Quizartinib (AC220)

For research use only. Not for use in humans.

目录号：S1526 中文名称：奎扎替尼

CAS No. 950769-58-1

Quizartinib (AC220)是一种二代FLT3抑制剂，作用于Flt3(ITD/WT)，在MV4-11和 RS4;11细胞中IC50分别为1.1 nM/4.2 nM，作用于Flt3比作用于KIT，PDGFRA，PDGFRB，RET，和CSF-1R选择性高10倍。Quizartinib (AC220)可诱导肿瘤细胞的凋亡。Phase 3。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 2891.02	现货
5mg	RMB 1729.76	现货
50mg	RMB 7933.51	现货
200mg	RMB 20229.3	现货
大包装	有超大折扣

大剂量询单有大折扣!

今日订购，明日送达，全国免运费！

全国免费电话：400-668-6834 | Email：info@selleck.cn

客户使用Selleck生产的Quizartinib (AC220)发表文献74篇：

Cancer Cell, 2018, 34(2):315-330

PubMed: 30033091 ( click the link to review the publication )

Nat Med, 2017, 23(1):69-78

PubMed: 27941792 ( click the link to review the publication )

Drug Metab Dispos, 2021, 49(1):53-61

PubMed: 33148688 ( click the link to review the publication )

Cell Rep, 2020, 33(1):108221

PubMed: 33027668 ( click the link to review the publication )

Haematologica, 2020, 15 pii: haematol 2019 244020

PubMed: 32414851 ( click the link to review the publication )

Mol Cell Proteomics, 2020, 10.1074/mcp.RA119.001504

PubMed: 32102969 ( click the link to review the publication )

Eur J Med Chem, 2020, 193:112232

PubMed: 32199135 ( click the link to review the publication )

J Cell Mol Med, 2020, 24(3):2308-2318

PubMed: 31881122 ( click the link to review the publication )

J Cell Mol Med, 2020, 25

PubMed: 32450611 ( click the link to review the publication )

Sci Rep, 2020, 10(1):16187

PubMed: 32999332 ( click the link to review the publication )

Sci Rep, 2020, 10(1):1906

PubMed: 32024878 ( click the link to review the publication )

Transl Oncol, 2020, 1;13(4):100766

PubMed: 32247263 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00420-z

PubMed: 32870449 ( click the link to review the publication )

Pharmacol Res, 2020, 151:104556

PubMed: 31778791 ( click the link to review the publication )

FEBS Open Bio, 2020, 10.1002/2211-5463.12827

PubMed: 32128992 ( click the link to review the publication )

Cancer Cell, 2020, 38(6):872-890.e6

PubMed: 33217342 ( click the link to review the publication )

Sci Transl Med, 2019,

PubMed: 31484791 ( click the link to review the publication )

Autophagy, 2019, 15(9):1558-1571

PubMed: 30821613 ( click the link to review the publication )

Cell Rep, 2019, 28(9):2331-2344

PubMed: 31461650 ( click the link to review the publication )

Cancer Discov, 2019, 9(6):756-777

PubMed: 30862724 ( click the link to review the publication )

Int J Mol Sci, 2019, 20(19)

PubMed: 31554189 ( click the link to review the publication )

Theriogenology, 2019, 126:145-152

PubMed: 30553232 ( click the link to review the publication )

Cell Rep, 2019, 26(11):2916-2928.e13

PubMed: 30865883 ( click the link to review the publication )

FEBS Lett, 2019, 593(16):2162-2176

PubMed: 31135968 ( click the link to review the publication )
Hemasphere, 2019, 3(2):e182

PubMed: 31723821 ( click the link to review the publication )

Oncotarget, 2019, 10(58):6111-6123

PubMed: 31692922 ( click the link to review the publication )

Blood, 2018, 25;131(4):426-438

PubMed: 29187377 ( click the link to review the publication )

Blood, 2018, 132(1):67-77.

PubMed: 29784639 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(7):1716-1726

PubMed: 29330206 ( click the link to review the publication )

Leukemia, 2018, 32(2):313-322

PubMed: 28895560 ( click the link to review the publication )

Haematologica, 2018, haematol.2018.189399

PubMed: 29748445 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(10):2417-2429

PubMed: 29463558 ( click the link to review the publication )

Oncogene, 2018, 37(6):787-797

PubMed: 29059168 ( click the link to review the publication )

Cell Death Dis, 2018, 9(2):138

PubMed: 29374185 ( click the link to review the publication )

Neoplasia, 2018, 20(1):1-11

PubMed: 29172076 ( click the link to review the publication )

Nephrol Dial Transplant, 2018, 10.1093/ndt/gfy385

PubMed: 30590794 ( click the link to review the publication )

PLoS One, 2018, 13(5):e0196805

PubMed: 29723246 ( click the link to review the publication )

Exp Hematol, 2018, 58:52-58

PubMed: 28947392 ( click the link to review the publication )

J Ophthalmol, 2018, 2018:2518568

PubMed: 29854425 ( click the link to review the publication )

Oncotarget, 2018, 9(76):34240-34258

PubMed: 30344940 ( click the link to review the publication )

Leukemia, 2018, 32(11):2374-2387

PubMed: 29743719 ( click the link to review the publication )

Oncotarget, 2018, 9(24):16917-16931

PubMed: 29682194 ( click the link to review the publication )

Blood, 2017, 130(1):48-58

PubMed: 28490572 ( click the link to review the publication )

Leukemia, 2017, 31(11):2336-2346

PubMed: 28280274 ( click the link to review the publication )

Cancer Res, 2017, 77(7):1697-1708

PubMed: 28108507 ( click the link to review the publication )

Leuk Lymphoma, 2017, 10.1080/10428194.2017.1289522

PubMed: 28276286 ( click the link to review the publication )

Blood Adv, 2017, 1(20):1635-1644

PubMed: 29296810 ( click the link to review the publication )

Oncotarget, 2017, 8(32):52026-52044

PubMed: 28881711 ( click the link to review the publication )
Blood, 2016, 127(23):2890-902

PubMed: 27099147 ( click the link to review the publication )

Cancer Res, 2016, 76(6):1528-37

PubMed: 26822154 ( click the link to review the publication )

Cancer Res, 2016, 76(5):1214-24

PubMed: 26833125 ( click the link to review the publication )

Sci Rep, 2016, 6:28032

PubMed: 27346558 ( click the link to review the publication )

Ann Hematol, 2016, 95(5):783-91

PubMed: 26891877 ( click the link to review the publication )

PLoS One, 2016, 11(7):e0158290

PubMed: 27387666 ( click the link to review the publication )

Int J Hematol, 2016, 103(1):95-106

PubMed: 26590920 ( click the link to review the publication )

Leukemia, 2015, 29(12):2382-9

PubMed: 26172401 ( click the link to review the publication )

Leukemia, 2015, 29(12):2390-2

PubMed: 26108694 ( click the link to review the publication )

Leukemia, 2015, 29(4):828-38

PubMed: 25322685 ( click the link to review the publication )

Oncotarget, 2015, 6(35):38061-78

PubMed: 26515730 ( click the link to review the publication )

Sci Adv, 2015, 1(8):e1500221

PubMed: 26601252 ( click the link to review the publication )

Blood, 2014, 123(18):2826-37

PubMed: 24668492 ( click the link to review the publication )

Blood, 2014, 123(5):734-42

PubMed: 24282218 ( click the link to review the publication )

Nat Commun, 2014, 5:3672

PubMed: 24739485 ( click the link to review the publication )

Clin Cancer Res, 2014, 20(8):2092-103

PubMed: 24436473 ( click the link to review the publication )

Leukemia, 2014, 28(11):2197-205

PubMed: 24699302 ( click the link to review the publication )

Leukemia, 2014, 28(2):293-301

PubMed: 23748345 ( click the link to review the publication )

Proc Natl Acad Sci USA, 2014, 10.1073/pnas.1320661111

PubMed: 24623852 ( click the link to review the publication )

Cancer Discov, 2014, 4(2):200-15

PubMed: 24362263 ( click the link to review the publication )

Mol Cancer Ther, 2014, 13(10):2315-27

PubMed: 25053825 ( click the link to review the publication )

J Biol Chem, 2014, 289(45):31053-65

PubMed: 25237195 ( click the link to review the publication )

PLoS One, 2013, 8(8): e71266

PubMed: 23967177 ( click the link to review the publication )

PLoS One, 2013, 8(9):e74653

PubMed: 24040307 ( click the link to review the publication )
Leuk Res, 2013, 37(11):1557-64

PubMed: 23998902 ( click the link to review the publication )

Br J Pharmacol, 2012, 166(3):858-76

PubMed: 22250956 ( click the link to review the publication )

