Quizartinib (AC220)

For research use only. Not for use in humans.

目录号：S1526 中文名称：奎扎替尼

CAS No. 950769-58-1

Quizartinib (AC220)是一种二代FLT3抑制剂，作用于Flt3(ITD/WT)，在MV4-11和 RS4;11细胞中IC50分别为1.1 nM/4.2 nM，作用于Flt3比作用于KIT，PDGFRA，PDGFRB，RET，和CSF-1R选择性高10倍。Quizartinib (AC220)可诱导肿瘤细胞的凋亡。Phase 3。

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10mM (1mL in DMSO)	RMB 2891.02	现货
5mg	RMB 1729.76	现货
50mg	RMB 7933.51	现货
200mg	RMB 20229.3	现货
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客户使用Selleck生产的Quizartinib (AC220)发表文献94篇：

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Blood Cancer J, 2021, 11(3):57

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Cell Death Discov, 2021, 7(1):121

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Front Immunol, 2021, 12:699128

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Cancer Discov, 2021, candisc.0738.2020

PubMed: 33436370 ( click the link to review the publication )

Mol Cancer Ther, 2021, 20(4):676-690

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Drug Metab Dispos, 2021, 49(1):53-61

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Oncol Lett, 2021, 21(5):397

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Hum Cell, 2021, 10.1007/s13577-021-00579-z

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Thorac Cancer, 2021, 10.1111/1759-7714.13849

PubMed: 33566442 ( click the link to review the publication )

Cell Rep, 2020, 33(1):108221

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Haematologica, 2020, 15 pii: haematol 2019 244020

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Mol Cell Proteomics, 2020, 10.1074/mcp.RA119.001504

PubMed: 32102969 ( click the link to review the publication )

Eur J Med Chem, 2020, 193:112232

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J Cell Mol Med, 2020, 25

PubMed: 32450611 ( click the link to review the publication )

J Cell Mol Med, 2020, 24(3):2308-2318

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Sci Rep, 2020, 10(1):16187

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Sci Rep, 2020, 10(1):1906

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Transl Oncol, 2020, 1;13(4):100766

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Hum Cell, 2020, 10.1007/s13577-020-00420-z

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Cancer Cell, 2020, 38(6):872-890.e6

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Pharmacol Res, 2020, 151:104556

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FEBS Open Bio, 2020, 10.1002/2211-5463.12827

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Sci Transl Med, 2019,

PubMed: 31484791 ( click the link to review the publication )

Autophagy, 2019, 15(9):1558-1571

PubMed: 30821613 ( click the link to review the publication )

Cell Rep, 2019, 28(9):2331-2344

PubMed: 31461650 ( click the link to review the publication )

Cancer Discov, 2019, 9(6):756-777

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Int J Mol Sci, 2019, 20(19)

PubMed: 31554189 ( click the link to review the publication )

Theriogenology, 2019, 126:145-152

PubMed: 30553232 ( click the link to review the publication )

Cell Rep, 2019, 26(11):2916-2928.e13

PubMed: 30865883 ( click the link to review the publication )

Hemasphere, 2019, 3(2):e182

PubMed: 31723821 ( click the link to review the publication )

FEBS Lett, 2019, 593(16):2162-2176

PubMed: 31135968 ( click the link to review the publication )

Oncotarget, 2019, 10(58):6111-6123

PubMed: 31692922 ( click the link to review the publication )

Blood, 2018, 25;131(4):426-438

PubMed: 29187377 ( click the link to review the publication )

Blood, 2018, 132(1):67-77.

PubMed: 29784639 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(7):1716-1726

PubMed: 29330206 ( click the link to review the publication )

Leukemia, 2018, 32(2):313-322

PubMed: 28895560 ( click the link to review the publication )

Haematologica, 2018, haematol.2018.189399

PubMed: 29748445 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(10):2417-2429

PubMed: 29463558 ( click the link to review the publication )

Oncogene, 2018, 37(6):787-797

PubMed: 29059168 ( click the link to review the publication )
mBio, 2018, 9(2)e00682-18

PubMed: 29691342 ( click the link to review the publication )

Cell Death Dis, 2018, 9(2):138

PubMed: 29374185 ( click the link to review the publication )

Neoplasia, 2018, 20(1):1-11

PubMed: 29172076 ( click the link to review the publication )

Nephrol Dial Transplant, 2018, 10.1093/ndt/gfy385

PubMed: 30590794 ( click the link to review the publication )

PLoS One, 2018, 13(1):e0190682

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PLoS One, 2018, 13(5):e0196805

PubMed: 29723246 ( click the link to review the publication )

Exp Hematol, 2018, 58:52-58

PubMed: 28947392 ( click the link to review the publication )

J Ophthalmol, 2018, 2018:2518568

PubMed: 29854425 ( click the link to review the publication )

Oncotarget, 2018, 9(76):34240-34258

PubMed: 30344940 ( click the link to review the publication )

Leukemia, 2018, 32(11):2374-2387

PubMed: 29743719 ( click the link to review the publication )

Oncotarget, 2018, 9(24):16917-16931

PubMed: 29682194 ( click the link to review the publication )

Blood, 2017, 130(1):48-58

PubMed: 28490572 ( click the link to review the publication )

Leukemia, 2017, 31(11):2336-2346

PubMed: 28280274 ( click the link to review the publication )

Cancer Res, 2017, 77(7):1697-1708

PubMed: 28108507 ( click the link to review the publication )

Leuk Lymphoma, 2017, 10.1080/10428194.2017.1289522

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Blood Adv, 2017, 1(20):1635-1644

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Oncotarget, 2017, 8(32):52026-52044

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Blood, 2016, 127(23):2890-902

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Cancer Res, 2016, 76(6):1528-37

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Sci Rep, 2016, 6:28032

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Ann Hematol, 2016, 95(5):783-91

PubMed: 26891877 ( click the link to review the publication )

PLoS One, 2016, 11(7):e0158290

PubMed: 27387666 ( click the link to review the publication )

Int J Hematol, 2016, 103(1):95-106

PubMed: 26590920 ( click the link to review the publication )
Oncotarget, 2016, 7(31):49786-49799

PubMed: 27391351 ( click the link to review the publication )

Oncotarget, 2016, 7(12):13886-901

PubMed: 26883104 ( click the link to review the publication )

Leukemia, 2015, 29(12):2382-9

PubMed: 26172401 ( click the link to review the publication )

Leukemia, 2015, 29(4):828-38

PubMed: 25322685 ( click the link to review the publication )

Leukemia, 2015, 29(12):2390-2

PubMed: 26108694 ( click the link to review the publication )

Sci Adv, 2015, 1(8):e1500221

PubMed: 26601252 ( click the link to review the publication )

Oncotarget, 2015, 6(35):38061-78

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Blood, 2014, 123(18):2826-37

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Blood, 2014, 123(5):734-42

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Nat Commun, 2014, 5:3672

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Clin Cancer Res, 2014, 20(8):2092-103

PubMed: 24436473 ( click the link to review the publication )

Leukemia, 2014, 28(2):293-301

PubMed: 23748345 ( click the link to review the publication )

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PubMed: 24699302 ( click the link to review the publication )

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Proc Natl Acad Sci USA, 2014, 10.1073/pnas.1320661111

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PLoS One, 2013, 8(9):e74653

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产品安全说明书

Target Protein Ligand抑制剂选择性比较

生物活性

产品描述

特性

AC220是二代FLT3抑制剂，且作为临床FLT3抑制剂的第一候选药。

靶点

FLT3 (ITD) ^[1] (MV4-11 cells)	FLT3 (WT) ^[1] (RS4;11 cells)
1.1 nM	4.2 nM

体外研究

AC220是最有效的FLT3选择性抑制剂，可用于治疗急性骨髓性白血病(AML)。AC220在生化和细胞实验中具有低纳摩尔效果和特别的激酶选择性，抑制大部分人类蛋白激酶时具有高选择性。AC220是治疗急性骨髓性白血病(AML)的新型FLT3抑制剂。^[1]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
HL60/VCR	NFfZNJVHfW6ldHnvckBCe3OjeR?=	Mn\1NE4yNTFyIN88US=>	NEfLWlI{OCCvaX6=	MWHlcohidmOnczD1dJRic2Vib3[gd5Vje3S{YYTld{Bw\iCDQlPHNkBidmRiQVLDRlEhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZI>	NFnTdmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2O\|E4Pyd-MkO5OlcyPzd:L3G+
K562/ABCB1	NWfNSmM1TnWwY4Tpc44hSXO\|YYm=	NFWzW3gxNjFvMUCg{txO	M2DIWlMxKG2rbh?=	Mmmw[Y5p[W6lZYOgeZB1[WunIH;mJJN2[nO2cnH0[ZMhd2ZiQVLDS\|Ih[W6mIFHCR2IyKGmwIHGgZ49v[2WwdILheIlwdi2mZYDlcoRmdnRibXHucoVz	M{jselxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[3NVc4Lz5{M{m2O\|E4PzxxYU6=
8226/MR20	NVm2XJB7TnWwY4Tpc44hSXO\|YYm=	M3uwNlAvOS1zMDFOwG0>	NXv4[4lZOzBibXnu	NYfjenV5\W6qYX7j[ZMhfXC2YXvlJI9nKHO3YoP0doF1\XNib3[gRWJETzJiYX7kJGFDS0JzIHnuJIEh[2:wY3XueJJifGmxbj3k[ZBmdmSnboSgcYFvdmW{	M37VOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[3NVc4Lz5{M{m2O\|E4PzxxYU6=
K562/ABCG2	MV7GeY5kfGmxbjDBd5NigQ>?	NFrCVXYxNjFvMUCg{txO	NHHVOZg{OCCvaX6=	NFLUWIVmdmijbnPld{B2eHSja3Wgc4Yhe3Wkc4TyZZRmeyCxZjDBRmNIOiCjbnSgRWJESjFiaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XJ?	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4N{G3O{c,OjN7NkexO\|c9N2F-
MCF-7 FLV1000	NEn5NoRMcW6jc3WgRZN{[Xl?	NYLtVHZKOOLCk{OwJOK2VQ>?	Mn3TOUBucW5?	MoXI[IVkemWjc3XzJHsyOjWLXT3JRWFRKHCqb4TvcIFj\Wyrbnegc4YhSUKFQkGgZZQhUUN3MDDv[kA{NjNizszN	MmeyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkexO\|coRjJ\|OU[3NVc4RC:jPh?=
MCF-7 FLV1000	NEHQN5JMcW6jc3WgRZN{[Xl?	MkjNNQKBmzNyINM1US=>	NWrnfYloPSCvaX6=	MYLk[YNz\WG\|ZYOgX\|EzPUmfLVnBRXAheGixdH;sZYJmdGmwZzDv[kBCSkOEMjDheEBKSzVyIH;mJFAvODdizszN	Mni0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkexO\|coRjJ\|OU[3NVc4RC:jPh?=
K562/ABCG2	MlnCR4VtdCCYaXHibYxqfHliQYPzZZl{	NVnZ[3Z3OC5zL{CuOU8yKML3TR?=	NYjDb4tiQTZiaB?=	NGnOPWd{\W6\|aYTpfoV{KEt3NkKvRWJETzJiY3XscJMhfG9ibXn0c5hidnS{b37lJJRweG:2ZXPhcuKh	NXvvWpNFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlcyPzdpPkKzPVY4OTd5PD;hQi=>
8226/MR20	MVPD[YxtKF[rYXLpcIl1gSCDc4PhfZM>	MnXKNE4yKML3TR?=	MX[5OkBp	Mkm5d4Vve2m2aYrld{BMPTZ{L1HCR2czKGOnbHzzJJRwKG2rdH;4ZY51em:wZTD0c5BwfGWlYX9CpC=>	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4N{G3O{c,OjN7NkexO\|c9N2F-
HMC1.1	NEO1ZWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Ml7kTWM2OD1zNDDuUS=>	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR7N{OxO{c,OjN2OUezNVc9N2F-
HMC1.2	NYrOVGxvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MUnJR\|UxRTF5Mkegcm0>	M1zpdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEm3N\|E4Lz5{M{S5O\|MyPzxxYU6=
p815	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MX;JR\|UxRTR2NTDuUS=>	NXf2[YVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVc{OTdpPkKzOFk4OzF5PD;hQi=>
Kasumi-1	NUfSZ5Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NV:2V4ZbUUN3ME2zOkBvVQ>?	NIfvbJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5O\|MyPyd-MkO0PVc{OTd:L3G+
M-07e + SCF	NIj1[\|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MVTJR\|UxRTd5IH7N	NH\YbHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5O\|MyPyd-MkO0PVc{OTd:L3G+
EOL-1	MnW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MmPaTWM2OD1zIH7N	NV;sfIpnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVc{OTdpPkKzOFk4OzF5PD;hQi=>
MV4;11	M1;0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NX\GW4l1UUN3MEygNUBvVQ>?	M4r2ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEm3N\|E4Lz5{M{S5O\|MyPzxxYU6=
MOLM14	Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NUfmUnpjUUN3MEygNUBvVQ>?	Mmn1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUezNVcoRjJ\|NEm3N\|E4RC:jPh?=
Pat.221	M3nMOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NXzuPWxQUUN3ME22O\|Uhdk1?	NV\oU4xrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVc{OTdpPkKzOFk4OzF5PD;hQi=>
Pat.279	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NFHPXIFKSzVyPUO0N\|Qhdk1?	MofLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUezNVcoRjJ\|NEm3N\|E4RC:jPh?=
Pat.299	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MXLJR\|UxRTd{NEigcm0>	NFr2UZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5O\|MyPyd-MkO0PVc{OTd:L3G+
Pat.305	M1jvUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4\E[GlEPTB;N{C3PUBvVQ>?	Mn3BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUezNVcoRjJ\|NEm3N\|E4RC:jPh?=
Pat.375	M4jHeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MWTJR\|UxRTVyMzDuUS=>	M4eybFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEm3N\|E4Lz5{M{S5O\|MyPzxxYU6=
Pat.379	MoL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MkXzTWM2OD16ME[gcm0>	NETvcoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5O\|MyPyd-MkO0PVc{OTd:L3G+
Pat.368	MoHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NX7vd3RsUUN3ME2yO\|AxKG6P	NUP1ZYVjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVc{OTdpPkKzOFk4OzF5PD;hQi=>
Pat.601	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MnjDTWM2OD1zMUWzJI5O	M1fmfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEm3N\|E4Lz5{M{S5O\|MyPzxxYU6=
HMC1.1	MojjRZBweHSxc3nzJGF{e2G7			M3rzOWlEPTB;M{Ggcm0>	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR7N{OxO{c,OjN2OUezNVc9N2F-
p815	NILTe3JCeG:ydH;zbZMhSXO\|YYm=			M33abGlEPTB;M{SxJI5O	MlP2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUezNVcoRjJ\|NEm3N\|E4RC:jPh?=
Kasumi-1	NFnGXHZCeG:ydH;zbZMhSXO\|YYm=			Ml\ZTWM2OD14NzDuUS=>	MoLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUezNVcoRjJ\|NEm3N\|E4RC:jPh?=
M-07e + SCF	NVLkVGJFSXCxcITvd4l{KEG\|c3H5			M4[5R2lEPTB;N{igcm0>	NU\JT3o4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVc{OTdpPkKzOFk4OzF5PD;hQi=>
EOL-1	M12yTmFxd3C2b4Ppd{BCe3OjeR?=			MnvvTWM2ODxiMTDuUS=>	M{iz[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEm3N\|E4Lz5{M{S5O\|MyPzxxYU6=
MV4;11	MnO0RZBweHSxc3nzJGF{e2G7			Mn[wTWM2OD1{IH7N	M1vtS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEm3N\|E4Lz5{M{S5O\|MyPzxxYU6=
MOLM14	MYXBdI9xfG:\|aYOgRZN{[Xl?			NWWy[o5DUUN3ME2zJI5O	NInxNJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5O\|MyPyd-MkO0PVc{OTd:L3G+
GIST822	MmnnRZBweHSxc3nzJGF{e2G7			NIjL[nhKSzVyPUGwPUBvVQ>?	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR7N{OxO{c,OjN2OUezNVc9N2F-
Pat.368	Mnf2RZBweHSxc3nzJGF{e2G7			M1rqcWlEPTB;Mkm5PEBvVQ>?	NGjHfnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5O\|MyPyd-MkO0PVc{OTd:L3G+
Pat.601	NG\uO4FCeG:ydH;zbZMhSXO\|YYm=			MXfJR\|UxRTh5NjDuUS=>	NVrJeph3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVc{OTdpPkKzOFk4OzF5PD;hQi=>
MV4-11	MmLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MXy3NkBp	MnqxTWM2OD1yLkOgcm0>	Mn;FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MUK5N\|EoRjJ\|NEGyPVMyRC:jPh?=
MOLM-14	NVrubm5tT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MWC3NkBp	NUjaXHNNUUN3ME2wMlEhdk1?	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzMkmzNUc,OjN2MUK5N\|E9N2F-
SEM-K2	M{TkUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NF3ZUVA4OiCq	MkfoTWM2OD1yLkSgcm0>	NHToU5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxNlk{OSd-MkO0NVI6OzF:L3G+
RS4;11	MlqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MV63NkBp	MlvwTWM2OD5zMDywNFAhdk1?	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzMkmzNUc,OjN2MUK5N\|E9N2F-
THP-1	NX20fnh6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NUHGdWtZPzJiaB?=	MmH0TWM2OD5zMDywNFAhdk1?	NGPFdos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxNlk{OSd-MkO0NVI6OzF:L3G+
MV4-11	NVjPR\|BRSXCxcITvd4l{KEG\|c3H5		MmnLPE8zPCCq	MYjpcoR2[2W\|IIPp[45q\mmlYX70JIFv\CCmb4PlMYRmeGWwZHXueEBRSVKSIHPs[YF3[WenIHHu[EBi[2O3bYXsZZRqd25ib3[gd5VjNTKQIFTORS=>	NHm0R4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxNlk{OSd-MkO0NVI6OzF:L3G+
MOLM-14	NVXFS5ozSXCxcITvd4l{KEG\|c3H5		NVT5WG5TQC9{NDDo	NFTxVJhqdmS3Y3XzJJNq\26rZnnjZY51KGGwZDDkc5NmNWSncHXu[IVvfCCSQWLQJINt\WG4YXflJIFv\CCjY3P1cZVt[XSrb36gc4Yhe3WkLULOJGRPSQ>?	M{DYSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEGyPVMyLz5{M{SxNlk{OTxxYU6=
SEM-K2	MnTZRZBweHSxc3nzJGF{e2G7		NXm3ZoFxQC9{NDDo	MXXpcoR2[2W\|IIPp[45q\mmlYX70JIFv\CCmb4PlMYRmeGWwZHXueEBRSVKSIHPs[YF3[WenIHHu[EBi[2O3bYXsZZRqd25ib3[gd5VjNTKQIFTORS=>	NVLSN29xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVI6OzFpPkKzOFEzQTNzPD;hQi=>
AML	MX7DfZRwfG:6aXPpeJkh[XO\|YYm=			MlvCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRW1NKGOnbHzzJIl{d2yjdHXkJIZzd21icnXsZZB{\WRiYXP1eIUhdXmnbH;p[EBt\XWtZX3pZUBx[XSrZX70JIhiemKxcnnu[{BHVFR\|IFnUSEBufXSjdHnvckBjgSCPVGSgZZN{[XluIFnDOVAhRSByLkCwNFMh\|ryPLh?=	NIDjR5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[1OFQxQCd-MUm2OVQ1ODh:L3G+
MV4-11	NXvDV5kzS3m2b4TvfIlkcXS7IHHzd4F6		MXG3NkBpenN?	NHXud5BEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOXjRvMUGgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvYnz1[UBie3OjeTygTWM2OCB;IECuNFAxPTZizszNMi=>	NIfxV5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[1OFQxQCd-MUm2OVQ1ODh:L3G+
blast cells	Mn71SpVv[3Srb36gZZN{[Xl?		M3XtPFIhcHK\|	NHX3WYZKdmirYnn0bY9vKG:oIF\MWFMhUVSGIH31eIFvfCCjdYTvdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIHLsZZN1KGOnbHzzJIFnfGW{IEKgbJJ{KGK7IHXs[YN1em:laHXtbYx2dWmwZYPj[Y5k\SxiSVO1NEA:KDBwMECwPEDPxE1w	M17SclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkW0OFA5Lz5zOU[1OFQxQDxxYU6=
RS4-11	M1vUNmZ2dmO2aX;uJIF{e2G7		NFTXT5kzKGi{cx?=	MoiyTY5pcWKrdHnvckBw\iCITGSzJGlVTCCvdYThcpQh[XW2b4Doc5NxcG:{eXzheIlwdiCrbjDoeY1idiCUU{StNVEh[2WubIOgZYZ1\XJiMjDodpMh[nliZXzlZ5Rzd2OqZX3pcJVucW6nc3PlcoNmKGG\|c3H5MEBKSzVyIE2gNE4xODFzIN88UU4>	NV;VN3hKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2OVQ1ODhpPkG5OlU1PDB6PD;hQi=>
AML	MkPRSpVv[3Srb36gZZN{[Xl?			MULJcohq[mm2aX;uJI9nKE[OVEOgZZV1d3Cqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBCVUxiY3XscJMhcXOxbHH0[YQh\nKxbTDy[YxieHOnZDDhZ5V1\SCveXXsc4llKGyndXvlcYliKHCjdHnlcpQh[nliV3XzeIVzdiCkbH;0eIlv\yxiSVO1NEA:KDBwMECyJO69VS5?	MkjkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4NUS0NFgoRjF7NkW0OFA5RC:jPh?=
RS4-11	NXHC[nBPTnWwY4Tpc44h[XO\|YYm=		NYPBe\|RyOiCqcoO=	NF[zeFRKdmirYnn0bY9vKG:oIF\MWFMh[XW2b4Doc5NxcG:{eXzheIlwdiCrbjDoeY1idiCUU{StNVEh[2WubIOgZYZ1\XJiMjDodpMh[nliZXzlZ5Rzd2OqZX3pcJVucW6nc3PlcoNmKGG\|c3H5MEBKSzVyIE2gNE4xODR{IN88UU4>	NVXQRlljRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2OVQ1ODhpPkG5OlU1PDB6PD;hQi=>
MV4-11	NIHqSWxCdnSrdIXtc5Ih[XO\|YYm=	MWKxNEBu\y:tZx?=	MYi2NEBl[Xm\|	M1jae2FvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3WOE0yOSClZXzsd{B5\W6xZ4Lh[pRm\CCvb4Xz[UBud2SnbDDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIT1cY9zKHKnZ4Lve5RpKGG2IHH0JFExKG2pL3vnMEBxdyB4MDDkZZl{KHCxc4SgeJJm[XSvZX70	NXz5PWN3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2OVQ1ODhpPkG5OlU1PDB6PD;hQi=>
MV4-11	NXi4VHEzSW62aYT1cY9zKGG\|c3H5	M4DTcVEhdWdxa3ev[IF6	M2PB[lMxKGSjeYO=	NVnNSlFTSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUXY1NTFzIHPlcIx{KHinbn;ndoFnfGWmIH3veZNmKGKxbnWgcYFzem:5IHXu[5Ji\nSvZX70JI1w\GWuIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI1wfXOnIHzp[oUhe3CjbjDheEAyKG2pL3vnM4RigSxicH:g[o9zKDNyIHThfZMhdWWjc4Xy[YQhd25iZHH5JFc4KHCxc4Sg[I9{\Q>?	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ3NESwPEc,OTl4NUS0NFg9N2F-
MV4-11	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M1KzVVczKGi{cx?=	NEezWY9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3WOE0yOSClZXzsd{Bi\nSncjC3NkBpenNiYomgZ4VtdCC2aYTldk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNE4xODB3NjFOwG0v	Mn\0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5NUSxPVkoRjF7N{W0NVk6RC:jPh?=
HEK293	MnzESpVv[3Srb36gZZN{[Xl?			NYnXSmpISmmwZHnu[{Bi\m[rbnn0fUB1dyCITGSzJINifGGueYTpZ{Bld22jaX6g[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBkd22yZYTpeIl3\SCkaX7kbY5oKGG\|c3H5MEBM\CB;IECuNFAyPiEQvF2u	NX7oRWdXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OVQyQTlpPkG5O\|U1OTl7PD;hQi=>
MV4-11	MkjDRY51cXS3bX;yJIF{e2G7	MXKxJI1oN2up	M3TESFI5KGSjeYO=	NIqyc4ZCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMhgGWwb3fyZYZ1\WRiaX6gZZRpgW2rYzDueYRmKG2xdYPlJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[geJVud3JiZ4Lve5RpKGG2IEGgcYcwc2duIIDvJHFFKG[xcjCyPEBl[Xm\|IH3lZZN2emWmIHT1dolv\yCmb4PpcocheGW{aX;k	NVLmXGJIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OVQyQTlpPkG5O\|U1OTl7PD;hQi=>
MV4-11	M37WWGFvfGm2dX3vdkBie3OjeR?=	MkfJN{Bu\y:tZx?=	Mm[zNlgh\GG7cx?=	MnzXRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTW[0MVEyKGOnbHzzJJhmdm:pcnHmeIVlKGmwIHH0bJlucWNiboXk[UBud3W\|ZTDhd5Nme3OnZDDhd{B1fW2xcjDndo94fGhicnXndoV{e2mxbjDheEA{KG2pL3vnMEBxdyCTRDDmc5IhOjhiZHH5d{Bu\WG\|dYLl[EBi\nSncjDkc5NqdmdicHXybY9l	NXTk[IhnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OVQyQTlpPkG5O\|U1OTl7PD;hQi=>
MV4-11	M13wXmFvfGm2dX3vdkBie3OjeR?=	NV3IZ\|FVOTBibXevb4c>	MnmzNlgh\GG7cx?=	NV:yWWl{SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUXY1NTFzIHPlcIx{KHinbn;ndoFnfGWmIHnuJIF1cHmvaXOgcpVl\SCvb4Xz[UBie3Onc4Pl[EBieyC2dX3vdkBoem:5dHigdoVoemW\|c3nvckBifCBzMDDt[{9s\yxicH:gVWQh\m:{IEK4JIRigXNibXXhd5Vz\WRiYX\0[ZIh\G:\|aX7nJJBmemmxZB?=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd3NEG5PUc,OTl5NUSxPVk9N2F-
MV4-11	NYPubWliSW62aYT1cY9zKGG\|c3H5	M3\MWVMhdWdxa3e=	MmDJNlgh\GG7cx?=	MXHBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPVkStNVEh[2WubIOgfIVvd2e{YX\0[YQhcW5iYYTofY1q[yCwdXTlJI1wfXOnIHHzd4V{e2WmIHHzJJN2eHC{ZYPzbY9vKG:oIIT1cY9zKH[xbIXt[UBifCB\|IH3nM4toNCCybzDRSEBnd3JiMkig[IF6eyCvZXHzeZJm\CCjZoTldkBld3OrbnegdIVzcW:m	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd3NEG5PUc,OTl5NUSxPVk9N2F-
MV4-11	M{KwRWFvfGm2dX3vdkBie3OjeR?=	MWGxNEBu\y:tZx?=	M4HRSVI5KGSjeYO=	MlrVRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTW[0MVEyKGOnbHzzJJhmdm:pcnHmeIVlKGmwIHH0bJlucWNiboXk[UBud3W\|ZTDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjD0eY1weiC4b3z1cYUh[XRiMUCgcYcwc2duIIDvJHFFKG[xcjCyPEBl[Xm\|IH3lZZN2emWmIHHmeIVzKGSxc3nu[{Bx\XKrb3S=	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd3NEG5PUc,OTl5NUSxPVk9N2F-
MV4-11	M4DPRmFvfGm2dX3vdkBie3OjeR?=	M3X0dlExKG2pL3vn	MYmyPEBl[Xm\|	M3[xdmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3WOE0yOSClZXzsd{B5\W6xZ4Lh[pRm\CCrbjDheIh6dWmlIH71[IUhdW:3c3WgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD0eY1weiCpcn;3eIgh[XRiMUCgcYcwc2duIIDvJHFFKG[xcjCyPEBl[Xm\|IH3lZZN2emWmIHHmeIVzKDN{IHThfZMheG:\|dHTvd4U>	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd3NEG5PUc,OTl5NUSxPVk9N2F-
MOLM13	NET4UmJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			NXnhe2xMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNU2xOOTNiY3XscJMh\XiycnXzd4lv\yCITGSzMWlVTCCvdYThcpQtKEeLNUCgQUAxNjByNDFOwG0v	NIDEWGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkeyOlk{OSd-MkK3NlY6OzF:L3G+
MV411	M2ToO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NUOx[XMxPDhiaILz	M3HWOGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1XPDFzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBZXFRiYYPzZZktKEeLNUCgQUA{NjNzIN88UU4>	NILhSJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUGwPFA4QSd-MkWxNFgxPzl:L3G+
THP1	MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NVXVUGdHPDhiaILz	MV3Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDUTHAyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDYWHQh[XO\|YYmsJGdKPTBiPTC1MlU4PCEQvF2u	NWPOXohkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWxNFgxPzlpPkK1NVA5ODd7PD;hQi=>
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Sf9	MXjGeY5kfGmxbjDhd5NigQ>?			Moq2TY5pcWKrdHnvckBw\iCQLYTldo1qdmGuIFfTWE9JcXN4LX\1d4VlKHKnY3;tZolv[W62IHj1cYFvKE[OVEOgLHI2PzFidH:gV\|k6OyC{ZYPp[JVmeyliSWTEJI12fGGwdDDlfJBz\XO\|ZXSgbY4hW2Z7IHnud4VkfCClZXzsd{B2e2mwZzDwc4x6KCiDbHGsS4x2NEy7czzUfZIqKDZ8Mkq1PlEhcHmmcn;ido9ucWSnIHHzJJN2[nO2cnH0[UBqdiCycnXz[Y5k\SCxZjDb[4FudWFvM{PQYWFVWCxiSVO1NEA:KDBwMEGg{txONg>?	M2LoRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkeyNFQ6Lz5{OU[3NlA1QTxxYU6=
Sf9	Mmf3SpVv[3Srb36gZZN{[Xl?			NE\sNnBKdmirYnn0bY9vKG:oIF6teIVzdWmwYXygS3NVN0irc{[t[pV{\WRicnXjc41jcW6jboSge4lt\CC2eYDlJIh2dWGwIF\MWFMhMFJ3N{GgeI8hWzl7MzDy[ZNq\HWnczmg[ZhxemW\|c3XkJIlvKFOoOTDpcpNm[3RiY3XscJMhfXOrbnegdI9tgSBqQXzhMGdtfSyOeYOsWJlzMSB4OkK6OVoyKGi7ZILvZpJwdWmmZTDhd{B{fWK\|dILheIUhcW5icILld4Vv[2Vib3[gX4didW2jLUOzVH1CXFBuIFnDOVAhRSByLkCzOkDPxE1w	NX\pNJR3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O\|IxPDlpPkK5OlczODR7PD;hQi=>
Kasumi-1	NEDZVHpIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MVe3NkBpenN?	MX;Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDLZZN2dWlvMTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[2GuY3XpckBCVSCmeXWtZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7LDDHTVUxKD1iMD6wOlQh\|ryPLh?=	MljvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{KwOFkoRjJ7NkeyNFQ6RC:jPh?=
Sf9	NVvt[mxoTnWwY4Tpc44h[XO\|YYm=			NV7ib4JvUW6qaXLpeIlwdiCxZjDOMZRmem2rbnHsJGdUXC:KaYO2MYZ2e2WmIILlZ49u[mmwYX70JIh2dWGwIF\MWFMhMFJ3N{GgeI8hWzl7MzDy[ZNq\HWnczmgSFg{PVlibYX0ZY51KGW6cILld5Nm\CCrbjDT[lkhcW6\|ZXP0JINmdGy\|IIXzbY5oKHCxbImgLGFt[SyJbIWsUJl{NFS7cjmgOlozQjV8MTDofYRzd2K{b33p[IUh[XNic4Xid5Rz[XSnIHnuJJBz\XOnbnPlJI9nKFupYX3tZU0{O1CfQWTQMEBKSzVyIE2gNE4yOzZizszNMi=>	MnfLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{KwOFkoRjJ7NkeyNFQ6RC:jPh?=
BA/F3	NGTINpVIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MkjuO\|IhcHK\|	MnfNS5Jwf3SqIHnubIljcXSrb36gc4YhdW:3c3WgRmEwTjNiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JINidGOnaX6gRW0h\HmnLXLhd4VlKG[udX;y[ZNk\W6lZTDhd5NigSxiR1m1NEA:KDFwNEWyJO69VS5?	MoK2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{KwOFkoRjJ7NkeyNFQ6RC:jPh?=
MV4-11	Mn[0SpVv[3Srb36gZZN{[Xl?	Mo\ONE4xOSC2bzCxNFAhdk1?	M4r3TFEhcHJ?	NYD0dYdYUW6qaXLpeIlwdiCxZjDGUHQ{KEmWRDDteZRidnRiaX6gbJVu[W5iTW[0MVEyKGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIFHLWEBxcG:\|cHjvdplt[XSrb36gZZQhWzR5MzDheEAxNjBzIITvJFExOCCwTTDh[pRmeiBzIHjyJIJ6KGmvbYXuc4Jtd3RiYX7hcJl{cXN?	M{DiO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkeyNFQ6Lz5{OU[3NlA1QTxxYU6=
MV4-11	NVLOcXN5TnWwY4Tpc44h[XO\|YYm=	M1PEelAvODFidH:gNVAxKG6P	MYqxJIhz	MV3Jcohq[mm2aX;uJI9nKE[OVEOgTXRFKG23dHHueEBqdiCqdX3hckBOXjRvMUGgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hVUWNMT:yJJBpd3OyaH;yfYxifGmxbjDheEBUOjF5L{KyNUBifCByLkCxJJRwKDFyMDDuUUBi\nSncjCxJIhzKGK7IHntcZVvd2Kub4SgZY5idHm\|aYO=	M123b\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkeyNFQ6Lz5{OU[3NlA1QTxxYU6=
MV4-11	M{P3[mZ2dmO2aX;uJIF{e2G7	MXuxJI5O	NXLWOoI4OSCqch?=	NHvUdWdKdmirYnn0bY9vKG:oIF\MWFMhUVSGIH31eIFvfCCjdYTvdIhwe3Cqb4L5cIF1cW:wIHH0JHk2QDlxNUmxJIlvKGi3bXHuJG1XPC1zMTDj[YxteyCjdDCxJI5OKGGodHXyJFEhcHJiYomgbY1ufW6xYnzveEBidmGueYPpdy=>	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ5MkC0PUc,Ojl4N{KwOFk9N2F-
MV4-11	MYnGeY5kfGmxbjDhd5NigQ>?	M2PGbVEhdk1?	MkPFNUBpeg>?	MnrtTY5pcWKrdHnvckBw\iCITGSzJGlVTCCvdYThcpQh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDZPFQzKGmwIHj1cYFvKE2YND2xNUBk\WyuczDheEAyKG6PIHHmeIVzKDFiaIKgZpkhcW2vdX7vZoxwfCCjbnHsfZNqew>?	M17zWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkeyNFQ6Lz5{OU[3NlA1QTxxYU6=
MV4-11	NHu5RZlHfW6ldHnvckBie3OjeR?=	NITySmIxNjBzIITvJFExOCCwTR?=	MnG3NUBpeg>?	NIXpcHpKdmirYnn0bY9vKG:oIF\MWFMhUVSGIH31eIFvfCCrbjDoeY1idiCPVkStNVEh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iU2TBWFUheGixc4Doc5J6dGG2aX;uJIF1KFl4OUSgZZQhOC5yMTD0c{AyODBibl2gZYZ1\XJiMTDodkBjgSCrbX31co9jdG:2IHHuZYx6e2m\|	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ5MkC0PUc,Ojl4N{KwOFk9N2F-
MV4-11	MUfGeY5kfGmxbjDhd5NigQ>?	MlfMNE4xOSC2bzCxNFAhdk1?	MWWxJIhz	MW\Jcohq[mm2aX;uJI9nKE[OVEOgTXRFKG23dHHueEBqdiCqdX3hckBOXjRvMUGgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hTVKNMT:yJJBpd3OyaH;yfYxifGmxbjDheEBVOjB{L2myNFQh[XRiMD6wNUB1dyBzMECgcm0h[W[2ZYKgNUBpeiCkeTDpcY12dm:kbH;0JIFv[Wy7c3nz	MnPNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{KwOFkoRjJ7NkeyNFQ6RC:jPh?=
MV4-11	NYf3OWtFTnWwY4Tpc44h[XO\|YYm=	NXvJbY1zOTBibXevb4c>	MYCyOEBpenN?	NVzv[Y5LUW5idnn2c{BqdmirYnn0bY9vKG:oIF\MWFMhUVSGIH31eIFvfCCrbjDoeY1idiCPVkStNVEh[2WubIOgfIVvd2e{YX\0[YQhcW5iYYTofY1q[yCwdT;ueUBud3W\|ZTDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCVVFHUOUBxcG:\|cHjvdplt[XSrb36gZZQhYTZ7NDDheEAyOCCvZz;r[{whcXBiYX\0[ZIhOjRiaILzJIJ6KGmvbYXuc4Jtd3RibXX0bI9lKHKnbHH0bZZmKHSxIHPvcpRzd2x?	MoD3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{KwOFkoRjJ7NkeyNFQ6RC:jPh?=
MV4-11	M2LkO2Z2dmO2aX;uJIF{e2G7	MkPFNE4yKHWP	M17SPFQhcHK\|	M{T5VGlvcGmkaYTpc44hd2ZiRlzUN{BqdiCqdX3hckBOXjRvMUGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKEGNVDDwbI9{eGixconsZZRqd25iYYSgV4VzPDd\|IILld4llfWViYYSgNE4yKHWPIHHmeIVzKDRiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?=	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTh7NEm0OEc,Ojl6OUS5OFQ9N2F-
MV4-11	Moe1SpVv[3Srb36gZZN{[Xl?	M2G5eVAvOSC3TR?=	NHzxOJg1KGi{cx?=	MWDJcohq[mm2aX;uJI9nKE[OVEOgbY4hcHWvYX6gUXY1NTFzIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBUXEGWNTDwbI9{eGixconsZZRqd25iYYSgWJlzPjl2IILld4llfWViYYSgNE4yKHWPIHHmeIVzKDRiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?=	M4iwWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OEm0PVQ1Lz5{OUi5OFk1PDxxYU6=
MV4-11	M2XNXGZ2dmO2aX;uJIF{e2G7	MnnWNE4yKHWP	NXjVOnhyPCCqcoO=	MUjJcohq[mm2aX;uJI9nKE[OVEOgbY4hcHWvYX6gUXY1NTFzIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBGWktzL{KgdIhwe3Cqb4L5cIF1cW:wIHH0JHRpejJyMj;UfZIzODRicnXzbYR2\XNiYYSgNE4yKHWPIHHmeIVzKDRiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?=	M3HFWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OEm0PVQ1Lz5{OUi5OFk1PDxxYU6=
MV4-11	MVXGeY5kfGmxbjDhd5NigQ>?	M3v2eVAvOSC3TR?=	M1fq[VQhcHK\|	NG\vdmZKdmirYnn0bY9vKG:oIF\MWFMheGixc4Doc5J6dGG2aX;uJIF1KFS7ckW4PU82QTFicnXzbYR2\XNiaX6gbJVu[W5iTW[0MVEyKGOnbHzzJIF1KDBwMTD1UUBi\nSncjC0JIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM>	NG\LNHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUi5OFk1PCd-Mkm4PVQ6PDR:L3G+

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	phospho-FLT3 / FLT3; PubMed: 22875611 Haematologica (B) The same cells were also harvested for Western blot analysis after treatment for 90 min with different concentrations of AC220. The phosphorylation of the different FLT3 proteins was determined using a phospho-FLT3 antibody. p-STAT5 / STAT5 / β-catenin / p-AKT / AKT / p-ERK / ERK / p-S6 / S6; PubMed: 28625976 Cancer Res Western blot analysis of AC220 treated MV4-11 cells. Cells were starved for overnight and treated with AC220 at indicated concentrations. Cells were harvested after 2 hours treatment and lysed. Then western blots analysis was performed. The quantification of bands are shown below the gel.	22875611 28625976
Immunofluorescence	WGA / FLT3 ; PubMed: 28895560 Leukemia Immunofluorescence staining of FLT3-WT, FLT3 mutants or empty vector with or without AC220 treatment in transiently transfected U2OS cells. WGA (wheat germ agglutinin). Scale bar: 25 μm.	28895560
Growth inhibition assay	Cell viability; PubMed: 23967177 PLoS One K562/ABCB1 and K562/ABCG2 cells exhibit collateral sensitivity toquizartinib. K562, K562/ABCB1 and K562/ABCG2 cells were plated in the presence of quizartinib in increasing concentrations for 96 hours and viable cells were measured using the WST-1 assay.	23967177

体内研究

AC220作用于移植瘤模型，具有好的药品属性，极高的药效和耐受性。在体内，AC220作用于FLT3-ITD AML鼠模型，抑制FLT3活性,明显延长寿命；作用于依赖FLT3的移植瘤鼠模型时，根除肿瘤；作用于病人原代细胞时，有效抑制FLT3活性。^[1]

激酶实验：^[1]	- 合并激酶实验: 为了测定AC220抑制无靶点激酶的效果，为了比较AC220和其他FLT抑制剂的选择性,使AC220作用于KinomeScan一组402种激酶进行结合试验，其中80%为典型的人类蛋白激酶。测定所有激酶的解离常数。计算绝对选择性和作用于FLT的相对选择性。
细胞实验：^[1]	- 合并 Cell lines: MV4-11和RS4;11细胞 Concentrations: 0-100 nM Incubation Time: 72小时，及2小时 Method: 在增殖实验中，细胞培养在低血清培养基(含0.5% FBS)中过夜, 然后按每孔4×10⁴个细胞接种在96孔板上，然后加入AC220，37^oC下温育72小时。测定细胞活力。测定抑制FLT3自磷酸化的效果, 细胞培养在低血清培养基(含0.5% FBS)过夜，然后按每孔4×10⁵个细胞接种在96孔板上。细胞和AC220一起在37^oC下温育2小时，诱导 RS4;11细胞中FLT3自磷酸化, 加入100 ng/mL FLT3配位体，持续15分钟。转移细胞溶解物到用FLT3抗体包被的96孔板上。然后加入作用于FLT3的生物素化抗体，测定全部FLT3，或者作用于磷酸酪氨酸的抗体，测定FLT3自磷酸化。使用 SULFO标记的链霉亲和素二抗进行电化学发光测定。 (Only for Reference)
动物实验：^[1]	- 合并 Animal Models: 雌性裸鼠或严重联合免疫缺陷鼠 Dosages: 10 mL/kg Administration: 口服饲喂处理 (Only for Reference)

参考文献

[1] Zarrinkar PP, et al. Blood, 2009, 114(14), 2984-2992.

溶解度 (25°C)

体外	DMSO	33 mg/mL (58.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 15% Captisol	30 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Quizartinib (AC220) SDF

分子量	560.67
化学式	C₂₉H₃₂N₆O₄S
CAS号	950769-58-1
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04459598	Completed	Drug: Efavirenz\|Drug: Quizartinib	Healthy Subjects\|Drug-drug Interaction\|Pharmacokinetics\|Quizartinib	Daiichi Sankyo Co. Ltd.\|Daiichi Sankyo Inc.	September 8 2020	Early Phase 1
NCT04473664	Completed	Drug: Quizartinib	Hepatic Impairment\|Moderate Impaired Hepatic Function	Daiichi Sankyo Co. Ltd.\|Daiichi Sankyo Inc.	September 29 2020	Phase 1
NCT04459585	Completed	Drug: Dabigatran Etexilate Mesylate\|Drug: Quizartinib	Healthy Subjects\|Drug-drug Interaction\|Pharmacokinetics\|Quizartinib	Daiichi Sankyo Co. Ltd.\|Daiichi Sankyo Inc.	August 28 2020	Early Phase 1
NCT04209725	Terminated	Drug: CPX-351\|Drug: Quizartinib	Leukemia Myeloid Acute	SCRI Development Innovations LLC	June 3 2020	Phase 2

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操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
Is it possible to alter the captisol concentration to make it more dissolvable i.e 20% or 25% captisol ?
回答：
In 15% Captisol, the compound forms s suspension at 30mg/ml. Increasing the percentage of Captisol will not convert the mixture into solution. You can use suspension for oral gavage feeding.

Target Protein Ligand Inhibitors with Unique Features

用于临床的FLT3抑制剂

Dovitinib (TKI-258, CHIR-258) : Phase III for Metastatic Renal Cell Carcinoma.

研究领域

产品类型

定制您的化合物库

Quizartinib (AC220)

客户使用Selleck生产的Quizartinib (AC220)发表文献94篇：

产品安全说明书

Target Protein Ligand抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Quizartinib (AC220) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-09-06)

技术支持

常见问题及建议解决方法

Target Protein Ligand Inhibitors with Unique Features