Quercetin (NSC 9221)

For research use only. Not for use in humans.

目录号:S2391 别名: Sophoretin, C.I. 75720 中文名称:槲皮素

Quercetin (NSC 9221) Chemical Structure

CAS No. 117-39-5

Quercetin (NSC 9221, Sophoretin, C.I. 75720)是蔬菜水果和白酒中的天然黄酮类化合物,是一种体外重组Sirt1蛋白的激活剂同时也是PI3K抑制剂,IC50为2.4 – 5.4 μM。Quercetin 可诱导凋亡和保护性的自噬。Phase 4。

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客户使用Selleck生产的Quercetin (NSC 9221)发表文献19篇:

产品安全说明书

Sirtuin抑制剂选择性比较

生物活性

产品描述 Quercetin (NSC 9221, Sophoretin, C.I. 75720)是蔬菜水果和白酒中的天然黄酮类化合物,是一种体外重组Sirt1蛋白的激活剂同时也是PI3K抑制剂,IC50为2.4 – 5.4 μM。Quercetin 可诱导凋亡和保护性的自噬。Phase 4。
靶点
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
体外研究

Quercetin是一种基于植物的化学品或植物化学物质,被认为是存在于水果,蔬菜,树叶和谷物中的黄酮醇和一种源于植物的黄酮类化合物。它也可能被用作补品、饮料和食物的配料。在几项研究中,它可能具有抗炎和抗氧化特性,对它广泛潜在的健康益处也正处于研究中。Quercetin (Sophoretin)是一种PI3K抑制剂,IC50为2.4 – 5.4 μM。它能强有力的使PI3K 和Src激酶失效,适度抑制Akt1/2,并轻微影响PKC,p38和ERK1/2。[1] Quercetin抑制TNF诱导的LDH%释放,EC依赖性中性粒细胞对牛肺动脉血管内皮细胞(BPAEC) 的粘附,BPAEC 的DNA合成以及细胞增殖。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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WiDr human colon cells NY\1OmtqS3m2b4TvfIlkcXS7IHHzd4F6 NF\2[3BEgXSxdH;4bYMh\W[oZXP0JI9vKFerRIKgbJVu[W5iY3;sc44h[2WubIOsJGlEPTB;NECuNu69VQ>? NX\JRW06RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEKwNVYxOyd-OEKwNVYxOzxxYU6=
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MDCK NUSzN3BkTnWwY4Tpc44h[XO|YYm= MVjJcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJIlvKE2GQ1ugZ4VtdHNidYPpcochUG:nY3jzeEA{OzN2MjDzeIFqdmmwZzygTWM2OD14LkpOwG0> NXTLRWFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzOVQ5ODBpPkKxN|U1QDByPD;hQi=>
MCF-7 MX NF7CTW5HfW6ldHnvckBie3OjeR?= MlWwTY5pcWKrdHnvckBw\iCEQ2LQJIV5eHKnc4Pl[EBqdiCPQ1[tO{BOYCClZXzsd{B2e2mwZzDIc4VkcHO2IEOzN|QzKHO2YXnubY5oNCCLQ{WwQVcvPs7:TR?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN3NEiwNEc,OjF|NUS4NFA9N2F-
HepG2(2.2.15) NVrW[G0{S3m2b4TvfIlkcXS7IHHzd4F6 NEP2UVI5KGSjeYO= NFzse|VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjiyMlIvOTVrIHPlcIx{KGGodHXyJFgh\GG7czDifUBOXFRiYYPzZZktKEOFNUC9N|gvOc7:TR?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTRyMUGxOUc,OjF2MEGxNVU9N2F-
MDA-MB-231 Mn3kSpVv[3Srb36gZZN{[Xl? MViyNEB2VQ>? NX3Le5VzOzBibXnudy=> M4r2T2lv[3KnYYPlJIlvKGNvRn;zJJBzd3SnaX6g[ZhxemW|c3nvckBqdiCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF1KDJyIIXNJJdqfGirbjCzNEBucW6|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? NXT5bG1lRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OVIzODhpPkKxOlUzOjB6PD;hQi=>
MDA-MB-231 M3ixSGZ2dmO2aX;uJIF{e2G7 M2roZVIxKHWP MljUN|AhdWmwcx?= MWTJcoNz\WG|ZTDpckBG\3JvMTDwdo91\WmwIHX4dJJme3Orb36gbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDheEAzOCC3TTD3bZRpcW5iM{CgcYlveyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> NWfsNYkxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OVIzODhpPkKxOlUzOjB6PD;hQi=>
MDA-MB-231 M2r1c2Fxd3C2b4Ppd{Bie3OjeR?= M{jDUFIxKHWP MVWxNkBpenN? M2PReGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjc4Pld5Nm\CCjczDjcIVifmWmIHPhd5Bie2VvNzDhZ4N2dXWuYYTpc44h[XRiMkCgeW0h[W[2ZYKgNVIhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? M1fQSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkWyNlA5Lz5{MU[1NlIxQDxxYU6=
HepG2 M1npSWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmmyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[nliTWTUJIF{e2G7LDDJR|UxRTNyLkpOwG0> NWj2SnI4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3NlYxPzdpPkKxO|I3ODd5PD;hQi=>
Jurkat MWDGeY5kfGmxbjDhd5NigQ>? NVW5dXQ6OTR3IIXN MnT6PEBpenN? MWjJcohq[mm2aX;uJI9nKGinYYSgd4hw[2tvaX7keYNm\CCKU2C3NEBmgHC{ZYPzbY9vKGmwIHj1cYFvKEq3cnvheEBk\WyuczDheEAyPDVidV2geJJm[XSnZDCyJIhzeyCkZX\vdoUh[mWjdDDzbI9kcyClaHHscIVv\2VibXXhd5Vz\WRiYX\0[ZIhQCCqcoOgZpkhX2W|dHXyckBjdG:2dHnu[y=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd7OEe0PEc,OjF5OUi3OFg9N2F-
HepG2 MkfTSpVv[3Srb36gZZN{[Xl? Mo\CNlQhcHK| NX\ZO3JKUW6qaXLpeIlwdiCxZjDvcIVq[yCjY3nkMYlv\HWlZXSgeJJq\2y7Y3XybYRmKG:4ZYKtZYNkfW23bHH0bY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJJJmdGG2aY\lJJRwKHWwdILlZZRm\CClb370do9tNCCLQ{OwQVE1NjoQvF2= M2LuO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEK0OlkxLz5{MUiyOFY6ODxxYU6=
HepG2 MlnWRY51cW:6aXThcpQh[XO|YYm= NV6xSGg6OjRiaILz MUnBcpRqd3irZHHueEBi[3Srdnn0fUBqdiCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yhd2ynaXOgZYNq\C2rbnT1Z4VlKFKRUzDn[Y5memG2aX;uJIlv[3WkYYTl[EBnd3JiMkSgbJJ{KGK7IFTIR2YuTEFiYnHz[YQh\my3b4LpcYV1emmlIHHzd4F6KHKnbHH0bZZmKHSxIIXueJJm[XSnZDDjc451em:uLDDJR|MxRTNyLklOwG0> NIDaUXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUiyOFY6OCd-MkG4NlQ3QTB:L3G+
MDCK NVnOZnJPSW62aY\pdoFtKGG|c3H5 MYK0JIRigXN? MUDBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDpcoZtfWWwenGgRUB3cXK3czCoRU9{f2mwZT;PTE82OTF2NEWvNlAxPyiKMV6xLUkhV2h5IHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjC0JIRigXNiYomgdZVidnSrdHH0bZZmKFKWLWDDVkwhTUR3ME20PE4z|ryP NFXQZo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGxOVU6OSd-MkKxNVU2QTF:L3G+
HCT116 NWraeW4xT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUnkSJZkPDhiaILz M1flUmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDFzNjDj[YxteyCxdnXy[ZhxemW|c3nu[{BRUTONYXzwbIEhUDFyNEfSJI12fGGwdDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTVwN988US=> MorSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MUK3NlEoRjJ{MkGyO|IyRC:jPh?=
HCT116 NGDyNFlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkC3OFghcHK| NIGyPVFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF03NjgQvF2= M2rzNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkGyO|IyLz5{MkKxNlczOTxxYU6=
HCT116 M2HSRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH7kO4g1QCCqcoO= NGn6XXpIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNib4\ldoV5eHKnc4PpcochWEl|S3HsdIhiKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlPPxE1? NULENYdiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNVI4OjFpPkKyNlEzPzJzPD;hQi=>
HCT116 MWnGeY5kfGmxbjDhd5NigQ>? NYi0VW5iOjVidV2= M3\od|ExKG2rboO= MXfJcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCrbjDoeY1idiCKQ2SxNVYh[2WubIOgeZNqdmdiW{OyVH1CXFBiYYSgNlUhfU1iYX\0[ZIhOTBibXnudy=> MoTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MUK3NlEoRjJ{MkGyO|IyRC:jPh?=
HCT116 NXm1OJhOTnWwY4Tpc44h[XO|YYm= M2iyNlI2KHWP MXKxNEBucW6| MV7Jcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCKMUC0O3IhdXW2YX70JIlvKGi3bXHuJGhEXDFzNjDj[YxteyC3c3nu[{BcOzKSXVHUVEBifCB{NTD1UUBi\nSncjCxNEBucW6| NVTxSIF6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNVI4OjFpPkKyNlEzPzJzPD;hQi=>
HCT116 NIjTVFBHfW6ldHnvckBie3OjeR?= MWiyOUB2VQ>? MmW1TY5pcWKrdHnvckBw\iCSSUPLZYxxcGFiaX6gbJVu[W5iSFPUNVE3KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gRYt1KFOnckS3N{BxcG:|cHjvdplt[XSrb36gZZQhOjVidV2gZpkhcW2vdX7vZoxwfCCjbnHsfZNqew>? MoLNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MUK3NlEoRjJ{MkGyO|IyRC:jPh?=
HCT116 MkThSpVv[3Srb36gZZN{[Xl? Ml\mNlUhfU1? NXToRYFOUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgTFExPDeUIH31eIFvfCCrbjDoeY1idiCKQ2SxNVYh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDheEAzPSC3TTDifUBqdW23bn;icI91KGGwYXz5d4l{ NV7IOWtZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNVI4OjFpPkKyNlEzPzJzPD;hQi=>
human mast cells NFjpPGFHfW6ldHnvckBie3OjeR?= NWeyN4N5UW6qaXLpeIlwdiCxZjDTXWshcW5iaIXtZY4hdWG|dDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hdWG|dDDj[YxtKGSnZ4LhcpVt[XSrb36sJGVEPTB;M{ZOwG0> MljpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{NUeyNVMoRjJ{MkW3NlE{RC:jPh?=
Huh7.5.1 NHPUXFhCdnSrdnnyZYwh[XO|YYm= MYm3NkBpenN? NXfMdoQ2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOYIFrGTE0yKEp|OUnFUUBqdm[nY4Tl[EBqdiCKdX3hckBJfWh5LkWuNUBk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB5MjDodpMh[nliRVfGVEBie3OjeTygSWM2OD1zOT64{txO NI[2WVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS0OVMzQCd-MkK0OFU{Ojh:L3G+
HT22 NWHiXYZ2VmW3cn;wdo91\WO2aY\lJIF{e2G7 NWOybGJkOjVidV2= NWHQdIxCOjRiaILz M3znVm5mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHfseZRidWG2ZTDpcoR2[2WmIH;4bYRifGm4ZTDzeJJme3NiaX6gcY92e2ViaHnwdI9k[W2yYXygTHQzOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBifCB{NTD1UUBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5 NHvOVGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[yOFg5OCd-MkK2NlQ5QDB:L3G+
22Rv1 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2fOcmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iMkLSelEh[2WubIOgbY5kfWKjdHXkJJVxKHSxIEG0OEBpenNiYomgR492dHSncjDwZZJ1cWOuZTDjc5VvfCCjbnSgd4l7\SCjbnHsfZpmeixiSVO1NF0yPS53zszN NYjTTHFoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3PFk5OTJpPkKyO|g6QDF{PD;hQi=>
RAW264.7 M1vuWWZ2dmO2aX;uJIF{e2G7 MnfoOVAhfU1? NIf2dWU{KGi{cx?= NInmZZNC[3SrdnH0bY9vKG:oIF7y[lIhcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgZZN{\XO|ZXSgZZMh[3m2b4PvcIlkKGGlY4XteYxifGmxbjDheEA2OCC3TTDh[pRmeiB|IHjyd{BjgSCZZYP0[ZJvKGKub4T0bY5oKGGwYXz5d4l{ NIOxenc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K5OFI5Pid-MkOyPVQzQDZ:L3G+
RAW264.7 NUTnNY1ITnWwY4Tpc44h[XO|YYm= NYr6TpA1PTBidV2= MmjNN{BpenN? NEH4RodC[3SrdnH0bY9vKG:oIF7y[lIhcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgZZN{\XO|ZXSgZZMhdnWlbHXhdkBi[2O3bYXsZZRqd25iYYSgOVAhfU1iYX\0[ZIhOyCqcoOgZpkhX2W|dHXyckBjdG:2dHnu[{BidmGueYPpdy=> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ7NEK4Okc,OjN{OUSyPFY9N2F-
ARPE19 NV\TNmxTTnWwY4Tpc44h[XO|YYm= NV7rbnd1OjBidV2= MkfmNVgh\GG7cx?= NE[4dWFKdmirYnn0bY9vKG:oIHnueJJi[2WubIXsZZIhSTKHIIDoc5Rwd3irZHH0bY9vKGmwIHj1cYFvKEGUUFWxPUBk\WyuczDheEAzOCC3TTDh[pRmeiBzODDkZZl{ MkTaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|NE[4OlYoRjJ|M{S2PFY3RC:jPh?=
MV4-11 MVTDfZRwfG:6aXPpeJkh[XO|YYm= MoizO|IhcHK| M3PDeWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1XPC1zMTDj[YxteyCqYYLic5JqdmdiRlzUN{BufXSjdHnvckBi\nSncjC3NkBpenNiYomgeIV1emG8b3zpeY0h[mG|ZXSgSZohS3mWb4igZ4VtdCC4aXHibYxqfHliYYPzZZktKEeLNUC9NVMvOc7:TR?= M3LKNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEGxNFc{Lz5{M{SxNVA4OzxxYU6=
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HEK293 MnnCSpVv[3Srb36gZZN{[Xl? MkP6N|AhdWmwcx?= Mn\DTY5pcWKrdHnvckBw\iCqdX3hckBVWlCFNTDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCpYXTvcIlvcXWvLXnu[JVk\WRiY3HsZ4l2dSCnboTyfUBi\nSncjCzNEBucW6|IHL5JIZtfW9vNDDkfYUh[mG|ZXSg[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyPU[uOe69VQ>? M{fF[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUSzNFMxLz5|MEm0N|A{ODxxYU6=
EPG85-257RDB MmTiSpVv[3Srb36gZZN{[Xl? NULOflFvPzJiaILz NGe0ToJFd3ewcnXneYxifGmxbjDv[kBCSkOEMTDn[Y5mKGW6cILld5Nqd25iaX6gbJVu[W5iRWDHPFUuOjV5UlTCJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCUVD3QR3Ih[W6jbInzbZMtKEmFNUC9NVLPxE1? NWq2fXp3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxNFM6ODRpPkOxNVA{QTB2PD;hQi=>
PC12 NInLUmlP\XW{b4Dyc5Rm[3SrdnWgZZN{[Xl? NGfZUGwyOCC3TR?= MnTHN{BpenN? M2DFd25mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDpckBz[XRiUFOxNkBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5QhUDKRMj3pcoR2[2WmIHP5eI91d3irY3n0fUBifCBzMDD1UUBxemVvaX7jeYJifGWmIH\vdkA{KGi{czDi[YZwemViSELPNkBi\GSrdHnvckBidmRibXXhd5Vz\WRiYX\0[ZIhOTJiaILzJIJ6KE2WVDDhd5NigQ>? NFzXTmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUGyPFk6OCd-M{GxNlg6QTB:L3G+
SH-SY5Y NWnDR4Q5VmW3cn;wdo91\WO2aY\lJIF{e2G7 MlXINVAxKHWP NWTtVWdpOSCqch?= M3zjb25mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFiyU|IucW6mdXPl[EBwgGmmYYTpeoUhe3S{ZYPzJIlvKGi3bXHuJHNJNVO\NWmgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKFKRUzDn[Y5memG2aX;uJIF1KDFyMDD1UUBxemWrbnP1ZoF1\WRiZn;yJFEhcHJiZn;scI94\WRiYomgSGNHUC2GQTDh[IRqfGmxbjDmc5IhOzBibXnud{BidmRic4Xid4VyfWWwdDDjc{11emWjdH3lcpQhf2m2aDDjc41xd3WwZDDhcoQhUDKRMjDmc5IhOw>? MkPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzNUi3OVQoRjNzMUW4O|U1RC:jPh?=
HT22 M{LuNm5mfXKxcILveIVkfGm4ZTDhd5NigQ>? M3PqUFI2KHWP Moj0NlQhcHK| MXTO[ZVzd3C{b4TlZ5Rqd25iYXfhbY5{fCCpbIX0ZY1ifGVvaX7keYNm\CClZXzsJIRm[XSqIHnuJI1wfXOnIFjUNlIh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iY3XscEB3cWGkaXzpeJkh[XRiMkWgeW0hdWWjc4Xy[YQh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfS=> NXfIOFA{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G2NFkyOTVpPkOxOlA6OTF3PD;hQi=>
HT22 Ml[1UoV2em:ycn;0[YN1cX[nIHHzd4F6 M2n3XVI2KHWP NWm2cG05OjRiaILz M3K0VG5mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDheEBud3W|ZTDIWFIzKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDncJV1[W2jdHWtbY5lfWOnZDDvfIll[XSrdnWgd5Rz\XO|IHL5JI1m[XO3cnnu[{Bk\WyuII\pZYJqdGm2eTDheEAzPSC3TTDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCPVGSgZZN{[Xl? MkTTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF4MEm2NFgoRjNzNkC5OlA5RC:jPh?=
PANC1 M3PCTGFvfGlvYYXzeIVzcXS7IHHzd4F6 NFTkZ4QzPCCqcoO= NYrlco9rSW62aT3heZN1\XKrdImgZYN1cX[rdImgZYdicW6|dDDueZRzcWWwdD3k[ZBzcX[nZDDoeY1idiCSQV7DNUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHTlZZRpKGmwY4XiZZRm\CCob4KgNlQhcHK|IHL5JHdUXC16IHHzd4F6NCCSQ{WwQVIyNjkQvF2= MkLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF4OEKxNlYoRjNzNkiyNVI3RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Bcl-2 / Bax / Bcl-xl ; 

PubMed: 27175602     


Analysis of intrinsic apoptosis-related molecules. BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Total proteins were analyzed by western blotting with anti-Bcl-2, anti-BAX, anti-Bcl-xL and anti-tubulin antibodies.

p-p53 / p53 / p21 ; 

PubMed: 27175602     


BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Whole cell lysates were analyzed by western blotting with anti-p-p53, anti-p53, anti-p21 and anti-tubulin antibodies.

p-JAK1 / p-STAT3 / STAT3 / VEGF ; 

PubMed: 27175602     


BT-474 cells were treated with quercetin (0–60 µM) for 24 h. Whole cell lysates were analyzed by western blotting with anti-p-JAK1, anti-p-STAT3, anti-STAT3, anti-VEGF, and anti-tubulin antibodies.

Her-2 / p-PI3K / p-Akt / Akt ; 

PubMed: 18655187     


SK-Br3 cells were treated with 100 μM or 200 μM of quercetin for the indicated days. 

27175602 18655187
Growth inhibition assay
Cell viability ; 

PubMed: 27175602     


BT-474 cells were treated with different doses of quercetin and genistein (0–100 µM). After 72 h, cell viability was assessed using a cell proliferation assay.

Cell viability ; 

PubMed: 28280414     


MDA-MB-231 cells were treated with various concentration of quercetin (2.5~80 µM) for 24 h, 48 h and 72 h. Cell viability was assessed by MTT assay. *p<0.001, significant difference compared to control.

27175602 28280414
体内研究 Quercetin (75 mg/kg)与2-Methoxyestradiol结合增强对人前列腺癌LNCaP和PC-3细胞异种移植瘤生长的抑制。[3] LD50: >3000mg/kg (i.g.) [4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
6mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 302.24
化学式

C15H10O7

CAS号 117-39-5
储存条件 粉状
溶于溶剂
别名 Sophoretin, C.I. 75720

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03989271 Recruiting Drug: Quercetin Chronic Obstructive Pulmonary Disease Temple University|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) October 1 2019 Phase 1|Phase 2
NCT01708278 Completed Drug: Quercetin|Other: Placebo - sugar chew Chronic Obstructive Pulmonary Disease University of Michigan|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) February 2014 Phase 1
NCT01720147 Recruiting Drug: Quercetin (dietary supplement) Fanconi Anemia Children''s Hospital Medical Center Cincinnati|Food and Drug Administration (FDA) July 2012 Phase 1
NCT01438320 Completed Dietary Supplement: Quercetin Chronic Hepatitis C University of California Los Angeles|American Association for Cancer Research|Tower Cancer Research Foundation|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) July 2011 Phase 1

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项

Sirtuin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID