Quercetin (NSC 9221)

目录号:S2391 别名: Sophoretin, C.I. 75720 中文名称:槲皮素

仅限科研使用

Quercetin (NSC 9221, Sophoretin, C.I. 75720)是蔬菜水果和白酒中的天然黄酮类化合物,是一种体外重组Sirt1蛋白的激活剂同时也是PI3K抑制剂,IC50为2.4 – 5.4 μM。Quercetin 可诱导凋亡和保护性的自噬。Phase 4。

Quercetin (NSC 9221) Chemical Structure

CAS: 117-39-5

规格 价格 库存 购买数量
RMB 647.01 现货
大包装 有超大折扣

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客户使用Selleck生产的Quercetin (NSC 9221)发表文献26篇:

产品安全说明书

Sirtuin抑制剂选择性比较

相关Sirtuin产品

生物活性

产品描述 Quercetin (NSC 9221, Sophoretin, C.I. 75720)是蔬菜水果和白酒中的天然黄酮类化合物,是一种体外重组Sirt1蛋白的激活剂同时也是PI3K抑制剂,IC50为2.4 – 5.4 μM。Quercetin 可诱导凋亡和保护性的自噬。Phase 4。
靶点
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
点击更多
2.4 μM 3.0 μM
体外研究

Quercetin是一种基于植物的化学品或植物化学物质,被认为是存在于水果,蔬菜,树叶和谷物中的黄酮醇和一种源于植物的黄酮类化合物。它也可能被用作补品、饮料和食物的配料。在几项研究中,它可能具有抗炎和抗氧化特性,对它广泛潜在的健康益处也正处于研究中。Quercetin (Sophoretin)是一种PI3K抑制剂,IC50为2.4 – 5.4 μM。它能强有力的使PI3K 和Src激酶失效,适度抑制Akt1/2,并轻微影响PKC,p38和ERK1/2。[1] Quercetin抑制TNF诱导的LDH%释放,EC依赖性中性粒细胞对牛肺动脉血管内皮细胞(BPAEC) 的粘附,BPAEC 的DNA合成以及细胞增殖。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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ANN-1 M3zTZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> MXjDfZRwfG:6aXOg[YZn\WO2IH;uJJYu[WKuIITyZY5{\m:{bXXkJI12emmwZTDBUm4uOSClZXzsd{whUUN3ME2zNk42|ryP MmXMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDJyMU[wN{c,QDJyMU[wN|ww[T5?
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MDCK NXzyS4JkTnWwY4Tpc44h[XO|YYm= NV7BdIFpUW6qaXLpeIlwdiCxZjDCR3JRKGW6cILld5Nm\CCrbjDNSGNMKGOnbHzzJJV{cW6pIFjv[YNpe3RiM{OzOFIhe3SjaX7pcoctKEmFNUC9Ok46|ryP MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN3NEiwNEc,OjF|NUS4NFA9N2F-
MCF-7 MX M1\xRmZ2dmO2aX;uJIF{e2G7 MYfJcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJIlvKE2FRj23JG1ZKGOnbHzzJJV{cW6pIFjv[YNpe3RiM{OzOFIhe3SjaX7pcoctKEmFNUC9O{43|ryP M37nN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{W0PFAxLz5{MUO1OFgxODxxYU6=
HepG2(2.2.15) NHHLPGVEgXSxdH;4bYNqfHliYYPzZZk> M2LJTlgh\GG7cx?= MoL4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJqMj6yMlE2MSClZXzsd{Bi\nSncjC4JIRigXNiYomgUXRVKGG|c3H5MEBESzVyPUO4MlHPxE1? NIrYVYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUSwNVEyPSd-MkG0NFEyOTV:L3G+
MDA-MB-231 NETMeVZHfW6ldHnvckBie3OjeR?= NUDxZYRoOjBidV2= NIK4b|M{OCCvaX7z M{j5RWlv[3KnYYPlJIlvKGNvRn;zJJBzd3SnaX6g[ZhxemW|c3nvckBqdiCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF1KDJyIIXNJJdqfGirbjCzNEBucW6|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ3MkKwPEc,OjF4NUKyNFg9N2F-
MDA-MB-231 M1jQPWZ2dmO2aX;uJIF{e2G7 NGjv[pAzOCC3TR?= NEfOVY8{OCCvaX7z M4rkZ2lv[3KnYYPlJIlvKEWpcj2xJJBzd3SnaX6g[ZhxemW|c3nvckBqdiCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF1KDJyIIXNJJdqfGirbjCzNEBucW6|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? M1PucVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkWyNlA5Lz5{MU[1NlIxQDxxYU6=
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HepG2 MoT6R5l1d3SxeHnjbZR6KGG|c3H5 MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OzBwOd88US=> NUT5WplkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3NlYxPzdpPkKxO|I3ODd5PD;hQi=>
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HepG2 NWLlRmt[TnWwY4Tpc44h[XO|YYm= M4H0WlI1KGi{cx?= NWnnOJdWUW6qaXLpeIlwdiCxZjDvcIVq[yCjY3nkMYlv\HWlZXSgeJJq\2y7Y3XybYRmKG:4ZYKtZYNkfW23bHH0bY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJJJmdGG2aY\lJJRwKHWwdILlZZRm\CClb370do9tNCCLQ{OwQVE1NjoQvF2= NH3HXIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUiyOFY6OCd-MkG4NlQ3QTB:L3G+
HepG2 NUTrVWk{SW62aX;4bYRidnRiYYPzZZk> MXyyOEBpenN? M4XnemFvfGmxeHnkZY51KGGldHn2bZR6KGmwIHj1cYFvKEincFeyJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCxbHXpZ{Bi[2mmLXnu[JVk\WRiUl;TJIdmdmW{YYTpc44hcW6ldXLheIVlKG[xcjCyOEBpenNiYomgSGhETi2GQTDiZZNm\CCobIXvdolu\XS{aXOgZZN{[XlicnXsZZRqfmVidH:geY51emWjdHXkJINwdnS{b3ysJGlEOzB;M{CuPO69VQ>? NWn2fpVFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4NlQ3QTBpPkKxPFI1PjlyPD;hQi=>
MDCK M{jqZWFvfGm4aYLhcEBie3OjeR?= Ml\JOEBl[Xm| NV3oOW1JSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcW6obIXlcppiKEFidnnyeZMhMEFxc4fpcoUwV0hxNUGxOFQ2NzJyMEeoTFFPOSlrIF;oO{Bqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhPCCmYYnzJIJ6KHG3YX70bZRifGm4ZTDSWE1RS1JuIFXEOVA:PDhwMt88US=> Mk\FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzMUW1PVEoRjJ{MUG1OVkyRC:jPh?=
HCT116 MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUC0PEBpenN? NWXYb484T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKFCLM1vhcJBp[SCKMUC0O3IhdXW2YX70JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NT63{txO Mmm2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MUK3NlEoRjJ{MkGyO|IyRC:jPh?=
HCT116 MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWW0PEBpenN? MYnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME22MlfPxE1? NUfiOGVZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNVI4OjFpPkKyNlEzPzJzPD;hQi=>
HCT116 NVzDXoE5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVu0PEBpenN? MUDHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIR3QyOTZiY3XscJMhd3[ncnX4dJJme3OrbnegVGk{U2GucHjhJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkROwG0> Mlf2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MUK3NlEoRjJ{MkGyO|IyRC:jPh?=
HCT116 MlrFSpVv[3Srb36gZZN{[Xl? NIC5OlczPSC3TR?= NFPLPVAyOCCvaX7z NH3JTlRKdmirYnn0bY9vKG:oIGDJN2tidHCqYTDpckBpfW2jbjDIR3QyOTZiY3XscJMhfXOrbnegX|MzWF2DVGCgZZQhOjVidV2gZYZ1\XJiMUCgcYlvew>? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJzMkeyNUc,OjJ{MUK3NlE9N2F-
HCT116 MlLtSpVv[3Srb36gZZN{[Xl? M3\UZVI2KHWP NGrnWGEyOCCvaX7z Ml\mTY5pcWKrdHnvckBw\iCSSUPLZYxxcGFiSEGwOFdTKG23dHHueEBqdiCqdX3hckBJS1RzMU[gZ4VtdHNidYPpcochYzN{UG3BWHAh[XRiMkWgeW0h[W[2ZYKgNVAhdWmwcx?= MnT3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MUK3NlEoRjJ{MkGyO|IyRC:jPh?=
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human mast cells NFvGeoNHfW6ldHnvckBie3OjeR?= NIXQ[pFKdmirYnn0bY9vKG:oIGPZT{BqdiCqdX3hckBu[XO2IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBu[XO2IHPlcIwh\GWpcnHueYxifGmxbjygSWM2OD1|Nd88US=> MoKwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{NUeyNVMoRjJ{MkW3NlE{RC:jPh?=
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RAW264.7 NGHYdVVHfW6ldHnvckBie3OjeR?= NVPIfVNsPTBidV2= NH\uTZg{KGi{cx?= M17tRmFkfGm4YYTpc44hd2ZiToLmNkBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BkgXSxc3;sbYMh[WOldX31cIF1cW:wIHH0JFUxKHWPIHHmeIVzKDNiaILzJIJ6KFenc4Tldo4h[myxdITpcoch[W6jbInzbZM> NEToflI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K5OFI5Pid-MkOyPVQzQDZ:L3G+
RAW264.7 MnTISpVv[3Srb36gZZN{[Xl? M3rad|UxKHWP MmewN{BpenN? NFzacVZC[3SrdnH0bY9vKG:oIF7y[lIhcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgZZN{\XO|ZXSgZZMhdnWlbHXhdkBi[2O3bYXsZZRqd25iYYSgOVAhfU1iYX\0[ZIhOyCqcoOgZpkhX2W|dHXyckBjdG:2dHnu[{BidmGueYPpdy=> NHjocoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K5OFI5Pid-MkOyPVQzQDZ:L3G+
ARPE19 NXrsdIRTTnWwY4Tpc44h[XO|YYm= MkfpNlAhfU1? M4XrZlE5KGSjeYO= NWTxTo1sUW6qaXLpeIlwdiCxZjDpcpRz[WOnbHz1cIFzKEF{RTDwbI91d2:6aXTheIlwdiCrbjDoeY1idiCDUmDFNVkh[2WubIOgZZQhOjBidV2gZYZ1\XJiMUig[IF6ew>? M2XkdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{S2PFY3Lz5{M{O0Olg3PjxxYU6=
MV4-11 M{T6SGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUC3NkBpenN? MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMhcGG{Yn;ybY5oKE[OVEOgcZV1[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IITleJJigm:uaYXtJIJie2WmIFX6JGN6XG:6IHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBIUTVyPUGzMlHPxE1? MmfDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MUGwO|MoRjJ|NEGxNFc{RC:jPh?=
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Assay
Methods Test Index PMID
Western blot Her-2 / p-PI3K / p-Akt / Akt p-JAK1 / p-STAT3 / STAT3 / VEGF p-p53 / p53 / p21 Bcl-2 / Bax / Bcl-xl 18655187 27175602
Growth inhibition assay Cell viability Cell viability 28280414 27175602
体内研究 Quercetin (75 mg/kg)与2-Methoxyestradiol结合增强对人前列腺癌LNCaP和PC-3细胞异种移植瘤生长的抑制。[3] LD50: >3000mg/kg (i.g.) [4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度(25°C)

体外

体内

从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O

6mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 302.24
化学式

C15H10O7

CAS号 117-39-5
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04907253 Recruiting Drug: Quercetin|Drug: Placebo Coronary Artery Disease Montreal Heart Institute June 4 2021 Phase 2
NCT04474626 Withdrawn Drug: Isoquercetin Sickle Cell Disease|Sickle Cell-Beta0-Thalassemia Jeffrey Zwicker MD|Quercegen Pharmaceuticals|Dana-Farber Cancer Institute December 2020 Phase 2
NCT04063124 Active not recruiting Drug: Dasatinib + Quercetin Alzheimer Disease The University of Texas Health Science Center at San Antonio|Mayo Clinic February 14 2020 Phase 1|Phase 2
NCT03989271 Recruiting Drug: Quercetin Chronic Obstructive Pulmonary Disease Temple University|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) October 1 2019 Phase 1|Phase 2
NCT02446795 Unknown status Drug: Sunitinib|Drug: Isoquercetin|Drug: Placebo Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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