Rotenone

目录号：S2348 批次号：S234804

化学数据

	别名	Barbasco, Dactinol, Paraderil, Rotenon, Rotocide	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₃H₂₂O₆
	分子量	394.42	CAS号	83-79-4
Solubility (25°C)*	体外	DMSO	40 mg/mL (101.41 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述	Rotenone是一种植物杀虫剂，是线粒体电子传递mitochondrial electron transport的抑制剂。Rotenone 可抑制 NADH/DB oxidoreductase 和 NADH oxidase，对应的IC50值分别为28.8 nM和5.1 nM。Rotenone 可通过增强线粒体活性氧的产生来诱导凋亡。

参考文献

Rotenone在文献中得到引用

SPTBN2 suppresses ferroptosis in NSCLC cells by facilitating SLC7A11 membrane trafficking and localization [ Redox Biol, 2024, 70:103039]	PubMed: 38241838
Identifying the potential genes in alpha synuclein driving ferroptosis of Parkinson's disease [ Sci Rep, 2023, 13(1):16893]	PubMed: 37803093
Ginsenoside Rg1 ameliorates chronic intermittent hypoxia-induced vascular endothelial dysfunction by suppressing the formation of mitochondrial reactive oxygen species through the calpain-1 pathway [ J Ginseng Res, 2023, 47(1):144-154]	PubMed: 36644390
Copper induces cell death by targeting lipoylated TCA cycle proteins [ Science, 2022, 375(6586):1254-1261]	PubMed: 35298263
Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis [ Cell Death Dis, 2022, 13(5):436]	PubMed: 35508606
Themis is indispensable for IL-2 and IL-15 signaling in T cells [ Sci Signal, 2022, 15(721):eabi9983]	PubMed: 35167340
Reduction of ROS-HIF1α-driven glycolysis by taurine alleviates Streptococcus uberis infection [ Food Funct, 2022, 10.1039/d1fo03909a]	PubMed: 35112684
Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation [ Sci Rep, 2022, 12(1):11533]	PubMed: 35798783
Low glycaemic diets alter lipid metabolism to influence tumour growth [ Nature, 2021, 10.1038/s41586-021-04049-2]	PubMed: 34671163
SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition [ Cancer Lett, 2021, S0304-3835(21)00167-1]	PubMed: 33872694

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