STING

抑制剂选择性比较

STING产品

目录号 产品描述 文献引用 实验数据
S1113

GSK690693

GSK690693 是一种泛Akt抑制剂,靶向作用于Akt1/2/3,在无细胞试验中IC50为2 nM/13 nM/9 nM,也对AGC激酶家族:PKA,PrkX和PKC同工酶敏感。GSK690693 也能有效地抑制CAMK家族的 AMPKDAPK3,对应的IC50值分别为50 nM和81 nM。GSK690693 可影响 Unc-51-like autophagy activating kinase 1 (ULK1) 的活性并有效地抑制 STING-dependent IRF3 的激活。Phase 1。

S6494New

CCCP

CCCP是一种氧化磷酸化抑制剂,是线粒体质子载体解偶联剂,可增加线粒体膜对质子的通透性,从而破坏线粒体膜电位。

S6667New

STING inhibitor C-178

C-178是STING的共价抑制剂,与Cys91共价结合。

S6575New

C-176 (STING inhibitor)

STING inhibitor C-176是一种有效的STING抑制剂。STING是细胞内DNA感应通路的主要信号分子。

S7904New

2',3'-cGAMP

2',3'-cGAMP is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). The binding affinity of 2 ’, 3’-cGAMP to STING is 3.79 nM (Kd value).

S7905New

3',3'-cGAMP

3',3'-cGAMP 可激活内质网(ER)内源性受体 stimulator of interferon genes (STING) ,从而诱导抗病毒状态和I型IFN的分泌。

S6652New

H-151

H-151是STING的共价拮抗剂,在人细胞和体内均具有显著的抑制活性。

S1537

DMXAA (Vadimezan)

DMXAA (Vadimezan)是一种vascular disrupting agents (VDA),也是一种DT-diaphorase的竞争性抑制剂,无细胞试验中Ki为20 μM ,IC50为62.5 μM。DMXAA (Vadimezan) 也是一种STING 激动剂,具有潜在的抗肿瘤活性。DMXAA (Vadimezan) 在体外可有效诱导 IFN-βTNF-α 的表达,但对 TNF-α 影响相对较低。DMXAA (Vadimezan)具有抗病毒活性。Phase 3。

S8954New

STING agonist-1 (G10)

STING agonist-1 (G10) 是一种新型人类特异性 STING 激动剂,可在人成纤维细胞中触发 IFN regulatory factor 3 (IRF3)/ type I interferon (IFN) 相关转录。STING agonist-1 (G10) 可有效抑制 Chikungunya virus (CHIKV) 的生长,IC90值为8.01 μM 和 Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV)的复制,IC90为24.57 μM。

S8796New

diABZI STING agonist(compound 3)

STING agonist 1 (compound 3)是有效的非核苷类STING激动剂,对于治疗人类癌症具有巨大潜力。

S3804

Alpha-Mangostin

Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.

目录号 产品描述 文献引用 实验数据
S1113

GSK690693

GSK690693 是一种泛Akt抑制剂,靶向作用于Akt1/2/3,在无细胞试验中IC50为2 nM/13 nM/9 nM,也对AGC激酶家族:PKA,PrkX和PKC同工酶敏感。GSK690693 也能有效地抑制CAMK家族的 AMPKDAPK3,对应的IC50值分别为50 nM和81 nM。GSK690693 可影响 Unc-51-like autophagy activating kinase 1 (ULK1) 的活性并有效地抑制 STING-dependent IRF3 的激活。Phase 1。

S6494New

CCCP

CCCP是一种氧化磷酸化抑制剂,是线粒体质子载体解偶联剂,可增加线粒体膜对质子的通透性,从而破坏线粒体膜电位。

S6667New

STING inhibitor C-178

C-178是STING的共价抑制剂,与Cys91共价结合。

S6575New

C-176 (STING inhibitor)

STING inhibitor C-176是一种有效的STING抑制剂。STING是细胞内DNA感应通路的主要信号分子。

目录号 产品描述 文献引用 实验数据
S7904New

2',3'-cGAMP

2',3'-cGAMP is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). The binding affinity of 2 ’, 3’-cGAMP to STING is 3.79 nM (Kd value).

S7905New

3',3'-cGAMP

3',3'-cGAMP 可激活内质网(ER)内源性受体 stimulator of interferon genes (STING) ,从而诱导抗病毒状态和I型IFN的分泌。

目录号 产品描述 文献引用 实验数据
S6652New

H-151

H-151是STING的共价拮抗剂,在人细胞和体内均具有显著的抑制活性。

目录号 产品描述 文献引用 实验数据
S1537

DMXAA (Vadimezan)

DMXAA (Vadimezan)是一种vascular disrupting agents (VDA),也是一种DT-diaphorase的竞争性抑制剂,无细胞试验中Ki为20 μM ,IC50为62.5 μM。DMXAA (Vadimezan) 也是一种STING 激动剂,具有潜在的抗肿瘤活性。DMXAA (Vadimezan) 在体外可有效诱导 IFN-βTNF-α 的表达,但对 TNF-α 影响相对较低。DMXAA (Vadimezan)具有抗病毒活性。Phase 3。

S8954New

STING agonist-1 (G10)

STING agonist-1 (G10) 是一种新型人类特异性 STING 激动剂,可在人成纤维细胞中触发 IFN regulatory factor 3 (IRF3)/ type I interferon (IFN) 相关转录。STING agonist-1 (G10) 可有效抑制 Chikungunya virus (CHIKV) 的生长,IC90值为8.01 μM 和 Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV)的复制,IC90为24.57 μM。

S8796New

diABZI STING agonist(compound 3)

STING agonist 1 (compound 3)是有效的非核苷类STING激动剂,对于治疗人类癌症具有巨大潜力。

S3804

Alpha-Mangostin

Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.

Tags: STING antagonist | STING inhibitor | STING agonist