Dactolisib (BEZ235, NVP-BEZ235)

目录号：S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3K 和 mTOR 抑制剂，在无细胞试验中，抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR，IC50 为 21 nM，而对 Akt 和 PDK1 的抑制作用很弱。Phase 2。

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客户购买Selleck的此次产品后发表的文献88篇：

客户使用该产品的11个实验数据：

  • Level of phospho-proteins in RTK and PI3K–Akt–mTOR pathways in treated tumours, detected with western blot.

    Nature, 2017, 728-732. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • (B) The effects of AZD2014, BEZ235, lapatinib, LEE011, pazopanib on PI3K/AKT signaling in sarcoma PDC line were determined by immunoblotting analysis. Cells were treated with 1 μM of the indicated drugs for 72 h.

    Transl Oncol, 2016, 9(3):197-202. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    The effects of LY294002, rapamycin and NVP-BEZ235 on activation of PI3K-Akt-mTOR pathway in hepatocytes. (a) The mRNA expression (PI3K, Akt, mTOR, raptor) by Real-Time PCR, (b) protein expression (PI3K, Akt, mTOR, S6K) by ELISA kits; (c) protein expression of S6K and P-S6K by western blotting. The different letters indicated significant differences (P <0.05). LY = LY294002; rapa = rapamycin; NVP = NVP-BEZ235.

    Animal, 2016, 10(8):1319-27. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3K 和 mTOR 抑制剂，在无细胞试验中，抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR，IC50 为 21 nM，而对 Akt 和 PDK1 的抑制作用很弱。Phase 2。
靶点
p110α [1]
(Cell-free assay)		 p110γ [1]
(Cell-free assay)		 mTOR (p70S6K) [1]
(Cell-free assay)		 p110δ [1]
(Cell-free assay)		 ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
体外研究

BEZ235显著降低mTOR活化的激酶p70S6K的磷酸化水平。BEZ235导致S235/S236P-RPS6水平减少，IC50为6.5 nM。BEZ235抗mTOR的活性使用生化mTOR K-LISA试验测定，IC50为20.7 nM。BEZ235对其β旁系同源物的活性稍弱，IC50为75 nM。在人肿瘤细胞中，PI3K/Akt/mTOR通路经常被组成性活化。BEZ235阻断PI3K和mTOR激酶活性，通过结合于这些酶的ATP结合槽发挥作用。用逐渐增加浓度BEZ235处理PTEN-null细胞系PC3M和U87MG时，导致细胞增殖剂量依赖性减少，平均GI50为10-12 nM。[1] BEZ235是一种mTORC1/2催化抑制剂。[2]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei NXr4U2tZSW62aX3pZ5Jw[mmjbDDBd5NigQ>? MXKxPEBp NYjJcoplTE2VTx?= NHHCPHlCdnSrdIL5dIFvd3OxbXHsJIFkfGm4aYT5JJdqfGhiRVO1NEBw\iByLkCwNlUh|ryP MlTQNlQ5ODV7NE[=
MCF7 NWTYdJI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVKwMlAyNTFyMDFOwG0> NIe4SJg1QCCq M160N2ROW09? NID6fI9KSzVyPUCuO|Mh|ryP NEHBUXAzOzh5MUmwOC=>
HCT116 NXPRXXlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzDNE4xOS1zMECg{txO NFfuPVc1QCCq NVm1[ZdpTE2VTx?= Mnv0TWM2OD1zLkG2JO69VQ>? MV[yN|g4OTlyNB?=
U87MG M4\m[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITIOHoxNjBzLUGwNEDPxE1? NFK3UFc1QCCq MWLEUXNQ M1TZXGlEPTB;MT6zNkDPxE1? NGLRWoszOzh5MUmwOC=>
HBC4 NXzwTmpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HzXlAvODFvMUCwJO69VQ>? MUW0PEBp NFTVR5FNd2diR1m1NF0uQC54MTDN NInr[4ozOjN|NkK0Oi=>
BSY1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfMUYwxNjBzLUGwNEDPxE1? MWm0PEBp M3vIZ2xw\yCJSUWwQU05NjR6IF2= MkjGNlI{OzZ{NE[=
HBC5 NHn2R5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXSyU2ZHOC5yMT2xNFAh|ryP NXL2NodYPDhiaB?= NXfuTmZwVG:pIFfJOVA:NTdwOEegUS=> NYSwXoQxOjJ|M{[yOFY>
MCF7 M2[4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HxeVAvODFvMUCwJO69VQ>? NYHKT4lzPDhiaB?= NXS2XG9pVG:pIFfJOVA:NThwMU[gUS=> Mn\BNlI{OzZ{NE[=
MDA-MB-231 NXTufXFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfjd5ltOC5yMT2xNFAh|ryP NV:4c3BQPDhiaB?= NUfOW3R7VG:pIFfJOVA:NThwMEmgUS=> NEXWd4wzOjN|NkK0Oi=>
U251 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPScogxNjBzLUGwNEDPxE1? M3vYSVQ5KGh? M4L3OGxw\yCJSUWwQU04NjZ4IF2= MXyyNlM{PjJ2Nh?=
SF268 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13y[lAvODFvMUCwJO69VQ>? NYjTV4tIPDhiaB?= NYfhephPVG:pIFfJOVA:NTdwOUKgUS=> NF3tU4kzOjN|NkK0Oi=>
SF295 MljWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3iNE4xOS1zMECg{txO M2\xZVQ5KGh? MUXMc4chT0l3ME2tPE4{OSCP NXf4VJo2OjJ|M{[yOFY>
SF539 M3npVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrJfHcxNjBzLUGwNEDPxE1? MoL0OFghcA>? MmPIUI9oKEeLNUC9MVgvPTliTR?= M2m4XFIzOzN4MkS2
SNB75 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWSwMlAyNTFyMDFOwG0> MXi0PEBp MVnMc4chT0l3ME2tPE42QCCP NWnNU|hQOjJ|M{[yOFY>
SNB78 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPn[4xKOC5yMT2xNFAh|ryP MXu0PEBp M1rNTGxw\yCJSUWwQU05NjZ3IF2= MkXxNlI{OzZ{NE[=
HCC2998 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HBfVAvODFvMUCwJO69VQ>? NUi2TXFDPDhiaB?= M1\Yd2xw\yCJSUWwQU05NjB3IF2= NGfaOFEzOjN|NkK0Oi=>
KM12 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlSwNE4xOS1zMECg{txO MojtOFghcA>? NWjBW5JtVG:pIFfJOVA:NTdwNUSgUS=> M2jBN|IzOzN4MkS2
HT-29 NGixS4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{i2W|AvODFvMUCwJO69VQ>? NFPye3U1QCCq NXv4RYF6VG:pIFfJOVA:NTdwN{WgUS=> Ml3xNlI{OzZ{NE[=
HCT15 NYHjXHN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXGwMlAyNTFyMDFOwG0> NXH1b2dWPDhiaB?= MUjMc4chT0l3ME2tPE4xOyCP M3nLUFIzOzN4MkS2
HCT116 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj4TnlROC5yMT2xNFAh|ryP Ml;2OFghcA>? MVvMc4chT0l3ME2tO{43OSCP M{SwdlIzOzN4MkS2
NCI-H23 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUiwMlAyNTFyMDFOwG0> NYTKWG11PDhiaB?= MWXMc4chT0l3ME2tO{43PCCP NUXrc4N5OjJ|M{[yOFY>
NCI-H226 Ml7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYiwMlAyNTFyMDFOwG0> M4jScFQ5KGh? NWnNbJhKVG:pIFfJOVA:NThwNESgUS=> NVT4TVJYOjJ|M{[yOFY>
NCI-H522 NEXhTmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnq5NE4xOS1zMECg{txO MXK0PEBp MXrMc4chT0l3ME2tPE41PSCP Mn3LNlI{OzZ{NE[=
NCI-H438 M{D0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDwW|kxNjBzLUGwNEDPxE1? NGH4NIQ1QCCq MlztUI9oKEeLNUC9MVgvOTFiTR?= NGj2PHozOjN|NkK0Oi=>
A549 NXvQTnp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnVc3QxNjBzLUGwNEDPxE1? NGrDRZo1QCCq MmnPUI9oKEeLNUC9MVgvODdiTR?= NXjaTW5UOjJ|M{[yOFY>
DMS273 NYTIW4VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfCUFdjOC5yMT2xNFAh|ryP Mlz3OFghcA>? NH3hPGFNd2diR1m1NF0uPy56MDDN NH;NTFEzOjN|NkK0Oi=>
DMS114 NIn4dnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\nSZoxNjBzLUGwNEDPxE1? NVjRZ2tsPDhiaB?= NXXhSYFvVG:pIFfJOVA:NThwM{mgUS=> NVnz[ZV{OjJ|M{[yOFY>
