Dactolisib (BEZ235)

For research use only. Not for use in humans.

目录号:S1009 别名: NVP-BEZ235 中文名称:达克利司

Dactolisib (BEZ235) Chemical Structure

CAS No. 915019-65-7

Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Dactolisib可诱导自噬并抑制HIV-1的复制。Phase 2。

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客户使用Selleck生产的Dactolisib (BEZ235)发表文献375篇:

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3KmTOR 抑制剂,在无细胞试验中,抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR,IC50 为 21 nM,而对 Akt 和 PDK1 的抑制作用很弱。Dactolisib可诱导自噬并抑制HIV-1的复制。Phase 2。
靶点
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
体外研究

BEZ235显著降低mTOR活化的激酶p70S6K的磷酸化水平。BEZ235导致S235/S236P-RPS6水平减少,IC50为6.5 nM。BEZ235抗mTOR的活性使用生化mTOR K-LISA试验测定,IC50为20.7 nM。BEZ235对其β旁系同源物的活性稍弱,IC50为75 nM。在人肿瘤细胞中,PI3K/Akt/mTOR通路经常被组成性活化。BEZ235阻断PI3K和mTOR激酶活性,通过结合于这些酶的ATP结合槽发挥作用。用逐渐增加浓度BEZ235处理PTEN-null细胞系PC3M和U87MG时,导致细胞增殖剂量依赖性减少,平均GI50为10-12 nM。[1] BEZ235是一种mTORC1/2催化抑制剂。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei M3rDUmFvfGmvaXPyc4Jq[WxiQYPzZZk> MV:xPEBp M17RbmROW09? NETLZWRCdnSrdIL5dIFvd3OxbXHsJIFkfGm4aYT5JJdqfGhiRVO1NEBw\iByLkCwNlUh|ryP MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhyNUm0Okc,OjR6MEW5OFY9N2F-
MCF7 MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jFT|AvODFvMUCwJO69VQ>? MXu0PEBp MmHUSG1UVw>? MVHJR|UxRTBwN{Og{txO MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh5MUmwOEc,OjN6N{G5NFQ9N2F-
HCT116 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTFdJh[OC5yMT2xNFAh|ryP MWK0PEBp M1zwZmROW09? MXjJR|UxRTFwMU[g{txO NYLjTWhLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4O|E6ODRpPkKzPFcyQTB2PD;hQi=>
U87MG M{C2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3GRmJJOC5yMT2xNFAh|ryP M{DjW|Q5KGh? M4jmOGROW09? MkLYTWM2OD1zLkOyJO69VQ>? NH30NJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i3NVkxPCd-MkO4O|E6ODR:L3G+
HBC4 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWewMlAyNTFyMDFOwG0> NIHqd|g1QCCq NFXPO2NNd2diR1m1NF0uQC54MTDN NHX5OFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
BSY1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLmNE4xOS1zMECg{txO NYHFbJk2PDhiaB?= NGjxSHVNd2diR1m1NF0uQC52ODDN NXzHPFUyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
HBC5 NXXlbWJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjQNE4xOS1zMECg{txO M1rH[lQ5KGh? M2HRTWxw\yCJSUWwQU04Njh5IF2= M3SwSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
MCF7 MonWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVSwMlAyNTFyMDFOwG0> M4LLUVQ5KGh? M1jiUmxw\yCJSUWwQU05NjF4IF2= NULkeWFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
MDA-MB-231 NFTYeWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M322cVAvODFvMUCwJO69VQ>? NVjJWYRrPDhiaB?= MWPMc4chT0l3ME2tPE4xQSCP Mn7LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
U251 Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDZfYE3OC5yMT2xNFAh|ryP M{jF[FQ5KGh? NUjhd3Q{VG:pIFfJOVA:NTdwNk[gUS=> NGi1UXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
SF268 MoHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX2bYxoOC5yMT2xNFAh|ryP MWO0PEBp MlrqUI9oKEeLNUC9MVcvQTJiTR?= NIX3UG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
SF295 NInHXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHHNE4xOS1zMECg{txO NWjiO5RCPDhiaB?= M2D2S2xw\yCJSUWwQU05NjNzIF2= M3\Ub|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
SF539 NHf3SWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH4SXAxNjBzLUGwNEDPxE1? NFnaNFg1QCCq M{nTd2xw\yCJSUWwQU05NjV7IF2= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
SNB75 MkXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDER5o5OC5yMT2xNFAh|ryP NXPs[FhLPDhiaB?= NFjhV|lNd2diR1m1NF0uQC53ODDN NUP0dpB5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
SNB78 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHZNE4xOS1zMECg{txO NGXjb5Y1QCCq NYXVWFdpVG:pIFfJOVA:NThwNkWgUS=> M1n3ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
HCC2998 NHG3XpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fY[|AvODFvMUCwJO69VQ>? NWjLdYc2PDhiaB?= MmXMUI9oKEeLNUC9MVgvODViTR?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
KM12 M{fTVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\6NE4xOS1zMECg{txO NFLzfXM1QCCq NGLXcoFNd2diR1m1NF0uPy53NDDN MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
HT-29 NIDicnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX[wMlAyNTFyMDFOwG0> NUDZe4hSPDhiaB?= Mn3nUI9oKEeLNUC9MVcvPzViTR?= NUjkdm1VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
HCT15 NXHxNFNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWSwMlAyNTFyMDFOwG0> NXLCcZNzPDhiaB?= MWDMc4chT0l3ME2tPE4xOyCP M1v3S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
HCT116 NV\IemFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LMPVAvODFvMUCwJO69VQ>? M3jaNVQ5KGh? MlfzUI9oKEeLNUC9MVcvPjFiTR?= M2f1OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
NCI-H23 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVWyUpI1OC5yMT2xNFAh|ryP MmKyOFghcA>? NGezO4xNd2diR1m1NF0uPy54NDDN NXj1VI1vRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
NCI-H226 NUXY[m1lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[wMlAyNTFyMDFOwG0> NELIdGI1QCCq MWXMc4chT0l3ME2tPE41PCCP MlnFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
NCI-H522 NGDhZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGC2dJAxNjBzLUGwNEDPxE1? NXvs[2p6PDhiaB?= NWO4SpZxVG:pIFfJOVA:NThwNEWgUS=> MnLyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
NCI-H438 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HteVAvODFvMUCwJO69VQ>? M{P6NFQ5KGh? MWHMc4chT0l3ME2tPE4yOSCP M3;GVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
A549 NUW2RnpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXT0O2ppOC5yMT2xNFAh|ryP MmGwOFghcA>? M1vneGxw\yCJSUWwQU05NjB5IF2= NX7Ec4QzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
DMS273 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XiTlAvODFvMUCwJO69VQ>? M{f6OFQ5KGh? MVfMc4chT0l3ME2tO{45OCCP M1r0flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
DMS114 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoWyNE4xOS1zMECg{txO NV7RWndPPDhiaB?= MVfMc4chT0l3ME2tPE4{QSCP NXTrcllWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
LOXIMVI MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDRVZExNjBzLUGwNEDPxE1? NULU[GpYPDhiaB?= MmryUI9oKEeLNUC9MVgvPjZiTR?= Mn:wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
OVCAR3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVSwMlAyNTFyMDFOwG0> MnGxOFghcA>? M{PQfWxw\yCJSUWwQU05NjF5IF2= NHrzWW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
OVCAR4 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnNNosxNjBzLUGwNEDPxE1? NUPTOIM5PDhiaB?= M{fIcmxw\yCJSUWwQU05NjV6IF2= NGfRUmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
OVCAR5 MmDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWSwMlAyNTFyMDFOwG0> NGnDcYw1QCCq MnzQUI9oKEeLNUC9MVcvPTdiTR?= NXq0bXBkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
OVCAR8 NF;B[otIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXwZ|JNOC5yMT2xNFAh|ryP NYDKbXVqPDhiaB?= NVvIdYk1VG:pIFfJOVA:NTdwOESgUS=> NYLRS|JHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
SKOV3 NHO5[4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHBNE4xOS1zMECg{txO NHv5NVE1QCCq MYXMc4chT0l3ME2tPE41OSCP MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
RXF631L M{jTW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrVeFJkOC5yMT2xNFAh|ryP MWS0PEBp M4HtU2xw\yCJSUWwQU05NjJzIF2= Mn\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
ACHN M4e3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW[wMlAyNTFyMDFOwG0> NFWwN2I1QCCq MUXMc4chT0l3ME2tO{46PSCP MkPzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
St-4 M4f6bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DBVFAvODFvMUCwJO69VQ>? MoT3OFghcA>? MWjMc4chT0l3ME2tO{41PyCP NVLlWoNlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
MKN1 NYP3[ZBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfqNE4xOS1zMECg{txO MkP1OFghcA>? NVK3eXNqVG:pIFfJOVA:NThwNEGgUS=> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
MKN7 M4m5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYSwMlAyNTFyMDFOwG0> NGLySI41QCCq NHLid3pNd2diR1m1NF0uPy54ODDN NE\kUJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
MKN28 NVXnc4hmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWGwMlAyNTFyMDFOwG0> MXm0PEBp NUTCW4RtVG:pIFfJOVA:NTdwMEegUS=> NVTCU5RqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
MKN45 M2HoXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXWwMlAyNTFyMDFOwG0> M3rSfFQ5KGh? Ml\pUI9oKEeLNUC9MVgvOzRiTR?= NH33RXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
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DU145 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PSfVAvODFvMUCwJO69VQ>? MmTQOFghcA>? MVHMc4chT0l3ME2tPE4yPiCP MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
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ETK-1 MnX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHTcXlKSzVyPUeuPFghdk1? NHqzfJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
Ramos-2G6-4C10 M2DUNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLlTWM2OD16LkS5JI5O MmnnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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DU-4475 NHvsdI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInDUo1KSzVyPUmuOFQhdk1? NEXuT|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
NCI-H1666 NG\uWYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTlwN{Ggcm0> NYn5[IQ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
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A549 NYXsWVNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVS1dYxCUUN3ME2xNE4yPCCwTR?= Mn3vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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L-363 M1y5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrE[XJrUUN3ME2xNE43QSCwTR?= M3\4e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
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PA-1 M3;SW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3uyPWlEPTB;MUGuPFIhdk1? NVvURmxuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
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HSC-3 NXfQZ5V4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXHe4RKSzVyPUGyMlIyKG6P NI\LNJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
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BB65-RCC M2PLeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTF{LkeyJI5O M3rzNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
NCI-H1793 M1XKSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HTTWlEPTB;MUKuPFIhdk1? MkTRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
KARPAS-45 NF7DdYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXBNIJ{UUN3ME2xN{42OSCwTR?= MnHXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
GCT MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTF|Lk[4JI5O NEDOd4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
EoL-1 M{HVVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4e0WmlEPTB;MUOuPVMhdk1? NGfjdVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
LB2241-RCC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LWdmlEPTB;MUSuNFEhdk1? NF3LTow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
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COR-L105 NVHQTGZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:1TWM2OD1zNT6wOEBvVQ>? NXHYSHppRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
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