NADPH-oxidase

抑制剂选择性比较

NADPH-oxidase产品

所有产品 NADPH-oxidase抑制剂(5) 新NADPH-oxidase产品

产品目录	产品描述	文献引用	实验数据
S8639	Diphenyleneiodonium chloride (DPI) Diphenyleneiodonium chloride (DPI)是NADPH oxidase的抑制剂，也是有效的、不可逆的iNOS/eNOS抑制剂。	Biochem Biophys Res Commun, 2019, 511(4):847-854 Nat Commun, 2018, 9(1):4429
S6656^New	VAS2870 VAS2870是一种泛NADPH oxidase(NOX)抑制剂。
S2425	Apocynin Apocynin是一种选择性NADPH氧化酶抑制剂，IC50 为10 μM.	J Exp Clin Cancer Res, 2019, 38(1):225 Oxid Med Cell Longev, 2019, 2019:4578175 Oxid Med Cell Longev, 2019, 2019:1209307	NOX inhibition attenuated thyroid morphologic changes of rats. (a) A representative figure from control group; (b) a representative figure from PCB group; (c) a representative figure from PCB + APO group; (d) a representative figure from APO group; (e) histological scores of thyroid tissue. ∗P < 0.05 versus control group. #P < 0.05 versus PCB group (original magnification ×200).
S7171	Setanaxib (GKT137831) GKT137831是一种有效的双NADPH oxidase NOX1/NOX4抑制剂，Ki分别为110 nM和140 nM。对NOX1、4、5的选择性约为对NOX2的10倍，不抑制XO或ROS/RNS。	J Clin Invest, 2019, 129(6):2431-2445 Int J Cancer, 2019, 10.1002/ijc.32496 Redox Biol, 2019, 22:101116	(C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group).
S5304	2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171)是一种有效的、选择性的NADPH-oxidase抑制剂，对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。

产品目录	产品描述	文献引用	实验数据
S8639	Diphenyleneiodonium chloride (DPI) Diphenyleneiodonium chloride (DPI)是NADPH oxidase的抑制剂，也是有效的、不可逆的iNOS/eNOS抑制剂。	Biochem Biophys Res Commun,2019, 511(4):847-854 Nat Commun,2018, 9(1):4429
S6656^New	VAS2870 VAS2870是一种泛NADPH oxidase(NOX)抑制剂。
S2425	Apocynin Apocynin是一种选择性NADPH氧化酶抑制剂，IC50 为10 μM.	J Exp Clin Cancer Res,2019, 38(1):225 Oxid Med Cell Longev,2019, 2019:4578175 Oxid Med Cell Longev,2019, 2019:1209307	NOX inhibition attenuated thyroid morphologic changes of rats. (a) A representative figure from control group; (b) a representative figure from PCB group; (c) a representative figure from PCB + APO group; (d) a representative figure from APO group; (e) histological scores of thyroid tissue. ∗P < 0.05 versus control group. #P < 0.05 versus PCB group (original magnification ×200).
S7171	Setanaxib (GKT137831) GKT137831是一种有效的双NADPH oxidase NOX1/NOX4抑制剂，Ki分别为110 nM和140 nM。对NOX1、4、5的选择性约为对NOX2的10倍，不抑制XO或ROS/RNS。	J Clin Invest,2019, 129(6):2431-2445 Int J Cancer,2019, 10.1002/ijc.32496 Redox Biol,2019, 22:101116	(C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group).
S5304	2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171)是一种有效的、选择性的NADPH-oxidase抑制剂，对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。