ROS

抑制剂选择性比较

ROS产品

目录号 产品描述 文献引用 实验数据
S1547

Febuxostat

Febuxostat 是一种非嘌呤,选择性黄嘌呤氧化酶抑制剂,IC50为114-210 nM。

S1623

Acetylcysteine(N-acetylcysteine)

Acetylcysteine(N-acetyl-l-cysteine)是ROS抑制剂,拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂,主要用作祛痰剂,可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用

S1630

Allopurinol

Allopurinol 是一种黄嘌呤氧化酶抑制剂,IC50为7.82±0.12 μM。

S3616

Asiaticoside

Asiaticoside是Centella asiatica(积雪草)中的主要活性成分,通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。

S3631

(S)-Methylisothiourea sulfate

(S)-Methylisothiourea sulfate是iNOS的抑制剂。

S4017

Allylthiourea

Allylthiourea是一种代谢抑制剂,选择性抑制ammonia oxidation(氨氧化)

S4853

Ecabet sodium

Ecabet sodium is a widely employed mucoprotective agent for the treatment of gastric ulcers.

S3816

Dehydroevodiamine

Dehydroevodiamine, a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.

S3973

L-SelenoMethionine

L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.

S4603

Gallic acid

Gallic acid是一种在多种食物和草药中发现的有机酸,是有效的抗氧化剂。

S1631

Allopurinol Sodium

Allopurinol Sodium 是一种黄嘌呤氧化酶抑制剂,IC50为7.82±0.12 μM。

S9107

Glycitein

Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.

S2369

Troxerutin

Troxerutin 是一种黄酮醇类,是一种黄酮类化合物。

S7873

Disodium (R)-2-Hydroxyglutarate

Disodium (R)-2-Hydroxyglutarate是一种竞争性α-ketoglutarate-dependent dioxygenases抑制剂,其 Ki值为10.87 ± 1.85 mM。

S5452

Sanguinarine chloride

Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor.

S5263

Pyrroloquinoline Quinone Disodium Salt

Pyrroloquinoline quinone, an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions.

S3607

Sarsasapogenin

Sarsasapogenin (SAR)是一种甾体皂甙元,能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κBMAPK的激活,在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。

S8661

CA3(CIL56)

CA3(CIL56) 对YAP1/Tead转录活性具有有效的抑制作用,主要靶向高表达YAP1、具有癌症干细胞属性的、难治疗的食管腺癌细胞。CA3(CIL56)可诱导铁死亡和铁依赖的活性氧自由基。

S5804

N-Acetylcysteine amide

N-acetylcysteine amide是一种能穿透细胞膜的抗氧化剂,具有消炎活性,能够调节NF-κB的激活、HIF-1α和ROS。

S2399

Dihydromyricetin

Dihydromyricetin 是具有良好性能的天然抗氧化剂。

S4263

Efaproxiral Sodium

Efaproxiral Sodium是一种人工合成的血红素异构修饰剂,用于乳腺癌脑转移瘤的治疗。

S2605

Idebenone

Idebenone是一种辅酶Q10(CoQ10)的合成类似物,是一种大脑兴奋剂。

S2062

Tiopronin

Tiopronin是美国食品和药物管理局(FDA)批准的用于治疗治疗胱氨酸尿症的药物,通过控制胱氨酸沉淀和排泄速率。

S4580

Hydroquinone

Hydroquinone是黑色素合成抑制剂。Hydroquinone的生理效应通过其褪色活性发挥。它还具有抗氧化特性,在多个器官中,尤其是肾脏中产生毒性作用。

S4970

Nerol

Nerol是存在于多种香精油如柠檬草和槐花中的单萜化合物。

S5314

HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)

HTHQ, which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent.

S3838

Carnosic acid

Carnosic acid is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.

S3840

Baohuoside I

Baohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.

S9021

(20R)Ginsenoside Rg3

(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.

S9034

Isochlorogenic acid C

Isochlorogenic acid C, which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.

S2332

Neohesperidin

Neohesperidin 是一种抗氧化剂,在1,1-diphenyl-2-picryldydrazyl(DPPH)自由基清除测定中,IC50为22.31 μg/ml。

S3885

Pyrogallol

Pyrogallol, an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.

S4511

6-Benzylaminopurine

6-Benzylaminopurine是第一代合成的细胞分裂素,可调节植物的抗氧化系统的活性。它对植物的生长和发育有一定促进作用。

S7551

Piperlongumine

Piperlongumine,存在于胡椒科植物荜茇中的一种天然生物碱,能够增加reactive oxygen species (ROS)水平,并选择性杀死癌细胞。它还是TrxR1的直接抑制剂,对胃癌具有抑制活性;一种新型的CRM1抑制剂;在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR

S7867

Oleuropein

Oleuropein 是一种从橄榄叶中分离出的抗氧化多酚。Oleuropein 具有抗氧化、抗炎和抗动脉粥样硬化的作用,并在体外抑制脂肪细胞的分化。Oleuropein 抑制 PPARγ 活性。Oleuropein 通过直接抑制PPARγ转录活性发挥抗脂肪形成作用。Oleuropein 还可抑制aromatase。Oleuropein 可诱导凋亡。Phase 2。

S2363

Tangeretin

Tangeretin 是一种柑橘类黄酮。

S4722

(+)-Catechin

Cianidanol是抗氧化类黄酮,主要以(+)-catechin和(-)-epicatechin的形式存在于木本植物中。

S4723

(-)Epicatechin

(−)Epicatechin是一种类黄酮,在可可、绿茶、红酒中常见。具有强的抗氧化、胰岛素类似作用,能改善心脏健康。

目录号 产品描述 文献引用 实验数据
S1547

Febuxostat

Febuxostat 是一种非嘌呤,选择性黄嘌呤氧化酶抑制剂,IC50为114-210 nM。

S1623

Acetylcysteine(N-acetylcysteine)

Acetylcysteine(N-acetyl-l-cysteine)是ROS抑制剂,拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂,主要用作祛痰剂,可通过维持或恢复肝脏中谷胱甘肽的浓度来处理扑热息痛(对乙酰氨基酚过量)。Acetylcysteine(N-acetyl-l-cysteine) 通过抑制IκB kinases抑制TNF诱导的NF-κB活化。Acetylcysteine(N-acetyl-l-cysteine) 通过线粒体依赖性途径诱导凋亡并抑制铁死亡和病毒复制。现配现用

S1630

Allopurinol

Allopurinol 是一种黄嘌呤氧化酶抑制剂,IC50为7.82±0.12 μM。

S3616

Asiaticoside

Asiaticoside是Centella asiatica(积雪草)中的主要活性成分,通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。

S3631

(S)-Methylisothiourea sulfate

(S)-Methylisothiourea sulfate是iNOS的抑制剂。

S4017

Allylthiourea

Allylthiourea是一种代谢抑制剂,选择性抑制ammonia oxidation(氨氧化)

S4853

Ecabet sodium

Ecabet sodium is a widely employed mucoprotective agent for the treatment of gastric ulcers.

S3816

Dehydroevodiamine

Dehydroevodiamine, a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.

S3973

L-SelenoMethionine

L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.

S4603

Gallic acid

Gallic acid是一种在多种食物和草药中发现的有机酸,是有效的抗氧化剂。

S1631

Allopurinol Sodium

Allopurinol Sodium 是一种黄嘌呤氧化酶抑制剂,IC50为7.82±0.12 μM。

S9107

Glycitein

Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.

S2369

Troxerutin

Troxerutin 是一种黄酮醇类,是一种黄酮类化合物。

S7873

Disodium (R)-2-Hydroxyglutarate

Disodium (R)-2-Hydroxyglutarate是一种竞争性α-ketoglutarate-dependent dioxygenases抑制剂,其 Ki值为10.87 ± 1.85 mM。

目录号 产品描述 文献引用 实验数据
S5452

Sanguinarine chloride

Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor.

S5263

Pyrroloquinoline Quinone Disodium Salt

Pyrroloquinoline quinone, an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions.

S3607

Sarsasapogenin

Sarsasapogenin (SAR)是一种甾体皂甙元,能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κBMAPK的激活,在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。

S8661

CA3(CIL56)

CA3(CIL56) 对YAP1/Tead转录活性具有有效的抑制作用,主要靶向高表达YAP1、具有癌症干细胞属性的、难治疗的食管腺癌细胞。CA3(CIL56)可诱导铁死亡和铁依赖的活性氧自由基。

目录号 产品描述 文献引用 实验数据
S5804

N-Acetylcysteine amide

N-acetylcysteine amide是一种能穿透细胞膜的抗氧化剂,具有消炎活性,能够调节NF-κB的激活、HIF-1α和ROS。

S2399

Dihydromyricetin

Dihydromyricetin 是具有良好性能的天然抗氧化剂。

S4263

Efaproxiral Sodium

Efaproxiral Sodium是一种人工合成的血红素异构修饰剂,用于乳腺癌脑转移瘤的治疗。

目录号 产品描述 文献引用 实验数据
S2605

Idebenone

Idebenone是一种辅酶Q10(CoQ10)的合成类似物,是一种大脑兴奋剂。

S2062

Tiopronin

Tiopronin是美国食品和药物管理局(FDA)批准的用于治疗治疗胱氨酸尿症的药物,通过控制胱氨酸沉淀和排泄速率。

S4580

Hydroquinone

Hydroquinone是黑色素合成抑制剂。Hydroquinone的生理效应通过其褪色活性发挥。它还具有抗氧化特性,在多个器官中,尤其是肾脏中产生毒性作用。

S4970

Nerol

Nerol是存在于多种香精油如柠檬草和槐花中的单萜化合物。

S5314

HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)

HTHQ, which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent.

S3838

Carnosic acid

Carnosic acid is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.

S3840

Baohuoside I

Baohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.

S9021

(20R)Ginsenoside Rg3

(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.

S9034

Isochlorogenic acid C

Isochlorogenic acid C, which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.

S2332

Neohesperidin

Neohesperidin 是一种抗氧化剂,在1,1-diphenyl-2-picryldydrazyl(DPPH)自由基清除测定中,IC50为22.31 μg/ml。

S3885

Pyrogallol

Pyrogallol, an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.

S4511

6-Benzylaminopurine

6-Benzylaminopurine是第一代合成的细胞分裂素,可调节植物的抗氧化系统的活性。它对植物的生长和发育有一定促进作用。

S7551

Piperlongumine

Piperlongumine,存在于胡椒科植物荜茇中的一种天然生物碱,能够增加reactive oxygen species (ROS)水平,并选择性杀死癌细胞。它还是TrxR1的直接抑制剂,对胃癌具有抑制活性;一种新型的CRM1抑制剂;在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR

S7867

Oleuropein

Oleuropein 是一种从橄榄叶中分离出的抗氧化多酚。Oleuropein 具有抗氧化、抗炎和抗动脉粥样硬化的作用,并在体外抑制脂肪细胞的分化。Oleuropein 抑制 PPARγ 活性。Oleuropein 通过直接抑制PPARγ转录活性发挥抗脂肪形成作用。Oleuropein 还可抑制aromatase。Oleuropein 可诱导凋亡。Phase 2。

S2363

Tangeretin

Tangeretin 是一种柑橘类黄酮。

S4722

(+)-Catechin

Cianidanol是抗氧化类黄酮,主要以(+)-catechin和(-)-epicatechin的形式存在于木本植物中。

S4723

(-)Epicatechin

(−)Epicatechin是一种类黄酮,在可可、绿茶、红酒中常见。具有强的抗氧化、胰岛素类似作用,能改善心脏健康。