Dactolisib (BEZ235)

For research use only. Not for use in humans.

目录号:S1009 别名: NVP-BEZ235 中文名称:达克利司

Dactolisib (BEZ235) Chemical Structure

CAS No. 915019-65-7

Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Dactolisib可诱导自噬并抑制HIV-1的复制。Phase 2。

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RMB 1414.41 现货
RMB 2530.71 现货
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客户使用Selleck生产的Dactolisib (BEZ235)发表文献392篇:

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Dactolisib可诱导自噬并抑制HIV-1的复制。Phase 2。
靶点
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
体外研究

BEZ235显著降低mTOR活化的激酶p70S6K的磷酸化水平。BEZ235导致S235/S236P-RPS6水平减少,IC50为6.5 nM。BEZ235抗mTOR的活性使用生化mTOR K-LISA试验测定,IC50为20.7 nM。BEZ235对其β旁系同源物的活性稍弱,IC50为75 nM。在人肿瘤细胞中,PI3K/Akt/mTOR通路经常被组成性活化。BEZ235阻断PI3K和mTOR激酶活性,通过结合于这些酶的ATP结合槽发挥作用。用逐渐增加浓度BEZ235处理PTEN-null细胞系PC3M和U87MG时,导致细胞增殖剂量依赖性减少,平均GI50为10-12 nM。[1] BEZ235是一种mTORC1/2催化抑制剂。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei M1HQPWFvfGmvaXPyc4Jq[WxiQYPzZZk> MV2xPEBp MX3EUXNQ MlGyRY51cXS{eYDhco9{d22jbDDhZ5Rqfmm2eTD3bZRpKEWFNUCgc4YhOC5yMEK1JO69VQ>? M4P6dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEC1PVQ3Lz5{NEiwOVk1PjxxYU6=
MCF7 NH;nOWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWruSolEOC5yMT2xNFAh|ryP NInSPIE1QCCq MWrEUXNQ MW\JR|UxRTBwN{Og{txO MmfSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6N{G5NFQoRjJ|OEexPVA1RC:jPh?=
HCT116 NHj6WXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDVNE4xOS1zMECg{txO MlftOFghcA>? NVLNS2c{TE2VTx?= NXm5SHF2UUN3ME2xMlE3KM7:TR?= NG[5cWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i3NVkxPCd-MkO4O|E6ODR:L3G+
U87MG NHWwT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z3[|AvODFvMUCwJO69VQ>? M{LCXVQ5KGh? NHPkcoVFVVOR Mn\XTWM2OD1zLkOyJO69VQ>? NV[wepVtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4O|E6ODRpPkKzPFcyQTB2PD;hQi=>
HBC4 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHG4UW4xNjBzLUGwNEDPxE1? NX3q[4doPDhiaB?= NHrJPWdNd2diR1m1NF0uQC54MTDN NGPjfIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
BSY1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnpZXZ[OC5yMT2xNFAh|ryP MoDYOFghcA>? NH7ydYlNd2diR1m1NF0uQC52ODDN NGD6VXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
HBC5 M3nZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXINE4xOS1zMECg{txO NVHveG0xPDhiaB?= NYPBdohFVG:pIFfJOVA:NTdwOEegUS=> NF71SmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
MCF7 M1OzVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfMR|YxOC5yMT2xNFAh|ryP MkCwOFghcA>? NVLBZol{VG:pIFfJOVA:NThwMU[gUS=> M1XDXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
MDA-MB-231 M1LRNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7LNE4xOS1zMECg{txO NH\SZnU1QCCq MYnMc4chT0l3ME2tPE4xQSCP MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
U251 M3q5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vrWVAvODFvMUCwJO69VQ>? MmHNOFghcA>? NVf0N5BlVG:pIFfJOVA:NTdwNk[gUS=> NYnlOG05RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
SF268 NUHoRlZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jCZVAvODFvMUCwJO69VQ>? NEG2blc1QCCq NVHsUWpCVG:pIFfJOVA:NTdwOUKgUS=> M4O1fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
SF295 M2LXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH6WmsxNjBzLUGwNEDPxE1? NWG0WIxNPDhiaB?= M32z[Wxw\yCJSUWwQU05NjNzIF2= MmHSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
SF539 M{W5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYSwMlAyNTFyMDFOwG0> M2TqZlQ5KGh? NUT5PGY3VG:pIFfJOVA:NThwNUmgUS=> NYDlXHIzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
SNB75 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXqwMlAyNTFyMDFOwG0> MXO0PEBp MnPOUI9oKEeLNUC9MVgvPThiTR?= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
SNB78 NHnV[YRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXu0dnhxOC5yMT2xNFAh|ryP M2OxRVQ5KGh? MkewUI9oKEeLNUC9MVgvPjViTR?= MonXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
HCC2998 NGnndWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7pVnQxNjBzLUGwNEDPxE1? MlXFOFghcA>? NUj2cHpuVG:pIFfJOVA:NThwMEWgUS=> M1HYXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
KM12 NGnHT2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLZbJQxNjBzLUGwNEDPxE1? NVLnbohDPDhiaB?= M1nQZ2xw\yCJSUWwQU04NjV2IF2= M1n3N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
HT-29 NIe5VZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHkNE4xOS1zMECg{txO M3zlS|Q5KGh? NXvMeYZ6VG:pIFfJOVA:NTdwN{WgUS=> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
HCT15 M3jCV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1q1bFAvODFvMUCwJO69VQ>? NH;BXoc1QCCq M13QVWxw\yCJSUWwQU05NjB|IF2= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
HCT116 MkjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVywMlAyNTFyMDFOwG0> NVzqS|FUPDhiaB?= MkXUUI9oKEeLNUC9MVcvPjFiTR?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
NCI-H23 M{HqOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHsdWtVOC5yMT2xNFAh|ryP M2LZSVQ5KGh? NGLq[IhNd2diR1m1NF0uPy54NDDN MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
NCI-H226 M3z4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvJeJcxNjBzLUGwNEDPxE1? MUe0PEBp NV3MPGlyVG:pIFfJOVA:NThwNESgUS=> NYHOOFdERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
NCI-H522 M1nJTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWOwMlAyNTFyMDFOwG0> NVHBWXRCPDhiaB?= Mme0UI9oKEeLNUC9MVgvPDViTR?= M3L6RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
NCI-H438 NETaRpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY[wMlAyNTFyMDFOwG0> MUm0PEBp MVTMc4chT0l3ME2tPE4yOSCP NVvacZVjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
A549 Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLoNE4xOS1zMECg{txO NHv6[ZA1QCCq M4TMWWxw\yCJSUWwQU05NjB5IF2= MmK3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
DMS273 M3m3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYWwMlAyNTFyMDFOwG0> NFTNZ3E1QCCq NGi0e5BNd2diR1m1NF0uPy56MDDN MnfJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
DMS114 NH;2XndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Lm[VAvODFvMUCwJO69VQ>? NGrUTHQ1QCCq MUfMc4chT0l3ME2tPE4{QSCP M3zLNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
LOXIMVI MnuzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfmNE4xOS1zMECg{txO NGTxTpc1QCCq M4HGW2xw\yCJSUWwQU05NjZ4IF2= M3;4[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
OVCAR3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4mwXlAvODFvMUCwJO69VQ>? NWrhVnlbPDhiaB?= MWXMc4chT0l3ME2tPE4yPyCP NVLrSnA6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
OVCAR4 MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoizNE4xOS1zMECg{txO NFy3Tm81QCCq MXHMc4chT0l3ME2tPE42QCCP MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
OVCAR5 M4PiR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfhWGtTOC5yMT2xNFAh|ryP M1jyUFQ5KGh? NUfzeYo2VG:pIFfJOVA:NTdwNUegUS=> MnezQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
OVCAR8 NWCwTIpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDmVYRxOC5yMT2xNFAh|ryP NWDYTmx1PDhiaB?= NGCxOY1Nd2diR1m1NF0uPy56NDDN NY\0UmNwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
SKOV3 M1nnRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYT4TXNvOC5yMT2xNFAh|ryP MlPjOFghcA>? NX6yXIc1VG:pIFfJOVA:NThwNEGgUS=> NVfScYsxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
RXF631L NWHIOmF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3FfmExNjBzLUGwNEDPxE1? M13BS|Q5KGh? NHvwbXdNd2diR1m1NF0uQC5{MTDN M3LaUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
ACHN MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHRbGdLOC5yMT2xNFAh|ryP NHX0b2E1QCCq MkjzUI9oKEeLNUC9MVcvQTViTR?= NWr0dIdFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
St-4 NEPWZWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjTN4ZKOC5yMT2xNFAh|ryP NEPQeJE1QCCq Mlj0UI9oKEeLNUC9MVcvPDdiTR?= NXPEcHplRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
MKN1 NX65WFhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXmwMlAyNTFyMDFOwG0> NG\2UVg1QCCq MkfJUI9oKEeLNUC9MVgvPDFiTR?= M{P1[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
MKN7 MkK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LJd|AvODFvMUCwJO69VQ>? NIDpblM1QCCq NInhT4xNd2diR1m1NF0uPy54ODDN MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
MKN28 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLFcGl3OC5yMT2xNFAh|ryP MUe0PEBp MWHMc4chT0l3ME2tO{4xPyCP M3K4V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
MKN45 NXW5d3d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTaNE4xOS1zMECg{txO NXLoemY2PDhiaB?= MmP4UI9oKEeLNUC9MVgvOzRiTR?= MkTLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
MKN74 M1rvPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS3e5QxNjBzLUGwNEDPxE1? NYrXT4hJPDhiaB?= NYT5TnREVG:pIFfJOVA:NTdwNEKgUS=> MljqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
DU145 MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7kcIUxNjBzLUGwNEDPxE1? NFn2SFg1QCCq M4\xOWxw\yCJSUWwQU05NjF4IF2= NVzXN2JCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
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KP-4 NIPTWJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPrd3hKSzVyPUegcm0> NX\xcGozRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
LU-139 MkXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTdwN{egcm0> NU\VbGpRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
ETK-1 Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfMcFJpUUN3ME23Mlg5KG6P MkP3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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DU-4475 M{DxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\4VXNKSzVyPUmuOFQhdk1? MnfLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
NCI-H1666 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvIdGpKSzVyPUmuO|Ehdk1? NFnMboM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
CAMA-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTlwODDuUS=> NUHheY1FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
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A549 M3\6c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYn2c|MzUUN3ME2xNE4yPCCwTR?= NFnzUGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
769-P MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTFyLkS0JI5O MlnpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
L-363 NIjRPYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvFR49KSzVyPUGwMlY6KG6P NF6xNlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
ES8 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvkNZkxUUN3ME2xNE46KG6P NUjUUY5GRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
PA-1 NFXN[FZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXr[XFKSzVyPUGxMlgzKG6P M2DSVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
Mewo NITxW45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTFzLkm5JI5O MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
HSC-3 NHjpTlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTF{LkKxJI5O NXzDRXM1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
H4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjMZmxKSzVyPUGyMlY4KG6P MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
BB65-RCC MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX5WodKSzVyPUGyMlczKG6P MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
NCI-H1793 MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTufJlSUUN3ME2xNk45OiCwTR?= Mm\MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
KARPAS-45 M1zydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTF|LkWxJI5O M2rxPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
GCT MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV22cVByUUN3ME2xN{43QCCwTR?= NVvvU3M5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
EoL-1 Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXG3PFRuUUN3ME2xN{46OyCwTR?= MnjyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
LB2241-RCC MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL3TWM2OD1zND6wNUBvVQ>? NVXFPHJZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
ES5 NEnBU5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmGwTWM2OD1zND63OEBvVQ>? NFXCZlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
LOXIMVI NGPYR|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDjdop[UUN3ME2xOE46QSCwTR?= M37TS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
COR-L105 NYm4b|B3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\ncIhKSzVyPUG1MlA1KG6P M17iOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
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CHL-1 MkXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjvOm9KSzVyPUG1MlQ2KG6P MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
VMRC-RCZ M4TIR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDIclNKSzVyPUG1MlY{KG6P MnLaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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HCC1419 M2TYOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLRTWM2OD1|OD63NUBvVQ>? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
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NB5 MlvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXewd4djUUN3ME20NE43PCCwTR?= NHXlbYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
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NTERA-S-cl-D1 NV7HPGl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYCycFZpUUN3ME20N{BvVQ>? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
T-24 MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPyOIJMUUN3ME20N{45OyCwTR?= NWDx[o57RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
EPLC-272H M3jZPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDtTWM2OD12ND6zPUBvVQ>? NH;zflM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
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KS-1 NGnudHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXoRWhKSzVyPUS0MlY3KG6P MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
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KYSE-180 MnXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13jTGlEPTB;NE[uNVchdk1? NXfkcJpuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
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NCI-H1355 NYLCcnVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzZNZo3UUN3ME20Ok4{PCCwTR?= Ml[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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PC-14 NHPHfoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf6RpJKSzVyPUS2MlU4KG6P NH\Lbos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
TE-5 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTR4Lki0JI5O NFLIdnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
LB996-RCC NXfYdW9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\KemlEPTB;NEeuNVkhdk1? NXS0enpvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
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