LOXIMVI NUXpcIwzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP5NE4xOS1zMECg{txO M1;OXlQ5KGh? MnTlUI9oKEeLNUC9MVgvPjZiTR?= MlzQNlI{OzZ{NE[=
OVCAR3 M1fxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXiwMlAyNTFyMDFOwG0> Mom1OFghcA>? MkLJUI9oKEeLNUC9MVgvOTdiTR?= NGjBNnczOjN|NkK0Oi=>
OVCAR4 NH3VZWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljpNE4xOS1zMECg{txO M4Xvc|Q5KGh? NH\Ic5RNd2diR1m1NF0uQC53ODDN MlToNlI{OzZ{NE[=
OVCAR5 NEW1[o1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfoT3pIOC5yMT2xNFAh|ryP NY\ieJVOPDhiaB?= MnzjUI9oKEeLNUC9MVcvPTdiTR?= NV3xOYNuOjJ|M{[yOFY>
OVCAR8 NFvkXYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLTRll4OC5yMT2xNFAh|ryP M{TZN|Q5KGh? MknIUI9oKEeLNUC9MVcvQDRiTR?= NWjNWXFWOjJ|M{[yOFY>
SKOV3 M1fPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\jZ|AvODFvMUCwJO69VQ>? NYjXWlZnPDhiaB?= M1TvOWxw\yCJSUWwQU05NjRzIF2= Mm\XNlI{OzZ{NE[=
RXF631L MmXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjMNE4xOS1zMECg{txO M2ryRlQ5KGh? NUPjdYtLVG:pIFfJOVA:NThwMkGgUS=> MU[yNlM{PjJ2Nh?=
ACHN NEfENlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYqwMlAyNTFyMDFOwG0> NHLGcYg1QCCq NHTpSI5Nd2diR1m1NF0uPy57NTDN NWXlRXlqOjJ|M{[yOFY>
St-4 MkfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[xNI5wOC5yMT2xNFAh|ryP NIPXe481QCCq NUnDdXFZVG:pIFfJOVA:NTdwNEegUS=> MXOyNlM{PjJ2Nh?=
MKN1 M2i2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmf1NE4xOS1zMECg{txO M3LMe|Q5KGh? NYnCTnlVVG:pIFfJOVA:NThwNEGgUS=> M{X1bFIzOzN4MkS2
MKN7 MlzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly0NE4xOS1zMECg{txO Ml\TOFghcA>? NXHuSoFyVG:pIFfJOVA:NTdwNkigUS=> Mo\QNlI{OzZ{NE[=
MKN28 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvuNE4xOS1zMECg{txO MlfkOFghcA>? NULPXIJHVG:pIFfJOVA:NTdwMEegUS=> NWfT[W5JOjJ|M{[yOFY>
MKN45 Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHCWmcxNjBzLUGwNEDPxE1? NYr1SZplPDhiaB?= Mm\zUI9oKEeLNUC9MVgvOzRiTR?= NETRPFMzOjN|NkK0Oi=>
MKN74 M{PkZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2KwfFAvODFvMUCwJO69VQ>? Ml\WOFghcA>? NF7xPGVNd2diR1m1NF0uPy52MjDN MYKyNlM{PjJ2Nh?=
DU145 M1XoVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLZWncxNjBzLUGwNEDPxE1? NYO3NplrPDhiaB?= NFfLR2pNd2diR1m1NF0uQC5zNjDN MlHWNlI{OzZ{NE[=
PC3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF[1OGUxNjBzLUGwNEDPxE1? NGW2e|c1QCCq NXTBclY6VG:pIFfJOVA:NThwNk[gUS=> M4LtW|IzOzN4MkS2
Trypanosoma brucei brucei M2q3RWZ2dmO2aX;uJGF{e2G7 MWCyNFAhdk1? MWKxNkBp NFXGdoxFVVOR M325TmRm[3KnYYPlJIlvKHCqb4PwbI91cWS7bDDpco9{cXSxbDDwbI9{eGijdHWgcIV3\Wx? NV6wWotnOjR6MEW5OFY>
Trypanosoma brucei brucei Mn\rSpVv[3Srb36gRZN{[Xl? MUGxPEBp M1nBSWROW09? MmD1TY5pcWKrdHnvckBw\iC{ZXPldJRwei2vZXTpZZRm\CCnbnTvZ5l1d3OrczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiC2cnHud4ZmenKrbjD1dJRic2V? NHLLWYIzPDhyNUm0Oi=>
Trypanosoma brucei brucei MV3GeY5kfGmxbjDBd5NigQ>? NGC3RmMzODBibl2= NGGxXZAyOiCq M2LjS2ROW09? MYrF[oZm[3Rib36gd5BpcW6pb335cIVqdiCuZY\lcC=> MmL6NlQ5ODV7NE[=
Trypanosoma brucei brucei MV\GeY5kfGmxbjDBd5NigQ>? Mo\yNlAxKG6P MV6xNkBp M4XnRmROW09? MYPF[oZm[3Rib36gdIhwe3CqYYTp[Jlt[2ixbHnu[UBt\X[nbB?= M2PaeVI1QDB3OUS2
UM-UC-3 NGjmWXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILLUVBKSzVyPUOxOUBxVQ>? NGjBO3RUSU6JRWK=
SBC-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnNSpFwUUN3ME23OFIheE1? MmSyV2FPT0WU
MKN1 NWDydGRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnH[W9tUUN3ME2yMlghdk1? MUDTRW5ITVJ?
NCI-H720 NWfSbIgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfiTWM2OD1|LkW3JI5O NXrDbo0xW0GQR1XS
BFTC-909 Mmm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrLS3pKSzVyPUOuO|Ehdk1? MUDTRW5ITVJ?
BPH-1 NHjXZpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTRwN{[gcm0> M3v6U3NCVkeHUh?=
PC-3 M1\Zemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHWzV2pKSzVyPUWuNFkhdk1? NVvMbotYW0GQR1XS
AN3-CA MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HRUGlEPTB;NT61OkBvVQ>? MlzBV2FPT0WU
HN Moq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTVwOU[gcm0> MmnRV2FPT0WU
HCC2218 NEG4cFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPMVFJKSzVyPU[uOlEhdk1? NYjSWFBzW0GQR1XS
KP-4 MkCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknWTWM2OD15IH7N NV62SXc{W0GQR1XS
LU-139 NVHlbVh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnyVVRKSzVyPUeuO|chdk1? MkLEV2FPT0WU
ETK-1 MknoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTdwOEigcm0> M1LyeXNCVkeHUh?=
Ramos-2G6-4C10 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TYcmlEPTB;OD60PUBvVQ>? M1H2VXNCVkeHUh?=
MHH-PREB-1 NVjyNmxtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvZS5FKSzVyPUmuNVIhdk1? NFuw[IJUSU6JRWK=
DU-4475 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTlwNESgcm0> MVHTRW5ITVJ?
NCI-H1666 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEGwfWJKSzVyPUmuO|Ehdk1? NFLMN2xUSU6JRWK=
CAMA-1 NF;YSolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3i1UmlEPTB;OT64JI5O M1;4OHNCVkeHUh?=
TYK-nu NY\ZfXpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTlwOUSgcm0> MoKyV2FPT0WU
MFE-280 M3nnOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3qzfGlEPTB;OT65PUBvVQ>? NEKzWpdUSU6JRWK=
A549 NE\wT4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS5TnNKSzVyPUGwMlE1KG6P M4\GdXNCVkeHUh?=
769-P MnfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTFyLkS0JI5O NH\iOJBUSU6JRWK=
L-363 NEjFfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvaTWM2OD1zMD62PUBvVQ>? MU\TRW5ITVJ?
ES8 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFyLkmgcm0> NXLmN2ZtW0GQR1XS
PA-1 NHP4TnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIm0WJZKSzVyPUGxMlgzKG6P MljPV2FPT0WU
Mewo NFjFNG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXqd5NKSzVyPUGxMlk6KG6P NX7QZXQ5W0GQR1XS
HSC-3 Ml;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTF{LkKxJI5O NHHq[GtUSU6JRWK=
H4 MofhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF{Lk[3JI5O MnToV2FPT0WU
BB65-RCC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTF{LkeyJI5O MWjTRW5ITVJ?
NCI-H1793 MkP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTkTWM2OD1zMj64NkBvVQ>? NE[2XYdUSU6JRWK=
KARPAS-45 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTF|LkWxJI5O M{\6RnNCVkeHUh?=
GCT M3nmc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnv[WpKSzVyPUGzMlY5KG6P MmLqV2FPT0WU
EoL-1 MoG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTF|LkmzJI5O MkTnV2FPT0WU
LB2241-RCC NIO0cWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnhVVllUUN3ME2xOE4xOSCwTR?= NFrPWnRUSU6JRWK=
ES5 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mne0TWM2OD1zND63OEBvVQ>? MUHTRW5ITVJ?
LOXIMVI NXvsTJg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnPTWM2OD1zND65PUBvVQ>? MoL5V2FPT0WU
COR-L105 NF\G[4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7QTWM2OD1zNT6wOEBvVQ>? NHvLTmZUSU6JRWK=
P12-ICHIKAWA MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvjTWM2OD1zNT6xJI5O NUi0cHVyW0GQR1XS
CHL-1 M{D2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXoTWM2OD1zNT60OUBvVQ>? NYi2XGh{W0GQR1XS
VMRC-RCZ M1XvV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTF3Lk[zJI5O MVzTRW5ITVJ?
HH NUnhWm1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojGTWM2OD1zNT63JI5O Mmn4V2FPT0WU
NUGC-3 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3LVHNmUUN3ME2xOk4{PCCwTR?= MVHTRW5ITVJ?
EGI-1 NWfkbYFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTF4LkSzJI5O MnzhV2FPT0WU
OS-RC-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXkZYVKSzVyPUG2MlQ4KG6P NWfxOlhjW0GQR1XS
MOLT-16 NVLn[WhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vXUWlEPTB;MUeuNVUhdk1? NV;GUnllW0GQR1XS
NCI-H209 NGrTeY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjqTWM2OD1zNz6yPUBvVQ>? MoXJV2FPT0WU
697 NHyyWnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTF5LkSzJI5O NEXZO|dUSU6JRWK=
D-56MG Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLZUo5PUUN3ME2xO{43QSCwTR?= M{\sNXNCVkeHUh?=
VA-ES-BJ NIP1dYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLEdnJKSzVyPUG3Mlg{KG6P M2nD[3NCVkeHUh?=
EW-16 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHGTWM2OD1zOD6wOEBvVQ>? M1XkRXNCVkeHUh?=
HGC-27 NYPIc4M3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\ZZ5hKSzVyPUG4MlA3KG6P MX7TRW5ITVJ?
ES7 M4S3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTF6LkC5JI5O MUPTRW5ITVJ?
HuH-7 NVXxNYlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTF6LkSgcm0> MWHTRW5ITVJ?
BCPAP NHPnTFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDZTWM2OD1zOD62OUBvVQ>? M3nDOnNCVkeHUh?=
SW1710 M{HxbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1z2eGlEPTB;MUiuO|Ihdk1? M3LDd3NCVkeHUh?=
IST-MEL1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfzTWM2OD1zOD63O{BvVQ>? MXvTRW5ITVJ?
SF295 M2TCbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfZTWM2OD1zOD65N{BvVQ>? MmL6V2FPT0WU
RPMI-7951 M3WxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG3ZmtKSzVyPUG5MlI5KG6P M1nM[3NCVkeHUh?=
SF126 M1jCUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF7LkSxJI5O NYTEW4duW0GQR1XS
GAMG NX[ycG9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTF7LkS4JI5O NF;LTIdUSU6JRWK=
KNS-81-FD NV7wdpR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zqN2lEPTB;MUmuOVQhdk1? NGrCZYtUSU6JRWK=
RT-112 NHXiWZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvzWodKSzVyPUG5MlY3KG6P NUnXXmxRW0GQR1XS
DEL NXXYOIFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTRTWM2OD1{MD60PUBvVQ>? MnrHV2FPT0WU
CGTH-W-1 M{PkW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHL1O2RKSzVyPUKwMlY{KG6P M3yzenNCVkeHUh?=
HOS M3nOS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nl[GlEPTB;MkGuNFYhdk1? NUPGbXpMW0GQR1XS
ES4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3znc2lEPTB;MkGuNFghdk1? MYfTRW5ITVJ?
RXF393 M1nvN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTJzLkS1JI5O NEHXfXFUSU6JRWK=
NCI-H2030 NVLQTVc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTJzLkWyJI5O M1ThSnNCVkeHUh?=
YH-13 M{GyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT0Xo5ZUUN3ME2yNU45QCCwTR?= NHHOUlRUSU6JRWK=
HT-1080 M{i0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJzLkmzJI5O MVnTRW5ITVJ?
NCI-SNU-1 MmjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFmxU2hKSzVyPUKxMlk2KG6P MYrTRW5ITVJ?
G-402 NH3E[5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJ{LkG2JI5O M1XabHNCVkeHUh?=
786-0 NF23UVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLJTWM2OD1{Mj6yPUBvVQ>? MV\TRW5ITVJ?
ME-180 MoTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJ{LkSzJI5O NFLUeVRUSU6JRWK=
NB69 NUTKZ2tmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DpUWlEPTB;MkKuOVMhdk1? MY\TRW5ITVJ?
J-RT3-T3-5 NGHrU|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zhRmlEPTB;MkKuPVYhdk1? NFTnZ|RUSU6JRWK=
TGBC1TKB NFfVOVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3izSWlEPTB;MkOuNFUhdk1? MknFV2FPT0WU
SW780 NIrZR4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFi1TmhKSzVyPUKzMlE{KG6P MXnTRW5ITVJ?
MG-63 NIH6[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTsTWM2OD1{Mz60OUBvVQ>? MoWyV2FPT0WU
BV-173 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;JZYtKSzVyPUKzMlg4KG6P NUfsO|l[W0GQR1XS
CAL-51 NWH2cJRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTJ|Lki5JI5O M4rBNXNCVkeHUh?=
A375 MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3ld4dwUUN3ME2yN{46OyCwTR?= MULTRW5ITVJ?
MEL-HO NX3rRXU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4T3bmlEPTB;MkSuNFQhdk1? MVHTRW5ITVJ?
EFO-27 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO0NVFEUUN3ME2yOE4{OyCwTR?= NHLBcohUSU6JRWK=
Hs-578-T MlKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[wTWM2OD1{ND61PEBvVQ>? NWLUPYRIW0GQR1XS
NBsusSR MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJ2Lk[gcm0> MWDTRW5ITVJ?
CTB-1 M4LV[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHP5bplKSzVyPUK0MlY4KG6P NEPXO3lUSU6JRWK=
FTC-133 M2Ls[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PQeGlEPTB;MkWuNUBvVQ>? MV3TRW5ITVJ?
MOLT-4 MnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJ3LkGyJI5O NETPS4hUSU6JRWK=
HO-1-N-1 MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfxeZh4UUN3ME2yOU4yPSCwTR?= MVjTRW5ITVJ?
ES3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFWzclVKSzVyPUK1MlIzKG6P NXzLV4lKW0GQR1XS
TI-73 NITWd|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\qUmpKSzVyPUK1MlI5KG6P MkjvV2FPT0WU
MPP-89 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJ3LkOyJI5O M3XVSHNCVkeHUh?=
KYSE-150 M4nZ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zUVWlEPTB;MkWuPFkhdk1? MWXTRW5ITVJ?
LXF-289 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rVeGlEPTB;Mk[uNFQhdk1? NXX0bW97W0GQR1XS
SK-LU-1 MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJ4LkG3JI5O NX\2PGRCW0GQR1XS
HOP-92 NYT0[nlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXDbVdKSzVyPUK2MlQ5KG6P NES4XFRUSU6JRWK=
HuO9 M3HtRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjPZ3d1UUN3ME2yOk44PiCwTR?= M1O2OnNCVkeHUh?=
SW962 NFTqfnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDmTWM2OD1{Nj63OkBvVQ>? M120b3NCVkeHUh?=
RS4-11 Mn7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\qfm5KSzVyPUK2MlkyKG6P NW\RZ3FbW0GQR1XS
NCI-H292 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2flemlEPTB;Mkegcm0> NIXQV2VUSU6JRWK=
DB NWLTZYJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHM[nJKSzVyPUK3MlM3KG6P Mn\LV2FPT0WU
SW1088 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1L1WmlEPTB;MkiuNlkhdk1? MmXyV2FPT0WU
A204 M2XnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTJ6LkS3JI5O M2nUeHNCVkeHUh?=
A3-KAW NXjxd4V4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfrcotKSzVyPUK4MlY1KG6P M{fld3NCVkeHUh?=
MV-4-11 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXaTWM2OD1{OD63JI5O NV3IdmVDW0GQR1XS
ES1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PRZ2lEPTB;MkiuPFQhdk1? NYf2THlUW0GQR1XS
ONS-76 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\rVWlEPTB;MkmuNFUhdk1? NX\kbZlKW0GQR1XS
D-263MG M1vWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTJ7LkO1JI5O NXfKTJdRW0GQR1XS
U-2-OS M{fBO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqwS2hTUUN3ME2yPU42KG6P MlG0V2FPT0WU
T98G Mlv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTJ7Lki4JI5O MWrTRW5ITVJ?
GI-ME-N MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnHflhKSzVyPUK5MlkyKG6P MnSwV2FPT0WU
BHT-101 MojSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTNyLkC1JI5O NYC1dWFHW0GQR1XS
NOS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zOe2lEPTB;M{CuNVIhdk1? MXnTRW5ITVJ?
AsPC-1 MonrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP0TWM2OD1|MD6yJI5O MWPTRW5ITVJ?
QIMR-WIL MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;sOZVKSzVyPUOwMlYhdk1? MnzBV2FPT0WU
JVM-3 M{XlRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLWTWM2OD1|MD64N{BvVQ>? MlTVV2FPT0WU
KU-19-19 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3kTWM2OD1|MT6xN{BvVQ>? MkfQV2FPT0WU
OVCAR-8 NFyxbIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X4WGlEPTB;M{GuNlYhdk1? Ml\UV2FPT0WU
BEN M2X3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rvU2lEPTB;M{GuOlMhdk1? MVvTRW5ITVJ?
BE-13 NGTuU4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTNzLkiyJI5O M2PoWnNCVkeHUh?=
EW-18 MlO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1O0NWlEPTB;M{GuPFYhdk1? NEfYbIRUSU6JRWK=
ECC10 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX6T2hbUUN3ME2zNU46PSCwTR?= NIXUdItUSU6JRWK=
CTV-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnxcoZJUUN3ME2zNk45OiCwTR?= Mn\TV2FPT0WU
COLO-800 NIDkS4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrwO4dZUUN3ME2zNk46OiCwTR?= MnrhV2FPT0WU
A2058 NFvMS|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jYNWlEPTB;M{OuNlUhdk1? NEPQVINUSU6JRWK=
VM-CUB-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7LeotKSzVyPUOzMlQ{KG6P NX:1fXpzW0GQR1XS
Ca9-22 M4fL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYflNFY3UUN3ME2zN{42PSCwTR?= NFrJdldUSU6JRWK=
COLO-684 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M376SmlEPTB;M{OuOVghdk1? NGnY[|FUSU6JRWK=
RPMI-8226 M3L3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2q3[WlEPTB;M{OuPFIhdk1? NIfBUFJUSU6JRWK=
SK-NEP-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjlbJRKSzVyPUO0MlE2KG6P Mn;EV2FPT0WU
Becker NVfqdmZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17FNWlEPTB;M{SuNlEhdk1? NVeyS|dIW0GQR1XS
NCI-H28 MmjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTu[4JWUUN3ME2zOE41PCCwTR?= NYrieZFUW0GQR1XS
CAL-120 MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XzfGlEPTB;M{SuO|Ihdk1? M4DrdXNCVkeHUh?=
MDA-MB-157 MoPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHGTWM2OD1|NT60NUBvVQ>? MnftV2FPT0WU
OVCAR-5 M1vuemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfOSJBKSzVyPUO1MlQ4KG6P Mlq5V2FPT0WU
LAMA-84 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XKb2lEPTB;M{WuPFchdk1? NVLBN3ZHW0GQR1XS
CAKI-1 M3\CS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{npSGlEPTB;M{[uOFMhdk1? M1PyVXNCVkeHUh?=
Daoy MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTN4Lkegcm0> MUXTRW5ITVJ?
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CAL-39 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEflXppKSzVyPUO3Mlkhdk1? MlXYV2FPT0WU
MN-60 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTOd4x3UUN3ME2zO{46PiCwTR?= NWrMUotjW0GQR1XS
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CAL-12T M1XDWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjYOm1KSzVyPUO4MlYhdk1? MlzVV2FPT0WU
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CO-314 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrPdYNKSzVyPUO4Mlc1KG6P MknDV2FPT0WU
LB1047-RCC NI\ERmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n4fWlEPTB;M{iuPFEhdk1? NVfVUWdJW0GQR1XS
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NCI-H2452 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXVOVBKSzVyPUS0MlU5KG6P NWXwcY93W0GQR1XS
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HD-MY-Z MonwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHtbJZKSzVyPUS0MlkzKG6P MULTRW5ITVJ?
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KYSE-180 M4DYdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTR4LkG3JI5O MnHUV2FPT0WU
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LB996-RCC M2\SfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfUV2FKSzVyPUS3MlE6KG6P M3nReXNCVkeHUh?=
NCI-H1623 MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nK[2lEPTB;NEeuO|Yhdk1? NIPNbJZUSU6JRWK=
NCI-H1155 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\VNWlEPTB;NEiuN|Ihdk1? MWHTRW5ITVJ?
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PFSK-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P1UGlEPTB;NEmuNFYhdk1? MlXxV2FPT0WU
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COR-L23 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDNTXJ{UUN3ME20PU4yPiCwTR?= M{mwOXNCVkeHUh?=
D-283MED MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHn5dWtKSzVyPUS5MlYyKG6P NHzafYhUSU6JRWK=
SW982 NUHZS24zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H6WmlEPTB;NEmuPVEhdk1? NFH3To1USU6JRWK=
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KYSE-140 NYnNRYNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2GzWWlEPTB;NUCuOVUhdk1? NV35VXBmW0GQR1XS
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MHH-ESS-1 NEDJNYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWj5PXdRUUN3ME21NU46PSCwTR?= MmGwV2FPT0WU
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RPMI-2650 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzHTWM2OD13Mj62PUBvVQ>? Mnq5V2FPT0WU
GR-ST MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LNW2lEPTB;NUKuPFchdk1? MUDTRW5ITVJ?
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SK-MES-1 NG\xcXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PJPWlEPTB;NUOuNlYhdk1? MVLTRW5ITVJ?
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RVH-421 NH3scXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX24S|BuUUN3ME21N{43PyCwTR?= MmLoV2FPT0WU
C32 M4L1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTV|LkizJI5O MkPDV2FPT0WU
GB-1 NFvBPXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTV2LkKgcm0> M1zwWnNCVkeHUh?=
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NKM-1 NYG1fpczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnI[lJKSzVyPUW0MlgyKG6P M3XKV3NCVkeHUh?=
NCI-H2405 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTV2Lki4JI5O M3jXc3NCVkeHUh?=
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HAL-01 MnX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfhbllKSzVyPUW1Mlg{KG6P M3y1dHNCVkeHUh?=
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KY821 M{PWbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELMcoxKSzVyPUW2MlIhdk1? NH;wN2ZUSU6JRWK=
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RO82-W-1 NITQcYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3GXY5KSzVyPUW5Mlkhdk1? MX;TRW5ITVJ?
M14 NVXPfmM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P4fGlEPTB;NkCuNFQhdk1? NEPBfZVUSU6JRWK=
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DMS-273 M{jCNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHFfmtKSzVyPU[wMlg4KG6P MVXTRW5ITVJ?
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MSTO-211H MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFSxd2dKSzVyPU[zMlUyKG6P MYLTRW5ITVJ?
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M059J MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTZ|LkW4JI5O NETGOG1USU6JRWK=
LN-405 NVvTb|BNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrLZ|lVUUN3ME22N{45PSCwTR?= MVfTRW5ITVJ?
NCI-H1581 MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TONmlEPTB;NkSuNFMhdk1? MmD0V2FPT0WU
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OVCAR-4 NYPJfHdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFi1cYdKSzVyPUezMlM3KG6P NGe2WlVUSU6JRWK=
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PANC-03-27 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHG0TWJKSzVyPUe2MlI2KG6P MVXTRW5ITVJ?
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