Resveratrol (SRT501)

For research use only. Not for use in humans.

目录号:S1396 别名: trans-Resveratrol 中文名称:白藜芦醇

Resveratrol (SRT501) Chemical Structure

CAS No. 501-36-0

Resveratrol (SRT501, trans-Resveratrol)具有广泛靶点,包括环氧酶(如COX, IC50=1.1 μM)、脂肪氧合酶(LOC, IC50=2.7 μM)、sirtuins和其他蛋白质。它是一种天然的植物抗毒素,具有抗癌,抗炎,降血糖和其他有益心血管的作用。Resveratrol可诱导线粒体自噬、细胞自噬和自噬依赖性的凋亡。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 1068.72 现货
RMB 804.89 现货
RMB 1382.15 现货
RMB 2551.88 现货
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客户使用Selleck生产的Resveratrol (SRT501)发表文献41篇:

产品安全说明书

Autophagy抑制剂选择性比较

生物活性

产品描述 Resveratrol (SRT501, trans-Resveratrol)具有广泛靶点,包括环氧酶(如COX, IC50=1.1 μM)、脂肪氧合酶(LOC, IC50=2.7 μM)、sirtuins和其他蛋白质。它是一种天然的植物抗毒素,具有抗癌,抗炎,降血糖和其他有益心血管的作用。Resveratrol可诱导线粒体自噬、细胞自噬和自噬依赖性的凋亡。
靶点
SIRT1 [2]
(Cell-free assay)
SIRT2 [2]
(Cell-free assay)
Quinone reductase 2 [9]
(Cell-free assay)
IKK β [1]
(Cell-free assay)
COX1 [9]
(Cell-free assay)
88 nM 1 μM 1.1 μM
体外研究

Resveratro 抑制环氧合酶和脂氧化酶,PKCs和p56lck, ERK1,JNK1,p38,IKK β,Src,STAT3,核苷酸还原酶,DNA聚合酶α和 δ,PKD,PKC α,醌还原酶2,以及芳香化酶的活性,IC50值为0.035-60 μM。Resveratrol也是腺苷酸环化酶和AMPK的活化剂,IC50值分别为0.8 μM和50 μM。Resveratrol作为抑制剂或活化剂,能够减少细胞炎症相关的表现,抑制癌症细胞的生长并诱导细胞凋亡,逆转内皮素-1受激的细胞应答,抑制佛波醇酯诱导的COX-2表达,抑制细胞中DNA合成,抵抗甲萘醌诱导的细胞死亡,并且改善细胞线粒体功能和葡萄糖/脂质代谢。[1]Resveratrol也是抗衰老酶的活化剂。Resveratrol降低作用于乙酰化底物和NAD+的SIRT1的Michaelis常数,通过促进SIRT1依赖性的p53脱乙酰作用增加细胞存活。在酵母中,Resveratrol通过刺激Sir2模拟热量限制,增加DNA稳定性并延长寿命。[2] Resveratrol通过其抗氧化活性,能够有效保护离体的大鼠心脏免受心脏缺血/再灌注损伤,改善发展压和主动脉血流的恢复,降低丙二醛的浓度并减少梗死面积。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HL60 cell line NXTy[lRRWHKxbHnm[ZJifGmxbjDhd5NigQ>? MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdCCuaX7lMEBKSzVyPUWg{txO NGO5NJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNk[4OlU1Oyd-MU[2PFY2PDN:L3G+
human K562 cell line NVfLTYFUWHKxbHnm[ZJifGmxbjDhd5NigQ>? Mlf0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGxibHnu[UBmgHC{ZYPzbY5oKEKlcj3BZowtKEmFNUC9Nlgh|ryP Ml\PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ4OE[1OFMoRjF4Nki2OVQ{RC:jPh?=
HUVEC MlHXSpVv[3Srb36gZZN{[Xl? MV6xNFAh|ryP MWSxJIRigQ>? M1PrZ2lv\HWldHnvckBw\iCvaYTvZ4hwdmS{aXHsJIJqd2enbnXzbZMhcW5iSELPNk1qdmS3Y3XkJGhWXkWFIHH0JFExOCC3bX;sM2wheHKndILlZZRm\CCob4KgNUBl[XliZn;scI94\WRiYomgZ49ueG:3bnSge4F{cG:3dDDhcoQhUDKRMj30doVifG2nboSgcYVie3W{ZXSgZYZ1\XJiMUCg[IF6eyCkeTDNbZRwXHKjY3vldkBT\WRic4ThbY5qdmdvYnHz[YQh[XO|YYm= NIjsUoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i1PVI1QSd-MkO4OVkzPDl:L3G+
Hepa1clc7 NYCzXZVVS3m2b4TvfIlkcXS7IHHzd4F6 MnPmO|IhcHK| NWXMNGJ6S3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhUGWyYUHjcIM4KGOnbHzzJIFnfGW{IEeyJIhzeyxiSVO1NF0yOc7:TT6= NGXXdVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEC3OVc1Oid-MUCwO|U4PDJ:L3G+
MCF7 NXG3U|BMTnWwY4Tpc44h[XO|YYm= NHTiOoQ3KGi{cx?= NEDuOHlKdmirYnn0bY9vKG:oIIDoc5Jjd2xiZYP0[ZIucW6mdXPl[EBwem6rdHjpcoUh\GWlYYLic5h6dGG|ZTDpckBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IE[gbJJ{NCCLQ{WwQVE6|ryPLh?= M4fpV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyMEe1O|QzLz5zMEC3OVc1OjxxYU6=
U937 M4LQN2Z2dmO2aX;uJIF{e2G7 NVTaZnh3UW6qaXLpeIlwdiCxZjDbNVREZWSnaInkdo9ie2OxcnLpZ{Bi[2mmIIXweIFs\SCrbjDoeY1idiCXOUO3JINmdGy|IHL5JG1q[2ijZXzpd{1O\W62ZX6gdIxwfCxiS3m9N|XPxE1w MlftQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF{N{e3OlQoRjFzMke3O|Y1RC:jPh?=
U937 MXLGeY5kfGmxbjDhd5NigQ>? MVHJcohq[mm2aX;uJI9nKDJvW{GsNk0{UCiQKW3k[Y95gS2GLXfseYNwe2VidYD0ZYtmKGmwIHj1cYFvKFV7M{egZ4VtdHNiYomgd4NqdnSrbHzheIlwdiC|cHXjeJJwdWW2comgbY4heHKnc3XuZ4Uhd2Zic3;kbZVuNW[{ZXWgZpVn\mW{ NYHyZ4lbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGyO|c4PjRpPkGxNlc4PzZ2PD;hQi=>
HL60 M{XmbmZ2dmO2aX;uJIF{e2G7 NF3SZ|FKdmirYnn0bY9vKG:oIEKtX|EtOi1|SDjOLX1l\W:6eT3EMYdtfWOxc3WgeZB1[WunIHnuJIh2dWGwIFjMOlAh[2WubIOgZpkhe2OrboTpcIxifGmxbjDzdIVkfHKxbXX0dpkhcW5icILld4Vv[2Vib3[gd49lcXWvLX\y[YUh[nWoZnXy NVXNeY5CRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGyO|c4PjRpPkGxNlc4PzZ2PD;hQi=>
U937 NFHmTVNHfW6ldHnvckBie3OjeR?= NUT3XpNYUW6qaXLpeIlwdiCxZjDbNVREZWSnaInkdo9ie2OxcnLpZ{Bi[2mmIIXweIFs\SCrbjDoeY1idiCXOUO3JINmdGy|IHL5JJNkcW62aXzsZZRqd25ic4DlZ5Rzd22ndIL5JIlvKHC{ZYPlcoNmKG:oIIPv[Il2dS2ocnXlJIJ2\m[nch?= NIr0OZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUK3O|c3PCd-MUGyO|c4PjR:L3G+
HL60 M1:3NmZ2dmO2aX;uJIF{e2G7 MUDJcohq[mm2aX;uJI9nKFtzNFPd[IVpgWS{b3HzZ49z[mmlIHHjbYQhfXC2YXvlJIlvKGi3bXHuJGhNPjBiY3XscJMh[nlic3PpcpRqdGyjdHnvckB{eGWldILvcYV1enliaX6gdJJme2WwY3Wgc4Yhe2:maYXtMYZz\WViYoXm[oVz NHX5eZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUK3O|c3PCd-MUGyO|c4PjR:L3G+
CHO MofPSpVv[3Srb36gZZN{[Xl? NX:wOWhKSmyxY3vh[IUhd2ZicnH0JGdtfXRzIHX4dJJme3OnZDDpckBEUE9iY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kAzNVtzLEKtN2gpVimfZHXvfJkuTC2pbIXjc5NmKHWydHHr[UBjgSC|Y3nueIltdGG2aX;uJJNx\WO2cn;t[ZRzgQ>? NETLWIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUK3O|c3PCd-MUGyO|c4PjR:L3G+
CHO NVHI[pBWTnWwY4Tpc44h[XO|YYm= MVjCcI9kc2GmZTDv[kBz[XRiR3z1eFEh\XiycnXzd4VlKGmwIFPIU{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGuxOGNe\GWqeXTyc4F{[2:{YnnjJIFkcWRidYD0ZYtmKGK7IIPjbY51cWyuYYTpc44he3CnY4Tyc41mfHK7 MmDZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF{N{e3OlQoRjFzMke3O|Y1RC:jPh?=
CHO MkjFSpVv[3Srb36gZZN{[Xl? MUXCcI9kc2GmZTDv[kBpfW2jbjDHcJV1OyCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gNk1cOSx{LUPILG4qZWSnb4j5MWQu\2y3Y3;z[UB2eHSja3WgZpkhe2OrboTpcIxifGmxbjDzdIVkfHKxbXX0dpk> Mm\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF{N{e3OlQoRjFzMke3O|Y1RC:jPh?=
CHO NH\pVpNHfW6ldHnvckBie3OjeR?= NWjtOZN4SmyxY3vh[IUhd2ZiaIXtZY4hT2y3dEOg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFtzNFPd[IVpgWS{b3HzZ49z[mmlIHHjbYQhfXC2YXvlJIJ6KHOlaX70bYxt[XSrb36gd5Bm[3S{b33leJJ6 MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTJ5N{e2OEc,OTF{N{e3OlQ9N2F-
HL60 MXLGeY5kfGmxbjDhd5NigQ>? MnfwTY4hfmm2cn:gbY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RicILvcIln\XKjdHnvckBw\iCKTE[wJINmdGy|LDDJR|UxRTYQvF2u M3TYVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OEe3OVk{Lz5zMki3O|U6OzxxYU6=
RAW264.7 M{fOUWZ2dmO2aX;uJIF{e2G7 NFvpUVhKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5Qhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36gbY4hdGmyb4DvcJl{[WOlaHHybYRmNWGldHn2ZZRm\CCvb4Xz[UBu[WO{b4DoZYdmKFKDV{K2OE44KGOnbHzzMEBKSzVyPUG1MlnPxE1w NI\MT3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEW1Nlc2QSd-MUS1OVI4PTl:L3G+
RAW264.7 NIC3SXNHfW6ldHnvckBie3OjeR?= MmHUTY5pcWKrdH;yfUBm\m[nY4Sgc44hWEeHLUKgdJJw\HWldHnvckBqdiCOUGOtd5RqdXWuYYTl[EBTSVd{NkSuO{Bk\WyuczygTWM2OD12zszNMi=> NEX2N2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC4NFk5QCd-MUWwPFA6QDh:L3G+
RAW264.7 Mn70SpVv[3Srb36gZZN{[Xl? MmqybY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiUFfFMVIheHKxZIXjeIlwdiCrbjDMVHMue3SrbYXsZZRm\CCUQWeyOlQvPyClZXzsd{whUUN3ME2yNE45|ryPLh?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyMUC2OEc,OTV3MEGwOlQ9N2F-
T47D MYTGeY5kfGmxbjDhd5NigQ>? M4D0NmV{fHKxZ3XubYMh[WO2aY\peJkhcW5iaIXtZY4hXDR5RDDj[YxteyCjc4Pld5Nm\CCjczDkdpVoKGyndnXsJINifXOrbnegd5RqdXWuYYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:wIHXxeYl3[WynboSgeI8hOTBicF2g[ZN1emGmaX;sJIJ6KGGuYX3hdkBjdHWnIHHzd4F6NCCDY4Tpeol1gT1yLkCz{txONg>? Ml7QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5OEe0N|YoRjF3N{i3OFM3RC:jPh?=
MCF7 MoXLSpVv[3Srb36gZZN{[Xl? MkX6SZN1em:pZX7pZ{Bi[3Srdnn0fUBqdiCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHTyeYchdGW4ZXygZ4F2e2mwZzDzeIlufWyjdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25iZYH1bZZidGWwdDD0c{AyOCCyTTDld5Rz[WSrb3ygZpkh[WyjbXHyJIJtfWViYYPzZZktKEGldHn2bZR6RTFwNt88UU4> Mn;rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5OEe0N|YoRjF3N{i3OFM3RC:jPh?=
MDA-MB-231 M4n6dWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MojkTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIILldZVqemWmIH\vdkBidnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNuIFnDOVA:OjBwNd88UU4> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjJ3ME[zOkc,OTZ{NUC2N|Y9N2F-
U937 M2j2PGN6fG:2b4jpZ4l1gSCjc4PhfS=> M{PabGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU6OzdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHdUXDFidHXzeEwhUUN3ME2xO:69VS5? NXHpc4Z7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[yOVI6OjRpPkG2NlUzQTJ2PD;hQi=>
HL60 MnzGRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNuIFnDOVA:Pc7:TT6= MkO5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3OECyNFQoRjF4NUiwNlA1RC:jPh?=
HEK293T MnzwSpVv[3Srb36gZZN{[Xl? MkXNTY5pcWKrdHnvckBw\iCWTl[tZYxxcGFvaX7keYNm\CCQRj3rZZBx[UJiYXP0bZZifGmxbjDpckBJTUt{OUPUJINmdGy|LDDJR|UxRTJyzszNMi=> NH7oRXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GyOVI4OCd-MUexNlUzPzB:L3G+
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RAW 264.7 NUDXNHZMTnWwY4Tpc44h[XO|YYm= NWfzS4g6UW6qaXLpeIlwdiCxZjDMVHMh[W6mIGTOSk1idHCqYT3hZ5RqfmG2ZXSgUm8heHKxZIXjeIlwdiCrbjDteZJqdmViUlHXJFI3PC55IHPlcIx{NCCLQ{WwQVI{NjYQvF2u M4rVPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkWzPFQ1Lz5zN{K1N|g1PDxxYU6=
Hepa 1c1c7c1 NHjOO4tHfW6ldHnvckBie3OjeR?= NEXSZVcyOi53IIXN M3zRdFI1KGi{cx?= Mnr0TY5lfWO2aX;uJI9nKHG3aX7vcoUhemWmdXP0ZZNmKGmwIH3veZNmKG23dHHueEBJ\XCjIEHjNYM4[zFiY3XscJMh[XRiMUKuOUB2VSCjZoTldkAzPCCqcoOgdoVt[XSrdnWgeI8h[2:wdILvcEwhSWO2aY\peJk:OS5zNt88UU4> MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzNzNkmxPEc,OTd|MU[5NVg9N2F-
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primary osteoblast cells NVO1ephDTnWwY4Tpc44h[XO|YYm= MUGxJJVO NHyxRYQ4OiCqcoO= MUDJcoNz\WG|ZTDpckBwe3Snb3PhcINqdiCuZY\lcJMhcW5icnH0JJBzcW2jcomgc5N1\W:kbHHzeEBk\WyuczDheEAyKHWPIHHmeIVzKDd{IHjyd{BjgSCHTFnTRS=> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzVzM{i2O{c,OTd3MUO4Olc9N2F-
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primary osteoblast cells M2W1bGZ2dmO2aX;uJIF{e2G7 M3rEPVEhfU1? Mn3aO|IhcHK| MoTqTY5kemWjc3WgbY4hd3O2ZX;wc451cW5ibWLORUBt\X[nbIOgbY4hemG2IIDybY1ienlib4P0[Y9jdGG|dDDj[YxteyCjdDCxJJVOKGGodHXyJFczKGi{czDifUBTXC2SQ2K= NXnpbHZNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1NVM5PjdpPkG3OVE{QDZ5PD;hQi=>
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Nanog / Oct-4 / Sox-2 ; 

PubMed: 21304978     


Pancreatic CSCs were treated with resveratrol (0–30 µM) for 48 h. The expression of Nanog, Oct-4 and Sox-2 was measured by the Western blot analysis. GAPDH was used as a loading control. 

p-EGFR / EGFR / p-HER2 / HER2 / p-ERK / ERK / PTEN ; 

PubMed: 20729295     


DU145 cells were treated with DMSO, and 10, 20 or 50 µm resveratrol. Western blots show resveratrol decreased phosphorylation of EGFR-Tyr1068 (upper panel), HER2-Tyr1221/1222 (second panel).

21304978 20729295
Growth inhibition assay
Cell viability; 

PubMed: 23272133     


A, MTS assay was performed on PC-3M-MM2 cells treated with vehicle or different concentrations of resveratrol (5–100 µM) for 72 h which showed that resveratrol dose-dependently reduced cell viability. B, Decrease in cell viability by resveratrol was time-dependent in the resveratrol-treated groups (25 and 50 µM) compared to vehicle.

23272133
体内研究 Resveratrol改善高热量饮食小鼠的健康和生存。Resveratrol (22.4 毫克/千克/天)使高热量饮食中年小鼠的生理机能转变为与标准饮食小鼠相符,并且显著增加他们的存活率。Resveratrol产生与延长寿命相关的改变,包括增加胰岛素敏感性,降低胰岛素样生长因子-1(IGF-I)的水平,增加AMP活化的蛋白激酶(AMPK) 过氧化物酶体增殖物激活的受体-γ共激活因子1α(PGC-1α)的活性,增加线粒体数量,并改善运动机能。在153显著改变的通路中,Resveratrol能够抵抗144的高热量饮食作用。[3] 在各种啮齿动物癌症模型中,Resveratrol被证明能够抑制肿瘤的发生和生长。Resveratrol在低至200微克/千克剂量下已经在结肠癌变的大鼠模型中表现出了功效。在40毫克/千克的较高剂量下,Resveratrol使患有皮下成神经细胞瘤的小鼠的存活率从0%增加到70%。Resveratrol在48微克/千克剂量下每天给药,抑制小鼠角膜微囊袋法中血管形成。[3] Resveratrol对心脏疾病表现出有益作用。Resveratrol阻断高脂饮食诱发的血小板聚集的增加。Resveratrol增加内皮细胞和诱导型一氧化氮合酶的表达。在易卒型自发性高血压大鼠体内,Resveratrol显著降低氧化应激的标志物,如血清中的糖化白蛋白和尿液中的8-羟基鸟嘌呤核苷。Resveratrol加入到饮用水中15天(1 毫克/千克)足以改善离体心脏的功能和冠状动脉血流量的恢复。[3] Resveratrol在体内显示抗炎活性。Resveratrol显著降低急慢性化学诱发的水肿,脂多糖诱发的气道炎症和骨关节炎,并且有助于防止同种异体移植排斥。在大鼠体内,Resveratrol静脉注射给药降低局部缺血/再灌注诱发的炎症,减少次黄嘌呤/黄嘌呤氧化酶(HX/ XO)或血小板活化因子产生的氧化剂,但不影响白三烯B4。[3] Resveratrol显示出对中风和脑损伤的有益作用。Resveratrol在100纳克/千克和1 微克/千克的极低剂量下静脉注射给药,显著减少大鼠大脑中动脉闭塞后缺血体积和脑组织含水量。[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[6]

- 合并
  • Cell lines: 人类乳腺癌细胞MCF-7
  • Concentrations: 30-300 μM
  • Incubation Time: 2天
  • Method:

    细胞接种于平底96孔微量滴定板(4000细胞/ 6.4毫米直径的孔)。在12-24小时后,细胞用DMSO(0.1–0.3%)处理或者增加Resveratrol的剂量。治疗48小时后,细胞用10μL 的MTT试剂在37℃下处理4小时,然后用100 μL增溶溶液在37 ℃下处理过夜。甲臜产生的数量利用分光光度微量滴定板读数器在570nm波长下测量。


    (Only for Reference)
动物实验:

[7]

- 合并
  • Animal Models: 人类卵巢异种移植物PA-1
  • Dosages: 100毫克/千克
  • Administration: 每天腹腔注射连续四周
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 45 mg/mL warmed (197.16 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
5% DMSO+30% PEG 300+ddH2O
15mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 228.24
化学式

C14H12O3

CAS号 501-36-0
储存条件 粉状
溶于溶剂
别名 trans-Resveratrol

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03743636 Recruiting Drug: Nicotinamide riboside|Drug: Resveratrol|Other: Placebo Peripheral Artery Disease Northwestern University|American Heart Association October 1 2018 Phase 3
NCT03253913 Unknown status Drug: Sirolimus|Drug: Resveratrol Lymphangioleiomyomatosis University of Cincinnati|National Heart Lung and Blood Institute (NHLBI) March 31 2018 Phase 2
NCT01476592 Completed Dietary Supplement: Resveratrol Neuroendocrine Tumor University of Wisconsin Madison December 2011 Not Applicable

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

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Autophagy Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID