2',3'-cGAMP Sodium Salt

For research use only. Not for use in humans.

目录号:S7904 别名: 2'-3'-cyclic GMP-AMP Sodium, 2',3'-cGAMP Sodium

2',3'-cGAMP Sodium Salt Chemical Structure

CAS No. 1441190-66-4 (free acid)

2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium)是响应哺乳动物细胞质中的DNA产生的,并能以高亲和力结合 STING,且有效地诱导 interferon-β (IFNβ)。2',3'-cGAMP 结合 STING 的Kd值为3.79 nM。

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产品安全说明书

STING抑制剂选择性比较

生物活性

产品描述 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium)是响应哺乳动物细胞质中的DNA产生的,并能以高亲和力结合 STING,且有效地诱导 interferon-β (IFNβ)。2',3'-cGAMP 结合 STING 的Kd值为3.79 nM。
靶点
STING [1]
(Cell-free assay)
3.79 nM(Kd)
体外研究

2',3'-cGAMP is an endogenous second messenger produced by mammalian cells. 2',3'-cGAMP is a high affinity ligand for STING. 2',3'-cGAMP is a potent inducer of type-I interferons. 2',3'-cGAMP binding induces conformational changes of STING.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
293T M17zOmZ2dmO2aX;uJIF{e2G7 M{LBc|MxKG2rboO= M1W3NWFkfGm4YYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iU2TJUmchcGGybH;0fZBmKFJ5MVivS|I{OEFxUkK5N3EhdXW2YX70JIV5eHKnc4Pl[EBqdiB{OUPUJINmdGy|IH3lZZN2emWmIHHmeIVzKDNyIH3pcpMhcW5icILld4Vv[2Vib3[g[IlocXSxbnnuJGEh[nliYoLp[4h1KEeubz3seYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUCgQUAxNjB{IN88UU4> NIPwN4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUexOVA6QSd-M{G3NVUxQTl:L3G+
293T M1P3VWZ2dmO2aX;uJIF{e2G7 M2XEWFMxKG2rboO= NGO3U5RC[3SrdnH0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIIfpcIQufHmyZTDTWGlPTyCneIDy[ZN{\WRiaX6gNlk{XCClZXzsd{Bu\WG|dYLl[EBi\nSncjCzNEBucW6|IHnuJJBz\XOnbnPlJI9nKGSrZ3n0c45qdiCDIHL5JIJzcWeqdDDHcI8udHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxKD1iMD6wNkDPxE1w NHOwWnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUexOVA6QSd-M{G3NVUxQTl:L3G+
293T MY\GeY5kfGmxbjDhd5NigQ>? NIXlW4U{OCCvaX7z M{PVSmFkfGm4YYTpc44hd2ZicnXjc41jcW6jboSgbJVu[W5iU2TJUmchcGGybH;0fZBmKEd{M{DBM3IzQTOTIH31eIFvfCCneIDy[ZN{\WRiaX6gNlk{XCClZXzsd{Bu\WG|dYLl[EBi\nSncjCzNEBucW6|IHnuJJBz\XOnbnPlJI9nKGSrZ3n0c45qdiCDIHL5JIJzcWeqdDDHcI8udHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxKD1iMD6wOEDPxE1w MkSzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF5MUWwPVkoRjNzN{G1NFk6RC:jPh?=
293T NUSz[3JOTnWwY4Tpc44h[XO|YYm= MkfkN|AhdWmwcx?= MlvIRYN1cX[jdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCVVFnOS{Bp[XCub4T5dIUhWjJ7M2GgcZV1[W62IHX4dJJme3OnZDDpckAzQTOWIHPlcIx{KG2nYYP1doVlKGGodHXyJFMxKG2rboOgbY4heHKnc3XuZ4Uhd2ZiZHnnbZRwdmmwIFGgZpkh[nKrZ3j0JGdtdy2udXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTBiPTCwMlA2KM7:TT6= NEjtb2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUexOVA6QSd-M{G3NVUxQTl:L3G+
293T Ml[wSpVv[3Srb36gZZN{[Xl? NYi1SWM4OzBibXnudy=> NGP1WWpC[3SrdnH0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIGPUTW5IKGijcHzveJlx\SCUMkOyTEBufXSjboSg[ZhxemW|c3XkJIlvKDJ7M2SgZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhOzBibXnud{BqdiCycnXz[Y5k\SCxZjDkbYdqfG:waX6gRUBjgSCkcnnnbJQhT2yxLXz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3MDC9JFAvODdizszNMi=> NXrJbWdDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G3NVUxQTlpPkOxO|E2ODl7PD;hQi=>
293T M4HhfmZ2dmO2aX;uJIF{e2G7 MnjhO{BpenN? NFHBZ|JC[3SrdnH0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIIfpcIQufHmyZTDTWGlPTyCneIDy[ZN{\WRiaX6gNlk{XCClZXzsd{BqdmO3YnH0[YQh\m:{IEegbJJ{KGmwIHHid4Vv[2Vib3[g[IlocXSxbnnuJGEh[nliYoLp[4h1KEeubz3seYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUCgQUAyOy55IN88UU4> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTdzNUC5PUc,OzF5MUWwPVk9N2F-
THP1 MUjGeY5kfGmxbjDhd5NigQ>? M4SzelIxKGi{cx?= NVjWZYh[SWexbnnzeEBi[3Srdnn0fUBifCCVVFnOS{BqdiCqdX3hckBVUFBzIHPlcIx{KGG|c3Xzd4VlKGG|IIP0bY12dGG2aX;uJI9nKEmURkOgdIF1cHejeTDt[YF{fXKnZDDh[pRmeiB{MDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyIE2gN|gvPiEQvF2u MmHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF6MkC5PFUoRjNzOEKwPVg2RC:jPh?=
PBMC NX;XSHpoTnWwY4Tpc44h[XO|YYm= M4fnTlY6NjZidV2= MmrZOEBpenN? NFzmVoJC\2:waYP0JIFkfGm4aYT5JIF1KFOWSV7HJIlvKGi3bXHuJHBDVUNiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gR3hEVDFyIH3SUmEhdGW4ZXygZZQhPjlwNjD1UUBu\WG|dYLl[EBi\nSncjC0JIhzeyCkeTDxVnQuWEOUIHHuZYx6e2m| MkSyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF6MkC5PFUoRjNzOEKwPVg2RC:jPh?=
PBMC M3PTV2Z2dmO2aX;uJIF{e2G7 NGTZWVQyNjN7IITvJFE{QSC3TR?= NYfMO|B{PCCqcoO= Ml7NRYdwdmm|dDDhZ5Rqfmm2eTDheEBUXEmQRzDpckBpfW2jbjDQRm1EKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFnGUoJmfGFicnXs[YF{\SCjdDCxMlM6KHSxIEGzPUB2VSCvZXHzeZJm\CCjZoTldkA1KGi{czDifUBGVEmVQR?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTh{MEm4OUc,OzF6MkC5PFU9N2F-
PBMC MkjTSpVv[3Srb36gZZN{[Xl? NWSxVHNUPjlwNjD1US=> Ml;6OEBpenN? MkPyRYdwdmm|dDDhZ5Rqfmm2eTDheEBUXEmQRzDpckBpfW2jbjDQRm1EKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFnGUoJmfGFibWLORUBt\X[nbDDheEA3QS54IIXNJI1m[XO3cnXkJIFnfGW{IESgbJJ{KGK7IIHSWE1RS1JiYX7hcJl{cXN? NXXOendpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G4NlA6QDVpPkOxPFIxQTh3PD;hQi=>
PBMC NX\hTHUxTnWwY4Tpc44h[XO|YYm= NVfZUFZOPjlwNjD1US=> MWS0JIhzew>? MYTB[49vcXO2IHHjeIl3cXS7IHH0JHNVUU6JIHnuJIh2dWGwIGDCUWMh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iSVy2JI1TVkFibHX2[Ywh[XRiNkmuOkB2VSCvZXHzeZJm\CCjZoTldkA1KGi{czDifUByWlRvUFPSJIFv[Wy7c3nz NWTSTHR6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G4NlA6QDVpPkOxPFIxQTh3PD;hQi=>
PBMC MnHWSpVv[3Srb36gZZN{[Xl? MYSxN|khfU1? NV;aR5dsPCCqcoO= MXzB[49vcXO2IHHjeIl3cXS7IHH0JHNVUU6JIHnuJIh2dWGwIGDCUWMh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iSVy2JJBzd2S3Y4Tpc44h[XRiMUO5JJVOKG2nYYP1doVlKGGodHXyJFQhcHK|IHL5JGVNUVOD M2[3W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzOEKwPVg2Lz5|MUiyNFk5PTxxYU6=
B16-OVA M4CyWWFvfGm2dX3vdkBie3OjeR?= MWDBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEMU[tU3ZCKGOnbHzzJIlueGyjboTl[EBqdiCvb4Xz[UBie3Onc4Pl[EBieyC2dX3veZIhemWpcnXzd4lwdiCrbjDpcopm[3SnZDDmcIFvcyCjdDCxNEB2\yCjZH3pcol{fGW{ZXSgbY51emG2dX3vdoFtdHlib36g[IF6KDZuIEmgZY5lKDF{IIDvd5QhcW2ybHHueIF1cW:w M3P3N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUCwPVk3Lz5|MUWwNFk6PjxxYU6=
B16-OVA MlK2RY51cXS3bX;yJIF{e2G7 MYLBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEMU[tU3ZCKGOnbHzzJIlueGyjboTl[EBqdiCvb4Xz[UBie3Onc4Pl[EBieyC2dX3veZIhemWpcnXzd4lwdiCrbjDjc451emGuYYTldoFtKG[uYX7rJIF1KDFyIIXnJIFldWmwaYP0[ZJm\CCrboTyZZR2dW:{YXzsfUBwdiCmYYmgOkwhQSCjbnSgNVIheG:|dDDpcZBt[W62YYTpc44> Mn3GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3MEC5PVYoRjNzNUCwPVk3RC:jPh?=
B16-OVA NGXOfZVCdnSrdIXtc5Ih[XO|YYm= NY\HfHAySW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhdW:3c3WgRlE3NU:YQTDj[YxteyCrbYDsZY51\WRiaX6gcY92e2ViYYPz[ZN{\WRiYYOgbIlocGW{IH71cYJmeiCxZjDtc5V{\SCldYLl[EBw\iC2dX3vdpMh[XRiMUCgeYch[WSvaX7pd5RmemWmIHnueJJifHWvb4LhcIx6KG:wIHThfUA3NCB7IHHu[EAyOiCyb4P0JIlueGyjboTheIlwdg>? NX;VbGFFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1NFA6QTZpPkOxOVAxQTl4PD;hQi=>

... Click to View More Cell Line Experimental Data

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[2]

- 合并
  • Cell lines: A549, BSC-40, BSR-T7, Vero cells
  • Concentrations: 25 μM, 20 μM, 2.5 μM
  • Incubation Time: 30 min
  • Method:

    A549 cells are infected at an MOI of 5 with WT VACV or VACV-ΔPoxin and lysed 5 hpi. As a positive control, cells are permeabilized for 30 min with digitonin buffer (10 μg ml−1 digitonin, 50 mM HEPES-KOH pH 7.5, 100 mM KCl, 3 mM MgCl2, 0.1 mM DTT, 85 mM sucrose, 0.2% BSA, 1 mM ATP, and 0.1 mM GTP) and stimulated with or without 25 μM 2',3'-cGAMP. After stimulation, the cells are washed once with DMEM supplemented with 10% FBS, media is replaced, and cells are incubated 5 h before lysis.


    (Only for Reference)

溶解度 (25°C)

体外 Water 50 mg/mL (69.6 mM)
DMSO 12.5 mg/mL (17.4 mM)

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 718.37
化学式

C20H22N10Na2O13P2

CAS号 1441190-66-4 (free acid)
储存条件 粉状
溶于溶剂
别名 2'-3'-cyclic GMP-AMP Sodium, 2',3'-cGAMP Sodium

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

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操作手册

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID