Pictilisib (GDC-0941)

For research use only. Not for use in humans.

目录号：S1065 别名： RG7321

Pictilisib (GDC-0941) Chemical Structure

CAS No. 957054-30-7

Pictilisib (GDC-0941, RG7321) 是一种有效的PI3Kα/δ抑制剂，在无细胞试验中IC50为 3 nM，对p110β (11倍)和p110γ (25倍)具有适度的选择性。Pictilisib (GDC-0941) 可诱导自噬和凋亡。Phase 2。

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购买数量

10mM (1mL in DMSO)	RMB 1972.48	现货
5mg	RMB 986.88	现货
50mg	RMB 3026.17	现货
200mg	RMB 7926.11	现货
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客户使用Selleck生产的Pictilisib (GDC-0941)发表文献363篇：

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产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述

靶点

p110α ^[1] (Cell-free assay)	p110δ ^[1] (Cell-free assay)	p110β ^[1] (Cell-free assay)	p110γ ^[1] (Cell-free assay)	mTOR ^[1] (Cell-free assay)
3 nM	3 nM	33 nM	75 nM	0.58 μM(Ki app)

体外研究

GDC-0941也等效作用于PI3Kα和 PI3Kδ和PI3Kα突变型E545-K和H1047-R,也选择性作用于PI3Kβ(10倍)和 PI3Kγ(25倍), 选择性更高地作用于PI3K II, III, 和IV类成员，包括, C2β, Vps34, DNA-PK和mTOR。GDC-0941 作用于U87MG, PC3, 和 MDA-MB-361 细胞，有效抑制Akt磷酸化，IC50分别为46 nM, 37 nM,和 28 nM。GDC-0941抑制U87MG, A2780, PC3, 和MDA-MB-361细胞增殖，IC50分别为 0.95 μM, 0.14 μM, 0.28 μM, 和0.72 μM。^[1]GDC-0941处理，有效抑制对Trastuzumab敏感和不敏感的HER2扩增细胞增殖，IC50为149-944 nM,与 Trastuzumab敏感性无关。GDC-0941抑制含PIK3CA突变的HER2扩增的细胞增殖，IC50<500 nM, 且有效抑制抗trastuzumab 的HER2 扩增乳腺癌细胞增殖和活力。^[2]GDC-0941 显著抑制HCT116, DLD1和 HT29细胞生长，GI50分别为1081 nM, 1070 nM 和157 nM。^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
Sf9	NES1TWRMcW6jc3WgRZN{[Xl?		NF\USI4yKGh?	M4fXOWROW09?	NYW4fWFYUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDk[Yx1[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[SC5aYToJGlEPTBib3[gNE4xODNizszN	NF3xTY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEe1OFY2PCd-MUi3OVQ3PTR:L3G+
Sf9	M4LQU2tqdmG\|ZTDBd5NigQ>?		NISwcHUyKGh?	MmHMSG1UVw>?	MYLJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgTFExPDdvUjDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB\|IN88US=>	Ml3aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh5NUS2OVQoRjF6N{W0OlU1RC:jPh?=
Sf9	MmPOT4lv[XOnIFHzd4F6		MlnrNUBp	MXTEUXNQ	MnHaTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCkZYThJGU2PDVvSzDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB\|IN88US=>	NWrDN2JSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3OVQ3PTRpPkG4O\|U1PjV2PD;hQi=>
Sf9	M12x[GtqdmG\|ZTDBd5NigQ>?		NFfZWIgyKGh?	MnHpSG1UVw>?	NI\GdXhKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIEhf2m2aDDJR\|UxKG:oIECuNFM{KM7:TR?=	MmLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh5NUS2OVQoRjF6N{W0OlU1RC:jPh?=
Sf9	M3jKfmtqdmG\|ZTDBd5NigQ>?		M{HlbFEhcA>?	MkK0SG1UVw>?	Mkm5TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCjbIDoZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy\|IHPv[ZhxemW\|c3nu[{BxQDWjbIDoZS=>	NGrEeWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEe1OFY2PCd-MUi3OVQ3PTR:L3G+
MDA-MB-361	NGfacFhHfW6ldHnvckBCe3OjeR?=		NETmU4EzKGh?	NXzXXIwxTE2VTx?=	Moi5TY5pcWKrdHnvckBw\iCDa4SgV4VzPDd\|IIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCPRFGtUWIuOzZzIHPlcIx{KHerdHigVGlMO0ODIFW1OFUuUyCvdYTheIlwdiC5aYToJGlEPTBib3[gNE4xOjhizszN	NXr3[XkzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3OVQ3PTRpPkG4O\|U1PjV2PD;hQi=>
PC3	MYjGeY5kfGmxbjDBd5NigQ>?		MVOyJIg>	M3[0WWROW09?	NFzvbGZKdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDQR\|Mh[2WubIOge4l1cCCLQ{WwJI9nKDBwMEO3JO69VQ>?	M1zPclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{W0OlU1Lz5zOEe1OFY2PDxxYU6=
U87MG	MVvGeY5kfGmxbjDBd5NigQ>?		M17WcVIhcA>?	NVTa[WRRTE2VTx?=	M{nVSmlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25iaX6gVHRGVi2wdXzsJIh2dWGwIGW4O21IKGOnbHzzJJdqfGhiSVO1NEBw\iByLkC0OkDPxE1?	M3zMbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{W0OlU1Lz5zOEe1OFY2PDxxYU6=
MDA-MB-361	NFr4N5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MmD5PVYhcA>?	MVPEUXNQ	M3HBfGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTN4MTDj[YxteyC5aYToJHBKUzOFQTDFOVQ2NUtibYX0ZZRqd25id3n0bEBKSzVyIH;mJFAvPzJizszN	NVe0d5ZORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3OVQ3PTRpPkG4O\|U1PjV2PD;hQi=>
A2780	M2jzVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NHns[m46PiCq	MVzEUXNQ	MoL5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCDMke4NEBk\WyuczD3bZRpKFCLS{PDRUBidmRiUGTFUkBufXSjdHnvckB4cXSqIFnDOVAhd2ZiMD6xOEDPxE1?	Mly1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh5NUS2OVQoRjF6N{W0OlU1RC:jPh?=
PC3	M{P1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NUK4VGpUQTZiaB?=	MVzEUXNQ	M32wc2lEPTB;MD6yPEDPxE1?	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDd3NE[1OEc,OTh5NUS2OVQ9N2F-
U87MG	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NV76c5VJQTZiaB?=	NW\EVohqTE2VTx?=	NITG[HdKSzVyPUCuPVUh\|ryP	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDd3NE[1OEc,OTh5NUS2OVQ9N2F-
Sf9	NYDJNmw3U2mwYYPlJGF{e2G7		M2K3NlMxKG2rbh?=	MmS0SG1UVw>?	NWThTnBIUW6qaXLpeIlwdiCxZjDoeY1idiCSSUPL[4FudWFiZYjwdoV{e2WmIHHzd4V{e2WmIHHzJIFud3WwdDDv[kBCXFBiY3;ud5Vu\WRid3n0bEBKSzVyIH;mJFAvODR{IN88US=>	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV2OEO0Nkc,OjJ3NEizOFI9N2F-
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DMS273	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIrLbFVtd2eJSUWwQU03NjR\|IF2=	Mmr1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
DMS114	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NX\sd2ZqdG:pR1m1NF0uPS57MjDN	M2fjbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
LOXIMVI	M2rYTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mmj4cI9oT0l3ME2tOk4zQSCP	M3jSUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
OVCAR3	M3;ofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{X5OIxw\0eLNUC9MVYvPzFiTR?=	NWDZTW9ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN\|YzPDZpPkKyN\|M3OjR4PD;hQi=>
OVCAR4	NYnIVFdnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHvHOIVtd2eJSUWwQU02Njd4IF2=	MnPuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
OVCAR5	NInqVnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2n0Ooxw\0eLNUC9MVYvOjZiTR?=	NYD3[JZuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN\|YzPDZpPkKyN\|M3OjR4PD;hQi=>
OVCAR8	NWTVXXVsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUTsc4dIUTVyPT21Mlc{KE1?	MkLDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
SKOV3	MkDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIG5Xo9td2eJSUWwQU03NjV{IF2=	M{fOVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
RXF631L	NEfafpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MU\sc4dIUTVyPT22Mlg5KE1?	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN\|NkK0Okc,OjJ\|M{[yOFY9N2F-
ACHN	NXTsOppyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHXtOGptd2eJSUWwQU03NjB5IF2=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN\|NkK0Okc,OjJ\|M{[yOFY9N2F-
St-4	NYrOTmFbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYrGfHBydG:pR1m1NF0uPS53NjDN	MljUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
MKN1	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV7sc4dIUTVyPT23MlA5KE1?	NVfJWJNqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN\|YzPDZpPkKyN\|M3OjR4PD;hQi=>
MKN7	NVPEcHdDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3zyW4xw\0eLNUC9MVYvPTBiTR?=	M{PHT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
MKN28	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{fIRYxw\0eLNUC9MVUvPTJiTR?=	NV\iR2tyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN\|YzPDZpPkKyN\|M3OjR4PD;hQi=>
MKN45	MojxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{Lteoxw\0eLNUC9MVYvPTViTR?=	NGLJN2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN\|YzPDZ:L3G+
MKN74	NXPmZpJXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXfsc4dIUTVyPT22MlAzKE1?	NH3mblQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN\|YzPDZ:L3G+
DU145	Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mk\5cI9oT0l3ME2tOU45PSCP	NWqyZpFKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN\|YzPDZpPkKyN\|M3OjR4PD;hQi=>
PC3	Ml[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYnMdItEdG:pR1m1NF0uPi54NjDN	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN\|NkK0Okc,OjJ\|M{[yOFY9N2F-
ES5	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF7mbYFKSzVyPUWwMlIyKG6P	NFXqTXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF6NUGvK\|5USU6JRWK8M4E,
HH	NYrhW\|BsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXvMOIFCUUN3ME2xNVEvODhibl2=	M4[2elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTh3MT:nQnNCVkeHUkyvZV4>
MHH-PREB-1	NIPzfmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{GydmlEPTB;MUG0MlMhdk1?	NY\WNJc3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
NCI-H1770	NHzld4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{XQ[mlEPTB;MUKzMlg3KG6P	NWDLUVkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
HuO9	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoHTTWM2OD1{ME[uNFIhdk1?	NUHwdG9mRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
HAL-01	M1jIcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUfTToVVUUN3ME2yNFYvPzNibl2=	NWrNS\|dRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
NOS-1	NHTHd4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4ruNGlEPTB;MkGxMlgzKG6P	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE5PTFxJ{7TRW5ITVJ:L3G+
HGC-27	MnHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVPJR\|UxRTJzMj61O{BvVQ>?	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE5PTFxJ{7TRW5ITVJ:L3G+
NB69	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2nuN2lEPTB;MkS1MlI4KG6P	NY\GRno{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
RS4-11	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmD5TWM2OD1{NkGuO\|Yhdk1?	NGnpSYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF6NUGvK\|5USU6JRWK8M4E,
DOK	M1jpWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnjGTWM2OD1\|MEGuO{BvVQ>?	NH7jS4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF6NUGvK\|5USU6JRWK8M4E,
LB2241-RCC	MkjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml;FTWM2OD1\|MEOuPFQhdk1?	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE5PTFxJ{7TRW5ITVJ:L3G+
NCI-H1623	NHPpO45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYHDfHFGUUN3ME2zNFQvODhibl2=	NIrBcmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF6NUGvK\|5USU6JRWK8M4E,
YH-13	MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3m0[WlEPTB;M{C0MlMzKG6P	MknVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyQDVzLze+V2FPT0WUPD;hQi=>
BPH-1	NVHWVVg5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWnJR\|UxRTNzNDDuUS=>	M4HJblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTh3MT:nQnNCVkeHUkyvZV4>
AN3-CA	NY\hUGlbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWrJR\|UxRTN2MD6zO{BvVQ>?	NXntSHVSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
ES7	NYrEU\|hWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3\EO2lEPTB;M{SxMlk6KG6P	NF\nN5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF6NUGvK\|5USU6JRWK8M4E,
MDA-MB-175-VII	M3rRNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3zSNmlEPTB;M{WyMlkzKG6P	NXjtTlY2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
GAMG	M3Xlc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkXFTWM2OD1\|N{CuPFUhdk1?	NV;0cmdERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
CHL-1	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoW0TWM2OD1\|N{iuOlUhdk1?	NWm4col{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
NB7	NWfpfXp6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoLpTWM2OD1\|OEmuPFMhdk1?	M2HLXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTh3MT:nQnNCVkeHUkyvZV4>
MFE-280	MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVnzWVVTUUN3ME20NVgvOiCwTR?=	MlrmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyQDVzLze+V2FPT0WUPD;hQi=>
HL-60	MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoTBTWM2OD12MkWuO\|Uhdk1?	MoPzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyQDVzLze+V2FPT0WUPD;hQi=>
GCIY	NX7WNY5PT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2DSRWlEPTB;NEOzMlghdk1?	NVGy[GFTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
MDA-MB-361	NHTKSlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{T5bGlEPTB;NEO5MlE{KG6P	NU\1cW92RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
LXF-289	MkniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIex[3pKSzVyPUS0PE4zPyCwTR?=	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE5PTFxJ{7TRW5ITVJ:L3G+
NBsusSR	MlnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2rReGlEPTB;NEi4Mlg2KG6P	MofzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyQDVzLze+V2FPT0WUPD;hQi=>
KU-19-19	M{LV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4K3e2lEPTB;NUG2MlA4KG6P	MlXBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyQDVzLze+V2FPT0WUPD;hQi=>
A204	Ml;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnjtTWM2OD13MkKuN\|Mhdk1?	MmL1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyQDVzLze+V2FPT0WUPD;hQi=>
LB1047-RCC	NWXLOZRpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{PNTWlEPTB;NUKyMlk{KG6P	NXOwfWxSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
COLO-684	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M17qT2lEPTB;NUKzMlEyKG6P	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE5PTFxJ{7TRW5ITVJ:L3G+
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DK-MG	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXrJR\|UxRTRwM{CzPUDPxE1?	NWHNW5hqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
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FADU	M4f6O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGTSWIhKSzVyPUSuN\|c1PjdizszN	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE5PTFxJ{7TRW5ITVJ:L3G+
CAL-12T	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVH2SWFvUUN3ME20MlQyPDF\|IN88US=>	NHfEWFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF6NUGvK\|5USU6JRWK8M4E,
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LU-99A	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHLlfZlKSzVyPUSuOFYxPiEQvF2=	M1TSWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTh3MT:nQnNCVkeHUkyvZV4>
CAL-33	NUHJOopvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnvTTWM2OD12LkWyOFU3KM7:TR?=	M3jpR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTh3MT:nQnNCVkeHUkyvZV4>
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NCI-H1355	NW[2flQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mm\RTWM2OD12LkW1NVQ3KM7:TR?=	M4Dj[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTh3MT:nQnNCVkeHUkyvZV4>
RPMI-7951	M3vhfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4TPO2lEPTB;ND61O\|AxOiEQvF2=	NI\hfpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF6NUGvK\|5USU6JRWK8M4E,
TE-1	NIHvU2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEKzSGVKSzVyPUSuOlYyPDNizszN	NX;JSYtpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
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CAL-51	NHezRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnH6TWM2OD12LkexNFgzKM7:TR?=	M{G3T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTh3MT:nQnNCVkeHUkyvZV4>
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BT-474	NX7WUG46T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1;ZXmlEPTB;ND63OlM5PCEQvF2=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE5PTFxJ{7TRW5ITVJ:L3G+
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IA-LM	NIjabHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2S4TmlEPTB;ND65PVQ{PSEQvF2=	M3vHcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTh3MT:nQnNCVkeHUkyvZV4>
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RPMI-8226	M1XifWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmHMTWM2OD13LkC1OFYyKM7:TR?=	M1vFSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTh3MT:nQnNCVkeHUkyvZV4>
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A375	M{OyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVLzOFJZUUN3ME21MlA6OjV4IN88US=>	M1S4e\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTh3MT:nQnNCVkeHUkyvZV4>
8305C	MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NY\0SlY3UUN3ME21MlA6QDh5IN88US=>	NVHkfGdnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzOEWxM{c,W0GQR1XSQE9iRg>?
CAL-62	NIDJPJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWf1R4RyUUN3ME21MlE5OjV7IN88US=>	NELUXGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF6NUGvK\|5USU6JRWK8M4E,
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OC-314	NYLkOIxXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2Lyb2lEPTB;NT6zO\|Q1PCEQvF2=	NIfOOJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF6NUGvK\|5USU6JRWK8M4E,
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