ROS

抑制剂选择性比较
溶解性比较

目录号	产品目录	溶解度(25°C)
目录号	产品目录	水	DMSO	酒精
S1547	Febuxostat	<1 mg/mL	63 mg/mL	<1 mg/mL
S1623	Acetylcysteine	33 mg/mL	33 mg/mL	33 mg/mL
S1630	Allopurinol	4 mg/mL	27 mg/mL	3 mg/mL
S3973	L-SelenoMethionine	39 mg/mL	<1 mg/mL	-1 mg/mL
S3616	Asiaticoside	<1 mg/mL	100 mg/mL	<1 mg/mL
S3631	(S)-Methylisothiourea sulfate	27 mg/mL	<1 mg/mL	<1 mg/mL
S4603	Gallic acid	7 mg/mL	34 mg/mL	34 mg/mL
S1631	Allopurinol Sodium	32 mg/mL	32 mg/mL	2 mg/mL
S4074	Sodium Nitrite	13 mg/mL	13 mg/mL	<1 mg/mL
S5263	Pyrroloquinoline Quinone Disodium Salt	-1 mg/mL	74 mg/mL	-1 mg/mL
S3607	Sarsasapogenin	<1 mg/mL	<1 mg/mL	5 mg/mL
S2399	Dihydromyricetin	<1 mg/mL	64 mg/mL	64 mg/mL
S2605	Idebenone	<1 mg/mL	68 mg/mL	68 mg/mL
S2062	Tiopronin	32 mg/mL	32 mg/mL	32 mg/mL
S9021	(20R)Ginsenoside Rg3		60.78 mg/mL
S9034	Isochlorogenic acid C		100 mg/mL
S3885	Pyrogallol	-1 mg/mL	25 mg/mL	-1 mg/mL
S3838	Carnosic acid	-1 mg/mL	66 mg/mL	-1 mg/mL
S3840	Baohuoside I	-1 mg/mL	100 mg/mL	-1 mg/mL
S4580	Hydroquinone	22 mg/mL	22 mg/mL	22 mg/mL
S3632	Trichloroisocyanuric acid	20 mg/mL	46 mg/mL	2 mg/mL
S2332	Neohesperidin	<1 mg/mL	122 mg/mL	<1 mg/mL
S4511	6-Benzylaminopurine	<1 mg/mL	45 mg/mL	<1 mg/mL
S7551	Piperlongumine	<1 mg/mL	16 mg/mL	6 mg/mL
S7867	Oleuropein	100 mg/mL	100 mg/mL	100 mg/mL
S2363	Tangeretin	<1 mg/mL	8 mg/mL	<1 mg/mL
S4722	(+)-Catechin	58 mg/mL	58 mg/mL	58 mg/mL
S4723	(-)Epicatechin	<1 mg/mL	58 mg/mL	<1 mg/mL

ROS抑制剂（29）
新ROS产品

产品目录	产品描述	文献引用	实验数据
S1547	Febuxostat Febuxostat 是一种非嘌呤，选择性黄嘌呤氧化酶抑制剂，IC50为114-210 nM。	Br J Pharmacol, 2016, 173(14):2290-302 Free Radic Biol Med, 2015, 10.1016/j.freeradbiomed.2015.02.016	NOX activity was measured as lucigenin-dependent chemiluminescence of superoxide. Incubation with febuxostat increased superoxide generation in nonactivated macrophages, but did not significantly influence superoxide formation in LPS-activated macrophages. Simultaneous treatment with febuxostat abolished the effect of nitrite during activation with LPS. Data are means±SEM (n=10-12). *, p<0.05. LPS, lipopolysaccharide (10 ng/ml); NO2, sodium nitrite (10 μM); febuxostat, xanthine oxidase inhibitor (30 nM).
S1623	Acetylcysteine Acetylcysteine(N-acetyl-l-cysteine)是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可处理扑热息痛(对乙酰氨基酚)过量。	Cell, 2018, 175(2):442-457 Biochem Pharmacol, 2017, 146:224-232 J Cell Physiol, 2015, 230(9):2281-98
S1630	Allopurinol Allopurinol 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。	Nature, 2018, 560(7718):372-376
S9107^New	Glycitein Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.
S3973^New	L-SelenoMethionine L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.
S3616	Asiaticoside Asiaticoside是Centella asiatica（积雪草）中的主要活性成分，通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。
S3631	(S)-Methylisothiourea sulfate (S)-Methylisothiourea sulfate是iNOS的抑制剂。
S4603	Gallic acid Gallic acid是一种在多种食物和草药中发现的有机酸，是有效的抗氧化剂。
S1631	Allopurinol Sodium Allopurinol Sodium 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。
S4074	Sodium Nitrite Sodium Nitrite是一种绿过氧物酶抑制剂，IC50为 1.3 μM。
S5263^New	Pyrroloquinoline Quinone Disodium Salt Pyrroloquinoline quinone, an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions.
S3607	Sarsasapogenin Sarsasapogenin (SAR)是一种甾体皂甙元，能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活，在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。
S2399	Dihydromyricetin Dihydromyricetin 是具有良好性能的天然抗氧化剂。	Food Chem Toxicol, 2012, 50(7):2508-14 Oncotarget, 2016, 10.18632/oncotarget.10836	A. Cal27 cells transfected with GFP-LC3 plasmid were treated with different concentration of DHM for 24 h. The formation of GFP-LC3 puncta were examined using immunofluorescence and quantified. Scale bar 50 μm.
S2605	Idebenone Idebenone是一种辅酶Q10（CoQ10）的合成类似物，是一种大脑兴奋剂。
S2062	Tiopronin Tiopronin是美国食品和药物管理局（FDA）批准的用于治疗治疗胱氨酸尿症的药物，通过控制胱氨酸沉淀和排泄速率。
S9021^New	(20R)Ginsenoside Rg3 (20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.
S9034^New	Isochlorogenic acid C Isochlorogenic acid C, which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.
S3885^New	Pyrogallol Pyrogallol, an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.
S3838^New	Carnosic acid Carnosic acid is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.
S3840^New	Baohuoside I Baohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.
S4580	Hydroquinone Hydroquinone是黑色素合成抑制剂。Hydroquinone的生理效应通过其褪色活性发挥。它还具有抗氧化特性，在多个器官中，尤其是肾脏中产生毒性作用。
S3632	Trichloroisocyanuric acid TrichloroisTrichloroisocyanuric acid (TCCA)是一种安全有效的试剂，作用于氯化作用和氧化反应。
S2332	Neohesperidin Neohesperidin 是一种抗氧化剂，在1,1-diphenyl-2-picryldydrazyl（DPPH）自由基清除测定中，IC50为22.31 μg/ml。
S4511	6-Benzylaminopurine 6-Benzylaminopurine是第一代合成的细胞分裂素，可调节植物的抗氧化系统的活性。它对植物的生长和发育有一定促进作用。
S7551	Piperlongumine Piperlongumine，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。	Oncotarget, 2016, 7(26):40531-40545 Oncotarget, 2016, 10.18632/oncotarget.10921 Oncotarget, 2016, 7(35):56933-56943	a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. P < 0.05; P < 0.01; **P < 0.001.
S7867	Oleuropein Oleuropein是一种从橄榄叶中分离出的抗氧化多酚。Phase 2。
S2363	Tangeretin Tangeretin 是一种柑橘类黄酮。
S4722	(+)-Catechin Cianidanol是抗氧化类黄酮，主要以(+)-catechin和(-)-epicatechin的形式存在于木本植物中。
S4723	(-)Epicatechin (−)Epicatechin是一种类黄酮，在可可、绿茶、红酒中常见。具有强的抗氧化、胰岛素类似作用，能改善心脏健康。

研究领域

产品类型

ROS

Febuxostat

Acetylcysteine

Allopurinol

Glycitein

L-SelenoMethionine

Asiaticoside

(S)-Methylisothiourea sulfate

Gallic acid

Allopurinol Sodium

Sodium Nitrite

Pyrroloquinoline Quinone Disodium Salt

Sarsasapogenin

Dihydromyricetin

Idebenone

Tiopronin

(20R)Ginsenoside Rg3

Isochlorogenic acid C

Pyrogallol

Carnosic acid

Baohuoside I

Hydroquinone

Trichloroisocyanuric acid

Neohesperidin

6-Benzylaminopurine

Piperlongumine

Oleuropein

Tangeretin

(+)-Catechin

(-)Epicatechin