Dactolisib (BEZ235)

For research use only. Not for use in humans.

目录号:S1009 别名: NVP-BEZ235 中文名称:达克利司

Dactolisib (BEZ235) Chemical Structure

CAS No. 915019-65-7

Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Dactolisib可诱导自噬并抑制HIV-1的复制。Phase 2。

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RMB 895.88 现货
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RMB 2530.71 现货
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客户使用Selleck生产的Dactolisib (BEZ235)发表文献407篇:

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Dactolisib可诱导自噬并抑制HIV-1的复制。Phase 2。
靶点
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
体外研究

BEZ235显著降低mTOR活化的激酶p70S6K的磷酸化水平。BEZ235导致S235/S236P-RPS6水平减少,IC50为6.5 nM。BEZ235抗mTOR的活性使用生化mTOR K-LISA试验测定,IC50为20.7 nM。BEZ235对其β旁系同源物的活性稍弱,IC50为75 nM。在人肿瘤细胞中,PI3K/Akt/mTOR通路经常被组成性活化。BEZ235阻断PI3K和mTOR激酶活性,通过结合于这些酶的ATP结合槽发挥作用。用逐渐增加浓度BEZ235处理PTEN-null细胞系PC3M和U87MG时,导致细胞增殖剂量依赖性减少,平均GI50为10-12 nM。[1] BEZ235是一种mTORC1/2催化抑制剂。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei NEHENVRCdnSrbXnjdo9jcWGuIFHzd4F6 MWKxPEBp MoLiSG1UVw>? M3X1OGFvfGm2conwZY5we2:vYXygZYN1cX[rdImge4l1cCCHQ{WwJI9nKDBwMECyOUDPxE1? MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhyNUm0Okc,OjR6MEW5OFY9N2F-
MCF7 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknONE4xOS1zMECg{txO MYS0PEBp MXHEUXNQ Mn\5TWM2OD1yLkezJO69VQ>? M1;ZUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEexPVA1Lz5{M{i3NVkxPDxxYU6=
HCT116 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fvdlAvODFvMUCwJO69VQ>? NGi5OVg1QCCq NUPXRZoyTE2VTx?= NX\VVpdIUUN3ME2xMlE3KM7:TR?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh5MUmwOEc,OjN6N{G5NFQ9N2F-
U87MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkm0NE4xOS1zMECg{txO NGG5ZnI1QCCq MV;EUXNQ NF:y[I9KSzVyPUGuN|Ih|ryP NFrtWnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i3NVkxPCd-MkO4O|E6ODR:L3G+
HBC4 NUCwb49YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIqxZVQxNjBzLUGwNEDPxE1? NHnNPYw1QCCq NXvkcXR2VG:pIFfJOVA:NThwNkGgUS=> MnnDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
BSY1 MmXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DxWlAvODFvMUCwJO69VQ>? MU[0PEBp NFH0bolNd2diR1m1NF0uQC52ODDN NHG0TmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
HBC5 NIrMXpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\Pfo8xNjBzLUGwNEDPxE1? NGrrXYw1QCCq M1LoTmxw\yCJSUWwQU04Njh5IF2= NWDteVFuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
MCF7 NVPXUpVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUmwMlAyNTFyMDFOwG0> MW[0PEBp NV3aepR{VG:pIFfJOVA:NThwMU[gUS=> M2e4SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
MDA-MB-231 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInBN|cxNjBzLUGwNEDPxE1? NX\LUJdXPDhiaB?= MoTqUI9oKEeLNUC9MVgvODliTR?= MlTVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
U251 MmnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjhSnExOC5yMT2xNFAh|ryP NVq3clEyPDhiaB?= MlmzUI9oKEeLNUC9MVcvPjZiTR?= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
SF268 NUXaPYtJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\ubHV6OC5yMT2xNFAh|ryP MlnzOFghcA>? MXTMc4chT0l3ME2tO{46OiCP Ml;TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
SF295 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4e3T|AvODFvMUCwJO69VQ>? NFvKWpc1QCCq Mmr6UI9oKEeLNUC9MVgvOzFiTR?= NEjDc2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
SF539 M4rUcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\sNE4xOS1zMECg{txO MUm0PEBp MYnMc4chT0l3ME2tPE42QSCP MoLzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
SNB75 M4ricGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[1NE4xOS1zMECg{txO MUe0PEBp M1PCSWxw\yCJSUWwQU05NjV6IF2= NUi5WWNZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
SNB78 NEDVbVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\VeVAvODFvMUCwJO69VQ>? MWO0PEBp NXf4fm45VG:pIFfJOVA:NThwNkWgUS=> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
HCC2998 Mn\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHoe4liOC5yMT2xNFAh|ryP NE\nWok1QCCq MVvMc4chT0l3ME2tPE4xPSCP MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
KM12 MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3n2[VAvODFvMUCwJO69VQ>? NX;C[Y5MPDhiaB?= M{j0XWxw\yCJSUWwQU04NjV2IF2= NVTO[mM{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
HT-29 M2m1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWSwMlAyNTFyMDFOwG0> NHTndoc1QCCq NHe2SVZNd2diR1m1NF0uPy55NTDN MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
HCT15 M2G5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfTNWpbOC5yMT2xNFAh|ryP MUW0PEBp NXLMdnVJVG:pIFfJOVA:NThwMEOgUS=> NYrqT5pTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
