Dactolisib (BEZ235, NVP-BEZ235)

目录号:S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Phase 2。

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客户使用Selleck该产品发表文献88篇:

客户使用该产品的11个实验数据:

  • Level of phospho-proteins in RTK and PI3K–Akt–mTOR pathways in treated tumours, detected with western blot.

    Nature, 2017, 728-732. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • (B) The effects of AZD2014, BEZ235, lapatinib, LEE011, pazopanib on PI3K/AKT signaling in sarcoma PDC line were determined by immunoblotting analysis. Cells were treated with 1 μM of the indicated drugs for 72 h.

    Transl Oncol, 2016, 9(3):197-202. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    The effects of LY294002, rapamycin and NVP-BEZ235 on activation of PI3K-Akt-mTOR pathway in hepatocytes. (a) The mRNA expression (PI3K, Akt, mTOR, raptor) by Real-Time PCR, (b) protein expression (PI3K, Akt, mTOR, S6K) by ELISA kits; (c) protein expression of S6K and P-S6K by western blotting. The different letters indicated significant differences (P <0.05). LY = LY294002; rapa = rapamycin; NVP = NVP-BEZ235.

    Animal, 2016, 10(8):1319-27. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Phase 2。
靶点
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
体外研究

BEZ235显著降低mTOR活化的激酶p70S6K的磷酸化水平。BEZ235导致S235/S236P-RPS6水平减少,IC50为6.5 nM。BEZ235抗mTOR的活性使用生化mTOR K-LISA试验测定,IC50为20.7 nM。BEZ235对其β旁系同源物的活性稍弱,IC50为75 nM。在人肿瘤细胞中,PI3K/Akt/mTOR通路经常被组成性活化。BEZ235阻断PI3K和mTOR激酶活性,通过结合于这些酶的ATP结合槽发挥作用。用逐渐增加浓度BEZ235处理PTEN-null细胞系PC3M和U87MG时,导致细胞增殖剂量依赖性减少,平均GI50为10-12 nM。[1] BEZ235是一种mTORC1/2催化抑制剂。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei M3LWPGFvfGmvaXPyc4Jq[WxiQYPzZZk> NFHB[IwyQCCq MYTEUXNQ NWD6WIpySW62aYTyfZBidm:|b33hcEBi[3Srdnn0fUB4cXSqIFXDOVAhd2ZiMD6wNFI2KM7:TR?= M3nITFI1QDB3OUS2
MCF7 M13YcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXewMlAyNTFyMDFOwG0> M1Hq[VQ5KGh? NGnvfo5FVVOR MUjJR|UxRTBwN{Og{txO NUTBSGN2OjN6N{G5NFQ>
HCT116 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TKVVAvODFvMUCwJO69VQ>? Mn;yOFghcA>? MlrBSG1UVw>? M1vkWWlEPTB;MT6xOkDPxE1? MYCyN|g4OTlyNB?=
U87MG NV3ZXm9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Tkb|AvODFvMUCwJO69VQ>? MoLqOFghcA>? MkDqSG1UVw>? Mn[yTWM2OD1zLkOyJO69VQ>? NX\LT5hUOjN6N{G5NFQ>
HBC4 NWnieGxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fWU|AvODFvMUCwJO69VQ>? NIPhbZo1QCCq MnnrUI9oKEeLNUC9MVgvPjFiTR?= MlrKNlI{OzZ{NE[=
BSY1 MmHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH3S2kxNjBzLUGwNEDPxE1? M1PnflQ5KGh? NXTadY56VG:pIFfJOVA:NThwNEigUS=> NHHqPVYzOjN|NkK0Oi=>
HBC5 NVnuNnRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\OdFAvODFvMUCwJO69VQ>? NHTEdpo1QCCq MXPMc4chT0l3ME2tO{45PyCP NELU[FIzOjN|NkK0Oi=>
MCF7 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XoUlAvODFvMUCwJO69VQ>? NX7mfG86PDhiaB?= Ml7KUI9oKEeLNUC9MVgvOTZiTR?= MYOyNlM{PjJ2Nh?=
MDA-MB-231 NYrrco5RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSwMlAyNTFyMDFOwG0> NEPNU401QCCq NIHUeFFNd2diR1m1NF0uQC5yOTDN NHPCW|MzOjN|NkK0Oi=>
U251 Mkm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXCNE4xOS1zMECg{txO NUHMO4dLPDhiaB?= M4\rOGxw\yCJSUWwQU04NjZ4IF2= M4npbFIzOzN4MkS2
SF268 Mn3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfXNE4xOS1zMECg{txO M2GzSlQ5KGh? NIXXZndNd2diR1m1NF0uPy57MjDN NFy4WFkzOjN|NkK0Oi=>
SF295 NYm5[4liT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX6NE4xOS1zMECg{txO MoO5OFghcA>? MnzPUI9oKEeLNUC9MVgvOzFiTR?= M3TXVFIzOzN4MkS2
SF539 M{j5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13XcFAvODFvMUCwJO69VQ>? NH3i[m41QCCq MlK5UI9oKEeLNUC9MVgvPTliTR?= MWCyNlM{PjJ2Nh?=
SNB75 NFTiflBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HoPFAvODFvMUCwJO69VQ>? NVzGUZpzPDhiaB?= M1XNR2xw\yCJSUWwQU05NjV6IF2= MlrwNlI{OzZ{NE[=
SNB78 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVuwMlAyNTFyMDFOwG0> NIXZSoo1QCCq MV;Mc4chT0l3ME2tPE43PSCP MUKyNlM{PjJ2Nh?=
HCC2998 M{H3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHBU2cxNjBzLUGwNEDPxE1? NHrPSIo1QCCq NXW5N4JNVG:pIFfJOVA:NThwMEWgUS=> MUGyNlM{PjJ2Nh?=
KM12 NUSwTogxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXTfG5KOC5yMT2xNFAh|ryP M3TyPVQ5KGh? M2X1[Wxw\yCJSUWwQU04NjV2IF2= NGCzTVczOjN|NkK0Oi=>
HT-29 NYrXRVBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWKwMlAyNTFyMDFOwG0> M{i1[|Q5KGh? MknJUI9oKEeLNUC9MVcvPzViTR?= NIrMNYczOjN|NkK0Oi=>
HCT15 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml:4NE4xOS1zMECg{txO NHu4[ZM1QCCq NWKyWpZzVG:pIFfJOVA:NThwMEOgUS=> MUiyNlM{PjJ2Nh?=
HCT116 NEfMRoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j6OVAvODFvMUCwJO69VQ>? Mnn5OFghcA>? M3zsW2xw\yCJSUWwQU04NjZzIF2= M33t[lIzOzN4MkS2
NCI-H23 NYPYZYhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj2U|UxNjBzLUGwNEDPxE1? M4HFPFQ5KGh? NFK2SXBNd2diR1m1NF0uPy54NDDN M4HqWFIzOzN4MkS2
NCI-H226 NGC1TYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfCZnMxNjBzLUGwNEDPxE1? M2fLdFQ5KGh? NXOwZ3hLVG:pIFfJOVA:NThwNESgUS=> MXeyNlM{PjJ2Nh?=
NCI-H522 MoToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVywMlAyNTFyMDFOwG0> MlTXOFghcA>? MojHUI9oKEeLNUC9MVgvPDViTR?= M16xSFIzOzN4MkS2
NCI-H438 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXGwMlAyNTFyMDFOwG0> M2jlc|Q5KGh? NGSwc5VNd2diR1m1NF0uQC5zMTDN NWXqR3ZWOjJ|M{[yOFY>
A549 NW\wVVJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHH0[FQxNjBzLUGwNEDPxE1? NFn5UJM1QCCq MorpUI9oKEeLNUC9MVgvODdiTR?= NWHqPFRnOjJ|M{[yOFY>
DMS273 MlvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXEbJgxNjBzLUGwNEDPxE1? MY[0PEBp M1HPZWxw\yCJSUWwQU04NjhyIF2= MYOyNlM{PjJ2Nh?=
DMS114 MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWOwMlAyNTFyMDFOwG0> M4rIPVQ5KGh? NHLnZ4dNd2diR1m1NF0uQC5|OTDN NELHbYMzOjN|NkK0Oi=>
LOXIMVI MnfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzLRpMxNjBzLUGwNEDPxE1? NVP6VZRzPDhiaB?= NYS5SpA2VG:pIFfJOVA:NThwNk[gUS=> M37BTlIzOzN4MkS2
OVCAR3 NYrNTIYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfH[2UxNjBzLUGwNEDPxE1? MYS0PEBp MV\Mc4chT0l3ME2tPE4yPyCP M{HUUFIzOzN4MkS2
OVCAR4 NIPPSGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e2VVAvODFvMUCwJO69VQ>? M1POR|Q5KGh? NVL1dJpXVG:pIFfJOVA:NThwNUigUS=> NW\5dZY2OjJ|M{[yOFY>
OVCAR5 NX;BT3NsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;LT|QxNjBzLUGwNEDPxE1? NYXPdlA1PDhiaB?= MVTMc4chT0l3ME2tO{42PyCP MWiyNlM{PjJ2Nh?=
OVCAR8 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrJcZYxNjBzLUGwNEDPxE1? NWPmUHVGPDhiaB?= NFTXWGNNd2diR1m1NF0uPy56NDDN NHH5SIozOjN|NkK0Oi=>
SKOV3 Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3O2PVAvODFvMUCwJO69VQ>? MUC0PEBp NXrxcHpTVG:pIFfJOVA:NThwNEGgUS=> NFLNR5kzOjN|NkK0Oi=>
RXF631L NYHQXJpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXuwMlAyNTFyMDFOwG0> NWnjWIVsPDhiaB?= M3LRU2xw\yCJSUWwQU05NjJzIF2= MWGyNlM{PjJ2Nh?=
ACHN MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrMXHNzOC5yMT2xNFAh|ryP MV:0PEBp MkXqUI9oKEeLNUC9MVcvQTViTR?= MUCyNlM{PjJ2Nh?=
St-4 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvwNE4xOS1zMECg{txO NXKyOldoPDhiaB?= M2jwe2xw\yCJSUWwQU04NjR5IF2= MnfsNlI{OzZ{NE[=
MKN1 NFrMcYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUWwMlAyNTFyMDFOwG0> MUm0PEBp MULMc4chT0l3ME2tPE41OSCP Mmf3NlI{OzZ{NE[=
MKN7 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;2dFAvODFvMUCwJO69VQ>? MlrtOFghcA>? NYLVbFJuVG:pIFfJOVA:NTdwNkigUS=> NEfSZVkzOjN|NkK0Oi=>
MKN28 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrObooxNjBzLUGwNEDPxE1? MYO0PEBp M1SzZWxw\yCJSUWwQU04NjB5IF2= MXeyNlM{PjJ2Nh?=
MKN45 M{L3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HtTlAvODFvMUCwJO69VQ>? M1v4b|Q5KGh? NH3Re3VNd2diR1m1NF0uQC5|NDDN MonSNlI{OzZ{NE[=
MKN74 MnXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVWwUoNHOC5yMT2xNFAh|ryP NUW0T5JGPDhiaB?= MoDVUI9oKEeLNUC9MVcvPDJiTR?= Mmj4NlI{OzZ{NE[=
DU145 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYOwMlAyNTFyMDFOwG0> MXK0PEBp NEXiN5FNd2diR1m1NF0uQC5zNjDN M4DFN|IzOzN4MkS2
PC3 Mn21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3remN4OC5yMT2xNFAh|ryP M{Xse|Q5KGh? NFjxPWVNd2diR1m1NF0uQC54NjDN NEnCd5ozOjN|NkK0Oi=>
Trypanosoma brucei brucei M3rKOGZ2dmO2aX;uJGF{e2G7 NYfIb3c2OjByIH7N M2XFVlEzKGh? M3nXVmROW09? MYrE[YNz\WG|ZTDpckBxcG:|cHjveIllgWxiaX7vd4l1d2xicHjvd5Bp[XSnIHzleoVt MWiyOFgxPTl2Nh?=
Trypanosoma brucei brucei NWW1N4pqTnWwY4Tpc44hSXO|YYm= NGjtRoUyQCCq NH74O2xFVVOR MV;Jcohq[mm2aX;uJI9nKHKnY3XweI9zNW2nZHnheIVlKGWwZH;jfZRwe2m|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHS{YX7z[oVzemmwIIXweIFs\Q>? NFH0TG8zPDhyNUm0Oi=>
Trypanosoma brucei brucei NGnjXVNHfW6ldHnvckBCe3OjeR?= MmmzNlAxKG6P MlryNVIhcA>? NXfGfFdVTE2VTx?= MXvF[oZm[3Rib36gd5BpcW6pb335cIVqdiCuZY\lcC=> MVmyOFgxPTl2Nh?=
Trypanosoma brucei brucei MUHGeY5kfGmxbjDBd5NigQ>? M3PTXlIxOCCwTR?= MnTJNVIhcA>? NIXITGlFVVOR NVnEVHBZTW[oZXP0JI9vKHCqb4PwbIF1cWS7bHPoc4xqdmVibHX2[Yw> NHvmenozPDhyNUm0Oi=>
UM-UC-3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLmTZp5UUN3ME2zNVUheE1? NEPqcFlUSU6JRWK=
SBC-1 MnPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrKTWM2OD15NEKgdG0> NH;p[nVUSU6JRWK=
MKN1 NEHBc4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrnTWM2OD1{Lkigcm0> MVTTRW5ITVJ?
NCI-H720 M3TCZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTNwNUegcm0> NUfITYY3W0GQR1XS
BFTC-909 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTNwN{Ggcm0> NYTJe3J3W0GQR1XS
BPH-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTRwN{[gcm0> MWXTRW5ITVJ?
PC-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DyWmlEPTB;NT6wPUBvVQ>? MoHOV2FPT0WU
AN3-CA MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fLZmlEPTB;NT61OkBvVQ>? MnjvV2FPT0WU
HN NWPjNXJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYKydZJlUUN3ME21Mlk3KG6P NF;0[WhUSU6JRWK=
HCC2218 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP6SIlKSzVyPU[uOlEhdk1? M4L3SXNCVkeHUh?=
KP-4 NETVTXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTdibl2= MV3TRW5ITVJ?
LU-139 NV;QU3FtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTdwN{egcm0> M{\1ZnNCVkeHUh?=
ETK-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTdwOEigcm0> NYLn[ZRDW0GQR1XS
Ramos-2G6-4C10 M{fYSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHKySmdKSzVyPUiuOFkhdk1? MWDTRW5ITVJ?
MHH-PREB-1 NVWycYk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrQem9KSzVyPUmuNVIhdk1? MkLSV2FPT0WU
DU-4475 MofKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfKVY5rUUN3ME25MlQ1KG6P NY\wSZJqW0GQR1XS
NCI-H1666 M1XwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjSTWM2OD17LkexJI5O NITUS2lUSU6JRWK=
CAMA-1 MkjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PaTWlEPTB;OT64JI5O MknVV2FPT0WU
TYK-nu M2HWcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYj2PIVIUUN3ME25Mlk1KG6P MojtV2FPT0WU
MFE-280 NUf4VpNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPNTWM2OD17Lkm5JI5O NULBXIhjW0GQR1XS
A549 NFrnZ2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;tNW04UUN3ME2xNE4yPCCwTR?= NVHI[3RwW0GQR1XS
769-P MlnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLtTWM2OD1zMD60OEBvVQ>? MVvTRW5ITVJ?
L-363 NGfI[WxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13oVGlEPTB;MUCuOlkhdk1? M2fESnNCVkeHUh?=
ES8 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;rTWM2OD1zMD65JI5O NUXaT3BbW0GQR1XS
PA-1 NGqycIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGqyXGlKSzVyPUGxMlgzKG6P NXjS[Il1W0GQR1XS
Mewo MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jGc2lEPTB;MUGuPVkhdk1? M1jT[nNCVkeHUh?=
HSC-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTF{LkKxJI5O NEnT[mlUSU6JRWK=
H4 NY\GcVJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jSUGlEPTB;MUKuOlchdk1? NGP6[XpUSU6JRWK=
BB65-RCC M1fueGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjJSJlKSzVyPUGyMlczKG6P M3zCVHNCVkeHUh?=
NCI-H1793 Ml\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTF{LkiyJI5O M37sc3NCVkeHUh?=
KARPAS-45 Mmq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLkTWM2OD1zMz61NUBvVQ>? NIjzZ2VUSU6JRWK=
GCT MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi4TWM2OD1zMz62PEBvVQ>? NXjxOJRIW0GQR1XS
EoL-1 NGW4dJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHETWM2OD1zMz65N{BvVQ>? NFu0fnVUSU6JRWK=
LB2241-RCC NEfveVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF2LkCxJI5O NVz6e|JNW0GQR1XS
ES5 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fEdmlEPTB;MUSuO|Qhdk1? Ml3DV2FPT0WU
LOXIMVI Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUL2WZFWUUN3ME2xOE46QSCwTR?= NVXZbJBqW0GQR1XS
COR-L105 NGDT[Y5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rwSmlEPTB;MUWuNFQhdk1? Mk\GV2FPT0WU
P12-ICHIKAWA NH75ToFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnNSFVKSzVyPUG1MlEhdk1? M3rYO3NCVkeHUh?=
CHL-1 MkfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\BTWM2OD1zNT60OUBvVQ>? MlXFV2FPT0WU
VMRC-RCZ M2T5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXK0OXBwUUN3ME2xOU43OyCwTR?= MWnTRW5ITVJ?
HH M2Pmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jZbGlEPTB;MUWuO{BvVQ>? MUnTRW5ITVJ?
NUGC-3 M1;ZVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTF4LkO0JI5O NWXMVWZqW0GQR1XS
EGI-1 NYr1eGdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHJUY5KSzVyPUG2MlQ{KG6P MWPTRW5ITVJ?
OS-RC-2 NX\CN2RbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHhO2tKSzVyPUG2MlQ4KG6P NXuwWXptW0GQR1XS
MOLT-16 NGH6eW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPTOnI6UUN3ME2xO{4yPSCwTR?= MUfTRW5ITVJ?
NCI-H209 NXnrSYpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PHWWlEPTB;MUeuNlkhdk1? NVTIN3piW0GQR1XS
697 NF[ySZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3mwNmlEPTB;MUeuOFMhdk1? MXHTRW5ITVJ?
D-56MG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LrV2lEPTB;MUeuOlkhdk1? MWjTRW5ITVJ?
VA-ES-BJ M2Xp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXzVHh6UUN3ME2xO{45OyCwTR?= NEm5cIpUSU6JRWK=
EW-16 M4rxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzRTWM2OD1zOD6wOEBvVQ>? MlrhV2FPT0WU
HGC-27 M1LzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIiy[5RKSzVyPUG4MlA3KG6P NGrtUVNUSU6JRWK=
ES7 NIS2[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Pod2lEPTB;MUiuNFkhdk1? Mo\iV2FPT0WU
HuH-7 NVziNFhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGW4W4RKSzVyPUG4MlQhdk1? MnPmV2FPT0WU
BCPAP NH[w[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGftU2xKSzVyPUG4MlY2KG6P MV\TRW5ITVJ?
SW1710 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPmbYZSUUN3ME2xPE44OiCwTR?= MUnTRW5ITVJ?
IST-MEL1 NIPIZoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G1dmlEPTB;MUiuO|chdk1? Mn\EV2FPT0WU
SF295 NIj5NGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXz6dXdTUUN3ME2xPE46OyCwTR?= NYL2bVQxW0GQR1XS
RPMI-7951 M2nqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnf4TWM2OD1zOT6yPEBvVQ>? M4TMO3NCVkeHUh?=
SF126 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFu4XnhKSzVyPUG5MlQyKG6P NUHL[4hzW0GQR1XS
GAMG M1\U[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfC[HJKSzVyPUG5MlQ5KG6P MnnKV2FPT0WU
KNS-81-FD M2DsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn3UYxKSzVyPUG5MlU1KG6P NImwVFVUSU6JRWK=
RT-112 NX;yclV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV21R|VvUUN3ME2xPU43PiCwTR?= NGjVRnVUSU6JRWK=
DEL NHTNR3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfm[GFKUUN3ME2yNE41QSCwTR?= NVTXZ4xqW0GQR1XS
CGTH-W-1 NGjSdGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTiSpFiUUN3ME2yNE43OyCwTR?= M2rLTHNCVkeHUh?=
HOS M4jBZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnx[pRKSzVyPUKxMlA3KG6P MYPTRW5ITVJ?
ES4 NFTOVXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfTOm5WUUN3ME2yNU4xQCCwTR?= NV3xepIyW0GQR1XS
RXF393 NUHPNWV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17zb2lEPTB;MkGuOFUhdk1? MkfTV2FPT0WU
NCI-H2030 MnHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;MZ3dKSzVyPUKxMlUzKG6P NGHEOXNUSU6JRWK=
YH-13 M3K0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHJTWM2OD1{MT64PEBvVQ>? NFfCcWNUSU6JRWK=
HT-1080 Ml3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLFbo1KSzVyPUKxMlk{KG6P MYHTRW5ITVJ?
NCI-SNU-1 MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJzLkm1JI5O M1jvU3NCVkeHUh?=
G-402 Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJ{LkG2JI5O NHvVU5FUSU6JRWK=
786-0 M3Szc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2joWGlEPTB;MkKuNlkhdk1? NXuyPGZNW0GQR1XS
ME-180 NH\scIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJ{LkSzJI5O MkXKV2FPT0WU
NB69 MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX0NW9KSzVyPUKyMlU{KG6P MWXTRW5ITVJ?
J-RT3-T3-5 NWjUW|ZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHIVYhKSzVyPUKyMlk3KG6P M3e0dHNCVkeHUh?=
TGBC1TKB Mm\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;1ZoVvUUN3ME2yN{4xPSCwTR?= NX\OTVJ{W0GQR1XS
SW780 NWHGU3dnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH76[phKSzVyPUKzMlE{KG6P M1vCWnNCVkeHUh?=
MG-63 M3HRU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LuemlEPTB;MkOuOFUhdk1? MY\TRW5ITVJ?
BV-173 NGnGUG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrjOFRKSzVyPUKzMlg4KG6P Mke5V2FPT0WU
CAL-51 NHXHTo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTJ|Lki5JI5O NWfsXYJHW0GQR1XS
A375 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnNUoRKSzVyPUKzMlk{KG6P M37HXHNCVkeHUh?=
MEL-HO NHPJWZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJ2LkC0JI5O NH7mZXNUSU6JRWK=
EFO-27 NUj5XoZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17hOWlEPTB;MkSuN|Mhdk1? MlH6V2FPT0WU
Hs-578-T MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7JTWM2OD1{ND61PEBvVQ>? M3m0OnNCVkeHUh?=
NBsusSR M3T6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJ2Lk[gcm0> M1LmU3NCVkeHUh?=
CTB-1 MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTJ2Lk[3JI5O NV34VlQ{W0GQR1XS
FTC-133 NULJNVlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJ3LkGgcm0> NIm0SItUSU6JRWK=
MOLT-4 M2jtdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTJ3LkGyJI5O MnO5V2FPT0WU
HO-1-N-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[0TWM2OD1{NT6xOUBvVQ>? MmrVV2FPT0WU
ES3 NFjq[olIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3Z[VNKSzVyPUK1MlIzKG6P M2TjOXNCVkeHUh?=
TI-73 NF;sWnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rEe2lEPTB;MkWuNlghdk1? M3rwenNCVkeHUh?=
MPP-89 M1n5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEm3OlRKSzVyPUK1MlMzKG6P MVPTRW5ITVJ?
KYSE-150 NV7mcoQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1T4fWlEPTB;MkWuPFkhdk1? Mo\mV2FPT0WU
LXF-289 NI\Fd2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVGyb212UUN3ME2yOk4xPCCwTR?= MYLTRW5ITVJ?
SK-LU-1 MlfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfMOFJHUUN3ME2yOk4yPyCwTR?= M{nzUHNCVkeHUh?=
HOP-92 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLLTWM2OD1{Nj60PEBvVQ>? NYrJd28{W0GQR1XS
HuO9 NUi5UHdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXBTWM2OD1{Nj63OkBvVQ>? M{jUT3NCVkeHUh?=
SW962 NFj3dZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfFS4ZwUUN3ME2yOk44PiCwTR?= MXnTRW5ITVJ?
RS4-11 M4jSb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[0NYVKSzVyPUK2MlkyKG6P NG\LTYRUSU6JRWK=
NCI-H292 MlvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJ5IH7N NHfyeHdUSU6JRWK=
DB MoK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUP2cYgzUUN3ME2yO{4{PiCwTR?= NGjXToFUSU6JRWK=
SW1088 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJ6LkK5JI5O M4fUNHNCVkeHUh?=
A204 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHMb4RKSzVyPUK4MlQ4KG6P NIfKSm5USU6JRWK=
A3-KAW NF\vbHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ewXGlEPTB;MkiuOlQhdk1? M1rBNXNCVkeHUh?=
MV-4-11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGq2[IhKSzVyPUK4Mlchdk1? Mm\BV2FPT0WU
ES1 NWXm[lYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi3OmNyUUN3ME2yPE45PCCwTR?= MmDKV2FPT0WU
ONS-76 MnLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vBfWlEPTB;MkmuNFUhdk1? MWDTRW5ITVJ?
D-263MG NH;SfmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmW5TWM2OD1{OT6zOUBvVQ>? NX3FV4g4W0GQR1XS
U-2-OS NFv3Zm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkW1TWM2OD1{OT61JI5O NYHTZXpCW0GQR1XS
T98G NVLxR|d5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljSTWM2OD1{OT64PEBvVQ>? MXXTRW5ITVJ?
GI-ME-N NEG5d5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fzXmlEPTB;MkmuPVEhdk1? NU\ENmY3W0GQR1XS
BHT-101 NVLmSllnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTNyLkC1JI5O MUTTRW5ITVJ?
NOS-1 NGj0ZlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jjSmlEPTB;M{CuNVIhdk1? NFexT5VUSU6JRWK=
AsPC-1 NH\vSXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4K2TmlEPTB;M{CuNkBvVQ>? NYLxTohqW0GQR1XS
QIMR-WIL M4P5eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonOTWM2OD1|MD62JI5O M4L3XXNCVkeHUh?=
JVM-3 M3TZfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPhTWM2OD1|MD64N{BvVQ>? MUPTRW5ITVJ?
KU-19-19 NGLEfHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjDTWM2OD1|MT6xN{BvVQ>? NVX2Wo1LW0GQR1XS
OVCAR-8 NX3aWW9uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP6[GtKSzVyPUOxMlI3KG6P MnLPV2FPT0WU
BEN M2\2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTNzLk[zJI5O MkDjV2FPT0WU
BE-13 NIjxV|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTNzLkiyJI5O MonEV2FPT0WU
EW-18 NGK2eY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF65UotKSzVyPUOxMlg3KG6P NHLzcIVUSU6JRWK=
ECC10 M1zZVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjQTWM2OD1|MT65OUBvVQ>? NXvJWnFzW0GQR1XS
CTV-1 Mln5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLYTWM2OD1|Mj64NkBvVQ>? MWfTRW5ITVJ?
COLO-800 MofYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTN{LkmyJI5O NF[3SlVUSU6JRWK=
A2058 NYTlT5RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;QTWM2OD1|Mz6yOUBvVQ>? MoDDV2FPT0WU
VM-CUB-1 NI\Vdo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLjTWM2OD1|Mz60N{BvVQ>? M1XafnNCVkeHUh?=
Ca9-22 NXPMd5B3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXweGxKSzVyPUOzMlU2KG6P MWHTRW5ITVJ?
COLO-684 Moi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfTTllKSzVyPUOzMlU5KG6P MV7TRW5ITVJ?
RPMI-8226 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTN|LkiyJI5O MWjTRW5ITVJ?
SK-NEP-1 NWH5Z2hpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLaTWM2OD1|ND6xOUBvVQ>? NIC4UJFUSU6JRWK=
Becker M3mycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjyTWM2OD1|ND6yNUBvVQ>? M4HlOHNCVkeHUh?=
NCI-H28 NXGxOYlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDZOXpKSzVyPUO0MlQ1KG6P M4DIenNCVkeHUh?=
CAL-120 NFvRT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjDdo9CUUN3ME2zOE44OiCwTR?= MX3TRW5ITVJ?
MDA-MB-157 NUHKfo44T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mni2TWM2OD1|NT60NUBvVQ>? MnvwV2FPT0WU
OVCAR-5 M2jHRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPodFA2UUN3ME2zOU41PyCwTR?= Mlm5V2FPT0WU
LAMA-84 M3\VS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrMSodKSzVyPUO1Mlg4KG6P NFjnWpdUSU6JRWK=
CAKI-1 MlKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzNTWM2OD1|Nj60N{BvVQ>? MkT2V2FPT0WU
Daoy M3jQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHNSYdqUUN3ME2zOk44KG6P MnjVV2FPT0WU
CAL-62 NG\a[ppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmOwTWM2OD1|Nj64OkBvVQ>? NIntc|hUSU6JRWK=
8-MG-BA M17ocmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHXTWM2OD1|Nz6yOUBvVQ>? NES5XJJUSU6JRWK=
8505C M4TPZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDReXhKSzVyPUO3MlUyKG6P NVrYd3JNW0GQR1XS
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CAL-39 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETjbGdKSzVyPUO3Mlkhdk1? MUXTRW5ITVJ?
MN-60 NWWzOJo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTN5Lkm2JI5O M4\2fnNCVkeHUh?=
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SJSA-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTsTWM2OD1|OD61OEBvVQ>? NFmyZ4FUSU6JRWK=
CAL-12T MmjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LQR2lEPTB;M{iuOkBvVQ>? NFOxW3NUSU6JRWK=
HCC1419 MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTN6LkexJI5O M1[0NnNCVkeHUh?=
CO-314 MmrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTN6Lke0JI5O M1XITnNCVkeHUh?=
LB1047-RCC NG\Id4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3riSmlEPTB;M{iuPFEhdk1? NEPjVGtUSU6JRWK=
A101D NWDqdFZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTN6Lkm3JI5O Mn7zV2FPT0WU
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8305C M{HFdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjzTWM2OD12MT64O{BvVQ>? MVvTRW5ITVJ?
BHY M3j2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTR{LkeyJI5O NWfpPZhxW0GQR1XS
NTERA-S-cl-D1 M1Hu[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTR|IH7N MnnhV2FPT0WU
T-24 NYn6VFR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTNUpNKUUN3ME20N{45OyCwTR?= M3W5SHNCVkeHUh?=
EPLC-272H Mn;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzLTWM2OD12ND6zPUBvVQ>? MnjFV2FPT0WU
PSN1 NVX4RYM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzBfWJKSzVyPUS0MlQhdk1? MmDsV2FPT0WU
NCI-H2452 NVv3NZpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTR2LkW4JI5O NGLCWWNUSU6JRWK=
KS-1 Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDkXJdbUUN3ME20OE43PiCwTR?= MmfCV2FPT0WU
HD-MY-Z NHPPT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTR2LkmyJI5O NEju[2xUSU6JRWK=
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NOMO-1 M3;G[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLHW3VKSzVyPUS1Mlg4KG6P M1zxVXNCVkeHUh?=
SK-HEP-1 NHLQUpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTR4LkC0JI5O MYrTRW5ITVJ?
IGR-1 NVS3Vot4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPu[I9uUUN3ME20Ok4yOyCwTR?= MXrTRW5ITVJ?
KYSE-180 Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDpR3RKSzVyPUS2MlE4KG6P MnfWV2FPT0WU
EW-22 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\XW2lEPTB;NE[uNkBvVQ>? M4W1VnNCVkeHUh?=
NCI-H1355 NEnzR3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTR4LkO0JI5O NH;L[W5USU6JRWK=
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PC-14 M1:5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\iTWM2OD12Nj61O{BvVQ>? M2K2TXNCVkeHUh?=
TE-5 NUX6c4w4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zKdGlEPTB;NE[uPFQhdk1? NU\MfngyW0GQR1XS
LB996-RCC MnjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvvTWM2OD12Nz6xPUBvVQ>? NFnxblhUSU6JRWK=
NCI-H1623 NXO4W|l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTR5Lke2JI5O M3HzPHNCVkeHUh?=
NCI-H1155 NHTuSXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTR6LkOyJI5O MVXTRW5ITVJ?
LoVo MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGP1cXVKSzVyPUS4MlQhdk1? NWi5SWpuW0GQR1XS
MCF7 MoXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jDRmlEPTB;NEiuOVghdk1? MVLTRW5ITVJ?
AGS M3;tbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPGPGxlUUN3ME20PE44PyCwTR?= NWTpXoJPW0GQR1XS
PFSK-1 NGLOXlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETRUG1KSzVyPUS5MlA3KG6P MVzTRW5ITVJ?
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COR-L23 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTR7LkG2JI5O NVvuPGhqW0GQR1XS
