Sirtuin
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S1541 | Selisistat (EX 527) | <1 mg/mL | 49 mg/mL | 18 mg/mL |
| S2804 | Sirtinol | <1 mg/mL | 23 mg/mL | <1 mg/mL |
| S1899 | Nicotinamide (Vitamin B3) | 24 mg/mL | 24 mg/mL | 24 mg/mL |
| S7845 | SirReal2 | <1 mg/mL | 84 mg/mL | <1 mg/mL |
| S5914 | AK 7 | <1 mg/mL | 87 mg/mL | 3 mg/mL |
| S8627 | OSS_128167 | <1 mg/mL | 73 mg/mL | <1 mg/mL |
| S4900 | Tenovin-6 | 98 mg/mL | 98 mg/mL | <1 mg/mL |
| S7577 | AGK2 | <1 mg/mL | 10 mg/mL | <1 mg/mL |
| S8245 | Thiomyristoyl | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S8460 | Salermide | <1 mg/mL | 78 mg/mL | 7 mg/mL |
| S8628 | 3-TYP | 5 mg/mL | 29 mg/mL | 29 mg/mL |
| S1129 | SRT1720 HCl | <1 mg/mL | 38 mg/mL | <1 mg/mL |
| S5918 | CAY10602 | <1 mg/mL | 56 mg/mL | <1 mg/mL |
| S4735 | Salvianolic acid B | 100 mg/mL | 100 mg/mL | 100 mg/mL |
| S8270 | SRT2183 | <1 mg/mL | 93 mg/mL | 3 mg/mL |
| S7792 | SRT2104 (GSK2245840) | <1 mg/mL | 16 mg/mL | <1 mg/mL |
| S2391 | Quercetin | <1 mg/mL | 61 mg/mL | 10 mg/mL |
| S2298 | Fisetin | <1 mg/mL | 57 mg/mL | 3 mg/mL |
| S8481 | SRT3025 HCl | <1 mg/mL | 100 mg/mL | 5 mg/mL |
特异性亚型抑制剂
- Sirtuin抑制剂（19）
- 新Sirtuin产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1541 |
Selisistat (EX 527)Selisistat (EX 527)是一种有效的，选择性SIRT1抑制剂，无细胞试验中IC50为38 nM，比作用于SIRT2和SIRT3选择性高200倍以上。Phase 2。 |
The eect of Melatonin, luzindole, and EX527 treatment on apoptotic index, infarct size, lactate dehydrogenase (LDH) release, and CK release in IR-injured hearts. Representative photomicrographs of in situ detection of apoptotic myocytes by TUNEL staining. Green fluorescence shows TUNEL-positive nuclei; blue fluorescence shows nuclei of total cardiomyocytes; original magnification 9x400. Sacle bar: 100 um.
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| S2804 |
SirtinolSirtinol是一种特异性SIRT1和SIRT2抑制剂，无细胞试验中IC50分别为131 μM和38 μM。 |
SIRT1 inhibitor exacerbates TBI-induced mitochondrial damage, promotes neuronal apoptosis and activates p38 MAPK signaling. Rats were injected intraperitoneally with the SIRT1 inhibitor sirtinol (10 mg/kg) 30 min before LFP-induced TBI. After 12 h, rats were sacrificed. (A) The expression of SIRT1 and β-actin were detected by Western blot. β-Actin was used as loading control. (B) Quantification of Western blots for SIRT1. (C) The expression of SIRT1 was analyzed by immunohistochemical staining post-TBI.
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| S1899 |
Nicotinamide (Vitamin B3)Nicotinamide (Vitamin B3) 是一种水溶性维生素，是NAD 和 NADP的活性成分，也是一种sirtuins抑制剂。 |
Immunoprecipitation-western blot for analyzing acetylated Snail in Snail-transfected 293T cells (upper) and FaDu-Snail cells (lower) treated with a vehicle control (Ctrl), a HDAC inhibitor TSA 5 nM for 8 hr, a SIRT1 inhibitor NAM(Nicotinamide) 10 mM for 8 hr, or in combination. |
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| S7845 |
SirReal2SirReal2是一种有效的选择性Sirt2抑制剂，IC50为140 nM。 |
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| S5914New |
AK 7AK 7是具有血脑屏障渗透性的SIRT2抑制剂，IC50为15.5 μM。 |
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| S8627New |
OSS_128167OSS-128167是一种特异性的SIRT6抑制剂，对SIRT6, SIRT1和SIRT2的IC50分别为89, 1578和751 μM。 |
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| S4900 |
Tenovin-6Tenovin-6是p53转录活性的小分子激活剂。 |
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| S7577 |
AGK2AGK2是一个有效的选择性SIRT2抑制剂，IC50值为3.5 μM。对其他如SIRT1或SIRT3的抑制作用，在10倍以上的浓度时仍很微弱。 |
The effect of AGK-2 on AKT activation in HeLa cells in response to insulin.
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| S8245 |
ThiomyristoylThiomyristoyl是一种有效的、特异性SIRT2抑制剂，IC50为28 nM。它抑制SIRT1的IC50值为98 μM，而在浓度高达200 μM时，对SIRT3没有抑制作用。 |
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| S8460 |
SalermideSalermide是一种反向酰胺，在体外对Sirt1和Sirt2具有强的抑制作用。相对于Sirt1，Salermide对Sirt2的抑制更为有效。 |
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| S8628 |
3-TYP3-TYP是SIRT3的选择性抑制剂，相对于Sirt1和Sirt2来说，对Sirt3具有较高选择性。对SIRT1、SIRT2、SIRT3的IC50分别为88 nM、92 nM、16 nM。 |
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| S1129 |
SRT1720 HClSRT1720 HCl是一种选择性的SIRT1激活剂，无细胞试验中EC50为0.16 μM，对SIRT2和SIRT3的作用弱230倍以上。 |
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| S5918New |
CAY10602CAY10602是有效的SIRT1激活剂。 |
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| S4735 |
Salvianolic acid BSalvianolic acid B (Sal B)是一种抗氧化剂和自由基清除化合物，是从丹参中提取出来的最丰富的生物活性化合物。 |
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| S8270 |
SRT2183SRT2183是sirtuin蛋白亚型SIRT1的小分子激活剂。 |
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| S7792 |
SRT2104 (GSK2245840)SRT2104 (GSK2245840)是一种选择性 SIRT1 活化剂，参与能量平衡的调节。Phase 2。 |
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| S2391 |
QuercetinQuercetin是蔬菜水果和白酒中的天然黄酮类化合物，是一种体外重组Sirt1蛋白的激活剂同时也是PI3K抑制剂，IC50为2.4 – 5.4 μM。 |
After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF. |
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| S2298 |
FisetinFisetin 是有效的Sirtuin活化化合物(STAC)，可以调节Sirtuin。 |
Liver pathology and serum markers of liver injury in mice fed control (Ctrl), or ethanol (EtOH), or ethanol combined with fisetin (E/Fisetin) diet for 4 weeks. (A) Light microscopy with hematoxylin and eosin staining shows lipid accumulation (arrows) in the liver of mice after alcohol exposure, which was alleviated by fisetin administration. (B) Plasma alanine aminotransferase (ALT) and (C) aspartate aminotransferase (AST) activities. Infinity ALT and AST reagents were used formeasuring ALT and AST activities. Scale bar: 50 lm. Results are mean±SD (n = 3 to 6). Results for bars that do not share
a letter differed significantly among groups (p < 0.05). Significant differences among groups are determined by analysis of variance followed by Tukey’s test.
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| S8481 |
SRT3025 HClSRT3025是一种具有口服活性的SIRT1小分子激活剂。 |
