SIRT1 选择性抑制剂 | 激活剂 | 调节剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S8270 SRT2183

SRT2183是sirtuin蛋白亚型SIRT1的小分子激活剂。

Selective
S5918 CAY10602

CAY10602 is a potent SIRT1 activator.

Selective
S8481 SRT3025 HCl

SRT3025是一种具有口服活性的SIRT1小分子激活剂。

Selective
S1541 Selisistat (EX 527)

Selisistat (EX 527)是一种有效的,选择性SIRT1抑制剂,无细胞试验中IC50为38 nM,比作用于SIRT2和SIRT3选择性高200倍以上。Phase 2。

Selective SIRT1, IC50: 38 nM
S1129 SRT1720 HCl

SRT1720 HCl是一种选择性的SIRT1激活剂,无细胞试验中EC50为0.16 μM,对SIRT2和SIRT3的作用弱230倍以上。

Selective SIRT1, EC50: 0.16 μM
S6880 SRT-1460

SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.

Selective SIRT1, EC1.5: 2.9 μM
S3262 Scopolin

Scopolin, a coumarin isolated from Arabidopsis thaliana (Arabidopsis), attenuates hepatic steatosis through activation of SIRT1-mediated signaling cascades, a potent regulator of lipid homeostasis.

Selective
S3168 cis-Resveratrol

cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA po

Selective
S6744 Inauhzin

Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.

Selective
S2347 Quercetin Dihydrate

Quercetin Dihydrate是一种广泛分布于植物的黄酮类,是一种抗氧化剂,与许多其他酚类杂环化合物类似。

Selective
S7792 SRT2104 (GSK2245840)

SRT2104 (GSK2245840)是一种选择性 SIRT1 活化剂,参与能量平衡的调节。Phase 2。

Selective
S8460 Salermide

Salermide是一种反向酰胺,在体外对Sirt1Sirt2具有强的抑制作用。相对于Sirt1,Salermide对Sirt2的抑制更为有效。

Pan
S8628 3-TYP

3-TYP是SIRT3的选择性抑制剂,相对于Sirt1和Sirt2来说,对Sirt3具有较高选择性。对SIRT1、SIRT2、SIRT3的IC50分别为88 nM、92 nM、16 nM。

Pan SIRT1, IC50: 88 nM
S4900 Tenovin-6

Tenovin-6是p53转录活性的小分子激活剂。

Pan SIRT1, IC50: 21 μM
S2804 Sirtinol

Sirtinol是一种特异性SIRT1SIRT2抑制剂,无细胞试验中IC50分别为131 μM和38 μM。

Pan SIRT1, IC50: 131 μM
S8627 OSS_128167

OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.

Pan SIRT1, IC50: 1578 μM
S1396 Resveratrol (SRT501)

Resveratrol具有广泛靶点,包括环氧酶(如COX, IC50=1.1 μM)、脂肪氧合酶(LOC, IC50=2.7 μM)、sirtuins和其他蛋白质。它是一种天然的植物抗毒素,具有抗癌,抗炎,降血糖和其他有益心血管的作用。

Pan