ROS
抑制剂选择性比较
ROS产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S1547 |
FebuxostatFebuxostat (TMX 67, TEI-6720) 是一种非嘌呤,选择性黄嘌呤氧化酶抑制剂,IC50为114-210 nM。 |
![]() ![]() NOX activity was measured as lucigenin-dependent chemiluminescence of superoxide. Incubation with febuxostat increased superoxide generation in nonactivated macrophages, but did not significantly influence superoxide formation in LPS-activated macrophages. Simultaneous treatment with febuxostat abolished the effect of nitrite during activation with LPS. Data are means±SEM (n=10-12). *, p<0.05. LPS, lipopolysaccharide (10 ng/ml); NO2, sodium nitrite (10 μM); febuxostat, xanthine oxidase inhibitor (30 nM). |
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S1623 |
Acetylcysteine (N-acetylcysteine)Acetylcysteine (N-acetyl-l-cysteine, NAC)是ROS抑制剂,拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂,主要用作祛痰剂,可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用。 |
![]() ![]() (C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
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S1630 |
AllopurinolAllopurinol 是一种黄嘌呤氧化酶抑制剂,IC50为7.82±0.12 μM。 |
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S3590New |
TrioleinTriolein 是一种 metalloproteinase-1 (MMP-1) 的抑制剂,可降低辐射角化细胞中 IL-6 和 ROS 的表达。 |
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S3578New |
Pyrroloquinoline quinonePyrroloquinoline quinone (PQQ, Methoxatin) 是一种天然的抗氧化剂,具有抗氧化和抗衰老的作用。Pyrroloquinoline quinone 可预防雌激素缺乏引起的骨质疏松症。 |
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S6920New |
SEA0400SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂,可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收,对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERK 和 p38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。 |
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S3205New |
PerillaldehydePerillaldehyde (Perilladehyde, Perillal, PAE, PA) 是紫苏 Perilla frutescens(一种传统的抗氧化剂)的主要成分,可抑制BaP诱导的 AHR 的活化和 ROS 的产生,抑制 BaP/AHR 介导的 CCL2 chemokine 的释放,并激活 NRF2/HO1 抗氧化剂途径。 |
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S8974New |
GSK2795039GSK2795039 是 NADPH oxidase 2 (NOX2) 的抑制剂,对于NOX2介导的HRP/Amplex Red的激活的pIC50值为6.57。GSK2795039 可抑制活性氧reactive oxygen species (ROS)的产生,NADPH的消耗并减少细胞凋亡。 |
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S8978New |
Mitoquinone mesylateMitoquinone mesylate (MitoQ mesylate, MitoQ10, Mitoubiquinone) 是一种基于TPP的线粒体mitochondria靶向抗氧化剂,可阻断H2O2诱导的细胞内 ROS 反应并防止氧化损伤。 |
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S3616 |
AsiaticosideAsiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol) 是Centella asiatica(积雪草)中的主要活性成分,通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。 |
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S3631 |
(S)-Methylisothiourea sulfate(S)-Methylisothiourea sulfate是iNOS的抑制剂。 |
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S4017 |
AllylthioureaAllylthiourea是一种代谢抑制剂,选择性抑制ammonia oxidation(氨氧化)。 |
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S6281 |
Sodium ThiocyanateSodium Thiocyanate (NaSCN, Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate)是硫氰酸盐阴离子的主要来源之一,被用作合成药物和其他专用化学品的前体。Sodium Thiocyanate (NaSCN) 降低 IL-6,而增加 IL-10 的表达水平。Sodium Thiocyanate 还可以降低 ROS 水平。 |
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S4853 |
Ecabet sodiumEcabet sodium (TA-2711, TA-2711E) is a widely employed mucoprotective agent for the treatment of gastric ulcers. |
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S8639 |
Diphenyleneiodonium chloride (DPI)Diphenyleneiodonium chloride (DPI)是 NADPH oxidase 的抑制剂,也是有效的、不可逆的 iNOS/eNOS 抑制剂。Diphenyleneiodonium chloride (DPI) 还起到 TRPA1 激活剂的作用,并能选择性地抑制细胞内的活性氧(ROS)。 |
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S3816 |
DehydroevodiamineDehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells. |
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S5771 |
SulforaphaneSulforaphane 是一种天然存在的异硫氰酸盐,存在于十字花科蔬菜如西兰花、卷心菜、羽衣甘蓝。它是 Nrf2 的诱导物。Sulforaphane 也是 histone deacetylase (HDAC) 和 NF-κB 的抑制剂。Sulforaphane 可增加 heme oxygenase-1 (HO-1),并降低 reactive oxygen species (ROS) 的水平。Sulforaphane 诱导细胞周期停滞和凋亡。 |
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S3973 |
L-SelenoMethionineL-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense. |
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S4603 |
Gallic acidGallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid)是一种在多种食物和草药中发现的有机酸,是有效的抗氧化剂。 |
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S1631 |
Allopurinol SodiumAllopurinol Sodium 是一种黄嘌呤氧化酶抑制剂,IC50为7.82±0.12 μM。 |
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S9107 |
GlyciteinGlycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities. |
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S7171 |
Setanaxib (GKT137831)Setanaxib (GKT137831, GKT831) 是一种有效的双NADPH oxidase NOX1/NOX4抑制剂,Ki分别为110 nM和140 nM。GKT137831 处理可抑制 reactive oxygen species (ROS) 的产生。GKT137831 可一定程度上抑制铁死亡。 |
![]() ![]() (C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group). |
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S2369 |
TroxerutinTroxerutin 是一种黄酮醇类,是一种黄酮类化合物。 |
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S7873 |
Disodium (R)-2-HydroxyglutarateDisodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium)是一种竞争性α-ketoglutarate-dependent dioxygenases抑制剂,其 Ki值为10.87 ± 1.85 mM。 |
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S1046 |
Vandetanib (ZD6474)Vandetanib (ZD6474) 是一种有效的 VEGFR2 抑制剂,在无细胞试验中IC50为40 nM。同时,也抑制VEGFR3和EGFR,IC50分别为110 nM 和500 nM。对PDGFRβ, Flt-1, Tie-2 和FGFR1作用效果不大,IC50为 1.1-3.6 μM, 对MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt 和 IGF-1R几乎没有作用效果,IC50>10 μM。Vandetanib (ZD6474) 可增加凋亡并通过提高 reactive oxygen species (ROS) 的水平来诱导自噬。 |
![]() ![]() Vandetanib reduced extracellular nitrite levels in endothelial cells. MS1 endothelial cells (ECs) were incubated with 1 mol/L of vandetanib or matched vehicle (dimethyl sulfoxide [DMSO]), 50 ng/mL of vascular endothelial growth factor (VEGF) or matched vehicle (PBS; 0.5 hours), and L-arginine and soluble N-ethylmaleamide sensitive factor attachment protein (SNAP) added (1.5 hours). Vandetanib lowered nitrite levels in MS1 Ecs (*P0.0003). VEGF was used a positive control and increased nitrite levels (**P0.02). These findings indicate that vandetanib lowered endothelial cell NO levels. |
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S2843 |
BI-D1870BI-D1870是一种ATP-竞争性S6 ribosome抑制剂,在无细胞试验中作用于RSK1/2/3/K4,IC50分别为31 nM/24 nM/18 nM/15 nM,作用于RSK比作用于MST2,GSK-3β,MARK3,CK1和Aurora B选择性高10到100倍。BI-D1870 显示除了抗癌的属性包括活性氧的生成、提高内质网应激反应和诱导自噬。 |
![]() ![]() Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.
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S4425New |
Rifamycin SRifamycin S 是一种quinone和抗 Gram-positive bacteria(包括MRSA) 的抗生素,是一种用于治疗肺结核和麻风病的临床药物。Rifamycin S 可产生 reactive oxygen species (ROS),并抑制微粒体脂质过氧化 microsomal lipid peroxidation。 |
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S3357New |
Elaidic acidElaidic acid 是一种主要的反式脂肪酸,可抑制细胞活力,并通过增强氧化应激 oxidative stress 来促进细胞的凋亡。Elaidic acid 可用作药物溶剂。 |
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S3238New |
ResibufogeninResibufogenin (Bufogenin, Recibufogenin) 是huachansu华蟾素中具有抗癌作用的成分,通过上调 receptor-interacting protein kinase 3 (RIP3) 和磷酸化 mixed lineage kinase domain-like protein 的Ser358位点来触发坏死病。Resibufogenin 可通过诱导 reactive oxygen species (ROS) 积累发挥细胞毒性作用。Resibufogenin 可诱导凋亡和 caspase-3 和 caspase-8 活性。Resibufogenin 增加 Bax/Bcl-2 表达,并抑制 cyclin D1、cyclin E、PI3K、p-AKT、p-GSK3β 和 β-catenin 的蛋白表达。 |
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S6871New |
Sodium oxamateSodium oxamate (SO, Aminooxoacetic acid, Oxamic acid)是一种 lactate dehydrogenase (LDH) 的抑制剂,可特异性地抑制LDH‑A。Sodium oxamate (SO) 通过下调 CDK1/cyclin B1 途径诱导G2/M细胞周期停滞,并通过增加线粒体内 ROS 的生成来促进凋亡。 |
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S9611New |
ABTL-0812ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) 可在肺鳞癌细胞系中通过诱导TRIB3的过表达和激活自噬来抑制 Akt/mTOR 轴。ABTL0812 还可诱导 AMPK 激活和 ROS 积累。 |
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S0770New |
CamalexinCamalexin, a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae), can induce reactive oxygen species (ROS) production. Camalexin has antibacterial, antifungal, antiproliferative and anticancer activities. |
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S5452 |
Sanguinarine chlorideSanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. |
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S7309 |
BAY 87-2243BAY 87-2243 是一种有效的选择性hypoxia-inducible factor-1 (HIF-1)抑制剂。BAY 87-2243 可抑制 mitochondrial complex I 的活性,从而触发依赖线粒体的ROS升高,导致细胞坏死和铁死亡ferroptosis。BAY 87-2243 具有抗肿瘤活性。Phase 1。 |
![]() ![]() Cells were plated at low density, treated with the indicated compounds and scored for resistance. Abbreviations: osimertinib (Osi), phenformin (Phen), metformin (Met), buformin (Buf), BAY 87-2243 (BAY), oligomycin (Oligo).
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S0056 |
(E/Z)-BCI(E/Z)-BCI (BCI, NSC 150117) 是一种 dual specific phosphatase 1/6 (DUSP1/DUSP6) 和 mitogen-activated protein kinase 的抑制剂,对细胞中DUSP6和DUSP1的EC50值分别为13.3 μM和8.0 μM。(E)-BCI 在H1299肺癌细胞中通过产生 reactive oxygen species (ROS) 和激活内在的线粒体途径来诱导凋亡。 |
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S5263 |
Pyrroloquinoline Quinone Disodium SaltPyrroloquinoline quinone (methoxatin disodium salt), an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions. |
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S2271 |
Berberine chlorideBerberine chloride (Natural Yellow 18 chloride)是异喹啉类生物碱的季铵盐。Berberine chloride 可激活 caspase 3 和 caspase 8,分裂 poly ADP-ribose polymerase (PARP) 和释放 cytochrome c。Berberine chloride 可降低 c-IAP1,Bcl-2 和 Bcl-XL 的表达。Berberine chloride 可通过 JNK 和 p38 MAPK 的持续磷酸化以及产生 ROS 来诱导凋亡。Berberine chloride 是一个 topoisomerase I 和 II 的双效抑制剂。Berberine chloride 也是一个潜在的自噬调节剂。 |
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S8615 |
Sodium dichloroacetate (DCA)Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA)是 pyruvate dehydrogenase kinase (PDK) 的特异性抑制剂,对PDK2和PDK4的IC50值分别为183和80 μM;可抑制 Na+-K+-2Cl- cotransporter 和线粒体钾离子通道轴。Sodium dichloroacetate 可增加活性氧的生成,引起癌细胞凋亡,并抑制肿瘤生长。 |
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S3607 |
SarsasapogeninSarsasapogenin (SAR, Parigenin)是一种甾体皂甙元,能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活,在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。 |
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S2348 |
Rotenone (Barbasco)Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) 是一种植物杀虫剂,是线粒体电子传递mitochondrial electron transport的抑制剂。Rotenone 可抑制 NADH/DB oxidoreductase 和 NADH oxidase,对应的IC50值分别为28.8 nM和5.1 nM。Rotenone 可通过增强线粒体活性氧的产生来诱导凋亡。 |
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S5584 |
CitronellolCitronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells. |
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S8661 |
CA3 (CIL56)CA3 (CIL56) 对YAP1/Tead转录活性具有有效的抑制作用,主要靶向高表达YAP1、具有癌症干细胞属性的、难治疗的食管腺癌细胞。CA3(CIL56)可诱导铁死亡和铁依赖的活性氧自由基。 |
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S4419New |
EnsulizoleEnsulizole (PBSA) 是一种水溶性防晒成分,一种磺化的UV吸收剂,其特征是可强烈吸收UVB和部分吸收UVA。Ensulizole 可以通过紫外线或日光照射下 reactive oxygen species (ROS) 的生成来破坏DNA。 |
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S3301New |
CynarinCynarin (Cynarine) 是一种来自artichoke洋蓟的植物化学成分,具有多种药理特性,包括自由基清除、抗氧化剂、抗组氨酸和抗病毒活性。Cynarin 可阻断T细胞受体的 CD28 和抗原呈递细胞的 CD80 之间的相互作用。Cynarin 可触发 Nrf2 的核易位,恢复 glutathione (GSH) 和 reactive oxygen species (ROS) 的平衡,并抑制线粒体去极化。 |
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S5804 |
N-Acetylcysteine amideN-acetylcysteine amide是一种能穿透细胞膜的抗氧化剂,具有消炎活性,能够调节NF-κB的激活、HIF-1α和ROS。 |
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S2399 |
DihydromyricetinDihydromyricetin (Ampelopsin, Ampeloptin)是具有良好性能的天然抗氧化剂。 |
![]() ![]() ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation. |
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S4263 |
Efaproxiral SodiumEfaproxiral Sodium是一种人工合成的血红素异构修饰剂,用于乳腺癌脑转移瘤的治疗。 |
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S3222New |
Raspberry ketone glucosideRaspberry ketone glucoside (RKG) 是来源于树莓果实的天然产物,是一种抗氧化剂antioxidant,对黑色素 melanin 的合成具有抑制作用。 |
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S9687New |
H2DCFDAH2DCFDA (DCFH-DA, 2',7'-Dichlorodihydrofluorescein diacetate) 是一种可渗透细胞的探针,可用于检测细胞内 reactive oxygen species (ROS) 的产生。 |
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S2605 |
IdebenoneIdebenone (CV-2619) 是一种辅酶Q10(CoQ10)的合成类似物,是一种大脑兴奋剂。 |
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S2062 |
TioproninTiopronin是美国食品和药物管理局(FDA)批准的用于治疗治疗胱氨酸尿症的药物,通过控制胱氨酸沉淀和排泄速率。 |
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S4580 |
HydroquinoneHydroquinone (Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ)是黑色素合成抑制剂。Hydroquinone的生理效应通过其褪色活性发挥。它还具有抗氧化特性,在多个器官中,尤其是肾脏中产生毒性作用。 |
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S4970 |
NerolNerol (Cis-Geraniol, Neryl alcohol)是存在于多种香精油如柠檬草和槐花中的单萜化合物。 |
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S5314 |
HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone)HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone), which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent. |
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S3838 |
Carnosic acidCarnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries. |
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S3840 |
Baohuoside IBaohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway. |
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S9021 |
(20R)Ginsenoside Rg3(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite. |
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S9034 |
Isochlorogenic acid CIsochlorogenic acid C (3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid), which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71. |
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S2332 |
NeohesperidinNeohesperidin (NSC 31048) 是一种抗氧化剂,在1,1-diphenyl-2-picryldydrazyl(DPPH)自由基清除测定中,IC50为22.31 μg/ml。 |
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S3885 |
PyrogallolPyrogallol (1,2,3-trihydroxybenzene), an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer. |
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S4511 |
6-Benzylaminopurine6-Benzylaminopurine是第一代合成的细胞分裂素,可调节植物的抗氧化系统的活性。它对植物的生长和发育有一定促进作用。 |
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S7551 |
PiperlonguminePiperlongumine (PPLGM, Piplartine),存在于胡椒科植物荜茇中的一种天然生物碱,能够增加reactive oxygen species (ROS)水平,并选择性杀死癌细胞。它还是TrxR1的直接抑制剂,对胃癌具有抑制活性;一种新型的CRM1抑制剂;在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。 |
![]() ![]() a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. *P < 0.05; **P < 0.01; ***P < 0.001.
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S7867 |
OleuropeinOleuropein 是一种从橄榄叶中分离出的抗氧化多酚。Oleuropein 具有抗氧化、抗炎和抗动脉粥样硬化的作用,并在体外抑制脂肪细胞的分化。Oleuropein 抑制 PPARγ 活性。Oleuropein 通过直接抑制PPARγ转录活性发挥抗脂肪形成作用。Oleuropein 还可抑制aromatase。Oleuropein 可诱导凋亡。Phase 2。 |
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S2363 |
TangeretinTangeretin (Tangeritin)是一种柑橘类黄酮。 |
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S4722 |
(+)-Catechin(+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) 是抗氧化类黄酮,主要以(+)-catechin和(-)-epicatechin的形式存在于木本植物中。 |
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S4723 |
(-)Epicatechin(−)Epicatechin (L-Epicatechin, (-)-Epicatechol)是一种类黄酮,在可可、绿茶、红酒中常见。具有强的抗氧化、胰岛素类似作用,能改善心脏健康。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S1547 |
FebuxostatFebuxostat (TMX 67, TEI-6720) 是一种非嘌呤,选择性黄嘌呤氧化酶抑制剂,IC50为114-210 nM。 |
![]() ![]() NOX activity was measured as lucigenin-dependent chemiluminescence of superoxide. Incubation with febuxostat increased superoxide generation in nonactivated macrophages, but did not significantly influence superoxide formation in LPS-activated macrophages. Simultaneous treatment with febuxostat abolished the effect of nitrite during activation with LPS. Data are means±SEM (n=10-12). *, p<0.05. LPS, lipopolysaccharide (10 ng/ml); NO2, sodium nitrite (10 μM); febuxostat, xanthine oxidase inhibitor (30 nM). |
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S1623 |
Acetylcysteine (N-acetylcysteine)Acetylcysteine (N-acetyl-l-cysteine, NAC)是ROS抑制剂,拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂,主要用作祛痰剂,可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用。 |
![]() ![]() (C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
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S1630 |
AllopurinolAllopurinol 是一种黄嘌呤氧化酶抑制剂,IC50为7.82±0.12 μM。 |
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S3590New |
TrioleinTriolein 是一种 metalloproteinase-1 (MMP-1) 的抑制剂,可降低辐射角化细胞中 IL-6 和 ROS 的表达。 |
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S3578New |
Pyrroloquinoline quinonePyrroloquinoline quinone (PQQ, Methoxatin) 是一种天然的抗氧化剂,具有抗氧化和抗衰老的作用。Pyrroloquinoline quinone 可预防雌激素缺乏引起的骨质疏松症。 |
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S6920New |
SEA0400SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂,可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收,对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERK 和 p38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。 |
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S3205New |
PerillaldehydePerillaldehyde (Perilladehyde, Perillal, PAE, PA) 是紫苏 Perilla frutescens(一种传统的抗氧化剂)的主要成分,可抑制BaP诱导的 AHR 的活化和 ROS 的产生,抑制 BaP/AHR 介导的 CCL2 chemokine 的释放,并激活 NRF2/HO1 抗氧化剂途径。 |
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S8974New |
GSK2795039GSK2795039 是 NADPH oxidase 2 (NOX2) 的抑制剂,对于NOX2介导的HRP/Amplex Red的激活的pIC50值为6.57。GSK2795039 可抑制活性氧reactive oxygen species (ROS)的产生,NADPH的消耗并减少细胞凋亡。 |
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S8978New |
Mitoquinone mesylateMitoquinone mesylate (MitoQ mesylate, MitoQ10, Mitoubiquinone) 是一种基于TPP的线粒体mitochondria靶向抗氧化剂,可阻断H2O2诱导的细胞内 ROS 反应并防止氧化损伤。 |
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S3616 |
AsiaticosideAsiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol) 是Centella asiatica(积雪草)中的主要活性成分,通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。 |
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S3631 |
(S)-Methylisothiourea sulfate(S)-Methylisothiourea sulfate是iNOS的抑制剂。 |
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S4017 |
AllylthioureaAllylthiourea是一种代谢抑制剂,选择性抑制ammonia oxidation(氨氧化)。 |
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S6281 |
Sodium ThiocyanateSodium Thiocyanate (NaSCN, Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate)是硫氰酸盐阴离子的主要来源之一,被用作合成药物和其他专用化学品的前体。Sodium Thiocyanate (NaSCN) 降低 IL-6,而增加 IL-10 的表达水平。Sodium Thiocyanate 还可以降低 ROS 水平。 |
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S4853 |
Ecabet sodiumEcabet sodium (TA-2711, TA-2711E) is a widely employed mucoprotective agent for the treatment of gastric ulcers. |
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S8639 |
Diphenyleneiodonium chloride (DPI)Diphenyleneiodonium chloride (DPI)是 NADPH oxidase 的抑制剂,也是有效的、不可逆的 iNOS/eNOS 抑制剂。Diphenyleneiodonium chloride (DPI) 还起到 TRPA1 激活剂的作用,并能选择性地抑制细胞内的活性氧(ROS)。 |
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S3816 |
DehydroevodiamineDehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells. |
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S5771 |
SulforaphaneSulforaphane 是一种天然存在的异硫氰酸盐,存在于十字花科蔬菜如西兰花、卷心菜、羽衣甘蓝。它是 Nrf2 的诱导物。Sulforaphane 也是 histone deacetylase (HDAC) 和 NF-κB 的抑制剂。Sulforaphane 可增加 heme oxygenase-1 (HO-1),并降低 reactive oxygen species (ROS) 的水平。Sulforaphane 诱导细胞周期停滞和凋亡。 |
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S3973 |
L-SelenoMethionineL-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense. |
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S4603 |
Gallic acidGallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid)是一种在多种食物和草药中发现的有机酸,是有效的抗氧化剂。 |
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S1631 |
Allopurinol SodiumAllopurinol Sodium 是一种黄嘌呤氧化酶抑制剂,IC50为7.82±0.12 μM。 |
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S9107 |
GlyciteinGlycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities. |
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S7171 |
Setanaxib (GKT137831)Setanaxib (GKT137831, GKT831) 是一种有效的双NADPH oxidase NOX1/NOX4抑制剂,Ki分别为110 nM和140 nM。GKT137831 处理可抑制 reactive oxygen species (ROS) 的产生。GKT137831 可一定程度上抑制铁死亡。 |
![]() ![]() (C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group). |
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S2369 |
TroxerutinTroxerutin 是一种黄酮醇类,是一种黄酮类化合物。 |
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S7873 |
Disodium (R)-2-HydroxyglutarateDisodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium)是一种竞争性α-ketoglutarate-dependent dioxygenases抑制剂,其 Ki值为10.87 ± 1.85 mM。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S1046 |
Vandetanib (ZD6474)Vandetanib (ZD6474) 是一种有效的 VEGFR2 抑制剂,在无细胞试验中IC50为40 nM。同时,也抑制VEGFR3和EGFR,IC50分别为110 nM 和500 nM。对PDGFRβ, Flt-1, Tie-2 和FGFR1作用效果不大,IC50为 1.1-3.6 μM, 对MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt 和 IGF-1R几乎没有作用效果,IC50>10 μM。Vandetanib (ZD6474) 可增加凋亡并通过提高 reactive oxygen species (ROS) 的水平来诱导自噬。 |
![]() ![]() Vandetanib reduced extracellular nitrite levels in endothelial cells. MS1 endothelial cells (ECs) were incubated with 1 mol/L of vandetanib or matched vehicle (dimethyl sulfoxide [DMSO]), 50 ng/mL of vascular endothelial growth factor (VEGF) or matched vehicle (PBS; 0.5 hours), and L-arginine and soluble N-ethylmaleamide sensitive factor attachment protein (SNAP) added (1.5 hours). Vandetanib lowered nitrite levels in MS1 Ecs (*P0.0003). VEGF was used a positive control and increased nitrite levels (**P0.02). These findings indicate that vandetanib lowered endothelial cell NO levels. |
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S2843 |
BI-D1870BI-D1870是一种ATP-竞争性S6 ribosome抑制剂,在无细胞试验中作用于RSK1/2/3/K4,IC50分别为31 nM/24 nM/18 nM/15 nM,作用于RSK比作用于MST2,GSK-3β,MARK3,CK1和Aurora B选择性高10到100倍。BI-D1870 显示除了抗癌的属性包括活性氧的生成、提高内质网应激反应和诱导自噬。 |
![]() ![]() Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.
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S4425New |
Rifamycin SRifamycin S 是一种quinone和抗 Gram-positive bacteria(包括MRSA) 的抗生素,是一种用于治疗肺结核和麻风病的临床药物。Rifamycin S 可产生 reactive oxygen species (ROS),并抑制微粒体脂质过氧化 microsomal lipid peroxidation。 |
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S3357New |
Elaidic acidElaidic acid 是一种主要的反式脂肪酸,可抑制细胞活力,并通过增强氧化应激 oxidative stress 来促进细胞的凋亡。Elaidic acid 可用作药物溶剂。 |
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S3238New |
ResibufogeninResibufogenin (Bufogenin, Recibufogenin) 是huachansu华蟾素中具有抗癌作用的成分,通过上调 receptor-interacting protein kinase 3 (RIP3) 和磷酸化 mixed lineage kinase domain-like protein 的Ser358位点来触发坏死病。Resibufogenin 可通过诱导 reactive oxygen species (ROS) 积累发挥细胞毒性作用。Resibufogenin 可诱导凋亡和 caspase-3 和 caspase-8 活性。Resibufogenin 增加 Bax/Bcl-2 表达,并抑制 cyclin D1、cyclin E、PI3K、p-AKT、p-GSK3β 和 β-catenin 的蛋白表达。 |
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S6871New |
Sodium oxamateSodium oxamate (SO, Aminooxoacetic acid, Oxamic acid)是一种 lactate dehydrogenase (LDH) 的抑制剂,可特异性地抑制LDH‑A。Sodium oxamate (SO) 通过下调 CDK1/cyclin B1 途径诱导G2/M细胞周期停滞,并通过增加线粒体内 ROS 的生成来促进凋亡。 |
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S9611New |
ABTL-0812ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) 可在肺鳞癌细胞系中通过诱导TRIB3的过表达和激活自噬来抑制 Akt/mTOR 轴。ABTL0812 还可诱导 AMPK 激活和 ROS 积累。 |
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S0770New |
CamalexinCamalexin, a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae), can induce reactive oxygen species (ROS) production. Camalexin has antibacterial, antifungal, antiproliferative and anticancer activities. |
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S5452 |
Sanguinarine chlorideSanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. |
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S7309 |
BAY 87-2243BAY 87-2243 是一种有效的选择性hypoxia-inducible factor-1 (HIF-1)抑制剂。BAY 87-2243 可抑制 mitochondrial complex I 的活性,从而触发依赖线粒体的ROS升高,导致细胞坏死和铁死亡ferroptosis。BAY 87-2243 具有抗肿瘤活性。Phase 1。 |
![]() ![]() Cells were plated at low density, treated with the indicated compounds and scored for resistance. Abbreviations: osimertinib (Osi), phenformin (Phen), metformin (Met), buformin (Buf), BAY 87-2243 (BAY), oligomycin (Oligo).
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S0056 |
(E/Z)-BCI(E/Z)-BCI (BCI, NSC 150117) 是一种 dual specific phosphatase 1/6 (DUSP1/DUSP6) 和 mitogen-activated protein kinase 的抑制剂,对细胞中DUSP6和DUSP1的EC50值分别为13.3 μM和8.0 μM。(E)-BCI 在H1299肺癌细胞中通过产生 reactive oxygen species (ROS) 和激活内在的线粒体途径来诱导凋亡。 |
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S5263 |
Pyrroloquinoline Quinone Disodium SaltPyrroloquinoline quinone (methoxatin disodium salt), an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions. |
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S2271 |
Berberine chlorideBerberine chloride (Natural Yellow 18 chloride)是异喹啉类生物碱的季铵盐。Berberine chloride 可激活 caspase 3 和 caspase 8,分裂 poly ADP-ribose polymerase (PARP) 和释放 cytochrome c。Berberine chloride 可降低 c-IAP1,Bcl-2 和 Bcl-XL 的表达。Berberine chloride 可通过 JNK 和 p38 MAPK 的持续磷酸化以及产生 ROS 来诱导凋亡。Berberine chloride 是一个 topoisomerase I 和 II 的双效抑制剂。Berberine chloride 也是一个潜在的自噬调节剂。 |
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S8615 |
Sodium dichloroacetate (DCA)Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA)是 pyruvate dehydrogenase kinase (PDK) 的特异性抑制剂,对PDK2和PDK4的IC50值分别为183和80 μM;可抑制 Na+-K+-2Cl- cotransporter 和线粒体钾离子通道轴。Sodium dichloroacetate 可增加活性氧的生成,引起癌细胞凋亡,并抑制肿瘤生长。 |
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S3607 |
SarsasapogeninSarsasapogenin (SAR, Parigenin)是一种甾体皂甙元,能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活,在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。 |
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S2348 |
Rotenone (Barbasco)Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) 是一种植物杀虫剂,是线粒体电子传递mitochondrial electron transport的抑制剂。Rotenone 可抑制 NADH/DB oxidoreductase 和 NADH oxidase,对应的IC50值分别为28.8 nM和5.1 nM。Rotenone 可通过增强线粒体活性氧的产生来诱导凋亡。 |
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S5584 |
CitronellolCitronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells. |
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S8661 |
CA3 (CIL56)CA3 (CIL56) 对YAP1/Tead转录活性具有有效的抑制作用,主要靶向高表达YAP1、具有癌症干细胞属性的、难治疗的食管腺癌细胞。CA3(CIL56)可诱导铁死亡和铁依赖的活性氧自由基。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S4419New |
EnsulizoleEnsulizole (PBSA) 是一种水溶性防晒成分,一种磺化的UV吸收剂,其特征是可强烈吸收UVB和部分吸收UVA。Ensulizole 可以通过紫外线或日光照射下 reactive oxygen species (ROS) 的生成来破坏DNA。 |
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S3301New |
CynarinCynarin (Cynarine) 是一种来自artichoke洋蓟的植物化学成分,具有多种药理特性,包括自由基清除、抗氧化剂、抗组氨酸和抗病毒活性。Cynarin 可阻断T细胞受体的 CD28 和抗原呈递细胞的 CD80 之间的相互作用。Cynarin 可触发 Nrf2 的核易位,恢复 glutathione (GSH) 和 reactive oxygen species (ROS) 的平衡,并抑制线粒体去极化。 |
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S5804 |
N-Acetylcysteine amideN-acetylcysteine amide是一种能穿透细胞膜的抗氧化剂,具有消炎活性,能够调节NF-κB的激活、HIF-1α和ROS。 |
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S2399 |
DihydromyricetinDihydromyricetin (Ampelopsin, Ampeloptin)是具有良好性能的天然抗氧化剂。 |
![]() ![]() ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation. |
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S4263 |
Efaproxiral SodiumEfaproxiral Sodium是一种人工合成的血红素异构修饰剂,用于乳腺癌脑转移瘤的治疗。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S3222New |
Raspberry ketone glucosideRaspberry ketone glucoside (RKG) 是来源于树莓果实的天然产物,是一种抗氧化剂antioxidant,对黑色素 melanin 的合成具有抑制作用。 |
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S9687New |
H2DCFDAH2DCFDA (DCFH-DA, 2',7'-Dichlorodihydrofluorescein diacetate) 是一种可渗透细胞的探针,可用于检测细胞内 reactive oxygen species (ROS) 的产生。 |
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S2605 |
IdebenoneIdebenone (CV-2619) 是一种辅酶Q10(CoQ10)的合成类似物,是一种大脑兴奋剂。 |
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S2062 |
TioproninTiopronin是美国食品和药物管理局(FDA)批准的用于治疗治疗胱氨酸尿症的药物,通过控制胱氨酸沉淀和排泄速率。 |
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S4580 |
HydroquinoneHydroquinone (Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ)是黑色素合成抑制剂。Hydroquinone的生理效应通过其褪色活性发挥。它还具有抗氧化特性,在多个器官中,尤其是肾脏中产生毒性作用。 |
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S4970 |
NerolNerol (Cis-Geraniol, Neryl alcohol)是存在于多种香精油如柠檬草和槐花中的单萜化合物。 |
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S5314 |
HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone)HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone), which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent. |
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S3838 |
Carnosic acidCarnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries. |
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S3840 |
Baohuoside IBaohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway. |
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S9021 |
(20R)Ginsenoside Rg3(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite. |
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S9034 |
Isochlorogenic acid CIsochlorogenic acid C (3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid), which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71. |
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S2332 |
NeohesperidinNeohesperidin (NSC 31048) 是一种抗氧化剂,在1,1-diphenyl-2-picryldydrazyl(DPPH)自由基清除测定中,IC50为22.31 μg/ml。 |
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S3885 |
PyrogallolPyrogallol (1,2,3-trihydroxybenzene), an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer. |
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S4511 |
6-Benzylaminopurine6-Benzylaminopurine是第一代合成的细胞分裂素,可调节植物的抗氧化系统的活性。它对植物的生长和发育有一定促进作用。 |
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S7551 |
PiperlonguminePiperlongumine (PPLGM, Piplartine),存在于胡椒科植物荜茇中的一种天然生物碱,能够增加reactive oxygen species (ROS)水平,并选择性杀死癌细胞。它还是TrxR1的直接抑制剂,对胃癌具有抑制活性;一种新型的CRM1抑制剂;在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。 |
![]() ![]() a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. *P < 0.05; **P < 0.01; ***P < 0.001.
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S7867 |
OleuropeinOleuropein 是一种从橄榄叶中分离出的抗氧化多酚。Oleuropein 具有抗氧化、抗炎和抗动脉粥样硬化的作用,并在体外抑制脂肪细胞的分化。Oleuropein 抑制 PPARγ 活性。Oleuropein 通过直接抑制PPARγ转录活性发挥抗脂肪形成作用。Oleuropein 还可抑制aromatase。Oleuropein 可诱导凋亡。Phase 2。 |
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S2363 |
TangeretinTangeretin (Tangeritin)是一种柑橘类黄酮。 |
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S4722 |
(+)-Catechin(+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) 是抗氧化类黄酮,主要以(+)-catechin和(-)-epicatechin的形式存在于木本植物中。 |
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S4723 |
(-)Epicatechin(−)Epicatechin (L-Epicatechin, (-)-Epicatechol)是一种类黄酮,在可可、绿茶、红酒中常见。具有强的抗氧化、胰岛素类似作用,能改善心脏健康。 |