Pictilisib (GDC-0941)

For research use only. Not for use in humans.

目录号:S1065 别名: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) 是一种有效的PI3Kα/δ抑制剂,在无细胞试验中IC50为 3 nM,对p110β (11倍)和p110γ (25倍)具有适度的选择性。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1972.48 现货
RMB 986.88 现货
RMB 1390.74 现货
RMB 3026.17 现货
RMB 7926.11 现货
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客户使用Selleck生产的Pictilisib (GDC-0941)发表文献294篇:

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Pictilisib (GDC-0941) 是一种有效的PI3Kα/δ抑制剂,在无细胞试验中IC50为 3 nM,对p110β (11倍)和p110γ (25倍)具有适度的选择性。Phase 2。
靶点
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
体外研究

GDC-0941也等效作用于PI3Kα和 PI3Kδ和PI3Kα突变型E545-K和H1047-R,也选择性作用于PI3Kβ(10倍)和 PI3Kγ(25倍), 选择性更高地作用于PI3K II, III, 和IV类成员,包括, C2β, Vps34, DNA-PK和mTOR。GDC-0941 作用于U87MG, PC3, 和 MDA-MB-361 细胞,有效抑制Akt磷酸化,IC50分别为46 nM, 37 nM,和 28 nM。GDC-0941抑制U87MG, A2780, PC3, 和MDA-MB-361细胞增殖,IC50分别为 0.95 μM, 0.14 μM, 0.28 μM, 和0.72 μM。[1]GDC-0941处理,有效抑制对Trastuzumab敏感和不敏感的HER2扩增细胞增殖,IC50为149-944 nM,与 Trastuzumab敏感性无关。GDC-0941抑制含PIK3CA突变的HER2扩增的细胞增殖,IC50<500 nM, 且有效抑制抗trastuzumab 的HER2 扩增乳腺癌细胞增殖和活力。[2]GDC-0941 显著抑制HCT116, DLD1和 HT29细胞生长,GI50分别为1081 nM, 1070 nM 和157 nM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 MnK0T4lv[XOnIFHzd4F6 MYKxJIg> NUnxO|hzTE2VTx?= MWrJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGSnbIThJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCwN{DPxE1? MofyNVg4PTR4NUS=
Sf9 NHvoSFRMcW6jc3WgRZN{[Xl? MmTtNUBp MYHEUXNQ M3L4S2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYnX0ZUBJOTB2Nz3SJI12fGGwdDDlfJBz\XO|ZXSgbY4hW2Z7IHPlcIx{KGOxZYjwdoV{e2mwZzDwPFVidHCqYTD3bZRpKEmFNUCgc4YhOC5yMEOg{txO MkDYNVg4PTR4NUS=
Sf9 NYfH[G9tU2mwYYPlJGF{e2G7 MWWxJIg> MUnEUXNQ MXXJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgSVU1PS2NIH31eIFvfCCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[SC5aYToJGlEPTBib3[gNE4xODNizszN NGT4T2YyQDd3NE[1OC=>
Sf9 NHzYbIlMcW6jc3WgRZN{[Xl? NFHX[G8yKGh? NX30eHlFTE2VTx?= MULJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMEOzJO69VQ>? NHq4RZUyQDd3NE[1OC=>
Sf9 NHzIXHlMcW6jc3WgRZN{[Xl? M3zHe|EhcA>? MmHmSG1UVw>? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGGucHjhJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjh M3rD[|E5PzV2NkW0
MDA-MB-361 MVHGeY5kfGmxbjDBd5NigQ>? MoKyNkBp M2m3U2ROW09? NHLiPItKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIF3ERU1OSi1|NkGgZ4VtdHNid3n0bEBRUUt|Q1GgSVU1PS2NIH31eIF1cW:wIIfpeIghUUN3MDDv[kAxNjB{ODFOwG0> MXWxPFc2PDZ3NB?=
PC3 MVrGeY5kfGmxbjDBd5NigQ>? MUeyJIg> M2rUbmROW09? MWTJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIGDUSW4udnWubDDoeY1idiCSQ{OgZ4VtdHNid3n0bEBKSzVyIH;mJFAvODN5IN88US=> NXXre49iOTh5NUS2OVQ>
U87MG M1T0UWZ2dmO2aX;uJGF{e2G7 MVSyJIg> NVjGVoxxTE2VTx?= MWrJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIGDUSW4udnWubDDoeY1idiCXOEfNS{Bk\WyuczD3bZRpKEmFNUCgc4YhOC5yNE[g{txO MYSxPFc2PDZ3NB?=
MDA-MB-361 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HRR|k3KGh? MWfEUXNQ MoHYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOzZzIHPlcIx{KHerdHigVGlMO0ODIFW1OFUuUyCvdYTheIlwdiC5aYToJGlEPTBib3[gNE44OiEQvF2= NVnyb3ZCOTh5NUS2OVQ>
A2780 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzmPVYhcA>? NHXCVm9FVVOR NXTXdZFnSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{B4cXSqIGDJT|NESSCjbnSgVHRGViCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4yPCEQvF2= M33VbFE5PzV2NkW0
PC3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;vfXU6PiCq MlfBSG1UVw>? Moj5TWM2OD1yLkK4JO69VQ>? M1\CelE5PzV2NkW0
U87MG NELJOFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjBTYI{QTZiaB?= NGTse2pFVVOR NWCxe2dUUUN3ME2wMlk2KM7:TR?= NGjxT4UyQDd3NE[1OC=>
Sf9 MVHLbY5ie2ViQYPzZZk> NI\iW|k{OCCvaX6= MnOzSG1UVw>? NFrZU4dKdmirYnn0bY9vKG:oIHj1cYFvKFCLM1vnZY1u[SCneIDy[ZN{\WRiYYPz[ZN{\WRiYYOgZY1wfW62IH;mJGFVWCClb37zeY1m\CC5aYToJGlEPTBib3[gNE4xPDJizszN NYi1Z4E2OjJ3NEizOFI>
RAW 264.7 MlywT4lv[XOnIFHzd4F6 M1fKU|kxKG2rbh?= Mo\KSG1UVw>? MVLJcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBCU1RicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlI6QCEQvF2= MUSyNlU1QDN2Mh?=
Sf9 NGfNRZVMcW6jc3WgRZN{[Xl? NIPmNVcyKGh? MnjYTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4JmfGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKFOIOTDj[YxteyC5aYToJGlEPTBib3[gNE4xOTdizszN MWiyN|U1ODZ2NR?=
Sf9 Mn[1T4lv[XOnIFHzd4F6 NFH1VosyKGh? MmTnTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4RmdHSjIHX4dJJme3OnZB?= NUW5ZlRoOjN3NEC2OFU>
Sf9 MVfLbY5ie2ViQYPzZZk> NXvxU4lqOSCq NXLHPY5wUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2ejbX3hJIV5eHKnc4Pl[C=> MmDBNlM2PDB4NEW=
Sf9 NHTKd45McW6jc3WgRZN{[Xl? MlnRNUBp NYPTenNvUW6qaXLpeIlwdiCxZjDHV3Qu\nW|ZXSgbJVu[W5icnXjc41jcW6jboSgVGk{U2GucHjhJIV5eHKnc4Pl[C=> MYOyN|U1ODZ2NR?=
SKOV3 M3XGZmtqdmG|ZTDBd5NigQ>? M1;4eFEh|ryP MX6xJIg> NVPoTFByTE2VTx?= NVjB[FR6UW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbh?= NYHlPYNPOjN|NkCzOFg>
MCF7 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX:xJO69VQ>? MkXBPVYhcA>? NHraOZlFVVOR M{nYSWdKPTB;MD6wO|AzKM7:TR?= M37M[VI{OzZyM{S4
SKOV3 NIXkXYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\mRVEh|ryP NXm2epFIQTZiaB?= MoPuSG1UVw>? MlvVS2k2OD1yLkG0O|Yh|ryP M3XxcFI{OzZyM{S4
PC3 M3ntfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTMO|IhcA>? NFPhNnNFVVOR Ml65TWM2OD1yLkK4JO69VQ>? MlKzNlE6QDF5MUS=
MCF7.1 M2XnUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfPT4E4OiCq NXjZbItNTE2VTx?= NYPH[3UzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4NjFiY3XscJMh\XiycnXzd4lv\yCKRWKyJIdmdmVid3n0bEBKSzVyIH;mJFAvOjhizszN NX3sVINLOjF7OEG3NVQ>
MCF7-neo/Her2 M376UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zE[lczKGh? M1Lwb2ROW09? NXfjSlhHUUN3ME2wMlI6KM7:TR?= MUSyN|Y3OjlyMx?=
MCF7-neo/Her2 MkD0T4lv[XOnIFHzd4F6 NVjT[HlFUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIFHLWEBxcG:|cHjvdplt[XSrb36gZZQhWzR5MzD3bZRpKEmFNUCgc4YhOC5yMEeg{txO NVnrZo57OjN4NkK5NFM>
PC3 MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXJ[ItTPzJiaB?= NIHmZ2ZFVVOR NXvZbYMzTUN3ME2wMlM1KM7:TR?= M1P3[|IyQTh3NkO5
MCF7.1 M2\nWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUm3NkBp MkHUSG1UVw>? MkHMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BRUTONYXzwbIEhdXW2YX70JJdqfGhiRVO1NEBw\iByLkO5JO69VQ>? M1zDclIyQTh3NkO5
PC3 M4nndWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInT[ZY4OiCq NHmzR4JFVVOR MmPJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiZHXmbYNq\W62IHnuJHBVTU5id3n0bEBKSzVyIH;mJFAvOzlizszN NEOyNW4zODB3ME[2PS=>
MCF7.1 NWS2NotST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGW1O444OiCq MoK5SG1UVw>? M17oe2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochWEl|S3HsdIhiKG23dHHueEB4cXSqIFnDOVAhd2ZiMD6zOEDPxE1? MojFNlAxPTB4Nkm=
MCF7.1 NHT0VXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3VeIg4OiCq MVLFR|UxRTBwN{Kg{txO NV7HbpVTOjB|NE[2OVY>
NCI-H1975 NWDMVIF7S3m2b4TvfIlkKEG|c3H5 NVLiWpF4PzJiaB?= NWjueJQ6UUN3ME2wMlI4KM7:TR?= M1PXZlI{ODV7NUS1
H460 NXvzTIxvS3m2b4TvfIlkKEG|c3H5 M17sR|czKGh? NEW2[41KSzVyPUCuPFch|ryP NXzhXFd{OjNyNUm1OFU>
HT-29 M{PU[WN6fG:2b4jpZ{BCe3OjeR?= NF3YXIc4OiCq MX7JR|UxRTBwNk[g{txO MX:yN|A2QTV2NR?=
HepG2 NH[yRWhEgXSxdH;4bYMhSXO|YYm= MVq3NkBp NFGzblJKSzVyPUGg{txO M{PFWVI{ODV7NUS1
SGC7901 MVXDfZRwfG:6aXOgRZN{[Xl? NGflPZk4OiCq Mke2TWM2OD1zLkig{txO NVOyeZhQOjNyNUm1OFU>
NCI-H226 MmT3R5l1d3SxeHnjJGF{e2G7 M{O2SFczKGh? MnPSTWM2OD1{Lkmg{txO NHTPe44zOzB3OUW0OS=>
A549 MV;DfZRwfG:6aXOgRZN{[Xl? Ml3hO|IhcA>? MX;JR|UxRTZwOTFOwG0> MX:yN|A2QTV2NR?=
U87MG MYrDfZRwfG:6aXOgRZN{[Xl? NELMSJU4OiCq NHKyPWVKSzVyPUeuO|ch|ryP NHvDO40zOzB3OUW0OS=>
HBC4 Mmj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPsc4dIUTVyPT22MlA{KE1? MVWyNlM{PjJ2Nh?=
BSY1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELPOIttd2eJSUWwQU03NjlyIF2= MmXvNlI{OzZ{NE[=
HBC5 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj2NlRCdG:pR1m1NF0uPi54MDDN NXPPVHdvOjJ|M{[yOFY>
MCF7 M{mzR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXX3Rph3dG:pR1m1NF0uPy5|MzDN M1;jclIzOzN4MkS2
MDA-MB-231 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT6cI9oT0l3ME2tOU41PiCP Mn[xNlI{OzZ{NE[=
U251 MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnsc4dIUTVyPT21MlUxKE1? MXmyNlM{PjJ2Nh?=
SF268 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLlfnJHdG:pR1m1NF0uPS5|OTDN NEDQT44zOjN|NkK0Oi=>
SF295 MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTaTHFYdG:pR1m1NF0uPi5|NzDN MVeyNlM{PjJ2Nh?=
SF539 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX0XJptd2eJSUWwQU03NjVyIF2= MlnNNlI{OzZ{NE[=
SNB75 NYHLTYg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\sc4dIUTVyPT23MlExKE1? NY\RRmtbOjJ|M{[yOFY>
SNB78 Mne0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfxcI9oT0l3ME2tOk42OiCP NIi5UWozOjN|NkK0Oi=>
HCC2998 NFXYbHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\EcI9oT0l3ME2tOk4zQSCP Mki0NlI{OzZ{NE[=
KM12 NGLxUJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVP2SoYydG:pR1m1NF0uPS55NjDN Mn\rNlI{OzZ{NE[=
HT-29 NETReVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITud|Rtd2eJSUWwQU03NjNyIF2= NGTaeJYzOjN|NkK0Oi=>
HCT15 Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUOxSJo6dG:pR1m1NF0uPi5zMjDN MVqyNlM{PjJ2Nh?=
HCT116 M372Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjKcI9oT0l3ME2tOU45PyCP NUXkTYpSOjJ|M{[yOFY>
NCI-H23 NHvFe3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;BSY5td2eJSUWwQU02Njd|IF2= M1LMU|IzOzN4MkS2
NCI-H226 M{LVW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fvXYxw\0eLNUC9MVYvOjFiTR?= M1z6dlIzOzN4MkS2
NCI-H522 M4f3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXacI9oT0l3ME2tOk42QCCP NET0VHUzOjN|NkK0Oi=>
NCI-H483 NULwbHRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHXNnNkdG:pR1m1NF0uPi53NjDN NInhSJUzOjN|NkK0Oi=>
A549 NXfNOot5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjsc4dIUTVyPT22MlE2KE1? MWmyNlM{PjJ2Nh?=
DMS273 M2LvSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHricJZtd2eJSUWwQU03NjR|IF2= NXfzVFBrOjJ|M{[yOFY>
DMS114 MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX25[mo4dG:pR1m1NF0uPS57MjDN M{X0NFIzOzN4MkS2
LOXIMVI MnzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPrcI9oT0l3ME2tOk4zQSCP NInLPHUzOjN|NkK0Oi=>
OVCAR3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlW0cI9oT0l3ME2tOk44OSCP NIDH[YQzOjN|NkK0Oi=>
OVCAR4 NHzvZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vvNYxw\0eLNUC9MVUvPzZiTR?= MljjNlI{OzZ{NE[=
OVCAR5 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mle2cI9oT0l3ME2tOk4zPiCP NWfSNndwOjJ|M{[yOFY>
OVCAR8 NVTUUZkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\sc4dIUTVyPT21Mlc{KE1? MYOyNlM{PjJ2Nh?=
SKOV3 NV;GUWRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLsc4dIUTVyPT22MlUzKE1? NVH2RnZTOjJ|M{[yOFY>
RXF631L NVzQXZNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLEbmttd2eJSUWwQU03Njh6IF2= MUSyNlM{PjJ2Nh?=
ACHN MljUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG4SWdtd2eJSUWwQU03NjB5IF2= MYmyNlM{PjJ2Nh?=
St-4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT1cI9oT0l3ME2tOU42PiCP NYS5ZlVYOjJ|M{[yOFY>
MKN1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rVSYxw\0eLNUC9MVcvODhiTR?= MXmyNlM{PjJ2Nh?=
MKN7 MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzsc4dIUTVyPT22MlUxKE1? NWG2OpJ2OjJ|M{[yOFY>
MKN28 M3K4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGG1V3htd2eJSUWwQU02NjV{IF2= MnH3NlI{OzZ{NE[=
MKN45 NVTpdHlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjsc4dIUTVyPT22MlU2KE1? NVXQW|BoOjJ|M{[yOFY>
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DU145 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjCT4ltd2eJSUWwQU02Njh3IF2= NUHhdW91OjJ|M{[yOFY>
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HH NHLBZ4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3oSHJKSzVyPUGxNU4xQCCwTR?= NImzZXJUSU6JRWK=
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NCI-H1770 MmjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH2cmQyUUN3ME2xNlMvQDZibl2= MkjTV2FPT0WU
HuO9 M1nXNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvITWM2OD1{ME[uNFIhdk1? NYH0N5dvW0GQR1XS
HAL-01 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjRc|lrUUN3ME2yNFYvPzNibl2= M1v1fnNCVkeHUh?=
NOS-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP6Wm1KSzVyPUKxNU45OiCwTR?= NG\IUYZUSU6JRWK=
HGC-27 MoXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT1PI14UUN3ME2yNVIvPTdibl2= NX\2NnV{W0GQR1XS
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NCI-H1623 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnteYNNUUN3ME2zNFQvODhibl2= MmW3V2FPT0WU
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AN3-CA MkjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;aTWM2OD1|NECuN|chdk1? Mo\WV2FPT0WU
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CHL-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofsTWM2OD1|N{iuOlUhdk1? NV3jO5ZbW0GQR1XS
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MFE-280 Mn\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\HOlRJUUN3ME20NVgvOiCwTR?= MVLTRW5ITVJ?
HL-60 MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnxTWM2OD12MkWuO|Uhdk1? M{LSbnNCVkeHUh?=
GCIY MkPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXjW2dKSzVyPUSzN{45KG6P MoXHV2FPT0WU
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LXF-289 M1TLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnmTWM2OD12NEiuNlchdk1? NFSxZ2lUSU6JRWK=
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KU-19-19 Ml33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHzTWM2OD13MU[uNFchdk1? M1HIOnNCVkeHUh?=
A204 Mk\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3i5XGlEPTB;NUKyMlM{KG6P M2TCS3NCVkeHUh?=
LB1047-RCC Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;zSXdKSzVyPUWyNk46OyCwTR?= MY\TRW5ITVJ?
COLO-684 M{LiVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTV{Mz6xNUBvVQ>? M4LGWXNCVkeHUh?=
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NKM-1 M{XNcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGftb3hKSzVyPUW5N{4xQSCwTR?= MV;TRW5ITVJ?
T47D NEHFPVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTV7Nz61OkBvVQ>? NV6zTJh[W0GQR1XS
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IGROV-1 MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\v[XZKSzVyPU[zOE4{OSCwTR?= MXjTRW5ITVJ?
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NEC8 MkPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTZ3Mz61O{BvVQ>? MkH6V2FPT0WU
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EPCL-272H Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LUcmlEPTB;Nki3MlIyKG6P Mo\sV2FPT0WU
D-263MG MoHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnKT2pXUUN3ME23NVgvOSCwTR?= M{fTdnNCVkeHUh?=
MV-4-11 NXGyXoVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTd{ND6zNUBvVQ>? MYPTRW5ITVJ?
SK-NEP-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTd{NT65OEBvVQ>? NVLYTZZLW0GQR1XS
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L-363 NFnFSZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInnSXBKSzVyPUe5PE41OiCwTR?= NFXqelJUSU6JRWK=
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HSC-3 M1nJemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n6R2lEPTB;OEO5MlU1KG6P MnHBV2FPT0WU
H4 MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTh3MD64OUBvVQ>? NFXkVmRUSU6JRWK=
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OAW-42 MoTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\MO2poUUN3ME24O|IvOTlibl2= NFTWfHZUSU6JRWK=
MCF7 M2DrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[5U5VvUUN3ME24PVgvPTlibl2= MnHWV2FPT0WU
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NCI-H1563 NFTnRmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLvTWM2OD17MUWuPVkhdk1? MXfTRW5ITVJ?
OVCAR-5 NEOydlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoD1TWM2OD17NECuNVchdk1? MVzTRW5ITVJ?
HDLM-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTvWIpYUUN3ME25OFkvOiCwTR?= NWDnd4d5W0GQR1XS
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NCI-H292 NEjrNJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTl5ND6zNkBvVQ>? MljWV2FPT0WU
A101D MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj1cmlKSzVyPUm5NE4yQSCwTR?= M{TtZ3NCVkeHUh?=
NCI-H1648 NFXZdodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnSbJBKSzVyPUm5PE42OSCwTR?= MlHZV2FPT0WU
EKVX NYrDO5cxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWCwR2o1UUN3ME2xMlAyOjlizszN MX\TRW5ITVJ?
SW1710 MlHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTFwMESyN|Mh|ryP MmLQV2FPT0WU
WM-115 M37ZS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LacWlEPTB;MT6wOlY2PiEQvF2= M37pfnNCVkeHUh?=
CAL-54 NI\vZo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLN[25KSzVyPUGuNFcxQDFizszN NEO3WJlUSU6JRWK=
TGBC24TKB NVzJ[Vk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH3TWM2OD1zLkC4NFQ2KM7:TR?= MVLTRW5ITVJ?
NCI-H520 NXXUcopnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrOU|NKSzVyPUGuNFg6PjdizszN M3[3bXNCVkeHUh?=
D-423MG NInkZ|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHaS3VKSzVyPUGuNFk6PjJizszN MmjwV2FPT0WU
BFTC-905 MlHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHU[ZBKSzVyPUGuNVM1PDlizszN NH;MTJRUSU6JRWK=
HT MnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPvPGhKSzVyPUGuNVM1PzhizszN MXjTRW5ITVJ?
CTB-1 M3\RV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTFwMUSyPVMh|ryP MWTTRW5ITVJ?
Hs-578-T NVfFbnI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXIWY9KSzVyPUGuNVk2PjVizszN MXjTRW5ITVJ?
HuH-7 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PNfGlEPTB;MT6yNFk1QSEQvF2= NH7MXmdUSU6JRWK=
LB996-RCC MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHpTWM2OD1zLkKyNVc4KM7:TR?= NUT2VJk4W0GQR1XS
KYSE-270 M1jLZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrCW41KSzVyPUGuNlk4OzRizszN MnfzV2FPT0WU
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A498 MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjyTWM2OD1zLkOwOFc1KM7:TR?= M{fM[HNCVkeHUh?=
SK-MEL-1 NGjKO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXXTVhCUUN3ME2xMlMxPjd7IN88US=> NEXOOmdUSU6JRWK=
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Saos-2 NEntVGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTFwM{OyNFUh|ryP M4rLdnNCVkeHUh?=
A549 NHLxVYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPoUZhkUUN3ME2xMlM6QTdizszN NH\EUVJUSU6JRWK=
BFTC-909 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrZTWM2OD1zLkSzN|A2KM7:TR?= Mk\mV2FPT0WU
MDA-MB-415 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmmwTWM2OD1zLkS4OlkzKM7:TR?= NYTDbm9XW0GQR1XS
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A704 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPic3ZYUUN3ME2xMlUxPzh3IN88US=> M{Tl[3NCVkeHUh?=
PANC-03-27 Mk[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTFwNUG0NFgh|ryP MXHTRW5ITVJ?
SK-MEL-28 Mn7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPydVRlUUN3ME2xMlU3ODh3IN88US=> M4LVTHNCVkeHUh?=
Ramos-2G6-4C10 NHHtbo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHKWZdqUUN3ME2xMlYxPzR4IN88US=> NFfIVIpUSU6JRWK=
HuP-T4 NIryW4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;0TWM2OD1zLk[wO|c5KM7:TR?= M135ZnNCVkeHUh?=
VA-ES-BJ NXvx[IpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\RUWlEPTB;MT62NVI4KM7:TR?= M3PLV3NCVkeHUh?=
EFM-19 M4G2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PSUmlEPTB;MT62NVgyKM7:TR?= MnjQV2FPT0WU
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D-566MG M3fr[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DBbmlEPTB;MT62NlU{KM7:TR?= MVvTRW5ITVJ?
JVM-3 NEfI[FNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm5TWM2OD1zLk[0PFc2KM7:TR?= NUewfYJoW0GQR1XS
TK10 NXjHfpRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;rZ2lEPTB;MT62O|A5OyEQvF2= NETjOmhUSU6JRWK=
BT-20 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTFwNki5NFIh|ryP Mln0V2FPT0WU
EGI-1 NIn1cIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTFwOES3NFEh|ryP MVvTRW5ITVJ?
EW-16 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPnRVBRUUN3ME2xMlg2OTh{IN88US=> MWHTRW5ITVJ?
NCI-H2228 NXHmfFVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3QTWM2OD1zLki1NlA{KM7:TR?= NF[weHJUSU6JRWK=
BB49-HNC M1naNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPOeVNKSzVyPUGuPFg3QTJizszN M1PkfHNCVkeHUh?=
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NCI-H526 NHfhS|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO1NZNYUUN3ME2xMlkyOzlizszN MYLTRW5ITVJ?
ME-180 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\JTWM2OD1zLkmzOFc4KM7:TR?= NV;FeXRFW0GQR1XS
PFSK-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPOTWM2OD1zLkm0OFU5KM7:TR?= NHHhd4lUSU6JRWK=
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SK-MES-1 MoLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXSxc21qUUN3ME2yMlAyOzN{IN88US=> NYL6fI9{W0GQR1XS
SNB75 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTwTWM2OD1{LkCxOVQyKM7:TR?= Mo\xV2FPT0WU
LAMA-84 NH7ifFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M120bWlEPTB;Mj6wNlY5QSEQvF2= MmLjV2FPT0WU
CAL-39 MmT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTk[WxKSzVyPUKuNFMzQCEQvF2= NGXo[XpUSU6JRWK=
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NH-12 NGLSSFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnGcpZIUUN3ME2yMlA2PDJ2IN88US=> MW\TRW5ITVJ?
NCI-H1048 NXHsVod7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\sVGlEPTB;Mj6xNFUzKM7:TR?= NGjORmpUSU6JRWK=
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EW-13 MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfLWJYxUUN3ME23Mlg6QTd5IN88US=> NX3rNVVJW0GQR1XS
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RH-18 NU\lS3RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRThwM{WwOFYh|ryP MojaV2FPT0WU
SW48 NFvsXYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTXRYhFUUN3ME24MlU6PDV|IN88US=> M{LBfHNCVkeHUh?=
RD M1fFSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkKxTWM2OD16LkW5N|kyKM7:TR?= MY\TRW5ITVJ?
MS-1 NHS1VmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRThwNkGzPFch|ryP MXjTRW5ITVJ?
ES6 Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vVVWlEPTB;OD63N|EyQSEQvF2= M125cnNCVkeHUh?=
TE-12 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRThwN{e1NFUh|ryP Mnu3V2FPT0WU
DBTRG-05MG NGS3W2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRThwOUGyNVch|ryP MXjTRW5ITVJ?
KINGS-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojwTWM2OD16LkmyPVM5KM7:TR?= MmLCV2FPT0WU
HLE MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfkTWM2OD16LkmzO|g2KM7:TR?= MkLsV2FPT0WU
MHH-NB-11 NVzGRm1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnKTWM2OD17LkCxPFM6KM7:TR?= MkCxV2FPT0WU
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MN-60 NXPt[3kxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vhSWlEPTB;OT6yOFU1OiEQvF2= Mof6V2FPT0WU
SAS Mn;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjqdWVDUUN3ME25MlI2PThzIN88US=> MU\TRW5ITVJ?
NCI-H446 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX2TWM2OD17LkO2NUDPxE1? NG[5bVNUSU6JRWK=
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RXF393 NFL3ZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLTTWM2OD17LkS3NFAzKM7:TR?= NUXIXnB7W0GQR1XS
CGTH-W-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT0S|hCUUN3ME25MlQ6Ozh2IN88US=> Mn7rV2FPT0WU
RCM-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTlwNkO4NFEh|ryP MknLV2FPT0WU
SN12C NV7RN3lOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXwTld1UUN3ME25MlY2OzN6IN88US=> M1z1ZXNCVkeHUh?=
KLE M33PSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonDTWM2OD17LkewNFA6KM7:TR?= Mmr5V2FPT0WU
EFO-21 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLpTWM2OD17Lke3N|gzKM7:TR?= MWnTRW5ITVJ?
KYSE-70 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHr0d4RKSzVyPUmuPFgxOTFizszN Mlm2V2FPT0WU
D-247MG NV3EVWZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\SeFd5UUN3ME2xNE4xPTZ6IN88US=> NFrCeWlUSU6JRWK=
MPP-89 NWn1bYl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXwTWM2OD1zMD6wPVQ3KM7:TR?= MXPTRW5ITVJ?
RVH-421 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPY[4pKSzVyPUGwMlE2ODVizszN NGPvZYtUSU6JRWK=
NCI-H460 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmSwTWM2OD1zMD6yPFA3KM7:TR?= NF\TO3VUSU6JRWK=
NOMO-1 NUK5VGJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\3eWlEPTB;MUCuN|U{OiEQvF2= NVz1N4ZRW0GQR1XS
DEL NXXSUWM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHniPXlKSzVyPUGwMlM4QTRizszN NV3wfGlQW0GQR1XS
HT55 NID1PFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH60W2xKSzVyPUGwMlYzODVizszN NWrtRZZMW0GQR1XS
MC116 NEjMeI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fhVGlEPTB;MUCuOlY2PSEQvF2= NHfBSY1USU6JRWK=
BB30-HNC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHRdYZoUUN3ME2xNE43PjlizszN MoHIV2FPT0WU
DJM-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nyS2lEPTB;MUCuOlk1QSEQvF2= NGju[FRUSU6JRWK=
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U-118-MG M1jyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33iNWlEPTB;MUCuPVg6PiEQvF2= M4TMR3NCVkeHUh?=
MSTO-211H NFvMNo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXlTWM2OD1zMT6wO|E3KM7:TR?= M13YSXNCVkeHUh?=
SW837 NGe4XmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37sVmlEPTB;MUGuNFk1QSEQvF2= NHzSfpNUSU6JRWK=
HuCCT1 NG\4[lFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzyTWM2OD1zMT6xNlgyKM7:TR?= NGXUb2xUSU6JRWK=
RCC10RGB MljSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPx[|NOUUN3ME2xNU4yOzVizszN NGHweWhUSU6JRWK=
NMC-G1 M1\MVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzwbIlOUUN3ME2xNU4yPDl|IN88US=> NXnVVZBLW0GQR1XS
NCI-H650 NUH5Rld6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrwPVNKSzVyPUGxMlM4QTRizszN MkLsV2FPT0WU
HEC-1 M3LGW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTFzLkSzNlgh|ryP MVnTRW5ITVJ?
DU-4475 M1zwUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTFzLkezPVMh|ryP MkDXV2FPT0WU
DSH1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjDTWM2OD1zMT63OlA3KM7:TR?= MnLiV2FPT0WU
HCC1569 NXvUSHRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTFzLke2O|gh|ryP M2CxR3NCVkeHUh?=
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EW-11 M2LVZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTFzLkm0O|Qh|ryP MYfTRW5ITVJ?
LB2518-MEL M1\1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF{LkC1PUDPxE1? MYXTRW5ITVJ?
KALS-1 M176fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX70epNFUUN3ME2xNk45PTV|IN88US=> MWfTRW5ITVJ?
8505C MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGOyb2hKSzVyPUGyMlg5PSEQvF2= M1XrU3NCVkeHUh?=
SK-N-DZ M4DOOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi1cHU{UUN3ME2xN{4xPDV|IN88US=> NHHpZ45USU6JRWK=
CHP-134 MmHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1m4WmlEPTB;MUOuNVE2QCEQvF2= NULmWGRuW0GQR1XS
HCE-T NVKwTFBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HlU2lEPTB;MUOuNlM3PCEQvF2= NFfudWxUSU6JRWK=
LB-831-BLC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjEc2xWUUN3ME2xN{43OjR4IN88US=> NYL2NGJUW0GQR1XS
OVCAR-4 MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;menJKSzVyPUGzMlY2OjRizszN MluwV2FPT0WU
SW756 NUHydFk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDF[4tkUUN3ME2xN{44OjR4IN88US=> M4THSnNCVkeHUh?=
OCUB-M MoTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PtXGlEPTB;MUOuPFE2PiEQvF2= MWXTRW5ITVJ?
SW982 NYjDfYlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mor6TWM2OD1zMz64Nlc3KM7:TR?= MlnOV2FPT0WU
DB M4K5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGixfoxKSzVyPUGzMlg{QDRizszN MkDIV2FPT0WU
H-EMC-SS NWLXOoQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTF|LkmxN|kh|ryP NFHn[FhUSU6JRWK=
VMRC-RCZ M37MTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvGUVFKSzVyPUG0MlAxOTVizszN MojnV2FPT0WU
CAKI-1 MoTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHZTWM2OD1zND6wNVMzKM7:TR?= NVvmXY9HW0GQR1XS
GI-1 NYGwbFZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fqV2lEPTB;MUSuNFY2QCEQvF2= NV7iSnJNW0GQR1XS
Ca9-22 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT1clJKSzVyPUG0MlYxPTRizszN Mo[zV2FPT0WU
TE-5 NXjMXGR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn0[FNwUUN3ME2xOE44OjB6IN88US=> MnPiV2FPT0WU
EFO-27 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn1dnFtUUN3ME2xOE44PjJ{IN88US=> MXHTRW5ITVJ?
CAL-72 NIPnTohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rZUmlEPTB;MUSuO|c5OyEQvF2= NFjCW2JUSU6JRWK=
GP5d NILCb2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MornTWM2OD1zNT6wOFc1KM7:TR?= Mnq5V2FPT0WU
CAS-1 MmfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nOVGlEPTB;MUWuNFY3KM7:TR?= MUXTRW5ITVJ?
A2058 M4XY[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTF3LkW2N|gh|ryP NWLaeJRwW0GQR1XS
PANC-08-13 NV3Qflg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTF3Lk[4OVkh|ryP MkTqV2FPT0WU
Detroit562 M1P1SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLXeoRlUUN3ME2xOU46OTN7IN88US=> NGW5OXZUSU6JRWK=
PANC-10-05 MljlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnBTWM2OD1zNj6wPFIyKM7:TR?= NYTnNVRNW0GQR1XS
KOSC-2 NVHicmNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\Md2lEPTB;MU[uNVEzPSEQvF2= NWH5eIhOW0GQR1XS
GT3TKB NXu5RoZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DBPGlEPTB;MU[uNVk5OSEQvF2= NV[zeG4{W0GQR1XS
KM-H2 NEPSVZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjUXI1KSzVyPUG2MlM3PDZizszN MV3TRW5ITVJ?
LB771-HNC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULnOlBXUUN3ME2xOk41PDJ{IN88US=> M{D2dnNCVkeHUh?=
SF268 NYTS[Y9nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfxWpNKSzVyPUG2MlQ2OiEQvF2= MYjTRW5ITVJ?
OE19 NXjySmZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7jTWM2OD1zNj61NlQh|ryP NV\sWmZ2W0GQR1XS
MLMA NVjUZW1kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTF4LkW1O|Eh|ryP M{nXc3NCVkeHUh?=
MDA-MB-231 NX;jRZU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfnTG9VUUN3ME2xOk44OTN4IN88US=> NHrB[FFUSU6JRWK=
TGW NGD1WZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;tcJhzUUN3ME2xOk45OTB{IN88US=> MnqyV2FPT0WU
MDA-MB-453 MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P4WmlEPTB;MUeuNFAxOyEQvF2= M4j1PHNCVkeHUh?=
SNU-C2B NEXJcZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTuPGczUUN3ME2xO{4xOjN5IN88US=> MX;TRW5ITVJ?
A427 M1vwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF5LkKzN|Qh|ryP NX3tZ2lPW0GQR1XS
SK-MEL-2 Mk\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK2fJU4UUN3ME2xO{4{OjF|IN88US=> M2LYbXNCVkeHUh?=
KURAMOCHI NXuy[2x1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zY[GlEPTB;MUeuN|g6PyEQvF2= NFPLN2ZUSU6JRWK=
IST-MEL1 MlOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrPS2wxUUN3ME2xO{46OTh{IN88US=> NXLjT2JsW0GQR1XS
NCI-H1793 M1KyT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rycmlEPTB;MUiuNVU5OSEQvF2= NHjme|RUSU6JRWK=
HCC1395 NHnLW3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTnOppHUUN3ME2xPE42PjFzIN88US=> M3rCdHNCVkeHUh?=
NUGC-3 M17jT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XNb2lEPTB;MUiuOlU5PCEQvF2= MoPQV2FPT0WU
BB65-RCC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTF6Lk[2PUDPxE1? MUPTRW5ITVJ?
RMG-I M4DLcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jKWGlEPTB;MUiuO|M5OiEQvF2= MYHTRW5ITVJ?
LS-513 NHX0XIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTF6LkmyNlgh|ryP M121THNCVkeHUh?=
MFM-223 NUTWSIl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XEb2lEPTB;MUmuNFcyPiEQvF2= NVLkOIJVW0GQR1XS
NCI-H727 MoDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHJVmpKSzVyPUG5MlMzQTVizszN NGX0W4tUSU6JRWK=
KP-4 MkPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrkTWM2OD1zOT64OVMyKM7:TR?= MX\TRW5ITVJ?
NB13 NIfuSIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDITWM2OD1zOT64PFM6KM7:TR?= MX7TRW5ITVJ?
UACC-893 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\ifoRKSzVyPUG5Mlk4PTdizszN MoHrV2FPT0WU
HT-1197 NYLYPHlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPmOppKSzVyPUKwMlI6PThizszN NVfneGZsW0GQR1XS
NCI-H2029 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTJyLkOyOlYh|ryP NHTS[opUSU6JRWK=
GI-ME-N NVHpbZZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTJyLkOzO|Mh|ryP Mnq0V2FPT0WU
OVCAR-3 NWHj[WNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnkSoFKSzVyPUKwMlU5OjJizszN NFjUbppUSU6JRWK=
HD-MY-Z MknHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHQTWM2OD1{MT6zOlk3KM7:TR?= NYrndXZZW0GQR1XS
NTERA-S-cl-D1 MlfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HJdGlEPTB;MkGuOlczOiEQvF2= Mlf1V2FPT0WU
SCH NHvBcYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS1SpB1UUN3ME2yNk41QTZizszN NHX1PG5USU6JRWK=
KARPAS-299 M4T1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLVZmNKSzVyPUKzMlM5QDdizszN M3zDb3NCVkeHUh?=
NCI-H1650 M{jFU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrsTWM2OD1{Mz65NlQyKM7:TR?= NHKwUoRUSU6JRWK=
ACHN M4L1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;LXWlEPTB;MkSuOFY2PiEQvF2= MXXTRW5ITVJ?
M059J MonRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrpe2QxUUN3ME2yOE42PjN2IN88US=> NXvqVpZvW0GQR1XS
AM-38 MnrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PvTWlEPTB;MkWuOFgyKM7:TR?= MYjTRW5ITVJ?
KG-1 NEjhTmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2i3OWlEPTB;MkWuOVQ6PCEQvF2= NHfiN2RUSU6JRWK=
COLO-824 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLtT5dKSzVyPUK1MlU2QTlizszN NGqxelhUSU6JRWK=
NCI-H1155 M{nCUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrneJhnUUN3ME2yOU42QDR5IN88US=> MkDTV2FPT0WU
NCI-H441 MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTJ3Lke0OlUh|ryP NGrVb4JUSU6JRWK=
J-RT3-T3-5 MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXX3ZZFDUUN3ME2yOk4{ODJ5IN88US=> MYfTRW5ITVJ?
JEG-3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7yOW1KSzVyPUK2MlY5ODVizszN M4XGS3NCVkeHUh?=
RKO NVzmc|JMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Sw[GlEPTB;Mk[uO|Y{OiEQvF2= MnXoV2FPT0WU
CAL-85-1 MlW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\rTWM2OD1{Nz6yNVE5KM7:TR?= NHy3TFBUSU6JRWK=
CAL-120 MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTJ5Lk[5NVQh|ryP NITvR2xUSU6JRWK=
NCI-H2452 Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTJ5Lke3NVYh|ryP MkTkV2FPT0WU
NCI-H1395 M2jtS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTMelFrUUN3ME2yO{44QDN|IN88US=> MofNV2FPT0WU
KYSE-450 NFHOUFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG3VmRKSzVyPUK3Mlk5PjJizszN NXe2XI1OW0GQR1XS
S-117 MoXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJ7LkO4OVch|ryP Ml3JV2FPT0WU
SW13 M2jyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu2TWM2OD1{OT64OVE6KM7:TR?= Mlz0V2FPT0WU
ES3 NWnLUGY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTNyLkO3N|Mh|ryP MlGzV2FPT0WU
HCT-116 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzFPY9vUUN3ME2zNE42PTV2IN88US=> NFHoPFNUSU6JRWK=
NCI-H1693 MmDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7DTWM2OD1|MD61PVQzKM7:TR?= NYq4S5dRW0GQR1XS
VM-CUB-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37zemlEPTB;M{CuOlQyOyEQvF2= MnfIV2FPT0WU
NCI-H2170 MlW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7wZVM4UUN3ME2zNU42Pzh2IN88US=> MnSzV2FPT0WU
ALL-PO MnHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PYSmlEPTB;M{GuPFQzQCEQvF2= NYrQZXFvW0GQR1XS
NCI-H661 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTFTWM2OD1|Mj6wOlI{KM7:TR?= MUjTRW5ITVJ?
NCI-H2347 NFzKO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13Bb2lEPTB;M{KuOFg{PyEQvF2= M33uUXNCVkeHUh?=
FTC-133 M4m4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvjTWM2OD1|Mj63NFYh|ryP Mm\sV2FPT0WU
COLO-829 M1rRSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTN|LkO0Olch|ryP MnLOV2FPT0WU
GOTO NGf5XI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nKUmlEPTB;M{OuOVI2QCEQvF2= NYXLNGVDW0GQR1XS
YAPC NHvyN5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\GPIdMUUN3ME2zN{45OTV7IN88US=> MW\TRW5ITVJ?
LCLC-103H NH\YdHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\DOmlEPTB;M{SuNVYzPCEQvF2= MVHTRW5ITVJ?
SiHa MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPDWpJFUUN3ME2zOE4{QDF5IN88US=> MUfTRW5ITVJ?
LK-2 NHnme25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrqTWM2OD1|ND61O|A5KM7:TR?= NF\2W|lUSU6JRWK=
KP-N-YS NXzQUoJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXsV25KSzVyPUO0MlczODJizszN M3jnfnNCVkeHUh?=
NCI-SNU-1 NFi2O3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHSSodiUUN3ME2zOU4yPzlizszN M3z5WnNCVkeHUh?=
KNS-81-FD MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEexRoVKSzVyPUO1MlY3OyEQvF2= NHrKNHdUSU6JRWK=
SCC-9 NGfFTnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK4TWM2OD1|Nj63NVQ3KM7:TR?= M2rReHNCVkeHUh?=
SH-4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi5RYpKSzVyPUO2Mlc{KM7:TR?= Mo\2V2FPT0WU
HCC-1954 MnXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXieYZKSzVyPUO3MlI4OjlizszN MlyzV2FPT0WU
BALL-1 NGfxSXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfwUI1KSzVyPUO3MlU{OTZizszN M3noNHNCVkeHUh?=
BE-13 M3[3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrkcmFKSzVyPUO3MlcxOThizszN M{jDWHNCVkeHUh?=
COLO-678 M{PRdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkT3TWM2OD1|Nz65OFM4KM7:TR?= M{DQNXNCVkeHUh?=
SK-MEL-3 M3fQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TG[mlEPTB;M{iuNlM6PyEQvF2= MXjTRW5ITVJ?
OAW-28 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjyc|hNUUN3ME2zPE43OzlizszN MnvhV2FPT0WU
CAMA-1 NV;yflVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfaSlhKSzVyPUO4Mlk3QTFizszN NG\kOFRUSU6JRWK=
C2BBe1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn33TWM2OD1|OT64NVgh|ryP MXjTRW5ITVJ?
A3-KAW M{j0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3S2WmlEPTB;NECuN|Y3OSEQvF2= NYf1endJW0GQR1XS
SK-MEL-24 NIjINIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vNNmlEPTB;NECuOVk{OSEQvF2= MYfTRW5ITVJ?
KYSE-140 M4j0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DUTGlEPTB;NECuO|E3PSEQvF2= MYfTRW5ITVJ?
MOLT-16 NHPlb3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUH3R3RmUUN3ME20NU4yPTN4IN88US=> NGW4cWxUSU6JRWK=
CFPAC-1 M3rXWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHHVopIUUN3ME20Nk42OjFzIN88US=> Mn3FV2FPT0WU
NB14 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFq4e4VKSzVyPUSyMlcxOjdizszN NH3mS4FUSU6JRWK=
COLO-792 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXMOFhKSzVyPUSyMlg6PjFizszN MWjTRW5ITVJ?
RH-1 M{Txd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXryfGdNUUN3ME20N{41QDN4IN88US=> NXLKd3dYW0GQR1XS
NCI-H522 NGiwNHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{i0NGlEPTB;NESuN|U3QCEQvF2= M3m3ZXNCVkeHUh?=
Ca-Ski NHHMTlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHiVHJKSzVyPUS0MlgyOTRizszN M3u2UnNCVkeHUh?=
KGN MnvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fZfmlEPTB;NEiuN|A3OyEQvF2= MWrTRW5ITVJ?
UACC-62 M2Hmdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILDWZpKSzVyPUS4MlQxPzJizszN NG\BTIZUSU6JRWK=
NCI-H358 NXTtWXVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTR7LkOwNVgh|ryP NV3uXolrW0GQR1XS
LS-411N MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHRZnlZUUN3ME20PU4{OTF6IN88US=> M3L4TXNCVkeHUh?=
IST-MES1 NVP1SVh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTR7LkW2NlUh|ryP NXG2ZmhFW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-FoxO3a / FoxO3a / PUMA; 

PubMed: 29137323     


HCT116 cells were treated with 4μmol/L NVP-BKM120 or 4μmol/L Pictilisib for 24 hours. Indicated protein levels were analyzed by Western blotting.

p-S6RP / S6RP; 

PubMed: 30042442     


Western blot analysis of proteins as indicated in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. Vinculin was used as a loading control. 

p-4EBP1 / 4EBP1; 

PubMed: 25857298     


Cells were treated with 0.5 μM GDC-0941 for the indicated time course and then collected for Western blot analysis of p-4EBP1. 

p-LRP6 / LRP6; 

PubMed: 25857298     


MDAMB-231, HCC1937 and MCF7 cells were treated with 0.5 µM GDC-0941 for 1 hr, and cell lysates were used for immunoblot analyses.

p-PAK / PAK1 / p-CRAF / RAF / p-MEK / MEK / p-ERK / ERK; 

PubMed: 24327733     


Cells were treated with 1 μM GDC-0941 for the indicated times, and lysates were probed with the indicated antibodies. Independent experiments were performed at least three times, and a representative result is shown.

29137323 30042442 25857298 24327733
Immunofluorescence
p65; 

PubMed: 30042442     


Representative images of immunofluorescent staining of p65 cellular localization in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. 4T1 cells were cultured alone or co-cultured with RAW264.7 macrophages. Representative images of three independent experiments are shown. 

beta-catenin; 

PubMed: 25857298     


Cells were seeded on coverslips the day before the experiment and treated with 0.5 µM GDC-0941 for 18 hr. The immunofluorescence (IF) of beta-catenin is indicated as red fluorescence, and double staining with DAPI is blue. Magnification: 400 X for the left three panels. The right panel shows enlarged images from the white squares.

30042442 25857298
Growth inhibition assay
Cell viability; 

PubMed: 27117832     


The viability of the indicated cells treated with increasing concentrations of GDC-0941 (ranging from 70nM to 20 μM) for 72 hours, determined by CellTiter Glo Viability assay. The IC50 concentrations were calculated using GraphPad Prism program. The assay was performed in triplicate, and the error bars represent standard deviations.

27117832
体内研究 在微粒体中,GDC-0941仅有有限的代谢,其口服生物利用度为78%[5]。GDC-0941 每天按 75 mg/kg剂量处理携带人U87MG 恶性胶质移植瘤的雌性NCr无胸腺小鼠,显著抑制生长,肿瘤生长抑制率为 83%。[1]GDC-0941 每天按 150 mg/kg剂量口服处理携带HER2扩增的抗Trastuzumab的MDA-MB-361.1移植瘤 的小鼠,抑制肿瘤生长,且显著延迟肿瘤衰退,与肿瘤中强诱导型凋亡相关。[2] GDC-0941 每天按75 mg/kg剂量处理携带自发性B细胞滤泡性淋巴瘤的PTEN+/-LKB1+/hypo小鼠,持续2周,诱导肿瘤体积下降~40%,伴随着AKT, S6K 和SGK(血清和糖皮质激素蛋白激酶)蛋白激酶的磷酸化被切除。GDC-0941抑制肿瘤细胞增殖,诱导凋亡和抑制中心母细胞数。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

闪烁接近检测:

使用p85α调节亚基,使重组人PI3Kα, PI3Kβ, 和PI3Kδ在 Sf9 杆状病毒系统中共表达,在谷胱甘肽-琼脂糖凝胶上进行亲和层析而纯化GST-融合蛋白。重组人 PI3Kγ表达作为单体 GST融合,也想上述相似方法纯化。GDC-0941 溶于DMSO,加到含200 μg硅酸钇(Ysi) 聚赖氨酸SPA 磁珠, 4 mM MgCl2, 1 mM 二硫苏糖醇 (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, 和4% (v/v) DMSO的20 mM Tris-HCl (pH 7.5)上,总体积为 50 μL。PI3Kα (5 ng), PI3Kβ(5 ng), PI3Kδ(5 ng), 或PI3Kγ(5 ng)的重组GST-融合 ,加到实验混合物中,开始激酶反应。在室温下温育1小时后, 加入150 μL PBS终止反应。混合物在2000 rpm 转速下离心2分钟,然后使用Wallac Microbeta计数器读数。在 MDL Assay Explorer系统中使用S型,剂量-反应曲线,计算进行至少2次独立重复实验,取平均值,作为IC50值。
细胞实验:

[2]

- 合并
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, 和MKN-7
  • Concentrations: 溶于DMSO,终浓度为~10 μM
  • Incubation Time: 48,和72小时
  • Method:

    使用不同浓度 GDC-0941处理细胞48,和 72小时。通过CellTiter-Glo Luminescent细胞活性检测实验测定细胞增殖/活力。通过Western Blot分析pAKT (Ser473), cleaved caspase-3, 和cleaved PARP通过 Caspase-Glo 3/7实验和细胞死亡检测 ELISAplus 实验分别测定caspase 3/7活性, 和凋亡。


    (Only for Reference)
动物实验:

[2]

- 合并
  • Animal Models: 移植MDA-MB-361.1细胞的NCR裸鼠, 皮下移植BT474-M1 细胞的SCID, C.B-17/IcrHsd-Prkdcscid 小鼠
  • Formulation: 溶于10% DMSO, 5% Tween-20, 85% 水
  • Dosages: ~150 mg/kg/day
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 513.64
化学式

C23H27N7O3S2

CAS号 957054-30-7
储存条件 粉状
溶于溶剂
别名 RG7321

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02092831 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. April 2014 Phase 1
NCT01740336 Completed Drug: GDC-0941|Drug: Placebo|Drug: Paclitaxel Breast Cancer Genentech Inc. February 6 2013 Phase 2
NCT01474668 Completed Drug: GDC-0941 Healthy Volunteer Genentech Inc. October 2011 Phase 1
NCT01240226 Completed Drug: GDC-0941|Drug: ketoconazole Healthy Volunteer Genentech Inc. November 2010 Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

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  • * 必填项

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

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