ROS

抑制剂选择性比较

ROS产品

所有产品(69) ROS抑制剂(26) ROS激活剂(18) ROS调节剂(5)

目录号	产品描述	文献引用	实验数据
S1547	Febuxostat Febuxostat (TMX 67, TEI-6720) 是一种非嘌呤，选择性黄嘌呤氧化酶抑制剂，IC50为114-210 nM。	J Proteome Res, 2021, 20(6):3134-3149 Viruses, 2020, 12(10)E1067 Redox Biol, 2018, 16:157-168	NOX activity was measured as lucigenin-dependent chemiluminescence of superoxide. Incubation with febuxostat increased superoxide generation in nonactivated macrophages, but did not significantly influence superoxide formation in LPS-activated macrophages. Simultaneous treatment with febuxostat abolished the effect of nitrite during activation with LPS. Data are means±SEM (n=10-12). *, p<0.05. LPS, lipopolysaccharide (10 ng/ml); NO2, sodium nitrite (10 μM); febuxostat, xanthine oxidase inhibitor (30 nM).
S1623	Acetylcysteine (N-acetylcysteine) Acetylcysteine (N-acetyl-l-cysteine, NAC)是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用。	EMBO Mol Med, 2022, 14(2):e14903 J Exp Clin Cancer Res, 2022, 41(1):41 J Nanobiotechnology, 2022, 20(1):78	(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
S1630	Allopurinol Allopurinol 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。	Hum Cell, 2022, 10.1007/s13577-022-00671-y J Reprod Immunol, 2021, 149:103457 J Proteome Res, 2021, 20(6):3134-3149
S3616	Asiaticoside Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol) 是Centella asiatica（积雪草）中的主要活性成分，通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。	Med Sci Monit, 2020, 26:e924435
S3631	(S)-Methylisothiourea sulfate (S)-Methylisothiourea sulfate是iNOS的抑制剂。	Mol Immunol, 2020, 117:189-200
S4017	Allylthiourea Allylthiourea是一种代谢抑制剂,选择性抑制ammonia oxidation(氨氧化)。
S6281	Sodium Thiocyanate Sodium Thiocyanate (NaSCN, Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate)是硫氰酸盐阴离子的主要来源之一，被用作合成药物和其他专用化学品的前体。Sodium Thiocyanate (NaSCN) 降低 IL-6，而增加 IL-10 的表达水平。Sodium Thiocyanate 还可以降低 ROS 水平。
S3590	Triolein Triolein 是一种 metalloproteinase-1 (MMP-1) 的抑制剂，可降低辐射角化细胞中 IL-6 和 ROS 的表达。
S4853	Ecabet sodium Ecabet sodium (TA-2711, TA-2711E) is a widely employed mucoprotective agent for the treatment of gastric ulcers.
S8639	Diphenyleneiodonium chloride (DPI) Diphenyleneiodonium chloride (DPI)是 NADPH oxidase 的抑制剂，也是有效的、不可逆的 iNOS/eNOS 抑制剂。Diphenyleneiodonium chloride (DPI) 还起到 TRPA1 激活剂的作用，并能选择性地抑制细胞内的活性氧(ROS)。	Nat Biotechnol, 2022, 10.1038/s41587-021-01169-y J Nanobiotechnology, 2022, 20(1):65 Cell Chem Biol, 2022, S2451-9456(22)00127-1
S0947	Cafestol Cafestol是从咖啡豆中提取的天然二萜。Cafestol 诱导细胞凋亡并调节多种炎症介质以减轻炎症。Cafestol 抑制 PI3K/Akt 通路。Cafestol 还可以减少白血病细胞系 HL60 中 ROS 的产生。
S3816	Dehydroevodiamine Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.
S5771	Sulforaphane Sulforaphane 是一种天然存在的异硫氰酸盐，存在于十字花科蔬菜如西兰花、卷心菜、羽衣甘蓝。它是 Nrf2 的诱导物。Sulforaphane 也是 histone deacetylase (HDAC) 和 NF-κB 的抑制剂。Sulforaphane 可增加 heme oxygenase-1 (HO-1)，并降低 reactive oxygen species (ROS) 的水平。Sulforaphane 诱导细胞周期停滞和凋亡。	Elife, 2022, 11e67368 Cell Death Discov, 2021, 7(1):375 Cell Commun Signal, 2021, 19(1):35
S3973	L-SelenoMethionine L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.
S4603	Gallic acid Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid)是一种在多种食物和草药中发现的有机酸，是有效的抗氧化剂。	J Nutr Biochem, 2015, 26(11):1379-84
S1631	Allopurinol Sodium Allopurinol Sodium 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。	J Reprod Immunol, 2021, 149:103457 Nat Commun, 2020, 11(1):481 Reproduction, 2020, 159(1):73-80
S6920	SEA0400 SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂，可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收，对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERK 和 p38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。
S4074	Sodium Nitrite Sodium Nitrite是一种绿过氧物酶抑制剂，IC50为 1.3 μM。
S8974	GSK2795039 GSK2795039 是 NADPH oxidase 2 (NOX2) 的抑制剂，对于NOX2介导的HRP/Amplex Red的激活的pIC50值为6.57。GSK2795039 可抑制活性氧reactive oxygen species (ROS)的产生，NADPH的消耗并减少细胞凋亡。
S8978	Mitoquinone (MitoQ10) mesylate Mitoquinone mesylate (MitoQ, MitoQ10, Mitoubiquinone) 是一种基于TPP的线粒体mitochondria靶向抗氧化剂，可阻断H₂O₂诱导的细胞内 ROS 反应并防止氧化损伤。该产品呈胶状。	J Exp Clin Cancer Res, 2022, 41(1):83 Aging Cell, 2022, 21(3):e13574 Drug Dev Res, 2022, 10.1002/ddr.21911
S9107	Glycitein Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.
S7171	Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) 是一种有效的双NADPH oxidase NOX1/NOX4抑制剂，Ki分别为110 nM和140 nM。GKT137831 处理可抑制 reactive oxygen species (ROS) 的产生。GKT137831 可一定程度上抑制铁死亡。	Cell Chem Biol, 2022, S2451-9456(22)00127-1 Antioxidants (Basel), 2022, 11(3)513 Food Chem Toxicol, 2022, 163:112966	(C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group).
S3578	Pyrroloquinoline quinone Pyrroloquinoline quinone (PQQ, Methoxatin) 是一种天然的抗氧化剂，具有抗氧化和抗衰老的作用。Pyrroloquinoline quinone 可预防雌激素缺乏引起的骨质疏松症。
S3205	Perillaldehyde Perillaldehyde (Perilladehyde, Perillal, PAE, PA) 是紫苏 Perilla frutescens（一种传统的抗氧化剂）的主要成分，可抑制BaP诱导的 AHR 的活化和 ROS 的产生，抑制 BaP/AHR 介导的 CCL2 chemokine 的释放，并激活 NRF2/HO1 抗氧化剂途径。
S2369	Troxerutin Troxerutin 是一种黄酮醇类，是一种黄酮类化合物。	Food Funct, 2019, 10(8):5059-5069
S7873	Disodium (R)-2-Hydroxyglutarate Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium)是一种竞争性α-ketoglutarate-dependent dioxygenases抑制剂，其 K_i值为10.87 ± 1.85 mM。	Cell Mol Immunol, 2022, 10.1038/s41423-022-00842-9 Mol Ther, 2022, S1525-0016(22)00007-7 Cell Metab, 2021, 33(1):110-127.e5
S1046	Vandetanib (ZD6474) Vandetanib (ZD6474) 是一种有效的 VEGFR2 抑制剂，在无细胞试验中IC50为40 nM。同时，也抑制VEGFR3和EGFR，IC50分别为110 nM 和500 nM。对PDGFRβ, Flt-1, Tie-2 和FGFR1作用效果不大，IC50为 1.1-3.6 μM, 对MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt 和 IGF-1R几乎没有作用效果，IC50>10 μM。Vandetanib (ZD6474) 可增加凋亡并通过提高 reactive oxygen species (ROS) 的水平来诱导自噬。	Cancer Res, 2022, canres.1397.2021 Hum Cell, 2022, 10.1007/s13577-022-00671-y Cell Rep Med, 2022, 3(1):100492	Vandetanib increases membrane localization of endothelial NO synthase (eNOS). MS1 endothelial cells (ECs) were incubated with 1 μmol/L of vandetanib or matched vehicle (dimethyl sulfoxide [DMSO]). Western blotting analysis showed that vandetanib increases membrane localization of eNOS compared with control (*P<0.04; n=4 per group, studies done in triplicate). These findings show that vandetanib increased the membrane localization of eNOS compared with control.
S2843	BI-D1870 BI-D1870是一种ATP-竞争性S6 ribosome抑制剂，在无细胞试验中作用于RSK1/2/3/K4，IC50分别为31 nM/24 nM/18 nM/15 nM，作用于RSK比作用于MST2，GSK-3β，MARK3，CK1和Aurora B选择性高10到100倍。BI-D1870 显示除了抗癌的属性包括活性氧的生成、提高内质网应激反应和诱导自噬。	Cancer Sci, 2022, 113(1):132-144 EMBO J, 2021, 40(7):e106106 Cell Rep, 2021, 37(12):110137	Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.
S5452	Sanguinarine chloride Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor.	Front Pharmacol, 2021, 12:638215
S3238	Resibufogenin Resibufogenin (Bufogenin, Recibufogenin) 是huachansu华蟾素中具有抗癌作用的成分，通过上调 receptor-interacting protein kinase 3 (RIP3) 和磷酸化 mixed lineage kinase domain-like protein 的Ser358位点来触发坏死病。Resibufogenin 可通过诱导 reactive oxygen species (ROS) 积累发挥细胞毒性作用。Resibufogenin 可诱导凋亡和 caspase-3 和 caspase-8 活性。Resibufogenin 增加 Bax/Bcl-2 表达，并抑制 cyclin D1、cyclin E、PI3K、p-AKT、p-GSK3β 和 β-catenin 的蛋白表达。
S7309	BAY 87-2243 BAY 87-2243 是一种有效的选择性hypoxia-inducible factor-1 (HIF-1)抑制剂。BAY 87-2243 可抑制 mitochondrial complex I 的活性，从而触发依赖线粒体的ROS升高，导致细胞坏死和铁死亡ferroptosis。BAY 87-2243 具有抗肿瘤活性。Phase 1。	J Immunother Cancer, 2022, 10(3)e004414 Theranostics, 2021, 11(1):209-221 Cancer Lett, 2021, 529:19-36	Cells were plated at low density, treated with the indicated compounds and scored for resistance. Abbreviations: osimertinib (Osi), phenformin (Phen), metformin (Met), buformin (Buf), BAY 87-2243 (BAY), oligomycin (Oligo).
S0056	(E/Z)-BCI (E/Z)-BCI (BCI, NSC 150117) 是一种 dual specific phosphatase 1/6 (DUSP1/DUSP6) 和 mitogen-activated protein kinase 的抑制剂，对细胞中DUSP6和DUSP1的EC50值分别为13.3 μM和8.0 μM。(E)-BCI 在H1299肺癌细胞中通过产生 reactive oxygen species (ROS) 和激活内在的线粒体途径来诱导凋亡。
S0770	Camalexin Camalexin, a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae), can induce reactive oxygen species (ROS) production. Camalexin has antibacterial, antifungal, antiproliferative and anticancer activities.
S5263	Pyrroloquinoline Quinone Disodium Salt Pyrroloquinoline quinone (methoxatin disodium salt), an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions.
S6871	Sodium oxamate Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid)是一种 lactate dehydrogenase (LDH) 的抑制剂，可特异性地抑制LDH‑A。Sodium oxamate (SO) 通过下调 CDK1/cyclin B1 途径诱导G2/M细胞周期停滞，并通过增加线粒体内 ROS 的生成来促进凋亡。	Aging (Albany NY), 2021, 13(24):25920-25930 Int J Biol Sci, 2021, 17(11):2756-2769
S2271	Berberine chloride (NSC 646666) Berberine chloride (NSC 646666, Natural Yellow 18)是异喹啉类生物碱的季铵盐。Berberine chloride 可激活 caspase 3 和 caspase 8，分裂 poly ADP-ribose polymerase (PARP) 和释放 cytochrome c。Berberine chloride 可降低 c-IAP1，Bcl-2 和 Bcl-XL 的表达。Berberine chloride 可通过 JNK 和 p38 MAPK 的持续磷酸化以及产生 ROS 来诱导凋亡。Berberine chloride 是一个 topoisomerase I 和 II 的双效抑制剂。Berberine chloride 也是一个潜在的自噬调节剂。	Front Pharmacol, 2021, 12:632201 Molecules, 2021, 26(5)1210 Biology (Basel), 2021, 10(3)250
S8615	Sodium dichloroacetate (DCA) Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA)是 pyruvate dehydrogenase kinase (PDK) 的特异性抑制剂，对PDK2和PDK4的IC50值分别为183和80 μM；可抑制 Na⁺-K⁺-2Cl^- cotransporter 和线粒体钾离子通道轴。Sodium dichloroacetate 可增加活性氧的生成，引起癌细胞凋亡，并抑制肿瘤生长。	Nat Commun, 2022, 13(1):1417 Mol Oncol, 2022, 16(1):219-249 J Exp Clin Cancer Res, 2021, 40(1):87
S3357	Elaidic acid Elaidic acid 是一种主要的反式脂肪酸，可抑制细胞活力，并通过增强氧化应激 oxidative stress 来促进细胞的凋亡。Elaidic acid 可用作药物溶剂。
S3607	Sarsasapogenin Sarsasapogenin (SAR, Parigenin)是一种甾体皂甙元，能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活，在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。
S9611	ABTL-0812 ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) 可在肺鳞癌细胞系中通过诱导TRIB3的过表达和激活自噬来抑制 Akt/mTOR 轴。ABTL0812 还可诱导 AMPK 激活和 ROS 积累。
S2348	Rotenone (Barbasco) Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) 是一种植物杀虫剂，是线粒体电子传递mitochondrial electron transport的抑制剂。Rotenone 可抑制 NADH/DB oxidoreductase 和 NADH oxidase，对应的IC50值分别为28.8 nM和5.1 nM。Rotenone 可通过增强线粒体活性氧的产生来诱导凋亡。	Sci Signal, 2022, 15(721):eabi9983 Food Funct, 2022, 10.1039/d1fo03909a Nature, 2021, 10.1038/s41586-021-04049-2
S5584	Citronellol Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells.
S4425	Rifamycin S Rifamycin S 是一种quinone和抗 Gram-positive bacteria(包括MRSA) 的抗生素，是一种用于治疗肺结核和麻风病的临床药物。Rifamycin S 可产生 reactive oxygen species (ROS)，并抑制微粒体脂质过氧化 microsomal lipid peroxidation。
S8661	CA3 (CIL56) CA3 (CIL56) 对YAP1/Tead转录活性具有有效的抑制作用，主要靶向高表达YAP1、具有癌症干细胞属性的、难治疗的食管腺癌细胞。CA3(CIL56)可诱导铁死亡和铁依赖的活性氧自由基。	Cell Rep, 2022, 38(7):110390 Sci Rep, 2022, 12(1):45 Cancers (Basel), 2021, 13(21)5474
S3301	Cynarin Cynarin (Cynarine) 是一种来自artichoke洋蓟的植物化学成分，具有多种药理特性，包括自由基清除、抗氧化剂、抗组氨酸和抗病毒活性。Cynarin 可阻断T细胞受体的 CD28 和抗原呈递细胞的 CD80 之间的相互作用。Cynarin 可触发 Nrf2 的核易位，恢复 glutathione (GSH) 和 reactive oxygen species (ROS) 的平衡，并抑制线粒体去极化。
S5804	N-Acetylcysteine amide N-acetylcysteine amide是一种能穿透细胞膜的抗氧化剂，具有消炎活性，能够调节NF-κB的激活、HIF-1α和ROS。	Nat Commun, 2021, 12(1):647 Int J Biochem Cell Biol, 2020, 121:105703 Pancreatology, 2019, 19(2):258-265
S2399	Dihydromyricetin Dihydromyricetin (Ampelopsin, Ampeloptin)是具有良好性能的天然抗氧化剂。	Molecules, 2021, 26(5)1210 Cell Signal, 2020, 65:109431 J Med Virol, 2019, 91(8):1440-1447	ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation.
S4263	Efaproxiral Sodium Efaproxiral Sodium是一种人工合成的血红素异构修饰剂，用于乳腺癌脑转移瘤的治疗。
S4419	Ensulizole Ensulizole (PBSA) 是一种水溶性防晒成分，一种磺化的UV吸收剂，其特征是可强烈吸收UVB和部分吸收UVA。Ensulizole 可以通过紫外线或日光照射下 reactive oxygen species (ROS) 的生成来破坏DNA。
S2605	Idebenone Idebenone (CV-2619) 是一种辅酶Q10（CoQ10）的合成类似物，是一种大脑兴奋剂。	Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00196-X
S2062	Tiopronin Tiopronin是美国食品和药物管理局（FDA）批准的用于治疗治疗胱氨酸尿症的药物，通过控制胱氨酸沉淀和排泄速率。
S3222	Raspberry ketone glucoside Raspberry ketone glucoside (RKG) 是来源于树莓果实的天然产物，是一种抗氧化剂antioxidant，对黑色素 melanin 的合成具有抑制作用。
S4580	Hydroquinone Hydroquinone (Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ)是黑色素合成抑制剂。Hydroquinone的生理效应通过其褪色活性发挥。它还具有抗氧化特性，在多个器官中，尤其是肾脏中产生毒性作用。	Theranostics, 2022, 12(5):2063-2079 Neurotox Res, 2020, 2
S3632	Trichloroisocyanuric acid TrichloroisTrichloroisocyanuric acid (TCCA)是一种安全有效的试剂，作用于氯化作用和氧化反应。
S4970	Nerol Nerol (Cis-Geraniol, Neryl alcohol)是存在于多种香精油如柠檬草和槐花中的单萜化合物。
S5314	HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone) HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone), which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent.
S3838	Carnosic acid Carnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.	Am J Cancer Res, 2020, 1;10(5):1442-1454 J Reprod Dev, 2020, 10.1262/jrd.2020-086
S3840	Baohuoside I Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.
S9021	(20R)Ginsenoside Rg3 (20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.	Bioorg Chem, 2021, 111:104844 J Agric Food Chem, 2021, 69(21):6073-6086 Environ Toxicol, 2020, 10.1002/tox.22899
S9034	Isochlorogenic acid C Isochlorogenic acid C (3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid), which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.
S2332	Neohesperidin Neohesperidin (NSC 31048) 是一种抗氧化剂，在1,1-diphenyl-2-picryldydrazyl（DPPH）自由基清除测定中，IC50为22.31 μg/ml。	Curr Opin Colloid Interface Sci, 2021, 101461 Eur J Pharmacol, 2019, 864:172712 J Med Virol, 2019, 91(8):1440-1447
S3885	Pyrogallol Pyrogallol (1,2,3-trihydroxybenzene), an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.	Parasit Vectors, 2020, 13(1):449
S4511	6-Benzylaminopurine 6-Benzylaminopurine是第一代合成的细胞分裂素，可调节植物的抗氧化系统的活性。它对植物的生长和发育有一定促进作用。
S7551	Piperlongumine Piperlongumine (PPLGM, Piplartine)，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。	Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Nat Commun, 2022, 13(1):107 SLAS Discov, 2021, 24725552211020678	a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. P < 0.05; P < 0.01; **P < 0.001.
S9687	H2DCFDA H2DCFDA (DCFH-DA, 2',7'-Dichlorodihydrofluorescein diacetate) 是一种可渗透细胞的探针，可用于检测细胞内 reactive oxygen species (ROS) 的产生。
S7867	Oleuropein Oleuropein 是一种从橄榄叶中分离出的抗氧化多酚。Oleuropein 具有抗氧化、抗炎和抗动脉粥样硬化的作用，并在体外抑制脂肪细胞的分化。Oleuropein 抑制 PPARγ 活性。Oleuropein 通过直接抑制PPARγ转录活性发挥抗脂肪形成作用。Oleuropein 还可抑制aromatase。Oleuropein 可诱导凋亡。Phase 2。	J Med Virol, 2019, 91(8):1440-1447
S2363	Tangeretin Tangeretin (Tangeritin)是一种柑橘类黄酮。	Evid Based Complement Alternat Med, 2022, 2022:6422500 Int J Mol Sci, 2020, 21(14):5025 Cancer Manag Res, 2019, 11:5231-5242
S4722	(+)-Catechin (+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) 是抗氧化类黄酮，主要以(+)-catechin和(-)-epicatechin的形式存在于木本植物中。	J Steroid Biochem Mol Biol, 2021, 211:105906
S4723	(-)Epicatechin (−)Epicatechin (L-Epicatechin, (-)-Epicatechol)是一种类黄酮，在可可、绿茶、红酒中常见。具有强的抗氧化、胰岛素类似作用，能改善心脏健康。	J Steroid Biochem Mol Biol, 2021, 211:105906 G3 (Bethesda), 2020, 4;10(5):1585-1597

目录号	产品描述	文献引用	实验数据
S1547	Febuxostat Febuxostat (TMX 67, TEI-6720) 是一种非嘌呤，选择性黄嘌呤氧化酶抑制剂，IC50为114-210 nM。	J Proteome Res,2021, 20(6):3134-3149 Viruses,2020, 12(10)E1067 Redox Biol,2018, 16:157-168	NOX activity was measured as lucigenin-dependent chemiluminescence of superoxide. Incubation with febuxostat increased superoxide generation in nonactivated macrophages, but did not significantly influence superoxide formation in LPS-activated macrophages. Simultaneous treatment with febuxostat abolished the effect of nitrite during activation with LPS. Data are means±SEM (n=10-12). *, p<0.05. LPS, lipopolysaccharide (10 ng/ml); NO2, sodium nitrite (10 μM); febuxostat, xanthine oxidase inhibitor (30 nM).
S1623	Acetylcysteine (N-acetylcysteine) Acetylcysteine (N-acetyl-l-cysteine, NAC)是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用。	EMBO Mol Med,2022, 14(2):e14903 J Exp Clin Cancer Res,2022, 41(1):41 J Nanobiotechnology,2022, 20(1):78	(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
S1630	Allopurinol Allopurinol 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。	Hum Cell,2022, 10.1007/s13577-022-00671-y J Reprod Immunol,2021, 149:103457 J Proteome Res,2021, 20(6):3134-3149
S3616	Asiaticoside Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol) 是Centella asiatica（积雪草）中的主要活性成分，通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。	Med Sci Monit,2020, 26:e924435
S3631	(S)-Methylisothiourea sulfate (S)-Methylisothiourea sulfate是iNOS的抑制剂。	Mol Immunol,2020, 117:189-200
S4017	Allylthiourea Allylthiourea是一种代谢抑制剂,选择性抑制ammonia oxidation(氨氧化)。
S6281	Sodium Thiocyanate Sodium Thiocyanate (NaSCN, Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate)是硫氰酸盐阴离子的主要来源之一，被用作合成药物和其他专用化学品的前体。Sodium Thiocyanate (NaSCN) 降低 IL-6，而增加 IL-10 的表达水平。Sodium Thiocyanate 还可以降低 ROS 水平。
S3590	Triolein Triolein 是一种 metalloproteinase-1 (MMP-1) 的抑制剂，可降低辐射角化细胞中 IL-6 和 ROS 的表达。
S4853	Ecabet sodium Ecabet sodium (TA-2711, TA-2711E) is a widely employed mucoprotective agent for the treatment of gastric ulcers.
S8639	Diphenyleneiodonium chloride (DPI) Diphenyleneiodonium chloride (DPI)是 NADPH oxidase 的抑制剂，也是有效的、不可逆的 iNOS/eNOS 抑制剂。Diphenyleneiodonium chloride (DPI) 还起到 TRPA1 激活剂的作用，并能选择性地抑制细胞内的活性氧(ROS)。	Nat Biotechnol,2022, 10.1038/s41587-021-01169-y J Nanobiotechnology,2022, 20(1):65 Cell Chem Biol,2022, S2451-9456(22)00127-1
S0947	Cafestol Cafestol是从咖啡豆中提取的天然二萜。Cafestol 诱导细胞凋亡并调节多种炎症介质以减轻炎症。Cafestol 抑制 PI3K/Akt 通路。Cafestol 还可以减少白血病细胞系 HL60 中 ROS 的产生。
S3816	Dehydroevodiamine Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.
S5771	Sulforaphane Sulforaphane 是一种天然存在的异硫氰酸盐，存在于十字花科蔬菜如西兰花、卷心菜、羽衣甘蓝。它是 Nrf2 的诱导物。Sulforaphane 也是 histone deacetylase (HDAC) 和 NF-κB 的抑制剂。Sulforaphane 可增加 heme oxygenase-1 (HO-1)，并降低 reactive oxygen species (ROS) 的水平。Sulforaphane 诱导细胞周期停滞和凋亡。	Elife,2022, 11e67368 Cell Death Discov,2021, 7(1):375 Cell Commun Signal,2021, 19(1):35
S3973	L-SelenoMethionine L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.
S4603	Gallic acid Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid)是一种在多种食物和草药中发现的有机酸，是有效的抗氧化剂。	J Nutr Biochem,2015, 26(11):1379-84
S1631	Allopurinol Sodium Allopurinol Sodium 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。	J Reprod Immunol,2021, 149:103457 Nat Commun,2020, 11(1):481 Reproduction,2020, 159(1):73-80
S6920	SEA0400 SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂，可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收，对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERK 和 p38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。
S4074	Sodium Nitrite Sodium Nitrite是一种绿过氧物酶抑制剂，IC50为 1.3 μM。
S8974	GSK2795039 GSK2795039 是 NADPH oxidase 2 (NOX2) 的抑制剂，对于NOX2介导的HRP/Amplex Red的激活的pIC50值为6.57。GSK2795039 可抑制活性氧reactive oxygen species (ROS)的产生，NADPH的消耗并减少细胞凋亡。
S8978	Mitoquinone (MitoQ10) mesylate Mitoquinone mesylate (MitoQ, MitoQ10, Mitoubiquinone) 是一种基于TPP的线粒体mitochondria靶向抗氧化剂，可阻断H₂O₂诱导的细胞内 ROS 反应并防止氧化损伤。该产品呈胶状。	J Exp Clin Cancer Res,2022, 41(1):83 Aging Cell,2022, 21(3):e13574 Drug Dev Res,2022, 10.1002/ddr.21911
S9107	Glycitein Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.
S7171	Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) 是一种有效的双NADPH oxidase NOX1/NOX4抑制剂，Ki分别为110 nM和140 nM。GKT137831 处理可抑制 reactive oxygen species (ROS) 的产生。GKT137831 可一定程度上抑制铁死亡。	Cell Chem Biol,2022, S2451-9456(22)00127-1 Antioxidants (Basel),2022, 11(3)513 Food Chem Toxicol,2022, 163:112966	(C) Indicated macrophages were treated with LPS (100 ng/mL) in the absence or presence of GKT137831 (1 μmol/L) for 24 h. PKM2 mRNA and lactate levels were assayed (n = 3, *, p < 0.05 versus LPS group).
S3578	Pyrroloquinoline quinone Pyrroloquinoline quinone (PQQ, Methoxatin) 是一种天然的抗氧化剂，具有抗氧化和抗衰老的作用。Pyrroloquinoline quinone 可预防雌激素缺乏引起的骨质疏松症。
S3205	Perillaldehyde Perillaldehyde (Perilladehyde, Perillal, PAE, PA) 是紫苏 Perilla frutescens（一种传统的抗氧化剂）的主要成分，可抑制BaP诱导的 AHR 的活化和 ROS 的产生，抑制 BaP/AHR 介导的 CCL2 chemokine 的释放，并激活 NRF2/HO1 抗氧化剂途径。
S2369	Troxerutin Troxerutin 是一种黄酮醇类，是一种黄酮类化合物。	Food Funct,2019, 10(8):5059-5069
S7873	Disodium (R)-2-Hydroxyglutarate Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium)是一种竞争性α-ketoglutarate-dependent dioxygenases抑制剂，其 K_i值为10.87 ± 1.85 mM。	Cell Mol Immunol,2022, 10.1038/s41423-022-00842-9 Mol Ther,2022, S1525-0016(22)00007-7 Cell Metab,2021, 33(1):110-127.e5

目录号	产品描述	文献引用	实验数据
S1046	Vandetanib (ZD6474) Vandetanib (ZD6474) 是一种有效的 VEGFR2 抑制剂，在无细胞试验中IC50为40 nM。同时，也抑制VEGFR3和EGFR，IC50分别为110 nM 和500 nM。对PDGFRβ, Flt-1, Tie-2 和FGFR1作用效果不大，IC50为 1.1-3.6 μM, 对MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt 和 IGF-1R几乎没有作用效果，IC50>10 μM。Vandetanib (ZD6474) 可增加凋亡并通过提高 reactive oxygen species (ROS) 的水平来诱导自噬。	Cancer Res, 2022, canres.1397.2021 Hum Cell, 2022, 10.1007/s13577-022-00671-y Cell Rep Med, 2022, 3(1):100492	Vandetanib increases membrane localization of endothelial NO synthase (eNOS). MS1 endothelial cells (ECs) were incubated with 1 μmol/L of vandetanib or matched vehicle (dimethyl sulfoxide [DMSO]). Western blotting analysis showed that vandetanib increases membrane localization of eNOS compared with control (*P<0.04; n=4 per group, studies done in triplicate). These findings show that vandetanib increased the membrane localization of eNOS compared with control.
S2843	BI-D1870 BI-D1870是一种ATP-竞争性S6 ribosome抑制剂，在无细胞试验中作用于RSK1/2/3/K4，IC50分别为31 nM/24 nM/18 nM/15 nM，作用于RSK比作用于MST2，GSK-3β，MARK3，CK1和Aurora B选择性高10到100倍。BI-D1870 显示除了抗癌的属性包括活性氧的生成、提高内质网应激反应和诱导自噬。	Cancer Sci, 2022, 113(1):132-144 EMBO J, 2021, 40(7):e106106 Cell Rep, 2021, 37(12):110137	Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.
S5452	Sanguinarine chloride Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor.	Front Pharmacol, 2021, 12:638215
S3238	Resibufogenin Resibufogenin (Bufogenin, Recibufogenin) 是huachansu华蟾素中具有抗癌作用的成分，通过上调 receptor-interacting protein kinase 3 (RIP3) 和磷酸化 mixed lineage kinase domain-like protein 的Ser358位点来触发坏死病。Resibufogenin 可通过诱导 reactive oxygen species (ROS) 积累发挥细胞毒性作用。Resibufogenin 可诱导凋亡和 caspase-3 和 caspase-8 活性。Resibufogenin 增加 Bax/Bcl-2 表达，并抑制 cyclin D1、cyclin E、PI3K、p-AKT、p-GSK3β 和 β-catenin 的蛋白表达。
S7309	BAY 87-2243 BAY 87-2243 是一种有效的选择性hypoxia-inducible factor-1 (HIF-1)抑制剂。BAY 87-2243 可抑制 mitochondrial complex I 的活性，从而触发依赖线粒体的ROS升高，导致细胞坏死和铁死亡ferroptosis。BAY 87-2243 具有抗肿瘤活性。Phase 1。	J Immunother Cancer, 2022, 10(3)e004414 Theranostics, 2021, 11(1):209-221 Cancer Lett, 2021, 529:19-36	Cells were plated at low density, treated with the indicated compounds and scored for resistance. Abbreviations: osimertinib (Osi), phenformin (Phen), metformin (Met), buformin (Buf), BAY 87-2243 (BAY), oligomycin (Oligo).
S0056	(E/Z)-BCI (E/Z)-BCI (BCI, NSC 150117) 是一种 dual specific phosphatase 1/6 (DUSP1/DUSP6) 和 mitogen-activated protein kinase 的抑制剂，对细胞中DUSP6和DUSP1的EC50值分别为13.3 μM和8.0 μM。(E)-BCI 在H1299肺癌细胞中通过产生 reactive oxygen species (ROS) 和激活内在的线粒体途径来诱导凋亡。
S0770	Camalexin Camalexin, a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae), can induce reactive oxygen species (ROS) production. Camalexin has antibacterial, antifungal, antiproliferative and anticancer activities.
S5263	Pyrroloquinoline Quinone Disodium Salt Pyrroloquinoline quinone (methoxatin disodium salt), an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions.
S6871	Sodium oxamate Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid)是一种 lactate dehydrogenase (LDH) 的抑制剂，可特异性地抑制LDH‑A。Sodium oxamate (SO) 通过下调 CDK1/cyclin B1 途径诱导G2/M细胞周期停滞，并通过增加线粒体内 ROS 的生成来促进凋亡。	Aging (Albany NY), 2021, 13(24):25920-25930 Int J Biol Sci, 2021, 17(11):2756-2769
S2271	Berberine chloride (NSC 646666) Berberine chloride (NSC 646666, Natural Yellow 18)是异喹啉类生物碱的季铵盐。Berberine chloride 可激活 caspase 3 和 caspase 8，分裂 poly ADP-ribose polymerase (PARP) 和释放 cytochrome c。Berberine chloride 可降低 c-IAP1，Bcl-2 和 Bcl-XL 的表达。Berberine chloride 可通过 JNK 和 p38 MAPK 的持续磷酸化以及产生 ROS 来诱导凋亡。Berberine chloride 是一个 topoisomerase I 和 II 的双效抑制剂。Berberine chloride 也是一个潜在的自噬调节剂。	Front Pharmacol, 2021, 12:632201 Molecules, 2021, 26(5)1210 Biology (Basel), 2021, 10(3)250
S8615	Sodium dichloroacetate (DCA) Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA)是 pyruvate dehydrogenase kinase (PDK) 的特异性抑制剂，对PDK2和PDK4的IC50值分别为183和80 μM；可抑制 Na⁺-K⁺-2Cl^- cotransporter 和线粒体钾离子通道轴。Sodium dichloroacetate 可增加活性氧的生成，引起癌细胞凋亡，并抑制肿瘤生长。	Nat Commun, 2022, 13(1):1417 Mol Oncol, 2022, 16(1):219-249 J Exp Clin Cancer Res, 2021, 40(1):87
S3357	Elaidic acid Elaidic acid 是一种主要的反式脂肪酸，可抑制细胞活力，并通过增强氧化应激 oxidative stress 来促进细胞的凋亡。Elaidic acid 可用作药物溶剂。
S3607	Sarsasapogenin Sarsasapogenin (SAR, Parigenin)是一种甾体皂甙元，能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活，在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。
S9611	ABTL-0812 ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) 可在肺鳞癌细胞系中通过诱导TRIB3的过表达和激活自噬来抑制 Akt/mTOR 轴。ABTL0812 还可诱导 AMPK 激活和 ROS 积累。
S2348	Rotenone (Barbasco) Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) 是一种植物杀虫剂，是线粒体电子传递mitochondrial electron transport的抑制剂。Rotenone 可抑制 NADH/DB oxidoreductase 和 NADH oxidase，对应的IC50值分别为28.8 nM和5.1 nM。Rotenone 可通过增强线粒体活性氧的产生来诱导凋亡。	Sci Signal, 2022, 15(721):eabi9983 Food Funct, 2022, 10.1039/d1fo03909a Nature, 2021, 10.1038/s41586-021-04049-2
S5584	Citronellol Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells.
S4425	Rifamycin S Rifamycin S 是一种quinone和抗 Gram-positive bacteria(包括MRSA) 的抗生素，是一种用于治疗肺结核和麻风病的临床药物。Rifamycin S 可产生 reactive oxygen species (ROS)，并抑制微粒体脂质过氧化 microsomal lipid peroxidation。
S8661	CA3 (CIL56) CA3 (CIL56) 对YAP1/Tead转录活性具有有效的抑制作用，主要靶向高表达YAP1、具有癌症干细胞属性的、难治疗的食管腺癌细胞。CA3(CIL56)可诱导铁死亡和铁依赖的活性氧自由基。	Cell Rep, 2022, 38(7):110390 Sci Rep, 2022, 12(1):45 Cancers (Basel), 2021, 13(21)5474

目录号	产品描述	文献引用	实验数据
S3301	Cynarin Cynarin (Cynarine) 是一种来自artichoke洋蓟的植物化学成分，具有多种药理特性，包括自由基清除、抗氧化剂、抗组氨酸和抗病毒活性。Cynarin 可阻断T细胞受体的 CD28 和抗原呈递细胞的 CD80 之间的相互作用。Cynarin 可触发 Nrf2 的核易位，恢复 glutathione (GSH) 和 reactive oxygen species (ROS) 的平衡，并抑制线粒体去极化。
S5804	N-Acetylcysteine amide N-acetylcysteine amide是一种能穿透细胞膜的抗氧化剂，具有消炎活性，能够调节NF-κB的激活、HIF-1α和ROS。	Nat Commun, 2021, 12(1):647 Int J Biochem Cell Biol, 2020, 121:105703 Pancreatology, 2019, 19(2):258-265
S2399	Dihydromyricetin Dihydromyricetin (Ampelopsin, Ampeloptin)是具有良好性能的天然抗氧化剂。	Molecules, 2021, 26(5)1210 Cell Signal, 2020, 65:109431 J Med Virol, 2019, 91(8):1440-1447	ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation.
S4263	Efaproxiral Sodium Efaproxiral Sodium是一种人工合成的血红素异构修饰剂，用于乳腺癌脑转移瘤的治疗。
S4419	Ensulizole Ensulizole (PBSA) 是一种水溶性防晒成分，一种磺化的UV吸收剂，其特征是可强烈吸收UVB和部分吸收UVA。Ensulizole 可以通过紫外线或日光照射下 reactive oxygen species (ROS) 的生成来破坏DNA。

目录号	产品描述	文献引用	实验数据
S2605	Idebenone Idebenone (CV-2619) 是一种辅酶Q10（CoQ10）的合成类似物，是一种大脑兴奋剂。	Cell Mol Gastroenterol Hepatol, 2021, S2352-345X(21)00196-X
S2062	Tiopronin Tiopronin是美国食品和药物管理局（FDA）批准的用于治疗治疗胱氨酸尿症的药物，通过控制胱氨酸沉淀和排泄速率。
S3222	Raspberry ketone glucoside Raspberry ketone glucoside (RKG) 是来源于树莓果实的天然产物，是一种抗氧化剂antioxidant，对黑色素 melanin 的合成具有抑制作用。
S4580	Hydroquinone Hydroquinone (Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ)是黑色素合成抑制剂。Hydroquinone的生理效应通过其褪色活性发挥。它还具有抗氧化特性，在多个器官中，尤其是肾脏中产生毒性作用。	Theranostics, 2022, 12(5):2063-2079 Neurotox Res, 2020, 2
S3632	Trichloroisocyanuric acid TrichloroisTrichloroisocyanuric acid (TCCA)是一种安全有效的试剂，作用于氯化作用和氧化反应。
S4970	Nerol Nerol (Cis-Geraniol, Neryl alcohol)是存在于多种香精油如柠檬草和槐花中的单萜化合物。
S5314	HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone) HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone), which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent.
S3838	Carnosic acid Carnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.	Am J Cancer Res, 2020, 1;10(5):1442-1454 J Reprod Dev, 2020, 10.1262/jrd.2020-086
S3840	Baohuoside I Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.
S9021	(20R)Ginsenoside Rg3 (20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.	Bioorg Chem, 2021, 111:104844 J Agric Food Chem, 2021, 69(21):6073-6086 Environ Toxicol, 2020, 10.1002/tox.22899
S9034	Isochlorogenic acid C Isochlorogenic acid C (3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid), which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.
S2332	Neohesperidin Neohesperidin (NSC 31048) 是一种抗氧化剂，在1,1-diphenyl-2-picryldydrazyl（DPPH）自由基清除测定中，IC50为22.31 μg/ml。	Curr Opin Colloid Interface Sci, 2021, 101461 Eur J Pharmacol, 2019, 864:172712 J Med Virol, 2019, 91(8):1440-1447
S3885	Pyrogallol Pyrogallol (1,2,3-trihydroxybenzene), an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.	Parasit Vectors, 2020, 13(1):449
S4511	6-Benzylaminopurine 6-Benzylaminopurine是第一代合成的细胞分裂素，可调节植物的抗氧化系统的活性。它对植物的生长和发育有一定促进作用。
S7551	Piperlongumine Piperlongumine (PPLGM, Piplartine)，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。	Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Nat Commun, 2022, 13(1):107 SLAS Discov, 2021, 24725552211020678	a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. P < 0.05; P < 0.01; **P < 0.001.
S9687	H2DCFDA H2DCFDA (DCFH-DA, 2',7'-Dichlorodihydrofluorescein diacetate) 是一种可渗透细胞的探针，可用于检测细胞内 reactive oxygen species (ROS) 的产生。
S7867	Oleuropein Oleuropein 是一种从橄榄叶中分离出的抗氧化多酚。Oleuropein 具有抗氧化、抗炎和抗动脉粥样硬化的作用，并在体外抑制脂肪细胞的分化。Oleuropein 抑制 PPARγ 活性。Oleuropein 通过直接抑制PPARγ转录活性发挥抗脂肪形成作用。Oleuropein 还可抑制aromatase。Oleuropein 可诱导凋亡。Phase 2。	J Med Virol, 2019, 91(8):1440-1447
S2363	Tangeretin Tangeretin (Tangeritin)是一种柑橘类黄酮。	Evid Based Complement Alternat Med, 2022, 2022:6422500 Int J Mol Sci, 2020, 21(14):5025 Cancer Manag Res, 2019, 11:5231-5242
S4722	(+)-Catechin (+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) 是抗氧化类黄酮，主要以(+)-catechin和(-)-epicatechin的形式存在于木本植物中。	J Steroid Biochem Mol Biol, 2021, 211:105906
S4723	(-)Epicatechin (−)Epicatechin (L-Epicatechin, (-)-Epicatechol)是一种类黄酮，在可可、绿茶、红酒中常见。具有强的抗氧化、胰岛素类似作用，能改善心脏健康。	J Steroid Biochem Mol Biol, 2021, 211:105906 G3 (Bethesda), 2020, 4;10(5):1585-1597

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