NADPH-oxidase

抑制剂选择性比较

NADPH-oxidase产品

所有产品 NADPH-oxidase抑制剂(6)

目录号	产品描述	文献引用	实验数据
S8639	Diphenyleneiodonium chloride (DPI) Diphenyleneiodonium chloride (DPI)是NADPH oxidase的抑制剂，也是有效的、不可逆的iNOS/eNOS抑制剂。	Clin Exp Allergy, 2020, 50(2):198-212 Int J Biochem Cell Biol, 2020, 121:105703 Front Immunol, 2019, 10:2636
S6656^New	VAS2870 VAS2870是一种泛NADPH oxidase(NOX)抑制剂。	Clin Sci (Lond), 2020, 17;134(7):853-869
S2425	Apocynin Apocynin是一种选择性NADPH氧化酶抑制剂，IC50 为10 μM.	Commun Biol, 2020, 13;3(1):25 J Exp Clin Cancer Res, 2019, 38(1):225 Oxid Med Cell Longev, 2019, 2019:4578175	NOX inhibition attenuated thyroid morphologic changes of rats. (a) A representative figure from control group; (b) a representative figure from PCB group; (c) a representative figure from PCB + APO group; (d) a representative figure from APO group; (e) histological scores of thyroid tissue. ∗P < 0.05 versus control group. #P < 0.05 versus PCB group (original magnification ×200).
S0178^New	GLX351322 GLX351322 是一种 NADPH oxidase 4 (NOX4) 的抑制剂。GLX351322 可抑制四环素诱导性NOX4过表达细胞的过氧化氢产生，其IC50值为5 μM。
S7171	Setanaxib (GKT137831) GKT137831是一种有效的双NADPH oxidase NOX1/NOX4抑制剂，Ki分别为110 nM和140 nM。对NOX1、4、5的选择性约为对NOX2的10倍，不抑制XO或ROS/RNS。	ACS Nano, 2020, 24;14(3):3059-3074 Redox Biol, 2020, 30;101523 Cell Div, 2020, 1;15:2	(C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group).
S5304	2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171)是一种有效的、选择性的NADPH-oxidase抑制剂，对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。	ACS Nano, 2020, 24;14(3):3059-3074

目录号	产品描述	文献引用	实验数据
S8639	Diphenyleneiodonium chloride (DPI) Diphenyleneiodonium chloride (DPI)是NADPH oxidase的抑制剂，也是有效的、不可逆的iNOS/eNOS抑制剂。	Clin Exp Allergy,2020, 50(2):198-212 Int J Biochem Cell Biol,2020, 121:105703 Front Immunol,2019, 10:2636
S6656^New	VAS2870 VAS2870是一种泛NADPH oxidase(NOX)抑制剂。	Clin Sci (Lond),2020, 17;134(7):853-869
S2425	Apocynin Apocynin是一种选择性NADPH氧化酶抑制剂，IC50 为10 μM.	Commun Biol,2020, 13;3(1):25 J Exp Clin Cancer Res,2019, 38(1):225 Oxid Med Cell Longev,2019, 2019:4578175	NOX inhibition attenuated thyroid morphologic changes of rats. (a) A representative figure from control group; (b) a representative figure from PCB group; (c) a representative figure from PCB + APO group; (d) a representative figure from APO group; (e) histological scores of thyroid tissue. ∗P < 0.05 versus control group. #P < 0.05 versus PCB group (original magnification ×200).
S0178^New	GLX351322 GLX351322 是一种 NADPH oxidase 4 (NOX4) 的抑制剂。GLX351322 可抑制四环素诱导性NOX4过表达细胞的过氧化氢产生，其IC50值为5 μM。
S7171	Setanaxib (GKT137831) GKT137831是一种有效的双NADPH oxidase NOX1/NOX4抑制剂，Ki分别为110 nM和140 nM。对NOX1、4、5的选择性约为对NOX2的10倍，不抑制XO或ROS/RNS。	ACS Nano,2020, 24;14(3):3059-3074 Redox Biol,2020, 30;101523 Cell Div,2020, 1;15:2	(C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group).
S5304	2-Acetylphenothiazine (ML171) 2-Acetylphenothiazine (ML171)是一种有效的、选择性的NADPH-oxidase抑制剂，对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。	ACS Nano,2020, 24;14(3):3059-3074