PROTAC

PROTAC

  • 目录号 产品号 产品描述
    S0070New Gefitinib-based PROTAC 3 Gefitinib-based PROTAC 3 通过连接器将EGFR结合元件与VHL配体偶联,可诱导 EGFR 及其突变体的降解,在HCC827(第19外显子)和H3255(L858R)中的DC50值分别为11.7 nM和22.3 nM。
    S0072New MS4078 MS4078 是一种 ALK 的抑制剂和PROTAC(降解剂)。MS4078 可降低SU-DHL-1细胞中 NPM-ALK 蛋白水平和NCI-H2228细胞中 EML4-ALK 蛋白水平,对应的DC50值分别为11 nM和59 nM。MS4078 可通过cereblon和蛋白酶体依赖性机制诱导ALK蛋白降解,并有效抑制SU-DHL-1细胞的增殖,其IC50值为33 nM。
    S0137New dBET57 dBET57 是一种基于PROTAC技术的新颖、有效且具有选择性的 BRD4BD1 的降解剂,其DC50/5h值为500 nM。dBET57在 BRD4BD2 上无效。
    S8296 dBET1 dBET1是一种基于CRBN的BET降解剂,对BRD4的IC50为20 nM,具有高选择性。在7429种检测蛋白中,只有肿瘤蛋白MYC、PIM1和BRD2、BRD3、BRD4的表达经dBET1处理后显著下降。
    S8297 ARV-825 ARV-825是一种BRD4抑制剂,可招募BRD4到E3泛素连接酶cereblon上,引起BRD4蛋白快速、有效和持续的降解,持续性下调MYC水平。
    S8532New ARV-771 ARV-771 是一种有效的 pan-(bromodomain and extra-terminal)BET 降解剂,一种新型的BET-PROTAC(proteolysis-targeting chimera),对于BRD2(1)、BRD2(2)、BRD3(1)、BRD3(2)、BRD4(1) 和 BRD4(2)的Kd值分别为34 nM、4.7 nM、8.3 nM、7.6 nM、9.6 nM 和 7.6 nM。
    S8762 dBET6 dBET6是一种具有良好的细胞通透性的BET bromodomainsPROTAC降解剂,与BRD4结合的IC50值为14 nM。dBET6 还可诱导c-MYC的下调和凋亡。
    S8785New A1874 A1874是一种基于nutlin,PROTAC类BRD4降解剂,能够以纳摩尔浓度将其目标蛋白降解98%。
    S8888New GMB-475 GMB-475 是一种靶向蛋白水解的嵌合体(PROTAC),它以变构方式靶向 BCR-ABL1 蛋白并募集 the E3 ligase Von Hippel-Lindau (VHL),从而导致泛素化并随后降解致癌融合蛋白。
  • 目录号 产品号 产品描述
    S0567 Amino-PEG4-alcohol Amino-PEG4-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. Amino-PEG4-alcohol is a non-cleavable 4-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    S0576 NH2-PEG2-C2-Boc NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG2-C2-Boc is a non-cleavable 2-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    S0590 Propargyl-PEG5-amine Propargyl-PEG5-amine is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker applied into the synthesis of PROTACs.
    S0593 Amino-PEG4-CH2COOH Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0603 m-PEG12-amine m-PEG12-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0605 Azido-PEG4-CH2-Boc Azido-PEG4-CH2-Boc is a cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
    S0611 Azido-PEG5-alcohol Azido-PEG5-alcohol is a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
    S0616 Azido-PEG2-C2-amine Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG2-C2-amine is a non-cleavable 2-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0640 NH2-PEG5-OH NH2-PEG5-OH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0642 Azido-PEG6-amine Azido-PEG6-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0646 Propargyl-PEG2-amine Propargyl-PEG2-amine is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs.
    S0663 Azido-PEG6-alcohol Azido-PEG6-alcohol is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG6-alcohol is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0664 m-PEG10-alcohol m-PEG10-alcohol is a non-cleavable 10-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). m-PEG10-alcohol is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
    S0668 Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
    S0670 N3-PEG3-CH2CH2-Boc N3-PEG3-CH2CH2-Boc is a cleavable 3-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
    S0687 NH2-PEG6-Boc NH2-PEG6-Boc is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0689 Bis-PEG8-acid Bis-PEG8-acid is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0696 Propargyl-PEG2-NHBoc Propargyl-PEG2-NHBoc is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs.
    S0698 Boc-NH-PEG4-CH2CH2COOH Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be applied into the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC).
    S1127New 3-Maleimidopropionic acid 3-Maleimidopropionic acid 是一种基于烷基链的 PROTAC linker,可用于PROTAC的合成。
    S1131 Amino-PEG3-C2-Amine Amino-PEG3-C2-Amine is a PEG-based PROTAC linker can be that is applicable to the synthesis of PROTACs.
    S1246 NH2-PEG3-C2-NH-Boc NH2-PEG3-C2-NH-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1279 Boc-NH-PEG2-C2-NH2 Boc-NH-PEG2-C2-NH2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1295 NH2-C4-NH-Boc NH2-C4-NH-Boc is a PROTAC linker that refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be applicable to the synthesis of a series of PROTACs.
    S1298 Boc-NH-PEG3 Boc-NH-PEG3 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1301 PEG5-Tos PEG5-Tos is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1306 Amino-PEG4-C2-amine Amino-PEG4-C2-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1307 NH2-PEG1-CH2CH2-Boc NH2-PEG1-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1309 3,6-Dioxaoctanedioic acid 36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1320 NH2-C2-NH-Boc NH2-C2-NH-Boc is a alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1347 Bis-NH2-PEG2 Bis-NH2-PEG2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1350 Bis-PEG3-acid Bis-PEG3-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1355 Boc-N-Amido-PEG2-C2-azide Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1365 Biotin-PEG6-alcohol Biotin-PEG6-alcohol is a biotin-labeled and PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1388 Azido-PEG2-CH2COOH Azido-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1411 Propargyl-PEG4-alcohol Propargyl-PEG4-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1414 m-PEG6-CH2CH2COOH m-PEG6-CH2CH2COOH is a PEG-based based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1417 Thiol-PEG8-acid Thiol-PEG8-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1418 Azido-PEG3-alcohol Azido-PEG3-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1429 BnO-PEG4-OH BnO-PEG4-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1447 Azido-PEG8-amine Azido-PEG8-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1449 Br-PEG4-OH Br-PEG4-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1495 Hydroxy-PEG5-Boc Hydroxy-PEG6-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1520 m-PEG5-acid m-PEG5-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1551 Azido-PEG1-CH2CO2H Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H is applicable to the synthesis of PROTAC BRD4 Degrader-1.
    S1552 Br-PEG3-C2-Boc Br-PEG3-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1559 Tos-PEG3 Tos-PEG3 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs. Tos-PEG3 can be used in the synthesis of 3'-aminooxy oligonucleotides solid supports.
    S1562 Mal-amido-PEG2-C2-acid Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1563 m-PEG6-O-CH2COOH m-PEG6-O-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1564 Diethylene glycol bis(p-toluenesulfonate) Diethylene glycol bis(p-toluenesulfonate) (Diethylene glycol di(p-toluenesulfonate), Bis-Tos-PEG2) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1566 Amino-PEG5-amine Amino-PEG5-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1581 Propargyl-PEG2-OH Propargyl-PEG2-OH is a PEG-based PROTAC linker that is applicable to the synthesis of Thalidomide-O-PEG2-propargyl.
    S1596 Biotin-PEG4-acid Biotin-PEG4-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTAC.
    S1597 3-(2-Pyridyldithio)propanoic Acid 3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1600 Dodecaethylene glycol Dodecaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1602 m-PEG8-thiol m-PEG8-thiol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1632 Boc-N-Amido-PEG3-azide Boc-N-Amido-PEG3-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1650 NH2-PEG3 NH2-PEG3 is a PROTAC linker that belongs to a polyethylene glycol (PEG) linker. NH2-PEG3 is applicable to the synthesis of the PROTAC (β-NF-JQ1).
    S1656 m-PEG3-Tos m-PEG3-Tos is a PEG-based PROTAC linker that is applicable to the synthesis of Silymarin.
    S1659 Br-C10-methyl ester Br-C10-methyl ester is a PROTAC linker that refers to the alkyl/ether composition. Br-C10-methyl ester is applicable to the synthesis of a series of PROTACs.
    S1660 2-(Benzyloxy)ethanol 2-(Benzyloxy)ethanol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1661 5-Ethynyl-2'-deoxyuridine 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1663 Nonaethylene glycol monomethyl ether Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1664 Di(N-succinimidyl)adipate Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1670 Azido-PEG4-Boc Azido-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1674 Amino-PEG4-Boc Amino-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1682 BnO-PEG5-OH BnO-PEG5-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1684 Br-PEG3-OH Br-PEG3-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1686 Bromo-PEG2-alcohol Bromo-PEG2-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1687 Bromo-PEG4-bromide Bromo-PEG4-bromide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1694 Boc-GABA-OH Boc-GABA-OH is a PROTAC linker that can be applied to synthesis UNC6852, an EED-targeted PROTAC.
    S1695 4-Maleimidobutyric acid 4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1697 Heptaethylene glycol Heptaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1699 Decaethylene glycol Decaethylene glycol (HO-PEG10-OH) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1710 Triethylene glycol monobenzyl ether Triethylene glycol monobenzyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1720 m-PEG5-NH2 m-PEG5-NH2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1722 PEG3-O-CH2COOH PEG3-O-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of SNIPERs.
    S1728 Hydroxy-PEG2-CH2COOH Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1745 Hydroxy-PEG3-CH2-Boc Hydroxy-PEG3-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1746 Azido-PEG5-amine Azido-PEG5-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1752 Octaethylene glycol Octaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1755 Pentaethylene glycol Pentaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1757 Amino-PEG9-amine Amino-PEG9-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1758 Hexane-1,6-diyldiphosphonic acid Hexane-1,6-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1765 Butane-1,4-diyldiphosphonic acid Butane-1,4-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1766 m-PEG7-alcohol m-PEG7-alcohol (O-Methyl-heptaethylene glycol) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1769 Bis-Tos-PEG6 Bis-Tos-PEG6 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1772 Bis-NH2-C1-PEG3 Bis-NH2-C1-PEG3 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1779 Pentaethylene glycol di(p-toluenesulfonate) Pentaethylene glycol di(p-toluenesulfonate) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1780 Propynol Ethoxylate Propynol Ethoxylate is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1781 Bis-Tos-PEG4 Bis-Tos-PEG4 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1783 1,2-Bis(2-iodoethoxy)ethane 1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane is applicable to the synthesis of MT802 and SJF620 which are potent PROTAC BTK degraders with DC50 of 1 nM and 7.9 nM, respectively.
    S1785 Nonaethylene glycol Nonaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1795 Amino-PEG7-amine Amino-PEG7-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1796 Monoethyl pimelate Monoethyl pimelate is a PROTAC linker that refers to the alkyl/ether composition. Monoethyl pimelate is applicable to the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-XL PROTAC degrader.
    S1797 Hydroxy-PEG6-CH2-Boc Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1798 Hydroxy-PEG1-CH2-Boc Hydroxy-PEG1-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1800 2,2-Oxybis(ethylamine) 22-Oxybis(ethylamine) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1803 Boc-NH-C4-acid Boc-NH-C4-acid is a PROTAC linker that belongs to a Alkyl/ether linker. Boc-NH-C4-acid is applicable to the synthesis of PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.
    S1804 Hexaethylene glycol Hexaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1809 Octaethylene glycol monomethyl ether Octaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1810 Pentaethylene glycol monomethyl ether Pentaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1812 Hexaethylene glycol monomethyl ether Hexaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1814 tert-Butyl 11-aminoundecanoate tert-Butyl 11-aminoundecanoate is a PROTAC linker that refers to the PEG composition. tert-Butyl 11-aminoundecanoate is applicable to the synthesis of a series of PROTACs.
    S1815 m-PEG2-azide m-PEG2-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1817 Bromo-PEG3-CH2-Boc Bromo-PEG3-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1818 Propargyl-PEG3-alcohol Propargyl-PEG3-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1821 Boc-NH-PEG7-azide Boc-NH-PEG7-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1824 Boc-NH-PEG7-acid Boc-NH-PEG7-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1838 Diethylene Glycol Monobenzyl Ether Diethylene Glycol Monobenzyl Ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1841 Tos-PEG5-CH2COOtBu Tos-PEG5-CH2COOtBu is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1842 NH2-PEG3-C1-Boc NH2-PEG3-C1-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1844 Fmoc-N-PEG7-acid Fmoc-N-amido-PEG7-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1846 Hydroxy-PEG4-O-Boc Hydroxy-PEG5-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1850 Bromo-PEG2-CH2-Boc Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1852 Br-PEG4-CH2-Boc Br-PEG4-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1860 HO-PEG13-OH HO-PEG13-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1861 Azido-PEG3-C-Boc Azido-PEG3-C-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1862 Tos-PEG4-CH2-Boc Tos-PEG4-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1864 Fmoc-NH-PEG1-C2-acid Fmoc-NH-PEG1-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1867 Tos-PEG1-CH2-Boc Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1868 Bromo-PEG1-CH2-Boc Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1870 N-Boc-4-pentyne-1-amine N-Boc-4-pentyne-1-amine is a PROTAC linker that refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine is applicable to the synthesis of the PROTAC MG-277.
    S1871 Hydroxy-PEG2-CH2-Boc Hydroxy-PEG2-CH2-Boc is a PEG/Alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1872 Amino-PEG1-C2-acid Amino-PEG1-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1877 Azido-PEG5-Boc Azido-PEG5-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1879 Boc-NH-PEG1-CH2COOH Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1882 NH2-PEG7 NH2-PEG7 is a PROTAC linker that refers to the PEG composition. NH2-PEG7 is applicable to the synthesis of the PROTAC PARP1 degrader iRucaparib-AP6.
    S1886 Boc-NH-PEG12-CH2CH2COOH Boc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1887 Propargyl-PEG4-acid Propargyl-PEG4-acid is a PEG-based PROTAC linker that is applicable to the synthesis of BTK-IAP PROTACs Ibrutinib-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with DC50 of 200 nM in THP-1 cells.
    S1892 N-Boc-PEG5-alcohol N-Boc-PEG5-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1901 Fmoc-amino-PEG3-CH2COOH Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1906 Bromo-PEG1-C2-Boc Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1912 3,6,9-Trioxaundecanedioic Acid 369-Trioxaundecanedioic Acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1918 Bromo-PEG2-C2-Boc Bromo-PEG2-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1919 Propargyl-PEG3-Boc Propargyl-PEG3-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1922 Propargyl-PEG4-Boc Propargyl-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1925 Amino-PEG3-CH2COOH Amino-PEG3-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1926 m-PEG5-CH2CH2COOH m-PEG5-CH2CH2COOH is a PEG-based based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1927 N-Boc-PEG8-alcohol N-Boc-PEG8-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1930 Mal-NH-Boc Mal-NH-Boc is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1931 Amino-PEG3-C2-Azido Amino-PEG3-C2-Azido is a PEG-based PROTAC linker that is applicable to the synthesis of the PARP1 degrader iRucaparib-TP3.
    S1932 m-PEG16-alcohol m-PEG16-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1935 Fmoc-NH-PEG8-NHS ester Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1936 Boc-NH-PEG8-CH2CH2COOH Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1938 Azido-PEG2-C2-acid Azido-PEG2-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1942 Boc-NH-PEG6-azide Boc-NH-PEG6-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1943 Amino-PEG2-NH-Boc Amino-PEG2-NH-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1944 m-PEG6-Br m-PEG6-Br is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1945 N-Boc-serinol N-Boc-serinol is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1946 Propargyl-PEG1-NH2 Propargyl-PEG1-NH2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1947 Biotin-PFP ester Biotin-PFP ester is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1948 HO-PEG14-OH HO-PEG14-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1951 Tetraethylene glycol Tetraethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1953 m-PEG3-OH m-PEG3-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1954 Triethylene glycol Triethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1955 Boc-NH-PEG2-CH2COOH Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1961 Boc-NH-PEG4 Boc-NH-PEG4 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1963 Boc-11-aminoundecanoic acid Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker that is applicable to the synthesis of MS432.
    S1966 Propargyl-PEG12-OH Propargyl-PEG12-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1967 Propargyl-PEG4-amine Propargyl-PEG4-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
  • 目录号 产品号 产品描述
    S0095New VL285 VL285 是一种有效的 VHL ligand 对应的IC50值为0.34 μM,可降解HaloTag7融合蛋白。HaloPROTAC3 衍生自 VL285。
    S0097New (S,R,S)-AHPC (MDK7526) (S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1)是一种 VH032-based VHL ligand,可用于募集 von Hippel-Lindau (VHL)蛋白。(S,R,S)-AHPC 可能对 androgen receptor 的靶向降解有用。(S,R,S)-AHPC 可以通过接头与蛋白质的配体例如BCR-ABL1连接,以形成PROTAC例如GMB-475。GMB-475 可在 Ba/F3 细胞中诱导BCR-ABL1降解,IC50值为1.11 μM。
    S0322 BC-1215 BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component) with IC50 of 0.9 μg/mL for IL-1β release. BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination.
    S1000 Thalidomide fluoride Thalidomide fluoride (Cereblon ligand 4, E3 ligase Ligand 4) is the Thalidomide-based Cereblon ligand that is applicable to the recruitment of CRBN protein. Thalidomide fluoride can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
    S1015 Thalidomide-OH Thalidomide-OH is the Thalidomide-based Cereblon ligand that is applicable to the recruitment of CRBN protein. Thalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs.
    S1016 Lenalidomide-Br Lenalidomide-Br is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is that is applicable to the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs.
    S1029New Lenalidomide (CC-5013) Lenalidomide (CC-5013)是一种TNF-α分泌抑制剂,在PBMCs中IC50为13 nM。Lenalidomide (CC-5013) 是 ubiquitin E3 ligase cereblon (CRBN) 的配体,它通过CRBN-CRL4泛素连接酶引起两个淋巴样转录因子IKZF1和IKZF3的选择性泛素化和降解。Lenalidomide 可促进 cleaved caspase-3 的表达、抑制 VEGF 的表达并诱导凋亡。
    S1062 (S,R,S)-AHPC hydrochloride (S,R,S)-AHPC hydrochloride is the VH032-based VHL ligand that is applicable to the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
    S1193 Thalidomide 沙利度胺作为一种镇静药,免疫调节剂,也用于研究治疗许多癌症的症状。沙利度胺抑制E3泛素连接酶(一种CRBN-DDB1-Cul4A复合物)。
    S1567 Pomalidomide Pomalidomide (CC-4047)抑制LPS诱导的TNF-α释放,在PBMCs中IC50为13 nM。Pomalidomide 可以在PROTAC中用作靶向 E3 ligase 和抑制 E3 ligase protein cereblon (CRBN)。Pomalidomide可促进凋亡和细胞周期阻滞。
    S6794New Thalidomide-O-COOH (Cereblon ligand 3) Thalidomide-O-COOH (Cereblon ligand 3, E3 ligase Ligand 3)是基于Thalidomide的 Cereblon (CRBN) 配体,可用于募集CRBN蛋白。Thalidomide-O-COOH (Cereblon ligand 3) 可以通过连接器与蛋白质的配体连接以形成 PROTACs (Proteolysis Targeting Chimera)。
    S8760 Iberdomide (CC220) Iberdomide (CC-220) 是一种新型口服免疫调节化合物,靶向cereblon(cereblon是CRL4CRBN E3泛素连接酶复合体的一部分),IC50为60 nM。Iberdomide (CC-220) 可诱导凋亡并具有抗肿瘤和免疫刺激的活性。
  • 目录号 产品号 产品描述
    S1526 Quizartinib (AC220) Quizartinib (AC220)是一种二代FLT3抑制剂,作用于Flt3(ITD/WT),在MV4-11和 RS4;11细胞中IC50分别为1.1 nM/4.2 nM,作用于Flt3比作用于KIT,PDGFRA,PDGFRB,RET,和CSF-1R选择性高10倍。Quizartinib (AC220)可诱导肿瘤细胞的凋亡。Phase 3。
    S2680New Ibrutinib (PCI-32765) Ibrutinib (PCI-32765)是一种有效的,高选择性的Brutons tyrosine kinase (Btk)抑制剂,无细胞试验中IC50为0.5 nM,对Bmx, CSK, FGR, BRK及HCK适度有效,对EGFR, Yes, ErbB2, JAK3等作用效果较弱。Ibrutinib 可作为Btk配体用于合成包括P13I在内的一系列PROTAC
    S6545 BI-4464 BI-4464是高选择性、ATP竞争性的PTK2/FAK抑制剂,IC50为17 nM。
    S7110New (+)-JQ1 (+)-JQ1是一种BET bromodomain抑制剂,作用于BRD4(1/2),无细胞试验中IC50为77 nM/33 nM,结合到BET家族的所有溴结构域,而不结合到BET家族以外的溴结构域。(+)-JQ1可通过诱导自噬来抑制细胞增殖。