nephrolithic, anti-atherosclerotic, anti-inflammatory and anti-diabetic purposes.
S9278 Saikosaponin C Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.
S9279 Euphorbia factor L3 Euphorbia factor L3 (5,15-Diacetyl-3-benzoyllathyrol), belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed, shows potent cytotoxicity and induces apoptosis via the mitochondrial pathway in A549 cells.
S9280 Demethoxycurcumin Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties.
S9281 Peimine Peimine (Verticine, Wanpeinine A) is a major biologically active component of Fritillaria ussuriensis, exhibits anti-inflammatory and pain suppression properties at the cellular level.
S9267 Epimedin A Epimedin A is a major component of Herba Epimedii with bioactivities.
S9268 Epmedin B Epmedin B (Epimedin B) is a component extracted from Epimedii Folium and may have antiosteoporotic activity.
S9269 Epmedin C Epmedin C (Epimedin C, Baohuoside VI), a flavonoid isolated from the herbs of Epimedium brevicornum Maxim, exhibits immunostimulatory and anticancer activities.
S9270 Dracohodin perochlorate Dracohodin perochlorate, extracted from Dragon's blood, is widely used in traditional Chinese medicine, especially in wound healing.
S9271 Pulchinenoside A Pulchinenoside A (Anemoside A3), a natural triterpenoid saponin, is a AMPARs and NMDAR modulator.
S9282 Isochlorogenic acid A Isochlorogenic acid A (3,5-dicaffeoylquinic acid), isolated from Brazilian propolis and Suaeda glauca, exhibits hepatoprotective and cytotoxic activities.
S9283 Aristolone Aristolone, which could be extracted from essential oil of Elyonurus hensii, is likely to induce an antalgic activity.
S9284 Aloesin Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.
S9285 Fargesin Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.
S9286 Neobavaisoflavone Neobavaisoflavone, isolated from seeds of Psoralea corylifolia, exhibits inhibitory activity against DNA polymerase and platelet aggregation.
S9287 Genkwanin Genkwanin (Apigenin 7-methyl ether) is one of the major non-glycosylated flavonoids in herbs. It has a variety of pharmacological effects including anti-inflammatory, anti-bacterial, antiplasmodial, radical scavenging, chemopreventive and inhibiting 17β-Hydroxysteroid dehydrogenase type 1 activities.
S9288 Casticin Casticin (Vitexicarpin), as the major active substance in Lithospermum erythrorhyzon, had been reported to mediate multiple pharmacological activities such as antioxidation, antiviral, cardiovascular protection, antineoplastic and anti-inflammation.
S9289 Astragalin Astragalin (kaempferol-3-glucoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside), a flavonoid from leaves of persimmon and green tea seeds, has anti-tumor, anti-inflammatory and anti-oxidant activities.
S9290 Linarin Linarin (Acaciin, Buddleoside, Acacetin-7-O-rutinoside), a natural flavonoid cpompound, has pharmacological effects, including anti-inflammatory, neuro-protective, cardioprotective and antioxidative effects.
S9291 Isopimpinellin Isopimpinellin (5,8-Dimethoxypsoralen) is a natural product synthesized by numerous plant species. It may acts as an anticarcinogen.
S9292 Dictamnine Dictamnine, a natural plant product, has been reported to have antimicrobial activity against bacteria and fungi.
S9293 Isoliquiritin Isoliquiritin (Neoisoliquritin) is a flavonoid glycoside compound from licorice possessing a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory, and anti-depression activities.
S9294 Gelsemine Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., is a highly toxic compound and may be a glycine receptor agonist with significantly higher binding affinity for some of these receptors than its native agonist, glycine.
S9295 Dauricine Dauricine, a plant metabolite isolated from the Asian vine Menispermum dauricum, plays a variety of biological roles in the human body, from inhibiting cancer cell growth to blocking cardiac transmembrane Na+, K+, and Ca2+ ion currents.Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF‐κB signaling pathway in colon cancer cells.
S9296 Fraxin Fraxin (Fraxetin-8-O-glucoside), a main active component isolated from Cortex Fraxini, possesses a variety of bioactivities such as anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, immunomodulatory, anti-hyperuricemia and diuresis.
S9297 Kirenol Kirenol is a biologically active substance isolated from Herba Siegesbeckiae. It has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities.
S9298 Corylin Corylin, a main compound isolated from Psoralea corylifolia L. (Fabaceae), has a variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties.
S9300 Methylprotodioscin Methyl protodioscin, a bioactive natural compound isolated from Dioscorea collettii Makino (Dioscoreaceae), has numerous pharmacological activities, including anti-inflammation, lipid-lowering, and anticancer activities.
S9301 Verbenalin Verbenalin (Verbenalol β-D-glucopyranoside, Verbenalol glucoside, Cornin), an iridoid glycoside found in Verbena officinalis, has been reported to exhibit uterine stimulant activity and demonstrated cardioprotection against experimental myocardial ischemic injury.
S9302 Polyphyllin VI Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.
S9303 Saikosaponin B2 Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.
S9304 Platycodin D Platycodin D, the main saponin isolated from Chinese herb Platycodonis Radix, exhibits anti-inflammatory, anti-allergic, cholesterol-lowering and neuroprotective properties.
S9305 Toosendanin Toosendanin, a triterpenoid extracted from Melia toosendan Sieb et Zucc, possesses broad biological actions from blocking neurotransmission and antibotulism to inducing cell differentiation and apoptosis.
S9307 Shanzhiside methyl ester Shanzhiside methylester is a principle effective iridoid glycoside of L. rotata and serves as a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist.
S9308 Pulsatilla saponin D Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla koreana, targets c-Met and exerts antiangiogenic and antitumor activities.
S9309 Micheliolide Micheliolide, a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, inhibits various inflammatory response and may serve as a neuroprotective agent in neuroinflammation-related neurodegenerative disorders.
S9311 Germacrone Germacrone, a major activity component found in Curcuma zedoaria oil product, shows anti-inflammatory, antiandrogenic, and antimicrobial activities.
S9312 Cyanidin-3-O-glucoside chloride Cyanidin-3-O-glucoside chloride (Kuromanin, Chrysontemin, Glucocyanidin) is a natural product with anti-oxidant and neuroprotective effects.
S9313 Atractylenolide III Atractylenolide III, a major component of Atractylodes rhizome, has anti-inflammatory and anti-angiogenesis activities.
S9314 Atractylenolide II Atractylenolide II (AT-II, Asterolide, 2-Atractylenolide), a major sesquiterpenoids isolated from the dried Rhizome of Atractylodes macrocephala, shows a wide range of biological and pharmacological activities, for example, against insomnia and anxiety, neuroprotective, platelet activation and anti-cancer effect.
S9315 Praeruptorin A Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. Praeruptorin A inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Praeruptorin A can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.
S9316 Polyphyllin II Polyphyllin II, a natural compound extracted from Rhizoma of Paris polyphyllin, shows hemolytic activity.
S9317 Forsythoside A Forsythoside A, one of the main active ingredients in Forsythiae fructus, has been shown to possess anti-bacterial and immunomodulatory properties.
S9318 (20R)-Ginsenoside Rh1 (20R)-Ginsenoside Rh1, isolated from the root of Panax Ginseng, exhibits various pharmacological activities including vasorelaxation, antioxidation, anti-inflammation, and anticancer.
S9319 Cryptochlorogenic acid Cryptochlorogenic acid (4-Caffeoylquinic acid, 4-O-Caffeoylquinic acid), a phenolic acid found in various plant species, including Artemisia, honeysuckle, and H. sabdariffa, possesses antioxidant properties.
S9322 Neodiosmin Neodiosmin (Diosmetin-7-neohesperidoside, Diosmetin-7-O-neohesperidoside), a flavone glycoside isolated from C. aurantium, is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations.
S9324 Alnustone Alnustone, a naturally occuring compound found in the rhizomes of Curcuma xanthorrhiza, exhibits anti-inflammatory, antihepatotoxic and antiemetic activities.
S9329 Orcinol Orcinol (5-Methylresorcinol; 3,5-ToluenediolOrcin; 5-Methyl-1,3-benzenediol; 3,5-Dihydroxytoluene), occurs in many species of lichens including Roccella tinctoria and Lecanora, exhibits antimutagenic, antioxidant, antibacterial, radical-scavenging effects.
S9343 Sequoyitol Sequoia alcohol (Sequoyitol) is isolated from Taxus natural organic compounds, it can be used to treat diabetes and other indications.
S9347 Allitol Allitol (Allodulcitol) is a rare polyol found in nature that is useful not only as a sweetener, but also as the raw material for production of chemical compounds.
S9348 D-(+)-Trehalose Anhydrous Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.
S9350 Ethyl 4-Methoxycinnamate Ethyl 4-Methoxycinnamate (Ethyl p-methoxycinnamate, 4-Methoxycinnamic Acid Ethyl Ester), a natural product found in K. galanga and C. zedoaria extracts, has anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities.
S9354 Oxalic acid Oxalic acid (Ethanedioic acid, Wood bleach) is a strong dicarboxylic acid occurring in many plants and vegetables.
S5636 Methyl furan-2-carboxylate Methyl furan-2-carboxylate (Methyl pyromucate, Methyl 2-furoate) is found in cocoa and cocoa products. It is used in food flavouring and preparation of sesquiterpene lactone.
S3814 Tubeimoside I Tubeimoside I (Lobatoside H, TBMS1), a triterpenoid saponin, isolated from the tubers of Bolbostemma paniculatum, shows potent antitumor and antitumor-promoting effects.
S8068 Chaetocin Chaetocin,一类来自毛壳菌属的天然产物,是一类 histone methyltransferase 抑制剂,其对dSU(VAR)3-9,小鼠G9a和粗糙链孢霉 DIM5的IC50分别为0.8 μM, 2.5 μM和3 μM。Chaetocin是一种抗癌药物并是 thioredoxin reductase (TrxR) 的抑制剂。
S3790 Methyl gallate Methyl Gallate (Methylgallate, Gallic acid methyl ester, Gallicin) is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.
S9188 Magnoflorine chloride Magnoflorine (Escholine, Thalictrine, Corytuberine methochloride), isolated from the rhizome of Sinomenium acutum and from Pachygone ovata, is usually used as an anxiolytic chemical with anti-oxidant, α-tyrosinase inhibitory and anti-inflammationary activities.
S9189 Oroxin A Oroxin A (Baicalein 7-O-glucoside), an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ and inhibits α-glucosidase, exerting antioxidant activity.
S9190 Oroxin B Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.
S9191 Loganic acid Loganic acid (Loganate) is a naturally occurring iridoid monoterpeneglusoside involved in the biosynthesis of indole alkaloids in Vinca rosea.
S9194 Toddalolactone Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM.
S9195 Maltotetraose Maltotetraose, found in many foods, belongs to the class of organic compounds known as oligosaccharides.
S9196 Calceolarioside B Calceolarioside B (Nuomioside A), found in the herbs of Ajuga becumbens Thunb., has anti-proliferation property.
S9199 Pseudoginsenoside F11 Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist.
S9200 Pneumocandin B0 Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent.
S9203 Notopterol Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities.
S9204 Oroxylin A Oroxylin A (6-Methoxybaicalein) is a flavonoid isolated from Scutellaria root that exhibits multiple pharmacological activities, including anti-oxidative, anti-inflammatory, anti-viral and anti-tumor properties.
S9205 Hydroxygenkwanin Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, has anti-oxidant ability and can act as tissue factor (TF) inhibitor to prevent thrombosis.
S9206 Hydroprotopine Hydroprotopine (W1171) is a kind of natural herbal extract.
S9514 Rotundic acid Rotundic acid (Rutundic acid)是一种天然化合物,对人肝细胞癌(HepG2)、恶性黑色素瘤(A375)、SCLC(NCI-H446)、乳腺癌(MCF-7)和结肠癌(HT-29)细胞系表现出细胞毒活性。Rotundic acid 通过调节 AKT/mTOR and MAPK pathways 诱导细胞周期停滞、DNA损伤和细胞凋亡。
S9207 Gypenoside XVII Gypenoside XVII (GP-17, Gynosaponin S), a ginsenoside found in Panax species, has neuroprotective effects and is widely used to prevent cardiovascular disease.
S9208 Ginsenoside Rb3 Ginsenoside Rb3 是从人参中提取的天然产物,在心血管疾病包括心肌的缺血/再灌注(I/R)损伤中起着重要作用。在人肾293T细胞中检测了Ginsenoside Rb3(0.1-10 μM)对肿瘤坏死因子TNF-α诱导的 nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) 荧光素酶报告基因的抑制作用,IC50值为8.2 μM。在用10 ng/mL TNF-α处理后的HepG2细胞中,Ginsenoside Rb3 还以剂量依赖性的方式抑制 cyclooxygenase-2 (COX-2)inducible nitric oxide synthase (iNOS) 信使mRNA的诱导诱导表达。
S9209 Tritetradecanoin Tritetradecanoin, found in Myristica fragrans Houtt., is used as an antiadhesion agent and lubricating agent.
S9210 Ginsenoside Rk1 Ginsenoside Rk1, one of the main elements of Sung Ginseng, has been confirmed as a new endothelial barrier enhancer recently and has anti-cancer activity.
S9211 Eriocitrin Eriocitrin (eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside) is a flavone glycoside mainly found in lemon with antioxidant activity.
S9213 Jujuboside A Jujuboside A, isolated from Semen Ziziphi Spinosae, exerts anti-oxidant, anti-inflammatory activities, and reduces the cell apoptosis.
S9214 Jujuboside B Jujuboside B, one of the saponins isolated from the seeds of Zizyphus jujuba var. spinosa, is used in traditional chinese medicine for treating cardiovascular diseases and neurodegenerative diseases.
S9215 Pinoresinol diglucoside Pinoresinol diglucoside, one of the major lignans isolated from Eucommia ulmoides Oliver bark, has various pharmacological functions, including antihypertension and prevention of osteoporosis.
S9216 Esculentoside A Esculentoside A, isolated from the Chinese herb phytolacca esculenta, possesses a broad inhibitory effect on a panel of pro-inflammation molecules with less toxicity.
S9217 Complanatuside Complanatuside, a flavonoid compound isolated from Astragalus complanatus and Lysimachia christinae, has anti-inflammation, lipid-lowering and hepatoprotective effects.
S9219 Huperzine B Huperzine B, a natural alkaloid existed in Lycopodium plants, is a novel acetylcholinesterase inhibitor and has neuroprotective effects.
S9221 Ferulaldehyde Ferulaldehyde (Coniferaldehyde, Ferulyl aldehyde) is a natural intermediate of polyphenol metabolism of intestinal microflora.
S9222 Dipotassium glycyrrhizinate Dipotassium glycyrrhizinate (Neubormitin) 是从甘草根中分离出来的一种广泛使用的抗炎药。
S9223 Talatisamine Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.
S9224 Dehydroandrographolide Succinate Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.
S9226 Steviolbioside Steviolbioside (CCRIS-6025), a natural sweetener, exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro.
S9228 Schisandrin C Schisandrin C, a dibenzocyclooctadiene lignan isolated from the fruits of Schisandra chinensis (Turcz.) Baill, has many characteristics including anti-inflammation, anti-tumor, and anti-oxidation.
S9229 Linderane Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache.
S9230 Vaccarin Vaccarin, a major flavonoid glycoside found in Semen vaccariae, exhibits extensive biological activities including vascular endothelial cell protective effects.
S9231 Schisanhenol Schisanhenol (Gomisin K3) is a compound derived from the fruit of a traditional Chinese herb Schisandra rubriflora, exhibiting strong inhibition toward UGT2B7.
S9232 Crocin II Crocin II (Crocin B, Crocetin gentiobiosylglucosyl ester, Tricrocin), a carotenoid chemical compound that is found in the flowers crocus and gardenia, is an antioxidant and neural protective agent.
S9233 Imperialine Imperialine (Sipeimine, Kashmirine) is an alkaloid found in the bulbs of species of the genus Fritillaria.
S9234 Schaftoside Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
S9235 Didymin Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.
S9237 Berberrubine Berberrubine (Beroline, 9-Berberoline), an isoquinoline alkaloid isolated from many medicinal plants, possesses diverse pharmacological activities, including glucose-lowering, lipid-lowering, anti-inflammatory, and anti-tumor effects.
S9238 Polygalic acid Polygalic acid (Senegenic acid), a triterpenoid saponin, shows expectorant, emetic and stimulant effects.
S9239 Isocorynoxeine Isocorynoxeine (7-Isocorynoxeine)是一种在钩藤(Uncaria rhynchophylla)中发现的主要生物碱,对心、脑血管系统具有广泛的有益作用。Isocorynoxeine 可抑制 5-HT2A receptor 介导的电流反应,IC50值为72.4 μM。
S9240 Isofraxidin Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
S9242 Narirutin Narirutin (Naringenin-7-O-rutinoside, Isonaringin), a flavanone abundant in citrus fruits, possesses anti-inflammatory and anti-oxidative effects.
S9243 Protosappanin B Protosappanin B (FT-0689654, Q-100961), extracted from Lignum Sappan, possesses anti-inflammation and anti-oxidation properties.
S9244 8-O-acetyl shanzhiside methyl ester 8-O-acetyl shanzhiside methyl ester (Barlerin, ND01), isolated from the leaves of Lamiophlomis rotata Kudo, promotes angiogenesis, which leads to the improvement of functional outcome after stroke.8-O-Acetyl shanzhiside methyl ester can inhibts NF-κB.
S9245 Phellodendrine chloride Phellodendrine chloride, isolated from the Phellodrndron amurensis, exhibits immunosuppressive and anti-inflammatory activities.
S9246 Tiliroside Tiliroside, a glycosidic flavonoid, possesses anti-inflammatory, antioxidant, anticarcinogenic and hepatoprotective activities.
S9247 Isoliensinine Isoliensinine is an alkaloid produced by the edible plant Nelumbo nucifera. It possesses anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.
S9248 Homoorientin Homoorientin (Isoorientin, Luteolin-6-C-glucoside) is a flavone that acts as a radical scavenger and an antineoplastic agent.
S9249 Securinine Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist.
S9250 Isosilybin Isosilybin (Silymarin, Silybin B, Isosilybinin, Q-100795)是一种在水飞蓟(S. marianum)果实提取物中发现的黄烷醇,具有抗氧化和抗癌活性。Isosilybin 抑制 CYP3A4 诱导,IC50为74 μM。
S9251 Oxypeucedanin Oxypeucedanin is a major coumarin aglycone that can be extracted from Ostericum koreanum. It is a kind of open-channel blocker of the hKv1.5 channel.
S9252 Corydaline Corydaline is a bioactive alkaloid with various anti-acetylcholinesterase, anti-allergic, and anti-nociceptive activities found in the medicinal herb Corydalis Tubers.
S9253 Coixol Coixol (6-methoxybenzoxazolone, MBOA) acts as a central muscle relaxant with an anti-convulsant effect.
S9254 Skimmin Skimmin is one of the major pharmacologically active molecules present in Hydrangea paniculata, a medical herb used in the traditional Chinese medicine as an anti-inflammatory agent.
S9255 Isoscopoletin Isoscopoletin (7-Methoxyesculetin) is a member of the class of compounds known as hydroxycoumarins. Isoscopoletin can be found in coriander and eggplant, which makes isoscopoletin a potential biomarker for the consumption of these food products.
S9256 Isobavachin Isobavachin is a flavonoid compound obtained from Psoralea Corylifolia Linn.
S9257 Acetylshikonin Acetylshikonin is a biologically active compound with anti-cancer and anti-inflammatory activity, which is isolated from the roots of Lithospermum erythrorhizoma. It is a novel general P450 inhibitor with IC50 values of 1.4-4.0 μM for all tested P450s.
S9258 (+)-Isocorynoline Isocorynoxeine, a major bioactive tetracyclic oxindole alkaloids found in Uncaria rhynchophylla, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM and shows various beneficial effects, including lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage.
S9260 Nodakenin Nodakenin ((+)-Marmesinin), a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM.
S9265 7-Epitaxol 7-Epitaxol (7-Epipaclitaxel) is the major derivative of taxol found in cells. Taxol (paclitaxel) is a well-known natural-source cancer drug.
S9266 Ginsenoside Rc Ginsenoside Rc, isolated from Panax ginseng, may exert various activities including anti-cancer, anti-inflammatory, antiobesity, and anti-diabetic effects.
S9186 Liensinine perchlorate Liensinine is the active constituent of plumula nelambinis with anti-hypertension.
S9187 Phillygenin Phillygenin (Sylvatesmin), a bioactive intergradient in Osmanthus fragrans, has anti-inflammatory, anti-obesity and antipyretic activities. It could reduce blood lipid levels and low density lipoprotein.
S9517 Liriope muscari baily saponins C Liriope muscari baily saponins C, extracted from the roots of Liriope muscari (Decne.) Baily, induces autophagy and has an anti-thrombotic activity.
S9201 Levistilide A Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.
S9512 1,3-Dicaffeoylquinic acid 1,3-Dicaffeoylquinic acid (Cynarin; Cinarine; 1,5-Dicaffeoylquinic acid) is a phenolic compound found in artichoke. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
S9114 Polyphyllin I Polyphyllin I 是从巴黎茶树素中提取的小分子单体,用于治疗传染病和癌症。 Polyphyllin I 抑制U251细胞增殖并诱导其凋亡。 Polyphyllin I 是 JNK 信号传导途径的激活剂,具有潜在的抗神经胶质瘤作用。
S9115 Wogonoside Wogonoside (Oroxindin, Wogonin 7-O-glucuronide, Glychionide B), the main flavonoid component derived from the root of Scutellaria baicalensis Georgi, displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities.
S9116 Chikusetsusaponin IVa Chikusetsusaponin IVa (Calenduloside F) 是三萜类皂苷的主要活性成分,具有多种药理活性,包括对各种癌细胞的细胞毒活性,抗炎活性,预防龋齿和诱导人五味子霉素肾毒性。Chikusetsusaponin IVa 也是一种新型的 AMPK 激活剂。
S9117 (20S)Ginsenoside Rg2 (20S)Ginsenoside Rg2, a constituent existing in red ginseng, has been reported to exert strong inhibitory action on various cancer cells.
S9119 Leonuride Leonuride (Ajugol), an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri, is a terpene glycoside that can be used for some gynecological disease.
S9121 Irigenin Irigenin, an O-methylated isoflavone, can be isolated from the rhizomes of the leopard lily (Belamcanda chinensis), and Iris kemaonensis.
S9122 Tectorigenin
S9123 Eriodictyol Eriodictyol, a flavonoid extracted from yerba santa, has anti-inflammatory and antioxidant activities and taste-modifying properties.
S9125 Apigetrin Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties.
S9126 Schizandrol B Schizandrol B (Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin), extracted from the fruit of Schisandra chinensis Baill., exhibits potent antitumor activities.
S9127 Carnosol Carnosol is a naturally occurring phenolic diterpene found in rosemary. It has anti-oxidant, anti-inflammatory and anti-cancer activities.
S9128 Isoacteoside Isoacteoside, a phenylethanoid isolated from Monochasma savatieri Franch. ex Maxim., is an anti‐inflammatory herb widely used in traditional Chinese medicine.
S9129 20(S)-Ginsenoside Rh1 20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1)是从红参中提取的主要生物活性化合物之一,在世界范围内,红参已越来越多地用于增强认知和身体健康。它具有抗发炎、抗氧化、免疫调节作用和对神经系统有积极作用的有效特性。20(S)-Ginsenoside Rh1 可抑制 PPAR-γTNF-αIL-6IL-1β 的表达。
S9130 Rubusoside Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.
S9131 Punicalagin Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.
S9132 Harpagide Harpagide, isolated from the secondary roots of Harpagophytum procumbens (Hp), has valuable medicinal properties, such as anti-inflammatory, analgesic and potential antirheumatic effects.
S9133 Chicoric acid Chicoric acid (Dicaffeoyltartaric acid), identified in many plants, exerts various properties include anti-cancer, anti-obesity, antiviral, and anti-diabetic effects.
S9134 Spinosin Spinosin (Flavoayamenin), a flavone-C-glycoside, is a bioactive ingredient isolated from a traditional Chinese herb Zizyphi Spinosi Semen. It acts as a plant metabolite and an anxiolytic drug.
S9135 Artemisic acid Artemisic acid (Artemisinic acid), an amorphane sesquiterpene isolated from Artemisia annua L., has a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect.
S9136 Neochlorogenic acid Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
S9137 Erianin Erianin, a natural product derived from Dendrobium chrysotoxum, has been used as an analgesic in traditional Chinese medicine and is a potential anti-tumor agent. Erianin can inhibit IDO-induced tumor angiogenesis.
S9138 Picfeltarraenin IA Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.
S9141 Berbamine Berbamine (BA, BBM) 是一种从中草药黄芦木中分离而来的双苄基异喹啉类天然产物。它是bcr/abl的新型抑制剂,具有有效的抗白血病活性,是NF-κB的抑制剂。Berbamine (BA, BBM) 通过靶向 Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) 抑制癌细胞的生长,并诱导人骨髓瘤细胞凋亡。
S9143 Ammonium Glycyrrhizate Ammonium glycyrrhizate (Glycamil, Glycyrram) is an ammonium salt extract isolated from licorice root and is commonly used as a flavoring agent and is also used in fragrances, and skin and hair care products.
S9144 Solasonine Solasonine, a natural glycoalkaloid compound, has anti-inflammation and anti-tumor properties.
S9145 Solamargine Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.
S9146 Anwuligan Anwuligan (Macelignan), a natural compound isolated from Myristica fragrans Houtt, has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities.
S9148 Peiminine Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth.
S9149 Benzoylpaeoniflorin Benzoylpaeoniflorin, a natural product isolated from Chinese paeony root, could inhibit COX-1 and COX-2 in vitro.
S9150 Daurisoline Daurisoline, a bis-benzylisoquinoline alkaloid isolated from the rhizomes of Menispermum dauricum, is a potent autophagy blockers with antiarrhythmic effects.
S9151 Praeruptorin E Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect.
S9152 Epiberberine Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean).
S9153 Betulinicaldehyde Betulinicaldehyde (Betulinal, Betunal), isolated from the bark of tectona grandis., is an anti-tumor agent.
S9154 Chelidonine Chelidonine (Stylophorin, Helidonine), a major bioactive, isoquinoline alkaloid ingredient in Chelidonium majus, exhibits anti-inflammatory properties and acetylcholinesterase and butyrylcholinesterase inhibitory activity.
S9155 Aurantio-obtusin Aurantio-obtusin is a natural effective compound isolated from Semen Cassiae, which possesses hypotensive and hypolipidemic effects.
S9156 Chonglou Saponin VII Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
S9157 Neoandrographolide Neoandrographolide, a principle diterpenoids isolated from A. paniculata, exerts a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.
S9159 momordin-Ic Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo.
S5742 Deferoxamine mesylate (Ba 33112) Deferoxamine mesylate (Ba 33112, Desferrioxamine B, DFOM, NSC 644468)是Deferoxamine的甲磺酸盐,它可形成铁络合物并用作螯合剂。Deferoxamine 是一种铁死亡的抑制剂,可在体外低氧和高血糖状态下稳定 HIF-1α 的表达并改善HIF-1α的活性。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉积并诱导自噬。
S9160 Ziyu-glycoside I Ziyuglycoside I is one of the major active ingredients in Sanguisorba officinalis and could be used as an active ingredient for cosmetics.
S9161 Ziyuglycoside II Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties.
S9162 Rubimaillin Rubimaillin (Mollugin), found in the Chinese medical plant Rubia cordifola, is a dual inhibitor of acetyl-CoA cholesterol acyltransferase 1 (ACAT1) and acetyl-CoA cholesterol acyltransferase 2 (ACAT2), but is more selective for the ACAT2 isozyme.
S9163 Rhapontigenin Rhapontigenin (Protigenin), produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation, is a selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM).
S9164 Curdione Curdione, one of the major components of Curcuma zedoaria, shows an excellent antithrombotic activity in vivo.
S9165 Poncirin Poncirin (Isosakuranetin-7-neohesperidoside), extracted from trifoliate orange, has anti-bacterial and anti-inflammatory activities.
S9167 Columbin Columbin, a diterpenoid furanolactone, is a potential anti-inflammatory drug.
S9168 Periplogenin Periplogenin (Desoxostrophanthidin, 5-beta-Hydroxydigitoxigenin), isolated from Lagenaria siceraria, has potent anti-psoriatic effects in vitro and in vivo.
S9171 Harpagoside Harpagoside, a natural product found in the plant Harpagophytum procumbens, has potent anti-rheumatic, anti-inflammatory and analgesic effects.
S9172 Phellodendrine Phellodendrine, a quaternary ammonium alkaloid extracted from the dried bark of Phellodendrom chinensis Schneid and Phellodendrom amurense Rupr, has the effect of suppressing cellular immune response, reducing blood pressure and antinephritis.
S9173 Sec-O-Glucosylhamaudol Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) is one of the major bioactive compounds of the Saposhnikoviae Radix.
S9174 Xanthotoxol Xanthotoxol (8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen), a biologically active linear furocoumarin found in a large number of plants, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.
S9175 Macranthoidin A Macranthoidin A, found in the herbs of Lonicera japonica Thunb., has anti-inflammation activity.
S9176 Pimpinellin Pimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity.
S9177 Gypenoside XLIX Gypenoside XLIX, a naturally occurring gynosaponin, is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator.
S9178 Sinapine thiocyanate Sinapine thiocyanate is the thiocyanate salt form of Sinapine, which shows favorable biological activities such as antioxidant and radio-protective activities.
S9179 Catharanthine hemitartrate Catharanthine hemitartrate is the starting material for the synthesis of the antitumor drugs vinblastine and vincristine.
S9180 Tussilagone Tussilagone, isolated from the flower of buds of Tussilago farfara (Compositae), is a sesquiterpenoid that is used as a traditional oriental medicine for asthma and bronchitis. It shows anti-inflammatory activity in in vitro studies.
S9181 Periplocin Periplocin (Periplocoside)是从传统草药皮质骨膜中提取的,具有心脏和抗癌活性。Periplocin 可以显著地促进成纤维细胞L929细胞的增殖、迁移和刺激胶原蛋白的产生,这取决于 Na/K-ATPase 介导的Src/ERK和PI3K/Akt信号通路的激活,从而促进伤口愈合 。
S9182 Crebanine Crebanine, an aporphine alkaloid isolated from the crude hexane extract of the dried tuber of Stephania venosa, exhibits anti-cancer effects.
S9183 Ruscogenin Ruscogenin, a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been reported to exert significant anti-inflammatory and anti-thrombotic activities.
S9184 Forsythoside B Forsythoside B 是从中药民间植物轮枝(Lamiophlomis rotata Kudo)的叶子中分离出来的一种苯乙胺类苷。Forsythoside B 具有有效的神经保护作用,并具有抗发炎、抗氧化和防腐特性。Forsythoside B 可以抑制 TNF-alphaIL-6IκB 并调节 NF-κB
S9185 Nitidine Chloride Nitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity.
S9455 Isorhamnetin 3-O-neohesperoside Isorhamnetin 3-O-neohesperoside is the major active substance of Puhuang, a traditional herb medicine widely used in clinical practice to tackle many chronic diseases. It has significant biological and pharmacological activities, including antioxidant, antiatherogenic and antimicrobial effects.
S9511 Crocin I Crocin-I是藏红花素家族的主要成员之一,具有抗抑郁活性,并可改善慢性皮质酮诱导的小鼠脂质代谢破坏和肠道菌群失调。
S9515 Polyphyllin VII Polyphyllin VII (Y-0166), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocellular carcinoma and osteosarcoma.
S5129 D-Aspartic acid D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).
S9055 Salvianolic acid A Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.
S9052 Auraptene Auraptene (7-geranyloxycoumarin)是源自柑橘类植物的天然香豆素,具有重要的药理特性,包括抗癌,抗炎,抗幽门螺杆菌,抗原毒性和神经保护作用。Auraptene 可抑制 matrix metalloproteinase 2 (MMP-2) 以及关键的炎症介质,包括 IL-6IL-8chemokine (C-C motif) ligand-5(CCL5)
S9045 Triptophenolide Triptophenolide (Hypolide), derived from Tripterygium wilfordii, is a pan-antagonist for wild-type and mutant androgen receptors with the IC50 values of 260 nM for AR-WT, 480 nM for AR-F876L, 388 nM for AR-T877A, and 437 nM for W741C+T877A.
S9061 Hydroxy safflor yellow A Hydroxy safflor yellow A, a monomer extracted from Carthamus tinctorius L., possesses various kinds of bio-activities, including anti-oxidation, anti-inflammatory actions, anti-platelet aggregation, anti-tumor and anti-myocardial injury effects.
S9062 4-Hydroxyisoleucine 4-Hydroxyisoleucine, an atypical branched-chain amino acid derived from fenugreek, has effects on the glucose and lipid metabolism, stimulates glucose-dependent insulin secretion and reduces insulin resistance in muscle and/or liver.
S9063 Harringtonine Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.
S9064 Trilobatin Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect.
S9065 Songorine Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.
S9066 Specnuezhenide Specnuezhenide (Nuezhenide), one of the main ingredients of Chinese medicine, has anti-angiogenic and vision improvement effects.
S9067 Pseudoprotodioscin Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
S9068 Trillin Trillin (Disogluside, Diosgenin glucoside) is an active ingredient isolated from Trillium tschonoshii Maxim and acts as a potential anti-inflammatory drug for chronic hepatic inflammation.
S9069 Jatrorrhizine chloride Jatrorrhizine chloride (Neprotine, Yatrorhizine) is the hydrochloride salt form of jatrorrhizine, which is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
S9070 Isoxanthohumol Isoxanthohumol is one of the most important prenylflavonoids found in hops. It exhibits an antiproliferative activity against human breast cancer cell lines, ovarian cancer, prostate cancer, and colon cancer cells. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).
S9072 Sweroside Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.
S9073 Lithospermoside Lithospermoside (Griffonin), extracted from the roots of Lithospermum purpurocaeruleum and L.officinale (Borginaceae), and Thalictrum rugosum and T. dasycarpum (Ranunculaceae), has anti-oxidant, anti-tumor promoting activities.
S9074 Buddlejasaponin IVb Buddlejasaponin IVb (Saikosaponin 1b), a major component of Pleurospermum kamtschaticum, exerts anti-inflammatory and cytotoxic effects against cancer cells.
S9075 Mulberroside A Mulberroside A 是从 Morus alba 根的乙醇提取物中分离出的,具有抗酪氨酸酶和抗氧化活性,并被广泛用作化妆品中的活性成分。Mulberroside A 降低 TNF-αIL-1βIL-6 的表达并抑制 NALP3caspase-1NF-κB 的激活以及 ERKJNKp38 的磷酸化。
S9076 Typhaneoside Typhaneoside is a flavonoid glycoside plant extract that has an inhibitory effect on the proliferation of human umbilical arterial smooth muscle cell(HUASMC).
S9077 Plantamajoside Plantamajoside (Y0160, C10485), a hydroxycinnamic acid, is used as a biomarker in chemotaxonomical studies, and is a compound with numerous biological applications and considerable pharmacological potential.
S9078 Epigoitrin Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities.
S9079 Ginsenoside Rb2 Ginsenoside Rb2 (Ginsenoside C) is a ginsenoside found in Panax ginseng that has a role as a plant metabolite, an antiviral agent and a hypoglycemic agent.
S9080 Anhydroicaritin Anhydroicaritin (Cycloicaritin), a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs.
S9081 Anemoside B4 Anemoside B4 (Pulchinenoside B4, Chinensioside A, Pulchinenoside C, Pulsatilla saponin B4), extracted from the herb of Pulsatilla chinensis (Bge.) Regel, is a potential antiviral constituent and inhibits the secretion of IL-10.
S9082 Manninotriose Manninotriose, found in many foods, is a novel and important player in the RFO metabolism of red dead deadnettle.
S9083 Rhapontin Rhapontin (Ponticin, Rhaponticin, Rhapontigenin glucoside), a stibene-type glycoside distributed widely in medicinal plants of Rheum genus (Polygonaceae), has anti-inflammatory effect and anti-proliferative activity.
S9084 Rhoifolin Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.
S9085 Corynoline Corynoline is one of the major active components of many ethnopharmacological plants and exhibits anti-tumor, anti-inflammatory and hepatoprotective activities, etc.
S9111 Isorhamnetin Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.
S9112 Kaempferitrin Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.
S9113 Ononin Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects.
S9101 Ingenol Ingenol, a plant-derived diterpenoid, is a weak PKC activator and possesses important anticancer activity.
S9019 Quillaic acid Quillaic acid is the major aglycone of the widely studied saponins of the Chilean indigenous tree Quillaja saponaria Mol and shows strong anti-inflammatory activity.
S9020 Dihydrotanshinone I Dihydrotanshinone I (15,16-dihydrotanshinone I) is a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, also known as Chinese sage, red sage root, and the Chinese herbal Dan Shen. It is a potent inhibitor of the HuR:RNA interaction, active in the low nanomolar range, mainly by limiting the association rate of HuR with RNA.
S9021 (20R)Ginsenoside Rg3 (20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.
S9022 20S-Ginsenoside Rg3 20S-Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It exihits neuromodulatory, cognition enhancing, anti-inflammatory, antioxidative, anti-angiogenic, and anticancer activities.
S9023 20S-Ginsenoside Rh2 20S-Ginsenoside Rh2 is a ginsenoside found in Panax species and inhibits cancer development, progression, and metastasis.
S9026 Hastatoside Cimifugin is a bioactive component of Saposhnikovia divaricata, a Chinese herb for treating allergy.
S9029 Prim-o-glucosylcimifugin Prim-O-glucosylcimifugin (Cimifugin beta-D-glucopyranoside, Cimifugin 7-glucoside) 是防风(Radix Saposhnikovia)中的主要成分,长期以来一直应用于传统中医药中治疗发热、风湿和癌症,它表现出潜在的抗癌活性。在LPS激活的 RAW 264.7 巨噬细胞,Prim-O-glucosylcimifugin 可以浓度依赖性的方式下调 NO synthase (iNOS)cyclooxygenase 2 (COX-2) 的mRNA和蛋白质表达。
S9031 Gambogenic acid Gambogenic Acid, identified from Gamboge, is an inhibitor of the FGFR signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects. Gambogenic acid acts is also an effective inhibitor of EZH2 that specifically and covalently binds to Cys668 within the EZH2-SET domain, and triggers EZH2 ubiquitination.
S9034 Isochlorogenic acid C Isochlorogenic acid C (3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid), which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.
S9039 Albiflorin Albiflorin, a natural product isolated from Paeoniae Radix, is a novel 5-HT and NE reuptake inhibitor with high selectivity.
S9040 Maslinic acid Maslinic Acid (Crategolic Acid, 2α-Hydroxyoleanoic Acid), a Natural Triterpene, exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. MA significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells.
S9054 Pectolinarin Pectolinarin 是Cirsium setidens的一种主要化合物,具有抗炎活性。Pectolinarin 可抑制 IL-6IL-8 的分泌以及 PGE2NO 的产生。Pectolinarin 通过 PI3K/Akt 信号通路的失活来诱导凋亡。
S9050 Boldine Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
S9049 Parishin A Parishin A, isolated from the rhizomes of Gastrodia elata, has good neuroprotective effects against brain disorders.
S9060 Nystose Nystose (1,1-Kestotetraose, Fungitetraose), a constituent of seeds of onions and roots of Asparagus, is a low-calorie sweetening agent for food and chewing gum.
S9092 Norisoboldine Norisoboldine (Laurelliptine), a natural aryl hydrocarbon receptor (AhR) agonist, attenuates ulcerative colitis (UC) and induces the generation of Treg cells.
S9093 Nardosinone Nardosinone, isolated from Nardostachys root, an important Chinese herbal medicine, is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities.
S9097 Alisol B Acetate Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.
S9098 Dehydrodiisoeugenol Dehydrodiisoeugenol, a naturally occurring lignan from Aristolochia taliscana (Aristolochiaceae), acts as a potent anti-inflammatory agent and shows various pharmacological activities, including anti-lipid peroxidation, anti-bacteial function, and hepatic drug metabolism enzyme inhibition.
S9099 Orientin Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.
S9100 Fraxinellone Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities.
S9102 Magnolin Magnolin is a natural compound abundantly found in Magnolia flos targeting ERK1 (IC50=87 nM) and ERK2 (IC50=16.5 nM) and inhibits cell transformation induced by tumor promoters such as epidermal growth factor (EGF).
S9103 Ginsenoside Ro Ginsenoside Ro (Chikusetsusaponin V), one of the high-abundance saponins in ginseng, is widely used as a dietary supplement and has many health-promoting effects.
S9104 Maltopentaose Maltopentaose is a substrate for energy metabolism and carbon for E. coli.
S9105 Ginsenoside CK Ginsenoside CK is a ginsenoside found in Panax species and has a role as a plant metabolite, an antineoplastic agent, a hepatoprotective agent, an anti-allergic agent and an anti-inflammatory agent.
S9108 Timosaponin A3 Timosaponin A3 (Filiferin B, AneMarsaponin A3), one of the major steroidal saponin components isolated from Anemarrhena asphodeloides, displays promising pharmacological activity in improving learning, memory, and antineoplastic activity.
S9056 Tuberostemonine Tuberostemonine, a natural product found in Stemona phyllantha and Stemona tuberosa, is an alkaloid and a metabolite.
S9053 Irisflorentin Irisflorentin derived from the roots of Belamcanda chinensis (L.) DC. is an herb which has been used for the treatment of inflammatory disorders in traditional Chinese medicine.
S9051 Asperuloside Asperuloside, an iridoid glycoside found in Herba Paederiae, is a component from traditional Chinese herbal medicine and exerts anti-inflammatory effect.
S9048 (+)-Gallocatechin (+)-Gallocatechin, found notably in green tea, has moderate affinity to the human cannabinoid receptor and acts as an antioxidant.
S9057 Sinigrin Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.
S9058 Gallocatechin gallate Gallocatechin galleate (GCG) is a polyphenol originally derived from a variety of sources, including green tea, coffee, safflower, and almonds.
S9086 Dihydrocapsaicin Dihydrocapsaicin (6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589), found in pepper (C. annuum), is a potential nutriceutical.
S9088 Calycosin-7-O-beta-D-glucoside Calycosin-7-O-beta-D-glucoside, an isoflavone glycoside isolated from A. mongholicus and A. membranaceus, has antioxidant, anti-inflammatory, and neuroprotective biological activities.
S9089 Magnoflorine Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.
S9090 Corilagin Corilagin, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. It is an inhibitor of TNF-α.
S9091 10-Gingerol 10-Gingerol is a bioactive compound found in ginger with anti-inflammatory and antioxidant activity.
S9095 Senegenin Senegenin (Tenuigenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory activity.
S9096 ligustroflavone Ligustroflavone (Nuezhenoside), isolated from the leaves of Turpinia montana, shows high antioxidant capacity and is reported to be an AMPK activator.
S9106 Eleutheroside E Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.
S9107 Glycitein Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.
S9109 1-Kestose 1-Kestose (1F-beta-D-Fructosylsucrose), a fructooligosaccharide, could efficiently stimulates Faecalibacterium prausnitzii as well as Bifidobacteria in humans.
S9110 Morin Morin (Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum), a constituent of various woods, has a role as an antioxidant, a metabolite, an antihypertensive agent, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an antineoplastic agent, an antibacterial agent, a DNA topoisomerase inhibitor and an angiogenesis modulating agent.
S4700 4-Aminobutyric acid (GABA) 4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid)是一种天然存在的神经递质,具有抑制中枢神经系统的活性。
S5580 Arabic gum Arabic gum, derived from exudates of Acacia senegal or Acacia seyal trees, is a complex polysaccharide indigestible to both humans and animals and considered as a safe dietary fiber.
S3774 Dehydroandrographolide Succinate Potasium Salt Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.
S9008 20-Deoxyingenol 20-Deoxyingenol is a natural compound isolated from the seeds of Euphorbia lathyris L.
S5145 Protoporphyrin IX Protoporphyrin IX (PPIX) is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway.
S5288 Estropipate Estropipate (Piperazine estrone sulfate, Estrone sulfate piperazine salt, Pipestrone) is a natural estrogenic substance composed of estrone sulfate and piperazine and is used mainly in menopausal hormone therapy in the treatment of menopausal symptoms.
S3917 Tetrahydrocurcumin Tetrahydrocurcumin (Tetrahydrodiferuloylmethane, Tetrahydro Curcumin), a major metabolite of curcumin, possesses strong antioxidant and cardioprotective properties.
S5675 Yamogenin Yamogenin, a sapogenin found in fenugreek, inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes.
S5373 Pseudolaric Acid B Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties.
S5676 Zearalenone Zearalenone (F2 toxin, RAL) is a non-steroidal estrogenic mycotoxin that acts by binding the estrogen receptor (ER).
S5678 trans-Zeatin-riboside Zeatin Riboside is the most active and ubiquitous form of the naturally occurring cytokinins that promote cell division, stimulate shoot proliferation, inhibit root formation, slow the aging process, and activate gene expression and metabolic activity.
S5705 Raceanisodamine Raceanisodamine (7β-Hydroxyhyoscyamine) is the active ingredient of Chinese herbal extracts that has vasoactive activity used to treat acute disseminated intravascular coagulation in patients in bacteremic shock.
S3843 Madecassoside Madecassoside (Asiaticoside A)是积雪草草药的主要活性三萜烯成分,积雪草是一种传统中药,用于治疗创伤修复和疤痕管理。
S5560 Midecamycin Midecamycin (Espinomycin A, Medecamycin A1, Platenomycin B1, Rubimycin, Turimycin P3) is a naturally occuring macrolide antibiotic that acts by inhibiting bacterial protein synthesis.
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