目录号 产品目录 产品描述
S5326 Dolasetron Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. It has minimal activity at other known serotonin receptors, and has low affinity for dopamine receptors.
S1646 Ketorolac Ketorolac是一种非选择性的COX抑制剂,作用于人类COX-1COX-2时, IC50分别为1.23 µM和3.50 µM。
S5399 Chlorprothixene hydrochloride Chlorprothixene HCl is the hydrochloride salt form of chlorprothixene, a typical antipsychotic drug of the thioxanthene (tricyclic) class. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.
S5392 Mepivacaine Mepivacaine is a local anesthetic indicated for infiltration, nerve block, and epidural anesthesia.
S5416 Metyrapone Metyrapone is an inhibitor of the enzyme steroid 11-beta-monooxygenase that inhibits adrenal steroid synthesis.
S1021 Dasatinib Dasatinib是一种新型有效的多靶点抑制剂,作用于AblSrc和 c-Kit,在无细胞试验中IC50分别为 <1 nM,0.8 nM 和 79 nM。
S1378 Ruxolitinib (INCB018424) Ruxolitinib (INCB018424)是第一个应用于临床的,有效的,选择性JAK1/2抑制剂,在无细胞试验中IC50为3.3 nM/2.8 nM。作用于JAK1, JAK2与作用于JAK3相比,选择性高130多倍。
S4642 Dolutegravir Sodium Dolutegravir是HIV整合酶抑制剂,IC50为2.7 nM。
S1150 Paclitaxel Paclitaxel是一种microtubule聚合物稳定剂,在人内皮细胞中IC50为0.1 pM。
S1208 Doxorubicin (Adriamycin) HCl Doxorubicin (Adriamycin) HCl是一种抗生素类试剂,在肿瘤细胞中抑制DNA topoisomerase II,并诱导DNA损伤和凋亡。
S1261 Celecoxib Celecoxib是一种选择性COX-2抑制剂,在Sf9细胞中IC50为40 nM。
S1648 Cytarabine Cytarabine是一种抗代谢药,也是DNA synthesis抑制剂,在野生型CCRF-CEM细胞中IC50为16 nM。
S5278 Tedizolid (TR-700) Tedizolid is an oxazolidinone-class antibiotic prodrug used for the treatment of acute bacterial skin and skin structure infections caused by susceptible isolates of several Gram-positive bacteria.
S5238 Solifenacin (YM905) Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.
S5701 Alvimopan dihydrate (LY246736 dihydrate) Alvimopan (LY-246736) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors.
S9500 Valbenazine tosylate Valbenazine tosylate is the tosylate salt of valbenazine, a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no significant binding to VAMT1(Ki<10 μM).
S4848 Dalbavancin Dalbavancin是一种脂糖肽类抗生素,对革兰氏阳性菌,如多种葡萄状球菌,具有杀菌活性。
S5737 Diclofenac Epolamine Diclofenac Epolamine is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.
S5674 Lodoxamide Tromethamine Lodoxamide Tromethamine is the tromethamide salt form of lodoxamide, a synthetic mast cell stabilizing compound with anti-inflammatory activity.
S5254 Dasatinib hydrochloride Dasatinib hydrochloride is the hydrochloride salt form of dasatinib, an inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively.