Pictilisib (GDC-0941)

For research use only. Not for use in humans.

目录号:S1065 别名: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) 是一种有效的PI3Kα/δ抑制剂,在无细胞试验中IC50为 3 nM,对p110β (11倍)和p110γ (25倍)具有适度的选择性。Pictilisib (GDC-0941) 可诱导自噬和凋亡。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1972.48 现货
RMB 986.88 现货
RMB 1390.74 现货
RMB 3026.17 现货
RMB 7926.11 现货
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客户使用Selleck生产的Pictilisib (GDC-0941)发表文献307篇:

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Pictilisib (GDC-0941) 是一种有效的PI3Kα/δ抑制剂,在无细胞试验中IC50为 3 nM,对p110β (11倍)和p110γ (25倍)具有适度的选择性。Pictilisib (GDC-0941) 可诱导自噬和凋亡。Phase 2。
靶点
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
体外研究

GDC-0941也等效作用于PI3Kα和 PI3Kδ和PI3Kα突变型E545-K和H1047-R,也选择性作用于PI3Kβ(10倍)和 PI3Kγ(25倍), 选择性更高地作用于PI3K II, III, 和IV类成员,包括, C2β, Vps34, DNA-PK和mTOR。GDC-0941 作用于U87MG, PC3, 和 MDA-MB-361 细胞,有效抑制Akt磷酸化,IC50分别为46 nM, 37 nM,和 28 nM。GDC-0941抑制U87MG, A2780, PC3, 和MDA-MB-361细胞增殖,IC50分别为 0.95 μM, 0.14 μM, 0.28 μM, 和0.72 μM。[1]GDC-0941处理,有效抑制对Trastuzumab敏感和不敏感的HER2扩增细胞增殖,IC50为149-944 nM,与 Trastuzumab敏感性无关。GDC-0941抑制含PIK3CA突变的HER2扩增的细胞增殖,IC50<500 nM, 且有效抑制抗trastuzumab 的HER2 扩增乳腺癌细胞增殖和活力。[2]GDC-0941 显著抑制HCT116, DLD1和 HT29细胞生长,GI50分别为1081 nM, 1070 nM 和157 nM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 NYXBO2hVU2mwYYPlJGF{e2G7 MWixJIg> NYLJUFFMTE2VTx?= MljmTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCmZXz0ZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZUB4cXSqIFnDOVAhd2ZiMD6wNFMh|ryP M1THWVE5PzV2NkW0
Sf9 NYjY[pRUU2mwYYPlJGF{e2G7 NUjiU4FWOSCq NUTN[FhPTE2VTx?= NGH4dZBKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEhUDFyNEetVkBufXSjboSg[ZhxemW|c3XkJIlvKFOoOTDj[YxteyClb3X4dJJme3OrbnegdFg2[WyyaHGge4l1cCCLQ{WwJI9nKDBwMECzJO69VQ>? MU[xPFc2PDZ3NB?=
Sf9 MoLrT4lv[XOnIFHzd4F6 NXnKd5lSOSCq NF;NPZFFVVOR M{LiWWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYnX0ZUBGPTR3LVugcZV1[W62IHX4dJJme3OnZDDpckBU\jliY3XscJMh[2:neIDy[ZN{cW6pIIC4OYFteGijIIfpeIghUUN3MDDv[kAxNjByMzFOwG0> M4LTeVE5PzV2NkW0
Sf9 NYL0[pBtU2mwYYPlJGF{e2G7 MnfLNUBp NGTjdYxFVVOR NGXDXopKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIEhf2m2aDDJR|UxKG:oIECuNFM{KM7:TR?= MlnkNVg4PTR4NUS=
Sf9 M1jCWmtqdmG|ZTDBd5NigQ>? MlLqNUBp NVjYfFFGTE2VTx?= M2X3TmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYXzwbIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIE> NFXTVHIyQDd3NE[1OC=>
MDA-MB-361 MmrZSpVv[3Srb36gRZN{[Xl? MkHKNkBp Mn3wSG1UVw>? MYrJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlAzQCEQvF2= NGKyblAyQDd3NE[1OC=>
PC3 MonnSpVv[3Srb36gRZN{[Xl? NHrW[m4zKGh? MVPEUXNQ MofmTY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDQWGVPNW63bHygbJVu[W5iUFOzJINmdGy|IIfpeIghUUN3MDDv[kAxNjB|NzFOwG0> NVTLOosxOTh5NUS2OVQ>
U87MG M4fIeGZ2dmO2aX;uJGF{e2G7 M3\ad|IhcA>? M1rWZ2ROW09? NULrNXhvUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBRXEWQLX71cIwhcHWvYX6gWVg4VUdiY3XscJMhf2m2aDDJR|UxKG:oIECuNFQ3KM7:TR?= NITZVGYyQDd3NE[1OC=>
MDA-MB-361 MoG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Puelk3KGh? MWHEUXNQ NXHtWZYzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC55MjFOwG0> NUO2NYRIOTh5NUS2OVQ>
A2780 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rZO|k3KGh? M4fZdGROW09? NYfEdpoxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{B4cXSqIGDJT|NESSCjbnSgVHRGViCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4yPCEQvF2= NVjDN3k1OTh5NUS2OVQ>
PC3 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXmPVYhcA>? M4LnU2ROW09? MUjJR|UxRTBwMkig{txO NUDyT2h5OTh5NUS2OVQ>
U87MG NV\uZlZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEf3VW06PiCq MU\EUXNQ MmT6TWM2OD1yLkm1JO69VQ>? NITJd2YyQDd3NE[1OC=>
Sf9 MofBT4lv[XOnIFHzd4F6 NVqycpNMOzBibXnu MmPtSG1UVw>? M1TJSWlvcGmkaYTpc44hd2ZiaIXtZY4hWEl|S3fhcY1iKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDhcY92dnRib3[gRXRRKGOxboP1cYVlKHerdHigTWM2OCCxZjCwMlA1OiEQvF2= NH\aSWEzOjV2OEO0Ni=>
RAW 264.7 NYS2SYlxU2mwYYPlJGF{e2G7 MnLhPVAhdWmw NYPROoVNTE2VTx?= NXrVXGVOUW6qaXLpeIlwdiCxZjDoeY1idiCSSUPL[4FudWFiZYjwdoV{e2WmIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiQVvUJJBpd3OyaH;yfYxifGmxbjD3bZRpKEmFNUCgc4YhOC5{OUig{txO MnvuNlI2PDh|NEK=
Sf9 MV3LbY5ie2ViQYPzZZk> NUO3V5NXOSCq MmjPTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4JmfGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKFOIOTDj[YxteyC5aYToJGlEPTBib3[gNE4xOTdizszN NEeyXXozOzV2ME[0OS=>
Sf9 MnfyT4lv[XOnIFHzd4F6 NVHXXXV5OSCq MVrJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPL[IVtfGFiZYjwdoV{e2Wm NEfJTpczOzV2ME[0OS=>
Sf9 NHfmVmVMcW6jc3WgRZN{[Xl? MX:xJIg> M3WzTGlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2to[W2vYTDlfJBz\XO|ZXS= MonNNlM2PDB4NEW=
Sf9 NGTwZ4VMcW6jc3WgRZN{[Xl? MmLFNUBp MXfJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPLZYxxcGFiZYjwdoV{e2Wm MXSyN|U1ODZ2NR?=
SKOV3 MVLLbY5ie2ViQYPzZZk> M4DBUVEh|ryP M2LB[VEhcA>? MmDnSG1UVw>? MnzxTY5pcWKrdHnvckBw\iCSSUPLZYxxcGFiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdg>? M4DrWlI{OzZyM{S4
MCF7 M4r6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlGxNUDPxE1? NEnWOHI6PiCq NVmyXGJjTE2VTx?= NGqz[pBIUTVyPUCuNFcxOiEQvF2= NVu2[21iOjN|NkCzOFg>
SKOV3 NVzxcJEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPBPW8yKM7:TR?= M3\zU|k3KGh? MYfEUXNQ MYjHTVUxRTBwMUS3OkDPxE1? M1XwTlI{OzZyM{S4
PC3 NWm4PWU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPvWYk4OiCq NXrFO2h5TE2VTx?= MnTKTWM2OD1yLkK4JO69VQ>? M4jOXFIyQThzN{G0
MCF7.1 NUH2Oo1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf3O|IhcA>? MlLqSG1UVw>? NHfuXYFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlcvOSClZXzsd{BmgHC{ZYPzbY5oKEiHUkKg[4Vv\SC5aYToJGlEPTBib3[gNE4zQCEQvF2= M3TYOVIyQThzN{G0
MCF7-neo/Her2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrEO204OiCq NEPYfGJFVVOR MoTYTWM2OD1yLkK5JO69VQ>? M4TzWlI{PjZ{OUCz
MCF7-neo/Her2 NX;lR4xMU2mwYYPlJGF{e2G7 M{DWZ2lvcGmkaYTpc44hd2ZiUFmzT4FteGijIHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCDS2SgdIhwe3Cqb4L5cIF1cW:wIHH0JHM1PzNid3n0bEBKSzVyIH;mJFAvODB5IN88US=> M4TQcFI{PjZ{OUCz
PC3 M{TSNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvZeGhsPzJiaB?= MWnEUXNQ M{fNcGVEPTB;MD6zOEDPxE1? M4TMXlIyQTh3NkO5
MCF7.1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\idWVUPzJiaB?= M2DSRmROW09? MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCHQ{WwJI9nKDBwM{mg{txO Mk\UNlE6QDV4M{m=
PC3 MnXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVy3NkBp NG\h[nVFVVOR NYXFcox3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOg[IVncWOrZX70JIlvKFCWRV6ge4l1cCCLQ{WwJI9nKDBwM{mg{txO NIW2ZVYzODB3ME[2PS=>
MCF7.1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi1W3luPzJiaB?= MUnEUXNQ MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCLQ{WwJI9nKDBwM{Sg{txO NFnJe5kzODB3ME[2PS=>
MCF7.1 Mki3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XR[lczKGh? NF\CSpJGSzVyPUCuO|Ih|ryP NV33dVJ2OjB|NE[2OVY>
NCI-H1975 MYTDfZRwfG:6aXOgRZN{[Xl? NEK0e5I4OiCq NUHwdoJNUUN3ME2wMlI4KM7:TR?= M1nYcFI{ODV7NUS1
H460 NX6zN3RoS3m2b4TvfIlkKEG|c3H5 MVi3NkBp NFTY[XVKSzVyPUCuPFch|ryP MV:yN|A2QTV2NR?=
HT-29 M3vOd2N6fG:2b4jpZ{BCe3OjeR?= MXu3NkBp NF;pO5FKSzVyPUCuOlYh|ryP NVXxW3A2OjNyNUm1OFU>
HepG2 Mnv2R5l1d3SxeHnjJGF{e2G7 NFn5bXE4OiCq MkLSTWM2OD1zIN88US=> MYKyN|A2QTV2NR?=
SGC7901 NXnqWplNS3m2b4TvfIlkKEG|c3H5 M3\HV|czKGh? M3u2W2lEPTB;MT64JO69VQ>? M1\NcFI{ODV7NUS1
NCI-H226 MWnDfZRwfG:6aXOgRZN{[Xl? MmHWO|IhcA>? M2q4cmlEPTB;Mj65JO69VQ>? NIm0bo0zOzB3OUW0OS=>
A549 MkWxR5l1d3SxeHnjJGF{e2G7 M1XkNVczKGh? Mkj4TWM2OD14Lkmg{txO MkLlNlMxPTl3NEW=
U87MG MXXDfZRwfG:6aXOgRZN{[Xl? NYfXU2dpPzJiaB?= M{frVGlEPTB;Nz63O{DPxE1? NH3VcYYzOzB3OUW0OS=>
HBC4 NFPB[lFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLTTVZtd2eJSUWwQU03NjB|IF2= MlrMNlI{OzZ{NE[=
BSY1 M4qyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDpOWo2dG:pR1m1NF0uPi57MDDN M{XBRVIzOzN4MkS2
HBC5 NGL1NFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzUbpJxdG:pR1m1NF0uPi54MDDN M3XPbVIzOzN4MkS2
MCF7 NVqwcZRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTQXGttd2eJSUWwQU04NjN|IF2= NUfrfFJ1OjJ|M{[yOFY>
MDA-MB-231 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPpcI9oT0l3ME2tOU41PiCP NW\NOXdLOjJ|M{[yOFY>
U251 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTXVnhldG:pR1m1NF0uPS53MDDN MUKyNlM{PjJ2Nh?=
SF268 NVTWdHVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\UcI9oT0l3ME2tOU4{QSCP MUeyNlM{PjJ2Nh?=
SF295 NV;aN|A{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e3Ooxw\0eLNUC9MVYvOzdiTR?= M175XlIzOzN4MkS2
SF539 M2K1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDkT|FPdG:pR1m1NF0uPi53MDDN MorhNlI{OzZ{NE[=
SNB75 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTFcI9oT0l3ME2tO{4yOCCP MmnENlI{OzZ{NE[=
SNB78 MoLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHsc4dIUTVyPT22MlUzKE1? Mo\zNlI{OzZ{NE[=
HCC2998 M1Hx[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLscI9oT0l3ME2tOk4zQSCP NILQdnIzOjN|NkK0Oi=>
KM12 NEHBNWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\WNoxw\0eLNUC9MVUvPzZiTR?= MlXaNlI{OzZ{NE[=
HT-29 NUHnWGZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrsc4dIUTVyPT22MlMxKE1? NXfkSG1{OjJ|M{[yOFY>
HCT15 Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nNdYxw\0eLNUC9MVYvOTJiTR?= MVeyNlM{PjJ2Nh?=
HCT116 M{WzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfJcI9oT0l3ME2tOU45PyCP M4n0S|IzOzN4MkS2
NCI-H23 M{njSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLzcI9oT0l3ME2tOU44OyCP M2TXSVIzOzN4MkS2
NCI-H226 NFznTpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\sc4dIUTVyPT22MlIyKE1? M4TVblIzOzN4MkS2
NCI-H522 M3Ln[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXVcI9oT0l3ME2tOk42QCCP NYnQVXJYOjJ|M{[yOFY>
NCI-H483 NHXLRVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjsc4dIUTVyPT22MlU3KE1? MX[yNlM{PjJ2Nh?=
A549 NVjFcHJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDtVllydG:pR1m1NF0uPi5zNTDN NX;4fIN3OjJ|M{[yOFY>
DMS273 NHnsd2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnsc4dIUTVyPT22MlQ{KE1? MX:yNlM{PjJ2Nh?=
DMS114 M2fCWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDTd4ZRdG:pR1m1NF0uPS57MjDN MXeyNlM{PjJ2Nh?=
LOXIMVI MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHSSGNtd2eJSUWwQU03NjJ7IF2= MnrHNlI{OzZ{NE[=
OVCAR3 MnfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\sc4dIUTVyPT22MlcyKE1? M133dlIzOzN4MkS2
OVCAR4 MnPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELVcW1td2eJSUWwQU02Njd4IF2= NWXmNnBLOjJ|M{[yOFY>
OVCAR5 MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{O2W4xw\0eLNUC9MVYvOjZiTR?= NU\Cc3pKOjJ|M{[yOFY>
OVCAR8 NFXScohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPCbnN6dG:pR1m1NF0uPS55MzDN MXWyNlM{PjJ2Nh?=
SKOV3 NGrqSYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HWZ4xw\0eLNUC9MVYvPTJiTR?= MXSyNlM{PjJ2Nh?=
RXF631L MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L1fIxw\0eLNUC9MVYvQDhiTR?= M4\k[VIzOzN4MkS2
ACHN NXnaOolUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;yNm1VdG:pR1m1NF0uPi5yNzDN M{P2flIzOzN4MkS2
St-4 NXG0c29rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPsc4dIUTVyPT21MlU3KE1? M1TZWFIzOzN4MkS2
MKN1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPGUGpHdG:pR1m1NF0uPy5yODDN NYrITocxOjJ|M{[yOFY>
MKN7 M{HITWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLscI9oT0l3ME2tOk42OCCP Ml3CNlI{OzZ{NE[=
MKN28 NITqNXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF6y[|htd2eJSUWwQU02NjV{IF2= NVvtRVVyOjJ|M{[yOFY>
MKN45 NWf4bYF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml36cI9oT0l3ME2tOk42PSCP M{\rfFIzOzN4MkS2
MKN74 NGnOR4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DQRYxw\0eLNUC9MVYvODJiTR?= MV:yNlM{PjJ2Nh?=
DU145 NETsOW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEToR|Vtd2eJSUWwQU02Njh3IF2= MU[yNlM{PjJ2Nh?=
PC3 NULqSGZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7sc4dIUTVyPT22MlY3KE1? MW[yNlM{PjJ2Nh?=
ES5 Mk[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTVyLkKxJI5O MYXTRW5ITVJ?
HH Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfBTWM2OD1zMUGuNFghdk1? M4[4WXNCVkeHUh?=
MHH-PREB-1 MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M12ze2lEPTB;MUG0MlMhdk1? NX:zU2x7W0GQR1XS
NCI-H1770 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LKc2lEPTB;MUKzMlg3KG6P M1znXXNCVkeHUh?=
HuO9 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\CTWM2OD1{ME[uNFIhdk1? MXTTRW5ITVJ?
HAL-01 M1zibmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fydWlEPTB;MkC2Mlc{KG6P MofXV2FPT0WU
NOS-1 NYWyU3pET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLkTWM2OD1{MUGuPFIhdk1? NUmyRXB[W0GQR1XS
HGC-27 Mn\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTRV4ZKSzVyPUKxNk42PyCwTR?= MlHKV2FPT0WU
NB69 NEL4TGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3yzTmlEPTB;MkS1MlI4KG6P MnL6V2FPT0WU
RS4-11 NHvITplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDLN3hKSzVyPUK2NU44PiCwTR?= M133[HNCVkeHUh?=
DOK NGWxfYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\Je5Z1UUN3ME2zNFEvPyCwTR?= NV3SSWhEW0GQR1XS
LB2241-RCC M1TnTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTNyMz64OEBvVQ>? M{XXXnNCVkeHUh?=
NCI-H1623 NEPnN5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLaRZpKSzVyPUOwOE4xQCCwTR?= MVnTRW5ITVJ?
YH-13 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTNyND6zNkBvVQ>? M1P4VnNCVkeHUh?=
BPH-1 MorQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3rTWM2OD1|MUSgcm0> NIDUVlFUSU6JRWK=
AN3-CA M4[zdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn72TWM2OD1|NECuN|chdk1? NHvHemZUSU6JRWK=
ES7 NXjHO|JET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XMZ2lEPTB;M{SxMlk6KG6P MWnTRW5ITVJ?
MDA-MB-175-VII NXLyfWp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTN3Mj65NkBvVQ>? NYDZenJyW0GQR1XS
GAMG NF3Od41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLzRoJ7UUN3ME2zO|AvQDVibl2= NXXJZ4J4W0GQR1XS
CHL-1 NHi1[VhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFy1VGJKSzVyPUO3PE43PSCwTR?= MWPTRW5ITVJ?
NB7 M{PWN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTN6OT64N{BvVQ>? NYrUOVdKW0GQR1XS
MFE-280 NEfabXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XzVGlEPTB;NEG4MlIhdk1? M1H2S3NCVkeHUh?=
HL-60 M4XteGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTR{NT63OUBvVQ>? NGDtcXVUSU6JRWK=
GCIY M2q2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjL[4xYUUN3ME20N|MvQCCwTR?= MYXTRW5ITVJ?
MDA-MB-361 MlHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLKVHN5UUN3ME20N|kvOTNibl2= MWPTRW5ITVJ?
LXF-289 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LNeWlEPTB;NES4MlI4KG6P NX[zRXo6W0GQR1XS
NBsusSR MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTR6OD64OUBvVQ>? M1;2S3NCVkeHUh?=
KU-19-19 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnObHFxUUN3ME21NVYvODdibl2= M{HIR3NCVkeHUh?=
A204 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjYTWM2OD13MkKuN|Mhdk1? M3q5dHNCVkeHUh?=
LB1047-RCC M3ftUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnDNY5KSzVyPUWyNk46OyCwTR?= MmDlV2FPT0WU
COLO-684 NV3N[WRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LmUGlEPTB;NUKzMlEyKG6P NEnNZWxUSU6JRWK=
PA-1 M2Hjc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu5VZZFUUN3ME21N|IvPDFibl2= NFzNbo5USU6JRWK=
MG-63 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTV2MT6xNUBvVQ>? NHLGbXJUSU6JRWK=
BHT-101 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV25NVM2UUN3ME21OFQvQTRibl2= MmfvV2FPT0WU
NKM-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rOdGlEPTB;NUmzMlA6KG6P NXrqSmtyW0GQR1XS
T47D M{jWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zhdmlEPTB;NUm3MlU3KG6P NV;JO2VRW0GQR1XS
MOLT-4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPiTFE{UUN3ME22NlMvPjJibl2= NFi2dllUSU6JRWK=
IGROV-1 MlnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3oWo1GUUN3ME22N|QvOzFibl2= M4r5XnNCVkeHUh?=
ES4 MoTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzxTWM2OD14M{muOVQhdk1? M2[2dHNCVkeHUh?=
HuO-3N1 M1TmdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mni5TWM2OD14NEKuN|ghdk1? MmnUV2FPT0WU
NEC8 MkWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTZ3Mz61O{BvVQ>? NVPQNoJ{W0GQR1XS
HO-1-N-1 NYPKRol5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX72dFd[UUN3ME22OVkvOTdibl2= MVrTRW5ITVJ?
EPCL-272H NIDhS5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTZ6Nz6yNUBvVQ>? NG\ENmtUSU6JRWK=
D-263MG M3TXXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf2XXhKSzVyPUexPE4yKG6P M3vzXHNCVkeHUh?=
MV-4-11 NEPyfXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\WXWlEPTB;N{K0MlMyKG6P NY[4cVk1W0GQR1XS
SK-NEP-1 M4PIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDnRVRKSzVyPUeyOU46PCCwTR?= M3P3fnNCVkeHUh?=
SW872 MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NED3OlJKSzVyPUeyO{45QSCwTR?= M1XNXHNCVkeHUh?=
P30-OHK MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTd|MD63NUBvVQ>? NHO5ZZlUSU6JRWK=
OMC-1 NX;lR4tYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH1TWM2OD15NUGuNFkhdk1? NYG5UXlKW0GQR1XS
LoVo NVjLZYtJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7EXVVOUUN3ME23O|cvQSCwTR?= NIPEXJNUSU6JRWK=
LNCaP-Clone-FGC NUTZVlI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGmxXVFKSzVyPUe5Ok4{PCCwTR?= MlXwV2FPT0WU
L-363 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPueHBKSzVyPUe5PE41OiCwTR?= MUXTRW5ITVJ?
ES8 M2e2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvpWVM2UUN3ME24NVAvPTJibl2= M2j3WXNCVkeHUh?=
697 NGnlU4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jvbmlEPTB;OEOxMlU2KG6P NUDpeYFHW0GQR1XS
HSC-3 NEDZOFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljWTWM2OD16M{muOVQhdk1? NIXFXodUSU6JRWK=
H4 Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LzWWlEPTB;OEWwMlg2KG6P MmH2V2FPT0WU
QIMR-WIL MmfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTh4NT6yJI5O MUTTRW5ITVJ?
OAW-42 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\ZR3JJUUN3ME24O|IvOTlibl2= NEDFc2hUSU6JRWK=
MCF7 M2TpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofiTWM2OD16OUiuOVkhdk1? NXT3eFlJW0GQR1XS
SCC-25 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj2T4RKSzVyPUmxOE4yQSCwTR?= NEXLXmVUSU6JRWK=
NCI-H1563 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTlzNT65PUBvVQ>? NXHRXo1xW0GQR1XS
OVCAR-5 NU\0XohQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DRW2lEPTB;OUSwMlE4KG6P MnLFV2FPT0WU
HDLM-2 M13VPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHiweJhKSzVyPUm0PU4zKG6P NFXMPYlUSU6JRWK=
NB5 Mn7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPIUnRKSzVyPUm1Ok43KG6P MXfTRW5ITVJ?
NCI-H292 M1TBeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTl5ND6zNkBvVQ>? NW[zRm9wW0GQR1XS
A101D NVXpNVJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTl7MD6xPUBvVQ>? M4GyOHNCVkeHUh?=
NCI-H1648 NXTaOJloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTl7OD61NUBvVQ>? NIjXSpRUSU6JRWK=
EKVX NFjRU2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nVU2lEPTB;MT6wNVI6KM7:TR?= MWXTRW5ITVJ?
SW1710 NXvKV5lYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\xRZZKSzVyPUGuNFQzOzNizszN MV\TRW5ITVJ?
WM-115 NW\sXYdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfKdpFKSzVyPUGuNFY3PTZizszN M1vCSXNCVkeHUh?=
CAL-54 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfIUWdKSzVyPUGuNFcxQDFizszN NETRc2dUSU6JRWK=
TGBC24TKB NUm1UWFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrSTWM2OD1zLkC4NFQ2KM7:TR?= MUHTRW5ITVJ?
NCI-H520 NXLKeJR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zKWmlEPTB;MT6wPFk3PyEQvF2= M1HFWnNCVkeHUh?=
D-423MG MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTFwMEm5OlIh|ryP MoDoV2FPT0WU
BFTC-905 MnnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LzS2lEPTB;MT6xN|Q1QSEQvF2= NWTHUGk{W0GQR1XS
HT MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX6Z5hUUUN3ME2xMlE{PDd6IN88US=> NGrldohUSU6JRWK=
CTB-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M172bmlEPTB;MT6xOFI6OyEQvF2= MW\TRW5ITVJ?
Hs-578-T NUDZfIVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoGxTWM2OD1zLkG5OVY2KM7:TR?= MnHWV2FPT0WU
HuH-7 M2LwVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTFwMkC5OFkh|ryP MkD2V2FPT0WU
LB996-RCC NGH3ZnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTFwMkKxO|ch|ryP MoPpV2FPT0WU
KYSE-270 Mn;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjRTWM2OD1zLkK5O|M1KM7:TR?= NX7zSZE6W0GQR1XS
A4-Fuk NYTWUY54T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vkcmlEPTB;MT6yPVk6OyEQvF2= NV75UoI6W0GQR1XS
A498 M163S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTFwM{C0O|Qh|ryP M2WwOHNCVkeHUh?=
SK-MEL-1 MoXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLyT2hKSzVyPUGuN|A3PzlizszN NXXGbFBVW0GQR1XS
AU565 NWHZc3plT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3he3c5UUN3ME2xMlMyQDZ|IN88US=> MUXTRW5ITVJ?
Saos-2 NUi4Z2dNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTVWotKSzVyPUGuN|MzODVizszN NX;UcGhXW0GQR1XS
A549 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTFwM{m5O{DPxE1? NGHuPZdUSU6JRWK=
BFTC-909 NYnlPYtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\aTWM2OD1zLkSzN|A2KM7:TR?= NHvjTGpUSU6JRWK=
MDA-MB-415 M1zoe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XLZmlEPTB;MT60PFY6OiEQvF2= NFK3PJRUSU6JRWK=
639-V NXi1boNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoS5TWM2OD1zLkWwNlQ2KM7:TR?= MYXTRW5ITVJ?
A704 Moe4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTFwNUC3PFUh|ryP M{fSe3NCVkeHUh?=
PANC-03-27 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjYcWdzUUN3ME2xMlUyPDB6IN88US=> NWHwcIRQW0GQR1XS
SK-MEL-28 M2rPSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFwNU[wPFUh|ryP NHu1UGNUSU6JRWK=
Ramos-2G6-4C10 NVfJWI1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTFwNkC3OFYh|ryP MYTTRW5ITVJ?
HuP-T4 Mn25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFwNkC3O|gh|ryP NFrjUZFUSU6JRWK=
VA-ES-BJ NHrjU|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPVU5dkUUN3ME2xMlYyOjdizszN MlLjV2FPT0WU
EFM-19 NVKxTm5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDyTWM2OD1zLk[xPFEh|ryP M3Lrb3NCVkeHUh?=
G-401 M1;WNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HneWlEPTB;MT62NlE3PCEQvF2= MYjTRW5ITVJ?
D-566MG NWfodlVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{i3PWlEPTB;MT62NlU{KM7:TR?= MX\TRW5ITVJ?
JVM-3 Mm\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTFwNkS4O|Uh|ryP NWjTfFZZW0GQR1XS
TK10 NWD2dHZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTFwNkewPFMh|ryP M2\kdnNCVkeHUh?=
BT-20 M{TzVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fyUWlEPTB;MT62PFkxOiEQvF2= MVPTRW5ITVJ?
EGI-1 Mo[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4K5VGlEPTB;MT64OFcxOSEQvF2= M1\IVHNCVkeHUh?=
EW-16 MkjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zVPWlEPTB;MT64OVE5OiEQvF2= NXTJcYxLW0GQR1XS
NCI-H2228 NFfsbGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1KwcGlEPTB;MT64OVIxOyEQvF2= MVLTRW5ITVJ?
BB49-HNC MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;pUGlEPTB;MT64PFY6OiEQvF2= M{T2VXNCVkeHUh?=
G-402 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTFwOEm3PVch|ryP NHrCNJpUSU6JRWK=
NCI-H526 NEi3Xo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnnTWM2OD1zLkmxN|kh|ryP NGPvZVZUSU6JRWK=
ME-180 NFW4[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7wTWM2OD1zLkmzOFc4KM7:TR?= M3PQ[HNCVkeHUh?=
PFSK-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrrTXBKSzVyPUGuPVQ1PThizszN NWDpb2VoW0GQR1XS
TYK-nu MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTFwOUW4NlMh|ryP M3P2Z3NCVkeHUh?=
HOS MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTFwOUe5OFgh|ryP MknwV2FPT0WU
T98G NGK0epBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HSc2lEPTB;MT65PVAxPiEQvF2= MV7TRW5ITVJ?
SK-MES-1 Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTtNYx5UUN3ME2yMlAyOzN{IN88US=> MW\TRW5ITVJ?
SNB75 M37RVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3z2UGlEPTB;Mj6wNVU1OSEQvF2= NV:1bZFtW0GQR1XS
LAMA-84 NHHlS3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;He41JUUN3ME2yMlAzPjh7IN88US=> NYPKSpRoW0GQR1XS
CAL-39 NH:1OIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXIUZpKSzVyPUKuNFMzQCEQvF2= MkKxV2FPT0WU
LOXIMVI NFfvVYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDhPY1YUUN3ME2yMlA1ODh2IN88US=> M4fJUXNCVkeHUh?=
NH-12 NYGxZ|ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYftV|liUUN3ME2yMlA2PDJ2IN88US=> M3;Xb3NCVkeHUh?=
NCI-H1048 MmL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HtT2lEPTB;Mj6xNFUzKM7:TR?= NFfhSHlUSU6JRWK=
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RH-18 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXwT5oxUUN3ME24MlM2ODR4IN88US=> MYPTRW5ITVJ?
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RXF393 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYC2O5IyUUN3ME25MlQ4ODB{IN88US=> NFPpeoxUSU6JRWK=
CGTH-W-1 NUj3dHVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1y2bmlEPTB;OT60PVM5PCEQvF2= MULTRW5ITVJ?
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KLE MnPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fsdGlEPTB;OT63NFAxQSEQvF2= MXHTRW5ITVJ?
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DEL NFfJOHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjxZXJYUUN3ME2xNE4{Pzl2IN88US=> NEOzOZJUSU6JRWK=
HT55 NGK4NZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTFyLk[yNFUh|ryP MknwV2FPT0WU
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RCC10RGB M4fCOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnkfplsUUN3ME2xNU4yOzVizszN NWjN[HJsW0GQR1XS
NMC-G1 M3nNTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTFzLkG0PVMh|ryP MYfTRW5ITVJ?
NCI-H650 MmHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3IbGJKSzVyPUGxMlM4QTRizszN MoX6V2FPT0WU
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DU-4475 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHoT2hiUUN3ME2xNU44Ozl|IN88US=> M2jZSnNCVkeHUh?=
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LB2518-MEL MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nIOWlEPTB;MUKuNFU6KM7:TR?= MWjTRW5ITVJ?
KALS-1 MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWr6NVM6UUN3ME2xNk45PTV|IN88US=> M3LMbHNCVkeHUh?=
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CHP-134 M1jsR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUK2O5pXUUN3ME2xN{4yOTV6IN88US=> MnfFV2FPT0WU
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DB MlK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfzc|JtUUN3ME2xN{45Ozh2IN88US=> NHz5Tm9USU6JRWK=
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LB771-HNC NFjUfHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rrTGlEPTB;MU[uOFQzOiEQvF2= Mk\3V2FPT0WU
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MDA-MB-231 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTF4LkexN|Yh|ryP MVXTRW5ITVJ?
TGW NFnkfGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHBTWM2OD1zNj64NVAzKM7:TR?= NIX2UZpUSU6JRWK=
MDA-MB-453 NXX3Z3hXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTiTWM2OD1zNz6wNFA{KM7:TR?= M1TiO3NCVkeHUh?=
SNU-C2B MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fnWmlEPTB;MUeuNFI{PyEQvF2= M2qxVnNCVkeHUh?=
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NCI-H1793 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF6LkG1PFEh|ryP M{fmZXNCVkeHUh?=
HCC1395 NH;0WmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHSyN5FKSzVyPUG4MlU3OTFizszN NXz2cFhtW0GQR1XS
NUGC-3 Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vVN2lEPTB;MUiuOlU5PCEQvF2= NF6wcpRUSU6JRWK=
BB65-RCC NIPLXnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF6Lk[2PUDPxE1? M2\x[3NCVkeHUh?=
RMG-I MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnS5TWM2OD1zOD63N|gzKM7:TR?= NXPsW3R[W0GQR1XS
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MFM-223 NFnhSnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnZTWM2OD1zOT6wO|E3KM7:TR?= NXfp[ZV[W0GQR1XS
NCI-H727 MlLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XvdGlEPTB;MUmuN|I6PSEQvF2= M2\VSHNCVkeHUh?=
KP-4 NFHUVHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTF7Lki1N|Eh|ryP NGP3WldUSU6JRWK=
NB13 NHXYfFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;4TWM2OD1zOT64PFM6KM7:TR?= MmrSV2FPT0WU
UACC-893 M1zKTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTF7Lkm3OVch|ryP MYnTRW5ITVJ?
HT-1197 NV:0ZVd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIn3N3lKSzVyPUKwMlI6PThizszN NIfwdJJUSU6JRWK=
NCI-H2029 NFLDSIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1n1OmlEPTB;MkCuN|I3PiEQvF2= NFLuRndUSU6JRWK=
GI-ME-N NInYVFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PtPWlEPTB;MkCuN|M4OyEQvF2= NHHXZmVUSU6JRWK=
OVCAR-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjpTWM2OD1{MD61PFIzKM7:TR?= NXOwWFFWW0GQR1XS
HD-MY-Z NYWwVVlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfmeFFKSzVyPUKxMlM3QTZizszN MoDoV2FPT0WU
NTERA-S-cl-D1 Ml\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT0ZZA6UUN3ME2yNU43PzJ{IN88US=> M322RXNCVkeHUh?=
SCH NYHzb5NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW3NYVKSzVyPUKyMlQ6PiEQvF2= MYLTRW5ITVJ?
KARPAS-299 NITOUpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T1VmlEPTB;MkOuN|g5PyEQvF2= MYrTRW5ITVJ?
NCI-H1650 MmLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPnTWM2OD1{Mz65NlQyKM7:TR?= NFXUVVNUSU6JRWK=
ACHN MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHCRlJDUUN3ME2yOE41PjV4IN88US=> MXzTRW5ITVJ?
M059J MlHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PmcGlEPTB;MkSuOVY{PCEQvF2= M4PWTnNCVkeHUh?=
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COLO-824 M3zMT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn5TWM2OD1{NT61OVk6KM7:TR?= M1HRNHNCVkeHUh?=
NCI-H1155 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTJ3LkW4OFch|ryP MXfTRW5ITVJ?
NCI-H441 NHvNfopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVr4R2NMUUN3ME2yOU44PDZ3IN88US=> NFTWV2VUSU6JRWK=
J-RT3-T3-5 M130O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PjbGlEPTB;Mk[uN|AzPyEQvF2= M4\tPHNCVkeHUh?=
JEG-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4P1RmlEPTB;Mk[uOlgxPSEQvF2= MlnGV2FPT0WU
RKO M{m2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXwPHRKSzVyPUK2Mlc3OzJizszN NYXqOmpzW0GQR1XS
CAL-85-1 NVXJV4ZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnUV4lKSzVyPUK3MlIyOThizszN Mmj5V2FPT0WU
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NCI-H2452 M3fWOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHf4bphKSzVyPUK3Mlc4OTZizszN NGjFdZhUSU6JRWK=
NCI-H1395 NUjrdG5qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zDbmlEPTB;MkeuO|g{OyEQvF2= NU\1dZF4W0GQR1XS
KYSE-450 M1j0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jCNWlEPTB;MkeuPVg3OiEQvF2= MojSV2FPT0WU
S-117 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTwTWM2OD1{OT6zPFU4KM7:TR?= M{T3XHNCVkeHUh?=
SW13 MoLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTQXXF3UUN3ME2yPU45PTF7IN88US=> M{\RNnNCVkeHUh?=
ES3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfDTVFDUUN3ME2zNE4{PzN|IN88US=> M37LSHNCVkeHUh?=
HCT-116 MlPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vsWmlEPTB;M{CuOVU2PCEQvF2= M2X1R3NCVkeHUh?=
NCI-H1693 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn0TWM2OD1|MD61PVQzKM7:TR?= NUm4O4pQW0GQR1XS
VM-CUB-1 M4rTR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLxSY1KSzVyPUOwMlY1OTNizszN M1vuRnNCVkeHUh?=
NCI-H2170 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LEd2lEPTB;M{GuOVc5PCEQvF2= MVnTRW5ITVJ?
ALL-PO NH23[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHDWZVKSzVyPUOxMlg1OjhizszN MVPTRW5ITVJ?
NCI-H661 M2\HXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTiTWM2OD1|Mj6wOlI{KM7:TR?= NWrUcodvW0GQR1XS
NCI-H2347 M2jF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LXS2lEPTB;M{KuOFg{PyEQvF2= NWSxWnBbW0GQR1XS
FTC-133 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTN{LkewOkDPxE1? MVjTRW5ITVJ?
COLO-829 NX7aWVNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzHU2pKSzVyPUOzMlM1PjdizszN M3TzTnNCVkeHUh?=
GOTO MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGzTWM2OD1|Mz61NlU5KM7:TR?= NVG4bW54W0GQR1XS
YAPC Mk\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fufWlEPTB;M{OuPFE2QSEQvF2= MkOyV2FPT0WU
LCLC-103H MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D1ZmlEPTB;M{SuNVYzPCEQvF2= NU\4ZlNSW0GQR1XS
SiHa M1TWNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfJOFdJUUN3ME2zOE4{QDF5IN88US=> NXPQU2pIW0GQR1XS
LK-2 NYmzPVFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHYcYhKSzVyPUO0MlU4ODhizszN NXHqbZV1W0GQR1XS
KP-N-YS M4f4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP2TWM2OD1|ND63NlAzKM7:TR?= NGLDOHVUSU6JRWK=
NCI-SNU-1 Mn25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfLcY9WUUN3ME2zOU4yPzlizszN M{fZdnNCVkeHUh?=
KNS-81-FD NH7uXIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTN3Lk[2N{DPxE1? MlnlV2FPT0WU
SCC-9 M1\tOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTN4LkexOFYh|ryP MkX5V2FPT0WU
SH-4 M{Lpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTN4LkezJO69VQ>? Ml7NV2FPT0WU
HCC-1954 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;UTWM2OD1|Nz6yO|I6KM7:TR?= MkjPV2FPT0WU
BALL-1 NWfSS4ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPSe29KSzVyPUO3MlU{OTZizszN Mmr1V2FPT0WU
BE-13 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHNbWpKSzVyPUO3MlcxOThizszN NYfUcVJiW0GQR1XS
COLO-678 NYT5eXRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTN5Lkm0N|ch|ryP M{PZd3NCVkeHUh?=
SK-MEL-3 NGK3XnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXK4W4dMUUN3ME2zPE4zOzl5IN88US=> NEHmdYNUSU6JRWK=
OAW-28 NXiw[YVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTN6Lk[zPUDPxE1? MlXRV2FPT0WU
CAMA-1 M1X6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\iOotJUUN3ME2zPE46PjlzIN88US=> MofIV2FPT0WU
C2BBe1 MnfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\CTWM2OD1|OT64NVgh|ryP NIPEcI9USU6JRWK=
A3-KAW Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3HS4xKSzVyPUSwMlM3PjFizszN NH[3bWpUSU6JRWK=
SK-MEL-24 NWi4d3NKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{mzPWlEPTB;NECuOVk{OSEQvF2= NYTDVmNHW0GQR1XS
KYSE-140 M{m3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrTeoZKSzVyPUSwMlcyPjVizszN MWPTRW5ITVJ?
MOLT-16 NEDqeFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\hTWM2OD12MT6xOVM3KM7:TR?= NWi4RYNlW0GQR1XS
CFPAC-1 Ml;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\ybWJ{UUN3ME20Nk42OjFzIN88US=> MoTaV2FPT0WU
NB14 M{HscWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:3bGlEPTB;NEKuO|AzPyEQvF2= M4n1cXNCVkeHUh?=
COLO-792 Mon1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTR{Lki5OlEh|ryP MnXYV2FPT0WU
RH-1 MoLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTR|LkS4N|Yh|ryP NGPxOG9USU6JRWK=
NCI-H522 M3rsTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTR2LkO1Olgh|ryP M3PBcHNCVkeHUh?=
Ca-Ski NVXsWmkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTR2LkixNVQh|ryP NVj1Tm1qW0GQR1XS
KGN Mn3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLufXN2UUN3ME20PE4{ODZ|IN88US=> NX7L[FVjW0GQR1XS
UACC-62 NFL1PWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTR6LkSwO|Ih|ryP NHnMZ3RUSU6JRWK=
NCI-H358 M2DQUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTsTWM2OD12OT6zNFE5KM7:TR?= NWPMe5RuW0GQR1XS
LS-411N NVW1bmxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYflZpJFUUN3ME20PU4{OTF6IN88US=> MYfTRW5ITVJ?
IST-MES1 MknkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXYTVk5UUN3ME20PU42PjJ3IN88US=> MorzV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-FoxO3a / FoxO3a / PUMA; 

PubMed: 29137323     


HCT116 cells were treated with 4μmol/L NVP-BKM120 or 4μmol/L Pictilisib for 24 hours. Indicated protein levels were analyzed by Western blotting.

p-S6RP / S6RP; 

PubMed: 30042442     


Western blot analysis of proteins as indicated in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. Vinculin was used as a loading control. 

p-4EBP1 / 4EBP1; 

PubMed: 25857298     


Cells were treated with 0.5 μM GDC-0941 for the indicated time course and then collected for Western blot analysis of p-4EBP1. 

p-LRP6 / LRP6; 

PubMed: 25857298     


MDAMB-231, HCC1937 and MCF7 cells were treated with 0.5 µM GDC-0941 for 1 hr, and cell lysates were used for immunoblot analyses.

p-PAK / PAK1 / p-CRAF / RAF / p-MEK / MEK / p-ERK / ERK; 

PubMed: 24327733     


Cells were treated with 1 μM GDC-0941 for the indicated times, and lysates were probed with the indicated antibodies. Independent experiments were performed at least three times, and a representative result is shown.

29137323 30042442 25857298 24327733
Immunofluorescence
p65; 

PubMed: 30042442     


Representative images of immunofluorescent staining of p65 cellular localization in 4T1 cells treated with 1 µM GDC-0941 or vehicle for 24 h. 4T1 cells were cultured alone or co-cultured with RAW264.7 macrophages. Representative images of three independent experiments are shown. 

beta-catenin; 

PubMed: 25857298     


Cells were seeded on coverslips the day before the experiment and treated with 0.5 µM GDC-0941 for 18 hr. The immunofluorescence (IF) of beta-catenin is indicated as red fluorescence, and double staining with DAPI is blue. Magnification: 400 X for the left three panels. The right panel shows enlarged images from the white squares.

30042442 25857298
Growth inhibition assay
Cell viability; 

PubMed: 27117832     


The viability of the indicated cells treated with increasing concentrations of GDC-0941 (ranging from 70nM to 20 μM) for 72 hours, determined by CellTiter Glo Viability assay. The IC50 concentrations were calculated using GraphPad Prism program. The assay was performed in triplicate, and the error bars represent standard deviations.

27117832
体内研究 在微粒体中,GDC-0941仅有有限的代谢,其口服生物利用度为78%[5]。GDC-0941 每天按 75 mg/kg剂量处理携带人U87MG 恶性胶质移植瘤的雌性NCr无胸腺小鼠,显著抑制生长,肿瘤生长抑制率为 83%。[1]GDC-0941 每天按 150 mg/kg剂量口服处理携带HER2扩增的抗Trastuzumab的MDA-MB-361.1移植瘤 的小鼠,抑制肿瘤生长,且显著延迟肿瘤衰退,与肿瘤中强诱导型凋亡相关。[2] GDC-0941 每天按75 mg/kg剂量处理携带自发性B细胞滤泡性淋巴瘤的PTEN+/-LKB1+/hypo小鼠,持续2周,诱导肿瘤体积下降~40%,伴随着AKT, S6K 和SGK(血清和糖皮质激素蛋白激酶)蛋白激酶的磷酸化被切除。GDC-0941抑制肿瘤细胞增殖,诱导凋亡和抑制中心母细胞数。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

闪烁接近检测:

使用p85α调节亚基,使重组人PI3Kα, PI3Kβ, 和PI3Kδ在 Sf9 杆状病毒系统中共表达,在谷胱甘肽-琼脂糖凝胶上进行亲和层析而纯化GST-融合蛋白。重组人 PI3Kγ表达作为单体 GST融合,也想上述相似方法纯化。GDC-0941 溶于DMSO,加到含200 μg硅酸钇(Ysi) 聚赖氨酸SPA 磁珠, 4 mM MgCl2, 1 mM 二硫苏糖醇 (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, 和4% (v/v) DMSO的20 mM Tris-HCl (pH 7.5)上,总体积为 50 μL。PI3Kα (5 ng), PI3Kβ(5 ng), PI3Kδ(5 ng), 或PI3Kγ(5 ng)的重组GST-融合 ,加到实验混合物中,开始激酶反应。在室温下温育1小时后, 加入150 μL PBS终止反应。混合物在2000 rpm 转速下离心2分钟,然后使用Wallac Microbeta计数器读数。在 MDL Assay Explorer系统中使用S型,剂量-反应曲线,计算进行至少2次独立重复实验,取平均值,作为IC50值。
细胞实验:

[2]

- 合并
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, 和MKN-7
  • Concentrations: 溶于DMSO,终浓度为~10 μM
  • Incubation Time: 48,和72小时
  • Method:

    使用不同浓度 GDC-0941处理细胞48,和 72小时。通过CellTiter-Glo Luminescent细胞活性检测实验测定细胞增殖/活力。通过Western Blot分析pAKT (Ser473), cleaved caspase-3, 和cleaved PARP通过 Caspase-Glo 3/7实验和细胞死亡检测 ELISAplus 实验分别测定caspase 3/7活性, 和凋亡。


    (Only for Reference)
动物实验:

[2]

- 合并
  • Animal Models: 移植MDA-MB-361.1细胞的NCR裸鼠, 皮下移植BT474-M1 细胞的SCID, C.B-17/IcrHsd-Prkdcscid 小鼠
  • Dosages: ~150 mg/kg/day
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 513.64
化学式

C23H27N7O3S2

CAS号 957054-30-7
储存条件 粉状
溶于溶剂
别名 RG7321

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):