D-283MED M2Thbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTR7Lk[xJI5O NHfnVlhUSU6JRWK=
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SW620 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TLW2lEPTB;NUCuN|Yhdk1? M12wRXNCVkeHUh?=
KYSE-140 M3zRSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;GOWlEPTB;NUCuOVUhdk1? M{\CWHNCVkeHUh?=
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MHH-ESS-1 MmHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\rVGlEPTB;NUGuPVUhdk1? NXHocYs5W0GQR1XS
D-423MG M{e1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml65TWM2OD13Mj6wPEBvVQ>? NFLVN2NUSU6JRWK=
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RPMI-2650 M3Xj[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknDTWM2OD13Mj62PUBvVQ>? MlK0V2FPT0WU
GR-ST MlP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zudmlEPTB;NUKuPFchdk1? MVnTRW5ITVJ?
YKG-1 MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTV|IH7N MlHmV2FPT0WU
SK-MES-1 MkTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTV|LkK2JI5O MYDTRW5ITVJ?
HLE MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TJWGlEPTB;NUOuOFchdk1? MYPTRW5ITVJ?
RVH-421 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnW[FBmUUN3ME21N{43PyCwTR?= NEXuO5NUSU6JRWK=
C32 M{\iUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTV|LkizJI5O MojRV2FPT0WU
GB-1 MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXpZ2xnUUN3ME21OE4zKG6P MnfUV2FPT0WU
SNB75 NXe4NmJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XqUGlEPTB;NUSuNlYhdk1? MkLxV2FPT0WU
EM-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17neGlEPTB;NUSuOEBvVQ>? MXvTRW5ITVJ?
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NKM-1 MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HoVmlEPTB;NUSuPFEhdk1? MoD0V2FPT0WU
NCI-H2405 NV32RZd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXQTWM2OD13ND64PEBvVQ>? NULCZoRXW0GQR1XS
KYSE-450 NHT4dplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHuTWM2OD13NT6xOkBvVQ>? MWXTRW5ITVJ?
A704 M4fjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HsRWlEPTB;NUWuOVkhdk1? NUDHeVdpW0GQR1XS
HAL-01 NXPwOHBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnGUGlKSzVyPUW1Mlg{KG6P M2LQ[HNCVkeHUh?=
TE-11 NH7I[FZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1qwemlEPTB;NUWuPVkhdk1? MXfTRW5ITVJ?
DOK NXXpSnJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHke45SUUN3ME21Ok4xOiCwTR?= Mle1V2FPT0WU
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MC116 MmDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fheGlEPTB;NUeuPEBvVQ>? M2rhV3NCVkeHUh?=
PANC-08-13 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnQd45KSzVyPUW4MlAyKG6P M4CzOnNCVkeHUh?=
KE-37 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;ZUGpKSzVyPUW4Mlc4KG6P NETyRoJUSU6JRWK=
KYSE-410 NVHpdW5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHvcYtKSzVyPUW5MlQ4KG6P NUTNdos3W0GQR1XS
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M14 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTZyLkC0JI5O NIPqdGxUSU6JRWK=
GI-1 M4LTVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jL[WlEPTB;NkCuN{BvVQ>? NWfL[3dNW0GQR1XS
ML-2 MnLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TFS2lEPTB;NkCuOlIhdk1? Moi4V2FPT0WU
BFTC-905 MnfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnufVZKSzVyPU[wMlY2KG6P MWrTRW5ITVJ?
DMS-273 M{PXZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGS3OHdKSzVyPU[wMlg4KG6P MkDaV2FPT0WU
MDA-MB-361 MoDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXsO5BKSzVyPU[xJI5O M1jRc3NCVkeHUh?=
MSTO-211H NHLBNXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\aTWM2OD14Mz61NUBvVQ>? MmnEV2FPT0WU
MEG-01 NV7MW4llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\STWM2OD14Mz61NkBvVQ>? NGLJW3FUSU6JRWK=
M059J NGLoeWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO5Z|hKSzVyPU[zMlU5KG6P NYjubVlCW0GQR1XS
LN-405 NGrjXWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTZ|Lki1JI5O NYnENVl2W0GQR1XS
NCI-H1581 NEHhc5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\xXGlEPTB;NkSuNFMhdk1? NUfpNGlHW0GQR1XS
TCCSUP NWTKe5NkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfacGZKSzVyPU[0MlU{KG6P M3;PZ3NCVkeHUh?=
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KYSE-510 NGSwc2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{W1fGlEPTB;NkWuO|Uhdk1? M4TzOXNCVkeHUh?=
NCI-H1792 MmjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\YV4dWUUN3ME22Ok4yPSCwTR?= NVmwTZV4W0GQR1XS
SW13 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTZ4LkWgcm0> NGL2Z|NUSU6JRWK=
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EFM-19 MlnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TqU2lEPTB;NkeuOUBvVQ>? MlS2V2FPT0WU
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T47D MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTZ5Lki3JI5O M3j5UXNCVkeHUh?=
SNU-423 NGqzbXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHzfY9KSzVyPU[3Mlk5KG6P MY\TRW5ITVJ?
WM-115 Mn3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDr[WlKSzVyPU[4MlE1KG6P MXnTRW5ITVJ?
CaR-1 NFj0OJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvNfoVKSzVyPU[4MlI2KG6P NHrobGtUSU6JRWK=
KU812 NHHmbIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi5clBZUUN3ME22PE43QSCwTR?= MVvTRW5ITVJ?
AM-38 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHRW|RKSzVyPU[5MlMyKG6P M2K2[nNCVkeHUh?=
KOSC-2 NG\qTnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TZdWlEPTB;NkmuPVchdk1? M4nZcHNCVkeHUh?=
MC-IXC NHnNNZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrpUnhlUUN3ME23NE4xQCCwTR?= NUXCSFVHW0GQR1XS
SCC-4 MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTdzLkO4JI5O M2HnW3NCVkeHUh?=
Calu-3 NVfhfWJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnyzTWM2OD15MT65PEBvVQ>? NUHLfpo3W0GQR1XS
RPMI-8866 M4raTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;WTWM2OD15Mj64NkBvVQ>? M{\ocnNCVkeHUh?=
OVCAR-4 M2qyfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nmNWlEPTB;N{OuN|Yhdk1? NGDOfnlUSU6JRWK=
OAW-42 MnTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rT[GlEPTB;N{OuN|khdk1? MoXjV2FPT0WU
ATN-1 M1PLfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1SwV2lEPTB;N{OuPFchdk1? Ml;6V2FPT0WU
CHP-212 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXUTWM2OD15ND65OUBvVQ>? NEDCSI5USU6JRWK=
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A498 NGXZTplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\NNmlEPTB;N{WuNVUhdk1? M{XJW3NCVkeHUh?=
SH-4 NUO1N4l4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2L5dGlEPTB;N{WuNlEhdk1? NYL6WmVMW0GQR1XS
SNU-449 MknvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTd3Lke5JI5O M3PVNHNCVkeHUh?=
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PANC-03-27 NIrHdWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\sSmdKSzVyPUe2MlI2KG6P M1LmfXNCVkeHUh?=
S-117 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;i[5ZmUUN3ME23Ok4zPyCwTR?= M1LkVXNCVkeHUh?=
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LK-2 MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDkVY5KSzVyPUe3MlA2KG6P M4nzcXNCVkeHUh?=
CP50-MEL-B Mo[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLQNYhvUUN3ME23O{41KG6P NUXGNnN[W0GQR1XS
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LU-65 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDlV2k4UUN3ME2xMlYzOjR7IN88US=> NUfLcFhVW0GQR1XS
NCI-H1304 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLwR3NKSzVyPUGuOlU1QThizszN NWHvToNbW0GQR1XS
KARPAS-299 NXmzOGZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\1TWM2OD1zLke5OFc6KM7:TR?= MXTTRW5ITVJ?
NCI-H358 MnnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ntOGlEPTB;MT65OVUxOyEQvF2= NIXzcW5USU6JRWK=
OAW-28 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3WU|JKSzVyPUKuNFY6OTlizszN MVHTRW5ITVJ?
C8166 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LweWlEPTB;Mj62N|M6OiEQvF2= NWDHT4NbW0GQR1XS
COLO-678 NYjWXldoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPZNXNKSzVyPUKuPFM4PjhizszN NWTFfldGW0GQR1XS
SK-N-DZ NWWxZWx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrjXWdvUUN3ME2yMlg3OzhzIN88US=> NYLXS2ozW0GQR1XS
NCI-H82 NILUfmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJwOUCzOlkh|ryP MXXTRW5ITVJ?
JVM-2 NUfDRZlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fSO2lEPTB;Mz6wN|E5QCEQvF2= MnT1V2FPT0WU
SW1116 Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnJbpN6UUN3ME2zMlA2PDFzIN88US=> MmTTV2FPT0WU
MDA-MB-453 MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TnOGlEPTB;Mz6xNFQ{QSEQvF2= NUn5OGd5W0GQR1XS
Calu-6 M2PnOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHThT3NKSzVyPUOuNVk6PyEQvF2= NYL0[oJCW0GQR1XS
SHP-77 M33ScWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXK[FJKSzVyPUOuOVI5KM7:TR?= NWfNVphGW0GQR1XS
Capan-2 MmLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvXNG9KSzVyPUSuN|I2QDFizszN MUPTRW5ITVJ?
SW948 M1XKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:4TWM2OD12Lke0O|c6KM7:TR?= NYG3ZXNSW0GQR1XS
HDLM-2 NYLXTGs1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTVwMEe3NlUh|ryP MmnVV2FPT0WU
LAN-6 M2[2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTZwMkG0PVUh|ryP MkS2V2FPT0WU
LU-135 MlvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrQOWtKSzVyPU[uOFMxPzdizszN MnPhV2FPT0WU
T84 NUHXU|YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfMWJdKSzVyPU[uPVg3PCEQvF2= MlnDV2FPT0WU
CAPAN-1 NVP0UZNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mny0TWM2OD15Lk[yNlM{KM7:TR?= MlXCV2FPT0WU
SW1417 NHLPTZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTdwOUG3N|Eh|ryP MlzIV2FPT0WU
BALL-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnOyTWM2OD16LkWwOFA6KM7:TR?= MWPTRW5ITVJ?
HT-29 NGPpbW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTlwMEe1PVkh|ryP NX3HPVlWW0GQR1XS
C3A MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPPTWM2OD17Lki4N|k1KM7:TR?= MXTTRW5ITVJ?
NCI-H1993 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvrTWM2OD1zMD61NFgyKM7:TR?= NInTe21USU6JRWK=
SK-MEL-1 NXK1VlZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnWdXY2UUN3ME2xNU43Ojh7IN88US=> MY\TRW5ITVJ?
DU-145 NXPFdJVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkL2TWM2OD1zND61NFUzKM7:TR?= MofHV2FPT0WU
KP-N-YN MnvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTF2LkWxNFMh|ryP NHTkTnJUSU6JRWK=
CCRF-CEM M1vkbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInJRXVKSzVyPUG0Mlc5ODlizszN MlXsV2FPT0WU
ZR-75-30 NUT4RVVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O5UmlEPTB;MU[uN|MxOyEQvF2= MkDFV2FPT0WU
A673 M2C2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJyLkW1NFch|ryP MWTTRW5ITVJ?
K-562 NF\Bb5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFy3VlVKSzVyPUK4MlQyQDNizszN NETaTotUSU6JRWK=

... Click to View More Cell Line Experimental Data

体内研究 BEZ235诱导肿瘤(69%)消退,而对体重增加没有统计学上显著的作用。总之,这些初步的体内功效研究结果表明,BEZ235单一口服给药时能够阻断疾病的发展,与其他抗癌药结合使用时能够增强疗效。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[2]

+ 展开

体外蛋白激酶,PI3K,和mTOR实验:

PI3Kα, β, δ蛋白都由与p110全长蛋白相接的p85 N端的iSH2域组成,只是PI3Kα没有最后的20个氨基酸。PI3Kγ由p110全长蛋白去掉前144个氨基酸产生而来。所有PI3K蛋白在羧基末端加组氨酸标签便于纯化,然后克隆到pBlue-Bac4.5 (用于α, β,和δ亚型) 或者pVL1393 (用于γ 亚型) 质粒中。转染BaculoGold WT基因组DNA的不同的载体按说明书推荐的方法生产各自重组体杆状病毒及重组蛋白。使用激酶发光检测试剂盒测定BEZ235 (NVP-BEZ235)作用于PI3K的活力。在384孔板上进行激酶实验。在每个孔中加入50 nl的测试项目(溶在90%DMSO中)和5ul的反应buffer,反应buffer包含10 μg/ml PI基质 (l-α-磷脂酰肌醇; 由Avanti Polar Lipids提供;预备在3%辛基葡萄糖苷中),然后加入PI3K 蛋白(p110α, p110β, p110δ,和p110γ分别为10, 25, 10,和150 nM)。加入预备在反应buffer中的5 ul 1 µM 的ATP反应开始,反应进行60分钟 (测p110α, p110β, p110δ)或者120分钟(测p110γ),随后加入10ul的荧光激酶buffer终止反应。数据用Synergy 2 阅读器阅读用于荧光测试。
细胞实验:

[1]

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  • Cell lines: HCT116, DLD-1, SW480
  • Concentrations: 0-1 μM
  • Incubation Time: 48小时
  • Method:

    HCT116 (PIK3CA突变型; 激酶域在H1047R), DLD-1 (PIK3CA突变型;螺旋域在E545K), SW480 (PIK3CA 野生型)人类CRC细胞系,同基因型的DLD-1 PIK3CA突变和野生型细胞培养在含10%FBS和1×青霉素/链霉素的培养基中。细胞按不同的初始密度加入(HCT116: 3000个细胞/每孔, DLD-1: 5500个细胞/每孔, SW480: 4500个细胞/每孔, DLD-1 PIK3CA突变型: 7000个细胞/每孔, DLD-1 PIK3CA野生型: 9000个细胞/每孔),用来计算不同的生长动力学。16个小时后,细胞加入浓度越来越高的BEZ235中进行温育,含有药物的培养基24小时更换一次。根据产品说明书,加入细胞16小时和药物处理48小时,使用单溶液细胞增殖检测试剂盒以比色法检测细胞活力。与没有用药物处理正在生长的细胞相比,药物处理的细胞的活力也逐渐趋于正常化。使用GraphPad Prism 5软件用4个参数的回归曲线计算IC50值。用于western blot 分析,细胞用0 nM 或者最高抑制剂量(500 nM) BEZ235处理 2, 6, 24, 或者48 小时。


    (Only for Reference)
动物实验:

[2]

+ 展开
  • Animal Models: 雌性Harlan无胸腺裸鼠
  • Formulation: NMP/聚乙二醇300(10/90,v/v)
  • Dosages: 45 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
NMP+polyethylene glycol 300 (10+90, v+v)
30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 469.55
化学式

C30H23N5O

CAS号 915019-65-7
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03373903 Active not recruiting Respiratory Tract Infections Restorbio Inc. November 15 2017 Phase 2
NCT03373903 Active not recruiting Respiratory Tract Infections Restorbio Inc. November 15 2017 Phase 2
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • 回答:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

相关PI3K产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID