Rotenone (Barbasco)

For research use only. Not for use in humans.

目录号:S2348 别名: Barbasco, Dactinol, Paraderil, Rotenon, Rotocide 中文名称:鱼藤酮

Rotenone (Barbasco) Chemical Structure

CAS No. 83-79-4

Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) 是一种植物杀虫剂,是线粒体电子传递mitochondrial electron transport的抑制剂。Rotenone 可抑制 NADH/DB oxidoreductaseNADH oxidase,对应的IC50值分别为28.8 nM和5.1 nM。Rotenone 可通过增强线粒体活性氧的产生来诱导凋亡。

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RMB 794.7 现货
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客户使用Selleck生产的Rotenone (Barbasco)发表文献10篇:

产品安全说明书

NADPH-oxidase抑制剂选择性比较

生物活性

产品描述 Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) 是一种植物杀虫剂,是线粒体电子传递mitochondrial electron transport的抑制剂。Rotenone 可抑制 NADH/DB oxidoreductaseNADH oxidase,对应的IC50值分别为28.8 nM和5.1 nM。Rotenone 可通过增强线粒体活性氧的产生来诱导凋亡。
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 NYXj[XM6TnWwY4Tpc44h[XO|YYm= MU\F[oZm[3Rib36gR4RkOiCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHXm[oVkfCCxbjDD[IMzQkOmY{K1R{BqdnSncnHjeIlwdiClb33wcIV5\XNiaX6gdJJme2WwY3Wgc4Yh[2GvcITveIhm[2mwIHL5JGV[TlBiYX7kM49zKFmIUDDW[Y52eyCocnHncYVvfCCkYYPl[EBz\XCxcoTldkBo\W6nIHHzd4F6 NX;DT|Z4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[2PFAyPTlpPkG2OlgxOTV7PD;hQi=>
HEK293 MYLGeY5kfGmxbjDhd5NigQ>? M1PNNWVn\mWldDDvckBE\GN{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOg[YZn\WO2IH;uJGNl[zJ8Q3TjNlVCKGmwdHXyZYN1cW:wIHPvcZBt\XinczDpckBxemW|ZX7j[UBw\iClYX3weI91cGWlaX6gZpkhTVmIUDDhcoQwd3JiWV\QJHZmdnW|IH\yZYdu\W62IHLhd4VlKHKncH;yeIVzKGenbnWgZZN{[Xl? MorLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ4OECxOVkoRjF4NkiwNVU6RC:jPh?=
HEK293 NFztWGdHfW6ldHnvckBie3OjeR?= Mo\2SYZn\WO2IH;uJJA2OyCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHXm[oVkfCCxbjDwOVMueDV|IHnueIVz[WO2aX;uJINwdXCuZYjld{BqdiCycnXz[Y5k\SCxZjDjZY1xfG:2aHXjbY4h[nliRWnGVEBidmRxb4KgXWZRKF[nboXzJIZz[WevZX70JIJie2WmIILldI9zfGW{IHflcoUh[XO|YYm= M1HJV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NkiwNVU6Lz5zNk[4NFE2QTxxYU6=
HEK293 M33ieWZ2dmO2aX;uJIF{e2G7 NIHwbYpKdmirYnn0bY9vKG:oIH;mJIMuUnWwIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKHC{b4TlbY4hcW62ZYLhZ5Rqd25iaX6gdJJme2WwY3Wgc4Yh[2GvcITveIhm[2mwIIfpeIghWGmwMTDifUBGYU[SIHLhd4VlKHKncH;yeIVzKGenbnWgZZN{[Xl? NWjJb5dXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[2PFAyPTlpPkG2OlgxOTV7PD;hQi=>
HEK293 NF[ye2JHfW6ldHnvckBie3OjeR?= M{K2SGVn\mWldDDvckBkd2[rbHnuNUBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJIF{e2W|c3XkJIF{KGWoZnXjeEBwdiClb3\pcIlvOTtiTHntb|IhcW62ZYLhZ5Rqd25iY3;tdIxmgGW|IHnuJJBz\XOnbnPlJI9nKGOjbYD0c5Rp\WOrbjDifUBGYU[SIHHu[E9weiC\RmCgWoVvfXNiZoLh[41mdnRiYnHz[YQhemWyb4L0[ZIh\2WwZTDhd5NigQ>? M4rVRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NkiwNVU6Lz5zNk[4NFE2QTxxYU6=
MG63 M17NVWZ2dmO2aX;uJIF{e2G7 M4H6NlEhfU1? MmPNNUBpeg>? NH;KN|JKdmO{ZXHz[UBqdiCuYXP0ZZRmKHC{b3T1Z5Rqd25iaX6gUWc3OyClZXzsd{BifCBzIIXNJIFnfGW{IEGgbJIh[nliRVzJV2E> M{HCPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEi4OFg6Lz5zN{C4PFQ5QTxxYU6=
U937 M2rvOWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVO3NkBpenN? MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV7M{egZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFeVVD24JIF{e2G7LDDJR|UxRTBwMEhOwG0> NXfwVnY4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexOVgxPTRpPkG3NVU5ODV2PD;hQi=>
U937 M4P2fWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWDSNnl3PDhiaILz NFvnV3lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGW5N|ch[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGfTWE05KGG|c3H5MEBKSzVyPUCuNu69VQ>? M2q0VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUW4NFU1Lz5zN{G1PFA2PDxxYU6=
U937 NVTxfGpNSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MnTuNlQhcHK| MlfVRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOUO3JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCZU2StPEBie3OjeTygTWM2OD1zM988US=> NXiwWXVIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexOVgxPTRpPkG3NVU5ODV2PD;hQi=>
HT1080 NXjIdWtmTnWwY4Tpc44h[XO|YYm= MkTZTY5pcWKrdHnvckBw\iCycn;NUXAzKHC{b3T1Z5Rqd25iaX6gbJVu[W5iSGSxNFgxKGOnbHzzJIJ6KGenbHH0bY4hgnmvb3fyZZBpgSCjbnHsfZNqew>? NGXtSHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G1PFA2PCd-MUexOVgxPTR:L3G+
HT1080 M3\GcWZ2dmO2aX;uJIF{e2G7 NVH4V3JnUW6qaXLpeIlwdiCxZjDwdo9OVVB7IIDyc4R2[3Srb36gbY4hcHWvYX6gTHQyODhyIHPlcIx{KGK7IHflcIF1cW5ieontc4dz[XCqeTDhcoFtgXOrcx?= NH7tdWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G1PFA2PCd-MUexOVgxPTR:L3G+
neural precursor cells M3fPfmZ2dmO2aX;uJIF{e2G7 M1;afWlvcGmkaYTpc44hd2ZibnX1do9{eGincnWgdJJwdGmoZYLheIlwdiCxZjDtc5V{\SCwZYXyZYwheHKnY4Xyd49zKGOnbHzzJIJ6KE2WVDDhd5NigQ>? M13QPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG3OlMyLz5zN{SxO|Y{OTxxYU6=
HepG2 Mn\2RY51cXS3bX;yJIF{e2G7 Ml\YNlQhcHK| M17afmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGVFPTB;MUZOwG0> MnXSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OEK4NlQoRjF5NEiyPFI1RC:jPh?=
A549 M4jRemFvfGm2dX3vdkBie3OjeR?= NV;POlFwOjRiaILz MWHBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFXEOVA:OjcQvF2= M2nlSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEiyPFI1Lz5zN{S4NlgzPDxxYU6=
N548 M4qzWmNmdGxiZHXheIghemW|Y4XlJIF{e2G7 MVvD[YxtKGSnYYToJJJme2O3ZTDpckBz[XRic4TybYF1[WxibnX1do9vKE53NEigcZV1[W62IHPlcIx{NCCHQ{WwQVAvPc7:TR?= MlHlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5Mk[wPVgoRjF5N{K2NFk5RC:jPh?=
ASH neuronal cells NHrueYNE\WyuIHTlZZRpKHKnc3P1[UBie3OjeR?= M3XwTmNmdGxiZHXheIghemW|Y4XlJI9nKEGVSDDu[ZVzd26jbDDj[YxteyCrbjDDZYVvd3KqYXLkbZRqeyCnbHXnZY5{KEi3boTpcod1d25pczDkbZNm[XOnIH3v[IVtNCCHQ{WwQVLPxE1? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzd{NkC5PEc,OTd5Mk[wPVg9N2F-
neuronal cells NWXSXYhTS2WubDDk[YF1cCC{ZYPjeYUh[XO|YYm= Mn3kR4VtdCCmZXH0bEBz\XOldXWgc4YhdmW3cn;uZYwh[2WubIOgbY4h\HKxc3;wbIlt[SCKdX70bY5ofG:wJ4Og[Il{\WG|ZTDtc4RmdCxiRVO1NF0yOM7:TR?= NF7EVZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{eyOlA6QCd-MUe3NlYxQTh:L3G+
N548 MoLjWI95cWOrdImgZZN{[Xl? NHrHdGhVd3irY3n0fUBqdiC{YYSgd5RzcWG2YXygcoV2em:wYXygUlU1QCCvdYThcpQh[2WubIOsJHREPTB;NEFOwG0> NVLBXWx2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NlYxQThpPkG3O|I3ODl6PD;hQi=>
N548 M3TR[mNmdGxiZHXheIghemW|Y4XlJIF{e2G7 MlXzV5VxeHKnc4Ppc44hd2ZiY3XscEBl\WG2aDDpckBz[XRic4TybYF1[WxibnX1do9v[WxiTkW0PEBufXSjboSgZ4VtdHNiYYPz[ZN{\WRiYYOgd5VxeHKnc4Ppc44hd2ZiY3HzdIF{\SB5IHHjeIl3[XSrb36gZpkhX2W|dHXyckBjdG:2dHnu[y=> NWPSfI81RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NlYxQThpPkG3O|I3ODl6PD;hQi=>
N548 M1LSZmFkfGm4YYTpc44hd2ZiRWLLJIlv Mnf4NVAhfU1? MXnBZ5RqfmG2aX;uJI9nKEWUSzDpckBz[XRic4TybYF1[WxibnX1do9v[WxiTkW0PEBufXSjboSgZ4VtdHNiYYSgNVAhfU1iYomgW4V{fGW{bjDicI91fGmwZx?= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzd{NkC5PEc,OTd5Mk[wPVg9N2F-
N548 M1PEVGFkfGm4YYTpc44hd2ZiQVvUJIlv MV2xNEB2VQ>? NHXPcXdC[3SrdnH0bY9vKG:oIFHLWEBqdiC{YYSgd5RzcWG2YXygcoV2em:wYXygUlU1QCCvdYThcpQh[2WubIOgZZQhOTBidV2gZpkhX2W|dHXyckBjdG:2dHnu[y=> M2C2SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{K2NFk5Lz5zN{eyOlA6QDxxYU6=
N548 NGKz[4RC[3SrdnH0bY9vKG:oIFXST{Bqdg>? M{LENVUxKHWP NVfPSJdXSWO2aY\heIlwdiCxZjDFVmshcW5icnH0JJN1emmjdHHsJI5mfXKxbnHsJG42PDhibYX0ZY51KGOnbHzzJIF1KDVyIIXNJIJ6KFenc4Tldo4h[myxdITpcoc> MnXJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5Mk[wPVgoRjF5N{K2NFk5RC:jPh?=
N548 MWXBZ5RqfmG2aX;uJI9nKEGNVDDpci=> MXG1NEB2VQ>? MVXBZ5RqfmG2aX;uJI9nKEGNVDDpckBz[XRic4TybYF1[WxibnX1do9v[WxiTkW0PEBufXSjboSgZ4VtdHNiYYSgOVAhfU1iYomgW4V{fGW{bjDicI91fGmwZx?= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzd{NkC5PEc,OTd5Mk[wPVg9N2F-
N548 M17VOWFkfGm4YYTpc44hd2ZiQVvUJIlv M1rXcVExKHWP NV65[ZBuPiCqcoO= MnfqRYN1cX[jdHnvckBw\iCDS2SgbY4hTE6DLXTl[olkcWWwdDDyZZQhe3S{aXH0ZYwhdmW3cn;uZYwhVjV2ODDteZRidnRiY3XscJMh[XRiMUCgeW0h[W[2ZYKgOkBpenNiYomgW4V{fGW{bjDicI91fGmwZx?= NEf4[mo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{eyOlA6QCd-MUe3NlYxQTh:L3G+
N548 NGTScJpE\WyuIHTlZZRpKHKnc3P1[UBie3OjeR?= MWLD[YxtKGSnYYToJJJme2O3ZTDpckBz[XRic4TybYF1[WxibnX1do9v[WxiTkW0PEBufXSjboSgZ4VtdHNiYomgZ4Ft[2WrbjDhZ4V1d3i7bXX0bJltKGW|dHXyJIF{e2G7 MmDCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5Mk[wPVgoRjF5N{K2NFk5RC:jPh?=
N548 MoPSR4VtdCCmZXH0bEBz\XOldXWgZZN{[Xl? MlHoNVAhfU1? MX63JIRigXN? NXK5ZXh6S2WubDDk[YF1cCC{ZYPjeYUhcW5icnH0JJN1emmjdHHsJI5mfXKxbnHsJG42PDhibYX0ZY51KGOnbHzzJIFv[Wy7c3XkJIV3\XK7IHThfUBnd3JiNzDkZZl{KGG2IEGwJJVOKGK7IITyfZBidiCkbIXlJIR6\S2neHPseZNqd25iYYPzZZk> NUC3fmJQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NlYxQThpPkG3O|I3ODl6PD;hQi=>
N548 MkX1R4VtdCCmZXH0bEBz\XOldXWgZZN{[Xl? M1j5OXN2eHC{ZYPzbY9vKG:oIHPlcIwh\GWjdHigbY4hemG2IIP0dolifGGuIH7leZJwdmGuIF61OFghdXW2YX70JINmdGy|IHHzd4V{e2WmIHHzJJN2eHC{ZYPzbY9vKG:oIHPhd5Bie2ViMzDhZ5RqfmG2aX;uJIJ6KFenc4Tldo4h[myxdITpcoc> M2D5[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{K2NFk5Lz5zN{eyOlA6QDxxYU6=
N548 NIjX[VdE\WyuIHTlZZRpKHKnc3P1[UBie3OjeR?= M37WPVExKHWP M{\PZWNmdGxiZHXheIghemW|Y4XlJIlvKESQQT3k[YZq[2mnboSgdoF1KHO2cnnheIFtKG6ndYLvcoFtKE53NEigcZV1[W62IHPlcIx{KGG2IEGwJJVO MkHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5Mk[wPVgoRjF5N{K2NFk5RC:jPh?=
U373 MG MVXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NXjwNoQ5PzJiaILz M1n3emFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVUO3N{BOTyClZXzsd{Bi\nSncjC3NkBpenN? MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDVzM{m3OEc,OTh3MUO5O|Q9N2F-
T47D MVLGeY5kfGmxbjDhd5NigQ>? M2ryNFAvODBzIITvJFAvOSC3TR?= MmjMTY5pcWKrdHnvckBw\iClZXzseYxieiC{ZYPwbZJifGmxbjDpckBpfW2jbjDUOFdFKGOnbHzzJIF{e2W|c3XkJIF{KHKjdHWgc4Yhd3i7Z3XuJINwdnO3bYD0bY9vKGG2IECuNFAyKHSxIECuNUB2VQ>? Ml;vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{WxNVQoRjJzOEe1NVE1RC:jPh?=
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MG 63 (6-TG R) NGi4bXNyUFSVIHHzd4F6 NEPJS5NyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBOTyB4MzCoOk1VTyCUKTDj[Yxtew>? M4DMO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
fibroblast cells MmnVdWhVWyCjc4PhfS=> NXrDeVN6eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5Ih[2:wdILvcEBJcCC5aXzkJJR6eGViZnnido9jdGG|dDDj[Yxtew>? NWHs[XFyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
OHS-50 M3\SRpFJXFNiYYPzZZk> NF;vWWhyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBQUFNvNUCgZ4VtdHN? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
HepG2 MkLPR5l1d3SxeHnjbZR6KGG|c3H5 MXiyOEBpenN? NH;oOZREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVEvPTMQvF2= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODZzM{OyO{c,OzB4MUOzNlc9N2F-
DLD1 M{[4cWZ2dmO2aX;uJIF{e2G7 NFexboRKdmirYnn0bY9vKG:oIH3peI9kcG:wZILpZYwhd3irZHH0bZZmKHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBFVERzIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBwgHmpZX6gZ49ve3WvcITpc44hemG2ZTDifUB{\WGqb4Lz[UBZTmV7NjDhcoFtgXOncjDiZZNm\CCjc4PhfS=> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTd5NE[3Nkc,OzF5N{S2O|I9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
sestrin2 ; 

PubMed: 26031332     


Mes 23.5 cells were treated with DMSO or rotenone at the indicated concentrations for 12 h. After rotenone treatment, cells were harvested and immunoblotted for sestrin2 protein levels.

p-AMPK / AMPK ; 

PubMed: 26031332     


Cells were treated with rotenone and immunoblotted for phosphorylated AMPK (Thr172) and total AMPK. 

p-mTOR / mTOR / p-S6K1 / S6K1 / p-4EBP1 / 4EBP1 ; 

PubMed: 25304210     


Neuronal cells were treated with (A) rotenone (0–1 μM) for 24 h followed by Western blotting using the indicated antibodies. The blots were probed for β-tubulin as a loading control. 

p-CaMKII / CaMKII ; 

PubMed: 26859572     


Rotenone resulted in phospho-CaMKII increase in a concentration-dependent manner in the cells.

26031332 25304210 26859572
Immunofluorescence
p65 ; 

PubMed: 23977201     


BV2 cells were treated with rotenone for 6 hours or LPS for 1 hour. The cells were fixed and labeled with DAPI (blue) or anti-p65 antibodies (red). The scale bar represents 10 µm.

activated caspase-1 ; 

PubMed: 23977201     


BV2 cells were treated with 1 µM rotenone or 1 µg/mL LPS for 24 hours and then stained with green fluorescent probes for activated caspase-1 for 1 hour. The scale bar represents 10 µm.

23977201
Growth inhibition assay
Cell viability; 

PubMed: 27045591     


PC12 cells were treated with 0~100 μmol/L (μM) rotenone for 24 hours. Cell viability was measured as percentage relative to vehicle (*P < 0.05; **P < 0.01).

27045591

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

体外 DMSO 55 mg/mL (139.44 mM)
Ethanol 2 mg/mL (5.07 mM)
Water Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 394.42
化学式

C23H22O6

CAS号 83-79-4
储存条件 粉状
溶于溶剂
别名 Barbasco, Dactinol, Paraderil, Rotenon, Rotocide

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

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操作手册

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID