PROTAC

PROTAC

  • 目录号 产品号 产品描述
    S0070 Gefitinib-based PROTAC 3 Gefitinib-based PROTAC 3 conjugates an EGFR binding element to a VHL ligand via a linker and induces EGFR degradation with DC50 of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.
    S0072 MS4078 MS4078 is a PROTAC (degrader) of anaplastic lymphoma kinase (ALK) with Kd of 19 nM for binding affinity to ALK.
    S0137 dBET57 dBET57 is a novel, potent and selective degrader of BRD4BD1 based on the PROTAC technology. dBET57 mediates recruitment to the CRL4CRBN E3 ubiquitin ligase, with DC50(5h) of 500 nM for BRD4BD1 but is inactive on BRD4BD2.
    S8296 dBET1 dBET1是一种基于CRBN的BET降解剂,对BRD4的IC50为20 nM,具有高选择性。在7429种检测蛋白中,只有肿瘤蛋白MYC、PIM1和BRD2、BRD3、BRD4的表达经dBET1处理后显著下降。
    S8297New ARV-825 ARV-825是一种BRD4抑制剂,可招募BRD4到E3泛素连接酶cereblon上,引起BRD4蛋白快速、有效和持续的降解,持续性下调MYC水平。
    S8532New ARV-771 ARV-771 是一种有效的 pan-(bromodomain and extra-terminal)BET 降解剂,一种新型的BET-PROTAC(proteolysis-targeting chimera),对于BRD2(1)、BRD2(2)、BRD3(1)、BRD3(2)、BRD4(1) 和 BRD4(2)的Kd值分别为34 nM、4.7 nM、8.3 nM、7.6 nM、9.6 nM 和 7.6 nM。
    S8762 dBET6 dBET6是一种具有良好的细胞通透性的BET bromodomainsPROTAC降解剂,与BRD4结合的IC50值为14 nM。dBET6 还可诱导c-MYC的下调和凋亡。
    S8785New A1874 A1874是一种基于nutlin,PROTAC类BRD4降解剂,能够以纳摩尔浓度将其目标蛋白降解98%。
    S8888New GMB-475 GMB-475 是一种靶向蛋白水解的嵌合体(PROTAC),它以变构方式靶向 BCR-ABL1 蛋白并募集 the E3 ligase Von Hippel-Lindau (VHL),从而导致泛素化并随后降解致癌融合蛋白。
  • 目录号 产品号 产品描述
    S0567 Amino-PEG4-alcohol Amino-PEG4-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. Amino-PEG4-alcohol is a non-cleavable 4-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    S0576 NH2-PEG2-C2-Boc NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG2-C2-Boc is a non-cleavable 2-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    S0590 Propargyl-PEG5-amine Propargyl-PEG5-amine is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker applied into the synthesis of PROTACs.
    S0593 Amino-PEG4-CH2COOH Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0603 m-PEG12-amine m-PEG12-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0605 Azido-PEG4-CH2-Boc Azido-PEG4-CH2-Boc is a cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
    S0611 Azido-PEG5-alcohol Azido-PEG5-alcohol is a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
    S0616 Azido-PEG2-C2-amine Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG2-C2-amine is a non-cleavable 2-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0640 NH2-PEG5-OH NH2-PEG5-OH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0642 Azido-PEG6-amine Azido-PEG6-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0646 Propargyl-PEG2-amine Propargyl-PEG2-amine is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs.
    S0663 Azido-PEG6-alcohol Azido-PEG6-alcohol is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG6-alcohol is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0664 m-PEG10-alcohol m-PEG10-alcohol is a non-cleavable 10-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). m-PEG10-alcohol is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
    S0668 Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
    S0670 N3-PEG3-CH2CH2-Boc N3-PEG3-CH2CH2-Boc is a cleavable 3-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
    S0687 NH2-PEG6-Boc NH2-PEG6-Boc is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0689 Bis-PEG8-acid Bis-PEG8-acid is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
    S0696 Propargyl-PEG2-NHBoc Propargyl-PEG2-NHBoc is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs.
    S0698 Boc-NH-PEG4-CH2CH2COOH Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be applied into the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC).
    S1127 3-Maleimidopropionic acid 3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1131 Amino-PEG3-C2-Amine Amino-PEG3-C2-Amine is a PEG-based PROTAC linker can be that is applicable to the synthesis of PROTACs.
    S1246 NH2-PEG3-C2-NH-Boc NH2-PEG3-C2-NH-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1279 Boc-NH-PEG2-C2-NH2 Boc-NH-PEG2-C2-NH2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1295 NH2-C4-NH-Boc NH2-C4-NH-Boc is a PROTAC linker that refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be applicable to the synthesis of a series of PROTACs.
    S1298 Boc-NH-PEG3 Boc-NH-PEG3 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1301 PEG5-Tos PEG5-Tos is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1306 Amino-PEG4-C2-amine Amino-PEG4-C2-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1307 NH2-PEG1-CH2CH2-Boc NH2-PEG1-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1309 3,6-Dioxaoctanedioic acid 36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1320 NH2-C2-NH-Boc NH2-C2-NH-Boc is a alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1347 Bis-NH2-PEG2 Bis-NH2-PEG2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1350 Bis-PEG3-acid Bis-PEG3-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1355 Boc-N-Amido-PEG2-C2-azide Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1365 Biotin-PEG6-alcohol Biotin-PEG6-alcohol is a biotin-labeled and PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1388 Azido-PEG2-CH2COOH Azido-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1411 Propargyl-PEG4-alcohol Propargyl-PEG4-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1414 m-PEG6-CH2CH2COOH m-PEG6-CH2CH2COOH is a PEG-based based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1417 Thiol-PEG8-acid Thiol-PEG8-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1418 Azido-PEG3-alcohol Azido-PEG3-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1429 BnO-PEG4-OH BnO-PEG4-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1447 Azido-PEG8-amine Azido-PEG8-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1449 Br-PEG4-OH Br-PEG4-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1495 Hydroxy-PEG5-Boc Hydroxy-PEG6-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1520 m-PEG5-acid m-PEG5-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1551 Azido-PEG1-CH2CO2H Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H is applicable to the synthesis of PROTAC BRD4 Degrader-1.
    S1552 Br-PEG3-C2-Boc Br-PEG3-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1559 Tos-PEG3 Tos-PEG3 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs. Tos-PEG3 can be used in the synthesis of 3'-aminooxy oligonucleotides solid supports.
    S1562 Mal-amido-PEG2-C2-acid Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1563 m-PEG6-O-CH2COOH m-PEG6-O-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1564 Diethylene glycol bis(p-toluenesulfonate) Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1566 Amino-PEG5-amine Amino-PEG5-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1581 Propargyl-PEG2-OH Propargyl-PEG2-OH is a PEG-based PROTAC linker that is applicable to the synthesis of Thalidomide-O-PEG2-propargyl.
    S1596 Biotin-PEG4-acid Biotin-PEG4-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTAC.
    S1597 3-(2-Pyridyldithio)propanoic Acid 3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1600 Dodecaethylene glycol Dodecaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1602 m-PEG8-thiol m-PEG8-thiol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1632 Boc-N-Amido-PEG3-azide Boc-N-Amido-PEG3-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1650 NH2-PEG3 NH2-PEG3 is a PROTAC linker that belongs to a polyethylene glycol (PEG) linker. NH2-PEG3 is applicable to the synthesis of the PROTAC (β-NF-JQ1).
    S1656 m-PEG3-Tos m-PEG3-Tos is a PEG-based PROTAC linker that is applicable to the synthesis of Silymarin.
    S1659 Br-C10-methyl ester Br-C10-methyl ester is a PROTAC linker that refers to the alkyl/ether composition. Br-C10-methyl ester is applicable to the synthesis of a series of PROTACs.
    S1660 2-(Benzyloxy)ethanol 2-(Benzyloxy)ethanol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1661 5-Ethynyl-2'-deoxyuridine 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1663 Nonaethylene glycol monomethyl ether Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1664 Di(N-succinimidyl)adipate Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1670 Azido-PEG4-Boc Azido-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1674 Amino-PEG4-Boc Amino-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1682 BnO-PEG5-OH BnO-PEG5-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1684 Br-PEG3-OH Br-PEG3-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1686 Bromo-PEG2-alcohol Bromo-PEG2-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1687 Bromo-PEG4-bromide Bromo-PEG4-bromide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1694 Boc-GABA-OH Boc-GABA-OH is a PROTAC linker that can be applied to synthesis UNC6852, an EED-targeted PROTAC.
    S1695 4-Maleimidobutyric acid 4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1697 Heptaethylene glycol Heptaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1699 Decaethylene glycol Decaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1710 Triethylene glycol monobenzyl ether Triethylene glycol monobenzyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1720 m-PEG5-NH2 m-PEG5-NH2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1722 PEG3-O-CH2COOH PEG3-O-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of SNIPERs.
    S1728 Hydroxy-PEG2-CH2COOH Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1745 Hydroxy-PEG3-CH2-Boc Hydroxy-PEG3-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1746 Azido-PEG5-amine Azido-PEG5-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1752 Octaethylene glycol Octaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1755 Pentaethylene glycol Pentaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1757 Amino-PEG9-amine Amino-PEG9-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1758 Hexane-1,6-diyldiphosphonic acid Hexane-1,6-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1765 Butane-1,4-diyldiphosphonic acid Butane-1,4-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1766 m-PEG7-alcohol m-PEG7-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1769 Bis-Tos-PEG6 Bis-Tos-PEG6 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1772 Bis-NH2-C1-PEG3 Bis-NH2-C1-PEG3 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1779 Pentaethylene glycol di(p-toluenesulfonate) Pentaethylene glycol di(p-toluenesulfonate) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1780 Propynol Ethoxylate Propynol Ethoxylate is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1781 Bis-Tos-PEG4 Bis-Tos-PEG4 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1783 1,2-Bis(2-iodoethoxy)ethane 1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane is applicable to the synthesis of MT802 and SJF620 which are potent PROTAC BTK degraders with DC50 of 1 nM and 7.9 nM, respectively.
    S1785 Nonaethylene glycol Nonaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1795 Amino-PEG7-amine Amino-PEG7-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1796 Monoethyl pimelate Monoethyl pimelate is a PROTAC linker that refers to the alkyl/ether composition. Monoethyl pimelate is applicable to the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-XL PROTAC degrader.
    S1797 Hydroxy-PEG6-CH2-Boc Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1798 Hydroxy-PEG1-CH2-Boc Hydroxy-PEG1-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1800 2,2-Oxybis(ethylamine) 22-Oxybis(ethylamine) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1803 Boc-NH-C4-acid Boc-NH-C4-acid is a PROTAC linker that belongs to a Alkyl/ether linker. Boc-NH-C4-acid is applicable to the synthesis of PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.
    S1804 Hexaethylene glycol Hexaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1809 Octaethylene glycol monomethyl ether Octaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1810 Pentaethylene glycol monomethyl ether Pentaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1812 Hexaethylene glycol monomethyl ether Hexaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1814 tert-Butyl 11-aminoundecanoate tert-Butyl 11-aminoundecanoate is a PROTAC linker that refers to the PEG composition. tert-Butyl 11-aminoundecanoate is applicable to the synthesis of a series of PROTACs.