产品安全说明书

Target Protein Ligand抑制剂选择性比较

生物活性

产品描述

特性

AC220是二代FLT3抑制剂，且作为临床FLT3抑制剂的第一候选药。

靶点

FLT3 (ITD) ^[1] (MV4-11 cells)	FLT3 (WT) ^[1] (RS4;11 cells)
1.1 nM	4.2 nM

体外研究

AC220是最有效的FLT3选择性抑制剂，可用于治疗急性骨髓性白血病(AML)。AC220在生化和细胞实验中具有低纳摩尔效果和特别的激酶选择性，抑制大部分人类蛋白激酶时具有高选择性。AC220是治疗急性骨髓性白血病(AML)的新型FLT3抑制剂。^[1]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
HL60/VCR	NVq5d4hLTnWwY4Tpc44hSXO\|YYm=	MkjvNE4yNTFyIN88US=>	MlLFN\|AhdWmw	NXP4NJlz\W6qYX7j[ZMhfXC2YXvlJI9nKHO3YoP0doF1\XNib3[gRWJETzJiYX7kJGFDS0JzIHnuJIEh[2:wY3XueJJifGmxbj3k[ZBmdmSnboSgcYFvdmW{	Mn3aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NkexO\|coRjJ\|OU[3NVc4RC:jPh?=
K562/ABCB1	M{i1fGZ2dmO2aX;uJGF{e2G7	MWKwMlEuOTBizszN	MnywN\|AhdWmw	NIHaPZdmdmijbnPld{B2eHSja3Wgc4Yhe3Wkc4TyZZRmeyCxZjDBRmNIOiCjbnSgRWJESjFiaX6gZUBkd26lZX70doF1cW:wLXTldIVv\GWwdDDtZY5v\XJ?	NG\DflM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2O\|E4Pyd-MkO5OlcyPzd:L3G+
8226/MR20	NHLaO2dHfW6ldHnvckBCe3OjeR?=	NH7uW\|MxNjFvMUCg{txO	M2rEOlMxKG2rbh?=	MUPlcohidmOnczD1dJRic2Vib3[gd5Vje3S{YYTld{Bw\iCDQlPHNkBidmRiQVLDRlEhcW5iYTDjc45k\W62cnH0bY9vNWSncHXu[IVvfCCvYX7u[ZI>	NGPITXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2O\|E4Pyd-MkO5OlcyPzd:L3G+
K562/ABCG2	NFrmd\|FHfW6ldHnvckBCe3OjeR?=	Mn:xNE4yNTFyIN88US=>	NHL6R4w{OCCvaX6=	NWf1XWJP\W6qYX7j[ZMhfXC2YXvlJI9nKHO3YoP0doF1\XNib3[gRWJETzJiYX7kJGFDS0JzIHnuJIEh[2:wY3XueJJifGmxbj3k[ZBmdmSnboSgcYFvdmW{	NV;E[oFNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OlcyPzdpPkKzPVY4OTd5PD;hQi=>
MCF-7 FLV1000	Ml3ET4lv[XOnIFHzd4F6	MmjxNQKBmzNyINM1US=>	Mkm2OUBucW5?	MUHk[YNz\WG\|ZYOgX\|EzPUmfLVnBRXAheGixdH;sZYJmdGmwZzDv[kBCSkOEMTDheEBKSzVyIH;mJFMvOyEQvF2=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl4N{G3O{c,OjN7NkexO\|c9N2F-
MCF-7 FLV1000	M2\rXmtqdmG\|ZTDBd5NigQ>?	NWjNdXJROOLCk{OwJOK2VQ>?	NFm4ZmU2KG2rbh?=	NEiwXHNl\WO{ZXHz[ZMhYzF{NVndMWlCSVBicHjveI9t[WKnbHnu[{Bw\iCDQlPCNkBifCCLQ{WwJI9nKDBwMEeg{txO	NHTJVY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2O\|E4Pyd-MkO5OlcyPzd:L3G+
K562/ABCG2	MWXD[YxtKF[rYXLpcIl1gSCDc4PhfZM>	NXfB[GQxOC5zL{CuOU8yKML3TR?=	NIj2Nos6PiCq	MXXz[Y5{cXSrenXzJGs2PjJxQVLDS\|Ih[2WubIOgeI8hdWm2b4jhcpRzd26nIITvdI91\WOjbtMg	NGWwNY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2O\|E4Pyd-MkO5OlcyPzd:L3G+
8226/MR20	MkDMR4VtdCCYaXHibYxqfHliQYPzZZl{	M{nYWVAvOSEEtV2=	M2T1V\|k3KGh?	M3\NdZNmdnOrdHn6[ZMhUzV4Mj;BRmNIOiClZXzsd{B1dyCvaYTvfIFvfHKxbnWgeI9xd3SnY3HuxsA>	M3jnZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OU[3NVc4Lz5{M{m2O\|E4PzxxYU6=
HMC1.1	NVTwXIZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NH;1SHlKSzVyPUG0JI5O	Mn;YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUezNVcoRjJ\|NEm3N\|E4RC:jPh?=
HMC1.2	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NW\NOlh5UUN3ME2xO\|I4KG6P	NYHtdVh4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVc{OTdpPkKzOFk4OzF5PD;hQi=>
p815	NWXwTmRFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MUnJR\|UxRTR2NTDuUS=>	M{\qO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEm3N\|E4Lz5{M{S5O\|MyPzxxYU6=
Kasumi-1	NWiwVJc2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NXLMcoJCUUN3ME2zOkBvVQ>?	NHrVV4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5O\|MyPyd-MkO0PVc{OTd:L3G+
M-07e + SCF	MorxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M2nlUWlEPTB;N{egcm0>	M2j3eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEm3N\|E4Lz5{M{S5O\|MyPzxxYU6=
EOL-1	NUXzSGtIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NHTQRmNKSzVyPUGgcm0>	MkWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUezNVcoRjJ\|NEm3N\|E4RC:jPh?=
MV4;11	M3rzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NHn6RYhKSzVyPDCxJI5O	Moe1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUezNVcoRjJ\|NEm3N\|E4RC:jPh?=
MOLM14	NUTNVWx6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MmfjTWM2ODxiMTDuUS=>	MkH0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUezNVcoRjJ\|NEm3N\|E4RC:jPh?=
Pat.221	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MoLrTWM2OD14N{Wgcm0>	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR7N{OxO{c,OjN2OUezNVc9N2F-
Pat.279	NWfCTopUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M2mxZ2lEPTB;M{SzOEBvVQ>?	M2rFW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEm3N\|E4Lz5{M{S5O\|MyPzxxYU6=
Pat.299	M1;6VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NWGyS2E6UUN3ME23NlQ5KG6P	NX;4UXA1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVc{OTdpPkKzOFk4OzF5PD;hQi=>
Pat.305	MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M1P1VWlEPTB;N{C3PUBvVQ>?	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR7N{OxO{c,OjN2OUezNVc9N2F-
Pat.375	NWe0bVd[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3PF[2lEPTB;NUCzJI5O	MmjsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUezNVcoRjJ\|NEm3N\|E4RC:jPh?=
Pat.379	MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NEiye\|FKSzVyPUiwOkBvVQ>?	NVfuVot2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVc{OTdpPkKzOFk4OzF5PD;hQi=>
Pat.368	NIHuboJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MkL2TWM2OD1{N{CwJI5O	M3\Ie\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEm3N\|E4Lz5{M{S5O\|MyPzxxYU6=
Pat.601	M3LM[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MmDwTWM2OD1zMUWzJI5O	M{ize\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEm3N\|E4Lz5{M{S5O\|MyPzxxYU6=
HMC1.1	NGLEUVhCeG:ydH;zbZMhSXO\|YYm=			MWjJR\|UxRTNzIH7N	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR7N{OxO{c,OjN2OUezNVc9N2F-
p815	Mnm5RZBweHSxc3nzJGF{e2G7			M1Lwe2lEPTB;M{SxJI5O	NInZfFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5O\|MyPyd-MkO0PVc{OTd:L3G+
Kasumi-1	MVjBdI9xfG:\|aYOgRZN{[Xl?			NY[xW4Q1UUN3ME22O{BvVQ>?	MoTRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUezNVcoRjJ\|NEm3N\|E4RC:jPh?=
M-07e + SCF	NUDCSYFSSXCxcITvd4l{KEG\|c3H5			M3ruN2lEPTB;N{igcm0>	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR7N{OxO{c,OjN2OUezNVc9N2F-
EOL-1	NXrSTG5DSXCxcITvd4l{KEG\|c3H5			MWPJR\|UxRCBzIH7N	NVfVN2FXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVc{OTdpPkKzOFk4OzF5PD;hQi=>
MV4;11	MXvBdI9xfG:\|aYOgRZN{[Xl?			MYfJR\|UxRTJibl2=	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR7N{OxO{c,OjN2OUezNVc9N2F-
MOLM14	NGLJd\|lCeG:ydH;zbZMhSXO\|YYm=			MojiTWM2OD1\|IH7N	NYju[\|NxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVc{OTdpPkKzOFk4OzF5PD;hQi=>
GIST822	NHm4fnJCeG:ydH;zbZMhSXO\|YYm=			NWCwPFZTUUN3ME2xNFkhdk1?	NFXqcZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5O\|MyPyd-MkO0PVc{OTd:L3G+
Pat.368	MUTBdI9xfG:\|aYOgRZN{[Xl?			NILKOmhKSzVyPUK5PVghdk1?	NYjXVphtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVc{OTdpPkKzOFk4OzF5PD;hQi=>
Pat.601	MW\BdI9xfG:\|aYOgRZN{[Xl?			NH;tSGxKSzVyPUi3OkBvVQ>?	NFSwV4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5O\|MyPyd-MkO0PVc{OTd:L3G+
MV4-11	M2HSSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M4Tze\|czKGh?	MojmTWM2OD1yLkOgcm0>	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzMkmzNUc,OjN2MUK5N\|E9N2F-
MOLM-14	MmTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MWi3NkBp	MkPFTWM2OD1yLkGgcm0>	NVHtR3M6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVI6OzFpPkKzOFEzQTNzPD;hQi=>
SEM-K2	NIL3OlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NXnMRZljPzJiaB?=	M4\xUWlEPTB;MD60JI5O	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzMkmzNUc,OjN2MUK5N\|E9N2F-
RS4;11	MmPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NF:wNFM4OiCq	NVXZUmZKUUN3ME6xNEwxODBibl2=	NGLvUoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxNlk{OSd-MkO0NVI6OzF:L3G+
THP-1	M3S3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVzNRZA{PzJiaB?=	M{GxT2lEPTB-MUCsNFAxKG6P	M{T4XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEGyPVMyLz5{M{SxNlk{OTxxYU6=
MV4-11	MlfuRZBweHSxc3nzJGF{e2G7		Ml\DPE8zPCCq	NIH3fmVqdmS3Y3XzJJNq\26rZnnjZY51KGGwZDDkc5NmNWSncHXu[IVvfCCSQWLQJINt\WG4YXflJIFv\CCjY3P1cZVt[XSrb36gc4Yhe3WkLULOJGRPSQ>?	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzMkmzNUc,OjN2MUK5N\|E9N2F-
MOLM-14	NXztdHc{SXCxcITvd4l{KEG\|c3H5		NFHJeFI5NzJ2IHi=	MlWybY5lfWOnczDzbYdvcW[rY3HueEBidmRiZH;z[U1l\XCnbnTlcpQhWEGUUDDjcIVifmGpZTDhcoQh[WOldX31cIF1cW:wIH;mJJN2[i1{TjDEUmE>	M3\ZU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEGyPVMyLz5{M{SxNlk{OTxxYU6=
SEM-K2	NETX[4NCeG:ydH;zbZMhSXO\|YYm=		MYG4M\|I1KGh?	MoC3bY5lfWOnczDzbYdvcW[rY3HueEBidmRiZH;z[U1l\XCnbnTlcpQhWEGUUDDjcIVifmGpZTDhcoQh[WOldX31cIF1cW:wIH;mJJN2[i1{TjDEUmE>	NXTCZmxDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVI6OzFpPkKzOFEzQTNzPD;hQi=>
AML	NVvP[nhFS3m2b4TvfIlkcXS7IHHzd4F6			MlHDR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRW1NKGOnbHzzJIl{d2yjdHXkJIZzd21icnXsZZB{\WRiYXP1eIUhdXmnbH;p[EBt\XWtZX3pZUBx[XSrZX70JIhiemKxcnnu[{BHVFR\|IFnUSEBufXSjdHnvckBjgSCPVGSgZZN{[XluIFnDOVAhRSByLkCwNFMh\|ryPLh?=	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ3NESwPEc,OTl4NUS0NFg9N2F-
MV4-11	M4LxXmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MlGyO\|IhcHK\|	NYrnXmQxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVVZ2LUGxJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSClZXzsJJRqfGW{LXLseYUh[XO\|YYmsJGlEPTBiPTCwMlAxODV4IN88UU4>	NE\Rb5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[1OFQxQCd-MUm2OVQ1ODh:L3G+
blast cells	MUPGeY5kfGmxbjDhd5NigQ>?		NFzOV2QzKGi{cx?=	NFfXVnNKdmirYnn0bY9vKG:oIF\MWFMhUVSGIH31eIFvfCCjdYTvdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIHLsZZN1KGOnbHzzJIFnfGW{IEKgbJJ{KGK7IHXs[YN1em:laHXtbYx2dWmwZYPj[Y5k\SxiSVO1NEA:KDBwMECwPEDPxE1w	MnXEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4NUS0NFgoRjF7NkW0OFA5RC:jPh?=
RS4-11	NIrOeVZHfW6ldHnvckBie3OjeR?=		Mlv0NkBpenN?	M1HVbmlvcGmkaYTpc44hd2ZiRlzUN{BKXERibYX0ZY51KGG3dH;wbI9{eGixconsZZRqd25iaX6gbJVu[W5iUmO0MVEyKGOnbHzzJIFnfGW{IEKgbJJ{KGK7IHXs[YN1em:laHXtbYx2dWmwZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvODBzMTFOwG0v	M1jsdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkW0OFA5Lz5zOU[1OFQxQDxxYU6=
AML	M4fSRmZ2dmO2aX;uJIF{e2G7			NF\S[nBKdmirYnn0bY9vKG:oIF\MWFMh[XW2b4Doc5NxcG:{eXzheIlwdiCrbjDoeY1idiCDTVygZ4VtdHNiaYPvcIF1\WRiZoLvcUBz\WyjcIPl[EBi[3W2ZTDtfYVtd2mmIHzleYtmdWmjIIDheIlmdnRiYomgW4V{fGW{bjDicI91fGmwZzygTWM2OCB;IECuNFAzKM7:TT6=	M{nNVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkW0OFA5Lz5zOU[1OFQxQDxxYU6=
RS4-11	NGPKbHlHfW6ldHnvckBie3OjeR?=		NEK0c5AzKGi{cx?=	MWLJcohq[mm2aX;uJI9nKE[OVEOgZZV1d3Cqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBTWzRvMUGgZ4VtdHNiYX\0[ZIhOiCqcoOgZpkh\WynY4Tyc4Np\W2rbIXtbY5me2OnbnPlJIF{e2G7LDDJR\|UxKD1iMD6wNFQzKM7:TT6=	MkfUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4NUS0NFgoRjF7NkW0OFA5RC:jPh?=
MV4-11	MnHvRY51cXS3bX;yJIF{e2G7	NHz6eG4yOCCvZz;r[y=>	MY[2NEBl[Xm\|	NGLZXlZCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMhgGWwb3fyZYZ1\WRibX;1d4UhdW:mZXygZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjD0eY1weiC{ZXfyc5d1cCCjdDDheEAyOCCvZz;r[{wheG9iNkCg[IF6eyCyb4P0JJRz\WG2bXXueC=>	MlzrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4NUS0NFgoRjF7NkW0OFA5RC:jPh?=
MV4-11	MlzRRY51cXS3bX;yJIF{e2G7	M3PVPFEhdWdxa3ev[IF6	M361PFMxKGSjeYO=	M4TmVWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3WOE0yOSClZXzsd{B5\W6xZ4Lh[pRm\CCvb4Xz[UBjd26nIH3hdpJwfyCnbnfyZYZ1dWWwdDDtc4RmdCCjc4Pld5Nm\CCjczDpcoNz\WG\|ZTDtc5V{\SCuaX\lJJNx[W5iYYSgNUBu\y:tZz;kZZktKHCxIH\vdkA{OCCmYYnzJI1m[XO3cnXkJI9vKGSjeTC3O{Bxd3O2IHTvd4U>	NEP0e4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[1OFQxQCd-MUm2OVQ1ODh:L3G+
MV4-11	MV\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NYDlUnhGPzJiaILz	MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2YND2xNUBk\WyuczDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMD6wNFA2PiEQvF2u	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd3NEG5PUc,OTl5NUSxPVk9N2F-
HEK293	MmHaSpVv[3Srb36gZZN{[Xl?			NVy5TXhrSmmwZHnu[{Bi\m[rbnn0fUB1dyCITGSzJINifGGueYTpZ{Bld22jaX6g[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBkd22yZYTpeIl3\SCkaX7kbY5oKGG\|c3H5MEBM\CB;IECuNFAyPiEQvF2u	NWnvcYF3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OVQyQTlpPkG5O\|U1OTl7PD;hQi=>
MV4-11	MWjBcpRqfHWvb4KgZZN{[Xl?	NGHa[GQyKG2pL3vn	M2Tw[FI5KGSjeYO=	NF;QXWhCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMhgGWwb3fyZYZ1\WRiaX6gZZRpgW2rYzDueYRmKG2xdYPlJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[geJVud3JiZ4Lve5RpKGG2IEGgcYcwc2duIIDvJHFFKG[xcjCyPEBl[Xm\|IH3lZZN2emWmIHT1dolv\yCmb4PpcocheGW{aX;k	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd3NEG5PUc,OTl5NUSxPVk9N2F-
MV4-11	NGPnW5FCdnSrdIXtc5Ih[XO\|YYm=	M4XlW\|MhdWdxa3e=	MYGyPEBl[Xm\|	NFT6[lNCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMhgGWwb3fyZYZ1\WRiaX6gZZRpgW2rYzDueYRmKG2xdYPlJIF{e2W\|c3XkJIF{KHS3bX;yJIdzd3e2aDDy[Ydz\XO\|aX;uJIF1KDNibXevb4ctKHCxIGHEJIZweiB{ODDkZZl{KG2nYYP1doVlKGGodHXyJIRwe2mwZzDw[ZJqd2R?	M4LTdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{W0NVk6Lz5zOUe1OFE6QTxxYU6=
MV4-11	NEH0XGNCdnSrdIXtc5Ih[XO\|YYm=	MV2xNEBu\y:tZx?=	NGHxRVQzQCCmYYnz	NIrwNWJCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMhgGWwb3fyZYZ1\WRiaX6gZZRpgW2rYzDueYRmKG2xdYPlJIF{e2W\|c3XkJIF{KHS3bX;yJIdzd3e2aDDy[Ydz\XO\|aX;uJIF1KDFyIH3nM4toNCCybzDRSEBnd3JiMkig[IF6eyCvZXHzeZJm\CCjZoTldkBld3OrbnegdIVzcW:m	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd3NEG5PUc,OTl5NUSxPVk9N2F-
MV4-11	NV;jVG5kSW62aYT1cY9zKGG\|c3H5	Mlr5N{Bu\y:tZx?=	MWiyPEBl[Xm\|	M4TtUmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3WOE0yOSClZXzsd{B5\W6xZ4Lh[pRm\CCrbjDheIh6dWmlIH71[IUhdW:3c3WgZZN{\XO\|ZXSgZZMhe3WycILld5Nqd25ib3[geJVud3Jidn;seY1mKGG2IEOgcYcwc2duIIDvJHFFKG[xcjCyPEBl[Xm\|IH3lZZN2emWmIHHmeIVzKGSxc3nu[{Bx\XKrb3S=	NVHIUWZRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3OVQyQTlpPkG5O\|U1OTl7PD;hQi=>
MV4-11	M3m3U2FvfGm2dX3vdkBie3OjeR?=	M2fzRVExKG2pL3vn	NGrGU5AzQCCmYYnz	NWH5epFpSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUXY1NTFzIHPlcIx{KHinbn;ndoFnfGWmIHnuJIF1cHmvaXOgcpVl\SCvb4Xz[UBie3Onc4Pl[EBieyC\|dYDwdoV{e2mxbjDv[kB1fW2xcjD2c4x2dWViYYSgNVAhdWdxa3esJJBwKFGGIH\vdkAzQCCmYYnzJI1m[XO3cnXkJIFnfGW{IHTvd4lv\yCyZYLpc4Q>	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd3NEG5PUc,OTl5NUSxPVk9N2F-
MV4-11	M3znemFvfGm2dX3vdkBie3OjeR?=	MXuxNEBu\y:tZx?=	NY\CeI91OjhiZHH5dy=>	NULO[\|N[SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUXY1NTFzIHPlcIx{KHinbn;ndoFnfGWmIHnuJIF1cHmvaXOgcpVl\SCvb4Xz[UBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJR2dW:{IHfyc5d1cCCjdDCxNEBu\y:tZzygdI8hWURiZn;yJFI5KGSjeYOgcYVie3W{ZXSgZYZ1\XJiM{Kg[IF6eyCyb4P0[I9{\Q>?	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd3NEG5PUc,OTl5NUSxPVk9N2F-
MOLM13	NIrlWItCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			M3i1d2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTV;MUVE{KGOnbHzzJIV5eHKnc4PpcochTkyWMz3JWGQhdXW2YX70MEBIUTVyIE2gNE4xODRizszNMi=>	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{NkmzNUc,OjJ5Mk[5N\|E9N2F-
MV411	MmnwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		MofMOFghcHK\|	NXvuZml{T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVVZ2MUGgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFiWVDDhd5NigSxiR1m1NEA:KDNwM{Gg{txONg>?	NFe2fY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUGwPFA4QSd-MkWxNFgxPzl:L3G+
THP1	NVHpS4JnT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MX:0PEBpenN?	M1Ppe2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHRJWDFiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JHhVXCCjc4PhfUwhT0l3MDC9JFUvPTd2IN88UU4>	M4DEZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUC4NFc6Lz5{NUGwPFA4QTxxYU6=
HL60	NX35PYNGT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M3zuW\|Q5KGi{cx?=	NXnLfHpVT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEx4MDDj[YxteyCjZoTldkA1QCCqcoOgZpkhYFSWIHHzd4F6NCCJSUWwJF0hQC5yMUSg{txONg>?	MnHBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzMEiwO\|koRjJ3MUC4NFc6RC:jPh?=
32D	Mnv1SpVv[3Srb36gZZN{[Xl?		NFrNN\|I4OiCqcoO=	M3nsXGlvcGmkaYTpc44hd2ZiaIXtZY4hTkyWMzDJWGQhdXW2YX70JIV5eHKnc4Pl[EBqdiCvb4Xz[UA{OkRiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRUKGG\|c3H5MEBIUTVyIE2gNE4xODByMTFOwG0v	NEDhO249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC4NVAzOyd-Mk[wPFExOjN:L3G+
MV4-11	MkD0SpVv[3Srb36gZZN{[Xl?		M2TlU\|czKGi{cx?=	MnvaTY5pcWKrdHnvckBw\iCITGSzJGlVTCCqb33vfplod3W\|IH31eIFvfCCrbjDoeY1idiCPVkStNVEh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD6wNFMh\|ryPLh?=	NGXjfXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC4NVAzOyd-Mk[wPFExOjN:L3G+
MOLM-13	MnzLSpVv[3Srb36gZZN{[Xl?		MlnxO\|IhcHK\|	MWLJcohq[mm2aX;uJI9nKE[OVEOgTXRFKGindHXyc5p6\2:3czDteZRidnRiaX6gbJVu[W5iTV;MUU0yOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHMh[XO\|YYmsJGdKPTBiPTCwMlAxPCEQvF2u	NED0NXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC4NVAzOyd-Mk[wPFExOjN:L3G+
32D	MkXJSpVv[3Srb36gZZN{[Xl?		M4\ZPFczKGi{cx?=	NGX5[VhKdmirYnn0bY9vKG:oIHTyeYchemW\|aYP0ZY51KGi3bXHuJGZNXDNiSWTEJGQ5OzW\IH31eIFvfCCneIDy[ZN{\WRiaX6gcY92e2ViM{LEJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMEG2JO69VS5?	Ml\5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOEGwNlMoRjJ4MEixNFI{RC:jPh?=
32D	MoKySpVv[3Srb36gZZN{[Xl?		M4LXd\|czKGi{cx?=	NYLE[49pUW6qaXLpeIlwdiCxZjDkdpVoKHKnc3nzeIFvfCCqdX3hckBHVFR\|IFnUSEBFQDN3VjDteZRidnRiZYjwdoV{e2WmIHnuJI1wfXOnIEOySEBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkCyO{DPxE1w	Ml;3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOEGwNlMoRjJ4MEixNFI{RC:jPh?=
Sf9	NXfPVnpETnWwY4Tpc44h[XO\|YYm=		NVSzcHlzPCCqcoO=	NXzCc4VWUW6qaXLpeIlwdiCxZjD3bYxlKHS7cHWgS3NVNXSjZ3fl[EBHVFR\|IHvpcoF{\SCmb33hbY4hMFl3NkegeI8hWzl7MzmgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiaX7z[YN1KFOoOTDj[YxteyC3c3nu[{BJ\XJ{IIDldJRq\GViYYOgd5Vje3S{YYTlJIFnfGW{IESgbJJ{KGK7IFvpcoF{\S2JbH:gZZN{[XluIFnDOVAhRSByLkC2PUDPxE1w	M3TEZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEixNFI{Lz5{NkC4NVAzOzxxYU6=
32D	NXz6ZlNUTnWwY4Tpc44h[XO\|YYm=		Ml\wO\|IhcHK\|	MYDJcohq[mm2aX;uJI9nKGS{dXegdoV{cXO2YX70JIh2dWGwIF\MWFMhUVSGIFS4N\|VHKG23dHHueEBmgHC{ZYPz[YQhcW5ibX;1d4UhOzKGIHPlcIx{KGG\|c3Xzd4VlKGG\|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JG1VWyCjc4PhfUwhT0l3MDC9JFAvOTVizszNMi=>	NYX0VHpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wPFExOjNpPkK2NFgyODJ\|PD;hQi=>
32D	NHzlb2JHfW6ldHnvckBie3OjeR?=		NX32b3pKPzJiaILz	M2HSS2lvcGmkaYTpc44hd2ZiZIL1[{Bz\XOrc4ThcpQhcHWvYX6gSmxVOyCLVFSgSlY6OUxibYX0ZY51KGW6cILld5Nm\CCrbjDtc5V{\SB\|MlSgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hOC5{MjFOwG0v	MlX2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOEGwNlMoRjJ4MEixNFI{RC:jPh?=
Sf9	MVnGeY5kfGmxbjDhd5NigQ>?		NUTGTGo4OTJyIH3pcpM>	M1fsTWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgS3NVNXSjZ3fl[EBXTUeIUkKgb4lv[XOnIHTvcYFqdiBqVke4PUB1dyCYMUO1OkkhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iaX7z[YN1KFOoOTDj[YxteyC3c3nu[{Bxd2y7R3z1OFpVgXJicHXweIll\SCjczDzeYJ{fHKjdHWgZYZ1\XJiMUKwJI1qdnNiYomgT4lv[XOnLVfsc{Bie3OjeTygTWM2OCB;IECuOFMh\|ryPLh?=	NIf5R2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC4NVAzOyd-Mk[wPFExOjN:L3G+
RS4:11	MlPoSpVv[3Srb36gZZN{[Xl?		MWO3NkBpenN?	NGPuNGdKdmirYnn0bY9vKG:oIIfpcIQhfHmyZTDoc41wgnmpb4XzJGZNXDNiaX6gbJVu[W5iUmO0PlEyKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IEKuNkDPxE1w	NVvKZXNzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wPFExOjNpPkK2NFgyODJ\|PD;hQi=>
MV4-11	Mnr2RY51cXS3bX;yJIF{e2G7	M2XURlExKG2pL3vn	NIT6UFM1QCCmYYnz	MoXLRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTW[0MVEyKGOnbHzzJJhmdm:pcnHmeIVlKGmwIH71[IUhdW:3c3WgZZN{\XO\|ZXSgZZMhfHWvb4KgdoVoemW\|c3nvckBifCBzMDDt[{9s\yxicH:gdYQh[WSvaX7pd5RmemWmIH;uJIRigSBzIITvJFUhdWWjc4Xy[YQh\HW{aX7nJFQ5KGSjeYOgdI9{fCCuYYP0JIRwe2V?	Mn7yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOEGwNlMoRjJ4MEixNFI{RC:jPh?=
MV4-11	MYnBcpRqfHWvb4KgZZN{[Xl?	MWixNEBu\y:tZx?=	M4nQNFQ5KGSjeYO=	NFzpNXRCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMhgGWwb3fyZYZ1\WRiaX6gcpVl\SCvb4Xz[UBie3Onc4Pl[EBieyC2dX3vdkBz\We{ZYPzbY9vKGG2IEGwJI1oN2upLDDwc{By\CCjZH3pcol{fGW{ZXSgc44h\GG7IEigeI8hOTJibXXhd5Vz\WRiZIXybY5oKDR6IHThfZMheG:\|dDDsZZN1KGSxc3W=	NVL6[nhqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wPFExOjNpPkK2NFgyODJ\|PD;hQi=>
MV4-11	NInlV\|REgXSxdH;4bYNqfHliYYPzZZk>		M3:wNFczKGi{cx?=	NEW1[\|VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOXjRvMUGgZ4VtdHNiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMEC2PEDPxE1w	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF2MkOxO{c,OjZzNEKzNVc9N2F-
Sf21	MmLqSpVv[3Srb36gZZN{[Xl?		NWL2fWRsOTVibXnudy=>	NYXiS4MyUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDGUHQ{KGW6cILld5Nm\CCrbjDpcpNm[3RiU3[yNUBk\WyuczDwdoVqdmO3YnH0[YQh\m:{IEG1JI1qdnNiZn;scI94\WRiYomgdI9tgSiJbIW6WJlzMSC\|dXLzeJJifGViYXTkbZRqd25iZn;yJFMxKG2rboOgbY4heHKnc3XuZ4Uhd2ZiW3fhcY1iNTN{UG3BWHAh[nliVGKtSnJGXCCjc4PhfUwhUUN3MDC9JFAvODJ4MEig{txONg>?	NES5V\|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G4O\|g3OCd-MkexPFc5PjB:L3G+
MV4-11	M3PpTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MYC0PEBpenN?	MmXjS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUXY1NTFzIHPlcIx{KGW6cILld5NqdmdiRlzUN{1KXERiYX\0[ZIhPDhiaILzJIJ6KFiWVDDhd5NigSxiR1m1NEA:KDFwMUCzJO69VS5?	NE\mWHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G4O\|g3OCd-MkexPFc5PjB:L3G+
HL60	NHfYUG9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MUK0PEBpenN?	MVzHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIUFYxKGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKE[OVD2zJIFnfGW{IES4JIhzeyCkeTDYWHQh[XO\|YYmsJGdKPTBiPTCxMlQ5QCEQvF2u	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF6N{i2NEc,OjdzOEe4OlA9N2F-
THP1	MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MYq0PEBpenN?	MVvHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDUTHAyKGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKE[OVD2zJIFnfGW{IES4JIhzeyCkeTDYWHQh[XO\|YYmsJGdKPTBiPTCyMlEzPSEQvF2u	MkXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzOEe4OlAoRjJ5MUi3PFYxRC:jPh?=
K562	MlnlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NUHOSm9QPDhiaILz	NXP0SJJsT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhYFSWIHHzd4F6NCCJSUWwJF0hOi54M{ig{txONg>?	NWCyTFdyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexPFc5PjBpPkK3NVg4QDZyPD;hQi=>
Sf21	M1XtSWZ2dmO2aX;uJIF{e2G7		MoPzNVAhdWmwcx?=	MoHDTY5pcWKrdHnvckBw\iCQLYTldo1qdmGuIFfTWE11[WepZXSgdoVkd22kaX7hcpQhcHWvYX6ge4lt\C22eYDlJGZNXDNiKEW2OEB1dyCnbnSgdoV{cWS3ZYOpJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDz[lIyKGOnbHzzJJV{cW6pIFHicJRq\GViYYOgd5Vje3S{YYTlJIlvKHC{ZYPlcoNmKG:oIGvnZY1u[TN\|UG3BWHAh[W[2ZYKgNVAhdWmwczDifUB{[2mwdHnscIF1cW:wIHPveY51cW6pIH3leIhw\CxiSVO1NEA:KDBwMEK1OUDPxE1w	M3;NdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MESzO\|k1Lz5{OEC0N\|c6PDxxYU6=
Sf21	NX:wcJVOTnWwY4Tpc44h[XO\|YYm=		NXHHbnJqOTBibXnudy=>	M{PYOGlvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDHV3QufGGpZ3XkJJJm[2:vYnnuZY51KGi3bXHuJJdqdGRvdInw[UBHVFR\|IDi1OlQhfG9iZX7kJJJme2mmdXXzLUBFQDN3WTDteZRidnRiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKHOoMkGgZ4VtdHNidYPpcochSWKudHnk[UBieyC\|dXLzeJJifGViaX6gdJJme2WwY3Wgc4YhY2ejbX3hN\|NRZUGWUDDh[pRmeiBzMDDtbY5{KGK7IIPjbY51cWyuYYTpc44h[2:3boTpcochdWW2aH;kMEBKSzVyIE2gNE4zOzV3IN88UU4>	NIfwPYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC0N\|c6PCd-MkiwOFM4QTR:L3G+
MV4-11	M3zkbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			Mne5S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUXY1NTFzIHPlcIx{KGijcnLvdolv\yCITGSzMWlVTCCvdYThcpQh[nliWGTUJIF{e2G7LDDHTVUxKD1iMT6xNFMh\|ryPLh?=	MknBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyNEO3PVQoRjJ6MESzO\|k1RC:jPh?=
THP1	M17CSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NUG2PHdXT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hXEiSMTDj[YxteyCqYYLic5Jqdmdid3ns[E11gXCnIF\MWFMh[nliWGTUJIF{e2G7LDDHTVUxKD1iMj6xNlUh\|ryPLh?=	M4LnTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MESzO\|k1Lz5{OEC0N\|c6PDxxYU6=
BAF3	MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MoTSO\|IhcHK\|	NGL6d4lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBSlMh[2WubIOgbIFz[m:{aX7nJGZNXDNvSWTEMWQ5OzWJIH31eIF1cW:wIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIF{e2G7LDDHTVUxKD1iMD6wNFA{KM7:TT6=	NIr6T3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkzOyd-Mki5OVY6OjN:L3G+
BAF3	NXzuXpB7SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MmHtO\|IhcHK\|	NFTKPG1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBSlMh[2WubIOgbIFz[m:{aX7nJGZNXDNvSWTEMWQ5OzWDIH31eIF1cW:wIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIF{e2G7LDDHTVUxKD1iMD6wNFA{KM7:TT6=	NIXRNJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkzOyd-Mki5OVY6OjN:L3G+
BAF3	NX;CR2VkSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MU[3NkBpenN?	NVLGR\|ZqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRWY{KGOnbHzzJIhiemKxcnnu[{BHVFR\|LVS4N\|VJKG23dHH0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIHHzd4F6NCCJSUWwJF0hOC5yMECzJO69VS5?	NVjHOJpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OjNpPkK4PVU3QTJ\|PD;hQi=>
MOLM13	MorVRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MVy3NkBpenN?	MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2RTF2xN{Bk\WyuczDoZZJjd3KrbnegSmxVOy2LVFSgcZV1[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8h[XO\|YYmsJGdKPTBiPTCwMlAxODNizszNMi=>	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
BAF3	MY\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MXq3NkBpenN?	M36yNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlHGN{Bk\WyuczDlfJBz\XO\|aX7nJHRGVC2odYPl[EBHVFR\|IHvpcoF{\SCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDhd5NigSxiR1m1NEA:KDBwMECwN{DPxE1w	M4f5NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUW2PVI{Lz5{OEm1OlkzOzxxYU6=
BAF3	NHzPNlVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NXXxSIN6PzJiaILz	MlvrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQV[zJINmdGy\|IHjhdoJwemmwZzDGUHQ{NUmWRD3EPFM2ViCvdYTheIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDhd5NigSxiR1m1NEA:KDBwMECwN{DPxE1w	NFvkXGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkzOyd-Mki5OVY6OjN:L3G+
MOLM14	NIT3ZodCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NE[0NVU4OiCqcoO=	MnPrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPT1zNNVQh[2WubIOgbIFz[m:{aX7nJGZNXDNvSWTEJI12fGG2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGG\|c3H5MEBIUTVyIE2gNE4xODB\|IN88UU4>	NVu2XVFwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OjNpPkK4PVU3QTJ\|PD;hQi=>
BAF3	NV7P[3RKSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NWHLOXh{PzJiaILz	NWfob5hQSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRWY{KGOnbHzzJIhiemKxcnnu[{BHVFR\|LVnUSEBufXSjdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCjc4PhfUwhT0l3MDC9JFAvODByMzFOwG0v	M1;m[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUW2PVI{Lz5{OEm1OlkzOzxxYU6=
MV4-11	NUXKd3pZSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NUXUWJNxPzJiaILz	M1SwNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTW[0MVEyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGG\|c3H5MEBIUTVyIE2gNE4xODB\|IN88UU4>	NI\Ge4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkzOyd-Mki5OVY6OjN:L3G+
BAF3	NH3uSopCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MY[3NkBpenN?	NXvHW5RTSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBVTUxvZoXz[YQhWESJRmLhcJBp[S22cnHud4Zwem2nZDDtc5V{\SCEQV[zJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIF{e2G7LDDHTVUxKD1iMD6wNFA{KM7:TT6=	NHvJR2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkzOyd-Mki5OVY6OjN:L3G+
BAF3	NIH6XYpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NYfrV5I6PzJiaILz	MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDRkOgZ4VtdHNiaHHyZo9zcW6pIF\MWFMuTDh\|NWmgcZV1[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8h[XO\|YYmsJGdKPTBiPTCwMlAxOiEQvF2u	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
BAF3	MUfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MX63NkBpenN?	MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IGTFUE1nfXOnZDDQSGdHWmKndHGteJJidnOob4Lt[YQhdW:3c3WgRmFHOyClZXzsd{Bi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCjc4PhfUwhT0l3MDC9JFAvODB2NDFOwG0v	NYTxcJRiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OjNpPkK4PVU3QTJ\|PD;hQi=>
BAF3	M4nFSGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NV[5XGdMPzJiaILz	NYHlenBESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRWY{KGOnbHzzJIhiemKxcnnu[{BHVFR\|LVS4N\|VXKG23dHH0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIHHzd4F6NCCJSUWwJF0hOC5yMUGg{txONg>?	NF;Temo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkzOyd-Mki5OVY6OjN:L3G+
BAF3	NF\HO5ZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MXe3NkBpenN?	MmTvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQV[zJINmdGy\|IHjhdoJwemmwZzDGUHQ{NUmWRD3EPFM2\GWuIH31eIF1cW:wIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIF{e2G7LDDHTVUxKD1iMD6wNVIh\|ryPLh?=	NXOwepZmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OjNpPkK4PVU3QTJ\|PD;hQi=>
Sf9	NIDBcpBHfW6ldHnvckBie3OjeR?=		MX[xJIhz	NI\DW4xKdmirYnn0bY9vKG:oIHj1cYFvKE2YND2xNUBk\Wyucz3k[ZJqfmWmIFjpd{11[WepZXSgSmxVOyCLVFSgcZV1[W62IDi1OlQhfG9iOUmzJJJme2mmdXXzLUBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgd4Y6KGOnbHzzJJV{cW6pIIDvcJkhMDR8MTDHcJUtKFS7cjmgZZMhe3Wkc4TyZZRmKGGodHXyJFEhcHJiYomgRWRRNUeubzDrbY5ie2ViYYPzZZktKEmFNUCgQUAxNjBzNkig{txONg>?	MnHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NU[5NlMoRjJ6OUW2PVI{RC:jPh?=
BAF3	MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MkXoO\|IhcHK\|	MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IGTFUE1nfXOnZDDjT2lVNXS{YX7z[o9zdWWmIH3veZNmKEKDRkOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gZZN{[XluIFfJOVAhRSByLkCxO{DPxE1w	MnOxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NU[5NlMoRjJ6OUW2PVI{RC:jPh?=
BAF3	NGTQ[YhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M1XuelczKGi{cx?=	MofrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDUSWwu\nW\|ZXSgR3NHOVJvdILhcpNnd3KvZXSgcY92e2ViQlHGN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{Bie3OjeTygS2k2OCB;IECuNFI1KM7:TT6=	NVjqdnRERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OjNpPkK4PVU3QTJ\|PD;hQi=>
BAF3	MWXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NXzySmtqPzJiaILz	NIHDbnVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBSlMh[2WubIOgbIFz[m:{aX7nJGZNXDNvSWTEMWQ5OzW\IH31eIF1cW:wIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIF{e2G7LDDHTVUxKD1iMD6wNlgh\|ryPLh?=	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
Sf9	NXrISY0xTnWwY4Tpc44h[XO\|YYm=		MlTkNUBpeg>?	NX[xemFDUW6qaXLpeIlwdiCxZjDoeY1idiCKTE[wJINmdGy\|LXTldol3\WRiSHnzMZRi\2enZDDGUHQ{KCh3NkSgeI8hQTl\|IILld4llfWW\|KTDlfJBz\XO\|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRic3[5JINmdGy\|IIXzbY5oKHCxbImgLFQ7OSCJbIWsJHR6eiliYYOgd5Vje3S{YYTlJIFnfGW{IEGgbJIh[nliQVTQMWdtdyCtaX7hd4Uh[XO\|YYmsJGlEPTBiPTCwMlA{ODRizszNMi=>	NXuxZ3I5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OjNpPkK4PVU3QTJ\|PD;hQi=>
BAF3	MkTzRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		Mn\JO\|IhcHK\|	MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDRkOgZ4VtdHNiaHHyZo9zcW6pIF\MWFMuUVSGLVS4N\|VKKG23dHH0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIHHzd4F6NCCJSUWwJF0hOC5yNU[g{txONg>?	NXLhfpl1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OjNpPkK4PVU3QTJ\|PD;hQi=>
BAF3	M3\MZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MVi3NkBpenN?	M3vuR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgWGVNNW[3c3XkJGRFWjJvdILhcpNnd3KvZXSgcY92e2ViQlHGN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{Bie3OjeTygS2k2OCB;IECuNVEh\|ryPLh?=	M{mz[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUW2PVI{Lz5{OEm1OlkzOzxxYU6=
BAF3	NF;zUmpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M1P6eVczKGi{cx?=	NWrJd45zSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBVTUxvZoXz[YQhTESUMT30doFve2[xcn3l[EBud3W\|ZTDCRWY{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGG\|c3H5MEBIUTVyIE2gNE4yOiEQvF2u	M3LEdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUW2PVI{Lz5{OEm1OlkzOzxxYU6=
CMK	NWHhRmF2SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NG\YSnA4OiCqcoO=	M{PNe2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ13LJINmdGy\|IHX4dJJme3OrbnegSmxVOyCtaX7hd4Uh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9iYYPzZZktKEeLNUCgQUAxNjF{IN88UU4>	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
BAF3	MmPpRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MXO3NkBpenN?	Mo[1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDUSWwu\nW\|ZXSgVmVVNXS{YX7z[o9zdWWmIH3veZNmKEKDRkOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gZZN{[XluIFfJOVAhRSByLkGzJO69VS5?	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
HL60	NFjsR4VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NUT5flQxPzJiaILz	M{XSPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczDlfJBz\XO\|aX7nJGZNXDNia3nuZZNmKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIHHzd4F6NCCJSUWwJF0hOC5zMzFOwG0v	MmHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NU[5NlMoRjJ6OUW2PVI{RC:jPh?=
BAF3	NIfMeGRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NVvQ[pp5PzJiaILz	MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IGTFUE1nfXOnZDDGUHQ1NXS{YX7z[o9zdWWmIH3veZNmKEKDRkOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gZZN{[XluIFfJOVAhRSByLkK3JO69VS5?	M{TIVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUW2PVI{Lz5{OEm1OlkzOzxxYU6=
BAF3	M3;EOWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NWH3bIlWPzJiaILz	M{\admFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlHGN{Bk\WyuczDoZZJjd3KrbnegSmxVOy2NNk[zVUBufXSjdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCjc4PhfUwhT0l3MDC9JFAvOzdizszNMi=>	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
BAF3	NYHBcJk{SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NVW3Onc2PzJiaILz	MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IGTFUE1nfXOnZDDMR2sufHKjboPmc5Ju\WRibX;1d4UhSkGIMzDj[YxteyCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDhd5NigSxiR1m1NEA:KDBwNDFOwG0v	NIHmd4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkzOyd-Mki5OVY6OjN:L3G+
U937	Mn3ZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NHXGRpo4OiCqcoO=	MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV7M{egZ4VtdHNiZYjwdoV{e2mwZzDGUHQ{KGurbnHz[UBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCjc4PhfUwhT0l3MDC9JFEvOiEQvF2u	NXf0O\|F3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OjNpPkK4PVU3QTJ\|PD;hQi=>
SKM1	NEDJeXlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NHLUeFk4OiCqcoO=	NWSxNoZYSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTT20yKGOnbHzzJIV5eHKnc4PpcochTkyWMzDrbY5ie2ViYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gZZN{[XluIFfJOVAhRSBzLkOg{txONg>?	NV\Qb4pwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OjNpPkK4PVU3QTJ\|PD;hQi=>
NB4	NXrPUFdZSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M4LofVczKGi{cx?=	MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6ENDDj[YxteyCneIDy[ZN{cW6pIF\MWFMhc2mwYYPlJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGG\|c3H5MEBIUTVyIE2gO{4{KM7:TT6=	NGi3NHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkzOyd-Mki5OVY6OjN:L3G+
MOLM13	NWTKclJxS2WubDDjfYNt\SCjc4PhfS=>	MkDiNVAxKG6P	NHHZUpEyOiCqcoO=	M{i5RWNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJG1QVE1zMzDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{CvS\|EheGijc3WgZZQhOTByIH7NJIFnfGW{IEGyJIhzeyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pIHLhd4VlNU[DQ2OgZY5idHm\|aYO=	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
MOLM14	NUC1XJBxS2WubDDjfYNt\SCjc4PhfS=>	NXXIfm54OTByIH7N	NHrLdYcyOiCqcoO=	NVXIco1bS2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hVU:OTUG0JINmdGy\|IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDHNE9IOSCyaHHz[UBifCBzMECgcm0h[W[2ZYKgNVIhcHK\|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnegZoF{\WRvRlHDV{BidmGueYPpdy=>	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
MOLM13	MW\BdI9xfG:\|aYOgZZN{[Xl?	NVrpUYNtOTByIH7N	MWOxNkBpenN?	NIXjN\|lKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIF3PUG0yOyClZXzsd{Bie3Onc4Pl[EBieyClbHXheoFo\SCxZjDQRXJRKGG2IEGwNEBvVSCjZoTldkAyOiCqcoOgZpkhcW2vdX7vZoxwfHSrbnegcYV1cG:m	NHuyZYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkzOyd-Mki5OVY6OjN:L3G+
MV4-11	NVXtTWJtSXCxcITvd4l{KGG\|c3H5	NVnlVmhUOTByIH7N	M3zadFQ5KGi{cx?=	NXf6TlFMUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDNWlQuOTFiY3XscJMh[XO\|ZYPz[YQh[XNiY3zlZZZi\2Vib3[gVGFTWCCjdDCxNFAhdk1iYX\0[ZIhPDhiaILzJIJ6KGmvbYXuc4Jtd3S2aX7nJI1mfGixZB?=	M2jTcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUW2PVI{Lz5{OEm1OlkzOzxxYU6=
MOLM13	MYLBdI9xfG:\|aYOgZZN{[Xl?	MWKxNFAhdk1?	MmnVNVIhcHK\|	NIi2fVVKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIF3PUG0yOyClZXzsd{Bie3Onc4Pl[EBieyClbHXheoFo\SCxZjDjZZNx[XOnLUOgZZQhOTByIH7NJIFnfGW{IEGyJIhzeyCkeTDpcY12dm:kbH;0eIlv\yCvZYToc4Q>	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
MOLM14	M2HMbmFxd3C2b4Ppd{Bie3OjeR?=	MYGxNFAhdk1?	MmjlNlQhcHK\|	MUfJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2RTF2xOEBk\WyuczDhd5Nme3OnZDDhd{BkdGWjdnHn[UBw\iCSQWLQJIF1KDFyMDDuUUBi\nSncjCyOEBpenNiYomgbY1ufW6xYnzveJRqdmdibXX0bI9l	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
MOLM14	NFfQOG9CeG:ydH;zbZMh[XO\|YYm=	MVWxNFAhdk1?	M4nOfFI1KGi{cx?=	MlfUTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCPT1zNNVQh[2WubIOgZZN{\XO\|ZXSgZZMh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1\|IHH0JFExOCCwTTDh[pRmeiB{NDDodpMh[nliaX3teY5w[myxdITpcochdWW2aH;k	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
MV4-11	M2XveWFxd3C2b4Ppd{Bie3OjeR?=	M1XadVExOCCwTR?=	MlviOFghcHK\|	NWXpdHhrUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDNWlQuOTFiY3XscJMh[XO\|ZYPz[YQh[XNiY3zlZZZi\2Vib3[gZ4F{eGG\|ZT2zJIF1KDFyMDDuUUBi\nSncjC0PEBpenNiYomgbY1ufW6xYnzveJRqdmdibXX0bI9l	NX\FXIhGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OjNpPkK4PVU3QTJ\|PD;hQi=>
MV4-11	MX\D[YxtKGO7Y3zlJIF{e2G7	NHrFXVQyODBibl2=	M17FVlEzKGi{cx?=	NEfFdYVE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBOXjRvMUGgZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IFewM2cyKHCqYYPlJIF1KDFyMDDuUUBi\nSncjCxNkBpenNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZzDiZZNm\C2IQVPTJIFv[Wy7c3nz	MnvKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NU[5NlMoRjJ6OUW2PVI{RC:jPh?=
Saos-2	NYrLdZZZeUiWUzDhd5NigQ>?			NXXuRm5FeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPhc5MuOiClZXzsdy=>	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
MG 63 (6-TG R)	MnnkdWhVWyCjc4PhfS=>			M{f0[5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCPRzC2N{ApPi2WRzDSLUBk\Wyucx?=	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
BT-12	MmLldWhVWyCjc4PhfS=>			MoPNdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgRnQuOTJiY3XscJM>	Mk[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
LAN-5	MnHRdWhVWyCjc4PhfS=>			M3nZdpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGxCVi13IHPlcIx{	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
DAOY	M2LzVJFJXFNiYYPzZZk>			MV;xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDERW9[KGOnbHzz	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SK-N-SH	M3;JbpFJXFNiYYPzZZk>			NXrEeWQyeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW0tvTj3TTEBk\Wyucx?=	NEXRc5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
A673	NFq5d3ZyUFSVIHHzd4F6			NXzSPHExeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhSTZ5MzDj[Yxteyl?	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
BT-37	NXnKc3NYeUiWUzDhd5NigQ>?			NVX5VIlmeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHN?	M3HUUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
U-2 OS	NXyyOZN5eUiWUzDhd5NigQ>?			M4Oxe5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHUuOiCRUzDj[Yxtew>?	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
OHS-50	Mlz5dWhVWyCjc4PhfS=>			M{TOXZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG9JWy13MDDj[Yxtew>?	NYL4copzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
Rh41	NW[zRVE{eUiWUzDhd5NigQ>?			NXrjc2ZzeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhWmh2MTDj[Yxtew>?	M3fOeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SJ-GBM2	M3ixV5FJXFNiYYPzZZk>			MU\xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0pvR1LNNkBk\Wyucx?=	NVHObopxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-MC	MXfxTHRUKGG\|c3H5			NE\wWG5yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=>	NVfqVIJ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB-EBc1	NYf4bVI4eUiWUzDhd5NigQ>?			Mom4dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKE6ELVXCZ\|Eh[2WubIO=	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
NB1643	NGLHZZJyUFSVIHHzd4F6			NYnMVFNjeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhVkJzNkSzJINmdGy\|	NYTjSlQyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-MC	Ml;sdWhVWyCjc4PhfS=>			NFmzPY5yUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBUUy2QLV3DJINmdGy\|	MmjGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
SJ-GBM2	Mn32dWhVWyCjc4PhfS=>			NHq2TYxyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBUUi2JQl2yJINmdGy\|	Mlq3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
TC32	MoDidWhVWyCjc4PhfS=>			MYnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDUR\|MzKGOnbHzz	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
MOLM13	NV7oSpIzT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MUi3NkBpenN?	M{DMZ2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1QVE1zMzDj[YxteyCjZoTldkA4OiCqcoOgZpkh[2GuY3XpckBCVSCmeXWtZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7LDDHTVUxKD1iMD6wNFIh\|ryPLh?=	M1zNUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkeyNFQ6Lz5{OU[3NlA1QTxxYU6=
MV4-11	MkLlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NIrhT4w4OiCqcoO=	MYfHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNWlQuOTFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JINidGOnaX6gRW0h\HmnLXLhd4VlKG[udX;y[ZNk\W6lZTDhd5NigSxiR1m1NEA:KDBwMECzJO69VS5?	MkfPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{KwOFkoRjJ7NkeyNFQ6RC:jPh?=
BA/F3	Mon3SpVv[3Srb36gZZN{[Xl?		MnTOO\|IhcHK\|	NHnGZ5lKdmirYnn0bY9vKG:oIF\MWFMhUVSGIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBk[WylZXnuJGFOKGS7ZT3iZZNm\CCobIXvdoV{[2WwY3WgZZN{[XluIFfJOVAhRSByLkCwO{DPxE1w	NILUVJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[3NlA1QSd-Mkm2O\|IxPDl:L3G+
Sf9	MlHESpVv[3Srb36gZZN{[Xl?			MVXJcohq[mm2aX;uJI9nKE5vdHXycYlv[WxiR2PUM2hqezZvZoXz[YQhemWlb33ibY5idnRiaIXtZY4hTkyWMzCoVlU4OSC2bzDTPVk{KHKnc3nkeYV{MSCLVFSgcZV1[W62IHX4dJJme3OnZDDpckBU\jliaX7z[YN1KGOnbHzzJJV{cW6pIIDvcJkhMEGuYTzHcJUtVHm\|LGT5dkkhPjp{OkW6NUBpgWS{b3Lyc41q\GViYYOgd5Vje3S{YYTlJIlvKHC{ZYPlcoNmKG:oIGvnZY1u[S1\|M2DdRXRRNCCLQ{WwJF0hOC5yMTFOwG0v	NXnMNplKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O\|IxPDlpPkK5OlczODR7PD;hQi=>
Sf9	M3XjSmZ2dmO2aX;uJIF{e2G7			MXrJcohq[mm2aX;uJI9nKE5vdHXycYlv[WxiR2PUM2hqezZvZoXz[YQhemWlb33ibY5idnRid3ns[EB1gXCnIHj1cYFvKE[OVEOgLHI2PzFidH:gV\|k6OyC{ZYPp[JVmeyliZYjwdoV{e2WmIHnuJHNnQSCrboPlZ5Qh[2WubIOgeZNqdmdicH;sfUApSWyjLFfseUxNgXNuVInyLUA3QjJ8NUqxJIh6\HKxYoLvcYll\SCjczDzeYJ{fHKjdHWgbY4heHKnc3XuZ4Uhd2ZiW3fhcY1iNTN\|UG3BWHAtKEmFNUCgQUAxNjB\|NjFOwG0v	NH\1NpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[3NlA1QSd-Mkm2O\|IxPDl:L3G+
Kasumi-1	NWLYb5Z1T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MkjUO\|IhcHK\|	NGX2SZdIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBM[XO3bXmtNUBk\WyuczDh[pRmeiB5MjDodpMh[nliY3HsZ4VqdiCDTTDkfYUu[mG\|ZXSg[ox2d3Knc3PlcoNmKGG\|c3H5MEBIUTVyIE2gNE4xPjRizszNMi=>	M1fvelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkeyNFQ6Lz5{OU[3NlA1QTxxYU6=
Sf9	NX3TTphoTnWwY4Tpc44h[XO\|YYm=			NHzkXVlKdmirYnn0bY9vKG:oIF6teIVzdWmwYXygS3NVN0irc{[t[pV{\WRicnXjc41jcW6jboSgbJVu[W5iRlzUN{ApWjV5MTD0c{BUQTl\|IILld4llfWW\|KTDEPFM2YSCvdYThcpQh\XiycnXzd4VlKGmwIGPmPUBqdnOnY4SgZ4VtdHNidYPpcocheG:ueTCoRYxiNEeudTzMfZMtXHm{KTC2PlI7PTpzIHj5[JJw[nKxbXnk[UBieyC\|dXLzeJJifGViaX6gdJJme2WwY3Wgc4YhY2ejbX3hMVM{WF2DVGCsJGlEPTBiPTCwMlE{PiEQvF2u	NFTZZlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[3NlA1QSd-Mkm2O\|IxPDl:L3G+
BA/F3	NFHFW\|FIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NI\YZWU4OiCqcoO=	MYfHdo94fGhiaX7obYJqfGmxbjDv[kBud3W\|ZTDCRU9HOyClZXzsd{Bi\nSncjC3NkBpenNiYomgZ4Ft[2WrbjDBUUBlgWVvYnHz[YQh\my3b4Lld4NmdmOnIHHzd4F6NCCJSUWwJF0hOS52NUKg{txONg>?	M2fFNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkeyNFQ6Lz5{OU[3NlA1QTxxYU6=
MV4-11	MoHPSpVv[3Srb36gZZN{[Xl?	MX[wMlAyKHSxIEGwNEBvVQ>?	M1rXeFEhcHJ?	NGjDbHhKdmirYnn0bY9vKG:oIF\MWFMhUVSGIH31eIFvfCCrbjDoeY1idiCPVkStNVEh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iQVvUJJBpd3OyaH;yfYxifGmxbjDheEBUPDd\|IHH0JFAvODFidH:gNVAxKG6PIHHmeIVzKDFiaIKgZpkhcW2vdX7vZoxwfCCjbnHsfZNqew>?	MnjsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{KwOFkoRjJ7NkeyNFQ6RC:jPh?=
MV4-11	M3XPeGZ2dmO2aX;uJIF{e2G7	M2\iclAvODFidH:gNVAxKG6P	NGnQZo0yKGi{	MlH2TY5pcWKrdHnvckBw\iCITGSzJGlVTCCvdYThcpQhcW5iaIXtZY4hVVZ2LUGxJINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKE2HS{GvNkBxcG:\|cHjvdplt[XSrb36gZZQhWzJzNz:yNlEh[XRiMD6wNUB1dyBzMECgcm0h[W[2ZYKgNUBpeiCkeTDpcY12dm:kbH;0JIFv[Wy7c3nz	NUCxeoozRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2O\|IxPDlpPkK5OlczODR7PD;hQi=>
MV4-11	MXPGeY5kfGmxbjDhd5NigQ>?	MWWxJI5O	MXqxJIhz	MmjtTY5pcWKrdHnvckBw\iCITGSzJGlVTCCvdYThcpQh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDZOVg6NzV7MTDpckBpfW2jbjDNWlQuOTFiY3XscJMh[XRiMTDuUUBi\nSncjCxJIhzKGK7IHntcZVvd2Kub4SgZY5idHm\|aYO=	M2PpblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkeyNFQ6Lz5{OU[3NlA1QTxxYU6=
MV4-11	NF6zcGxHfW6ldHnvckBie3OjeR?=	NF7lOHMyKG6P	NEPj[nUyKGi{	Mo\ITY5pcWKrdHnvckBw\iCITGSzJGlVTCCvdYThcpQh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDZPFQzKGmwIHj1cYFvKE2YND2xNUBk\WyuczDheEAyKG6PIHHmeIVzKDFiaIKgZpkhcW2vdX7vZoxwfCCjbnHsfZNqew>?	M3\qNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkeyNFQ6Lz5{OU[3NlA1QTxxYU6=
MV4-11	MUHGeY5kfGmxbjDhd5NigQ>?	MofBNE4xOSC2bzCxNFAhdk1?	MoTKNUBpeg>?	NXTjbZFJUW6qaXLpeIlwdiCxZjDGUHQ{KEmWRDDteZRidnRiaX6gbJVu[W5iTW[0MVEyKGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIGPURXQ2KHCqb4PwbI9zgWyjdHnvckBifCC\Nkm0JIF1KDBwMEGgeI8hOTByIH7NJIFnfGW{IEGgbJIh[nliaX3teY5w[myxdDDhcoFtgXOrcx?=	M16wSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkeyNFQ6Lz5{OU[3NlA1QTxxYU6=
MV4-11	M{H6S2Z2dmO2aX;uJIF{e2G7	MVGwMlAyKHSxIEGwNEBvVQ>?	NFntVpAyKGi{	MlvtTY5pcWKrdHnvckBw\iCITGSzJGlVTCCvdYThcpQhcW5iaIXtZY4hVVZ2LUGxJINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKEWUS{GvNkBxcG:\|cHjvdplt[XSrb36gZZQhXDJyMj;ZNlA1KGG2IECuNFEhfG9iMUCwJI5OKGGodHXyJFEhcHJiYomgbY1ufW6xYnzveEBidmGueYPpdy=>	MoDjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4N{KwOFkoRjJ7NkeyNFQ6RC:jPh?=
MV4-11	M3HSTWZ2dmO2aX;uJIF{e2G7	MWWxNEBu\y:tZx?=	Mk\mNlQhcHK\|	NEfxRVlKdiC4aY\vJIlvcGmkaYTpc44hd2ZiRlzUN{BKXERibYX0ZY51KGmwIHj1cYFvKE2YND2xNUBk\WyuczD4[Y5w\3KjZoTl[EBqdiCjdHj5cYlkKG63L371JI1wfXOnIHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKFOWQWS1JJBpd3OyaH;yfYxifGmxbjDheEB[Pjl2IHH0JFExKG2pL3vnMEBqeCCjZoTldkAzPCCqcoOgZpkhcW2vdX7vZoxwfCCvZYToc4QhemWuYYTpeoUhfG9iY3;ueJJwdA>?	NH;SblQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[3NlA1QSd-Mkm2O\|IxPDl:L3G+
MV4-11	NY\Sc4U5TnWwY4Tpc44h[XO\|YYm=	NW\3N49wOC5zIIXN	M{fpcFQhcHK\|	NGrORllKdmirYnn0bY9vKG:oIF\MWFMhcW5iaIXtZY4hVVZ2LUGxJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCDS2SgdIhwe3Cqb4L5cIF1cW:wIHH0JHNmejR5MzDy[ZNq\HWnIHH0JFAvOSC3TTDh[pRmeiB2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm\|aYO=	NGe5XI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUi5OFk1PCd-Mkm4PVQ6PDR:L3G+
MV4-11	NF\Ue2xHfW6ldHnvckBie3OjeR?=	NE\ScW8xNjFidV2=	MVG0JIhzew>?	NFntWYhKdmirYnn0bY9vKG:oIF\MWFMhcW5iaIXtZY4hVVZ2LUGxJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCVVFHUOUBxcG:\|cHjvdplt[XSrb36gZZQhXHm{Nkm0JJJme2mmdXWgZZQhOC5zIIXNJIFnfGW{IESgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=>	NIfXeZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUi5OFk1PCd-Mkm4PVQ6PDR:L3G+
MV4-11	NFzCRnFHfW6ldHnvckBie3OjeR?=	M1jsO\|AvOSC3TR?=	M2nZcFQhcHK\|	Mlm4TY5pcWKrdHnvckBw\iCITGSzJIlvKGi3bXHuJG1XPC1zMTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hTVKNMT:yJJBpd3OyaH;yfYxifGmxbjDheEBVcHJ{MEKvWJlzOjB2IILld4llfWW\|IHH0JFAvOSC3TTDh[pRmeiB2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm\|aYO=	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTh7NEm0OEc,Ojl6OUS5OFQ9N2F-
MV4-11	NVvneWpWTnWwY4Tpc44h[XO\|YYm=	MnHINE4yKHWP	MWC0JIhzew>?	M4Dj[WlvcGmkaYTpc44hd2ZiRlzUN{BxcG:\|cHjvdplt[XSrb36gZZQhXHm{NUi5M\|U6OSC{ZYPp[JVmeyCrbjDoeY1idiCPVkStNVEh[2WubIOgZZQhOC5zIIXNJIFnfGW{IESgbJJ{KGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=>	NVHlOXJERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4PVQ6PDRpPkK5PFk1QTR2PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-STAT5 / STAT5 / β-catenin / p-AKT / AKT / p-ERK / ERK / p-S6 / S6; PubMed: 28625976 Cancer Res Western blot analysis of AC220 treated MV4-11 cells. Cells were starved for overnight and treated with AC220 at indicated concentrations. Cells were harvested after 2 hours treatment and lysed. Then western blots analysis was performed. The quantification of bands are shown below the gel. phospho-FLT3 / FLT3; PubMed: 22875611 Haematologica (B) The same cells were also harvested for Western blot analysis after treatment for 90 min with different concentrations of AC220. The phosphorylation of the different FLT3 proteins was determined using a phospho-FLT3 antibody.	28625976 22875611
Immunofluorescence	WGA / FLT3 ; PubMed: 28895560 Leukemia Immunofluorescence staining of FLT3-WT, FLT3 mutants or empty vector with or without AC220 treatment in transiently transfected U2OS cells. WGA (wheat germ agglutinin). Scale bar: 25 μm.	28895560
Growth inhibition assay	Cell viability; PubMed: 23967177 PLoS One K562/ABCB1 and K562/ABCG2 cells exhibit collateral sensitivity toquizartinib. K562, K562/ABCB1 and K562/ABCG2 cells were plated in the presence of quizartinib in increasing concentrations for 96 hours and viable cells were measured using the WST-1 assay.	23967177

体内研究

AC220作用于移植瘤模型，具有好的药品属性，极高的药效和耐受性。在体内，AC220作用于FLT3-ITD AML鼠模型，抑制FLT3活性,明显延长寿命；作用于依赖FLT3的移植瘤鼠模型时，根除肿瘤；作用于病人原代细胞时，有效抑制FLT3活性。^[1]

激酶实验：^[1]	- 合并激酶实验: 为了测定AC220抑制无靶点激酶的效果，为了比较AC220和其他FLT抑制剂的选择性,使AC220作用于KinomeScan一组402种激酶进行结合试验，其中80%为典型的人类蛋白激酶。测定所有激酶的解离常数。计算绝对选择性和作用于FLT的相对选择性。
细胞实验：^[1]	- 合并 Cell lines: MV4-11和RS4;11细胞 Concentrations: 0-100 nM Incubation Time: 72小时，及2小时 Method: 在增殖实验中，细胞培养在低血清培养基(含0.5% FBS)中过夜, 然后按每孔4×10⁴个细胞接种在96孔板上，然后加入AC220，37^oC下温育72小时。测定细胞活力。测定抑制FLT3自磷酸化的效果, 细胞培养在低血清培养基(含0.5% FBS)过夜，然后按每孔4×10⁵个细胞接种在96孔板上。细胞和AC220一起在37^oC下温育2小时，诱导 RS4;11细胞中FLT3自磷酸化, 加入100 ng/mL FLT3配位体，持续15分钟。转移细胞溶解物到用FLT3抗体包被的96孔板上。然后加入作用于FLT3的生物素化抗体，测定全部FLT3，或者作用于磷酸酪氨酸的抗体，测定FLT3自磷酸化。使用 SULFO标记的链霉亲和素二抗进行电化学发光测定。 (Only for Reference)
动物实验：^[1]	- 合并 Animal Models: 雌性裸鼠或严重联合免疫缺陷鼠 Dosages: 10 mL/kg Administration: 口服饲喂处理 (Only for Reference)

参考文献

[1] Zarrinkar PP, et al. Blood, 2009, 114(14), 2984-2992.

溶解度 (25°C)

体外	DMSO	33 mg/mL (58.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： 15% Captisol	30 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Quizartinib (AC220) SDF

分子量	560.67
化学式	C₂₉H₃₂N₆O₄S
CAS号	950769-58-1
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2020-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04459585	Active not recruiting	Drug: Dabigatran Etexilate Mesylate\|Drug: Quizartinib	Healthy Subjects\|Drug-drug Interaction\|Pharmacokinetics\|Quizartinib	Daiichi Sankyo Co. Ltd.\|Daiichi Sankyo Inc.	September 17 2020	Early Phase 1
NCT04459598	Active not recruiting	Drug: Efavirenz\|Drug: Quizartinib	Healthy Subjects\|Drug-drug Interaction\|Pharmacokinetics\|Quizartinib	Daiichi Sankyo Co. Ltd.\|Daiichi Sankyo Inc.	September 8 2020	Early Phase 1
NCT04473664	Recruiting	Drug: Quizartinib	Hepatic Impairment\|Moderate Impaired Hepatic Function	Daiichi Sankyo Co. Ltd.\|Daiichi Sankyo Inc.	September 29 2020	Phase 1
NCT04209725	Recruiting	Drug: CPX-351\|Drug: Quizartinib	Leukemia Myeloid Acute	SCRI Development Innovations LLC	June 3 2020	Phase 2
NCT02984995	Completed	Drug: Quizartinib	Leukemia Myeloid Acute	Daiichi Sankyo Co. Ltd.\|Daiichi Sankyo Inc.	December 8 2016	Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

常见问题及建议解决方法

问题 1：
Is it possible to alter the captisol concentration to make it more dissolvable i.e 20% or 25% captisol ?
回答：
In 15% Captisol, the compound forms s suspension at 30mg/ml. Increasing the percentage of Captisol will not convert the mixture into solution. You can use suspension for oral gavage feeding.

Target Protein Ligand Inhibitors with Unique Features

用于临床的FLT3抑制剂

Dovitinib (TKI-258, CHIR-258) : Phase III for Metastatic Renal Cell Carcinoma.
最新的FLT3抑制剂

TCS 359 : Potent FLT3 inhibitor with IC50 of 42 nM.

研究领域

产品类型

定制您的化合物库

Quizartinib (AC220)

客户使用Selleck生产的Quizartinib (AC220)发表文献74篇：

产品安全说明书

Target Protein Ligand抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Quizartinib (AC220) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2020-01-06)

技术支持

常见问题及建议解决方法

Target Protein Ligand Inhibitors with Unique Features