2',3'-cGAMP Sodium Salt

别名: 2'-3'-cyclic GMP-AMP Sodium, 2',3'-cGAMP Sodium

2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium)是响应哺乳动物细胞质中的DNA产生的,并能以高亲和力结合 STING,且有效地诱导 interferon-β (IFNβ)。2',3'-cGAMP 结合 STING 的Kd值为3.79 nM。

2',3'-cGAMP Sodium Salt Chemical Structure

2',3'-cGAMP Sodium Salt Chemical Structure

CAS: 1441190-66-4 (free acid)

规格 价格 库存 购买数量
1mg RMB 4170.97 现货
5mg RMB 9582.84 现货
更大包装

400-668-6834

info@selleck.cn

免费分装
免费预溶

产品质控

批次: 纯度: 99.83%
99.83

常与2',3'-cGAMP Sodium Salt一起在实验中被使用的化合物

Canagliflozin (JNJ 28431754)


2',3'-cGAMP和Canagliflozin组合是骨肉瘤的新型疗法。

Wu W, et al. Cell Death Dis. 2022 Jun 3;13(6):523.

Vadimezan (DMXAA)


2',3'-cGAMP和Vadimezan (DMXAA)都能够将M2细胞重新教育为M1表型。

Downey CM, et al. PLoS One. 2014 Jun 18;9(6):e99988.

BV-6


2',3'-cGAMP和BV6共同对PC细胞发挥抗肿瘤作用。

Hannes S, et al. Cell Death Dis. 2021 Aug 30;12(9):816.

3',3'-cGAMP


2',3'-cGAMPSodiumSalt和3',3'-cGAMP均能成熟的人单核细胞来源的DC,上调CD40/CD80/CD86/HLA-DR标记物水平。

Gutjahr A, et al. JCI Insight. 2019 Apr 4; 4(7): e125107.

diABZI STING agonist (Compound 3)


2',3'-cGAMP Sodium Salt和diABZI STING agonist (Compound 3)具有最有效的广谱抗病毒功能。

Jr GG, et al. Cell Rep Med. 2023 May 16;4(5):101024.

2',3'-cGAMP Sodium Salt相关产品

STING抑制剂选择性比较

细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
PBMC Function assay 69.6 uM 4 hrs Agonist activity at STING in human PBMC cells assessed as increase in CXCL10 mRNA level at 69.6 uM measured after 4 hrs by qRT-PCR analysis 31820985
PBMC Function assay 1.39 to 139 uM 4 hrs Agonist activity at STING in human PBMC cells assessed as increase in IFNbeta release at 1.39 to 139 uM measured after 4 hrs by ELISA 31820985
PBMC Function assay 69.6 uM 4 hrs Agonist activity at STING in human PBMC cells assessed as increase in IFNbeta mRNA level at 69.6 uM measured after 4 hrs by qRT-PCR analysis 31820985
PBMC Function assay 69.6 uM 4 hrs Agonist activity at STING in human PBMC cells assessed as increase in IL6 mRNA level at 69.6 uM measured after 4 hrs by qRT-PCR analysis 31820985
PBMC Function assay 139 uM 4 hrs Agonist activity at STING in human PBMC cells assessed as increase in IL6 production at 139 uM measured after 4 hrs by ELISA 31820985
293T Function assay 30 mins Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay, EC50 = 0.02 μM. 31715099
293T Function assay 30 mins Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay, EC50 = 0.02 μM. 31715099
293T Function assay 30 mins Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay, EC50 = 0.04 μM. 31715099
293T Function assay 30 mins Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay, EC50 = 0.05 μM. 31715099
293T Function assay 30 mins Activation of recombinant human STING haplotype R232H mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay, EC50 = 0.07 μM. 31715099
293T Function assay 7 hrs Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase reporter gene assay, EC50 = 13.7 μM. 31715099
THP1 Function assay 20 hrs Agonist activity at STING in human THP1 cells assessed as stimulation of IRF3 pathway measured after 20 hrs by luciferase reporter gene assay, EC50 = 38.6 μM. 31820985
B16-OVA Antitumor assay Antitumor activity against mouse B16-OVA cells implanted in mouse assessed as tumour regression in injected flank at 10 ug administered intratumorally on day 6, 9 and 12 post implantation 31500996
B16-OVA Antitumor assay Antitumor activity against mouse B16-OVA cells implanted in mouse assessed as tumour regression in contralateral flank at 10 ug administered intratumorally on day 6, 9 and 12 post implantation 31500996
B16-OVA Antitumor assay Antitumor activity against mouse B16-OVA cells implanted in mouse assessed as higher number of mouse cured of tumors at 10 ug administered intratumorally on day 6, 9 and 12 post implantation 31500996
点击查看更多细胞系数据

生物活性

产品描述 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium)是响应哺乳动物细胞质中的DNA产生的,并能以高亲和力结合 STING,且有效地诱导 interferon-β (IFNβ)。2',3'-cGAMP 结合 STING 的Kd值为3.79 nM。
靶点
STING [1]
(Cell-free assay)
3.79 nM(Kd)

化学信息&溶解度

分子量 718.37 分子式

C20H22N10Na2O13P2

CAS号 1441190-66-4 (free acid) SDF --
密度 g/mL
Smiles C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)O)O)O
储存条件(自收到货起) 3年 -20°C 粉状

体外溶解度
批次:

DMSO : 100 mg/mL ( (139.2 mM); DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Water : 100 mg/mL

Ethanol : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

* 必填项

请输入您的姓名
请输入您的邮箱地址 请输入一个有效的邮箱地址
请写点东西给我们
Tags: buy 2',3'-cGAMP Sodium Salt | 2',3'-cGAMP Sodium Salt supplier | purchase 2',3'-cGAMP Sodium Salt | 2',3'-cGAMP Sodium Salt cost | 2',3'-cGAMP Sodium Salt manufacturer | order 2',3'-cGAMP Sodium Salt | 2',3'-cGAMP Sodium Salt distributor
在线咨询
联系我们