JNK
信号通路图
研究领域
抑制剂选择性比较
JNK产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1460 |
SP600125SP600125是一种广谱JNK抑制剂，作用于JNK1，JNK2和JNK3，无细胞试验中IC50分别为40 nM，40 nM和90 nM，比作用于MKK4选择性高10倍，比作用于MKK3， MKK6， PKB，和PKCα选择性高25倍，比作用于ERK2， p38， Chk1， EGFR等选择性高100倍。 |
Western blotting analysis of total cell lysates from liver of Ulk1/2 Ctrl and LDKO mice treated or untreated with JNK inhibitor SP00125 (10 mg/kg) or APAP for 6 h.
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| S4901 |
JNK-IN-8JNK-IN-8是第一个不可逆的JNK抑制剂，作用于JNK1，JNK2和JNK3，在A375细胞系中IC50分别为4.7 nM，18.7 nM和1 nM，比作用于MNK2，Fms选择性高10倍以上，对c-Kit， Met， PDGFRβ没有抑制作用。 |
The viability of DLBCL cell lines was assessed after 72 h of treatment with the indicated concentrations of the JNK inhibitor JNK-IN-8. Mean + SEM of at least three independent experiments is shown.
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| S7508 |
JNK Inhibitor IXJNK inhibitor IX 是一种高度选择性JNK抑制剂，其作用于JNK2和JNK3的pIC50分别为6.5和6.7。 |
ICT induces JNK activation, mediating mPTP opening and CRC cell necrosis. JNK expression (p- and regular) in HT-29 or the primary CRC cells stimulated with applied ICT was tested by Western blots (a).
HT-29 cells were pre-treated with JNK inhibitors SP600125 (SP), JNK inhibitor IX (JNK-IX), and JNK-IN-8 (JNKi-8) (5 μM each) for 1 h, followed by ICT (25 μM) stimulation, MMP decrease was tested by
JC-10 dye assay (b, after 12 h), and cell necrosis was tested by LDH release assay (c, after 72 h).
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| S8490 |
Tanzisertib(CC-930)CC-930对依赖于JNK的蛋白质底物c-Jun和JNK所有亚型的磷酸化具有ATP竞争性抑制作用(Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM)，选择性抑制ERK1和p38a的IC50分别为0.48 μM和3.4 μM。 |
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| S8201 |
BI-78D3BI-78D3是一种竞争性的JNK抑制剂，IC50为280 nM，其选择性比对p38α高100倍，对mTOR和PI-3K没有活性。 |
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| S7409 |
AnisomycinAnisomycin 是一种抗生素，抑制蛋白质合成，也是一种 JNK 激活剂。 |
The co-immunofluorescence of mitochondria and lysosomes. DUSP1 alleviated the overlap of mitochondria and lysosomes. Anisomycin (Ani) is the activator of JNK, which was used to reactivate the JNK activity in DUSP1-overepxressed cells.
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| S7637 |
DTP3DTP3是一种选择性GADD45β/MKK7抑制剂，能够抑制癌症选择性NF-κB存活途径。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1460 |
SP600125SP600125是一种广谱JNK抑制剂，作用于JNK1，JNK2和JNK3，无细胞试验中IC50分别为40 nM，40 nM和90 nM，比作用于MKK4选择性高10倍，比作用于MKK3， MKK6， PKB，和PKCα选择性高25倍，比作用于ERK2， p38， Chk1， EGFR等选择性高100倍。 |
Western blotting analysis of total cell lysates from liver of Ulk1/2 Ctrl and LDKO mice treated or untreated with JNK inhibitor SP00125 (10 mg/kg) or APAP for 6 h.
|
|
| S4901 |
JNK-IN-8JNK-IN-8是第一个不可逆的JNK抑制剂，作用于JNK1，JNK2和JNK3，在A375细胞系中IC50分别为4.7 nM，18.7 nM和1 nM，比作用于MNK2，Fms选择性高10倍以上，对c-Kit， Met， PDGFRβ没有抑制作用。 |
The viability of DLBCL cell lines was assessed after 72 h of treatment with the indicated concentrations of the JNK inhibitor JNK-IN-8. Mean + SEM of at least three independent experiments is shown.
|
|
| S7508 |
JNK Inhibitor IXJNK inhibitor IX 是一种高度选择性JNK抑制剂，其作用于JNK2和JNK3的pIC50分别为6.5和6.7。 |
ICT induces JNK activation, mediating mPTP opening and CRC cell necrosis. JNK expression (p- and regular) in HT-29 or the primary CRC cells stimulated with applied ICT was tested by Western blots (a).
HT-29 cells were pre-treated with JNK inhibitors SP600125 (SP), JNK inhibitor IX (JNK-IX), and JNK-IN-8 (JNKi-8) (5 μM each) for 1 h, followed by ICT (25 μM) stimulation, MMP decrease was tested by
JC-10 dye assay (b, after 12 h), and cell necrosis was tested by LDH release assay (c, after 72 h).
|
|
| S8490 |
Tanzisertib(CC-930)CC-930对依赖于JNK的蛋白质底物c-Jun和JNK所有亚型的磷酸化具有ATP竞争性抑制作用(Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM)，选择性抑制ERK1和p38a的IC50分别为0.48 μM和3.4 μM。 |
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| S8201 |
BI-78D3BI-78D3是一种竞争性的JNK抑制剂，IC50为280 nM，其选择性比对p38α高100倍，对mTOR和PI-3K没有活性。 |
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7409 |
AnisomycinAnisomycin 是一种抗生素，抑制蛋白质合成，也是一种 JNK 激活剂。 |
2017, 8(1):e2529 2017, 10.1002/jcb.26176 2016, 68(6):2389-2394 |
The co-immunofluorescence of mitochondria and lysosomes. DUSP1 alleviated the overlap of mitochondria and lysosomes. Anisomycin (Ani) is the activator of JNK, which was used to reactivate the JNK activity in DUSP1-overepxressed cells.
|
| S7637 |
DTP3DTP3是一种选择性GADD45β/MKK7抑制剂，能够抑制癌症选择性NF-κB存活途径。 |
