ROS

抑制剂选择性比较

ROS产品

所有产品 ROS抑制剂(11) ROS激活剂(2) ROS调节剂(1) ROS化学产品(16)

产品目录	产品描述	文献引用	实验数据
S1068	Crizotinib (PF-02341066) Crizotinib (PF-02341066) 克唑替尼是一种有效的c-Met和ALK抑制剂，在细胞试验中IC50分别为11 nM 和 24 nM。它同时也是有效的ROS1抑制剂，其Ki值小于0.025 nM。	Int J Mol Sci, 215, 16(1):2174-86 Cell, 2019, 36(2):179-193 Cancer Cell, 2019, 36(2):179-193	(c) Western blot analyses of p-Akt (Ser473) and p-S6RP (Ser235 and Ser236) in two RCT-E565 transplanted tumors treated with vehicle or PF02341066. Samples were isolated 4 h after the last dose from mice treated with PF02341066 for 3 d. (d) Responses of RCT-E565 transplanted tumors in athymic mice to PF02341066 or vehicle. Data are means ±s.e.m. (each group, n = 6). P < 0.005, *P < 0.001 (Student^,s t test).
S1547	Febuxostat Febuxostat 是一种非嘌呤，选择性黄嘌呤氧化酶抑制剂，IC50为114-210 nM。	Redox Biol, 2018, 16:157-168 Br J Pharmacol, 2016, 173(14):2290-302 Free Radic Biol Med, 2015, 10.1016/j.freeradbiomed.2015.02.016	NOX activity was measured as lucigenin-dependent chemiluminescence of superoxide. Incubation with febuxostat increased superoxide generation in nonactivated macrophages, but did not significantly influence superoxide formation in LPS-activated macrophages. Simultaneous treatment with febuxostat abolished the effect of nitrite during activation with LPS. Data are means±SEM (n=10-12). *, p<0.05. LPS, lipopolysaccharide (10 ng/ml); NO2, sodium nitrite (10 μM); febuxostat, xanthine oxidase inhibitor (30 nM).
S1623	Acetylcysteine Acetylcysteine(N-acetyl-l-cysteine)是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可处理扑热息痛(对乙酰氨基酚)过量。	Cell Syst, 2019, 8(2):97-108 Redox Biol, 2019, 22:101116 Redox Biol, 2019, 22:101157	(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
S1630	Allopurinol Allopurinol 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。	Nature, 2018, 560(7718):372-376 Cell Physiol Biochem, 2018, 47(5):1800-1808
S3616	Asiaticoside Asiaticoside是Centella asiatica（积雪草）中的主要活性成分，通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。
S3631	(S)-Methylisothiourea sulfate (S)-Methylisothiourea sulfate是iNOS的抑制剂。
S3973	L-SelenoMethionine L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.
S4603	Gallic acid Gallic acid是一种在多种食物和草药中发现的有机酸，是有效的抗氧化剂。
S1631	Allopurinol Sodium Allopurinol Sodium 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。
S4074	Sodium Nitrite Sodium Nitrite是一种绿过氧物酶抑制剂，IC50为 1.3 μM。
S9107	Glycitein Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.
S5263	Pyrroloquinoline Quinone Disodium Salt Pyrroloquinoline quinone, an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions.
S3607	Sarsasapogenin Sarsasapogenin (SAR)是一种甾体皂甙元，能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活，在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。
S2399	Dihydromyricetin Dihydromyricetin 是具有良好性能的天然抗氧化剂。	Fundam Clin Pharmacol, 2016, 30(6):596-606 Oncotarget, 2016, 10.18632/oncotarget.10836 Food Chem Toxicol, 2012, 50(7):2508-14	ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation.
S2605	Idebenone Idebenone是一种辅酶Q10（CoQ10）的合成类似物，是一种大脑兴奋剂。
S2062	Tiopronin Tiopronin是美国食品和药物管理局（FDA）批准的用于治疗治疗胱氨酸尿症的药物，通过控制胱氨酸沉淀和排泄速率。
S4580	Hydroquinone Hydroquinone是黑色素合成抑制剂。Hydroquinone的生理效应通过其褪色活性发挥。它还具有抗氧化特性，在多个器官中，尤其是肾脏中产生毒性作用。
S3632	Trichloroisocyanuric acid TrichloroisTrichloroisocyanuric acid (TCCA)是一种安全有效的试剂，作用于氯化作用和氧化反应。
S3838	Carnosic acid Carnosic acid is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.
S3840	Baohuoside I Baohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.
s9021	(20R)Ginsenoside Rg3 (20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.
s9034	Isochlorogenic acid C Isochlorogenic acid C, which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.
S2332	Neohesperidin Neohesperidin 是一种抗氧化剂，在1,1-diphenyl-2-picryldydrazyl（DPPH）自由基清除测定中，IC50为22.31 μg/ml。
S3885	Pyrogallol Pyrogallol, an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.
S4511	6-Benzylaminopurine 6-Benzylaminopurine是第一代合成的细胞分裂素，可调节植物的抗氧化系统的活性。它对植物的生长和发育有一定促进作用。
S7551	Piperlongumine Piperlongumine，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。	Cancer Cell, 2019, 36(2):179-193 Cell, 2019, 36(2):179-193 Cell Rep, 2019, 28(2):512-525.e6	a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. P < 0.05; P < 0.01; **P < 0.001.
S7867	Oleuropein Oleuropein是一种从橄榄叶中分离出的抗氧化多酚。Phase 2。
S2363	Tangeretin Tangeretin 是一种柑橘类黄酮。	J Cell Physiol, 2018, 10.1002/jcp.27651
S4722	(+)-Catechin Cianidanol是抗氧化类黄酮，主要以(+)-catechin和(-)-epicatechin的形式存在于木本植物中。
S4723	(-)Epicatechin (−)Epicatechin是一种类黄酮，在可可、绿茶、红酒中常见。具有强的抗氧化、胰岛素类似作用，能改善心脏健康。

产品目录	产品描述	文献引用	实验数据
S1068	Crizotinib (PF-02341066) Crizotinib (PF-02341066) 克唑替尼是一种有效的c-Met和ALK抑制剂，在细胞试验中IC50分别为11 nM 和 24 nM。它同时也是有效的ROS1抑制剂，其Ki值小于0.025 nM。	Int J Mol Sci,215, 16(1):2174-86 Cell,2019, 36(2):179-193 Cancer Cell,2019, 36(2):179-193	(c) Western blot analyses of p-Akt (Ser473) and p-S6RP (Ser235 and Ser236) in two RCT-E565 transplanted tumors treated with vehicle or PF02341066. Samples were isolated 4 h after the last dose from mice treated with PF02341066 for 3 d. (d) Responses of RCT-E565 transplanted tumors in athymic mice to PF02341066 or vehicle. Data are means ±s.e.m. (each group, n = 6). P < 0.005, *P < 0.001 (Student^,s t test).
S1547	Febuxostat Febuxostat 是一种非嘌呤，选择性黄嘌呤氧化酶抑制剂，IC50为114-210 nM。	Redox Biol,2018, 16:157-168 Br J Pharmacol,2016, 173(14):2290-302 Free Radic Biol Med,2015, 10.1016/j.freeradbiomed.2015.02.016	NOX activity was measured as lucigenin-dependent chemiluminescence of superoxide. Incubation with febuxostat increased superoxide generation in nonactivated macrophages, but did not significantly influence superoxide formation in LPS-activated macrophages. Simultaneous treatment with febuxostat abolished the effect of nitrite during activation with LPS. Data are means±SEM (n=10-12). *, p<0.05. LPS, lipopolysaccharide (10 ng/ml); NO2, sodium nitrite (10 μM); febuxostat, xanthine oxidase inhibitor (30 nM).
S1623	Acetylcysteine Acetylcysteine(N-acetyl-l-cysteine)是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可处理扑热息痛(对乙酰氨基酚)过量。	Cell Syst,2019, 8(2):97-108 Redox Biol,2019, 22:101116 Redox Biol,2019, 22:101157	(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
S1630	Allopurinol Allopurinol 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。	Nature,2018, 560(7718):372-376 Cell Physiol Biochem,2018, 47(5):1800-1808
S3616	Asiaticoside Asiaticoside是Centella asiatica（积雪草）中的主要活性成分，通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。
S3631	(S)-Methylisothiourea sulfate (S)-Methylisothiourea sulfate是iNOS的抑制剂。
S3973	L-SelenoMethionine L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.
S4603	Gallic acid Gallic acid是一种在多种食物和草药中发现的有机酸，是有效的抗氧化剂。
S1631	Allopurinol Sodium Allopurinol Sodium 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。
S4074	Sodium Nitrite Sodium Nitrite是一种绿过氧物酶抑制剂，IC50为 1.3 μM。
S9107	Glycitein Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.

产品目录	产品描述	文献引用	实验数据
S5263	Pyrroloquinoline Quinone Disodium Salt Pyrroloquinoline quinone, an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions.
S3607	Sarsasapogenin Sarsasapogenin (SAR)是一种甾体皂甙元，能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活，在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。

产品目录

产品描述

文献引用

实验数据

S5263

Pyrroloquinoline Quinone Disodium Salt

Pyrroloquinoline quinone, an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions.

S3607

Sarsasapogenin

Sarsasapogenin (SAR)是一种甾体皂甙元，能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活，在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。

产品目录	产品描述	文献引用	实验数据
S2399	Dihydromyricetin Dihydromyricetin 是具有良好性能的天然抗氧化剂。	Fundam Clin Pharmacol, 2016, 30(6):596-606 Oncotarget, 2016, 10.18632/oncotarget.10836 Food Chem Toxicol, 2012, 50(7):2508-14	ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation.

产品目录

产品描述

文献引用

实验数据

S2399

Dihydromyricetin

Dihydromyricetin 是具有良好性能的天然抗氧化剂。

Fundam Clin Pharmacol, 2016, 30(6):596-606

Oncotarget, 2016, 10.18632/oncotarget.10836

Food Chem Toxicol, 2012, 50(7):2508-14

产品目录	产品描述	文献引用	实验数据
S2605	Idebenone Idebenone是一种辅酶Q10（CoQ10）的合成类似物，是一种大脑兴奋剂。
S2062	Tiopronin Tiopronin是美国食品和药物管理局（FDA）批准的用于治疗治疗胱氨酸尿症的药物，通过控制胱氨酸沉淀和排泄速率。
S4580	Hydroquinone Hydroquinone是黑色素合成抑制剂。Hydroquinone的生理效应通过其褪色活性发挥。它还具有抗氧化特性，在多个器官中，尤其是肾脏中产生毒性作用。
S3632	Trichloroisocyanuric acid TrichloroisTrichloroisocyanuric acid (TCCA)是一种安全有效的试剂，作用于氯化作用和氧化反应。
S3838	Carnosic acid Carnosic acid is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.
S3840	Baohuoside I Baohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.
s9021	(20R)Ginsenoside Rg3 (20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.
s9034	Isochlorogenic acid C Isochlorogenic acid C, which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.
S2332	Neohesperidin Neohesperidin 是一种抗氧化剂，在1,1-diphenyl-2-picryldydrazyl（DPPH）自由基清除测定中，IC50为22.31 μg/ml。
S3885	Pyrogallol Pyrogallol, an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.
S4511	6-Benzylaminopurine 6-Benzylaminopurine是第一代合成的细胞分裂素，可调节植物的抗氧化系统的活性。它对植物的生长和发育有一定促进作用。
S7551	Piperlongumine Piperlongumine，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。	Cancer Cell, 2019, 36(2):179-193 Cell, 2019, 36(2):179-193 Cell Rep, 2019, 28(2):512-525.e6	a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. P < 0.05; P < 0.01; **P < 0.001.
S7867	Oleuropein Oleuropein是一种从橄榄叶中分离出的抗氧化多酚。Phase 2。
S2363	Tangeretin Tangeretin 是一种柑橘类黄酮。	J Cell Physiol, 2018, 10.1002/jcp.27651
S4722	(+)-Catechin Cianidanol是抗氧化类黄酮，主要以(+)-catechin和(-)-epicatechin的形式存在于木本植物中。
S4723	(-)Epicatechin (−)Epicatechin是一种类黄酮，在可可、绿茶、红酒中常见。具有强的抗氧化、胰岛素类似作用，能改善心脏健康。

研究领域

产品类型

ROS

抑制剂选择性比较

ROS产品