NADPH-oxidase
抑制剂选择性比较
NADPH-oxidase产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S8639 |
Diphenyleneiodonium chloride (DPI)Diphenyleneiodonium chloride (DPI)是NADPH oxidase的抑制剂，也是有效的、不可逆的iNOS/eNOS抑制剂。 |
||
| S2425 |
ApocyninApocynin是一种选择性NADPH氧化酶抑制剂，IC50 为10 μM. |
NOX inhibition attenuated thyroid morphologic changes of rats. (a) A representative figure from control group; (b) a representative figure from PCB group; (c) a representative figure from PCB + APO group; (d) a representative figure from APO group; (e) histological scores of thyroid tissue. ∗P < 0.05 versus control group. #P < 0.05 versus PCB group (original magnification ×200). |
|
| S7171 |
GKT137831GKT137831是一种有效的双NADPH oxidase NOX1/NOX4抑制剂，Ki分别为110 nM和140 nM。对NOX1、4、5的选择性约为对NOX2的10倍，不抑制XO或ROS/RNS。 |
(C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group). |
|
| S5304 |
2-Acetylphenothiazine (ML171)2-Acetylphenothiazine (ML171)是一种有效的、选择性的NADPH-oxidase抑制剂，对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S8639 |
Diphenyleneiodonium chloride (DPI)Diphenyleneiodonium chloride (DPI)是NADPH oxidase的抑制剂，也是有效的、不可逆的iNOS/eNOS抑制剂。 |
||
| S2425 |
ApocyninApocynin是一种选择性NADPH氧化酶抑制剂，IC50 为10 μM. |
NOX inhibition attenuated thyroid morphologic changes of rats. (a) A representative figure from control group; (b) a representative figure from PCB group; (c) a representative figure from PCB + APO group; (d) a representative figure from APO group; (e) histological scores of thyroid tissue. ∗P < 0.05 versus control group. #P < 0.05 versus PCB group (original magnification ×200). |
|
| S7171 |
GKT137831GKT137831是一种有效的双NADPH oxidase NOX1/NOX4抑制剂，Ki分别为110 nM和140 nM。对NOX1、4、5的选择性约为对NOX2的10倍，不抑制XO或ROS/RNS。 |
(C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group). |
|
| S5304 |
2-Acetylphenothiazine (ML171)2-Acetylphenothiazine (ML171)是一种有效的、选择性的NADPH-oxidase抑制剂，对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。 |