    S1815 m-PEG2-azide m-PEG2-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1817 Bromo-PEG3-CH2-Boc Bromo-PEG3-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1818 Propargyl-PEG3-alcohol Propargyl-PEG3-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1821 Boc-NH-PEG7-azide Boc-NH-PEG7-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1824 Boc-NH-PEG7-acid Boc-NH-PEG7-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1838 Diethylene Glycol Monobenzyl Ether Diethylene Glycol Monobenzyl Ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1841 Tos-PEG5-CH2COOtBu Tos-PEG5-CH2COOtBu is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1842 NH2-PEG3-C1-Boc NH2-PEG3-C1-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1844 Fmoc-N-PEG7-acid Fmoc-N-amido-PEG7-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1846 Hydroxy-PEG4-O-Boc Hydroxy-PEG5-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1850 Bromo-PEG2-CH2-Boc Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1852 Br-PEG4-CH2-Boc Br-PEG4-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1860 HO-PEG13-OH HO-PEG13-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1861 Azido-PEG3-C-Boc Azido-PEG3-C-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1862 Tos-PEG4-CH2-Boc Tos-PEG4-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1864 Fmoc-NH-PEG1-C2-acid Fmoc-NH-PEG1-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1867 Tos-PEG1-CH2-Boc Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1868 Bromo-PEG1-CH2-Boc Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1870 N-Boc-4-pentyne-1-amine N-Boc-4-pentyne-1-amine is a PROTAC linker that refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine is applicable to the synthesis of the PROTAC MG-277.
    S1871 Hydroxy-PEG2-CH2-Boc Hydroxy-PEG2-CH2-Boc is a PEG/Alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1872 Amino-PEG1-C2-acid Amino-PEG1-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1877 Azido-PEG5-Boc Azido-PEG5-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1879 Boc-NH-PEG1-CH2COOH Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1882 NH2-PEG7 NH2-PEG7 is a PROTAC linker that refers to the PEG composition. NH2-PEG7 is applicable to the synthesis of the PROTAC PARP1 degrader iRucaparib-AP6.
    S1886 Boc-NH-PEG12-CH2CH2COOH Boc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1887 Propargyl-PEG4-acid Propargyl-PEG4-acid is a PEG-based PROTAC linker that is applicable to the synthesis of BTK-IAP PROTACs Ibrutinib-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with DC50 of 200 nM in THP-1 cells.
    S1892 N-Boc-PEG5-alcohol N-Boc-PEG5-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1901 Fmoc-amino-PEG3-CH2COOH Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1906 Bromo-PEG1-C2-Boc Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1912 3,6,9-Trioxaundecanedioic Acid 369-Trioxaundecanedioic Acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1918 Bromo-PEG2-C2-Boc Bromo-PEG2-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1919 Propargyl-PEG3-Boc Propargyl-PEG3-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1922 Propargyl-PEG4-Boc Propargyl-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1925 Amino-PEG3-CH2COOH Amino-PEG3-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1926 m-PEG5-CH2CH2COOH m-PEG5-CH2CH2COOH is a PEG-based based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1927 N-Boc-PEG8-alcohol N-Boc-PEG8-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1930 Mal-NH-Boc Mal-NH-Boc is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1931 Amino-PEG3-C2-Azido Amino-PEG3-C2-Azido is a PEG-based PROTAC linker that is applicable to the synthesis of the PARP1 degrader iRucaparib-TP3.
    S1932 m-PEG16-alcohol m-PEG16-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1935 Fmoc-NH-PEG8-NHS ester Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1936 Boc-NH-PEG8-CH2CH2COOH Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1938 Azido-PEG2-C2-acid Azido-PEG2-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1942 Boc-NH-PEG6-azide Boc-NH-PEG6-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1943 Amino-PEG2-NH-Boc Amino-PEG2-NH-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1944 m-PEG6-Br m-PEG6-Br is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1945 N-Boc-serinol N-Boc-serinol is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1946 Propargyl-PEG1-NH2 Propargyl-PEG1-NH2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1947 Biotin-PFP ester Biotin-PFP ester is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1948 HO-PEG14-OH HO-PEG14-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1951 Tetraethylene glycol Tetraethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1953 m-PEG3-OH m-PEG3-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1954 Triethylene glycol Triethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1955 Boc-NH-PEG2-CH2COOH Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1961 Boc-NH-PEG4 Boc-NH-PEG4 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1963 Boc-11-aminoundecanoic acid Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker that is applicable to the synthesis of MS432.
    S1966 Propargyl-PEG12-OH Propargyl-PEG12-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
    S1967 Propargyl-PEG4-amine Propargyl-PEG4-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
  • 目录号 产品号 产品描述
    S0095 VL285 VL285 is a potent VHL ligand with IC50 of 0.34 μM. VL285 degrades HaloTag7 fusion proteins.
    S0097 (S,R,S)-AHPC (MDK7526) (S,R,S)-AHPC (MDK7526) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 induces the degradation of BCR-ABL1 with IC50 of 1.11 μM in Ba/F3 cells.
    S0322 BC-1215 BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component) with IC50 of 0.9 μg/mL for IL-1β release. BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination.
    S1000 Thalidomide fluoride Thalidomide fluoride is the Thalidomide-based Cereblon ligand that is applicable to the recruitment of CRBN protein. Thalidomide fluoride can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
    S1015 Thalidomide-OH Thalidomide-OH is the Thalidomide-based Cereblon ligand that is applicable to the recruitment of CRBN protein. Thalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs.
    S1016 Lenalidomide-Br Lenalidomide-Br is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is that is applicable to the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs.
    S1029New Lenalidomide (CC-5013) Lenalidomide (CC-5013)是一种TNF-α分泌抑制剂,在PBMCs中IC50为13 nM。Lenalidomide (CC-5013) 是 ubiquitin E3 ligase cereblon (CRBN) 的配体,它通过CRBN-CRL4泛素连接酶引起两个淋巴样转录因子IKZF1和IKZF3的选择性泛素化和降解。
    S1062 (S,R,S)-AHPC hydrochloride (S,R,S)-AHPC hydrochloride is the VH032-based VHL ligand that is applicable to the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
    S1193 Thalidomide 沙利度胺作为一种镇静药,免疫调节剂,也用于研究治疗许多癌症的症状。沙利度胺抑制E3泛素连接酶(一种CRBN-DDB1-Cul4A复合物)。
    S1567 Pomalidomide Pomalidomide抑制LPS诱导的TNF-α释放,在PBMCs中IC50为13 nM。Pomalidomide 可以在PROTAC中用作靶向 E3 ligase 和抑制 E3 ligase protein cereblon (CRBN)。Pomalidomide可促进凋亡和细胞周期阻滞。
    S6794New Thalidomide-O-COOH (Cereblon ligand 3) Thalidomide-O-COOH (Cereblon ligand 3) 是基于Thalidomide的 Cereblon (CRBN) 配体,可用于募集CRBN蛋白。Thalidomide-O-COOH (Cereblon ligand 3) 可以通过连接器与蛋白质的配体连接以形成 PROTACs (Proteolysis Targeting Chimera)。
    S8760 Iberdomide(CC220) Iberdomide (CC-220)是一种新型口服免疫调节化合物,靶向cereblon(cereblon是CRL4CRBN E3泛素连接酶复合体的一部分),IC50为60 nM。
  • 目录号 产品号 产品描述
    S1526 Quizartinib (AC220) Quizartinib (AC220)是一种二代FLT3抑制剂,作用于Flt3(ITD/WT),在MV4-11和 RS4;11细胞中IC50分别为1.1 nM/4.2 nM,作用于Flt3比作用于KIT,PDGFRA,PDGFRB,RET,和CSF-1R选择性高10倍。Quizartinib (AC220)可诱导肿瘤细胞的凋亡。Phase 3。
    S2680New Ibrutinib (PCI-32765) Ibrutinib (PCI-32765)是一种有效的,高选择性的Brutons tyrosine kinase (Btk)抑制剂,无细胞试验中IC50为0.5 nM,对Bmx, CSK, FGR, BRK及HCK适度有效,对EGFR, Yes, ErbB2, JAK3等作用效果较弱。Ibrutinib 可作为Btk配体用于合成包括P13I在内的一系列PROTAC
    S6545New BI-4464 BI-4464是高选择性、ATP竞争性的PTK2/FAK抑制剂,IC50为17 nM。
    S7110New (+)-JQ1 (+)-JQ1是一种BET bromodomain抑制剂,作用于BRD4(1/2),无细胞试验中IC50为77 nM/33 nM,结合到BET家族的所有溴结构域,而不结合到BET家族以外的溴结构域。(+)-JQ1可通过诱导自噬来抑制细胞增殖。