API(仅用于科研)

目录号 产品目录 产品描述
S9321 Topotecan
S4021 Tolcapone Tolcapone是一种有效和选择性的可逆硝基酚类儿茶酚-O-甲基转移酶(COMT)抑制剂,Ki为30nM。
S4589 Amodiaquine dihydrochloride dihydrate Amodiaquine在人红细胞中是一种有效的、非竞争性的组胺N-甲基转移酶抑制剂,其Ki值为18.6 nM。它也被用作抗疟疾药和消炎药。
S4635 Cyproheptadine hydrochloride Cyproheptadine hydrochloride是非选择性的5HT2拮抗剂,其IC50为0.6 nM。它同时还是一个SETD7/9的抑制剂。
S3639 Tacrine hydrochloride hydrate Tacrine是胆碱酯酶(cholinesterase)抑制剂,可对抗骨骼肌松弛药的作用,可作为呼吸兴奋剂并用于治疗阿兹海默病和其他中枢神经系统障碍。它也是组胺N-甲基转移酶(histamine N-methyltransferase)
S3147 Entacapone Entacapone抑制儿茶酚-O-甲基转移酶(COMT)活性,IC50为151 nM。
S4245 Sodium ascorbate Sodium ascorbate作为抗氧化剂和酸度调节剂,在消除慢性和急性感染方面发挥重要作用。
S1026 Imatinib Mesylate (STI571) Imatinib Mesylate (STI571)是一种口服生物有效的Imatinib甲磺酸盐,是一种多靶点抑制剂,作用于v-Ablc-KitPDGFR,在无细胞和细胞试验中,IC50分别为0.6 μM,0.1 μM 和0.1 μM。
S1011 Afatinib (BIBW2992) Afatinib (BIBW2992)不可逆地抑制EGFR/ErbB,包括EGFR(wt)EGFR(L858R),EGFR(L858R/T790M),ErbB2(HER2)和ErbB4(HER4),在无细胞试验中IC50分别为0.5 nM,0.4 nM,10 nM,14 nM和1 nM。
S5077 Regorafenib Monohydrate Regorafenib是一种新型口服的多重激酶抑制剂,对VEGFR1、小鼠VEGFR2、小鼠VEGFR3、PDGFR-β、KIT、RET、RAF-1、B-RAF和B-RAF(V600E)的IC50分别为13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM。
S1311 Pamidronate Disodium Pamidronate Disodium 为含氮的双磷酸盐类药物,用于预防骨质疏松症。
S5739 Nebivolol Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
S5741 Quetiapine Quetiapine is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.
S1791 Bacitracin Zinc Bacitracin是一种抗生素,能够干扰C55-isoprenyl pyrophosphate的去磷酸化,C55-isoprenyl pyrophosphate是一种膜载体分子,参与转运构成肽聚糖细菌细胞壁内膜外部成分。Bacitracin抑制甲硫啡肽中Tyr的裂解,IC50为10 μM。
S5206 Benzylpenicillin potassium Benzylpenicillin potassium是青霉素G的钾盐形式,青霉素G是广谱的青霉素抗生素。
S5476 Rolapitant Rolapitant is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.
S5719 Ceftizoxime sodium Ceftizoxime sodium is a semisynthetic cephalosporin antibiotic that is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.
S4692 Succimer Succimer (DMSA) is an orally active metal chelator is used to treat heavy metal poisoning.
S5656 Diphenylpyraline hydrochloride Diphenylpyraline hydrochloride is the hydrochloride salt form of diphenylpyraline, which is an antihistamine used in the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
S5301 Carglumic Acid Carglumic Acid is an orally active, synthetic structural analogue of N-acetylglutamate (NAG) and carbamoyl phosphate synthetase 1 (CPS 1) activator, with ammonia lowering activity.