Rotenone (Barbasco)

For research use only. Not for use in humans.

目录号:S2348 别名: Barbasco, Dactinol, Paraderil, Rotenon, Rotocide 中文名称:鱼藤酮

Rotenone (Barbasco) Chemical Structure

CAS No. 83-79-4

Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) 是一种植物杀虫剂,是线粒体电子传递mitochondrial electron transport的抑制剂。Rotenone 可抑制 NADH/DB oxidoreductaseNADH oxidase,对应的IC50值分别为28.8 nM和5.1 nM。Rotenone 可通过增强线粒体活性氧的产生来诱导凋亡。

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RMB 794.7 现货
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客户使用Selleck生产的Rotenone (Barbasco)发表文献14篇:

产品安全说明书

NADPH-oxidase抑制剂选择性比较

生物活性

产品描述 Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) 是一种植物杀虫剂,是线粒体电子传递mitochondrial electron transport的抑制剂。Rotenone 可抑制 NADH/DB oxidoreductaseNADH oxidase,对应的IC50值分别为28.8 nM和5.1 nM。Rotenone 可通过增强线粒体活性氧的产生来诱导凋亡。
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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HEK293 NXmyPG1zTnWwY4Tpc44h[XO|YYm= MX7F[oZm[3Rib36gR4RkOiCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHXm[oVkfCCxbjDD[IMzQkOmY{K1RUBqdnSncnHjeIlwdiClb33wcIV5\XNiaX6gdJJme2WwY3Wgc4Yh[2GvcITveIhm[2mwIHL5JGV[TlBiYX7kM49zKFmIUDDW[Y52eyCocnHncYVvfCCkYYPl[EBz\XCxcoTldkBo\W6nIHHzd4F6 M37X[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NkiwNVU6Lz5zNk[4NFE2QTxxYU6=
HEK293 NFfNZ|NHfW6ldHnvckBie3OjeR?= NFnGeWRG\m[nY4Sgc44heDV|IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOg[YZn\WO2IH;uJJA2Oy2yNUOgbY51\XKjY4Tpc44h[2:vcHzlfIV{KGmwIIDy[ZNmdmOnIH;mJINidXC2b4To[YNqdiCkeTDFXWZRKGGwZD;vdkB[TlBiVnXueZMh\nKjZ33lcpQh[mG|ZXSgdoVxd3K2ZYKg[4Vv\SCjc4PhfS=> NGO2cIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNk[4NFE2QSd-MU[2PFAyPTl:L3G+
HEK293 MlSxSpVv[3Srb36gZZN{[Xl? Mli1TY5pcWKrdHnvckBw\iCxZjDjMWp2diCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBxem:2ZXnuJIlvfGW{YXP0bY9vKGmwIIDy[ZNmdmOnIH;mJINidXC2b4To[YNqdiC5aYToJHBqdjFiYomgSXlHWCCkYYPl[EBz\XCxcoTldkBo\W6nIHHzd4F6 NVjXTJd7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[2PFAyPTlpPkG2OlgxOTV7PD;hQi=>
HEK293 M4nYWmZ2dmO2aX;uJIF{e2G7 MlTNSYZn\WO2IH;uJINw\mmuaX6xJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMh\W[oZXP0JI9vKGOxZnnsbY4yQyCOaX3rNkBqdnSncnHjeIlwdiClb33wcIV5\XNiaX6gdJJme2WwY3Wgc4Yh[2GvcITveIhm[2mwIHL5JGV[TlBiYX7kM49zKFmIUDDW[Y52eyCocnHncYVvfCCkYYPl[EBz\XCxcoTldkBo\W6nIHHzd4F6 MoruQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ4OECxOVkoRjF4NkiwNVU6RC:jPh?=
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HT1080 M2XHNmZ2dmO2aX;uJIF{e2G7 MWrJcohq[mm2aX;uJI9nKHC{b13NVFIheHKxZIXjeIlwdiCrbjDoeY1idiCKVEGwPFAh[2WubIOgZpkh\2WuYYTpckB7gW2xZ4LhdIh6KGGwYXz5d4l{ MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3OEC1OEc,OTdzNUiwOVQ9N2F-
HT1080 M1PiO2Z2dmO2aX;uJIF{e2G7 MVLJcohq[mm2aX;uJI9nKHC{b13NVFkheHKxZIXjeIlwdiCrbjDoeY1idiCKVEGwPFAh[2WubIOgZpkh\2WuYYTpckB7gW2xZ4LhdIh6KGGwYXz5d4l{ NVW1cHd7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexOVgxPTRpPkG3NVU5ODV2PD;hQi=>
neural precursor cells NXPX[mZ{TnWwY4Tpc44h[XO|YYm= MW\Jcohq[mm2aX;uJI9nKG6ndYLvd5Bp\XKnIIDyc4xq\mW{YYTpc44hd2ZibX;1d4UhdmW3cnHsJJBz\WO3coPvdkBk\WyuczDifUBOXFRiYYPzZZk> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzN{[zNUc,OTd2MUe2N|E9N2F-
HepG2 M4XzZ2FvfGm2dX3vdkBie3OjeR?= MkjMNlQhcHK| NIjKV2RCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBGTDVyPUG1{txO NVXaOIhLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PFI5OjRpPkG3OFgzQDJ2PD;hQi=>
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MG 63 (6-TG R) NXqyU|JyeUiWUzDhd5NigQ>? NUPsWW5IeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhVUdiNkOgLFYuXEdiUjmgZ4VtdHN? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
fibroblast cells MVPxTHRUKGG|c3H5 MoHOdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgZ49vfHKxbDDIbEB4cWymIIT5dIUh\mmkcn;icIF{fCClZXzsdy=> MonsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
OHS-50 M3rpUJFJXFNiYYPzZZk> M1\CVpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJG9JWy13MDDj[Yxtew>? NH;0Vok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
HepG2 MYDDfZRwfG:6aXPpeJkh[XO|YYm= NXLHRWQ3OjRiaILz Mm[zR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxTzJiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2xMlUz|ryP M1LRVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNkGzN|I4Lz5|ME[xN|MzPzxxYU6=
DLD1 NHricJVHfW6ldHnvckBie3OjeR?= NV7RTlNuUW6qaXLpeIlwdiCxZjDtbZRw[2ixbnTybYFtKG:6aXTheIl3\SCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hTEyGMTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hd3i7Z3XuJINwdnO3bYD0bY9vKHKjdHWgZpkhe2WjaH;yd4UhYE[nOU[gZY5idHm|ZYKgZoF{\WRiYYPzZZk> M33rfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzN{e0OlczLz5|MUe3OFY4OjxxYU6=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
sestrin2 ; 

PubMed: 26031332     


Mes 23.5 cells were treated with DMSO or rotenone at the indicated concentrations for 12 h. After rotenone treatment, cells were harvested and immunoblotted for sestrin2 protein levels.

p-AMPK / AMPK ; 

PubMed: 26031332     


Cells were treated with rotenone and immunoblotted for phosphorylated AMPK (Thr172) and total AMPK. 

p-mTOR / mTOR / p-S6K1 / S6K1 / p-4EBP1 / 4EBP1 ; 

PubMed: 25304210     


Neuronal cells were treated with (A) rotenone (0–1 μM) for 24 h followed by Western blotting using the indicated antibodies. The blots were probed for β-tubulin as a loading control. 

p-CaMKII / CaMKII ; 

PubMed: 26859572     


Rotenone resulted in phospho-CaMKII increase in a concentration-dependent manner in the cells.

26031332 25304210 26859572
Immunofluorescence
p65 ; 

PubMed: 23977201     


BV2 cells were treated with rotenone for 6 hours or LPS for 1 hour. The cells were fixed and labeled with DAPI (blue) or anti-p65 antibodies (red). The scale bar represents 10 µm.

activated caspase-1 ; 

PubMed: 23977201     


BV2 cells were treated with 1 µM rotenone or 1 µg/mL LPS for 24 hours and then stained with green fluorescent probes for activated caspase-1 for 1 hour. The scale bar represents 10 µm.

23977201
Growth inhibition assay
Cell viability; 

PubMed: 27045591     


PC12 cells were treated with 0~100 μmol/L (μM) rotenone for 24 hours. Cell viability was measured as percentage relative to vehicle (*P < 0.05; **P < 0.01).

27045591

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

体外 DMSO 55 mg/mL (139.44 mM)
Ethanol 2 mg/mL (5.07 mM)
Water Insoluble

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 394.42
化学式

C23H22O6

CAS号 83-79-4
储存条件 粉状
溶于溶剂
别名 Barbasco, Dactinol, Paraderil, Rotenon, Rotocide

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

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操作手册

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID