Carnosic acid

For research use only. Not for use in humans.

目录号:S3838 别名: Salvin 中文名称:鼠尾草酸

Carnosic acid Chemical Structure

CAS No. 3650-09-7

Carnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.

规格 价格 库存 购买数量  
RMB 876.74 现货
RMB 2350.78 现货
有超大折扣

今日订购,明日送达,全国免运费!

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Carnosic acid发表文献2篇:

产品安全说明书

ROS抑制剂选择性比较

生物活性

产品描述 Carnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.
体外研究

Carnosic acid (CA) would inhibit the cell viability of three CRC cell lines: Caco-2, HT29 and LoVo in a dose-dependent manner, with IC50 values in the range of 24-96 μM. CA induces cell death by apoptosis in Caco-2 line after 24 h of treatment and inhibits cell adhesion and migration, possibly by reducing the activity of secreted proteases such as urokinase plasminogen activator (uPA) and metalloproteinases (MMPs). CA downregulates the expression of COX-2 in Caco-2 cells at both the mRNA and protein levels[1]. CA induces antioxidant and anti-inflammatory effects in several cell types, as observed in both in vitro and in vivo experimental models. It exhibits the ability to promote mitochondrial protection in neural cells[2]. In vitro, CA suppresses Receptor Activator for Nuclear Factor-κ B Ligand (RANKL)- and Macrophage colony-stimulating factor (M-CSF)-induced osteoclastogenesis. The osteoclastic specific markers are inhibited by CA. Signal transduction studies show that CA significantly decreases the expression of molecules contributing to ROS and increases anti-oxidants. Additionally, CA inactivates the RANKL- and M-CSF-induced p38 mitogen activated protein kinases (MAPK), inhibits NF-κB phosphorylation, causing pro-inflammatory cytokines down-regulation. CA ameliorates acute promyelocytic leukemia cells through activating nuclear transcription factor E2-related factor 2 (Nrf2), which plays an essential role in cytoprotective responses to oxidative stress[3].

体内研究 CA significantly down-regulates fasting blood glucose, glucose level in oral glucose tolerance test (OGTT) and insulin tolerance test (ITT), ameliorates CIA-induced bone loss, and reduces pro-inflammatory cytokines and reactive oxygen species (ROS) in db/db mice with arthritis induced by collagen-induced arthritis (CIA). CA could regulate ER stress to ameliorate disease progression. It can also cross the blood-brain barrier readily and exert its protective effects via its potent anti-oxidative role[3].

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:[1]
- 合并
  • Cell lines: Human colon carcinoma cell lines, Caco-2, HT29 and LoVo
  • Concentrations: 0 to 388 μM
  • Incubation Time: 24 h
  • Method: Cells (1×104) are seeded in 96-well microplates in complete medium. After 48 h, cells are washed twice with PBS and treated with RE, RA and CA (concentration range from 0 to 388 μM) in complete medium for 24 h. Cell viability is assessed.
    (Only for Reference)
动物实验:[3]
- 合并
  • Animal Models: male C57BL/KsJ-db/db (db/db) mice
  • Dosages: 30 mg/kg and 60 mg/kg
  • Administration: i.p.
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 66 mg/mL (198.53 mM)

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 332.43
化学式

C20H28O4

CAS号 3650-09-7
储存条件 粉状
溶于溶剂
别名 Salvin

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项
免费分装抑制剂
Tags: 购买Carnosic acid | Carnosic acid供应商 | 采购Carnosic acid | Carnosic acid价格 | Carnosic acid生产 | 订购Carnosic acid | Carnosic acid代理商
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID