Dactolisib (BEZ235)

For research use only. Not for use in humans.

目录号:S1009 别名: NVP-BEZ235 中文名称:达克利司

Dactolisib (BEZ235) Chemical Structure

CAS No. 915019-65-7

Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Dactolisib可诱导自噬并抑制HIV-1的复制。Phase 2。

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客户使用Selleck生产的Dactolisib (BEZ235)发表文献416篇:

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Dactolisib可诱导自噬并抑制HIV-1的复制。Phase 2。
靶点
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
体外研究

BEZ235显著降低mTOR活化的激酶p70S6K的磷酸化水平。BEZ235导致S235/S236P-RPS6水平减少,IC50为6.5 nM。BEZ235抗mTOR的活性使用生化mTOR K-LISA试验测定,IC50为20.7 nM。BEZ235对其β旁系同源物的活性稍弱,IC50为75 nM。在人肿瘤细胞中,PI3K/Akt/mTOR通路经常被组成性活化。BEZ235阻断PI3K和mTOR激酶活性,通过结合于这些酶的ATP结合槽发挥作用。用逐渐增加浓度BEZ235处理PTEN-null细胞系PC3M和U87MG时,导致细胞增殖剂量依赖性减少,平均GI50为10-12 nM。[1] BEZ235是一种mTORC1/2催化抑制剂。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MorxRY51cW2rY4LvZolidCCDc4PhfS=> M3y5VFE5KGh? NFrnOZNFVVOR MmDxRY51cXS{eYDhco9{d22jbDDhZ5Rqfmm2eTD3bZRpKEWFNUCgc4YhOC5yMEK1JO69VQ>? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhyNUm0Okc,OjR6MEW5OFY9N2F-
MCF7 NHnafVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFX1dnAxNjBzLUGwNEDPxE1? NFrUUYo1QCCq MU\EUXNQ NVm2dFRyUUN3ME2wMlc{KM7:TR?= NE[0RZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i3NVkxPCd-MkO4O|E6ODR:L3G+
HCT116 M3jmV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDIbHNVOC5yMT2xNFAh|ryP NFeydZA1QCCq MVrEUXNQ MV\JR|UxRTFwMU[g{txO NFHzW4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i3NVkxPCd-MkO4O|E6ODR:L3G+
U87MG NYjSTII5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfGXo8xNjBzLUGwNEDPxE1? NIqxTHU1QCCq MofoSG1UVw>? NECzNpNKSzVyPUGuN|Ih|ryP Mn\VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6N{G5NFQoRjJ|OEexPVA1RC:jPh?=
HBC4 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHld2RVOC5yMT2xNFAh|ryP NWLrTHBZPDhiaB?= MXLMc4chT0l3ME2tPE43OSCP MoHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
BSY1 NWm0dolvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfOTFZSOC5yMT2xNFAh|ryP NXrV[ncxPDhiaB?= NFnTW4RNd2diR1m1NF0uQC52ODDN NX;JTG5KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
HBC5 NVPKfFN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXywMlAyNTFyMDFOwG0> M4DTN|Q5KGh? MXXMc4chT0l3ME2tO{45PyCP NIL2SFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
MCF7 MlfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXle4YxNjBzLUGwNEDPxE1? NX[zTmNzPDhiaB?= NXHTcVc6VG:pIFfJOVA:NThwMU[gUS=> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
MDA-MB-231 NEfzVlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3HU415OC5yMT2xNFAh|ryP Mlr0OFghcA>? M3zjUmxw\yCJSUWwQU05NjB7IF2= MkPvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
U251 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO1NE4xOS1zMECg{txO Mn\JOFghcA>? NGWx[YJNd2diR1m1NF0uPy54NjDN M4DDeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
SF268 NEDJ[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWL2UHlmOC5yMT2xNFAh|ryP M{HuWVQ5KGh? NUj5d2E4VG:pIFfJOVA:NTdwOUKgUS=> M{HQRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
SF295 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDSfHdkOC5yMT2xNFAh|ryP NHPRV3E1QCCq M4DMUmxw\yCJSUWwQU05NjNzIF2= MmjaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
SF539 M4LEO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:ye29POC5yMT2xNFAh|ryP NV[1[Y5sPDhiaB?= NGXhSmdNd2diR1m1NF0uQC53OTDN NUXTUohoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
SNB75 Mnz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoWyNE4xOS1zMECg{txO M3zKOFQ5KGh? NYDrU5RbVG:pIFfJOVA:NThwNUigUS=> M1rPTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
SNB78 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXewMlAyNTFyMDFOwG0> NIfldIo1QCCq NGH4cZlNd2diR1m1NF0uQC54NTDN M4OzPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
HCC2998 M1j4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorRNE4xOS1zMECg{txO MV60PEBp NEnaToxNd2diR1m1NF0uQC5yNTDN MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
KM12 NGjTc5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1OxOFAvODFvMUCwJO69VQ>? NV3HU|BkPDhiaB?= M3rlN2xw\yCJSUWwQU04NjV2IF2= M1jZR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
HT-29 NXPYPVZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHWU3JUOC5yMT2xNFAh|ryP MVq0PEBp MnyyUI9oKEeLNUC9MVcvPzViTR?= NVL1XW5HRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
HCT15 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLRNE4xOS1zMECg{txO NHu5eGU1QCCq NIfi[XZNd2diR1m1NF0uQC5yMzDN NHixSlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
HCT116 MkL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUSwMlAyNTFyMDFOwG0> MVW0PEBp MXLMc4chT0l3ME2tO{43OSCP MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
NCI-H23 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7UNE4xOS1zMECg{txO MmHUOFghcA>? NWKye5RQVG:pIFfJOVA:NTdwNkSgUS=> NEHhdo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
NCI-H226 NIfRUJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTkW2twOC5yMT2xNFAh|ryP MWS0PEBp NHT5dpdNd2diR1m1NF0uQC52NDDN NVvoSHc6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
NCI-H522 NF3YZoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPONE4xOS1zMECg{txO MWe0PEBp MWrMc4chT0l3ME2tPE41PSCP NH\TbVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
NCI-H438 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;GRnExNjBzLUGwNEDPxE1? NUX3cpY6PDhiaB?= M{i0Umxw\yCJSUWwQU05NjFzIF2= NYrvRXFiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
A549 NUjUS4ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX[wMlAyNTFyMDFOwG0> NHG0SIQ1QCCq M{\ZNGxw\yCJSUWwQU05NjB5IF2= Mmf1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
DMS273 NWLxXGJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvCNE4xOS1zMECg{txO MYG0PEBp NEjFZ2hNd2diR1m1NF0uPy56MDDN M2TzWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
DMS114 NEHkW4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDRellqOC5yMT2xNFAh|ryP MWK0PEBp M4C0Umxw\yCJSUWwQU05NjN7IF2= NWHjNoU3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
LOXIMVI MnnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3q2XlAvODFvMUCwJO69VQ>? NGHLd2k1QCCq NFfPe5RNd2diR1m1NF0uQC54NjDN M3fCSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
OVCAR3 M1;3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXrSlcxNjBzLUGwNEDPxE1? MU[0PEBp NXT3XlMzVG:pIFfJOVA:NThwMUegUS=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
OVCAR4 NFzSToFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3hXogxNjBzLUGwNEDPxE1? MVW0PEBp MVPMc4chT0l3ME2tPE42QCCP MkDYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
OVCAR5 NEjQcZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTwOWcxNjBzLUGwNEDPxE1? NWXKXld[PDhiaB?= M3zmR2xw\yCJSUWwQU04NjV5IF2= NYjDdmdXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
OVCAR8 NHW4fXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjPXVMxNjBzLUGwNEDPxE1? NFXpcm01QCCq MofQUI9oKEeLNUC9MVcvQDRiTR?= MkjIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
SKOV3 MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXTVGQxNjBzLUGwNEDPxE1? NV3kRXpMPDhiaB?= MVXMc4chT0l3ME2tPE41OSCP M1PUNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
RXF631L NYW3U29QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLZNE4xOS1zMECg{txO MnXKOFghcA>? NXnLVoFlVG:pIFfJOVA:NThwMkGgUS=> NUf6VpY2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
ACHN M{PZfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPJOmZmOC5yMT2xNFAh|ryP MYm0PEBp NXvzTWdnVG:pIFfJOVA:NTdwOUWgUS=> MojsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
St-4 MkXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjwNVkxNjBzLUGwNEDPxE1? NYDLUpRjPDhiaB?= MkT0UI9oKEeLNUC9MVcvPDdiTR?= NUXrXpk{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
MKN1 MoLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvnNE4xOS1zMECg{txO Mm[4OFghcA>? MmHsUI9oKEeLNUC9MVgvPDFiTR?= M1jmZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
MKN7 NU\XW3ZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LNeFAvODFvMUCwJO69VQ>? MmDqOFghcA>? Ml\IUI9oKEeLNUC9MVcvPjhiTR?= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
MKN28 NUHuN|FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\mNE4xOS1zMECg{txO MUC0PEBp MmrOUI9oKEeLNUC9MVcvODdiTR?= Mmr3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
MKN45 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Ht[FAvODFvMUCwJO69VQ>? NVfhdVg3PDhiaB?= M1\lZWxw\yCJSUWwQU05NjN2IF2= NY\OUYFMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
MKN74 MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDUNE4xOS1zMECg{txO M2LWN|Q5KGh? NHntOXNNd2diR1m1NF0uPy52MjDN NV6yOplHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
DU145 NVqwVIdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7jNE4xOS1zMECg{txO NHLhNVE1QCCq NX\5VmlUVG:pIFfJOVA:NThwMU[gUS=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
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Trypanosoma brucei brucei NF;tXHFHfW6ldHnvckBCe3OjeR?= MYOyNFAhdk1? MXixNkBp MU\EUXNQ MWXF[oZm[3Rib36gdIhwe3CqYYTp[Jlt[2ixbHnu[UBt\X[nbB?= M1XOe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEC1PVQ3Lz5{NEiwOVk1PjxxYU6=
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SBC-1 MmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7VTWM2OD15NEKgdG0> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
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NCI-H720 NWP6dnRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jrS2lEPTB;Mz61O{BvVQ>? NV\BOoUxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
BFTC-909 M{jt[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTFb2ZKSzVyPUOuO|Ehdk1? NHm0fFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
BPH-1 M4nJeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnkRXdKUUN3ME20Mlc3KG6P Ml\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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AN3-CA MnTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\PbHk3UUN3ME21MlU3KG6P NUHHfmFsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
HN MlrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTVwOU[gcm0> NXu2RZlCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
HCC2218 M2LGZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXMTWM2OD14Lk[xJI5O M1\MPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
KP-4 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[1TGIyUUN3ME23JI5O M4LESlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
LU-139 Ml;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnKOlBIUUN3ME23Mlc4KG6P M2W4bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
ETK-1 MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjP[GlKSzVyPUeuPFghdk1? MlTIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
Ramos-2G6-4C10 NIXtU5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPOR29KSzVyPUiuOFkhdk1? NEnKWJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
MHH-PREB-1 M3XjZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTlwMUKgcm0> NXnKeZlCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
DU-4475 NH;VcG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzjSYs3UUN3ME25MlQ1KG6P M4ixNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
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CAMA-1 NFi5OnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPTTWM2OD17Lkigcm0> NIr2[GI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
TYK-nu MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTlwOUSgcm0> MmDBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
MFE-280 MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTlwOUmgcm0> M1jqOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
A549 NGXYXWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4GwcmlEPTB;MUCuNVQhdk1? MnLyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
769-P NVjiW3J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIKyWnpKSzVyPUGwMlQ1KG6P MnOzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
L-363 NVvYXJJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvNOXBZUUN3ME2xNE43QSCwTR?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
ES8 M4HNemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTFyLkmgcm0> NHLHTIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
PA-1 MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHITWM2OD1zMT64NkBvVQ>? NV3BUpdbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
Mewo M1\URWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTFzLkm5JI5O M1TTUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
HSC-3 M4PnSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe5OopvUUN3ME2xNk4zOSCwTR?= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
H4 MnjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\Xb2lEPTB;MUKuOlchdk1? MmXCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
BB65-RCC M{[5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTF{LkeyJI5O MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
NCI-H1793 NGHsN2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXBSGxKSzVyPUGyMlgzKG6P NF70Wnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
KARPAS-45 M4HU[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;rUGI5UUN3ME2xN{42OSCwTR?= MlKyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
GCT M4PFNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTF|Lk[4JI5O M3jNc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
EoL-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTF|LkmzJI5O MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
LB2241-RCC NGL6cGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkGxTWM2OD1zND6wNUBvVQ>? NFPs[XU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
ES5 NWrJcY9iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfJTWM2OD1zND63OEBvVQ>? NUP4ZpRXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
LOXIMVI MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHHVYlKSzVyPUG0Mlk6KG6P NG\YfWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
COR-L105 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL2TWM2OD1zNT6wOEBvVQ>? NH:5[Hk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
P12-ICHIKAWA Mlj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLo[VhKSzVyPUG1MlEhdk1? NFf0Rmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
CHL-1 M4XIUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrhTWM2OD1zNT60OUBvVQ>? MkXXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
VMRC-RCZ MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfKOFM2UUN3ME2xOU43OyCwTR?= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
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