Dactolisib (BEZ235, NVP-BEZ235)

目录号：S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3K 和 mTOR 抑制剂，在无细胞试验中，抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR，IC50 为 21 nM，而对 Akt 和 PDK1 的抑制作用很弱。Phase 2。

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RMB 895.88 现货
RMB 1414.41 现货
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客户使用Selleck该产品发表文献88篇：

客户使用该产品的11个实验数据：

  • Level of phospho-proteins in RTK and PI3K–Akt–mTOR pathways in treated tumours, detected with western blot.

    Nature, 2017, 728-732. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • (B) The effects of AZD2014, BEZ235, lapatinib, LEE011, pazopanib on PI3K/AKT signaling in sarcoma PDC line were determined by immunoblotting analysis. Cells were treated with 1 μM of the indicated drugs for 72 h.

    Transl Oncol, 2016, 9(3):197-202. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    The effects of LY294002, rapamycin and NVP-BEZ235 on activation of PI3K-Akt-mTOR pathway in hepatocytes. (a) The mRNA expression (PI3K, Akt, mTOR, raptor) by Real-Time PCR, (b) protein expression (PI3K, Akt, mTOR, S6K) by ELISA kits; (c) protein expression of S6K and P-S6K by western blotting. The different letters indicated significant differences (P <0.05). LY = LY294002; rapa = rapamycin; NVP = NVP-BEZ235.

    Animal, 2016, 10(8):1319-27. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Dactolisib (BEZ235, NVP-BEZ235) 是一种双重ATP竞争性 PI3K 和 mTOR 抑制剂，在无细胞试验中，抑制 p110α/γ/δ/β 和 mTOR(p70S6K) 的 IC50 分别为 4 nM /5 nM /7 nM /75 nM /6 nM。 在 3T3TopBP1-ER 细胞中抑制 ATR，IC50 为 21 nM，而对 Akt 和 PDK1 的抑制作用很弱。Phase 2。
靶点
p110α [1]
(Cell-free assay)		 p110γ [1]
(Cell-free assay)		 mTOR (p70S6K) [1]
(Cell-free assay)		 p110δ [1]
(Cell-free assay)		 ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
体外研究

BEZ235显著降低mTOR活化的激酶p70S6K的磷酸化水平。BEZ235导致S235/S236P-RPS6水平减少，IC50为6.5 nM。BEZ235抗mTOR的活性使用生化mTOR K-LISA试验测定，IC50为20.7 nM。BEZ235对其β旁系同源物的活性稍弱，IC50为75 nM。在人肿瘤细胞中，PI3K/Akt/mTOR通路经常被组成性活化。BEZ235阻断PI3K和mTOR激酶活性，通过结合于这些酶的ATP结合槽发挥作用。用逐渐增加浓度BEZ235处理PTEN-null细胞系PC3M和U87MG时，导致细胞增殖剂量依赖性减少，平均GI50为10-12 nM。[1] BEZ235是一种mTORC1/2催化抑制剂。[2]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MV3BcpRqdWmlcn;ibYFtKEG|c3H5 MX6xPEBp M33GNmROW09? NUDhSow5SW62aYTyfZBidm:|b33hcEBi[3Srdnn0fUB4cXSqIFXDOVAhd2ZiMD6wNFI2KM7:TR?= NFu2d3ozPDhyNUm0Oi=>
MCF7 NX;lN3pmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHFNE4xOS1zMECg{txO MYq0PEBp NV3TNoZmTE2VTx?= NUHDVYh6UUN3ME2wMlc{KM7:TR?= MnvmNlM5PzF7MES=
HCT116 NIDkWItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfxSnUxNjBzLUGwNEDPxE1? NGHVS|Q1QCCq MkfzSG1UVw>? NEDoemJKSzVyPUGuNVYh|ryP NUPFXFRHOjN6N{G5NFQ>
U87MG NFXmSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[0NE4xOS1zMECg{txO MXu0PEBp NF7FZ29FVVOR NHixcHFKSzVyPUGuN|Ih|ryP MnHoNlM5PzF7MES=
HBC4 M1\POWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M124S|AvODFvMUCwJO69VQ>? M3HLT|Q5KGh? M2\kO2xw\yCJSUWwQU05NjZzIF2= M4DzTFIzOzN4MkS2
BSY1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIr2VXExNjBzLUGwNEDPxE1? NI[3U5U1QCCq M4S1cGxw\yCJSUWwQU05NjR6IF2= M1X5cFIzOzN4MkS2
HBC5 NYX1[WdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPKOmMxNjBzLUGwNEDPxE1? M2TtPFQ5KGh? NVTBbYFwVG:pIFfJOVA:NTdwOEegUS=> MkDnNlI{OzZ{NE[=
MCF7 NV6xNWVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP3NmgxNjBzLUGwNEDPxE1? MVO0PEBp NET1XYpNd2diR1m1NF0uQC5zNjDN MX:yNlM{PjJ2Nh?=
MDA-MB-231 M1WzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLyNE4xOS1zMECg{txO MoCxOFghcA>? MXrMc4chT0l3ME2tPE4xQSCP NWDhZYpwOjJ|M{[yOFY>
U251 NHizV|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7yV4t{OC5yMT2xNFAh|ryP MVq0PEBp M4LjbGxw\yCJSUWwQU04NjZ4IF2= NFvFPZczOjN|NkK0Oi=>
SF268 MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLjRlVoOC5yMT2xNFAh|ryP MlO2OFghcA>? MV;Mc4chT0l3ME2tO{46OiCP Mn:xNlI{OzZ{NE[=
SF295 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnydoxHOC5yMT2xNFAh|ryP MlrTOFghcA>? MWjMc4chT0l3ME2tPE4{OSCP MY[yNlM{PjJ2Nh?=
SF539 M1voXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWqwMlAyNTFyMDFOwG0> NYPzVFZWPDhiaB?= MmjIUI9oKEeLNUC9MVgvPTliTR?= NFHLcXAzOjN|NkK0Oi=>
SNB75 M13hWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3BNE4xOS1zMECg{txO NVTSSFV6PDhiaB?= MX7Mc4chT0l3ME2tPE42QCCP MmjRNlI{OzZ{NE[=
SNB78 MlXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXTVGVlOC5yMT2xNFAh|ryP MoT4OFghcA>? NXu5W4hVVG:pIFfJOVA:NThwNkWgUS=> Mm\3NlI{OzZ{NE[=
HCC2998 Mke4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT2VHF6OC5yMT2xNFAh|ryP MYK0PEBp M3vYZ2xw\yCJSUWwQU05NjB3IF2= NXH2NGlGOjJ|M{[yOFY>
KM12 NVnFT2FXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDHNE4xOS1zMECg{txO MVm0PEBp MWnMc4chT0l3ME2tO{42PCCP MXWyNlM{PjJ2Nh?=
HT-29 NV6wO3N{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPCbIwxNjBzLUGwNEDPxE1? NYWySGlvPDhiaB?= NETDPY5Nd2diR1m1NF0uPy55NTDN MV2yNlM{PjJ2Nh?=
HCT15 NXvROWtrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjSZ2kxNjBzLUGwNEDPxE1? NHXDbWU1QCCq MYDMc4chT0l3ME2tPE4xOyCP MYGyNlM{PjJ2Nh?=
HCT116 NGX0cVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\keFAvODFvMUCwJO69VQ>? NV30U3B3PDhiaB?= M1K0WGxw\yCJSUWwQU04NjZzIF2= NGTBbWczOjN|NkK0Oi=>
NCI-H23 M3fFSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\Pb|NKOC5yMT2xNFAh|ryP MWS0PEBp MomzUI9oKEeLNUC9MVcvPjRiTR?= NVniWo9wOjJ|M{[yOFY>
NCI-H226 NFjHTIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rJR|AvODFvMUCwJO69VQ>? MXK0PEBp MYXMc4chT0l3ME2tPE41PCCP Mmr0NlI{OzZ{NE[=
NCI-H522 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki5NE4xOS1zMECg{txO NFnoXW01QCCq MnX4UI9oKEeLNUC9MVgvPDViTR?= M4OxR|IzOzN4MkS2
NCI-H438 M{fLZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS4XZExNjBzLUGwNEDPxE1? M2nGRVQ5KGh? M3TYOmxw\yCJSUWwQU05NjFzIF2= NFyyWIMzOjN|NkK0Oi=>
A549 NVSwXYhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3CeVkxNjBzLUGwNEDPxE1? NVu3UIMyPDhiaB?= M2ryTGxw\yCJSUWwQU05NjB5IF2= MXKyNlM{PjJ2Nh?=
DMS273 NVj4WYlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTXXo1lOC5yMT2xNFAh|ryP M173T|Q5KGh? MoWyUI9oKEeLNUC9MVcvQDBiTR?= MYWyNlM{PjJ2Nh?=
DMS114 MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3oNE4xOS1zMECg{txO MWK0PEBp MXjMc4chT0l3ME2tPE4{QSCP NHzw[YozOjN|NkK0Oi=>
LOXIMVI M1vEW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fMXFAvODFvMUCwJO69VQ>? NIi3XXg1QCCq M2W1TWxw\yCJSUWwQU05NjZ4IF2= NHLqS3AzOjN|NkK0Oi=>
OVCAR3 NW\hSXpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3SfmwxNjBzLUGwNEDPxE1? MojlOFghcA>? NH3mdYFNd2diR1m1NF0uQC5zNzDN M135N|IzOzN4MkS2
OVCAR4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2exdFAvODFvMUCwJO69VQ>? MkH3OFghcA>? NUHrZng6VG:pIFfJOVA:NThwNUigUS=> NUnZcVlVOjJ|M{[yOFY>
OVCAR5 NHm4cZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWOwMlAyNTFyMDFOwG0> MlTBOFghcA>? NV3BS2dtVG:pIFfJOVA:NTdwNUegUS=> M4jRSFIzOzN4MkS2
OVCAR8 NWrjeoNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[wMlAyNTFyMDFOwG0> NXu0NoE5PDhiaB?= NFvhdJdNd2diR1m1NF0uPy56NDDN M1PNSFIzOzN4MkS2
SKOV3 NEHpeYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWGwMlAyNTFyMDFOwG0> NFvjcXI1QCCq NWXsOnNIVG:pIFfJOVA:NThwNEGgUS=> Mn3QNlI{OzZ{NE[=
RXF631L M1vuT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInqOo8xNjBzLUGwNEDPxE1? NHTaUlk1QCCq M1PYXmxw\yCJSUWwQU05NjJzIF2= M4G1UlIzOzN4MkS2
ACHN M3TCRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDuSWoxNjBzLUGwNEDPxE1? NVXuRXVHPDhiaB?= MWjMc4chT0l3ME2tO{46PSCP NUjTbW9iOjJ|M{[yOFY>
St-4 NXLhc24xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHru[5IxNjBzLUGwNEDPxE1? MVO0PEBp MXXMc4chT0l3ME2tO{41PyCP M2H4ZVIzOzN4MkS2
MKN1 M3voWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH2NE4xOS1zMECg{txO NXvrUolUPDhiaB?= M3LXeWxw\yCJSUWwQU05NjRzIF2= Mn:5NlI{OzZ{NE[=
MKN7 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO5PZlqOC5yMT2xNFAh|ryP M3fkNlQ5KGh? Mlm0UI9oKEeLNUC9MVcvPjhiTR?= NWW1RZhIOjJ|M{[yOFY>
MKN28 M{W2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\leoIxNjBzLUGwNEDPxE1? NViyZmJ1PDhiaB?= MVXMc4chT0l3ME2tO{4xPyCP NW\yfWdrOjJ|M{[yOFY>
MKN45 M{fzeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXGwMlAyNTFyMDFOwG0> NV\VO|JRPDhiaB?= MXTMc4chT0l3ME2tPE4{PCCP Ml[4NlI{OzZ{NE[=
MKN74 NX;XcoUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXX3b3BLOC5yMT2xNFAh|ryP MV20PEBp NY\TWolWVG:pIFfJOVA:NTdwNEKgUS=> NV;LSVdqOjJ|M{[yOFY>
DU145 M4DaXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTRNE4xOS1zMECg{txO NEHEVHk1QCCq Mlu1UI9oKEeLNUC9MVgvOTZiTR?= M2LXZ|IzOzN4MkS2
PC3 M3:4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjBNE4xOS1zMECg{txO M1fSb|Q5KGh? MlvIUI9oKEeLNUC9MVgvPjZiTR?= M13Ce|IzOzN4MkS2
Trypanosoma brucei brucei M{HY[WZ2dmO2aX;uJGF{e2G7 NVPESGp{OjByIH7N NWTmPHVmOTJiaB?= NH\J[|FFVVOR NIjudVBF\WO{ZXHz[UBqdiCyaH;zdIhwfGmmeXygbY5we2m2b3ygdIhwe3CqYYTlJIxmfmWu MXKyOFgxPTl2Nh?=
Trypanosoma brucei brucei M1ju[GZ2dmO2aX;uJGF{e2G7 M2XOO|E5KGh? M{i0UmROW09? MVrJcohq[mm2aX;uJI9nKHKnY3XweI9zNW2nZHnheIVlKGWwZH;jfZRwe2m|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHS{YX7z[oVzemmwIIXweIFs\Q>? MVKyOFgxPTl2Nh?=
Trypanosoma brucei brucei NWjQOVUyTnWwY4Tpc44hSXO|YYm= NVjZZW5JOjByIH7N MnT3NVIhcA>? NH7YS5FFVVOR MoL5SYZn\WO2IH;uJJNxcGmwZ3;tfYxmcW5ibHX2[Yw> Ml;PNlQ5ODV7NE[=
Trypanosoma brucei brucei M4rsPWZ2dmO2aX;uJGF{e2G7 NV\pNocyOjByIH7N MlLSNVIhcA>? NWTNcndKTE2VTx?= NXnyO2VoTW[oZXP0JI9vKHCqb4PwbIF1cWS7bHPoc4xqdmVibHX2[Yw> NG\GSG0zPDhyNUm0Oi=>
UM-UC-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\OZYpEUUN3ME2zNVUheE1? NWj0TFRLW0GQR1XS
SBC-1 M2rtcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPmTWM2OD15NEKgdG0> NIrVT2hUSU6JRWK=
MKN1 NUnxTZpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4iy[GlEPTB;Mj64JI5O NWXvW5dqW0GQR1XS
NCI-H720 NYXaSZJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDOTWM2OD1|LkW3JI5O NGrpc|FUSU6JRWK=
BFTC-909 M{TNT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr3V|dKSzVyPUOuO|Ehdk1? M3XESXNCVkeHUh?=
BPH-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHhc2h[UUN3ME20Mlc3KG6P MmDHV2FPT0WU
PC-3 M16xeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvVS3VKSzVyPUWuNFkhdk1? NHHnUFRUSU6JRWK=
AN3-CA MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTVwNU[gcm0> M2\mV3NCVkeHUh?=
HN MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XWWGlEPTB;NT65OkBvVQ>? NUCxd5NOW0GQR1XS
HCC2218 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTZwNkGgcm0> NHnIfIhUSU6JRWK=
KP-4 M3PxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\B[GlEPTB;NzDuUS=> NXr1eol3W0GQR1XS
LU-139 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\5NYZSUUN3ME23Mlc4KG6P M3u1UHNCVkeHUh?=
ETK-1 NH3JT3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTdwOEigcm0> MXHTRW5ITVJ?
Ramos-2G6-4C10 NGP0dZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRThwNEmgcm0> NIPENZRUSU6JRWK=
MHH-PREB-1 MnXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\kfGlEPTB;OT6xNkBvVQ>? MmX3V2FPT0WU
DU-4475 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfpfZo{UUN3ME25MlQ1KG6P MlvxV2FPT0WU
NCI-H1666 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIG4TXFKSzVyPUmuO|Ehdk1? MWDTRW5ITVJ?
CAMA-1 M4XRXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTaTWM2OD17Lkigcm0> NG\hWlZUSU6JRWK=
TYK-nu NUOye21TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVP1fZlpUUN3ME25Mlk1KG6P MVfTRW5ITVJ?
MFE-280 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvLSZdDUUN3ME25Mlk6KG6P NXH4NI9HW0GQR1XS
A549 M{mxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;JRVJKSzVyPUGwMlE1KG6P NFfOdmJUSU6JRWK=
769-P M3\NTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe5eZhYUUN3ME2xNE41PCCwTR?= M{XFZXNCVkeHUh?=
L-363 NUjtbnROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1THTmlEPTB;MUCuOlkhdk1? M4r5OnNCVkeHUh?=
ES8 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTITWM2OD1zMD65JI5O NIW4RmJUSU6JRWK=
PA-1 NEjycYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPiRo5KSzVyPUGxMlgzKG6P NGn5[ppUSU6JRWK=
Mewo MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\2b2lEPTB;MUGuPVkhdk1? MmPXV2FPT0WU
HSC-3 M1LsdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHLcINKSzVyPUGyMlIyKG6P Mnz5V2FPT0WU
H4 NVK2[4ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjvTWM2OD1zMj62O{BvVQ>? NGf3fYZUSU6JRWK=
BB65-RCC M1XIcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF{LkeyJI5O MmHGV2FPT0WU
NCI-H1793 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DMOGlEPTB;MUKuPFIhdk1? Ml\wV2FPT0WU
KARPAS-45 M4Lze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3W0eGlEPTB;MUOuOVEhdk1? M1PDbnNCVkeHUh?=
GCT M{TWVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTBTWM2OD1zMz62PEBvVQ>? NUTxPFlJW0GQR1XS
EoL-1 M1zkNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTF|LkmzJI5O NUXiOGJsW0GQR1XS
LB2241-RCC MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDrTWM2OD1zND6wNUBvVQ>? NFHyTohUSU6JRWK=
ES5 MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPzOHNVUUN3ME2xOE44PCCwTR?= NV3nXIl5W0GQR1XS
LOXIMVI M1:5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW0dpQ6UUN3ME2xOE46QSCwTR?= MWfTRW5ITVJ?
COR-L105 NELGXIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHsOnJKSzVyPUG1MlA1KG6P M2TY[HNCVkeHUh?=
P12-ICHIKAWA MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnrTW1RUUN3ME2xOU4yKG6P MmL6V2FPT0WU
CHL-1 MnL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLNOW1ZUUN3ME2xOU41PSCwTR?= MUfTRW5ITVJ?
VMRC-RCZ NWXzenNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LkPGlEPTB;MUWuOlMhdk1? MV\TRW5ITVJ?
HH NYrGOFdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTF3Lkegcm0> NWDDWYZ2W0GQR1XS
NUGC-3 M2njemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHva[JVKSzVyPUG2MlM1KG6P MX\TRW5ITVJ?
EGI-1 M{\JWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXsTWM2OD1zNj60N{BvVQ>? M{nhZnNCVkeHUh?=
OS-RC-2 NIjxUFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGi1[o5KSzVyPUG2MlQ4KG6P M1vMUnNCVkeHUh?=
MOLT-16 MmLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjIZ|cxUUN3ME2xO{4yPSCwTR?= MmLMV2FPT0WU
NCI-H209 NG\ucVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInTc2RKSzVyPUG3MlI6KG6P M2nuUHNCVkeHUh?=
697 MnnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTF5LkSzJI5O NIjCe5lUSU6JRWK=
D-56MG Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\iTWM2OD1zNz62PUBvVQ>? NYrMNWd{W0GQR1XS
VA-ES-BJ MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvsNGJjUUN3ME2xO{45OyCwTR?= M1rQTHNCVkeHUh?=
EW-16 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHjcGdXUUN3ME2xPE4xPCCwTR?= MmnPV2FPT0WU
HGC-27 NIjwOJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTF6LkC2JI5O MVzTRW5ITVJ?
ES7 MmrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfpWIR1UUN3ME2xPE4xQSCwTR?= NVXIfZluW0GQR1XS
HuH-7 NYfUboZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEGzd2FKSzVyPUG4MlQhdk1? MWXTRW5ITVJ?
BCPAP NVflNo5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGntcVVKSzVyPUG4MlY2KG6P MXjTRW5ITVJ?
SW1710 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHhTWM2OD1zOD63NkBvVQ>? NXTTZm9yW0GQR1XS
IST-MEL1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHtNFlKSzVyPUG4Mlc4KG6P NX\oPXRTW0GQR1XS
SF295 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DmUmlEPTB;MUiuPVMhdk1? M2fXTHNCVkeHUh?=
RPMI-7951 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTF7LkK4JI5O M3PpcHNCVkeHUh?=
SF126 MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTF7LkSxJI5O NHrubIJUSU6JRWK=
GAMG NV;6eW96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTF7LkS4JI5O MlGwV2FPT0WU
KNS-81-FD NELUboZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\NPGRxUUN3ME2xPU42PCCwTR?= M3[1OnNCVkeHUh?=
RT-112 M{nnVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLMToxZUUN3ME2xPU43PiCwTR?= M2m1THNCVkeHUh?=
DEL M1qxUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLueJZzUUN3ME2yNE41QSCwTR?= MonmV2FPT0WU
CGTH-W-1 M4TBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzKc|VIUUN3ME2yNE43OyCwTR?= NXOwU5hlW0GQR1XS
HOS MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml:3TWM2OD1{MT6wOkBvVQ>? M1zobXNCVkeHUh?=
ES4 MnjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWO4T4d5UUN3ME2yNU4xQCCwTR?= NFK4SW9USU6JRWK=
RXF393 M4G0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf6TWM2OD1{MT60OUBvVQ>? MY\TRW5ITVJ?
NCI-H2030 NHfBO4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGftUpBKSzVyPUKxMlUzKG6P M3TnO3NCVkeHUh?=
YH-13 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTJzLki4JI5O NGTVO|RUSU6JRWK=
HT-1080 MkDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHI[JBrUUN3ME2yNU46OyCwTR?= M1;lPXNCVkeHUh?=
NCI-SNU-1 M{T0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1izfmlEPTB;MkGuPVUhdk1? NFzvSmZUSU6JRWK=
G-402 M3nn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLPTWM2OD1{Mj6xOkBvVQ>? NXn5UIpJW0GQR1XS
786-0 NIrHZ2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17WfmlEPTB;MkKuNlkhdk1? NU\xSZl5W0GQR1XS
ME-180 M1T0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLPTWM2OD1{Mj60N{BvVQ>? NWm2UFZjW0GQR1XS
NB69 MmPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJ{LkWzJI5O M2OyZnNCVkeHUh?=
J-RT3-T3-5 M2nPRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHGWW5PUUN3ME2yNk46PiCwTR?= MWjTRW5ITVJ?
TGBC1TKB NXnLW2lZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q1ZWlEPTB;MkOuNFUhdk1? NEPVdWdUSU6JRWK=
SW780 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ|LkGzJI5O NITKWXJUSU6JRWK=
MG-63 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXJTWM2OD1{Mz60OUBvVQ>? NW\xS4N1W0GQR1XS
BV-173 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJ|Lki3JI5O NV3QSJNPW0GQR1XS
CAL-51 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX34d4FbUUN3ME2yN{45QSCwTR?= MY\TRW5ITVJ?
A375 Mo\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFr5fWdKSzVyPUKzMlk{KG6P M4LubnNCVkeHUh?=
MEL-HO NUPHdnlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NImzfJlKSzVyPUK0MlA1KG6P MkGzV2FPT0WU
EFO-27 NFyxNopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fN[WlEPTB;MkSuN|Mhdk1? NVrIO25HW0GQR1XS
Hs-578-T NY\uXZVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rrV2lEPTB;MkSuOVghdk1? NFPG[49USU6JRWK=
NBsusSR MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ2Lk[gcm0> MWDTRW5ITVJ?
CTB-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX1eIZKSzVyPUK0MlY4KG6P M1PTWHNCVkeHUh?=
FTC-133 MoHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJ3LkGgcm0> MYfTRW5ITVJ?
MOLT-4 M3XvPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;1W2VMUUN3ME2yOU4yOiCwTR?= MnnUV2FPT0WU
HO-1-N-1 M1r4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\XdWVyUUN3ME2yOU4yPSCwTR?= M{e3OHNCVkeHUh?=
ES3 M1u1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJ3LkKyJI5O M37SNHNCVkeHUh?=
TI-73 MmjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;icppQUUN3ME2yOU4zQCCwTR?= NHn6bmpUSU6JRWK=
MPP-89 NF\VflZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDTSVdKSzVyPUK1MlMzKG6P MUfTRW5ITVJ?
KYSE-150 M3uyUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJ3Lki5JI5O M3H2PXNCVkeHUh?=
LXF-289 Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[3dZFtUUN3ME2yOk4xPCCwTR?= M2HQOHNCVkeHUh?=
SK-LU-1 Ml[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Djb2lEPTB;Mk[uNVchdk1? Mk\tV2FPT0WU
HOP-92 NWr0RmNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHQbYR5UUN3ME2yOk41QCCwTR?= NVXRTZFzW0GQR1XS
HuO9 NEHMZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTJ4Lke2JI5O NH;US3FUSU6JRWK=
SW962 M3LRdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPuTWM2OD1{Nj63OkBvVQ>? NY[zeolLW0GQR1XS
RS4-11 NGP2SFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{H3fGlEPTB;Mk[uPVEhdk1? MojYV2FPT0WU
NCI-H292 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnMW3RWUUN3ME2yO{BvVQ>? NHHVOmRUSU6JRWK=
DB M{n1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nLWmlEPTB;MkeuN|Yhdk1? NVfUWpNxW0GQR1XS
SW1088 M{H6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTtTWM2OD1{OD6yPUBvVQ>? NYSx[mVoW0GQR1XS
A204 NF7FVmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rrXWlEPTB;MkiuOFchdk1? NXH0cXM6W0GQR1XS
A3-KAW MkLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHexNYlKSzVyPUK4MlY1KG6P MXnTRW5ITVJ?
MV-4-11 MlTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7EV3NDUUN3ME2yPE44KG6P MlXiV2FPT0WU
ES1 NX\PNVd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;GeXlFUUN3ME2yPE45PCCwTR?= NXuyN4lDW0GQR1XS
ONS-76 MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzJSlJKSzVyPUK5MlA2KG6P MlrpV2FPT0WU
D-263MG M4H5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[3TWM2OD1{OT6zOUBvVQ>? MWfTRW5ITVJ?
U-2-OS M1zjcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJ7LkWgcm0> M1PEUHNCVkeHUh?=
T98G M1rTOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrRU4hKSzVyPUK5Mlg5KG6P NUnV[XRLW0GQR1XS
GI-ME-N MojYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC5TWM2OD1{OT65NUBvVQ>? M2HGO3NCVkeHUh?=
BHT-101 M3TNPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWeyUol1UUN3ME2zNE4xPSCwTR?= NIrVZ2hUSU6JRWK=
NOS-1 NYPqfodiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\Sc2psUUN3ME2zNE4yOiCwTR?= MVvTRW5ITVJ?
AsPC-1 NFPxUItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTLTWM2OD1|MD6yJI5O M4fMV3NCVkeHUh?=
QIMR-WIL NHjVeGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWwSXdKSzVyPUOwMlYhdk1? NGTxNXdUSU6JRWK=
JVM-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nQXmlEPTB;M{CuPFMhdk1? NG\zd2xUSU6JRWK=
KU-19-19 MmmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jyfWlEPTB;M{GuNVMhdk1? M4rwXXNCVkeHUh?=
OVCAR-8 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTNzLkK2JI5O NIHIfIRUSU6JRWK=
BEN NVvPZVhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTnTWM2OD1|MT62N{BvVQ>? MnfSV2FPT0WU
BE-13 MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HXTmlEPTB;M{GuPFIhdk1? M{i4UXNCVkeHUh?=
EW-18 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTNzLki2JI5O Ml3YV2FPT0WU
ECC10 Mm\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIK0OYhKSzVyPUOxMlk2KG6P NFj4U5lUSU6JRWK=
CTV-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTN{LkiyJI5O MnTJV2FPT0WU
COLO-800 Mn:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTN{LkmyJI5O NFzU[oZUSU6JRWK=
A2058 M2fBZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzSR5hsUUN3ME2zN{4zPSCwTR?= NXHhe4pKW0GQR1XS
VM-CUB-1 MofJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmqyTWM2OD1|Mz60N{BvVQ>? NHm3SGpUSU6JRWK=
Ca9-22 M2TBTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TKe2lEPTB;M{OuOVUhdk1? Ml;FV2FPT0WU
COLO-684 NI\PZopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\0TWM2OD1|Mz61PEBvVQ>? M1;4XXNCVkeHUh?=
RPMI-8226 M3\zOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DafmlEPTB;M{OuPFIhdk1? Mly3V2FPT0WU
SK-NEP-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPINnFKSzVyPUO0MlE2KG6P M3vE[nNCVkeHUh?=
Becker NYjiWIRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPQcWpSUUN3ME2zOE4zOSCwTR?= MVHTRW5ITVJ?
NCI-H28 M3fVe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTN2LkS0JI5O MVnTRW5ITVJ?
CAL-120 MmPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTN2LkeyJI5O M2W1[XNCVkeHUh?=
MDA-MB-157 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3IWnl3UUN3ME2zOU41OSCwTR?= Mn;NV2FPT0WU
OVCAR-5 NFHnZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXnZnF3UUN3ME2zOU41PyCwTR?= M1;K[XNCVkeHUh?=
LAMA-84 MorwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTNTWM2OD1|NT64O{BvVQ>? M1XQb3NCVkeHUh?=
CAKI-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXNTWM2OD1|Nj60N{BvVQ>? MoLRV2FPT0WU
Daoy MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe2[lRKSzVyPUO2Mlchdk1? NEX4[nZUSU6JRWK=
CAL-62 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zPU2lEPTB;M{[uPFYhdk1? NHTMXnpUSU6JRWK=
8-MG-BA MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTN5LkK1JI5O MX3TRW5ITVJ?
8505C NHvxOVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoezTWM2OD1|Nz61NUBvVQ>? M{\ke3NCVkeHUh?=
LNCaP-Clone-FGC M2X2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[2TWM2OD1|Nz61PUBvVQ>? NHPqeGxUSU6JRWK=
CAL-39 NHrRbJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj1SHpKSzVyPUO3Mlkhdk1? MnrnV2FPT0WU
MN-60 Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\PZWdKSzVyPUO3Mlk3KG6P NEi0ellUSU6JRWK=
RKO NEX6b3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nYT2lEPTB;M{iuN|Mhdk1? NWnYcXg6W0GQR1XS
U251 NIDwPHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[3UGlEPTB;M{iuOFMhdk1? NF33dZhUSU6JRWK=
SJSA-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XWPWlEPTB;M{iuOVQhdk1? Mo\DV2FPT0WU
CAL-12T MkSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3pZ5VKSzVyPUO4MlYhdk1? M2TqRnNCVkeHUh?=
HCC1419 M3vJRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTN6LkexJI5O MkjGV2FPT0WU
CO-314 M3PpUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7WZVdsUUN3ME2zPE44PCCwTR?= MnLXV2FPT0WU
LB1047-RCC NWDldpd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnKwTWM2OD1|OD64NUBvVQ>? NVjNfXFyW0GQR1XS
A101D NEnZT5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\RXohKSzVyPUO4Mlk4KG6P M2S1e3NCVkeHUh?=
MDA-MB-175-VII MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnkOGVwUUN3ME2zPU42OSCwTR?= MX;TRW5ITVJ?
MZ2-MEL Mn\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHMTWM2OD1|OT62OkBvVQ>? NITCS5VUSU6JRWK=
NB5 Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTRyLk[0JI5O MYXTRW5ITVJ?
G-401 MmHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vZe2lEPTB;NECuPFIhdk1? M4OzWnNCVkeHUh?=
HT MmK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTRzLkCyJI5O M4TqTXNCVkeHUh?=
8305C NYjkUWpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTRzLki3JI5O Ml7DV2FPT0WU
BHY NXnpW5RjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELtem9KSzVyPUSyMlczKG6P M1vMc3NCVkeHUh?=
NTERA-S-cl-D1 NHvSUWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvaTWM2OD12MzDuUS=> MkCxV2FPT0WU
T-24 M1Tuc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTR|LkizJI5O NELWbVFUSU6JRWK=
EPLC-272H NYG4blJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvac25bUUN3ME20OE4{QSCwTR?= M{T5UnNCVkeHUh?=
PSN1 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTR2LkSgcm0> M4GxUXNCVkeHUh?=
NCI-H2452 Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnzb4h1UUN3ME20OE42QCCwTR?= M{nD[nNCVkeHUh?=
KS-1 NXzCRmRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTR2Lk[2JI5O M4XxT3NCVkeHUh?=
HD-MY-Z MnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\wTWM2OD12ND65NkBvVQ>? NXjJT3NIW0GQR1XS
KNS-62 M{T4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nTT2lEPTB;NEWuN|ghdk1? NH7oZZZUSU6JRWK=
NOMO-1 M3eyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zTRmlEPTB;NEWuPFchdk1? MYrTRW5ITVJ?
SK-HEP-1 Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvETWM2OD12Nj6wOEBvVQ>? M{m5d3NCVkeHUh?=
IGR-1 Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfKOpBKSzVyPUS2MlE{KG6P NFjpRmlUSU6JRWK=
KYSE-180 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO3TWM2OD12Nj6xO{BvVQ>? M17RU3NCVkeHUh?=
EW-22 M4W4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTR4LkKgcm0> MmezV2FPT0WU
NCI-H1355 NI\UPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;yTWM2OD12Nj6zOEBvVQ>? MlvCV2FPT0WU
DOHH-2 M1f1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXhTWM2OD12Nj6zO{BvVQ>? MUDTRW5ITVJ?
A4-Fuk NI[yUFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTR4LkWyJI5O NXjBZpNZW0GQR1XS
PC-14 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTR4LkW3JI5O NUPTUIM1W0GQR1XS
TE-5 MoW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTR4Lki0JI5O NVjV[mxtW0GQR1XS
LB996-RCC NWHyOpl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX60Oo9zUUN3ME20O{4yQSCwTR?= MWPTRW5ITVJ?
NCI-H1623 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTR5Lke2JI5O MUfTRW5ITVJ?
NCI-H1155 NFnMTY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDIbpdzUUN3ME20PE4{OiCwTR?= NHrJb3RUSU6JRWK=
LoVo NWCxNWRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHvTWM2OD12OD60JI5O MWLTRW5ITVJ?
MCF7 MnLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPSNY5rUUN3ME20PE42QCCwTR?= NUS0V|hvW0GQR1XS
AGS NF\i[mtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHifJlkUUN3ME20PE44PyCwTR?= NF\GSYFUSU6JRWK=
PFSK-1 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nUcmlEPTB;NEmuNFYhdk1? NGH5UJBUSU6JRWK=
22RV1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDCTWM2OD12OT6wPUBvVQ>? NY\UNFZOW0GQR1XS
COR-L23 NXL3bFhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTR7LkG2JI5O MlizV2FPT0WU
D-283MED MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrvU5NKSzVyPUS5MlYyKG6P NXLCN|d6W0GQR1XS
SW982 NVXOOIdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHLd5pKSzVyPUS5MlkyKG6P NIO0UIpUSU6JRWK=
SW620 M{PsbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXvNW5IUUN3ME21NE4{PiCwTR?= Ml6zV2FPT0WU
KYSE-140 M{\r[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHyTWM2OD13MD61OUBvVQ>? MVzTRW5ITVJ?
GCIY NEPvU|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPyTHdvUUN3ME21NE43PyCwTR?= MVHTRW5ITVJ?
MHH-ESS-1 NVzyO3RyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrlVHJKSzVyPUWxMlk2KG6P NYP1W3hlW0GQR1XS
D-423MG M{LpVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrOOXJmUUN3ME21Nk4xQCCwTR?= MUTTRW5ITVJ?
SF539 MkiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWj1PWw6UUN3ME21Nk4{PSCwTR?= MlHoV2FPT0WU
RPMI-2650 Mo\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:wTWM2OD13Mj62PUBvVQ>? M4ry[nNCVkeHUh?=
GR-ST MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzMTWM2OD13Mj64O{BvVQ>? NULQSoNOW0GQR1XS
YKG-1 NYf3Uow4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfpNHNSUUN3ME21N{BvVQ>? NVvSTIxOW0GQR1XS
SK-MES-1 NH\G[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP3TWM2OD13Mz6yOkBvVQ>? NEe3dmdUSU6JRWK=
HLE M3LvXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnJW5NKSzVyPUWzMlQ4KG6P MmPjV2FPT0WU
RVH-421 M{nWe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlO1TWM2OD13Mz62O{BvVQ>? NFzpWGRUSU6JRWK=
C32 MkO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTV|LkizJI5O NY\NZpY1W0GQR1XS
GB-1 NUi4RXNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTV2LkKgcm0> MV3TRW5ITVJ?
SNB75 NHm4U4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTyWmpKSzVyPUW0MlI3KG6P Ml3ZV2FPT0WU
EM-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzuTWM2OD13ND60JI5O M1jHTXNCVkeHUh?=
RH-1 NXHuXYo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrLTWM2OD13ND63JI5O M4DWZ3NCVkeHUh?=
NKM-1 NVPnW4xVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnWTWM2OD13ND64NUBvVQ>? M3q2dHNCVkeHUh?=
NCI-H2405 NX\2b2NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3EXVNKSzVyPUW0Mlg5KG6P NI\Pfm9USU6JRWK=
KYSE-450 M2nLOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTV3LkG2JI5O NHXSZotUSU6JRWK=
A704 M1XGV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;BUZg5UUN3ME21OU42QSCwTR?= M2nJ[HNCVkeHUh?=
HAL-01 NIfrcI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TLbmlEPTB;NUWuPFMhdk1? MYDTRW5ITVJ?
TE-11 M4\vR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1y3UWlEPTB;NUWuPVkhdk1? NHPVWIhUSU6JRWK=
DOK M{G5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TzcmlEPTB;NU[uNFIhdk1? M1HpfXNCVkeHUh?=
KY821 NXvKUJZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX2wbI5PUUN3ME21Ok4zKG6P MV3TRW5ITVJ?
KGN M{[5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mly0TWM2OD13Nj6zNkBvVQ>? NIDPN4tUSU6JRWK=
MC116 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzSXGlKUUN3ME21O{45KG6P NGjE[ZBUSU6JRWK=
PANC-08-13 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInY[G9KSzVyPUW4MlAyKG6P MVXTRW5ITVJ?
KE-37 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTKOGlKSzVyPUW4Mlc4KG6P NV3ReXQ6W0GQR1XS
KYSE-410 NEDWWVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4D6W2lEPTB;NUmuOFchdk1? M3jiOnNCVkeHUh?=
RO82-W-1 NY\vTIltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mne4TWM2OD13OT65JI5O MX\TRW5ITVJ?
M14 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzrRZpKSzVyPU[wMlA1KG6P MXnTRW5ITVJ?
GI-1 MoDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlO5TWM2OD14MD6zJI5O Mmi5V2FPT0WU
ML-2 NHvI[m1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTZyLk[yJI5O NUDsOXhbW0GQR1XS
BFTC-905 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTZyLk[1JI5O NFPENpJUSU6JRWK=
DMS-273 MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXSxb4JLUUN3ME22NE45PyCwTR?= M3TqNHNCVkeHUh?=
MDA-MB-361 NEjleIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLy[|RKSzVyPU[xJI5O M3PxdHNCVkeHUh?=
MSTO-211H MlfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjNTWM2OD14Mz61NUBvVQ>? MU\TRW5ITVJ?
MEG-01 NIrZbJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDYbGtwUUN3ME22N{42OiCwTR?= M{X6NHNCVkeHUh?=
M059J M3\UU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHLTWM2OD14Mz61PEBvVQ>? MnXyV2FPT0WU
LN-405 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTZ|Lki1JI5O NFLvUpRUSU6JRWK=
NCI-H1581 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfnTWM2OD14ND6wN{BvVQ>? MVTTRW5ITVJ?
TCCSUP NIDkcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTZ2LkWzJI5O M1rGU3NCVkeHUh?=
SW872 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPJTWM2OD14ND61O{BvVQ>? NE\5RXRUSU6JRWK=
KYSE-510 MnH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DsUGlEPTB;NkWuO|Uhdk1? MlrPV2FPT0WU
NCI-H1792 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTZ4LkG1JI5O MVHTRW5ITVJ?
SW13 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\FOWlEPTB;Nk[uOUBvVQ>? NYDKRXZ1W0GQR1XS
TE-8 NXvEflRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXmeHNKSzVyPU[2MlUzKG6P MVjTRW5ITVJ?
SCH NUDifJdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzmb4tkUUN3ME22O{4yKG6P Ml6xV2FPT0WU
NEC8 M{\RR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\HZ2lEPTB;NkeuNlQhdk1? Mlq0V2FPT0WU
HuO-3N1 NF\Nb4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\WTWM2OD14Nz6zNUBvVQ>? NXfNTVlCW0GQR1XS
EFM-19 NXK2W|ZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYiycVNYUUN3ME22O{42KG6P NFvBU2RUSU6JRWK=
HEC-1 NGf0c4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3RWoZEUUN3ME22O{42OiCwTR?= NYP3NJNEW0GQR1XS
T47D NWjyWINKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkCxTWM2OD14Nz64O{BvVQ>? NGPvUpdUSU6JRWK=
SNU-423 M3\BWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTZ5Lkm4JI5O NW\jOmk{W0GQR1XS
WM-115 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWKzXJBOUUN3ME22PE4yPCCwTR?= NEHEPWFUSU6JRWK=
CaR-1 NULNd2xsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHVZpN{UUN3ME22PE4zPSCwTR?= NIi4d5lUSU6JRWK=
KU812 MkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\UU2lEPTB;NkiuOlkhdk1? NV;mUW1SW0GQR1XS
AM-38 M1;Kfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\4TWM2OD14OT6zNUBvVQ>? NHryZVlUSU6JRWK=
KOSC-2 NYn6S5pGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPwTWM2OD14OT65O{BvVQ>? NGrTZ|hUSU6JRWK=
MC-IXC NXrRPVZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTdyLkC4JI5O MYHTRW5ITVJ?
SCC-4 MnnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7TTXNCUUN3ME23NU4{QCCwTR?= M1W4W3NCVkeHUh?=
Calu-3 M1W5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;6TWM2OD15MT65PEBvVQ>? M3HpTXNCVkeHUh?=
RPMI-8866 M{\1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTd{LkiyJI5O NU\lUIM6W0GQR1XS
OVCAR-4 NVey[m1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHBOpFKSzVyPUezMlM3KG6P MYHTRW5ITVJ?
OAW-42 MlTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;sZ5hlUUN3ME23N{4{QSCwTR?= MWjTRW5ITVJ?
ATN-1 M1XlcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7WOVlKSzVyPUezMlg4KG6P M3PLU3NCVkeHUh?=
CHP-212 NUDUN2FQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTd2Lkm1JI5O NUnyOHBsW0GQR1XS
C2BBe1 M2P4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTd3LkCzJI5O NGXnfFVUSU6JRWK=
A498 MoTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTd3LkG1JI5O NY\SUIVUW0GQR1XS
SH-4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPXZpFKSzVyPUe1MlIyKG6P M{PvUnNCVkeHUh?=
SNU-449 NEfxS2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;rTWM2OD15NT63PUBvVQ>? MXTTRW5ITVJ?
RD NXrK[4pQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrMTWM2OD15NT64OkBvVQ>? NVL6OFhJW0GQR1XS
PANC-03-27 NFzZdHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\Gd2k2UUN3ME23Ok4zPSCwTR?= M37lSXNCVkeHUh?=
S-117 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DUbWlEPTB;N{[uNlchdk1? MUnTRW5ITVJ?
SK-MEL-2 NES0eJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojVTWM2OD15Nj63OUBvVQ>? NFXweG1USU6JRWK=
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CP50-MEL-B M1vldmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljlTWM2OD15Nz60JI5O M2fETHNCVkeHUh?=
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IST-SL1 NV\LclRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvp[IRPUUN3ME2xMlQ1OjRizszN MUDTRW5ITVJ?
COLO-741 NV3HbVR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTFwNEm3O|Eh|ryP M3H3VXNCVkeHUh?=
LU-65 NYnuPWIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTFwNkKyOFkh|ryP NWrmR3NGW0GQR1XS
NCI-H1304 NXWwc3ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXXbZBKSzVyPUGuOlU1QThizszN NXnPWWFwW0GQR1XS
KARPAS-299 NHHZPWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{OxbWlEPTB;MT63PVQ4QSEQvF2= MWHTRW5ITVJ?
NCI-H358 M1XYfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTFwOUW1NFMh|ryP NWnreosxW0GQR1XS
OAW-28 NVu3ToIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnGyTWM2OD1{LkC2PVE6KM7:TR?= NIDuXI5USU6JRWK=
C8166 MnPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJwNkOzPVIh|ryP M33heXNCVkeHUh?=
COLO-678 NICxTWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:3TWM2OD1{LkizO|Y5KM7:TR?= MXnTRW5ITVJ?
SK-N-DZ MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjZSZIzUUN3ME2yMlg3OzhzIN88US=> M{XYb3NCVkeHUh?=
NCI-H82 M4DZZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTJwOUCzOlkh|ryP NF3jendUSU6JRWK=
JVM-2 MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nV[GlEPTB;Mz6wN|E5QCEQvF2= MoizV2FPT0WU
SW1116 MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXm5Wm9XUUN3ME2zMlA2PDFzIN88US=> NVHrNm93W0GQR1XS
MDA-MB-453 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL2ZmI2UUN3ME2zMlExPDN7IN88US=> MmDKV2FPT0WU
Calu-6 NEfYbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVr5XZVXUUN3ME2zMlE6QTdizszN MULTRW5ITVJ?
SHP-77 NIDaXZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PHSWlEPTB;Mz61Nlgh|ryP M2DVUnNCVkeHUh?=
Capan-2 M1TibWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPVZZhvUUN3ME20MlMzPThzIN88US=> M1\RcXNCVkeHUh?=
SW948 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTRwN{S3O|kh|ryP M33SOXNCVkeHUh?=
HDLM-2 M1TENGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DLXWlEPTB;NT6wO|czPSEQvF2= NFzYUoxUSU6JRWK=
LAN-6 Ml\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\tTWM2OD14LkKxOFk2KM7:TR?= NHjze|lUSU6JRWK=
LU-135 NV32WWVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml33TWM2OD14LkSzNFc4KM7:TR?= MXLTRW5ITVJ?
T84 NEHUUo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TBfGlEPTB;Nj65PFY1KM7:TR?= NIXSTWJUSU6JRWK=
CAPAN-1 Ml3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTdwNkKyN|Mh|ryP NGi4V4xUSU6JRWK=
SW1417 NWrlWJltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDvZXVKSzVyPUeuPVE4OzFizszN M2DvSHNCVkeHUh?=
BALL-1 M4DRWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfRWndKSzVyPUiuOVA1ODlizszN NFPqb3FUSU6JRWK=
HT-29 NI\O[3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfmTWM2OD17LkC3OVk6KM7:TR?= NEfGeWlUSU6JRWK=
C3A MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTlwOEizPVQh|ryP MVnTRW5ITVJ?
NCI-H1993 M1;RW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTFyLkWwPFEh|ryP MoXUV2FPT0WU
SK-MEL-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rlXGlEPTB;MUGuOlI5QSEQvF2= MnPHV2FPT0WU
DU-145 MnXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjFTWM2OD1zND61NFUzKM7:TR?= MoLhV2FPT0WU
KP-N-YN MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTqTWM2OD1zND61NVA{KM7:TR?= MYfTRW5ITVJ?
CCRF-CEM MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjHRZdkUUN3ME2xOE44QDB7IN88US=> NEe2Tm5USU6JRWK=
ZR-75-30 NXz3WFYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fpTGlEPTB;MU[uN|MxOyEQvF2= M3LwNHNCVkeHUh?=
A673 M2nu[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTJyLkW1NFch|ryP MXzTRW5ITVJ?
K-562 Mk\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTJ6LkSxPFMh|ryP NHW5[mNUSU6JRWK=

... Click to View More Cell Line Experimental Data
体内研究 BEZ235诱导肿瘤(69%)消退，而对体重增加没有统计学上显著的作用。总之，这些初步的体内功效研究结果表明，BEZ235单一口服给药时能够阻断疾病的发展，与其他抗癌药结合使用时能够增强疗效。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验：

[2]
+ 展开

体外蛋白激酶,PI3K,和mTOR实验:

PI3Kα, β, δ蛋白都由与p110全长蛋白相接的p85 N端的iSH2域组成，只是PI3Kα没有最后的20个氨基酸。PI3Kγ由p110全长蛋白去掉前144个氨基酸产生而来。所有PI3K蛋白在羧基末端加组氨酸标签便于纯化，然后克隆到pBlue-Bac4.5 (用于α, β,和δ亚型) 或者pVL1393 (用于γ 亚型) 质粒中。转染BaculoGold WT基因组DNA的不同的载体按说明书推荐的方法生产各自重组体杆状病毒及重组蛋白。使用激酶发光检测试剂盒测定BEZ235 (NVP-BEZ235)作用于PI3K的活力。在384孔板上进行激酶实验。在每个孔中加入50 nl的测试项目（溶在90%DMSO中）和5ul的反应buffer,反应buffer包含10 μg/ml PI基质 (l-α-磷脂酰肌醇; 由Avanti Polar Lipids提供;预备在3%辛基葡萄糖苷中)，然后加入PI3K 蛋白(p110α, p110β, p110δ,和p110γ分别为10, 25, 10,和150 nM)。加入预备在反应buffer中的5 ul 1 µM 的ATP反应开始，反应进行60分钟 (测p110α, p110β, p110δ)或者120分钟(测p110γ)，随后加入10ul的荧光激酶buffer终止反应。数据用Synergy 2 阅读器阅读用于荧光测试。
细胞实验：

[1]
+ 展开
  • Cell lines: HCT116, DLD-1, SW480
  • Concentrations: 0-1 μM
  • Incubation Time: 48小时
  • Method:

    HCT116 (PIK3CA突变型; 激酶域在H1047R), DLD-1 (PIK3CA突变型；螺旋域在E545K), SW480 (PIK3CA 野生型)人类CRC细胞系，同基因型的DLD-1 PIK3CA突变和野生型细胞培养在含10%FBS和1×青霉素/链霉素的培养基中。细胞按不同的初始密度加入（HCT116: 3000个细胞/每孔, DLD-1: 5500个细胞/每孔, SW480: 4500个细胞/每孔, DLD-1 PIK3CA突变型: 7000个细胞/每孔, DLD-1 PIK3CA野生型: 9000个细胞/每孔)，用来计算不同的生长动力学。16个小时后，细胞加入浓度越来越高的BEZ235中进行温育，含有药物的培养基24小时更换一次。根据产品说明书，加入细胞16小时和药物处理48小时，使用单溶液细胞增殖检测试剂盒以比色法检测细胞活力。与没有用药物处理正在生长的细胞相比，药物处理的细胞的活力也逐渐趋于正常化。使用GraphPad Prism 5软件用4个参数的回归曲线计算IC50值。用于western blot 分析，细胞用0 nM 或者最高抑制剂量(500 nM) BEZ235处理 2, 6, 24, 或者48 小时。


    (Only for Reference)
动物实验：

[2]
+ 展开
  • Animal Models: 雌性Harlan无胸腺裸鼠
  • Formulation: NMP/聚乙二醇300(10/90,v/v)
  • Dosages: 45 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)：
NMP+polyethylene glycol 300 (10+90, v+v) 		30 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 469.55
化学式

C30H23N5O
CAS号 915019-65-7
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量：

总分子量：g/mol

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03373903 Active not recruiting Respiratory Tract Infections Restorbio Inc. November 15 2017 Phase 2
NCT03373903 Active not recruiting Respiratory Tract Infections Restorbio Inc. November 15 2017 Phase 2
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1：

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • 回答：

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

Selleck产品目录册

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

相关PI3K产品

  • Taselisib (GDC 0032) New

    Taselisib (GDC 0032)是一种有效，下一代的β亚型PI3K抑制剂，作用于PI3Kα/δ/γ， IC50分别为0.29 nM/0.12 nM/0.97nM，比作用于PI3Kβ选择性高10倍以上。

  • Pilaralisib (XL147) New

    Pilaralisib (XL147)是一种选择性的可逆I型PI3K抑制剂，作用于PI3Kα/δ/γ，在无细胞试验中IC50为 39 nM/36 nM/23 nM，对PI3Kβ作用较低。Phase 1/2。

  • GNE-317 New

    GNE-317 是一种有效的，大脑渗透性 PI3K 抑制剂。

  • LY294002

    LY294002 是首个合成的已知抑制PI3Kα/δ/β的小分子，在无细胞测定中IC50分别为 0.5 μM/0.57 μM/0.97 μM；在溶液中比在Wortmannin中稳定，也能够阻断自噬体的形成。它不仅能够结合class I PI3Ks和其他PI3K相关的激酶，还能够结合一些与PI3K家族无关的新型靶点。

    Features:LY294002是选择性的, 可渗透细胞的特定PI3K抑制剂，可作用于酶的ATP结合位点，且抑制自体吞噬的螯合作用。

  • 3-Methyladenine (3-MA)

    3-Methyladenine (3-MA)是一种选择性PI3K抑制剂，作用于Vps34和PI3Kγ，在 HeLa细胞中IC50分别为25 μM和60 μM；永久性抑制I型PI3K，但对III型PI3K的抑制是短暂的，也会阻断自噬体的形成。现配现用（加热助溶）。

  • Idelalisib (CAL-101, GS-1101)

    Idelalisib (CAL-101, GS-1101) 是选择性p110δ抑制剂，在无细胞试验中IC50为 2.5 nM；对 p110δ 表现出的选择性是对 p110α/β/γ 的 40 到 300 倍，对p110δ的选择性是对 C2β，hVPS34，DNA-PK 和 mTOR的400到4000倍。

    Features:Calistoga 暗示 CAL-101治疗血液恶性肿瘤可能有更广泛的应用价值。

  • Wortmannin

    Wortmannin是一种首次命名的PI3K抑制剂，在无细胞试验中IC50为3 nM，对 PI3K 家族的选择性较低。也会抑制自噬体的形成，并有效抑制DNA-PK/ATM，在无细胞试验中IC50为16 nM和150 nM。

  • Buparlisib (BKM120, NVP-BKM120)

    Buparlisib (BKM120, NVP-BKM120) 是一种选择性 PI3K 抑制剂，在无细胞试验中作用于p110α/β/δ/γ的IC50分别为 52 nM/166 nM/116 nM/262 nM。对 VPS34，mTOR，DNAPK 的作用效果下降，而对 PI4Kβ几乎没有活性。Phase 2。

    Features:BKM120是可用于口服的生物有效的PI3K抑制剂。

  • Pictilisib (GDC-0941)

    Pictilisib (GDC-0941) 是一种有效的PI3Kα/δ抑制剂，在无细胞试验中IC50为 3 nM，对p110β (11倍)和p110γ (25倍)具有适度的选择性。Phase 2。

  • Alpelisib (BYL719)

    Alpelisib (BYL719) 是一种有效的选择性PI3Kα抑制剂，在无细胞试验中IC50为 5 nM，对PI3Kβ/γ/δ具有极弱的作用。Phase 2。

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID