Dactolisib (BEZ235)

For research use only. Not for use in humans.

目录号:S1009 别名: NVP-BEZ235 中文名称:达克利司

Dactolisib (BEZ235) Chemical Structure

CAS No. 915019-65-7

Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Dactolisib可诱导自噬并抑制HIV-1的复制。Phase 2。

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客户使用Selleck生产的Dactolisib (BEZ235)发表文献416篇:

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Dactolisib可诱导自噬并抑制HIV-1的复制。Phase 2。
靶点
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
体外研究

BEZ235显著降低mTOR活化的激酶p70S6K的磷酸化水平。BEZ235导致S235/S236P-RPS6水平减少,IC50为6.5 nM。BEZ235抗mTOR的活性使用生化mTOR K-LISA试验测定,IC50为20.7 nM。BEZ235对其β旁系同源物的活性稍弱,IC50为75 nM。在人肿瘤细胞中,PI3K/Akt/mTOR通路经常被组成性活化。BEZ235阻断PI3K和mTOR激酶活性,通过结合于这些酶的ATP结合槽发挥作用。用逐渐增加浓度BEZ235处理PTEN-null细胞系PC3M和U87MG时,导致细胞增殖剂量依赖性减少,平均GI50为10-12 nM。[1] BEZ235是一种mTORC1/2催化抑制剂。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MkXNRY51cW2rY4LvZolidCCDc4PhfS=> NXXB[nBzOThiaB?= MmfaSG1UVw>? MYDBcpRqfHK7cHHuc5NwdWGuIHHjeIl3cXS7IIfpeIghTUN3MDDv[kAxNjByMkWg{txO NYLPcmJtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NFU6PDZpPkK0PFA2QTR4PD;hQi=>
MCF7 NXTm[VdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzucItvOC5yMT2xNFAh|ryP NX:z[4wxPDhiaB?= NILvPWtFVVOR NWXpd|NMUUN3ME2wMlc{KM7:TR?= M4G0fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEexPVA1Lz5{M{i3NVkxPDxxYU6=
HCT116 MnTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfQUpVwOC5yMT2xNFAh|ryP NWm5bYZmPDhiaB?= M1X6e2ROW09? NWfSNVlRUUN3ME2xMlE3KM7:TR?= MlfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6N{G5NFQoRjJ|OEexPVA1RC:jPh?=
U87MG NE\UTFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHDcINSOC5yMT2xNFAh|ryP MUi0PEBp MnTTSG1UVw>? MXfJR|UxRTFwM{Kg{txO M37JWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEexPVA1Lz5{M{i3NVkxPDxxYU6=
HBC4 NETzO3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7uNE4xOS1zMECg{txO NU\aSIc6PDhiaB?= MnW1UI9oKEeLNUC9MVgvPjFiTR?= MnnPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
BSY1 NWDyToxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnnNE4xOS1zMECg{txO MofLOFghcA>? NXO5UYdGVG:pIFfJOVA:NThwNEigUS=> NHvDS3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
HBC5 M3HhcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPnXnoxNjBzLUGwNEDPxE1? MV[0PEBp MkHHUI9oKEeLNUC9MVcvQDdiTR?= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
MCF7 M2rreWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;ZPIwxNjBzLUGwNEDPxE1? NVr1[|ZoPDhiaB?= NYiy[ZQ4VG:pIFfJOVA:NThwMU[gUS=> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
MDA-MB-231 M{LpTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVWwMlAyNTFyMDFOwG0> MmrnOFghcA>? M1nmcGxw\yCJSUWwQU05NjB7IF2= M1jOb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
U251 NWHmbG0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rDTFAvODFvMUCwJO69VQ>? NUi5d21RPDhiaB?= MXrMc4chT0l3ME2tO{43PiCP MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
SF268 NXHOVZBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PyS|AvODFvMUCwJO69VQ>? MlnyOFghcA>? M2m0emxw\yCJSUWwQU04Njl{IF2= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
SF295 NVXIdYEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjhd4dwOC5yMT2xNFAh|ryP NED1UIs1QCCq MkPEUI9oKEeLNUC9MVgvOzFiTR?= NX;NVGN[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
SF539 MoPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;RRZlKOC5yMT2xNFAh|ryP MYO0PEBp MmHuUI9oKEeLNUC9MVgvPTliTR?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
SNB75 NYLzZXlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m1c|AvODFvMUCwJO69VQ>? M1e0bFQ5KGh? M1qzfGxw\yCJSUWwQU05NjV6IF2= NIXUd5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
SNB78 NYKwXmFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrINE4xOS1zMECg{txO M3z1bVQ5KGh? MlvvUI9oKEeLNUC9MVgvPjViTR?= NXjtU3k3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
HCC2998 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3reWRPOC5yMT2xNFAh|ryP NEnjdFc1QCCq NFnvVJJNd2diR1m1NF0uQC5yNTDN M{OwNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
KM12 NGj4cYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXwNE4xOS1zMECg{txO MVy0PEBp NUPKWWl5VG:pIFfJOVA:NTdwNUSgUS=> M2fqblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
HT-29 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\4XVAvODFvMUCwJO69VQ>? M17lfVQ5KGh? M3:3VGxw\yCJSUWwQU04Njd3IF2= NEG1c5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
HCT15 Mm\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkD4NE4xOS1zMECg{txO NFX3bJY1QCCq MX3Mc4chT0l3ME2tPE4xOyCP NIfSVW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
HCT116 M{XRe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHnUYQxNjBzLUGwNEDPxE1? NYXL[YFNPDhiaB?= NVfYNmlYVG:pIFfJOVA:NTdwNkGgUS=> MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
NCI-H23 M{GybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2W0fVAvODFvMUCwJO69VQ>? M4nYUFQ5KGh? MXvMc4chT0l3ME2tO{43PCCP MlPIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
NCI-H226 NVfBZ4l2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnO2NE4xOS1zMECg{txO NGLBPI01QCCq NFnzRWFNd2diR1m1NF0uQC52NDDN MlzJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
NCI-H522 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW2ZoUxNjBzLUGwNEDPxE1? MlX0OFghcA>? NGr1RlBNd2diR1m1NF0uQC52NTDN MoDiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
NCI-H438 NGO2Z2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjNPIdlOC5yMT2xNFAh|ryP MmO0OFghcA>? M3rQdmxw\yCJSUWwQU05NjFzIF2= NWDyWploRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
A549 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1O2RlAvODFvMUCwJO69VQ>? M4LzSFQ5KGh? MX\Mc4chT0l3ME2tPE4xPyCP MoLwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
DMS273 M3u5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTzO2UxNjBzLUGwNEDPxE1? M3HtflQ5KGh? M2\WTGxw\yCJSUWwQU04NjhyIF2= NV\PWmVJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
DMS114 NG\VU2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\rOY1ROC5yMT2xNFAh|ryP MoDUOFghcA>? M2LoSmxw\yCJSUWwQU05NjN7IF2= M{f5XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
LOXIMVI MkTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUmwMlAyNTFyMDFOwG0> M{W0UFQ5KGh? MnvZUI9oKEeLNUC9MVgvPjZiTR?= NYW4OlRzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
OVCAR3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlywNE4xOS1zMECg{txO M3rVeVQ5KGh? MVrMc4chT0l3ME2tPE4yPyCP NFS2Z|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
OVCAR4 MnTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUmzPYxJOC5yMT2xNFAh|ryP MkLPOFghcA>? MYDMc4chT0l3ME2tPE42QCCP M3jpR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
OVCAR5 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXBNE4xOS1zMECg{txO MY[0PEBp M3KxTWxw\yCJSUWwQU04NjV5IF2= NWXRWodiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
OVCAR8 NHP5VVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYmwMlAyNTFyMDFOwG0> NVzCOIprPDhiaB?= NYjQOYlKVG:pIFfJOVA:NTdwOESgUS=> MoTaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
SKOV3 NH;QcW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLWW21FOC5yMT2xNFAh|ryP NUXNTGoxPDhiaB?= M4L4XGxw\yCJSUWwQU05NjRzIF2= Mo\LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
RXF631L NUDKN5d1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XjdVAvODFvMUCwJO69VQ>? M4TSUlQ5KGh? M3HOTWxw\yCJSUWwQU05NjJzIF2= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
ACHN NWXvOWJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknMNE4xOS1zMECg{txO MknnOFghcA>? NHzhbmZNd2diR1m1NF0uPy57NTDN NWO5ZYY1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
St-4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\yRVAvODFvMUCwJO69VQ>? MVS0PEBp Mm\1UI9oKEeLNUC9MVcvPDdiTR?= NHrlTIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
MKN1 NFLpbnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fCXFAvODFvMUCwJO69VQ>? NXThNVduPDhiaB?= MW\Mc4chT0l3ME2tPE41OSCP Mn7RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
MKN7 MnvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTuVmsyOC5yMT2xNFAh|ryP MmC3OFghcA>? M3f6W2xw\yCJSUWwQU04NjZ6IF2= NHnjd5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
MKN28 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYizcGZ3OC5yMT2xNFAh|ryP NGPXUYQ1QCCq NYfkeWljVG:pIFfJOVA:NTdwMEegUS=> NF3ES|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
MKN45 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XGflAvODFvMUCwJO69VQ>? MVy0PEBp NH\nblRNd2diR1m1NF0uQC5|NDDN MnG5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
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BB65-RCC M4LKe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fLdWlEPTB;MUKuO|Ihdk1? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
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GCT M3nSN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXubohJUUN3ME2xN{43QCCwTR?= NWGyVXdnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
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LB2241-RCC NFLEdllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHzUWE6UUN3ME2xOE4xOSCwTR?= Mn;IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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NCI-H2452 NWHBOFFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DlR2lEPTB;NESuOVghdk1? MmfYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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PC-14 MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTR4LkW3JI5O NVLKOW82RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
TE-5 MmjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHJcGlKSzVyPUS2Mlg1KG6P Mn;4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
LB996-RCC MmrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HFNGlEPTB;NEeuNVkhdk1? Mn7mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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LC-2-ad