HCT116 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGyNE4xOS1zMECg{txO NUDQXYVmPDhiaB?= NVHTVXZFVG:pIFfJOVA:NTdwNkGgUS=> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
NCI-H23 Mn3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XpblAvODFvMUCwJO69VQ>? NIjkUlk1QCCq M2n5Omxw\yCJSUWwQU04NjZ2IF2= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
NCI-H226 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HLSVAvODFvMUCwJO69VQ>? NHy0VmM1QCCq NH\xUIJNd2diR1m1NF0uQC52NDDN MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
NCI-H522 NXfGSWJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYKwMlAyNTFyMDFOwG0> MlO5OFghcA>? M33mR2xw\yCJSUWwQU05NjR3IF2= NHPmVZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
NCI-H438 NWDCPXNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDNXHIxNjBzLUGwNEDPxE1? MUG0PEBp MWLMc4chT0l3ME2tPE4yOSCP NGPrVlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
A549 M4\lfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPsNE4xOS1zMECg{txO NEH6SnE1QCCq MYLMc4chT0l3ME2tPE4xPyCP Ml[0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
DMS273 NITIUHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj2RlhIOC5yMT2xNFAh|ryP MXO0PEBp MYPMc4chT0l3ME2tO{45OCCP MmfTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
DMS114 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7XcIhzOC5yMT2xNFAh|ryP MYi0PEBp NY\KdlM5VG:pIFfJOVA:NThwM{mgUS=> MnnKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
LOXIMVI NUXoSWVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHEWmkxNjBzLUGwNEDPxE1? NVW1R2dIPDhiaB?= M2\ybWxw\yCJSUWwQU05NjZ4IF2= MmX6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
OVCAR3 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvFSJkxNjBzLUGwNEDPxE1? NH\2bXM1QCCq MmrGUI9oKEeLNUC9MVgvOTdiTR?= NXjJTWU5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
OVCAR4 NFTzU3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TEcFAvODFvMUCwJO69VQ>? M2T2bVQ5KGh? Mn75UI9oKEeLNUC9MVgvPThiTR?= NGfvNmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
OVCAR5 NXrkWXBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXFRpUxNjBzLUGwNEDPxE1? Mle5OFghcA>? NInWUGFNd2diR1m1NF0uPy53NzDN MmG2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
OVCAR8 Mk[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUWwMlAyNTFyMDFOwG0> M3PJNFQ5KGh? M2TRbWxw\yCJSUWwQU04Njh2IF2= NEn3c2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
SKOV3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2wMlAyNTFyMDFOwG0> NEDNVoQ1QCCq MnHVUI9oKEeLNUC9MVgvPDFiTR?= NITPbok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
RXF631L Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXIcYMxNjBzLUGwNEDPxE1? NF3EPIc1QCCq NUDqUnoyVG:pIFfJOVA:NThwMkGgUS=> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
ACHN NHrOcYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPmVW8xNjBzLUGwNEDPxE1? M2PD[VQ5KGh? NFHIfWFNd2diR1m1NF0uPy57NTDN NHS0doI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
St-4 MmKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjIc4gxNjBzLUGwNEDPxE1? NXruSGNMPDhiaB?= MkGyUI9oKEeLNUC9MVcvPDdiTR?= NEjIdpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
MKN1 M{W2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUmwMlAyNTFyMDFOwG0> MlSyOFghcA>? M2TBdGxw\yCJSUWwQU05NjRzIF2= NV2ydYN4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
MKN7 M{iwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXKwMlAyNTFyMDFOwG0> M{W1O|Q5KGh? M1v4VWxw\yCJSUWwQU04NjZ6IF2= M1TRdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
MKN28 NUTLW5N2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfRWotVOC5yMT2xNFAh|ryP M3fzZlQ5KGh? MWjMc4chT0l3ME2tO{4xPyCP M4HCRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
MKN45 NFP2RmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV:wMlAyNTFyMDFOwG0> MUW0PEBp NV7weVY5VG:pIFfJOVA:NThwM{SgUS=> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
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Trypanosoma brucei brucei NGrNO2lHfW6ldHnvckBCe3OjeR?= Mn\zNlAxKG6P MWSxNkBp M13NcmROW09? Ml3DSYZn\WO2IH;uJJNxcGmwZ3;tfYxmcW5ibHX2[Yw> MlfnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6MEW5OFYoRjJ2OEC1PVQ3RC:jPh?=
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MKN1 NGTIWYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[2TWM2OD1{Lkigcm0> NH\PSlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
NCI-H720 NVrQd|VNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrnTWM2OD1|LkW3JI5O M1rwd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
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BPH-1 M2L5bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHjWVlqUUN3ME20Mlc3KG6P NX\WfXZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
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AN3-CA NHXZXGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2L0TmlEPTB;NT61OkBvVQ>? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
HN NEXVTVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLmTWM2OD13Lkm2JI5O MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
HCC2218 M3HSU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTZwNkGgcm0> NUf1bZdSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
KP-4 NHTW[ZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLHdpZKSzVyPUegcm0> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
LU-139 M1jXd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWG0TXF[UUN3ME23Mlc4KG6P M4PHPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
ETK-1 M2jkRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjwdolwUUN3ME23Mlg5KG6P Ml64QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
Ramos-2G6-4C10 M2XKeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXrTWM2OD16LkS5JI5O M3X5[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
MHH-PREB-1 M3nXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T2NGlEPTB;OT6xNkBvVQ>? NGPuOZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
DU-4475 MoPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnu4TWM2OD17LkS0JI5O MkLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
NCI-H1666 NV;OZmRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDLTVRKSzVyPUmuO|Ehdk1? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
CAMA-1 Mn33S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPPZZo{UUN3ME25Mlghdk1? NFnvdmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
TYK-nu M4XhTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTlwOUSgcm0> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
MFE-280 MmPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fNNWlEPTB;OT65PUBvVQ>? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
A549 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTFyLkG0JI5O M{i0NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
769-P M1e3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULJN5dEUUN3ME2xNE41PCCwTR?= NGPXXYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
L-363 M1;0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\ITWM2OD1zMD62PUBvVQ>? M4LFOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
ES8 MkXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fXW2lEPTB;MUCuPUBvVQ>? NVfsTJhDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
PA-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPFTWM2OD1zMT64NkBvVQ>? NHS2e4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
Mewo MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGG0VGNKSzVyPUGxMlk6KG6P MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
HSC-3 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r1UWlEPTB;MUKuNlEhdk1? NF;DO5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
H4 NUDTWIdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3njR2lEPTB;MUKuOlchdk1? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
BB65-RCC M1Lae2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXmTWM2OD1zMj63NkBvVQ>? M2XhUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
NCI-H1793 NVTTUZltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFWx[|JKSzVyPUGyMlgzKG6P MmfaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
KARPAS-45 NGfvS|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1r1fmlEPTB;MUOuOVEhdk1? MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
GCT M37NT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7pTWM2OD1zMz62PEBvVQ>? NU\G[2ZWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
EoL-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTF|LkmzJI5O M4TVNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
LB2241-RCC NHr2OWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LERWlEPTB;MUSuNFEhdk1? M1\zUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
ES5 NIDHeXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\KOmlEPTB;MUSuO|Qhdk1? M33ZXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
LOXIMVI MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnGfnVKSzVyPUG0Mlk6KG6P MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
COR-L105 Mo\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF3LkC0JI5O MkTSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
P12-ICHIKAWA NIDaSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zTUWlEPTB;MUWuNUBvVQ>? Mkf3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
CHL-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HFdmlEPTB;MUWuOFUhdk1? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
VMRC-RCZ MkHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfGRVRKSzVyPUG1MlY{KG6P M2S3eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
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