ROS
抑制剂选择性比较
ROS产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1068 |
Crizotinib (PF-02341066)Crizotinib (PF-02341066) 克唑替尼是一种有效的c-Met和ALK抑制剂，在细胞试验中IC50分别为11 nM 和 24 nM。它同时也是有效的ROS1抑制剂，其Ki值小于0.025 nM。 |
(c) Western blot analyses of p-Akt (Ser473) and p-S6RP (Ser235 and Ser236) in two RCT-E565 transplanted tumors treated with vehicle or PF02341066. Samples were isolated 4 h after the last dose from mice treated with PF02341066 for 3 d. (d) Responses of RCT-E565 transplanted tumors in athymic mice to PF02341066 or vehicle. Data are means ±s.e.m. (each group, n = 6). *P < 0.005, **P < 0.001 (Student,s t test). |
|
| S1547 |
FebuxostatFebuxostat 是一种非嘌呤，选择性黄嘌呤氧化酶抑制剂，IC50为114-210 nM。 |
NOX activity was measured as lucigenin-dependent chemiluminescence of superoxide. Incubation with febuxostat increased superoxide generation in nonactivated macrophages, but did not significantly influence superoxide formation in LPS-activated macrophages. Simultaneous treatment with febuxostat abolished the effect of nitrite during activation with LPS. Data are means±SEM (n=10-12). *, p<0.05. LPS, lipopolysaccharide (10 ng/ml); NO2, sodium nitrite (10 μM); febuxostat, xanthine oxidase inhibitor (30 nM). |
|
| S1623 |
Acetylcysteine(N-acetylcysteine)Acetylcysteine(N-acetyl-l-cysteine)是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可处理扑热息痛(对乙酰氨基酚)过量。 |
(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
|
|
| S1630 |
AllopurinolAllopurinol 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。 |
||
| S3616 |
AsiaticosideAsiaticoside是Centella asiatica（积雪草）中的主要活性成分，通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。 |
||
| S3631 |
(S)-Methylisothiourea sulfate(S)-Methylisothiourea sulfate是iNOS的抑制剂。 |
||
| S3973 |
L-SelenoMethionineL-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense. |
||
| S4603 |
Gallic acidGallic acid是一种在多种食物和草药中发现的有机酸，是有效的抗氧化剂。 |
||
| S1631 |
Allopurinol SodiumAllopurinol Sodium 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。 |
||
| S9107 |
GlyciteinGlycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities. |
||
| S5263 |
Pyrroloquinoline Quinone Disodium SaltPyrroloquinoline quinone, an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions. |
||
| S3607 |
SarsasapogeninSarsasapogenin (SAR)是一种甾体皂甙元，能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活，在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。 |
||
| S2399 |
DihydromyricetinDihydromyricetin 是具有良好性能的天然抗氧化剂。 |
ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation. |
|
| S2605 |
IdebenoneIdebenone是一种辅酶Q10（CoQ10）的合成类似物，是一种大脑兴奋剂。 |
||
| S2062 |
TioproninTiopronin是美国食品和药物管理局（FDA）批准的用于治疗治疗胱氨酸尿症的药物，通过控制胱氨酸沉淀和排泄速率。 |
||
| S4580 |
HydroquinoneHydroquinone是黑色素合成抑制剂。Hydroquinone的生理效应通过其褪色活性发挥。它还具有抗氧化特性，在多个器官中，尤其是肾脏中产生毒性作用。 |
||
| S3838 |
Carnosic acidCarnosic acid is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries. |
||
| S3840 |
Baohuoside IBaohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway. |
||
| s9021 |
(20R)Ginsenoside Rg3(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite. |
||
| s9034 |
Isochlorogenic acid CIsochlorogenic acid C, which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71. |
||
| S2332 |
NeohesperidinNeohesperidin 是一种抗氧化剂，在1,1-diphenyl-2-picryldydrazyl（DPPH）自由基清除测定中，IC50为22.31 μg/ml。 |
||
| S3885 |
PyrogallolPyrogallol, an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer. |
||
| S4511 |
6-Benzylaminopurine6-Benzylaminopurine是第一代合成的细胞分裂素，可调节植物的抗氧化系统的活性。它对植物的生长和发育有一定促进作用。 |
||
| S7551 |
PiperlonguminePiperlongumine，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。 |
a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. *P < 0.05; **P < 0.01; ***P < 0.001.
|
|
| S7867 |
OleuropeinOleuropein是一种从橄榄叶中分离出的抗氧化多酚。Phase 2。 |
||
| S2363 |
TangeretinTangeretin 是一种柑橘类黄酮。 |
||
| S4722 |
(+)-CatechinCianidanol是抗氧化类黄酮，主要以(+)-catechin和(-)-epicatechin的形式存在于木本植物中。 |
||
| S4723 |
(-)Epicatechin(−)Epicatechin是一种类黄酮，在可可、绿茶、红酒中常见。具有强的抗氧化、胰岛素类似作用，能改善心脏健康。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1068 |
Crizotinib (PF-02341066)Crizotinib (PF-02341066) 克唑替尼是一种有效的c-Met和ALK抑制剂，在细胞试验中IC50分别为11 nM 和 24 nM。它同时也是有效的ROS1抑制剂，其Ki值小于0.025 nM。 |
(c) Western blot analyses of p-Akt (Ser473) and p-S6RP (Ser235 and Ser236) in two RCT-E565 transplanted tumors treated with vehicle or PF02341066. Samples were isolated 4 h after the last dose from mice treated with PF02341066 for 3 d. (d) Responses of RCT-E565 transplanted tumors in athymic mice to PF02341066 or vehicle. Data are means ±s.e.m. (each group, n = 6). *P < 0.005, **P < 0.001 (Student,s t test). |
|
| S1547 |
FebuxostatFebuxostat 是一种非嘌呤，选择性黄嘌呤氧化酶抑制剂，IC50为114-210 nM。 |
NOX activity was measured as lucigenin-dependent chemiluminescence of superoxide. Incubation with febuxostat increased superoxide generation in nonactivated macrophages, but did not significantly influence superoxide formation in LPS-activated macrophages. Simultaneous treatment with febuxostat abolished the effect of nitrite during activation with LPS. Data are means±SEM (n=10-12). *, p<0.05. LPS, lipopolysaccharide (10 ng/ml); NO2, sodium nitrite (10 μM); febuxostat, xanthine oxidase inhibitor (30 nM). |
|
| S1623 |
Acetylcysteine(N-acetylcysteine)Acetylcysteine(N-acetyl-l-cysteine)是ROS抑制剂，拮抗多种蛋白酶体抑制剂的活性。它还是肿瘤坏死因子TNF的抑制剂，主要用作祛痰剂，可处理扑热息痛(对乙酰氨基酚)过量。 |
(C) Double immunolabeling showed CK-labeled cells (green) co-expressed with 40, 6-diamidino-2-phenylindole (DAPI) (blue), scale bars are 50 μm.
|
|
| S1630 |
AllopurinolAllopurinol 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。 |
||
| S3616 |
AsiaticosideAsiaticoside是Centella asiatica（积雪草）中的主要活性成分，通过抑制紫外线A诱导的ROS生成、阻止紫外线A依赖性的光老化。它还能通过MITF减少DNA结合。 |
||
| S3631 |
(S)-Methylisothiourea sulfate(S)-Methylisothiourea sulfate是iNOS的抑制剂。 |
||
| S3973 |
L-SelenoMethionineL-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense. |
||
| S4603 |
Gallic acidGallic acid是一种在多种食物和草药中发现的有机酸，是有效的抗氧化剂。 |
||
| S1631 |
Allopurinol SodiumAllopurinol Sodium 是一种黄嘌呤氧化酶抑制剂，IC50为7.82±0.12 μM。 |
||
| S9107 |
GlyciteinGlycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities. |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S5263 |
Pyrroloquinoline Quinone Disodium SaltPyrroloquinoline quinone, an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic substrates to molecular oxygen (O2), constructing quinoprotein model reactions. |
||
| S3607 |
SarsasapogeninSarsasapogenin (SAR)是一种甾体皂甙元，能够诱发ROS的产生并激活unfolded protein response (UPR)信号通路。SAR能够有效地抑制NF-κB和MAPK的激活，在LPS刺激的巨噬细胞中抑制IRAK1、TAK1和IκBα的磷酸化。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S2399 |
DihydromyricetinDihydromyricetin 是具有良好性能的天然抗氧化剂。 |
ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation. |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S2605 |
IdebenoneIdebenone是一种辅酶Q10（CoQ10）的合成类似物，是一种大脑兴奋剂。 |
||
| S2062 |
TioproninTiopronin是美国食品和药物管理局（FDA）批准的用于治疗治疗胱氨酸尿症的药物，通过控制胱氨酸沉淀和排泄速率。 |
||
| S4580 |
HydroquinoneHydroquinone是黑色素合成抑制剂。Hydroquinone的生理效应通过其褪色活性发挥。它还具有抗氧化特性，在多个器官中，尤其是肾脏中产生毒性作用。 |
||
| S3838 |
Carnosic acidCarnosic acid is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries. |
||
| S3840 |
Baohuoside IBaohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway. |
||
| s9021 |
(20R)Ginsenoside Rg3(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite. |
||
| s9034 |
Isochlorogenic acid CIsochlorogenic acid C, which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71. |
||
| S2332 |
NeohesperidinNeohesperidin 是一种抗氧化剂，在1,1-diphenyl-2-picryldydrazyl（DPPH）自由基清除测定中，IC50为22.31 μg/ml。 |
||
| S3885 |
PyrogallolPyrogallol, an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer. |
||
| S4511 |
6-Benzylaminopurine6-Benzylaminopurine是第一代合成的细胞分裂素，可调节植物的抗氧化系统的活性。它对植物的生长和发育有一定促进作用。 |
||
| S7551 |
PiperlonguminePiperlongumine，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。 |
a. Cell growth of ARID1A-wildtype RMG1 cells transfected with ARID1A and non-target siRNA for 24 h and treated with piperlongumine for 72 h. b. Apoptosis of RMG1 cells after transfection and treatment as described in a as measured using annexin-V and PI staining. c. Cell growth of RMG1 cells transfected and treated with 5 μM of piperlongumine as described in a, but in the presence or absence of the antioxidant NAC. Cell growth was measured using the WST-1 assay and quantified relative to DMSO treated non-target control. *P < 0.05; **P < 0.01; ***P < 0.001.
|
|
| S7867 |
OleuropeinOleuropein是一种从橄榄叶中分离出的抗氧化多酚。Phase 2。 |
||
| S2363 |
TangeretinTangeretin 是一种柑橘类黄酮。 |
||
| S4722 |
(+)-CatechinCianidanol是抗氧化类黄酮，主要以(+)-catechin和(-)-epicatechin的形式存在于木本植物中。 |
||
| S4723 |
(-)Epicatechin(−)Epicatechin是一种类黄酮，在可可、绿茶、红酒中常见。具有强的抗氧化、胰岛素类似作用，能改善心脏健康。 |
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