NADPH-oxidase
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S8639 | Diphenyleneiodonium chloride (DPI) | <1 mg/mL | 13 mg/mL | <1 mg/mL |
| S2425 | Apocynin | <1 mg/mL | 33 mg/mL | 33 mg/mL |
| S7171 | GKT137831 | <1 mg/mL | 78 mg/mL | <1 mg/mL |
| S5304 | 2-Acetylphenothiazine (ML171) | -1 mg/mL | 48 mg/mL | -1 mg/mL |
- NADPH-oxidase抑制剂（4）
- 新NADPH-oxidase产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S8639New |
Diphenyleneiodonium chloride (DPI)Diphenyleneiodonium chloride (DPI)是NADPH oxidase的抑制剂，也是有效的、不可逆的iNOS/eNOS抑制剂。 |
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| S2425 |
ApocyninApocynin是一种选择性NADPH氧化酶抑制剂，IC50 为10 μM. |
NOX inhibition attenuated thyroid morphologic changes of rats. (a) A representative figure from control group; (b) a representative figure from PCB group; (c) a representative figure from PCB + APO group; (d) a representative figure from APO group; (e) histological scores of thyroid tissue. ∗P < 0.05 versus control group. #P < 0.05 versus PCB group (original magnification ×200). |
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| S7171 |
GKT137831GKT137831是一种有效的双NADPH oxidase NOX1/NOX4抑制剂，Ki分别为110 nM和140 nM。对NOX1、4、5的选择性约为对NOX2的10倍，不抑制XO或ROS/RNS。 |
Serum markers of liver injury and liver pathology in mice fed control (Ctrl) or ethanol (EtOH) for four weeks with or without GKT137831 for the last two weeks. (A) Light microscopy with hematoxylin & eosin staining shows accumulation of lipid droplets (arrows) and necrosis (arrowheads) in the liver of ethanol-fed mice, which was attenuated by GKT137831 treatment. (B) Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Serum ALT and AST activities were measured by using Infinity ALT and AST Reagents. Scale bar: 20μM. Results are mean ± SD (n=6). Results for bars that do not share a letter differed significantly among groups (P <0.05). Significant differences among groups are determined by ANOVA followed by Tukey’s test.
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| S5304New |
2-Acetylphenothiazine (ML171)2-Acetylphenothiazine (ML171)是一种有效的、选择性的NADPH-oxidase抑制剂，对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。 |
